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  • Chemistry  (72,168)
  • Cell & Developmental Biology  (5,181)
  • EARTH RESOURCES AND REMOTE SENSING  (3,375)
  • ASTROPHYSICS  (3,362)
  • 1995-1999  (41,452)
  • 1980-1984  (42,634)
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Keywords
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Year
  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 34
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 35
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    Potential applications of GSC-2 for GAIA operations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The second guide star catalog (GSC-2) is a project that aims to create a complete catalog of stars and galaxies to about the 18th magnitude, and would contain colors, magnitudes, positions and proper motions. The catalog would provide an object list for the construction of an input catalog for possible future astrometric satellites, such as the global astrometric interferometer for astrophysics (GAIA) satellite. With a schedule that is compatible with the projected timeframe of GAIA, the GSC-2 could be available in time to support the preparatory astrophysical observations for an input catalog. The availability of the digitalized images for the preparation of finding charts would improve the efficiency of this task.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 137-141
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  • 36
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    Time delay in the Einstein ring PKS 1830-211 (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present radio observations of the gravitational lens PKS 1830-211 at 8.4 and 15 GHz acquired using the Very Large Array. The observations were made over a 13 month period. Significant flux density changes over this period provide strong constraints on the time delay between the two lensed images and suffest a value of 44 +/- 9 days. This offers new direct evidence that this source is indeed a gravitational lens. The lens distance is dependent upon the model chosen, but reasonable limits on the mass of the lensing galaxy suggest that it is unlikely to be at a redshift less than a few tenths, and may well be significantly more distant.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 2; p. 561-566
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  • 37
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    An intercomparison of plasma turbulence at three comets: Grigg-Skjellerup, Giacobini-Zinner, and Halley (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The power laws are approximately f(exp -1.9), f(exp -1.9), and f(exp -2.1) respectively for the Grigg-Shjellerup (GS), Giacobini-Zinner (GZ), and Halley (H) comets. Other than similarities in the power spectra, the magnetic field turbulence is considerably different at the three comets. Phase steepening is demonstrated to occur at the trailing edges of the GS waves. This is probably due to nonlinear steepening plus dispersion of the left-hand mode components, i.e., the turbulence is whistler-mode. This too can be explained by nonlinear steepening plus dispersion of the magnetosonic waves. At the level of GS and GZ turbulence development when the spacecraft measurements were made, classical three-wave processes, such as the decay or modulation instabilities do not appear to play important roles. It is most likely that the nonlinear steepening and dispersive time scales are more rapid than three-wave processes, and the latter had not had time to develop for the relatively new turbulence. The wave turbulence at Halley is linearly polarized. The exact nature of this turbulence is still not well understood. Several possibilities are suggested, based on a preliminary analyses.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 9; p. 1149-1152
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  • 38
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    A study of coronal X-ray emission from short-period Algol binaries (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A study of X-ray emission from five short-period Algol-type binaries based on observations with Advanced Satellite for Cosmology and Astrophysics (ASCA) and ROSAT is presented. We have observed RZ Cas with both satellites, and beta Per, U Cep, delta Lib, and TW Dra with ROSAT. Significant intensity variations are seen in the X-ray emission from RZ Cas, U Cep, TW Dra, and delta Lib. These variations seem unrelated to the eclipsing behavior of these systems and are probably due to either rotational modulation of compact active regions on the surfaces of the chromospherically active secondary components or to flaring activity in the systems. The spectra of all but one of the systems require the presence of at least two discrete plasma components with different temperatures (0.6 - 0.7 keV, and approximately 2 keV) and the abundances of the medium-Z elements 20% - 50% of the solar photospheric values. The high resolving power and signal-to-noise ratio of the ASCA spectra allow us to individually constrain the coronal abundances of O, Ne, Mg, Si, S, and Fe in RZ Cas. We demonstrate that, if we use the elemental abundances and temperatures obtained from the analysis of their ASCA spectra as (fixed) inputs, to fit the ROSAT PSPC spectra well requires the presence of a third component (kT approximately 0.2 - 0.3 keV) in RZ Cas and beta Per. A continuous emission measure model of the power-law type (EM(T) variesas (T/T(sub max)(sup alpha)) generally gives a poor fit to the ASCA and ROSAT data on most sources. Circumstellar or circumbinary absorbing matter seems to be present in some of these systems, as indicated by the variable total column density needed to fit their X-ray spectra.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 840-854
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  • 39
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    A tentative detection of the 183-GHz water vapor line in the martian atmosphere: Constraints upon the H2O abundance and vertical distribution (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The 183-GHz water vapor line was tentatively detected on Mars in January 1991, with the IRAM 30-m millimeter antenna, under extremely dry atmospheric conditions. The measurement refers to the whole disk. The spectral line, although marginally detected, can be fit with a constant H2O mixing ratio of 1.0 x 10(exp -5), which corresponds to a water abundance of 1 pr-microns; in any case, an upper limit of 3 pr-microns is inferred. This value is comparable to the very small abundances measured by Clancy (1992) 5 weeks before our observation and seems to imply both seasonal and long-term variations in the martian water cycle.
    Keywords: ASTROPHYSICS
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 110-118
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  • 40
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    Tidal dissipation in oceans on Titan (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Titan's large free eccentricity results in significant tidal dissipation. This can be used to constrain the existence and depth of hydrocarbon oceans. A hydrodynamical-numerical 2 deg ocean tide model has been constructed to investigate this connection. The model allows some simple land configurations. The results indicate that existence of such an ocean over the age of the solar system is hard to explain, as is the existence of the large eccentricity itself. If such an ocean exists, it is likely to be more than 500 m deep, ignoring the influence of land masses.
    Keywords: ASTROPHYSICS
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 39-56
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  • 41
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    Backscatter model for the unusual radar properties of the Greenland Ice Sheet (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A number of planetary objects exhibit large radar reflectivity and polarization ratios, and more recently, a similar behavior has been observed over a vast portion of the Earth's surface: the percolation facies of the Greenland Ice Sheet. Surface-based ranging radar data and snow stratigraphy studies demonstrated that the radar properties of that portion of Greenland are caused by enhanced scattering from massive, large, solid-ice bodies buried in the top few meters of the dry, cold, clean snowy surface of the ice sheet and created by seasonal melting and refreezing events. Here, we model the icy inclusions as randomly oriented, discrete, noninteracting, dielectric cylinders embedded in a transparent snow medium. An exact analytical solution is used to compute the scattered field from the cylinders. Using this model, we correctly predict the polarimetric radar observations gathered by an airborne imaging system at three wavelengths (5.6, 24, and 68 cm), between 19 deg and 65 deg incidence angle. The diameter and number density of the cylinders that are inferred from the radar data using the model are consistent with in situ observations of the icy inclusions. The large radar reflectivity and polarization ratios are interpreted as arising internal reflections of the radar signals in the icy inclusions that first-order external reflection models fail to predict. The results compare favorably with predictions from the coherent backscatter or weak localization theory and may provide a complementary framework for interpreting exotic radar echoes from other planetary objects.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E5; p. 9389-9400
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  • 42
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    Precession and nutation from joint analysis of radio interferometric and lunar laser ranging observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: 24 years of Lunar Laser Ranging (LLR) observations and 16 years of Very Long Baseline Interferometry (VLBI) observations are combined in a global analysis to yield improved estimates of the Earth's precession and nutation. The correction to the International Astronomical Union (IAU) (1976) precession constant inferred from this joint VLBI/LLR analysis is -3.00 +/- 0.20 milliarcsec/yr (mas/yr). A significant obliquity rate correction of -0.20 +/- 0.08 mas/yr is also found. In all, 32 forced nutation coefficients are estimated. These coefficients confirm that the IAU (1980) nutation theory is in error by several mas. The estimated nutation coeficients are found to vary by as much as several tenths of mas, depending on the a priori nutation model used to analyze the VLBI and LLR data. Forced circular nutations derived from this analysis agree with the ZMOA-1990-2 nutation theory at the 0.2 mas level for the 18.6 yr terms, and at the 0.05 mas level for the other terms (periods less than or = 1 yr). A retrograde free core nutation with an amplitude of 0.20 mas is also detected. Its phase is found to be very sensitive to the precise value of the free core nutation period used in the solution. Separate analyses of four independent subsets of the LVBI data indicate no significant variations of the free core nutation since 1988. The pre-1988 estimates of the free core nutation are consistent with the post-1988 estimates but are not accurate enough to rule out possible variations of the free core nutation at these earlier epochs.
