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  • Chemistry  (82,579)
  • EARTH RESOURCES AND REMOTE SENSING  (3,375)
  • GEOPHYSICS  (3,343)
  • LUNAR AND PLANETARY EXPLORATION  (3,305)
  • 1995-1999  (38,862)
  • 1980-1984  (43,328)
  • 1925-1929
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  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
    Print ISSN: 0036-8075
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
    Print ISSN: 0036-8075
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Evolution of the Pinatubo volcanic cloud over Hampton, Virginia (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The eruption of Mt. Pinatubo in June 1991 produced the largest enhancement of stratospheric aerosol loading ever observed by lidar over Hampton, Virginia. Low altitude layers (less than 20 km) were the first to arrive over Hampton in early August, the result of transport associated with a tropospheric anticyclonic cell over North America. The maximum peak scattering ratio, 34 at 22.4 km, and the maximum stratospheric integrated backscatter of 0.0053 sr(exp -1), both at 694 nm, observed since the eruption were measured on February 20, 1992. After decreasing during the spring and summer of 1992, the aerosol burden increased significantly during the winter of 1992-93, evidence of a poleward winter transport from the equatorial reservoir. Over the period from February 1992 to February 1994, the stratospheric aerosol loading decreased with an average 1/e decay time of 10.1 months. The vertical distribution, intensity, and transport of Pinatubo aerosols over this site are described and compared with similar measurements after El Chichon.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 9; p. 1101-1104
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    Nonsphericity of dust-like tropospheric aerosols: Implications for aerosol remote sensing and climate modeling (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: T-matrix computations of light scattering by polydispersions of randomly oriented nonspherical aerosols and Mie computations for equivalent spheres are compared. Findings show that even moderate nonsphericity results in suubstantial errors in the retrieved aerosol optical thickness if satellite reflectance measurements are analyzed using Mie theory. On the other hand, the use of Mie theory for nonspherical aerosols produces negligible errors in the computation of albedo and flux related quantities, provided that the aerosol size distribution and optical thickness are known beforehand. The first result can be explained by large nonspherical-spherical differences in scattering phase function, while the second result follows from small nonspherical-spherical differences in single-scattering albedo and asymmetry parameter. No cancellation of errors occurs if one consistently uses Mie theory in the retrieval algorithm and then in computing the albedo for the retrieved aerosol optical thickness.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 9; p. 1077-1080
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    Atmospheric gradients from very long baseline interferometry observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Azimuthal asymmetries in the atmospheric refractive index can lead to errors in estimated vertical and horizontal station coordinates. Daily average gradient effects can be as large as 50 mm of delay at a 7 deg elevation. To model gradients, the constrained estimation of gradient paramters was added to the standard VLBI solution procedure. Here the analysis of two sets of data is summarized: the set of all geodetic VLBI experiments from 1990-1993 and a series of 12 state-of-the-art R&D experiments run on consecutive days in January 1994. In both cases, when the gradient parameters are estimated, the overall fit of the geodetic solution is improved at greater than the 99% confidence level. Repeatabilities of baseline lengths ranging up to 11,000 km are improved by 1 to 8 mm in a root-sum-square sense. This varies from about 20% to 40% of the total baseline length scatter without gradient modeling for the 1990-1993 series and 40% to 50% for the January series. Gradients estimated independently for each day as a piecewise linear function are mostly continuous from day to day within their formal uncertainties.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 9; p. 1041-1044
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    Centrifugal trapping in the magnetotail (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Particles leving the neutral sheet in the distant magnetotail at times display adiabatic trajectory sequences characterized by an inflection toward the equator and subsequent mirroring in its vicinity. We demonstrate that this low-latitude mirroring results primarily from a centrifugal deceleration due to the fast direction-changing E x B drift. This effect which we refer to as 'centrifugal trapping' appears both in guiding centre and full particle treatments. It thus does not directly relate to nonadiabatic motion. However, pitch angle scattering due to nonadiabatic neutral sheet interaction does play a role in reducing the parallel speed of the particles. We show that centrifugal trapping is an important mechanism for the confinement of the slowest (typically below the equatorial E x B drift speed) plasma sheet populations to the midplane vicinity.
    Keywords: GEOPHYSICS
    Type: Annales Geophysicae (ISSN 0992-7689); 13; 3; p. 242-246
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    Mass of dust in the Martian atmosphere (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Estimates of the mass of dust suspended in the Martian atmosphere are derived from global and regional 9-micrometer opacity maps produced from Viking Infrared Thermal Mapper data. During the peak of the 1977b storm, a total dust mass of approximately 4.3 x 10(exp 14) g was suspended, equivalent to 4.3 x 10(exp -4) g/sq cm, or a layer 1.4 micrometers thick. During a local dust storm near Solis Planum at L(sub s) 227 deg, approximately 1.3 x 10(exp 13) g of dust were lofted, equal to about a 6-micrometer layer in that vicinity.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E4; p. 7509-7512
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    Volcanic eruptions on Io: Heat flow, resurfacing, and lava composition (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We model an infrared outburst on Io as being due to a large, erupting lava flow which increased its area at a rate of 1.5 x 10(exp 5)/sq m and cooled from 1225 to 555 K over the 2.583-hr period of observation. The inferred effusion rate of 3 x 10(exp 5) cu m/sec for this eruption is very high, but is not unprece- dented on the Earth and is similar to the high eruption rates suggested for early lunar volcanism. Eruptions occur approxi- mately 6% of the time on Io. These eruptions provide ample resurfacing to explain Io's lack of impact craters. We suggest that the large total radiometric heat flow, 10(exp 14) W, and the size and temperature distribution of the thermal anomalies (McEwen et al. 1992; Veeder et al. 1994) can be accounted for by a series of silicate lava flows in various stages of cooling. We propose that the whole suite of Io's currently observed thermal anomalies was produced by multiple, high-eruptive-rate silicate flows within the past century.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 220-225
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    Backscatter model for the unusual radar properties of the Greenland Ice Sheet (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A number of planetary objects exhibit large radar reflectivity and polarization ratios, and more recently, a similar behavior has been observed over a vast portion of the Earth's surface: the percolation facies of the Greenland Ice Sheet. Surface-based ranging radar data and snow stratigraphy studies demonstrated that the radar properties of that portion of Greenland are caused by enhanced scattering from massive, large, solid-ice bodies buried in the top few meters of the dry, cold, clean snowy surface of the ice sheet and created by seasonal melting and refreezing events. Here, we model the icy inclusions as randomly oriented, discrete, noninteracting, dielectric cylinders embedded in a transparent snow medium. An exact analytical solution is used to compute the scattered field from the cylinders. Using this model, we correctly predict the polarimetric radar observations gathered by an airborne imaging system at three wavelengths (5.6, 24, and 68 cm), between 19 deg and 65 deg incidence angle. The diameter and number density of the cylinders that are inferred from the radar data using the model are consistent with in situ observations of the icy inclusions. The large radar reflectivity and polarization ratios are interpreted as arising internal reflections of the radar signals in the icy inclusions that first-order external reflection models fail to predict. The results compare favorably with predictions from the coherent backscatter or weak localization theory and may provide a complementary framework for interpreting exotic radar echoes from other planetary objects.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E5; p. 9389-9400
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    Three-dimensional magnetic reconnection and the magnetic topology of coronal mass ejection events (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Measurements of superthermal electron fluxes in the solar wind indicate that field lines within coronal mass ejections, CMEs, near and beyond 1 AU are normally connected to the Sun at both ends. However, on occasion some field lines embedded deep within CMEs appear to be connected to the Sun at only one end. Here we propose an explanation for how such field lines arise in terms of 3-dimensional reconnection close to the Sun. Such reconnection also provides a natural explanation for the flux rope topology characteristic of many CMEs as well as the coronal loops formed during long-duration, solar X-ray events. Our consideration of the field topologies resulting from 3-dimensional reconnection indicates that field lines within and near CMEs may on occasion be connected to the outer heliosphere at both ends.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 8; p. 869-872
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    Dust torus around Mars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We investigate the orbital dynamics of small dust particles generated via the continuous micrometeoroid bombardment of the Martian moons. In addition to Mar's oblateness, we also consider the radiation pressure perturbation that is complicated by the planet's eccentric orbit and tilted rotational axis. Considering the production rates and the lifetimes of dust grains, we show that particles from Deimos with radii of about 15 micrometers are expected to dominate the population of a permanently present and tilted dust torus. This torus has an estimated peak number density of approximately equals 5 x 10(exp -12)/cu cm and an optical depth of approximately equals 4 x 10(exp -8).
