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  • 1
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    Phase transitions in semidefinite relaxations [Applied Mathematics] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-04-20
    Description: Statistical inference problems arising within signal processing, data mining, and machine learning naturally give rise to hard combinatorial optimization problems. These problems become intractable when the dimensionality of the data is large, as is often the case for modern datasets. A popular idea is to construct convex relaxations of these...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations (2016)
    Oxford University Press
    Details
    Publication Date: 2016-02-16
    Description: Mutations in mitochondrial (mt) genes coding for mt-tRNAs are responsible for a range of syndromes, for which no effective treatment is available. We recently showed that the carboxy-terminal domain (Cterm) of human mt-leucyl tRNA synthetase rescues the pathologic phenotype associated either with the m.3243A〉G mutation in mt-tRNA Leu(UUR) or with mutations in the mt-tRNA Ile , both of which are aminoacylated by Class I mt-aminoacyl-tRNA synthetases (mt-aaRSs). Here we show, by using the human transmitochondrial cybrid model, that the Cterm is also able to improve the phenotype caused by the m.8344A〉G mutation in mt-tRNA Lys , aminoacylated by a Class II aaRS. Importantly, we demonstrate that the same rescuing ability is retained by two Cterm-derived short peptides, β30_31 and β32_33, which are effective towards both the m.8344A〉G and the m.3243A〉G mutations. Furthermore, we provide in vitro evidence that these peptides bind with high affinity wild-type and mutant human mt-tRNA Leu(UUR) and mt-tRNA Lys , and stabilize mutant mt-tRNA Leu(UUR) . In conclusion, we demonstrate that small Cterm-derived peptides can be effective tools to rescue cellular defects caused by mutations in a wide range of mt-tRNAs.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    Injection of auxiliary electrons for increasing the plasma density in highly charged and high intensity ion sources (2015)
    American Institute of Physics (AIP)
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    Publication Date: 2015-12-23
    Description: Different electron guns based on cold- or hot-cathode technologies have been developed since 2009 at INFN for operating within ECR plasma chambers as sources of auxiliary electrons, with the aim of boosting the source performances by means of a higher plasma lifetime and density. Their application to microwave discharge ion sources, where plasma is not confined, has required an improvement of the gun design, in order to “screen” the cathode from the plasma particles. Experimental tests carried out on a plasma reactor show a boost of the plasma density, ranging from 10% to 90% when the electron guns are used, as explained by plasma diffusion models.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 4
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    Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design (2016)
    American Chemical Society (ACS)
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    Publication Date: 2016-02-27
    Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b01946
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 5
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    Syn-convergent extension observed using the RETREAT GPS network, northern Apennines, Italy (2012)
    Wiley
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    Publication Date: 2012-04-21
    Description: We present crustal deformation results from a geodetic experiment (Retreating-Trench, Extension, and Accretion Tectonics (RETREAT)) focused on the northern Apennines orogen in Italy. The experiment centers on 33 benchmarks measured with GPS annually or more frequently between 2003 and 2007, supplemented by data from an additional older set of 6 campaign observations from stations in northern Croatia, and 187 continuous GPS stations within and around northern Italy. In an attempt to achieve the best possible estimates for rates and their uncertainties, we estimate and filter common mode signals and noise components using the continuous stations and apply these corrections to the entire data set, including the more temporally limited campaign time series. The filtered coordinate time series data are used to estimate site velocity. We also estimate spatially variable seasonal site motions for stations with sufficient data. The RMS scatter of residual time series are generally near 1 mm and 4 mm, horizontal and vertical, respectively, for continuous and most of the new campaign stations, but scatter is slightly higher for some of the older campaign data. Velocity uncertainties are below 1 mm/yr for all but one of the stations. Maximum rates of site motion within the orogen exceed 3 mm/yr (directed NE) relative to stable Eurasia. This motion is accommodated by extension within the southwestern and central portions of the orogen, and shortening across the foreland thrust belt to the northeast of the range. The data set is consistent with contemporaneous extension and shortening at nearly equal rates. The northern Apennines block moves northeast faster than the Northern Adria microplate. Convergence between the Northern Apennines block and the Northern Adria microplate is accommodated across a narrow zone that coincides with the northeastern Apennines range front. Extension occurs directly above an intact vertically dipping slab inferred by previous authors from seismic tomography. The observed crustal deformation is consistent with a buried dislocation model for crustal faulting, but associations between crustal motion and seismically imaged mantle structure may also provide new insights on mantle dynamics.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
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    Ascent of dinosaurs linked to an iridium anomaly at the Triassic-Jurassic boundary (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-23
