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  • Cells, Cultured  (42)
  • American Association for the Advancement of Science (AAAS)  (42)
  • Wiley
  • 1980-1984  (42)
  • 1981  (42)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (42)
  • Wiley
Years
  • 1980-1984  (42)
Year
  • 1
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Radiosensitivity of human cells in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furcinitti, P S -- Todd, P -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209518" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/*radiation effects ; Cells, Cultured ; Dose-Response Relationship, Radiation ; HeLa Cells/radiation effects ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Voltage clamp studies in macrophages from mouse spleen cultures (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: Voltage clamp studies of macrophages from cultures of mouse spleen macrophages produced N-shaped steady-state current-voltage curves containing a region of negative slope resistance. Some macrophages exhibit two stable states of membrane potential, having current-voltage relationships that cross the voltage axis at three points. Outward currents that turn on at voltages of +15 millivolts or greater were noted in several cells. The addition of barium chloride to the bathing medium abolished the negative slope resistance and reduced the inward currents in response to hyperpolarizing voltage steps. These data provide direct evidence that macrophages exhibit at least tow different voltage-dependent conductances and demonstrate that voltage clamp techniques can be useful in studying the membrane properties of leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallin, E K -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):458-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/pharmacology ; Cell Membrane/physiology ; Cells, Cultured ; Electric Conductivity ; Macrophages/*physiology ; Membrane Potentials ; Mice ; Spleen/cytology
    Print ISSN: 0036-8075
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  • 4
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    Multiple opiate receptors: alcohol selectively inhibits binding to delta receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: The addition of ethanol or other aliphatic alcohols to rat brain membranes strongly inhibits binding of enkephalins at concentrations at which little inhibition of opiate alkaloids is seen. Inhibition is reversible, and potency increases with chain length of the alcohol. The results suggest that delta receptors are considerably more sensitive to alcohols than mu receptors. This is the first demonstration of selective inhibition of one of the postulated classes of opiate receptors by a reagent that is not a ligand for the receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiller, J M -- Angel, L M -- Simon, E J -- DA-00017/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270788" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohols/*pharmacology ; Animals ; Brain/metabolism ; Cells, Cultured ; In Vitro Techniques ; Neuroblastoma/metabolism ; Rats ; Receptors, Opioid/classification/*drug effects/metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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  • 5
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    Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenzo, J A -- Raisz, L G -- AM 07290/AM/NIADDK NIH HHS/ -- AM 18063/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1157-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Bone Resorption/*drug effects ; Bone and Bones/drug effects/*metabolism ; Calcimycin/*pharmacology ; Calcium/metabolism ; Calcium Radioisotopes ; Cells, Cultured ; DNA/*biosynthesis ; DNA Replication/*drug effects ; Ethers/pharmacology ; Fetus ; Ionomycin ; Ionophores/pharmacology ; Kinetics ; Mice ; Parathyroid Hormone/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udeinya, I J -- Schmidt, J A -- Aikawa, M -- Miller, L H -- Green, I -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017935" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus ; Cells, Cultured ; Endothelium/microbiology ; Erythrocytes/*microbiology/ultrastructure ; Female ; Humans ; Microscopy, Electron ; Plasmodium falciparum/*pathogenicity ; Pregnancy ; Umbilical Veins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Hormonal requirements for growth of arterial smooth muscle cells in vitro: and endocrine approach to atherosclerosis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, R -- Stemerman, M B -- Maciag, T -- AM 07026/AM/NIADDK NIH HHS/ -- HL 06197/HL/NHLBI NIH HHS/ -- HL 07374/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):818-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7013068" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Abdominal/cytology ; Cell Division/drug effects ; Cells, Cultured ; Culture Media ; Growth Substances/pharmacology ; Hormones/*pharmacology ; Insulin/pharmacology ; Muscle, Smooth, Vascular/*cytology ; Rats ; Transferrin/pharmacology
    Print ISSN: 0036-8075
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  • 8
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    Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrett, J C -- Wong, A -- McLachlan, J A -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzo(a)pyrene ; Benzopyrenes ; Carcinogens ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Cricetinae ; Diethylstilbestrol/*pharmacology ; Embryo, Mammalian ; Genes/*drug effects ; Mesocricetus ; *Mutation
    Print ISSN: 0036-8075
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  • 9
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    Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-13