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E2; p. 3277-3284
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    The efficiency of 'viscous interaction' between the solar wind and the magnetosphere during intense northward IMF events (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We examined 11 cases when the interplanetary magnetic field (IMF) was intensely northward (greater than 10 nT) for long durations of time (greater than 3 hours), to quantitatively determine an uppler limit on the efficiency of solar wind energy injection into the magnetosphere. We have specifically selected these large B(sub N) events to minimize the effects of magnetic reconnection. Many of these cases occurred during intervals of high-speed streams associated with coronal mass ejections when viscous interaction effects might be at a maximum. It is found that the typical efficiency of solar wind energy injection into the magnetosphere is 1.0 x 10(exp -3) to 4.0 x 10(exp -3), 100 to 30 times less efficient than during periods of intense southward IMFs. Other energy sinks not included in these numbers are discussed. Estimates of their magnitudes are provided.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 6; p. 663-666
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    A slightly more massive young Sun as an explanation for warm temperatures on early Mars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The valley network channels on the heavily cratered ancient surface of Mars suggest the presence of liquid water approximately 3.8 Gyr ago. However, the implied warm climate is difficult to explain in the context of the standard solar model, even allowing for the maximum CO2 greenhouse heating. In this paper we investigate the astronomical and planetary implications of a nonstandard solar model in which the zero-age, main-sequence Sun had a mass of 1.05 +/- 0.02 Solar Mass. The excess mass was subsequently lost in a solar wind during the first 1.2(-0.2, +0.4) Gyr of the Sun's main sequence phase. The implied mass-loss rate of 4(+3, -2) x 10(exp -11) M/yr, or about 10(exp 3) x that of the current Sun, may be detectable in several nearby young solar type stars.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); p. 5457-5464
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    Geology and landscape evolution of the Hellas region of Mars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Hellas basin on Mars has been the site of volcanism, tectonism, and modification by fluvial, mass-wasting, and eolian processes over its more than 4-b.y. existence. Our detailed geologic mapping and related studies have resulted in the following new interpretations. The asymmetric distribution of highland massifs and other structures that define the uplifted basin rim suggest a formation of the basin by the impact of a low-angle bolide having a trajectory heading S60E. During the Late Noachian, the basin was infilled, perhaps by lava flows, that were sufficiently thick (greater than 1 km) to produce wrinkle ridges on the fill material and extensional faulting along the west rim of the basin. At about the same time, deposits buried northern Malea Planum, which are interpreted to be pyroclastic flows from Amphitrites and Peneus Paterae on the basis of their degraded morphology, topology, and the application of a previous model for pyroclastic volcanism on Mars. Peneus forms a distinctive caldera structure that indicates eruption of massive volumes of magma, whereas Amphitrites is a less distinct circular feature surrounded by a broad, low, dissected shield that suggests generally smaller volume eruptions. During the Early Hesperian, an approximately 1-to 2km-thick sequence of primarily fined-grained, eolian material was deposited on the floor of Hellas basin. Subsequently, the deposit was deeply eroded, except where armored by crater ejecta, and it retreated as much as 200-300 km along its western margin, leaving behind pedestal craters and knobby outliers of the deposit. Local debris flows within the deposit attest to concentrations of groundwater, perhaps in part brought in by outflow floods along the east rim of the basin. These floods may have deposited approximately 100-200m of sediment, subduing wrinkle ridges in the eastern part of the basin floor. During the Late Hesperian and Amazonian, eolian mantles were emplaced on the basin rim and floor and surrounding highlands. Their subsequent erosion resulted in pitted and etched plains and crater fill, irregular mesas, and pedestal craters. Local evidence occurs for the possible former presence of ground ice or ice sheets approximately 100 km across; however, we disagree with a hypothesis that suggest that the entire south rim and much of the floor of Hellas have been glaciated. Orientations of dune fields and yardangs in lower parts of Hellas basin follow directions of the strongest winds predicted by a recently published general circulation model (GCM). Transient frost and dust splotches in the region are, by contrast, related to the GCM prediction for the season in which the images they appear in were taken.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); p. 5407-5432
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    Hematite, pyroxene, and phyllosilicates on Mars: Implications from oxidized impact melt rocks from Manicouagan Crater, Quebec, Canada (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Visible and near-IR refectivity, Moessbauer, and X ray diffraction data were obtained on powders of impact melt rock from the Manicouagan Impact Crater located in Quebec, Canada. The iron mineralogy is dominated by pyroxene for the least oxidized samples and by hematite for the most oxidized samples. Phyllosilicate (smectite) contents up to approximately 15 wt % were found in some heavily oxidized samples. Nanophase hematite and/or paramagnetic ferric iron is observed in all samples. No hydrous ferric oxides (e.g., goethite, lepidocrocite, and ferrihydrite) were detected, which implies the alteration occurred above 250 C. Oxidative alteration is thought to have occurred predominantly during late-stage crystallization and subsolidus cooling of the impact melt by invasion of oxidizing vapors and/or solutions while the impact melt rocks were still hot. The near-IR band minimum correlated with the extent of aleration Fe(3+)/Fe(sub tot) and ranged from approximately 1000 nm (high-Ca pyroxene) to approximately 850 nm (bulk, well-crystalline hematite) for least and most oxidized samples, respectively. Intermediate band positions (900-920 nm) are attributed to low-Ca pyroxene and/or a composite band from hematite-pyroxene assemblages. Manicouagan data are consistent with previous assignments of hematite and pyroxene to the approximately 850 and approximately 1000nm bands observed in Martian reflectivity spectra. Manicouagan data also show that possible assignments for intermediate band positions (900-920 nm) in Martian spectra are pyroxene and/or hematite-pyroxene assemblages. By analogy with impact melt sheets and in agreement with observables for Mars, oxidative alteration of Martian impact melt sheets above 250 C and subsequent erosion could produce rocks and soils with variable proportions of hematite (both bulk and nanophase), pyroxene, and phyllosilicates as iron-bearing mineralogies. If this process is dominant, these phases on Mars were formed rapidly at relativly high temperatures on a sporadic basis throughout the history of the planet. The Manicouagan samples also show that this mineralogical diversity can be accomplished at constant chemical composition, which is also indicated for Mars from the analyses of soil at the two Viking landing sites.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); pp. 5319-5328