    Description: Analysis of tetrapod footprints and skeletal material from more than 70 localities in eastern North America shows that large theropod dinosaurs appeared less than 10,000 years after the Triassic-Jurassic boundary and less than 30,000 years after the last Triassic taxa, synchronous with a terrestrial mass extinction. This extraordinary turnover is associated with an iridium anomaly (up to 285 parts per trillion, with an average maximum of 141 parts per trillion) and a fern spore spike, suggesting that a bolide impact was the cause. Eastern North American dinosaurian diversity reached a stable maximum less than 100,000 years after the boundary, marking the establishment of dinosaur-dominated communities that prevailed for the next 135 million years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olsen, P E -- Kent, D V -- Sues, H-D -- Koeberl, C -- Huber, H -- Montanari, A -- Rainforth, E C -- Fowell, S J -- Szajna, M J -- Hartline, B W -- New York, N.Y. -- Science. 2002 May 17;296(5571):1305-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY 10964, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016313" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; *Dinosaurs ; *Ecosystem ; Ferns ; *Fossils ; Geologic Sediments/chemistry ; Iridium/*analysis ; Meteoroids ; Minor Planets ; North America ; Spores ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A short duration of the Cretaceous-Tertiary boundary event: evidence from extraterrestrial helium-3 (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: Analyses of marine carbonates through the interval 63.9 to 65.4 million years ago indicate a near-constant flux of extraterrestrial helium-3, a tracer of the accretion rate of interplanetary dust to Earth. This observation indicates that the bolide associated with the Cretaceous-Tertiary (K-T) extinction event was not accompanied by enhanced solar system dustiness and so could not have been a member of a comet shower. The use of helium-3 as a constant-flux proxy of sedimentation rate implies deposition of the K-T boundary clay in (10 +/- 2) x 10(3) years, precluding the possibility of a long hiatus at the boundary and requiring extremely rapid faunal turnover.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukhopadhyay, S -- Farley, K A -- Montanari, A -- New York, N.Y. -- Science. 2001 Mar 9;291(5510):1952-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA. sujoy@gps.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11239153" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Geochemical evidence for a comet shower in the late Eocene (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: Analyses of pelagic limestones indicate that the flux of extraterrestrial helium-3 to Earth was increased for a 2.5-million year (My) period in the late Eocene. The enhancement began approximately 1 My before and ended approximately 1.5 My after the major impact events that produced the large Popigai and Chesapeake Bay craters approximately 36 million years ago. The correlation between increased concentrations of helium-3, a tracer of fine-grained interplanetary dust, and large impacts indicates that the abundance of Earth-crossing objects and dustiness in the inner solar system were simultaneously but only briefly enhanced. These observations provide evidence for a comet shower triggered by an impulsive perturbation of the Oort cloud.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farley, K A -- Montanari, A -- Shoemaker, E M -- Shoemaker, C S -- New York, N.Y. -- Science. 1998 May 22;280(5367):1250-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geological and Planetary Sciences, California Institute of Technology, MS 170-25, Pasadena, CA 91125, USA. farley@gps.caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9596575" target="_blank"〉PubMed〈/a〉
    Keywords: Cosmic Dust ; *Earth (Planet) ; Evolution, Planetary ; Geologic Sediments/*chemistry ; Helium ; Isotopes ; *Meteoroids
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Iridium profile for 10 million years across the Cretaceous-Tertiary boundary at Gubbio (Italy) (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-12-21
    Description: The iridium anomaly at the Cretaceous-Tertiary (KT) boundary was discovered in the pelagic limestone sequence at Gubbio on the basis of 12 samples analyzed by neutron activation analysis (NAA) and was interpreted as indicating impact of a large extraterrestrial object at exactly the time of the KT mass extinction. Continuing controversy over the shape of the Ir profile at the Gubbio KT boundary and its interpretation called for a more detailed follow-up study. Analysis of a 57-meter-thick, 10-million-year-old part of the Gubbio sequence using improved NAA techniques revealed that there is only one Ir anomaly at the KT boundary, but this anomaly shows an intricate fine structure, the origin of which cannot yet be entirely explained. The KT Ir anomaly peaks in a 1-centimeter-thick clay layer, where average Ir concentration is 3000 parts per trillion (ppt); this peak is flanked by tails with Ir concentrations of 20 to 80 ppt that rise above a background of 12 to 13 ppt. The fine structure of the tails is probably due in part to lateral reworking, diffusion, burrowing, and perhaps Milankovitch cyclicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarez, W -- Asaro, F -- Montanari, A -- DE-AC03-76SF00098/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1990 Dec 21;250:1700-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology and Geophysics, University of California, Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11538083" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Calcium Carbonate/*chemistry ; Extraterrestrial Environment ; Geological Phenomena ; *Geology ; Iridium/*analysis ; Italy ; Paleontology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Coeval 40Ar/39Ar Ages of 65.0 Million Years Ago from Chicxulub Crater Melt Rock and Cretaceous-Tertiary Boundary Tektites (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-08-14
    Description: (40)Ar/(39)Ar dating of drill core samples of a glassy melt rock recovered from beneath a massive impact breccia contained within the 180-kilometer subsurface Chicxulub crater in Yucatan, Mexico, has yielded well-behaved incremental heating spectra with a mean plateau age of 64.98 +/- 0.05 million years ago (Ma). The glassy melt rock of andesitic composition was obtained from core 9 (1390 to 1393 meters) in the Chicxulub 1 well. The age of the melt rock is virtually indistinguishable from (40)Ar/(39)Ar ages obtained on tektite glass from Beloc, Haiti, and Arroyo el Mimbral, northeastern Mexico, of 65.01 +/- 0.08 Ma (mean plateau age for Beloc) and 65.07 +/- 0.10 Ma (mean total fusion age for both sites). The (40)Ar/(39)Ar ages, in conjunction with geochemical and petrological similarities, strengthen the recent suggestion that the Chicxulub structure is the source for the Haitian and Mexican tektites and is a viable candidate for the Cretaceous-Tertiary boundary impact site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swisher, C C 3rd -- Grajales-Nishimura, J M -- Montanari, A -- Margolis, S V -- Claeys, P -- Alvarez, W -- Renne, P -- Cedillo-Pardoa, E -- Maurrasse, F J -- Curtis, G H -- Smit, J -- McWilliams, M O -- New York, N.Y. -- Science. 1992 Aug 14;257(5072):954-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789640" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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