Publication Date:
1981-01-02
Description:
A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maxfield, F R -- Willingham, M C -- Pastan, I -- Dragsten, P -- Cheng, S Y -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):63-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6255563" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carrier Proteins/*metabolism
;
Cells, Cultured
;
Cytoplasmic Granules/metabolism
;
Diffusion
;
Endocytosis
;
Kinetics
;
Membrane Fluidity
;
Membrane Proteins/metabolism
;
Mice
;
Microscopy, Fluorescence
;
Receptors, Cell Surface/*metabolism
;
Receptors, Thyroid Hormone
;
Triiodothyronine/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