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    The Earth's magnetosphere is 165 R(sub E) long: Self-consistent currents, convection, magnetospheric structure, and processes for northward interplanetary magnetic field (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The subject of this paper is a self-consistent, magnetohydrodynamic numerical realization for the Earth's magnetosphere which is in a quasi-steady dynamic equilibrium for a due northward interplanetary magnetic field (IMF). Although a few hours of steady northward IMF are required for this asymptotic state to be set up, it should still be of considerable theoretical interest because it constitutes a 'ground state' for the solar wind-magnetosphere interaction. Moreover, particular features of this ground state magnetosphere should be observable even under less extreme solar wind conditions. Certain characteristics of this magnetosphere, namely, NBZ Birkeland currents, four-cell ionospheric convection, a relatively weak cross-polar potential, and a prominent flow boundary layer, are widely expected. Other characteristics, such as no open tail lobes, no Earth-connected magnetic flux beyond 155 R(sub E) downstream, magnetic merging in a closed topology at the cusps, and a 'tadpole' shaped magnetospheric boundary, might not be expected. In this paper, we will present the evidence for this unusual but interesting magnetospheric equilibrium. We will also discuss our present understanding of this singular state.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3623-3635
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    Localized tearing modes in the magnetotail driven by curvature effects (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The stability of collisionless tearing modes is examined in the presence of curvature drift resonances and the trapped particle effects. A kinetic description for both electrons and ions is employed to investigate the stability of a two-dimensional equilibrium model. The main features of the study are to treat the ion dynamics properly by incorporating effects associated with particle trajectories in the tail fields and to include the linear coupling of trapped particle modes. Generalized dispersion relations are derived in several parameter regimes by considering two important sublayers of the reconnecting region. For a typical choice of parameters appropriate to the current sheet region, we demonstrate that localized tearing modes driven by ion curvature drift resonance effects are excited in the current sheet region with growth time of the order of a few seconds. Also, we examine nonlocal characteristics of tearing modes driven by curvature effects and show that modes growing in a fraction of a second arise when mode widths are larger than the current sheet width. Further, we show that trapped particle effects, in an interesting frequency regime, significantly enhance the growth rate of the tearing mode. The relevance of this theory for substorm onset phase and other features of the substorms is briefly discussed.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3563-3572
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    PULSAUR 2: Rocket and groundbased measurements in a pulsating aurora (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The second pulsating aurora rocket (PULSAUR 2) rocket was launched into a pulsating aurora on 9 February 1994 and carried a broad range of instruments in order to perform a study of this type of aurora. The rocket measurements were complemented with a set of ground-based measurements. The particle measurements performed in the rocket are related to the ground-based optical measurements performed along the rocket trajectory. It is found that the high energy electrons are largely in phase with the measured luminosity. The EISCAT measurements carried out during the flight are reviewed. The PULSAUR 2 campaign is described. Results concerning the auroral conditions and the particle measurements are presented.
    Keywords: GEOPHYSICS
    Type: ESA, Proceedings of 12th ESA Symposium on European Rocket and Balloon Programmes and Related Research; p 233-237
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    High-speed correction factor to the O(+)-O resonance charge exchange collision frequency (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The high-speed correction factor to the O(+)-O collision frequency, resulting from drift velocities between ions and neutrals, is calculated by solving the integral expression in this factor both numerically and analytically. Although the analytic solution is valid for either small or large drift velocities between ions and neutrals, for temperatures of interest and all drift velocities considered, agreement is found between analytic and detailed numerical integration results within less than 1% error. Let T(sub r) designate the average of the ion and neutral temperatures in K, and u = nu(sub d)/alpha, where nu(sub d) is the relative drift velocity in cm/s, and alpha = 4.56 x 10(exp 3) square root of T(sub r) cm/s is the thermal velocity of the O(+)-O system. Then, as u ranges from 0 to 2, the correction factor multiplying the collision frequency increases monotonically from 1 to about 1.5. An interesting result emerging from this calculation is that the correction factor for temperatures of aeronomical interest is to a good approximation independent of the temperature, depending only on the scaled velocity u.
    Keywords: GEOPHYSICS
    Type: Annales Geophysicae (ISSN 0992-7689); 13; 3; p. 253-255
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    An efficient algorithm for choosing scattering directions in Monte Carlo work with arbitrary phase functions (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: This paper describes an efficient Monte Carlo algorithm for choosing a new direction of a photon after a scattering interaction. The algorithm chooses a scattering angle by linear interpolation in a table of the inverse cumulative scattering probability. A Legendre expansion of the phase function makes it easy to apply Clenshaw's algorithm to build the interpolation table. The points in the table are close enough together that linear interpolation is accurate. With a table of 100,000 entries, we can keep the absolute and relative errors in matching the probability distribution below 10(exp -5).