    Keywords: ASTROPHYSICS
    Type: The Astronomical Journal (ISSN 0004-6256); 109; 1669; p. 418-427
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  • 43
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    Ulysses magnetic field observations of fluctuations within polar coronal flows (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Ulysses spacecraft has gathered data from within flows from the Sun's southern polar coronal hole, the first in situ measurement of this region. We present a brief analysis of the heliospheric magnetic field data from this region, using a fractal method. As is the case near the ecliptic, estimated spectral exponents are near 5/3 on spacecraft scales of seconds to minutes. On longer time scales, however, there appears to be a significantly different population in polar flows, which is similar to that found by the Helios spacecraft in fast solar wind flows at 0.3 AU.
    Keywords: ASTROPHYSICS
    Type: Annales Geophysicae (ISSN 0992-7689); 13; 1; p. 105-107
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  • 44
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    The neutral oxygen spectrum. 2: Pumping by hydrogen Lyman-beta under the optically thin condition: A first application to the classical novae (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A calculation, employing a detailed model of neutral oxygen, is carried out to give fluorescent line intensities expected in a long-proposed photoexcitation by accidental resonance (PAR) process in which hydrogen Lyman-beta photoexcites the oxygen spectrum. The results pertain to the optically thin case but provide an upper limit to the fluorescent intensities which can be attained. They are applied to analyze line ratios involving the strong 8446 A line observed in classical novae during the diffusion-enhanced and Orion phases. Operation of the PAR process in the novae is verified. It is found that photoexcitation rates in the ejecta reach values greater than 0.1/sec, corresponding to hydrogen Lyman-beta radiation field intensities greater than 1250 ergs/cm/sec/sr.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 1; p. 346-356
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  • 45
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    Physical properties of the OMC-2 and OMC-3 cores from CS and C(18)O observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have investigated the properties of the OMC-2 and OMC-3 cores in the Orion giant molecular cloud using high spatial spectral resolution observations of several transitions of the (13)CO, C(18)O, C(S-32) and C(S-34) molecules taken with the SEST telescope. The OMC-2 core consists of one clump (22 solar mass) with a radius of 0.11 pc surrounded by a cluster of 11 discrete infrared sources. The H2 column density and volume density in the center of this clump are 2 x 10(exp 22)/sq cm and 9 x 10(exp 5)/cu cm respectively. From a comparison between physical parameters derived from C(18)O and C(S-32) observations we conclude that the molecular envelope around the core has been completely removed by these sources and that only the very dense gas is left. OMC-3 shows a more complex elongated structure in C(18)O and CS than OMC-2. The C(S-32) and C(S-34) maps show that the denser region can be separated into at least sub-cores of roughly equal sizes (radius approximately equals 0.13 pc), with n(H2) = 6 x 10(exp 5)/cu cm, and a mass of 10 solar mass (from C(S-32)). The very different masses obtained for the central core from C(18)O and C(S-32) (55 and 12 solar mass respectively) indicate that a massive envelope is still present around the very dense sub-cores. We report the first detection of several molecular outflows in OMC-3. The presence of an IRAS source and the first detection of these outflows confirm that star formation is going on in OMC-3. Based on the different physical properties of these regions compared with OMC-1, OMC-2 appears to be in an intermediate evolutionary stage between OMC-1 and OMC-3.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 294; 3; p. 835-854
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    Grains in ionized nebulae: Spectral line diagnostics (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The depletion of condensable elements onto grains in gaseous nebulae can provide evidence that dust is well mixed with the ionized gas. Al and CA are two of the most depleted elements in the general interstellar medium, and it is therefore important to measure their abundances within the ionized region of nebulae. We compute a large grid of photoionization models and identify sets of line ratios which are relatively insensitive to stellar and nebular parameters, and are thus excellent diagnostics for determining relative abundances. Based on the absence of the ((Ca II) lambda lambda 291, 7324 doublet and the detection of Al II) lambda lambda 2660, 2669 in the ultraviolet, we determine the extent of aluminum and calcium depletion onto grains in NGC 7027 and the Orion Nebula. Our results show a approximately 0.3 dex depletion for Al, but a depletion of more than two and a half orders of magnitude for Ca. A similar calculation based on Mg II lambda 2798 yields roughly a 0.8 dex depletion for Mg. This reaffirms the discrepancy between depletion determined from high and low ionization Mg lines. We also find evidence for a 'depletion gradient' in Ca in NGC 7027, since the calcium depletion we infer for the outer, more neutral regions using (Ca II) is somewhat higher than that inferred for the inner high-ionization region, using (Ca v). This gradient can test current models of the survival of grains within hot ionized gas.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 793-799
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    Ice flow dynamics of the Greenland ice sheet from SAR interferometry (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Synthetic-aperture radar (SAR) interferograms produced from ESA's ERS-1 satellite, provide the first synoptic view of ice flow dynamics of the western sector of the Greenland Ice Sheet. Glacial motion is detected in the radar ranging direction at millimetric scales, across a complete sequence of snow accumulation and melting regimes, despite significant varations in their radar scattering properties. Ice flow evolves from a slow, regular motion at the higher elevations. At lower elevations, motion is strongly convoluted by meter-scale undulations in surface topography, which have a unique interferometric signature that enables a novel approach for retrieving flow direction. Inferred flow directions, combined with surface displacements in the radar ranging direction, yield ice velocity estimates that are within 6% of in-situ measurements gathered along a 40 km survey line. Application of repeat-pass SAR interferometry to the entire Greenland Ice Sheet should enable precise mapping of its ice flow dynamics at an unprecedented level of spatial detail.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 5; p. 575-578
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    On the nature of the binary radio pulsar PSR B0042-73 in the small magellanic cloud (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The modern scenario of evolution of massive binary systems predicts the existence of a subclass of binary radio pulsars (PSRs) with black holes (BHs). Their Galactic number was evaluated as approximately 1 per 1000 single pulsars (Lipunov et al. 1994b). Distinctive properties of such binaries would be (1) mass of the unseen companion M(sub c) greater than 3-4 solar mass and (2) absence of eclipses of the pulsar radiation with no distinctive variance of the dispersion measure along the pulsar orbit. The pulsars themselves must be similar to standard isolated ones. The recently discovered binary 1 s pulsar PSR B0042-73 = PSR J0045-7319 in the Small Magellanic Cloud (SMC) with a massive companion in a highly elongated (eccentricity e =0.8) 51 day orbit (Kaspi et al. 1994) may be the first such pulsar with a BH. The paradoxical fact that the first pulsar discovered in the SMC proved to be in a binary system can be naturally understood if its companion actually is a 10-30 solar mass black hole. We illustrate this fact by the numerical calculation of evolution of radio pulsars after a star formation burst.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 776-778
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    Optically thin accretion disks in the Kerr metric (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We calculate the structure of an effectively optically thin and geometrically thin accretion disk in the Kerr geometry, including electron-positron pairs. We show that the properties of the disk solutions are strongly dependent on the angular momentum of the central black hole. We find that close to a rapidly rotating hole there can be an appreciable pair density even for modest accretion rates. Pair critical accretion rates recently discovered in Newtonian disk models are also shown to be present in the general relativistic models, and we show that the geometrically thin disk approximations easily break down for rapidly rotating holes.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 765-769
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    Relativistic hadrons and the origin of relativistic outflows in active galactic nuclei (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We examine the hydrodynamic origin of relativistic outflows in active galactic nuclei (AGN). Specifically, we propose that the presence of a population of relativistic hadrons in the AGN 'central engine' and the associated neutron production suffices to produce outflows which under rather general conditions could be relativistic. The main such condition is that the size of the neutron production region be larger than the neutron flight path tau(sub n) approximately 3 x 10(exp 13) cm. This condition guarantees that the mean energy per particle in the proton fluid, resulting from the decay of the neutrons outside their production region, be greater than the proton rest mass. The expansion of this fluid can then lead naturally to a relativistic outflow by conversion of its internal energy to directed motion. We follow the development of such flows by solving the mass, energy as well as the kinetic equation for the proton gas in steady state, taking into account the source terms due to compute accurately the adiabatic index of the expanding gas, and in conjunction with Bernoulli's equation the detailed evolution of the bulk Lorentz factor. We further examine the role of large-scale magnetic fields in confining these outflows to produce the jets observed at larger scales.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 521-532