    Description: 3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-L1 fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-L1 fibroblasts to fat cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiang, P K -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1164-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466386" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*cytology ; Animals ; Carnitine/pharmacology ; Cell Differentiation/*drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Fibroblasts/cytology ; Methylation ; Mice ; Ribonucleosides/*pharmacology ; Tubercidin/*pharmacology
    Print ISSN: 0036-8075
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  • 10
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    A conjugate of alpha-amanitin and monoclonal immunoglobulin G to Thy 1.2 antigen is selectively toxic to T lymphoma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-18
    Description: A covalent conjugate of an alpha-amanitin azo derivative and a monoclonal immunoglobulin G to the Thy 1.2 antigen on murine T lymphocytes was synthesized. The conjugate was 375- to 750-fold more inhibitory to murine T lymphoma S49.1 cells than the unconjugated derivative. At 0.7 X 10(-7) to 1.5 X 10(-7) M and at 4 X 10(-7) M amanitin equivalents, the conjugate inhibited protein synthesis in S49.1 cells by 50 percent and 80 to 96 percent, respectively. At these concentrations, mutant Thy l-deficient S49 cells and other murine lymphoma lacking Thy l altogether or carrying Thy 1.1 antigens were unaffected. This result demonstrated the potential for targeting amanitin to specific cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M T -- Preston, J F 3rd -- R01 CA 19043/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6115471" target="_blank"〉PubMed〈/a〉
    Keywords: Amanitins/*administration & dosage ; Amino Acids/metabolism ; Animals ; Antibodies/administration & dosage ; Antibodies, Monoclonal ; Antigens, Surface/*immunology ; Antigens, Thy-1 ; Cells, Cultured ; Clone Cells/immunology ; Hybrid Cells/immunology ; Immunoglobulin G/*administration & dosage ; Lymphoma/*drug therapy ; Membrane Proteins/*immunology ; Mice ; Neoplasms, Experimental/drug therapy ; T-Lymphocytes/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Lateral diffusion of surface molecules in animal cells and tissues (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-21
    Description: When bound to cell surfaces, certain lectins such as concanavalin A induce a drop in the average diffusion coefficients (D) of a number of cell surface molecules. To find whether such anchorage modulation occurs naturally, D of surface antigens on different cell and tissue types were measured by fluorescence photobleaching recovery. Values for cells of the same tissue origin under different conditions of growth and association - in tissues, in small aggregates, and as isolated cells - varied by less than twofold when polyspecific monovalent antibodies to cell surface antigens were used, a range much less than the sixfold decrease in D observed after lectin-induced anchorage modulation. Thus, if reversible modulation of the diffusion rate is used naturally as a means of cell signaling, it must involve only a few kinds of surface receptors not detected by the antibodies used in this study. In certain tissues, however, a significant proportion of cells showed no apparent receptor mobility. This "all or none" modulation of lateral diffusion may reflect relatively long-lasting alterations in the states of a single cell type or differentiation among the cells of the particular tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gall, W E -- Edelman, G M -- AI-09273/AI/NIAID NIH HHS/ -- AI-11378/AI/NIAID NIH HHS/ -- AM-04256/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):903-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Surface/physiology ; Cell Adhesion ; Cell Division ; Cells, Cultured ; Chick Embryo ; Cytoskeleton/physiology ; Diffusion ; *Membrane Fluidity ; Mice
    Print ISSN: 0036-8075
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  • 12
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    Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: The spontaneous rhythmic activity of aggregates of embryonic chick heart cells was perturbed by the injection of single current pulses and periodic trains of current pulses. The regular and irregular dynamics produced by periodic stimulation were predicted theoretically from a mathematical analysis of the response to single pulses. Period-doubling bifurcations, in which the period of a regular oscillation doubles, were predicted theoretically and observed experimentally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guevara, M R -- Glass, L -- Shrier, A -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1350-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chick Embryo ; Electric Stimulation ; Heart/*physiology ; In Vitro Techniques ; Membrane Potentials ; Models, Biological ; *Myocardial Contraction ; Periodicity
    Print ISSN: 0036-8075
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  • 13
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    Epidermal growth factors enhances viral transformation of granulosa cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, J -- Auersperg, N -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):218-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264597" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Viral/*drug effects ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Female ; Granulosa Cells/*cytology/drug effects ; Kirsten murine sarcoma virus/drug effects/*genetics ; Peptides/*pharmacology ; Rats ; Sarcoma Viruses, Murine/*genetics
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  • 14