    Keywords: GEOPHYSICS
    Type: Journal of Quantitative Spectroscopy & Radiative Transfer (ISSN 0022-4073); 53; 1; p. 23-38
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    Ice flow dynamics of the Greenland ice sheet from SAR interferometry (1995)
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    Publication Date: 2011-08-24
    Description: Synthetic-aperture radar (SAR) interferograms produced from ESA's ERS-1 satellite, provide the first synoptic view of ice flow dynamics of the western sector of the Greenland Ice Sheet. Glacial motion is detected in the radar ranging direction at millimetric scales, across a complete sequence of snow accumulation and melting regimes, despite significant varations in their radar scattering properties. Ice flow evolves from a slow, regular motion at the higher elevations. At lower elevations, motion is strongly convoluted by meter-scale undulations in surface topography, which have a unique interferometric signature that enables a novel approach for retrieving flow direction. Inferred flow directions, combined with surface displacements in the radar ranging direction, yield ice velocity estimates that are within 6% of in-situ measurements gathered along a 40 km survey line. Application of repeat-pass SAR interferometry to the entire Greenland Ice Sheet should enable precise mapping of its ice flow dynamics at an unprecedented level of spatial detail.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 5; p. 575-578
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    On the uniqueness of linear moving-average filters for the solar wind-auroral geomagnetic activity coupling (1995)
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    Publication Date: 2011-08-24
    Description: The relation between the solar wind input to the magetosphere, VB(sub South), and the auroral geomagnetic index AL is modeled with two linear moving-average filtering methods: linear prediction filters and a driven harmonic oscillator in the form of an electric circuit. Although the response of the three-parameter oscillator is simpler than the filter's, the methods yield similar linear timescales and values of the prediction-observation correlation and the prediction Chi(exp 2). Further the filter responses obtained by the two methods are similar in their long-term features. In these aspects the circuit model is equivalent to linear prediction filtering. This poses the question of uniqueness and proper interpretation of detailed features of the filters such as response peaks. Finally, the variation of timescales and filter responses with the AL activity level is discussed.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A4; p. 5637-5641
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    Modeling the Earth's magnetospheric magnetic field confined within a realistic magnetopause (1995)
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    Publication Date: 2011-08-24
    Description: Empirical data-based models of the magnetosphereic magnetic field have been widely used during recent years. However, the existing models (Tsyganenko, 1987, 1989a) have three serious deficiencies: (1) an unstable de facto magnetopause, (2) a crude parametrization by the K(sub p) index, and (3) inaccuracies in the equatorial magnetotail B(sub z) values. This paper describes a new approach to the problem; the essential new features are (1) a realistic shape and size of the magnetopause, based on fits to a large number of observed crossing (allowing a parametrization by the solar wind pressure), (2) fully controlled shielding of the magnetic field produced by all magnetospheric current systems, (3) new flexible representations for the tail and ring currents, and (4) a new directional criterion for fitting the model field to spacecraft data, providing improved accuracy for field line mapping. Results are presented from initial efforts to create models assembled from these modules and calibrated against spacecraft data sets.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A4; p. 5599-5612
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    The middle atmospheric response to short and long term solar UV variations: analysis of observations and 2D model results (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have investigated the middle atmospheric response to the 27-day and 11-yr solar UV flux variations at low to middle latitudes using a two-dimensional photochemical model. The model reproduced most features of the observed 27-day sensitivity and phase lag of the profile ozone response in the upper stratosphere and lower mesosphere, with a maximum sensitivity of +0.51% per 1% change in 205 nm flux. The model also reproduced the observed transition to a negative phase lag above 2 mb, reflecting the increasing importance with height of the solar modulated HO(x) chemistry on the ozone response above 45 km. The model revealed the general anti-correlation of ozone and solar UV at 65-75 km, and simulated strong UV responses of water vapor and HO(x) species in the mesosphere. Consistent with previous 1D model studies, the observed upper mesospheric positive ozone response averaged over +/- 40 was simulated only when the model water vapor concentrations above 75 km were significantly reduced relative to current observations. In agreement with observations, the model computed a low to middle latitude total ozone phase lag of +3 days and a sensitivity of +0.077% per 1% change in 205 nm flux for the 27-day solar variation, and a total ozone sensitivity of +0.27% for the 11-yr solar cycle. This factor of 3 sensitivity difference is indicative of the photochemical time constant for ozone in the lower stratosphere which is comparable to the 27-day solar rotation period but is much shorter than the 11-yr solar cycle.
    Keywords: GEOPHYSICS
    Type: Journal of Atmospheric and Terrestrial Physics (ISSN 0021-9169); 57; 4; p. 333-365
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    Accuracy of satellite altimeter elevations over the Greenland ice sheet (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The accuracy of Geosat satellite altimetry over the Greenland ice sheet is evaluated by comparing the measured heights to radar elevations from the airborne Greenland Aerogeophysics Project. At the center of the ice sheet where the ice surface is nearly level, surface comparisons show a fit at the 1 to 3 m level as expected, but even at moderately sloping ice regions (0.3 deg-0.6 deg), satellite altimetry mean errors in the range of 10 to 35 m are observed. These errors are found for slope-corrected and waveform-retracked data, so most previous accuracy estimates of current satellite altimetry ice sheet elevations in regions of slopping or undulating ice appear to be too optimistic.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; C2; p. 2687-2696
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    Satellite observations of zonal electric fields near sunrise in the equatorial ionosphere (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report here on a number of examples of anomalous enhancements of eastward electric fields near sunrise in the equatorial ionospheric F-region. These examples were selected from the data base of the equatorial satellite, San Marco D (1988), which measured ionospheric electric fields during a period of solar minimum. The eastward electric fields reported correspond to vertical plasma drifts. The examples studied here are similar in signature and polarity to the pre-reversal electric field enhancements seen near sunset from ground-based radar systems. The morphology of these sunrise events, which are observed on about 14% of the morning-side satellite passes, are studied as a function of local zonal velocity, magnetic activity, geographic longitude and altitude. The nine events studied occur at locations where the zonal plasma flow is generally measured to be eastward, but reducing as a function of local time and at satellite longitudes where the magnetic declination has the opposite polarity as the declination of the sunrise terminator.