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    Flow downstream of the heliospheric terminal shock: Magnetic field line topology and solar cycle imprint (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The topology of the magnetic field in the heliosheath is illustrated using plots of the field lines. It is shown that the Archimedean spiral inside the terminal shock is rotated back in the heliosheath into nested spirals that are advected in the direction of the interstellar wind. The 22-year solar magnetic cycle is imprinted onto these field lines in the form of unipolar magnetic envelopes surrounded by volumes of strongly mixed polarity. Each envelope is defined by the changing tilt of the heliospheric current sheet, which is in turn defined by the boundary of unipolar high-latitude regions on the Sun that shrink to the pole at solar maximum and expand to the equator at solar minimum. The detailed shape of the envelopes is regulated by the solar wind velocity structure in the heliosheath.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3463-3471
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    Balloon-borne measurements of the SN 1987A hard X-ray continuum (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: SN 1987A hard X-ray continuum spectra obtained on 1987 October 29, 1988 April 9-10, and 1988 November 11 from balloon-flight measurments are presented. The spectra, spanning the energy range from 25 keV to 300 keV, have been analyzed using a detector response matrix inversion technique that converts the spectra form counts/s/sq cm keV to photons/s/sq cm keV allowing direct comparison with theoretical models. The results indicate that the bulk of the (56)Co is mixed moderately through the inner regions of the supernova envelope but they do not preclude the mixing of a small amount of the (56)Co farther out into the envelope necessary to account for the observed (56)Co line fluxes. The effect of the ratio (57)Co to (56)Co on the 1988 November 11 continuum spectrum is discussed.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 963-975
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    The ultraviolet spectrum of the gravitational lens candidate UM 425 = QSO 1120+019: Evidence for broad absorption line (BAL) structure (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The UV line profile structure of high-ionization resonance lines found with the International Ultraviolet Explorer (IUE) in the brightest of four multiply imaged sources (images-A) in the candidate gravitational lens UM 425 = QSO 1120+019 indicates broad absorption line (BAL) structure. The deep-broad trough associated with the O IV line extends to velocities approiximately -12,000 km/s, and contains disrete features that suggest multicomponent velocity structure. This structure may include contributions from C IV absorption from the early-type galaxy that is believed to lens UM 425. A strong absorption feature in the blue wing of the Lyman-alpha lambda 1216 emission line may be a Lyman alpha absorption system at a Z(sub Ly alpha) = 1.437 +/- 0.003, or it may be formed by the superposition of the broad N V lambda lambda 1238, 1242 absorption trough on the extended blue emission wing of the QSO Lyman-alpha line. We obtained a redshift of Z(sub QSO) = 1.471 +/- 0.003 from Lyman-alpha lambda 1215, consistent with the redshift found by Meylan and Djorgovski in the optical. The Lyman-alpha line appears unusally weak due to the presence of N V lambda 1240 BAL absorption. A Lyman-limit absorption system at lambda 912 was not observed in the QSO rest frame. The detection of BAL structure in the other weaker ground-state resonance lines of N II (l) and S IV (l) was not found, suggesting these lines are formed in a region that is distinct from the BAL component. Detection of BAL structure in the other fainter images in this system with Hubble Space Telescope (HST) instrumentation, similar to structure observed here in image A, could provide evidence that UM 425 is a gravitational lens.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 599-603
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    Heating and ionization of stellar chromospheres by nonthermal proton beams: Implications for impulsive phase, redshifted Lyman-alpha radiation in stellar flares (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We investigate the physical basis for the timescale of impulsive-phase, redshifted Lyman-alpha emission in stellar flares on the assumption that it is determined by energy losses in a nonthermal proton beam that is penetrating the chromosphere from above. The temporal evolution of ionization and heating in representative model chromospheres subjected to such beams is calculated. The treatment of 'stopping' of beam protons takes into account their interactions with (1) electrons bound in neutral hydrogen, (2) nuclei of neutral hydrogen, (3) free electrons, and (4) ambient thermal protons. We find that, for constant incident beam flux, the system attains an equilibrium with the beam energy input to the chromosphere balanced by radiative losses. In equilibrium, the beam penetration depth is constant, and erosion of the chromosphere ceases. If the redshifted, impulsive-phase stellar flare Lyman-alpha emission is produced by downstreaming hydrogen formed through charge exchange between beam protons and ambient hydrogen, then the emission should end when the beam no longer reaches neutral hydrogen. The durations of representative emission events calculated on this assumption range from 0.1 to 14 s. The stronger the beam, the shorter the timescale over which the redshifted Lyman-alpha emission can be observed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 1; p. 385-399
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    Ultraluminous infrared galaxies and the radio-optical correlation for quasars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Through analysis of available optical spectrophotometric data and radio flux density measurements in the literature, it is demonstrated that a good correlation exists between the radio power and bolometric luminosity of the optically-selected OSOs in the Bright Quasar Sample (BOS) of Schmidt and Green (1983). We have recently used VLBI measurements of a sample of ultraluminous infrared galaxies to infer the likely existence of radio-quiet Active Galactic Nuclei (AGNs) deeply enshrouded in dust within their nuclei (Lonsdale, Smith, and Lonsdale 1993). We employ the radio-bolometric luminosity correlation for the BQS quasars to test whether these hypothetical buried AGNs can be energetically responsible for the observed far-infrared luminosities of the ultraluminous infrared galaxies. The ultraluminous infrared galaxies are shown to follow the same relation between radio core power and bolometric luminosity as the radio-quiet QSOs, suggesting that buried AGNs can account for essentially all the observed infrared luminosity, and raising the possibility that any starburst which may be in progress may not be energetically dominant. The broader implications of the radio-optical correlation in quasars for AGNs and luminous infrared galaxy models and the use of radio astronomy as a probe of the central powerhouse in radio quiet AGNs and luminous infrared galaxies are briefly discussed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 2; p. 623-642
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    A Fizeau optical interferometer astrometric satellite (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The proposed design and construction of the Fizeau astrometric mapping explorer (FAME), a small astrometric instrument for use on an artificial satellite, is reported on. The instrument and spacecraft are designed to slowly spin and will repeatedly scan great circles on the sky so that, over a period of time, it will cover the complete sky and repeat in a manner similar to that of the Hipparcos satellite. The instrument will use the two fixed dilute aperture telescopes to measure a fixed angle between stars and detect the positions, magnitude and color of all stars crossing its field of view to a visual magnitude of approximately 15 mag. The aim of the instrument is to obtain a catalog of positions, proper motions and parallaxes of all stars down to about 15 mag, with a magnitude dependent accuracy of positions of 20 to 800 micro arcsec, proper motions of 20 to 800 micro arcsec per year and parallaxes of 20 to 800 micro arcsec.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 187-189
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    Analysis of an astrometric Fizeau interferometer for GAIA (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The concepts related to the operation and design of the global astrometric interferometer for astrophysics (GAIA) bring together solutions chosen for the astrometry satellite and interferometric techniques. Like the Hipparcos satellite, GAIA is a continuously scanning instrument for which the integration time on any observed object is limited by the field of view of the detector. If a final astrometric accuracy of 10 microarcsec is aimed at, a field of 1 deg in diameter is needed. A design is presented for the proposed 2.6 m baseline Fizeau interferometer with two 40 cm apertures and overall dimensions compatible with the size of the Ariane 5 payload shroud. It has a 0.9 deg diffraction limited field of view. The response of the optical system to small perturbations on each optical element is given in terms of the fringe visibility, which is shown to be dependent on the sub-aperture spot separation. The robustness of the design to thermal, mechanical and manufacturing errors is discussed. The unavoidable distortion present in wide field optical systems is analyzed in terms of displacement of the interference fringes.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 241-249