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    Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heldin, C H -- Wasteson, A -- Fryklund, L -- Westermark, B -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1122-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6973821" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Growth Substances/*pharmacology ; Humans ; Neuroglia ; Peptides/*pharmacology ; Somatomedins/*pharmacology ; Structure-Activity Relationship
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  • 15
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    Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. Spike generation was blocked by MnCl2. In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCann, F V -- Pettengill, O S -- Cole, J J -- Russell, J A -- Sorenson, G D -- CA 25845/CA/NCI NIH HHS/ -- DA 23108/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262914" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Calcium/pharmacology ; Carcinoma, Small Cell/*physiopathology ; Cells, Cultured ; Electric Conductivity ; Humans ; Lung Neoplasms/*physiopathology ; Manganese/pharmacology ; Membrane Potentials/drug effects
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  • 16
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    Fc and C3b receptors on pulmonary endothelial cells: induction by injury (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Receptors for the activated third component of complement and for the Fc portion of immunoglobulin G are not expressed by apparently normal bovine pulmonary endothelial cells, but are expressed when the cells are exposed to white cell lysates or are infected with influenza or cytomegalovirus. The unmasking of these latent receptors may contribute to the pulmonary inflammatory response characteristic of, for example, anaphylaxis and to those lung diseases characterized by the deposition of immune complexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryan, U S -- Schultz, D R -- Ruan, J W -- HL 21568/HL/NHLBI NIH HHS/ -- HL 22087/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):557-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Cells, Cultured ; Complement C3b/metabolism ; Cytomegalovirus Infections/physiopathology ; Endothelium/metabolism ; Orthomyxoviridae Infections/physiopathology ; Pulmonary Artery/*cytology ; Receptors, Complement/*metabolism ; Receptors, Fc/*metabolism
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  • 17
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    Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. It has no effect on basal or stimulated growth hormone release from primary cultures of rat adenohypophyseal cells during a 4-hour incubation, but inhibits stimulated release by more that 90 percent after 24 hours. These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berelowitz, M -- Szabo, M -- Frohman, L A -- Firestone, S -- Chu, L -- Hintz, R L -- AM 18722/AM/NIADDK NIH HHS/ -- AM 24085/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1279-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262917" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bucladesine/pharmacology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Feedback ; Growth Hormone/pharmacology/*secretion ; Hypothalamus/drug effects/*physiology ; Insulin-Like Growth Factor I ; Kinetics ; Pituitary Gland, Anterior/drug effects/*secretion ; Rats ; Somatomedins/*pharmacology
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  • 18
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    Regeneration of neurites on long-term cultures of sympathetic neurons deprived of nerve growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Sympathetic neurons from newborn rats, cultured for 1 month or longer in the virtual absence of nonneuronal cells, were capable of regenerating neurites after neuritotomy. Regeneration occurred even after nerve growth factor was withdrawn from the cultures, although it was much less extensive and appeared limited to a few days following neuritotomy. Even after 29 days of nerve growth factor deprivation, reintroduction of the protein prompted a resumption of neurite growth. Possible roles of both nerve growth factor-independent and -dependent components in adult nerve regeneration are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Campenot, R B -- NS15559/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):579-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/drug effects ; Cells, Cultured ; Ganglia, Sympathetic/*cytology ; Nerve Growth Factors/*pharmacology ; Nerve Regeneration/*drug effects ; Neurons/*cytology ; Rats ; Time Factors
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  • 19
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    DNA synthesis in cultured adult cardiocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Trypsin-dissociated atrial cardiocytes from adult rats were exposed to [3H]thymidine for sequential 24-hour periods from day 2 to day 12 of culture. On day 3 and each day thereafter, cells were prepared for ultrastructural radioautography and examined with an electron microscope. Maximal incorporation occurred on day 5, when 63 percent of the cardiocytes were labeled. Mitotic activity was never present in more than 0.5 percent of the cardiocytes examined. Incorporation of [3H]thymidine and mitosis occurred only in immature cardiocytes characterized by subsarcolemmal primary filaments and Z bands with or without specific granules; more mature cardiocytes were never labeled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantin, M -- Ballak, M -- Beuzeron-Mangina, J -- Anand-Srivastava, M B -- Tautu, C -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):569-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; Female ; Mitosis ; Myocardium/*cytology ; Rats ; Rats, Inbred Strains ; Time Factors
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  • 20