    Keywords: GEOPHYSICS
    Type: Journal of Atmospheric and Terrestrial Physics (ISSN 0021-9169); 57; 1; p. 19-24
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    A description of the solar wind-magnetosphere coupling based on nonlinear filters (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A nonlinear filtering method is introduced for the study of the solar wind -- magnetosphere coupling and related to earlier linear techniques. The filters are derived from the magnetospheric state, a representation of the magnetospheric conditions in terms of a few global variables, here the auroral electrojet indices. The filters also couple to the input, a representation of the solar wind variables, here the rectified electric field. Filter-based iterative prediction of the indices has been obtained for up to 20 hours. The prediction is stable with respect to perturbations in the initial magnetospheric state; these decrease exponentially at the rate of 30/min. The performance of the method is examined for a wide range of parameters and is superior to that of other linear and nonlinear techniques. In the magnetospheric state representation the coupling is modeled as a small number of nonlinear equations under a time-dependent input.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3495-3512
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    Topological structure of the magnetotail as a function of interplanetary magnetic field direction (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Magnetic reconnection between the interplanetary magnetic field (IMF) and the geomagnetic field is thought to play a major role in the transfer of solar wind momentum and energy to the magnetosphere. As the angle between the IMF and the geomagnetic field is changed at the bow of the magnetosphere, the topological record of the location of the reconnection region should be recorded in the magnetosheath and on the magnetopause along the flanks of the tail, because the super fast flow freezes strong magnetic gradients formed in the bow reconnection regions into the plasma downstream. In this report, we present results from a three-dimensional, magnetohydrodynamic (MHD), global numerical simulation code for the location of the separatrix between unconnected IMF magnetosheath field lines and reconnected field lines which penetrate the magnetopause and connect to the polar ionosphere. The angle between the IMF direction and the line where the separatrix crosses the magnetopause is shown to be a sensitive function of the IMF clock angle. We also explain how this behavior can be used to derive an approximate relation for the dependence of the cross-polar voltage on the IMF clock angle. We conclude with a note of caution concerning the importance of physical boundary conditions in magnetoplasma simulations.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3613-3621
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    Spatial symmetry breaking in rapidly rotating convective spherical shells (1995)
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    Publication Date: 2011-08-24
    Description: Many problems in geophysical and astrophysical convection systems are characterized by fast rotation and spherical shell geometry. The combined effects of Coriolis forces and spherical shell geometry produce a unique spatial symmetry for the convection pattern in a rapidly rotating spherical shell. In this paper, we first discuss the general spatial symmetries for rotating spherical shell convection. A special model, a spherical shell heated from below, is then used to illustrate how and when the spatial symmetries are broken. Symmetry breaking occurs via a sequence of spatial transitions from the primary conducting state to the complex multiple-layered columnar structure. It is argued that, because of the dominant effects of rotation, the sequence of spatial transitions identified from this particular model is likely to be generally valid. Applications of the spatial symmetry breaking to planetary convection problems are also discussed.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 10; p. 1265-1268
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    Preliminary results from the Sprites94 aircraft campaign: 2. Blue jets (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Initial observations of a newly documented type of optical emission above thunderstorms are reported. 'Blue jets', or narrowly collimated beams of blue light that appear to propagate upwards from the tops of thunderstorms, were recorded on B/W and color video cameras for the first time during the Sprites94 aircraft campaign, June-July, 1994. The jets appear to propagate upward at speeds of about 100 km/s and reach terminal altitudes of 40-50 m. Fifty six examples were recorded during a 22 minute interval during a storm over Arkansas. We examine some possible mechanisms, but have no satisfactory theory of this phenomenon.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 10; p. 1209-1212
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    The contribution of flux transfer events to convection (1995)
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    Publication Date: 2011-08-24
    Description: It is shown from flux transfer event (FTE) occurrence statistics, observed as a function of MLT by the ISEE satellites, that recent 2-dimensional analytic theories of the effects of pulsed Petschek reconnection predict FTEs to contribute between 50 and 200 kV to the total reconnection voltage when the magnetosheath field points southward. The upper limit (200 kV) allows the possibility that FTEs provide all the antisunward transport of open field lines into the tail lobe. This range is compared with the voltages associated with series of FTEs signatures, as inferred from ground-based observations, which are in the range 10-60 kV. We conclude that the contribution could sometimes be made by a series of single, large events; however, the voltage is often likely to be contributed by several FTEs at different MLT.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 10; p. 1185-1188
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    Observations of downward moving O(+) in the polar topside ionosphere (1995)
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    Publication Date: 2011-08-24
    Description: New investigations of the core ion motion within high-latitude topside ionosphere and near-Earth magnetosphere, using data from the Dynamics Explorer (DE) retarding ion mass spectrometer (RIMS), reveal the existence of significant regions of downward moving O(+). The occurences of downgoing versus upgoing O(+) are not clearly separable in terms of either polar zenith angle or Kp but are well distinquished by the direction of the z component of the interplanetary magnetic field (IMF). On the average, down flow dominates when IMFB2 less than O, while upflow dominates for IMFB2 greater than 0. Combining cross-field convection velocities derived from an empirical convection electric field model with the observed parallel velocities yields a two dimensional ion velocity field. This velocity field is consistent with a senario which has O(+) of cusp/cleft and auroral zone origin concvecting into the polar cap and, because of the dominance of gravitational energy over the upward kinetic energy, falling back into the inonsphere. This provides additional confirmation of the results of studies of the cleft ion fountain. Estimates of the flux of O(+) in the upflowing and downflowing regions for Lambda greater than or equal to 60 deg give a total upflow of approximately 6 X 10(exp 25) ions/sec for IMFB2 greater than 0 and total upflow and downflow of approximately 4 X 10 (exp 25) ions/sec and 1 x 10(exp 25) ions/sec, respectively, for IMFB less than 0. In all cases the magnitude of the dayside outflow is consistent with previous work on upwelling ions. While the magnitudes vary for high and low Kp the ratios of upward to downward flow are roughly the same at approximately 1.7. The downflowing O(+) shows a correlation with the magnitude of the outflow of light ions in the same region but the cause and effect of this relationship is not distinquishable. hable.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A4; p. 5795-5800
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    Observations of ice-sheet motion in Greenland using satellite radar interferometry (1995)
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    Publication Date: 2011-08-24
    Description: We present interferometric observations of ice-sheet motion in western Greenland based on pairs of ERS-1 synthetic aperture radar (SAR) images. These observations provide the first detailed regional view of ice motion associated with dynamically supported topography near the margin of an ice sheet. The interferograms of this area are much more complicated than other interferograms of ice sheets presented to date. We devote the largest part of this paper to explaining the source of the complexity in these interferograms. A synthetic interferogram based on a simple model helps to illustrate the effects of different components of the ice velocity field in interferometric data and suggests a method for estimating the large-scale ice velocity field from such data.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 5; p. 571-574
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    Time-domain approach for the transient responses in stratified viscoelastic Earth models (1995)
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    Publication Date: 2011-08-24
    Description: We have developed the numerical algorithm for the computation of transient viscoelastic responses in the time domain for a radially stratified Earth model. Stratifications in both the elastic parameters and the viscosity profile have been considered. The particular viscosity profile employed has a viscosity maximum with a constrast of O(100) in the mid lower mantle. The distribution of relaxation times reveals the presence of a continuous spectrum situated between O(100) and O(exp 4) years. The principal mode is embedded within this continuous spectrum. From this initial-value approach we have found that for the low degree harmonics the non-modal contributions are comparable to the modal contributions. For this viscosity model the differences between the time-domain and normal-mode results are found to decrease strongly with increasing angular order. These calculations also show that a time-dependent effective relaxation time can be defined, which can be bounded by the relaxation times of the principal modes.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 10; p. 1285-1288
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    Plasma gradient effets on doubel-probe measurements in the magnetosphere (1995)
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    Publication Date: 2011-08-24
    Description: The effects on double-probe electric field measurements induced by electron density and temperature gradients are investigated. We show that on some occasions such gradients may lead to marked spurious electric fields if the probes are assumed to lie at the same probe potential with repect to the plasma. The use of a proper bias current will decrease the magnitude of such an error. When the probes are near the plasma potential, the magnitude of these error signals, delta Epsilon, can vary as delta Epsilon approx. T(sub e)(Delta n(sub e)/n(sub e)) + 0.5 Delta T(sub e), where T(sub e) is the electron temperature, Delta n(sub e)/ n(sub e) the relative electron density variation between the two sensors, and Delta T(sub e) the electron temperature difference between the two sensors. This not only implies that the error signals will increase linearly with the density variations but also that such signatures grow with Delta T(sub e) i.e., such effects are 10 times larger in a 10-eV plasma than in a 1-eV plasma. This type of error is independent of the probe separation distance provided the gradient scale length is much larger than the distance. The largest errors occur when the probes are near to the plasma potential. During the crossing of a small structure (e.g, a double layer) the error signal appears as a bipolar signature. Our analysis shows that errors in double-probe measurements caused by plasma gradients are not significant at large scale (much greater than 1 km) plasma boundaries, and may only be important in cases where small-scale (less than 1 km), internal gradient structures exist. Bias currents tailored for each plasma parameter regime (i.e., variable bias current) would improve the double-probe response to gradient effects considerably.