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    Linking GAIA proper motions to the extragalactic reference system by QSO observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A direct link to an extragalactic reference system is considered as being a principle aim of the global astrometric interferometer for astrophysics (GAIA) mission. The data available from an extragalactic data base and a quasi stellar object (QSO) catalog were used to obtain an estimation of the number of QSO link candidates. The quality of presently available data and the expected accuracy of the extragalactic link are discussed. It is concluded that at least 150 QSO's must be observed by GAIA in order to guarantee an accuracy of better than 1 microarcsec/year for the link. New observations will be needed before the GAIA launch in order to reduce uncertainties in the positions, magnitudes and redshifts for some known quasars. The variability of QSO's with magnitudes near the GAIA observation limit can raise a potential problem. The motions of nearby QSO's are expected to be much smaller than 2 microarcsec/year, and therefore, will not affect the accuracy of the link in the proposed GAIA mission.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 127-129
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    Observations of ice-sheet motion in Greenland using satellite radar interferometry (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present interferometric observations of ice-sheet motion in western Greenland based on pairs of ERS-1 synthetic aperture radar (SAR) images. These observations provide the first detailed regional view of ice motion associated with dynamically supported topography near the margin of an ice sheet. The interferograms of this area are much more complicated than other interferograms of ice sheets presented to date. We devote the largest part of this paper to explaining the source of the complexity in these interferograms. A synthetic interferogram based on a simple model helps to illustrate the effects of different components of the ice velocity field in interferometric data and suggests a method for estimating the large-scale ice velocity field from such data.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 5; p. 571-574
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    Transition probabilities for the UV0.01 multiplet in N III (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report on large-scale ab initio multiconfiguration Hartree-Fock calculations for the UV0.01 multiplet, 2s(sup 2)2p(sup 2)P(sub J) - 2s2p(sup 2 4)P(sub J prime), in N III. The resulting transition probabilities agree very well with recent semiempirical calculations, and the lifetimes for two of the three upper levels agree with experiments. The deviation for the third level is discussed. Comparisons made with the highest quality IUE echelle spectra available -- those of RR Tel and V1016 Cyg (both photoionized sources with electron densities below 10(exp 8)/cu cm) -- show that computed branching ratios of lines sharing a common upper level are in agreement with observations to within uncertainties of +/- 10%. High-quality solar limb data or stellar data from the Hubble Space Telescope (HST) could, in principle, be used to determine whether the theoretical or measured lifetimes for the discrepant level are in error. Unfortunately, stellar data for high-density plasmas (N(sub e) greater than 10(exp 11)/cu cm are needed) do not yet exist, and existing solar data lack the photometric precision to address this problem.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 1; p. 457-464
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    Asteroid orbit evolution due to thermal drag (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Thermal drag, a variant of the Yarkovsky effect, may act on small asteroids with sizes from a few meters to a few tens of meters. Yarkovsky thermal drag comes from an asteroid's absorbing sunlight in the visible and reradiating it in the infrared. Since the infrared photons have momentum, by action-reaction, they kick the asteroid when they leave its surface. The reradiation, which is asymmetric in latitude over the asteroid, gives a net force along the asteroid's pole. Due to the asteroid's thermal inertia, averaging this force over one orbital period produces a net drag if the spin axis has a component in the orbital plane. Thermal drag tends to circularize orbits. It can increase or decrease orbital inclinations. An object whose spin axis points in random directions over its lifetime displays little change in orbital inclination. Thermal drag appears to have little to do with the delivery of chondrites from the asteroid belt; the thermal drag timescale (10(exp 8) years for meter-sizzed objects) is long compared with their cosmic ray exposure ages, and aphelia in the asteroid belt are not expected for mature thermal drag orbits. However, Yarkovsky thermal drag may act on the recently discovered near-Earth asteroids, which have radii of 10-30 m. Asteroid 1992 DA, for instance, might have its orbit shrunk by 0.1 AU in 3 x 10(exp 7) years, removing it from an Earth-crossing orbit. The near-Earth asteroids also tend to have small to moderate orbital eccentricities, as expected for highly evolved thermal drag objects. However, the time needed to bring them in from the asteroid belt (about 10(exp 9) years) is long compared with the collisonal and dynamical lifetimes (both about 10(exp 8) years) for Earth-crossing objects, arguing against their emplacement by thermal drag.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E1; p. 1585-1594
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    Simulated cosmic microwave background maps at 0.5 deg resolution: Unresolved features (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: High-contrast peaks in the cosmic microwave background (CMB) anisotropy can appear as unresolved sources to observers. We fit simluated CMB maps generated with a cold dark matter model to a set of unresolved features at instrumental resolution 0.5 deg-1.5 deg to derive the integral number density per steradian n (greater than absolute value of T) of features brighter than threshold temperature absolute value of T and compare the results to recent experiments. A typical medium-scale experiment observing 0.001 sr at 0.5 deg resolution would expect to observe one feature brighter than 85 micro-K after convolution with the beam profile, with less than 5% probability to observe a source brighter than 150 micro-K. Increasing the power-law index of primordial density perturbations n from 1 to 1.5 raises these temperature limits absolute value of T by a factor of 2. The MSAM features are in agreement with standard cold dark matter models and are not necessarily evidence for processes beyond the standard model.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 441; 1; p. L5-L7
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    Simulated cosmic microwave background maps at 0.5 deg resolution: Basic results (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have simulated full-sky maps of the cosmic microwave background (CMB) anisotropy expected from cold dark matter (CDM) models at 0.5 deg and 1.0 deg angular resolution. Statistical properties of the maps are presented as a function of sky coverage, angular resolution, and instrument noise, and the implications of these results for observability of the Doppler peak are discussed. The rms fluctuations in a map are not a particularly robust probe of the existence of a Doppler peak; however, a full correlation analysis can provide reasonable sensitivity. We find that sensitivity to the Doppler peak depends primarily on the fraction of sky covered, and only secondarily on the angular resolution and noise level. Color plates of the simulated maps are presented to illustrate the anisotropies.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 441; 1; p. L1-L4
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    Photon-splitting limits to the hardness of emission in strongly magnetized soft gamma repeaters (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Soft gamma repeaters are characterized by recurrent activity consisting of short-duration outbursts of high-energy emission that is typically of temperature less than 40 keV. One recent model of repeaters is that they originate in the environs of neutron stars with superstrong magnetic fields, perhaps greater than 10(exp 14) G. In such fields, the exotic process of magnetic photon splitting gamma yields gamma gamma acts very effectively to reprocess gamma-ray radiation down to hard X-ray energies. In this Letter, the action of photon splitting is considered in some detail, via the solution of photon kinetic equations, determining how it limits the hardness of emission in strongly magnetized repeaters, and thereby obtaining observational constraints to the field in SGR 1806-20.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 440; 2; p. L69-L72
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    Understanding COMPTEL Al-26 1.8 MeV map features (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The COMPTEL sky map of the 1.8 MeV line emission from Al-26 shows an extended diffuse distribution along the Galactic plane with a peculiar large scale asymmetry about the Galactic center (GC) and a clumpy structure with several noticeable hot spots. The most prominent hot spot at the GC appears shifted to positive longitude by about 2 deg. Nearby supernova remnants or Wolf-Rayet stars are plausible explanations for individual hot spots such as in the Vela region. We show that the global asymmetry and most hot spots can be understood by a more general model: the Al-26 sources are confined in the spiral arms of our Galaxy, and coagent star formation is responsible for additional clumpiness. The off-centered GC hot spot is probably due to the observed asymmetrically distributed circumnuclear molecular gas interacting with a central stellar bar, whose existence has been inferred from IR observations.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 440; 2; p. L57-L60
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    Computer processed LANDSAT data (1982)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: Background information and exercises are provided to: (1) establish or expand understanding of the concepts, methods, and terminology of computer processing of image producing data; (2) develop insight into the advantages of computer based image processing compared with the photointerpretation approach for processing, classifying, interpreting, and applying remote sensing data; (3) foster a broad perspective on the principal of the main techniques for image enhancement, pattern recognition, and thematic classification; (4) appreciate the pros and cons of batch and interactive modes of image analysis; (5) examine and evaluate some specific computer generated products for subscenes in Pennsylvania and New Jersey; and (6) interrelate these particular examples of output with more theoretical explanations of computer processing strategies and procedures.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 145-232