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    Growth arrest and morphological change of human breast cancer cells by dibutyryl cyclic AMP and L-arginine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: The growth in vitro of human breast cancer cells, line MCF-7, was inhibited by a daily supplement of L-arginine (1 milligram per milliliter). Arginine acted synergistically with dibutyryl adenosine 3',5'-monophosphate (cyclic AMP) (10(-6) molar) to enhance the growth inhibitory effect: the cell replication ceased completely within 2 days after treatment. The growth arrest accompanied a change in cell morphology and was preceded by increases in the cellular concentration of cyclic AMP, adenylate cyclase, and type II cyclic AMP-dependent protein kinase activities as well as a decrease of estrogen binding activity. The results suggest that growth of human breast cancer cells is subject to cyclic AMP-mediated regulation and that arginine may play a specific role in this process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho-Chung, Y S -- Clair, T -- Bodwin, J S -- Berghoffer, B -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6269181" target="_blank"〉PubMed〈/a〉
    Keywords: Arginine/*pharmacology ; Breast Neoplasms/metabolism/*pathology ; Bucladesine/*pharmacology ; Cell Division/*drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Cyclic AMP/metabolism ; Drug Synergism ; Female ; *Growth Inhibitors ; Humans
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  • 21
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    Interferon-resistant cell line lacks fatty acid cyclooxygenase activity (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-04-17
    Description: A clone of L1210 mouse leukemia cells selected for resistance to both the antiviral and anticellular properties of mouse interferon were essentially devoid of fatty acid cyclooxygenase activity. Experiments in which broken cell preparations were mixed or the two cell types were cultivated together failed to indicate the presence of a diffusible enzyme inhibitor. Fatty acid lipoxygenase activity of similar magnitude was detectable in both cell types. A selective impairment of fatty acid cyclooxygenase in interferon-resistant cells is consistent with recently described data suggesting that this enzyme may play a crucial role in mediating the antiviral and anticellular effects of interferon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chandrabose, K A -- Cuatrecasas, P -- Pottathil, R -- Lang, D J -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163214" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism ; Cells, Cultured ; Clone Cells/drug effects/enzymology ; Cyclooxygenase Inhibitors ; Interferons/*pharmacology ; Leukemia L1210 ; Lipoxygenase/metabolism ; Lipoxygenase Inhibitors ; Mice ; Prostaglandin-Endoperoxide Synthases/*deficiency ; Prostaglandins/biosynthesis
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  • 22
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    Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-22
    Description: This study suggests one mechanism by which alveolar macrophages accumulate in the lung in pulmonary emphysema: elastin fragments generated at the diseased sites are potent chemoattractants for monocytes, the precursors of the macrophages. The most chemotactic elastin fragments have a molecular weight between 10,000 and 50,000 and are active at concentrations as low as 3 nanograms per milliliter. By comparison, elastin fragments with higher molecular weights and desmosines are active at concentrations greater than 0.3 microgram per milliliter. In addition, preincubation of monocytes with the 10,000- to 50,000-dalton elastin impairs the ability of the cells to migrate toward elastin fragments but not toward activated serum. Fragments of tropoelastin are not chemotactic for monocytes. Because elastin, but not tropoelastin, contains lysyl-derived cross-links, these structures may be the active chemotactic site on the elastin fragments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunninghake, G W -- Davidson, J M -- Rennard, S -- Szapiel, S -- Gadek, J E -- Crystal, R G -- New York, N.Y. -- Science. 1981 May 22;212(4497):925-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233186" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Chemotaxis, Leukocyte/*drug effects ; Dose-Response Relationship, Drug ; Elastin/*analogs & derivatives/*pharmacology ; Humans ; Macrophages/physiology ; Monocytes/*physiology ; Peptide Fragments/pharmacology ; Pulmonary Emphysema/*physiopathology ; Structure-Activity Relationship ; Tropoelastin/*pharmacology
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  • 23
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    Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maxfield, F R -- Willingham, M C -- Pastan, I -- Dragsten, P -- Cheng, S Y -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):63-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6255563" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/*metabolism ; Cells, Cultured ; Cytoplasmic Granules/metabolism ; Diffusion ; Endocytosis ; Kinetics ; Membrane Fluidity ; Membrane Proteins/metabolism ; Mice ; Microscopy, Fluorescence ; Receptors, Cell Surface/*metabolism ; Receptors, Thyroid Hormone ; Triiodothyronine/*metabolism
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  • 24
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    The posterior pituitary: regulation of anterior pituitary prolactin secretion (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: Removal of the posterior pituitary from anesthetized male rats results in a prompt and significant increase in circulating prolactin that is reversed by the injection of dopamine. Posterior pituitary extracts, which contain high concentrations of endogenous dopamine, inhibit prolactin secretion from isolated anterior pituitary cells. This inhibition is prevented by incubation of the cells with the dopamine receptor antagonist (+)-butaclamol. The data show that posterior pituitary dopamine reaches the anterior pituitary via the short hypophysial portal vessels and participates in the regulation of prolactin secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, L L -- Hoefer, M T -- Ben-Jonathan, N -- HD 14348/HD/NICHD NIH HHS/ -- NS-13234/NS/NINDS NIH HHS/ -- NS-219/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Dopamine/pharmacology/*physiology ; Luteinizing Hormone/secretion ; Male ; Pituitary Gland, Posterior/*physiology ; Prolactin/*secretion ; Rats ; Secretory Rate/drug effects