    Keywords: GEOPHYSICS
    Type: Annales Geophysicae (ISSN 0992-7689); 13; 2; p. 130-146
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    Evolution of the Pinatubo volcanic aerosol column above Pasadena, California observed with a mid-infrared backscatter lidar (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The evolution of the volcanic debris plume originating from the June 1991 eruption of Mt. Pinatubo has been monitored since its genesis using a ground-based backscatter lidar facility sited at the Jet Propulsion Laboratory (JPL). Both absolute and relative pre- and post-Pinatubo backscatter observations are in accord with Mie scattering projections based on measured aerosol particle size distributions reported in the literature. The post-Pinatubo column-integrated backscatter coefficient peaked approximately 400 days after the eruption, and the observed upper boundary of the aerosol column subsided at a rate of approximately 200 m/mon.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 7; p. 807-810
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    Uplift of the Kenai Peninsula, Alaska, since the 1964 Prince William Sound earthquake (1995)
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    Publication Date: 2011-08-24
    Description: Using Global Positioning System (GPS) receivers, we reoccupied several leveling benchmarks on the Kenai Peninsula of Alaska which had been surveyed by conventional leveling immediately following the March 27, 1964, Prince William Sound earthquake (M(sub w) = 9.3). By combining the two sets of measurements with a new, high-resolution model of the geoid in the region, we were able to determine the cumulative 1993-1964 postseismic vertical displacement. We find uplift at all of our benchmarks, relative to Seward, Alaska, a point that is stable according to tide gauge data. The maximum uplift of about 1 m occurs near the middle of the peninsula. The region of maximum uplift appears to be shifted northwest relative to the point of maximum coseismic subsidence. If we use tide gauge data at Nikishka and Seward to constrain the vertical motion, then the observed uplift has a trenchward tilt (down to the southeast) as well as an arching component. To explain the observations, we use creep-at-depth models. Most acceptable models require a fault slip of about 2.75 m, although this result is not unique. If the slip has been continuous since the 1964 earthquake, then the average slip rate is nearly 100 mm/yr, twice the plate convergence rate. Comparing the net uplift achieved in 29 years with that observed over 11 years in an adjacent region southeast of Anchorage, Alaska, we conclude that the rate of uplift is decreasing. A further decrease in the uplift rate is expected as the 29-year averaged displacement rate is about twice the plate convergence rate and therefore cannot be sustained over the entire earthquake cycle.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; B2; p. 2031-2038
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    Electron structures in the cusp/cleft region observed by DE 2 satellite (1995)
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    Publication Date: 2011-08-24
    Description: Narrow enhancements of electron precipitation, with energy and flux well above typical values, have been observed with Dynamics Explorer 2 (DE 2) in the cusp/cleft region. The electron flux in the energy range 0.2-1 keV was 2 orders of magnitude higher in these structures than in the magnetosheath and were seen in approximaetly 80% of DE 2 cusp crossings at ionospheric altitudes. Typically, there was more than one electron structure in each cusp crossing. The position of these structures showed a systematic variation: for poleward ion dispersion (energy decreases with increasing latitude), electron structures were seen more often on the equatorial boundary of the cusp, while for equatorward ion dispersion (energy decreases with decreasing latitude), electron structures were more often seen on the poleward boundary. This suggests that the electron structures are associated with newly reconnected field lines. The electron spectra suggest that field-aligned acceleration processes could produce the electron structures, first near the boundary of the cusp/cleft during the reconnection of field lines and then in the cusp/cleft during the motion of reconnected flux tubes through the polar ionosphere.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A2; p. 1597-1610
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    Inflation of Long Valley Caldera from 1 year of continuous GPS observations (1995)
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    Publication Date: 2011-08-24
    Description: A permanent Global Positioning System (GPS) receiver at Casa Diablo Hot Springs, Long Valley Caldera, California was installed in January, 1993, and has operated almost continuously since then. The data have been transmitted daily to the Jet Propulsion Laboratory (JPL) for routine analysis with data from the Fiducial Laboratories for an International Natural sciences Network (FLINN) by the JPL FLINN analysis center. Results from these analyses have been used to interpret the on going deformation at Long Valley, with data excluded from periods when the antenna was covered under 2.5 meters of snow and from some periods when Anti Spoofing was enforced on the GPS signal. The remaining time series suggests that uplift of the resurgent dome of Long Valley Caldera during 1993 has been 2.5 +/- 1.1 cm/yr and horizontal motion has been 3.0 +/- 0.7 cm/yr at S53W in a no-net-rotation global reference frame, or 1.5 +/- 0.7 cm/yr at S14W relative to the Sierra Nevada block. These rates are consistent with uplift predicted from frequent horizontal strain measurements. Spectral analysis of the observations suggests that tidal forcing of the magma chamber is not a source of the variability in the 3 dimensional station location. These results suggest that remotely operated, continuously recording GPS receivers could prove to be a reliable tool for volcanic monitoring throughout the world.