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    Radar-visible wind streaks in the Altiplano of Bolivia (1984)
    In:  CASI
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    Publication Date: 2006-04-06
    Description: Isolated knobs that are erosional remnants of central volcanoes or of folded rocks occur in several areas of the Altiplano are visible on both optical and images. The optically visible streaks occur in the immediate lee of the knobs, whereas the radar visible streaks occur in the zone downwind between the knobs. Aerial reconnaissance and field studies showed that the optically visible streaks consist of a series of small ( 100 m wide) barchan and barchanoid dunes, intradune sand sheets, and sand hummocks (large shrub coppice dunes) up to 15 m across and 5 m high. On LANDSAT images these features are poorly resolved but combine to form a bright streak. On the radar image, this area also appears brighter than the zone of the radar dark streak; evidently, the dunes and hummocks serve as radar reflectors. The radar dark streak consists of a relatively flat, smooth sand sheet which lacks organized aerolian bedforms, other than occasional ripples. Wind velocity profiles show a greater U value in the optically bright streak zone than in the radar dark streak.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 271-272
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    The erosion of streamlined islands, longitudinal grooves and scour marks: Implications to the origin of the Martian outflow channels (1984)
    In:  CASI
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    Publication Date: 2006-04-06
    Description: The diversity of proposed origins for large Martian outflow channels results from the differing interpretations given to the landforms associated with the outflow channels. In an attempt to help limit the possible mechanisms of channel erosion, detailed studies of three of the channel features were done; the streamlined islands, longitudinal grooves and scour marks. This examination involved a comparison of the martian streamlined islands with various streamlined landforms on Earth including those found in the Channel Scabland in large rivers, glacial drumlins, and desert yardangs. The comparisons included statistical analyses of the landform lengths versus widths and positions of maximum width, and an examination of the degree of shape agreement with the geometric lemniscate which was in turn demonstrated to correspond closely with true airfoil shapes. The analyses showed that the shapes of the martian islands correspond closely to the streamlined islands in rivers and the Channel Scabland land. Drumlins show a much smaller correlation. Erosional rock islands formed by glaciers are very much different in shape.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 200-202
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    Space debris impact experiment (S0001) (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The specific objectives of this experiment are to establish the population and size distribution of meteoroids in the mass range from 10 to the minus 10 power to 10 to the minus 4 power G, to establish the current population of man-made debris in the same mass range, and to obtain data on the physical properties (composition and density) of meteoroids.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 136-137
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    Interplanetary dust experiment (A0201) (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The objective of this experiment is to study interplanetary dust, variously referred to as cosmic dust, cometary dust, zodiacial dust, or meteoric dust particles. Specific objectives are to obtain information regarding particle mass and velocity, and to undertake correlative analyses with other experiments, both on LDEF or near the time of the LDEF flight.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 134-135
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    Attempt at dust debris collection with stacked detectors (A0138-2) (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The primary objective of this experiment is to investigate the feasibility of future missions of multilayer thin-film detectors acting as energy sorter to collect micrometeoroids, if not in their original shape, at least as fragments suitable for chemical analysis. It is expected that this kind of particle collector will help in solving one of the most puzzling topics in cosmic-dust studies: the mineralogical and chemical composition of the particles. This is a matter of great interest in the study of the origin and evolution of the solar system.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 124-126
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    Appendix C. LANDSAT: A worldwide perspective (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Images characteristics of geographic regions other than the northeastern part of the United States are presented for interpretation. Pre- and post-eruption imagery of Mt. St. Helens volcano serves to demonstrate the advantages of thermal infrared sensing, and the potential for developing a timely, decision oriented thematic map to be used in solving drought-related problems in Upper Volta is examined to show the applicability of satellite remote sensing in all geographic areas.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 455-475
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    Impact of Mount St. Helens eruption on hydrology and water quality (1982)
    In:  CASI
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    Publication Date: 2006-04-12
    Description: The 1980 eruptions of Mount St. Helens in southeast Washington resulted in a pronounced effect on the surface and ground water resources of the state. In response to the volcanic activity, the U.S. Geological Survey intensified statewide surface and ground water sampling programs to determine the nature and magnitude of the volcanic-induced variations. Streams to the east of Mount St. Helens received the major ash fallout. Chemical effects were best noted in smaller streams sampled 60 to 70 miles northeast of Mount St. Helens. The chemical variations observed were pronounced but short lived. Sulfate and chloride increases in anionic composition were prevalent immediately following the eruption; however, the original bicarbonate predominance was again attained within several days. Suspended iron and aluminum concentrations were similarly elevated during the period of greatest ash deposition (highest turbidity); however, the dissolved concentrations remained relatively constant. Depressions of pH were minor and short lived. Streams draining to the south, tributaries to the Columbia river, showed little observable changes in water chemistry. Streams draining to the west (Toutle river and its tributaries) were compositionally affected by the various volcanic activities. Chloride and sulfate anion percentage exceeded the bicarbonate percentage up to one month following the eruption period. Streams and lakes sampled in the immediate vicinity of Mount St. Helens, in addition to trace metals, contained organic compounds derived from decomposing wood buried in the debris deposits. This organic material may constitute a significant source of organic compounds to surface and ground water for some time to come.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Langley Research Center Atmospheric Effects and Potential Climatic Impact of the 1980 Eruptions of Mt. St. Helens; p 43-46
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    Some closing thoughts: Practical payoffs from satellite systems (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: The benefits-to-cost ratio of satellite remote sensing, both as a substitute for conventional methods of monitoring and assessing resources, and as a supplement to these methods is examined using a model which analyzes the cost of aerial photography versus satellite scanner for producing and interpreting an image of the Earth's surface sized to LANDSAT dimensions. Examples of cost savings are tabulated for ground surveys, aerial photos, and LANDSAT. Possible additional benefits from LANDSAT D are assessed. The way in which satellites fit into more comprehensive models for resources management is discussed. It is shown that remote sensing is but one essential component in a complex system that aggregates technical. Socioeconomics, political, cultural, and other factors in the human decision process.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 389-407
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    Appendix B: Principles of computer processing of LANDSAT data (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Computer processing facilitates extraction of information from every pixel by executing a variety of functional operations, called processed algorithms, in general or specialized routines. The best results are obtained when data from more than one multispectral band are used together. Multivariate tatistical analysis, computer tape characteristics, processing modes, and a choice of systems (batch or interactive) are discussed. The major operations in computer processing elaborated include: preprocessing, enhancement, effects of rationing, and classification. Techniques for multisource data correlation are considered with emphasis on geobased systems.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 421-453
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    Near surface observations (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Learning objectives include: (1) developing an understanding of the implications of the term "near surface observations"; (2) associating the appearance of large ground features as seen in satellite imagery with their appearance as seen from the ground; (3) grasping criteria and procedures for selecting training sites on the ground for use in supervised classification; (4) running through an example of training site selection; (5) becoming familiar with several methods of accuracy assessment; (6) becoming aware of the approach and value of making supporting measurements of the spectral and physical properties of materials on the ground and from aircraft; (7) taking note of the different types of instruments used in making specific ground measurements; and (8) appreciating the rationale underlying laboratory and field studies on or near the Earth's surface for the purpose of developing new sensor systems.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 233-276