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  • 25
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    Compartmentalization of cyclic AMP during phagocytosis by human neutrophilic granulocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-23
    Description: Immunocytochemistry shows that early during phagocytosis of zymosan, adenosine 3',5'-monophosphate (cyclic AMP) appears on the cell surface before the phagosome is internalized. The appearance of cyclic AMP on the cell surface is coincident with that of granule products and regulatory subunit of type I cyclic AMP-dependent protein kinase. Guanosine 3',5'-monophosphate is not associated with the initiation site of phagocytosis, but is observed throughout the granular cytoplasmic region. This sharply localized accumulation of cyclic AMP may serve as a signal for the initiation of phagocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pryzwansky, K B -- Steiner, A L -- Spitznagel, J K -- Kapoor, C L -- 02430-22/PHS HHS/ -- AM17438/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 23;211(4480):407-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6261328" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Compartmentation ; Cells, Cultured ; Cyclic AMP/*metabolism ; Cyclic GMP/metabolism ; Cytoplasmic Granules/metabolism ; Humans ; Lactoferrin/metabolism ; Macromolecular Substances ; Neutrophils/*physiology/ultrastructure ; Peroxidase/metabolism ; *Phagocytosis ; Protein Kinases/metabolism
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  • 26
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    Lectins mimic insulin in the induction of tyrosine aminotransferase (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: Various lectins were found to induce tyrosine aminotransferase in H-35 rat hepatoma cells grown in monolayer culture. Wheat germ agglutinin gave a maximal induction of tyrosine aminotransferase 6 hours after its addition. The induction time course was similar to that elicited by insulin. Fourteen micrograms of wheat germ agglutinin per milliliter gave half-maximal enzyme induction and 50 micrograms per milliliter gave the maximal response. The induction of tyrosine aminotransferase by wheat germ agglutinin was additive with the induction by either dexamethasone or dibutyryl adenosine 3',5'-monophosphate, but was not additive with the tyrosine amino transferase induction by insulin. Wheat germ agglutinin also mimicked insulin in the inhibition of cellular protein degradation in the absence of serum. The insulin-like effects of lectins should be considered in lectin-mediated manipulations such as agglutination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J D -- Liu, A Y -- AM20274/AM/NIADDK NIH HHS/ -- GM 07258/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):799-800.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117128" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bucladesine/pharmacology ; Cells, Cultured ; Dexamethasone/pharmacology ; Enzyme Induction/drug effects ; Insulin/*pharmacology ; Lectins/*pharmacology ; Liver/*enzymology ; Liver Neoplasms, Experimental/enzymology ; Peptide Hydrolases/metabolism ; Rats ; Receptor, Insulin/drug effects ; Tyrosine Transaminase/*biosynthesis
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  • 27
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    Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-05-22
    Description: The molecularly cloned, long terminal repeat (LTR) of the Moloney sarcoma virus (M-MSV) provirus has been covalently linked to c-mos, the cellular homolog of the M-MSV-specific sequence, v-mos. These newly constructed clones lack any M-MSV-derived sequences other than the LTR, but in DNA transfection assays they transform cells as efficiently as cloned subgenomic M-MSV fragments containing both v-mos and LTR. Cells transformed by LTR:c-mos hybrid molecules contain additional copies of mos DNA, and several size classes of polyadenylated RNA's with sequence homology to mos. The activation of the transforming potential of c-mos by the proviral LTR suggests a model whereby LTR-like elements could activate other normal cell sequences with oncogenic potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blair, D G -- Oskarsson, M -- Wood, T G -- McClements, W L -- Fischinger, P J -- Vande Woude, G G -- New York, N.Y. -- Science. 1981 May 22;212(4497):941-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233190" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Viral ; Cells, Cultured ; DNA, Recombinant ; Defective Viruses/genetics ; Gene Expression Regulation ; *Genes, Viral ; Mice ; Moloney murine leukemia virus/*genetics ; Nucleic Acid Hybridization ; Operon ; Plasmids
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  • 28