    Keywords: GEOPHYSICS
    Type: Geopysical Research Letters (ISSN 0094-8276); 22; 3; p. 195-198
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    Comparison between SAGE II and ISCCP high-level clouds. 2: Locating clouds tops (1995)
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    Publication Date: 2011-08-24
    Description: A comparison is made of the vertical distribution of high-level cloud tops derived from the Stratospheric Aerosol and Gas Experiment II (SAGE II) occultation measurements and from the International Satellite Cloud Climatology Project (ISCCP) for all Julys and Januarys in 1985 to 1990. The results suggest that ISCCP overestimates the pressure of high-level clouds by up to 50-150 mbar, particularly at low latitudes. This is caused by the frequent presence of clouds with diffuse tops (greater than 50% time when cloudy events are observed). The averaged vertical extent of the diffuse top is about 1.5 km. At midlatitudes where the SAGE II and ISCCP cloud top pressure agree best, clouds with distinct tops reach a maximum relative proportion of the total level cloud amount (about 30-40%), and diffuse-topped clouds are reduced to their minimum (30-40%). The ISCCP-defined cloud top pressure should be regarded not as the material physical height of the clouds but as the level which emits the same infrared radiance as observed. SAGE II and ISCCP cloud top pressures agree for clouds with distinct tops. There is also an indication that the cloud top pressures of optically thin clouds not overlying thicker clouds are poorly estimated by ISCCP at middle latitudes. The average vertical extent of these thin clouds is about 2.5 km.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; D1; p. 1137-1147
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    Comparison between SAGE II and ISCCP high-level clouds. 1: Global and zonal mean cloud amounts (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Global high-level clouds identified in Stratospheric Aerosol and Gas Experiment II (SAGE II) occultation measurements for January and July in the period 1985 to 1990 are compared with near-nadir-looking observations from the International Satellite Cloud Climatology Project (ISCCP). Global and zonal mean high-level cloud amounts from the two data sets agree very well, if clouds with layer extinction coefficients of less than 0.008/km at 1.02 micrometers wavelength are removed from the SAGE II results and all detected clouds are interpreted to have an average horizontal size of about 75 km along the 200 km transimission path length of the SAGE II observations. The SAGE II results are much more sensitive to variations of assumed cloud size than to variations of detection threshold. The geographical distribution of cloud fractions shows good agreement, but systematic regional differences also indicate that the average cloud size varies somewhat among different climate regimes. The more sensitive SAGE II results show that about one third of all high-level clouds are missed by ISCCP but that these clouds have very low optical thicknesses (less than 0.1 at 0.6 micrometers wavelength). SAGE II sampling error in monthly zonal cloud fraction is shown to produce no bias, to be less than the intraseasonal natural variability, but to be comparable with the natural variability at longer time scales.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; D1; p. 1121-1135
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    Relativistic electron fluxes in May 1992 and their effect on the middle atmosphere (1995)
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    Publication Date: 2011-08-24
    Description: Enhancements in the fluxes of relativistic electrons trapped within the Earth's magnetosphere have been measured by the high-energy particle spectrometer, part of the particle environment monitor on the upper atmosphere research satellite (UARS). The largest increase in the electron fluxes with energies greater than 1 MeV observed on UARS from October 1991 through July 1994 was in early May 1992. The fluxes of trapped electrons in the drift loss cone and locally precipitating electrons showed differing buildup and decay rates as a function of invariant latitude. Increases of more than 2 orders of magnitude were observed in drift loss cone fluxes at magnetic latitudes of 40 deg-66 deg and in precipitating fluxes from 48 deg to 66 deg. The energy flux contained in the most intense local precipitation observed was approximately 0.1 erg/sq cm/s, entering the atmosphere and creating up to 1000 ion pairs/cu cm/s at 55-km altitude. The daily averaged energy flux from directly precipitating electrons with energies greater than 1 MeV deposited greater than 10(exp 20) erg/d worldwide into the atmosphere for the period May 12-21, 1992, producing greater than 10(exp 31) odd nitrogen molecules below 60-km altitude.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; D1; p. 1027-1033
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    Curatorial functions and the U.S. Antarctic meteorite program (1981)
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    Details
    Publication Date: 2011-08-24
    Description: The discovery of concentrations of meteorites in Antarctica by Japanese field parties in 1969, and subsequently by joint U.S.-Japanese and U.S. field parties since 1976 has provided a significant new resource for understanding the origin and evolution of the solar system. The number of meteorites as well as the variety of meteorites has increased dramatically, and substantial amounts of data derived from their study has begun to appear in the scientific literature. The U.S. program of investigation has drawn on curatorial experience derived from the lunar program to: (1) develop specific collection and preliminary examination protocols; (2) provide documented samples for scientific investigations in response to specific requests; and (3) coordinate research by scientific consortia. The productivity of scientific research is significantly enhanced by these management approaches. Some of the results of the curatorial program for Antarctic meteorites carried out over the past three years are described.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: National Institute of Polar Research, Memoirs (ISSN 0386-0744); 20, D
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    Total and spectral solar irradiance measured at ground surface (1982)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: This paper presents the results of a series of total and spectral solar irradiance measurements made at ground surface (Table Mountain Facility, Calif., altitude 2.18 km). The spectral irradiance data are presented for the 0.3-3.0-micron spectral region for air mass 1.5.
    Keywords: GEOPHYSICS
    Type: Applied Optics (ISSN 0003-6935); 21; 3, Fe
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  • 77
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    Computer processed LANDSAT data (1982)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: Background information and exercises are provided to: (1) establish or expand understanding of the concepts, methods, and terminology of computer processing of image producing data; (2) develop insight into the advantages of computer based image processing compared with the photointerpretation approach for processing, classifying, interpreting, and applying remote sensing data; (3) foster a broad perspective on the principal of the main techniques for image enhancement, pattern recognition, and thematic classification; (4) appreciate the pros and cons of batch and interactive modes of image analysis; (5) examine and evaluate some specific computer generated products for subscenes in Pennsylvania and New Jersey; and (6) interrelate these particular examples of output with more theoretical explanations of computer processing strategies and procedures.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The LANDSAT Tutorial Workbook; p 145-232
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  • 78
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    Classification of volcanoes of the Kane Patera Quadrangle of Io: Proportions of lava flows and pyroclastic flows (1984)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: Voyager 1 images show 14 volcanic centers wholly or partly within the Kane Patera quadrangle of Io, which are divided into four major classes: (1) shield with parallel flows; (2) shield with early radial fan shapd flows; (3) shield with radial fan shaped flows, surfaces of flows textured with longitudinal ridges; and (4) depression surrounded by plateau-forming scarp-bounded, untextured deposits. The interpretation attempted here hinges largely on the ability to distinguish lava flows from pyroclastic flows by remote sensing.
    Keywords: GEOPHYSICS
    Type: NASA, Washington Rept. of Planetary Geol. Program, 1983; p 127-129
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  • 79
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    Ode to gravity: Depth/diameter for fresh craters on Mercury (1984)
    In:  CASI
    Details
    Publication Date: 2009-11-23
    Description: Opinions conflict over the role of surface gravity in shaping impact craters on Mercury. One view holds that the effects of g are evident in measurable aspects of crater form; other investigators find little or no evidence for g's geomorphic importance. Ambiguity in the role of g and other variables in cratering on Mercury stems largely from uncertainty in identifying major geomorphic contrasts and the crater sizes at which they occur. One of these, depth/diameter (d/D), undergoes a major change at the transition from simple (bowl shaped) to complex (peaks and terraces) crater interiors. Four least-squares d/D fits for fresh craters on Mercury were attemped. The results are inconsistent. The d/D data that should resolve previous shortcomings is presented. The revised d/D distributions for simple and complex craters, which intersect at a diameter of about 5 km, support the initial thesis that g substantially influences the form of Mercury's craters.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 104-106
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  • 80
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    A proposal for observations of upper and middle tropospheric clouds (1982)
    In:  CASI
    Details
    Publication Date: 2008-07-17
    Description: A proposal for a multi-institutional investigation of the processes involved in the growth and maintenance of high level extended clouds is presented. Mapping of variability of the cloud and of its radiative characteristics in terms of the meteorological environment of the cloud; performance of case studies involving observation of the cloud microphysics and radiation characteristics; and investigation of the processes responsible for the generation, maintenance, and dissipation of the cloud system are recommended. Both modeling and monitoring activities are considered. The specific research projects which the author proposes to carry out are described. Suggestions for the administrative organization of the total effort are presented.