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    Photointerpretation of LANDSAT images (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Learning objectives include: (1) developing a facility for applying conventional techniques of photointerpretation to small scale (satellite) imager; (2) promoting the ability to locate, identify, and interpret small natural and man made surface features in a LANDSAT image; (3) using supporting imagery, such as aerial and space photography, to conduct specific applications analyses; (4) learning to apply change detection techniques to recognize and explain transient and temporal events in individual or seasonal imagery; (5) producing photointerpretation maps that define major surface units, themes, or classes; (6) classifying or analyzing a scene for specific discipline applications in geology, agriculture, forestry, hyrology, coastal wetlands, and environmental pollution; and (7) evaluating both advantages and shortcomings in relying on the photointerpretive approach (rather than computer based analytical approach) for extracting information from LANDSAT data.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 101-143
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    Some spectral and spatial characteristics of LANDSAT data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-16
    Description: Activities are provided for: (1) developing insight into the way in which the LANDSAT MSS produces multispectral data; (2) promoting understanding of what a "pixel" means in a LANDSAT image and the implications of the term "mixed pixel"; (3) explaining the concept of spectral signatures; (4) deriving a simple signature for a class or feature by analysis: of the four band images; (5) understanding the production of false color composites; (6) appreciating the use of color additive techniques; (7) preparing Diazo images; and (8) making quick visual identifications of major land cover types by their characteristic gray tones or colors in LANDSAT images.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 81-99
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  • 79
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    Familiarization with LANDSAT imagery (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Learning objectives of the activities provided include: (1) reading the annotation of a LANDSAT image; (2) becoming acquainted with the characteristics of 1:1,000,000 scale transparencies and prints of MSS images; (3) noting the general information visible in LANDSAT photo products; (4) observing changes of appearance of any ground feature or class in the black and white images made from the four MSS bands and the characteristic color of each class in color composites; (5) determining the degree to which a LANDSAT image meets map accuracy standards and can be fitted to map projections; (6) assessing the effects of LANDSAT enlargements and scale changes and of the limitations of satellite resolution relative to aerial photos; (7) observing the influence of time of acquisition (season) on a scene; (8) getting a feel for image quality as dependent on processing and photoreproduction; (9) appreciating the characteristics of the RBV and thermal band imagery obtained from LANDSAT-3; and (10) becoming familiar with certain attributes of adjacent LANDSAT images which permit them to be joined in mosaics and to be viewed in stereo.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 39-80
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  • 80
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    Appendix A: The LANDSAT system (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: The primary LANDSAT mission and the system requirements are summarized and pertinent parameters of the spacecraft, its orbit, and payload are tabulated. The history acquisition to entry into the archives for storage and product generation and dissemination is recounted. The LANDSAT D data handling plan is discussed showing requirements for both the MSS CCT and the thematic mapper CCT.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 409-419
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  • 81
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    Some fundamental concepts in remote sensing (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: The term remote sensing is defined as well as ideas such as class, pattern, feature, pattern recognition, feature extraction, and theme. The electromagnetic spectrum is examined especially those wavelength regions available to remote sensing. Relevant energy and wave propagation laws are discussed and the characteristics of emitted and reflected radiation and their detection are investigated. The identification of classes by their spectral signatures, the multispectral approach, and the principal types of sensors and platforms used in remote sensing are also considered.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 9-38
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  • 82
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    Microwave remote sensing experiment (1981)
    In:  CASI
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    Publication Date: 2006-06-04
    Description: Operation of the microwave instrument as a two frequency scatterometer, a synthetic aperture radar, and a passive microwave radiometer is planned. Operation of the instrument in each of its three modes is discussed and the antenna system described.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 3 p
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  • 83
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    Kinetic theory in astrophysics and cosmology (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Results associated with exact solution of the Einstein-Boltzmann and Einstein-Maxwell-Boltzmann equations are presented. The generalization of Ehler's killing vector approach for the distribution function to charged particles is considered.
    Keywords: ASTROPHYSICS
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 21 p
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  • 84
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    Multiprocess evolution of landforms in the Kharga Region, Egypt: Applications to Mars (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: In order to understand better the polygenetic evolution of landforms on the martian surface, field studies were conducted in and around the Kharga Depression, Egypt. The Kharga region, on the eastern edge of Egypt's Western Desert, was subject to erosion under mostly hyperarid climatic conditions, punctuated by brief pluvial episodes of lesser aridity, since early Pleistocene time. The region contains numerous landforms analogous to features on the martian surface: yardangs carved in layered surficial deposits and in bedrock, invasive dune trains, wind-modified channels and interfluves, and depressions bounded by steep scarps. Like many of the topographic depresions on Mars, the Kharga Depression was invaded by crescentic dunes. In Egypt, stratigraphic relations between dunes, yardangs, mass-wasting debris, and wind-eroded flash-flood deposits record shifts in the relative effectiveness of wind, water, and mass-wasting processes as a function of climate change.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 225-227
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  • 85
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    A comparison of stratified versus regression estimators (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: LANDSAT data acquired over an agricultural area along with ground enumeration of the same area are used to obtain crop acreage estimates which are better (as measured in terms of bias and variance) than can be obtained from either data source alone. Two basic approaches considered within the AgRISTARS program are a stratified crop acreage estimator and a regression estimator. A statement of the problem was mathematically formulated and some theorems were proved which relate to the variance of the two estimators. For a particular set of data, the regression and stratified estimators are compared in terms of certain easily computed parameters.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Houston Univ. The 1981 NASA ASEE Summer Fac. Fellowship Program, Vol. 2; 17 p
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  • 86
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    Experiments examining the shapes of isolated bars in comparison with those occurring in braided rivers (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Sand bars and islands within braided rivers have characteristic rhomboid or diamond shapes, often becoming very complex in form as the density of islands increases. Similar forms are observed in the martian outflow channels where the islands occur in groups. This contrasts with the more isolated martian islands which have airfoil shapes, as do isolated streamlined islands in rivers and in the Channeled Scabland. These observations indicate that the bar and island forms are controlled by the density of the islands, with increasing island interaction and flow modification as the density increases. As a continuation of previous flume experiments on the shapes of isolated islands, a new series of experiments investigate the modifications produced by a progressive increase in island density, finally leading to a true braided system.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 198-199
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  • 87