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    Regulation of muscle differentiation: stimulation of myoblast fusion in vitro by catecholamines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: Epinephrine and isoproterenol provoke primary chick myoblasts to initiate precocious cell fusion. Both the rise in intracellular adenosine 3' ,5-monophosphate (cyclic AMP) and cell fusion generated by these effectors are prevented by propranolol, which is a specific blocker of the beta-adrenergic receptor. Propranolol has no effect either on the precocious cell fusion provoked by prostaglandin E or on cell fusion in control cultures. The results support the idea that a rise in cyclic AMP is the critical intracellular change responsible for initiating events that culminate in myoblast differentiation 4 to 5 hours later. They also indicate that the culminate in myoblast differentiation 4 to 5 hours later. They also indicate that the hormone responsible for the positive regulation of myoblast differentiation in vitro is not acting through the beta-adrenergic receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curtis, D H -- Zalin, R J -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1355-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274017" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catecholamines/*pharmacology ; Cell Differentiation/drug effects ; Cell Fusion/*drug effects ; Cells, Cultured ; Chick Embryo ; Cyclic AMP/metabolism ; Epinephrine/pharmacology ; Isoproterenol/pharmacology ; Muscles/*cytology ; Propranolol/pharmacology ; Prostaglandins E/pharmacology ; Receptors, Adrenergic, beta/drug effects ; Stimulation, Chemical
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  • 29
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    Tritiated thymidine incorporation does not measure DNA synthesis in ribavirin-treated human cells (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-05-01
    Description: When the incorporation of tritiated thymidine into acid insoluble material was measured, ribavirin appeared to be a potent inhibitor of DNA synthesis in KB cells and human lymphocytes. Inhibition was nearly 100-fold less, however, when DNA synthesis was measured by incorporation of phosphorus-32-labeled phosphate or by DNA fluorescence. The potent inhibition detected by incorporation of tritiated thymidine into DNA actually was the result of a potent effect on the labeling of deoxythymidine triphosphate, not on the synthesis of DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drach, J C -- Thomas, M A -- Barnett, J W -- Smith, S H -- Shipman, C Jr -- DE 02731/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):549-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209549" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; DNA/*biosynthesis ; DNA Replication/*drug effects ; Humans ; Lymphocytes/metabolism ; Phosphates/metabolism ; Ribavirin/*pharmacology ; Ribonucleosides/*pharmacology ; Thymidine/*metabolism ; Thymine Nucleotides/biosynthesis
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  • 30
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    Optical recording of calcium action potentials from growth cones of cultured neurons with a laser microbeam (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Simultaneous recordings of calcium action potentials directly from growth cones and from somata of neuroblastoma cells indicated that they could be generated in the neurites at or near growth cones. Growth cone responses were measured with a fluorescent voltage-sensitive dye and a 5-milliwatt helium-neon laser microbeam as a monitoring light source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grinvald, A -- Farber, I C -- NS14716/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1164-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233210" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Calcium/*pharmacology ; Cells, Cultured ; Chickens ; Evoked Potentials/drug effects ; Kinetics ; Lasers ; Microscopy, Fluorescence ; Neurons/drug effects/*physiology
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  • 31
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    Suppression of immunity by stress: effect of a graded series of stressors on lymphocyte stimulation in the rat (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-18
    Description: In rats a graded series of stressors produced progressively greater suppression of lymphocyte function, as measured by the number of circulating lymphocytes and by phytohemagglutinin stimulation of lymphocytes in whole blood and isolated cultures. This evidence suggests that stress suppresses immunity in proportion to the intensity of the stressor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keller, S E -- Weiss, J M -- Schleifer, S J -- Miller, N E -- Stein, M -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6973822" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Electroshock ; *Immune Tolerance ; Leukocyte Count ; Lymphocyte Activation ; Phytohemagglutinins/pharmacology ; Rats ; Stress, Physiological/*immunology ; T-Lymphocytes/immunology
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  • 32
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    Gonadotropin-releasing hormone: regulation of adenosine 3',5'-monophosphate in ovarian granulosa cells (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-18
    Description: The antigonadal effects of gonadotropin-releasing hormone in ovarian granulosa cells are due to attenuation of the adenosine 3',5'-monophosphate (cyclic AMP) response to follicle-stimulating hormone. Agonists of gonadotropin-releasing hormone progressively inhibit adenylate cyclase and stimulate phosphodiesterase activities in cultured granulosa cells, indicating that blockade of gonadotropin action is attributable to the combined effects of decreased production and increased degradation of cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knecht, M -- Catt, K J -- 5 F32 HDO5801/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6274016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Cyclic AMP/*metabolism ; Enzyme Activation/drug effects ; Female ; Follicle Stimulating Hormone/antagonists & inhibitors ; *Granulosa Cells/*drug effects/metabolism ; *Hypophysectomy ; Phosphodiesterase Inhibitors/*pharmacology ; Phosphoric Diester Hydrolases/*metabolism ; Pituitary Hormone-Releasing Hormones/*pharmacology ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Specific antigen in serum of patients with colon carcinoma (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koprowski, H -- Herlyn, M -- Steplewski, Z -- Sears, H F -- CA-21124/CA/NCI NIH HHS/ -- RR-05540/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):53-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6163212" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Adult ; Aged ; Antibodies, Neoplasm/immunology ; Antibody Specificity ; Antigens, Neoplasm/*analysis ; Binding, Competitive ; Carcinoembryonic Antigen/analysis ; Cells, Cultured ; Colonic Neoplasms/*immunology ; Epitopes ; Female ; Humans ; Intestinal Diseases/immunology ; Male ; Middle Aged ; Neoplasms/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 34