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    Interstellar-gas experiment (A0038) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The objectives of this experiment are to collect and isotopically analyze interstellar gas atoms around the orbit of the Earth for the purpose of obtaining new data relevant to understanding nucleosynthesis, and to study the dynamics of the interstellar wind inside the heliosphere and the isotopic composition of the interstellar medium outside the heliosphere. The experiment hardware will act as a set of simple cameras with high-purity copper-beryllium collecting foils serving as the film. The experiment housing will mount and thermally control the foils, establish the viewing angles and viewing direction, provide baffling to reject ambient neutral particles, provide a voltage grid to reject ionospheric charged particles, sequence collecting foils, control exposure times, and protect the foils from contamination during the deployment and retrieval of the LDEF. After being returned to Earth, the entrapped atoms can be analyzed by mass spectroscopy to determine the relative abundance of the different isotopes of helium and neon. An attempt will also be made to detect argon.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 98-100
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  • 88
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    Other remote sensing systems: Retrospect and outlook (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-16
    Description: The history of remote sensing is reviewed and the scope and versatility of the several remote sensing systems already in orbit are discussed, especially those with sensors operating in other EM spectral modes. The multisensor approach is examined by interrelating LANDSAT observations with data from other satellite systems. The basic principles and practices underlying the use of thermal infrared and radar sensors are explored and the types of observations and interpretations emanating from the Nimbus, Heat Capacity Mapping Mission, and SEASAT programs are examined. Approved or proposed Earth resources oriented missions for the 1980's previewed include LANDSAT D, Stereosat, Gravsat, the French satellite SPOT-1, and multimission modular spacecraft launched from space shuttle. The pushbroom imager, the linear array pushbroom radiometer, the multispectral linear array, and the operational LANDSAT observing system, to be designed the LANDSAT-E series are also envisioned for this decade.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 327-387
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  • 89
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    A case study in the practical use of LANDSAT data (1982)
    In:  CASI
    Details
    Publication Date: 2006-04-16
    Description: The use of computer aided classification of LANDSAT data in developing water quality plans for New Jersey watersheds is used to exemplify how a state natural resource management program benefits from satellite imagery. The transition of a research and development system into an operational remote sensing system to help decision makers is demonstrated. Nontechnial issues that can assist (or hinder) an agency in adopting a new technology are examined. The progress of LANDSAT use by state government from the earliest stage of curiosity through to incorporation in actual state planning methods is charted. Potential applications of LANDSAT data to real information needs and solutions to management problems are examined. The problems and mistakes that occurred in using LANDSAT data in the past are discussed as well as the ways by which these problems were overcome.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 309-326
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  • 90
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    Geographic information systems (1982)
    In:  CASI
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    Publication Date: 2006-04-16
    Description: Information and activities are provided to: (1) enhance the ability to distinguish between a Geographic Information System (GIS) and a data management system; (2) develop understanding of spatial data handling by conventional methods versus the automated approach; (3) promote awareness of GIS design and capabilities; (4) foster understanding of the concepts and problems of data base development and management; (5) facilitate recognition of how a computerized GIS can model conditions in the present "real world" to project conditions in the future; and (6) appreciate the utility of integrating LANDSAT and other remotely sensed data into the GIS.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 277-308
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  • 91
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    Automated spectral classification and the GAIA project (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Two dimensional spectral types for each of the stars observed in the global astrometric interferometer for astrophysics (GAIA) mission would provide additional information for the galactic structure and stellar evolution studies, as well as helping in the identification of unusual objects and populations. The classification of the large quantity generated spectra requires that automated techniques are implemented. Approaches for the automatic classification are reviewed, and a metric-distance method is discussed. In tests, the metric-distance method produced spectral types with mean errors comparable to those of human classifiers working at similar resolution. Data and equipment requirements for an automated classification survey, are discussed. A program of auxiliary observations is proposed to yield spectral types and radial velocities for the GAIA-observed stars.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 169-172
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  • 92
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    Interstellar grains in elliptical galaxies (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We consider the evolution and heating of dust embedded in the hot interstellar medium of isolated elliptical galaxies. We first construct a new set of galaxy models spanning a decade in luminosity which we use to study the evolution of dust as it is ejected by stellar sources, merges and flows with the interstellar gas, and is sputtered away due to the presence of the hot gas. We find that although grains can flow a considerable distance from the parent star in some cases before being sputtering away, the grain size distribution at a given location is accurately determined by assuming in situ sputtering of dust grains as they are ejected by the parent star. We find that dust heating is dominated by absorption of ambient starlight. Heating due to collisions with energetic electrons in the hot gas and absorption of thermal X-rays is smaller by orders of magnitude. We also find that for the largest galaxy considered (L(sub B) approximately 10 (exp 11) solar luminosity) the energy lost from the hot gas due to electronic collisions with the dust is about an order of magnitude less than that lost due to thermal emission in X-rays. The gas in smaller galaxies loses even less of its energy via heating of grains. In deriving this result, we find that the inclusion of grain sputtering is a crucial ingredient of the calculation. The presence of dust grains is therefore energetically unimportant for elliptical galaxy cooling flow models.
    Keywords: ASTROPHYSICS
    Type: Astronomical Society of the Pacific, Airborne Astronomy Symposium on the Galactic Ecosystem: From Gas to Stars to Dust, Volume 73; p 177-180
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  • 93
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    Morphology, near-infrared luminosity, and mass of the Galactic bulge from COBE DIRBE observations (1995)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Near-infrared images of the Galactic bulge at 1.25, 2.2, 3.5, and 4.9 microns obtained by the Diffuse Infrared Background Experiment (DIRBE) onboard the Cosmic Background Explorer (COBE) satellite are used to characterize its morphology and to determine its infrared luminosity and mass. Earlier analysis of the DIRBE observations (Weiland et al. 1994) provided supporting evidence for the claim made by Blitz & Spergel (1991) that the bulge is bar-shaped with its near end in the first Galactic quadrant. Adopting various triaxial analytical functions to represent the volume emissivity of the source, we confirm the barlike nature of the bulge and show that triaxial Gaussian-type functions provide a better fit to the data than other classes of functions, including an axisymmetric spheroid. The introduction of a `boxy' geometry, such as the one used by Kent, Dame, & Fazio (1991) improves the fit to the data. Our results show that the bar is rotated in the plane with its near side in the first Galactic quadrant creating an angle of 20 deg +/- 10 deg between its major axis and the line of sight to the Galactic center. Typical axis ratios of the bar are (1:0.33 +/- 0.11:0.23 +/- 0.08), resembling the geometry of prolate spheroids. There is no statistically significant evidence for an out-of-plane tilt of the bar at 2.2 microns, and marginal evidence for a tilt of approximately equal 2 deg at 4.9 microns. The introduction of a roll around the intrinsic major axis of the bulge improves the `boxy' appearance of some functions. A simple integration of the observed projected intensity of the bulge gives a bulge luminosity of 1.2 x 10(exp 9), 4.1 x 10(exp 8), 2.3 x 10(exp 8), and 4.3 x 10(exp 7) solar luminosity, respectively, at 1.25, 2.2, 3.5, and 4.9 microns wavelength for a Galactocentric distance of 8.5 kpc. The 2.2 microns luminosity function of the bulge population in the direction of Baade's window yields a bolometric luminosity of L(sub bol) = 5.3 x 10(exp 9) solar luminosity. Stellar evolutionary models relate this luminosity to the number of main-sequence progenitor stars that currently populate the red giant branch. Combined with the recent determination of the main-sequence turnoff mass for the bulge by the Hubble Space Telescope (Holtzman et al. 1993) we derive a photometrically determined bulge mass of approximately equal to 1.3 x 10(exp 10) solar mass for a Salpeter initial mass function extended down to 0.1 solar mass.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 716-730
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  • 94
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    ASCA and ROSAT observations of NRAO 140 and IX Persei (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report the results from observations of National Radio Astronomy Observatory (NRAO) 140 carried out in the X-ray band using ROSAT and Advanced Satellite for Cosmology and Astrophysics (ASCA) in 1992 and 1994. We find the source to be absorbed by an effective hydrogen column density of approximately 3 x 10(exp 21) atoms/sq cm during both epochs, consistent with the combined atomic and molecular column inferred from radio measurements along this line of sight through the Perseus cloud complex. We compare these results with previous X-ray absorption measurements and briefly comment upon the origin of the excess absorption which has been seen toward this source. We find the ASCA spectrum of NRAO 140 is well described by a power law of energy index alpha = 0.73 +/- 0.03 and also yields the tightest constraint to date on Fe K-shell emission, with 90% confidence upper limits of 38 and 31 eV for a narrow line at a rest frame energy of 6.4 and 6.7 keV respectively. This, along with a lack of hardening towards higher energies, suggests that either NRAO 140 is devoid of cold reprocessing material, the reprocessing material has a geometry in which the imprinted features are weak, and/or the X-ray emission is relativistically beamed towards us. We also report the detection of a serendipitous source in both the Advanced Satellite for Cosmology and Astrophysics Gas Imaging Spectrometer (ASCA GIS) and ROSAT fields of view. We identify this source as the binary star system IX Per and find its spectrum to be well fitted by a two-temperature Raymond-Smith plasma.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 660-665
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  • 95
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    The spatial variation of the infrared-to-radio ratio in spiral galaxies (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have produced two-dimensional maps of the intensity ratio, Q(sub 60), of 60 micron infrared to 20 cm radio continuum emission, for a set of 25 nearby galaxies, mostly spirals. The ratio maps were obtained from infrared images made using IRAS data with the maximum correlation method, and radio images made using VLA data. Before taking the ratio, the radio images were processed so as to have the same resolution properties as the infrared images; the final spatial resolution in all cases is approximately 1 min, corresponding to 1 - 2 kpc for most galaxies. This resolution represents a significant improvement over previous studies. Our new high-resolution maps confirm the slow decrease of Q(sub 60) with increasing radial distance from the nucleus, but show additional structure which is probably associated with separate sites of active star formation in the spiral arms. The maps show Q(sub 60) to be more closely related to infrared surface brightness than to the radial distance r in the galaxy disk. We note also that the Q(sub 60) gradients are absent (or at least reduced) for the edge-on galaxies, a property which can be attributed to the dilution of contrast due to the averaging of the additional structure along the line of sight. The results are all in qualitative agreement with the suggestion that the radio image represents a smeared version of the infrared image, as would be expected on the basis of current models in which the infrared-radio correlation is driven by the formation of massive stars, and the intensity distribution of radio emission is smeared as a result of the propagation of energetic electrons accelerated during the supernova phase.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 599-606
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  • 96
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    Is the U-B color sufficient for identifying water of hydration on solar system bodies? (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The U-B color has been suggested as a predictor of the presence of water of hydration on asteroids. Photometry from the Eight-Color Asteroid Survey (ECAS) was used to test this concept. An overlap in U-B color prevents this magnitude difference from distinguishing between surface material that was thermally processed at higher temperatures and surface material that was aqueously altered. Two tests of the presence of water of hydration using visible spectral region photometry failed to flag those few higher albedo M- and E-class asteroids having photometry that shows a 3.0-micrometers water of hydration absorption. These asteroids probably contain little or no oxidized iron in their surface material.
    Keywords: ASTROPHYSICS
    Type: Icarus (ISSN 0019-1035); 115; 1; p. 217-218
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  • 97
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    Monte Carlo simulations of particle acceleration at oblique shocks: Including cross-field diffusion (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Monte Carlo technique of simulating diffusive particle acceleration at shocks has made spectral predictions that compare extremely well with particle distributions observed at the quasi-parallel region of the earth's bow shock. The current extension of this work to compare simulation predictions with particle spectra at oblique interplanetary shocks has required the inclusion of significant cross-field diffusion (strong scattering) in the simulation technique, since oblique shocks are intrinsically inefficient in the limit of weak scattering. In this paper, we present results from the method we have developed for the inclusion of cross-field diffusion in our simulations, namely model predictions of particle spectra downstream of oblique subluminal shocks. While the high-energy spectral index is independent of the shock obliquity and the strength of the scattering, the latter is observed to profoundly influence the efficiency of injection of cosmic rays into the acceleration process.
    Keywords: ASTROPHYSICS
    Type: Advances in Space Research (ISSN 0273-1177); 15; 8-9; p. 397-400
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  • 98
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    Multiparameter linear least-squares fitting to Poisson data one count at a time (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A standard problem in gamma-ray astronomy data analysis is the decomposition of a set of observed counts, described by Poisson statistics, according to a given multicomponent linear model, with underlying physical count rates or fluxes which are to be estimated from the data. Despite its conceptual simplicity, the linear least-squares (LLSQ) method for solving this problem has generally been limited to situations in which the number n(sub i) of counts in each bin i is not too small, conventionally more than 5-30. It seems to be widely believed that the failure of the LLSQ method for small counts is due to the failure of the Poisson distribution to be even approximately normal for small numbers. The cause is more accurately the strong anticorrelation between the data and the wieghts w(sub i) in the weighted LLSQ method when square root of n(sub i) instead of square root of bar-n(sub i) is used to approximate the uncertainties, sigma(sub i), in the data, where bar-n(sub i) = E(n(sub i)), the expected value of N(sub i). We show in an appendix that, avoiding this approximation, the correct equations for the Poisson LLSQ (PLLSQ) problems are actually identical to those for the maximum likelihood estimate using the exact Poisson distribution. We apply the method to solve a problem in high-resolution gamma-ray spectroscopy for the JPL High-Resolution Gamma-Ray Spectrometer flown on HEAO 3. Systematic error in subtracting the strong, highly variable background encountered in the low-energy gamma-ray region can be significantly reduced by closely pairing source and background data in short segments. Significant results can be built up by weighted averaging of the net fluxes obtained from the subtraction of many individual source/background pairs. Extension of the approach to complex situations, with multiple cosmic sources and realistic background parameterizations, requires a means of efficiently fitting to data from single scans in the narrow (approximately = 1.2 keV, HEAO 3) energy channels of a Ge spectrometer, where the expected number of counts obtained per scan may be very low. Such an analysis system is discussed and compared to the method previously used.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 1; p. 322-340
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  • 99
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    Confirmation of interstellar methylene (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Four spectral emission features of the N(sub KK) = 4(sub 04) -3(sub 13) rotational transition of methylene (CH2) have been detected at signal levels 5-7 sigma above noise toward the hot core of the Orion-KL nebula and the molecular cloud in proximity to the continuum source W51 M. Specifically, in both sources we have resolved the F = 6-5, 5-4, and 4-3 hyperfine transitions of the J = 5-4 fine-structure levels and detected the blended hyperfine structure of the J = 4-3 fine structure levels. At the J = 3-2 fine-structure levels, we have observed new transitions of NS, a known interstellar molecule, which severely contaminates the search for CH2 hyperfine transitions. These new sensitive observations finally confirm the existence of interstellar CH2 which was tentatively reported by us some years ago.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 1; p. 259-264
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  • 100
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    Chromospheric models for Altair (A7 IV-V) (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The star, Altair (A7 IV-V), is clearly shown to have Lyman-alpha emission of chromospheric origin, while no evidence is found for the Mg II emission reported in previous investigations. We present non-Local Thermodymanic Equilibrium (non-LTE) semiempirical models incorporating partial redistribution of the chromosphere of Altair that reproduce the observed Lyman-alpha emission and the Mg II resonance absorption at 2800 A. We unambiguously establihed that chromospheres exist at spectral types as early as A7 on the main sequence, and we also demonstrate that it very unlikely that the observed emission originates in a corotating expanding wind. This result represents a new challenge for chromospheric heating theories. It may indicate that both differential rotation and convection layers, at least near the equator, exist in this fast rotating (v sin i = 220 km/s) star.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 1011-1020
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