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    Increased pyrophosphate in fibroblasts and lymphoblasts from patients with hereditary diffuse articular chondrocalcinosis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: The metabolic and genetic factors leading to deposition of calcium pyrophosphate crystals in cartilage of patients with chondrocalcinosis are not well understood. Analysis of cultured fibroblasts and lymphoblasts from 12 affected members of a large kindred showed a mean concentration of intracellular inorganic pyrophosphate two times greater than that in cells from unaffected family members or normal, unrelated volunteers. Increased intracellular pyrophosphate may, therefore, be a biochemical marker for the heterozygous expression of the chondrocalcinosis gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lust, G -- Faure, G -- Netter, P -- Seegmiller, J E -- AM13622/AM/NIADDK NIH HHS/ -- GM17702/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):809-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270793" target="_blank"〉PubMed〈/a〉
    Keywords: Cells, Cultured ; Chondrocalcinosis/genetics/*metabolism ; Diphosphates/*metabolism ; Fibroblasts/*metabolism ; Humans ; Lymphocytes/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Cellular aging: further evidence for the commitment theory (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: A large, transient reduction in the population size of human fibroblasts in early passages significantly increases the variability of the life-spans of cultures in comparison to control cultures, as predicted by the commitment theory of cellular aging. The theory also predicts that a constant population of noncycling cells will appear in the later part of the culture life-span. This was confirmed by labeling the cells in culture with tritiated thymidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holliday, R -- Huschtscha, L I -- Kirkwood, T B -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280670" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Division ; *Cell Survival ; Cells, Cultured ; Fibroblasts/*physiology ; Humans ; Lung/cytology ; Probability
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  • 36
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    Choline stimulates nicotinic receptors on adrenal medullary chromaffin cells to induce catecholamine secretion (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: Choline stimulated secretion of catecholamines from primary dissociated cultures of bovine adrenal medullary chromaffin cells by interacting with nicotinic receptors. Secretion was readily detected at a choline concentration of 1 millimole per liter and was maximal at 3 to 10 millimoles per liter; it was completely calcium-dependent. Further analysis suggested that choline acts as a partial nicotinic agonist.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holz, R W -- Senter, R A -- 1 ROAM-27959-01/OA/SAMHSA HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):466-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291988" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/antagonists & inhibitors ; Adrenal Medulla/*physiology ; Animals ; Catecholamines/*secretion ; Cattle ; Cells, Cultured ; Choline/*pharmacology ; Chromaffin System/*physiology ; Exocytosis/drug effects ; Receptors, Cholinergic/*drug effects ; Receptors, Nicotinic/*drug effects
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  • 37
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    Contractility of bile canaliculi: implications for liver function (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: Dynamic contractions of bile canaliculi were observed in groups of cultured hepatocytes by time-lapse cinephotomicrography during the early stages of monolayer formation. The contractions, which were forceful and appeared to have a pumping action, may facilitate the flow of bile in the liver's canalicular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oshio, C -- Phillips, M J -- New York, N.Y. -- Science. 1981 May 29;212(4498):1041-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bile/*physiology ; Cells, Cultured ; Cytoskeleton/*physiology/ultrastructure ; Liver/*physiology ; Male ; Microscopy, Phase-Contrast ; Rats
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    Journey to the center of the cell: role of the receptosome (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Fibroblasts contain a specific internalization pathway that carries hormones as well as some proteins and viruses from the cell surface to the cell interior. Initially, the ligands bind to mobile receptors that are randomly distributed on the cell surface. Next the ligand-receptor complexes are trapped and concentrated in specialized regions of the membrane termed bristle-coated pits. From the pit a smooth-walled vesicle containing the ligand forms and carries the ligand to the cell interior. Because of its role in receptor-mediated endocytosis, this vesicle has been termed a "receptosome."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pastan, I H -- Willingham, M C -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):504-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6170111" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Compartmentation ; Cells, Cultured ; Clathrin ; Cytoplasm/physiology ; *Endocytosis ; Exocytosis ; Fibroblasts/*physiology ; Ligands ; Membrane Fluidity ; Membrane Proteins/metabolism ; Mice ; Microscopy, Fluorescence ; Receptors, Drug/*physiology ; alpha-Macroglobulins/metabolism ; gamma-Glutamyltransferase/metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Ganglioside stimulation of axonal sprouting in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Bovine brain gangliosides were applied to primary and established neuronal cultures to examine the role of gangliosides in neuronal development. Media containing gangliosides enhanced the degree of axonal elongation exhibited by sensory ganglia neurons and increased the length and number of Neuro-2a neuroblastoma cell processes. Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems. These experiments suggest that gangliosides function as acceptor molecules for growth-promoting substances in embryonic and tumor-derived neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roisen, F J -- Bartfeld, H -- Nagele, R -- Yorke, G -- NS 11299/NS/NINDS NIH HHS/ -- NS 11605/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):577-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Cells, Cultured ; Chick Embryo ; Enzyme Induction/drug effects ; Ganglia, Spinal/embryology ; Gangliosides/*physiology ; Microscopy, Electron, Scanning ; Neurons/*cytology/ultrastructure ; Ornithine Decarboxylase/biosynthesis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    Alcohol-dependent liver cell necrosis in vitro: a new model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-17
    Description: In alcoholic liver injury, necrosis is involved in the progression from benign fatty liver to alcoholic hepatitis and cirrhosis. However, there is no practical model of alcohol-dependent liver cell necrosis. The calcium-dependent killing of cultured rat hepatocytes by two different membrane-active hepatotoxins, galactosamine and phalloidin, is potentiated by ethyl alcohol. This indicates that some general physical effect of alcohol on cellular membranes renders cells susceptible to otherwise nonlethal injuries. The in vitro model described in this report may thus be used to search for a general mechanism underlying alcohol-related tissue injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schanne, F A -- Zucker, A H -- Farber, J L -- Rubin, E -- AA 03442/AA/NIAAA NIH HHS/ -- AM 19154/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):338-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209533" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Cell Membrane/drug effects ; Cells, Cultured ; Drug Synergism ; Ethanol/pharmacology ; Female ; Galactosamine/pharmacology ; In Vitro Techniques ; Liver/drug effects ; Liver Diseases, Alcoholic/*pathology ; Necrosis ; Phalloidine/pharmacology ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Normalization by cell fusion of sister chromatid exchange in Bloom syndrome lymphocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Fusion of fresh lymphocytes from a Bloom syndrome (BS) patient with those of normal subjects or a BS heterozygote resulted in complete normalization of the frequency of sister chromatid exchanges in the chromosomes of BS cells. This normalization took place by the first mitosis in hybrid cells. In contrast, cultivation of BS lymphocytes with those of normal subjects or the BS heterozygote had no effect on sister chromatid exchanges. The cell fusion experiments suggest that the normalization on the sister chromatid exchanges. The cell fusion experiments suggest that the normalization of the sister chromatid exchange frequencies in BS cells can be achieved by factors conserved in the cells of various mammalian species. These findings are compatible with the concept that BS is a recessive genetic mutation at regulatory levels of the DNA repair function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shiraishi, Y -- Matsui, S -- Sandberg, A A -- CA-14555/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):820-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221565" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Fusion ; Cells, Cultured ; *Crossing Over, Genetic ; Humans ; Hybrid Cells/physiology ; Photosensitivity Disorders/*genetics ; *Sister Chromatid Exchange ; Syndrome ; Telangiectasis/*genetics
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  • 42
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    Toxic injury to isolated hepatocytes is not dependent on extracellular calcium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-11
    Description: Freshly isolated hepatocytes from phenobarbital-treated rats were incubated in the presence or absence of extracellular calcium with three differently acting liver cell toxins, namely carbon tetrachloride, bromobenzene, and ethylmethanesulfonate. In the absence of extracellular calcium these three compounds were far more toxic to the cells than in its presence. This result is inconsistent with the hypothesis that an influx of extracellular calcium is required as the final step in toxic liver cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, M T -- Thor, H -- Orrenius, S -- New York, N.Y. -- Science. 1981 Sep 11;213(4513):1257-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268433" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bromobenzenes/*toxicity ; Calcium/*metabolism ; Carbon Tetrachloride Poisoning/*physiopathology ; Cell Survival ; Cells, Cultured ; Ethyl Methanesulfonate/*toxicity ; Extracellular Space/metabolism ; Humans ; Liver/*drug effects/pathology ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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