    Keywords: GEOPHYSICS
    Type: Initial Studies of Middle and Upper Tropospheric Stratiform Clouds; 56 p
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  • 81
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    A middle and upper tropospheric cloud model (1982)
    In:  CASI
    Details
    Publication Date: 2008-07-17
    Description: The interplay of the various physical processes involved in the formation, maintenance, and decay of middle and upper tropospheric stratiform clouds is discussed. Ice phase fair weather cloud forms are considered. Simulations of cirriform clouds which attempt to incorporate the physical processes in an interactive manner were performed. A two dimensional time dependent Eulerian numerical model, which incorporates all of the important physical processes in a simplified way, is employed to investigate the role of these processes in the evolution of a cloud in an isolated atmospheric layer. Physical parameters considered are the eddy viscosity and the thermal, water vapor, and ice water eddy diffusivities.
    Keywords: GEOPHYSICS
    Type: Initial Studies of Middle and Upper Tropospheric Stratiform Clouds; 189 p
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  • 82
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    Relationships and tectonics of the Jg-7 quadrangle of Ganymede (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Craters within the Ganymede Jg-7 quadrangle were divided into seven mappable units. The units represent: (1) irregular or elongate craters, (2) craters with dark ejecta, (3) palimpsests, (4) secondary craters, (5) and craters of young, mature, and old age. Symbols used for crater floors include: (1) flat floors, (2) floors with pits, (3) floora with a central dome or peak, (4) and floors with a central dome and pit. Grooved terrains were divided into five mappable units. Three units of light grooved material represent small, medium, and large grooves, which are arbitrarily divided. The other two units of grooved terrain represent dark grooved materials, and reticulate grooves. Two units of ungrooved dark terrain and two units of ungrooved light terrain were defined. In Galileo Regio, two units were defined repesenting large furrowed grooves, and smaller grooves which are orthogonal to the furrowed grooves.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 314-316
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  • 83
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    Mars paleostratigraphy (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: The relative time of emplacement of some major rock units on Mars was recognized to some degree from geologic mapping using Mariner Images. Correlation charts showing the map units and their position in sequence, however, displayed little discrimination in their vertical range of occurrence. A more detailed time-stratigraphy is currently being developed as Viking geologic mapping of the planet progresses.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 296-297
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  • 84
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    Mapping and geological analysis of Mercury radar data (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Although many radar profiles and images of the area within 20 deg of Mercury's equator had been obtained from 1971 to 1981, at both Goldstone and Arecibo radar facilities, surprisingly little geological analysis had been done with these data until recently. Topographic profiles and radar roughness reflectivity images which can be derived from these data will be crucial in completing the geological mapping of Mercury now underway at the U.S. Geological Survey. Processing of available radar data must be completed to establish any systematic relationship between radar reflectivities and roughness, density, dielectric constant, and other related geological parameters. Specific tasks accomplished for these purposes include the following. Documentation was located and searched to establish the type and quantity of Goldstone 12.5 cm radar observations which were available for Mercury. Data has been collected during approximately 50 observation periods from 1971 to 1981. About half of the data, collected during 1972 and 1973, have been processed, but without adequate documentation. A standardized, well-documented procedure for processing and analysis for all Goldstone Earth-based observations of Mercury was established.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 284-286
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  • 85
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    The case for aeolian control of meter-scale surface texture on Mars (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: The origin of Mars surface units and the extent of subsequent cratering play key roles in determining surface texture. At scale sizes of 0.1-10 meters, however, there is a growing body of evidence that wind is the dominant force. The direct and indirect evidence which implies that meter-scale surface texture on Mars is controlled by the wind is presented. Since radar is uniquely sensitive to structure on these scales, radio wave scattering data can provide insight on aeolian activity available from no other source.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 273-275
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  • 86
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    Interpretation of planetary stress systems: Determination of tectonic over-printing in Northwest Wyoming (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Structural and tectonic interpretations of planetary surfaces rely strongly on visual determination of regional structural grain. This grain can be very complex and confusing, and sorting out of discrete trends in time and space is of utmost importance. This study is a test of these techniques applied to a well known area having several discrete structural grains. In the Bighorn Basin region of Wyoming, a largely overlooked N10E structural grain has been verified with detailed structural analysis and indicates a significant change in stress orientation at the end of the Laramide orogeny.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 307-309
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  • 87
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    Ancient volcano-tectonic structures of the Olympus Mons Region, Mars (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Two old volcano-tectonic collapse structures are exposed north and northeast of the huge shield volcano, Olympus Mons. They are semicircular and were probably low shield volcanoes similar to Alba Patera, but whose central portions have subsided or collapsed. They form the basement upon which younger volcanic materials of Alba Patera Olympus Mons have been emplaced. The oldest structure, Acheron Fossae is over 700 km across and is north of Olympus Mons. It has a surface of considerable relief broken by graben and extensive en echelon and parallel fractures and faults with varied displacements. Acheron Fossae is the most densely cratered in the Olympus Mons region. The structure must have formed very early in martian time. The second is Halex Fossae, northeast of Olympus Mons. Where exposed, it is cut by a series of arcuate grabens that become closer spaced toward its center. The radii of the fractures indicate that the structure may be at least 250 km across and centered beneath the Olympus Plains. Lava flows appear to have issued from some of the arcuate fractures and to have flowed radially away from the center of Halex Fossae. North of Halex Fossae, material of the same age as Halex Fossae overlaps Acheron Fossae.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 293-295
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  • 88
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    Radar-visible wind streaks in the Altiplano of Bolivia (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Isolated knobs that are erosional remnants of central volcanoes or of folded rocks occur in several areas of the Altiplano are visible on both optical and images. The optically visible streaks occur in the immediate lee of the knobs, whereas the radar visible streaks occur in the zone downwind between the knobs. Aerial reconnaissance and field studies showed that the optically visible streaks consist of a series of small ( 100 m wide) barchan and barchanoid dunes, intradune sand sheets, and sand hummocks (large shrub coppice dunes) up to 15 m across and 5 m high. On LANDSAT images these features are poorly resolved but combine to form a bright streak. On the radar image, this area also appears brighter than the zone of the radar dark streak; evidently, the dunes and hummocks serve as radar reflectors. The radar dark streak consists of a relatively flat, smooth sand sheet which lacks organized aerolian bedforms, other than occasional ripples. Wind velocity profiles show a greater U value in the optically bright streak zone than in the radar dark streak.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 271-272
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  • 89
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    Thermal infrared analysis of volcanic surfaces: Mars and Hawaii (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: High spatial resolution data from the Viking infrared thermal mapper (IRTM) are used to examine the Tharsis volcanoes which are situated within a vast area of low thermal inertia material very fine particle size or very high porosity, with the volcanoes having the lowest thermal inertias. Thermal infrared images of the 1823 flow on Kilauea's southwest rift zone show lower thermal inertias near the vent area where shelly pahoehoe is common while individual channelized aa flows with abundant broken pahoehoe slabs are higher thermal inertia. The increase in aa flows to the southeast leads to a general trend of increasing thermal inertias from near vent to distal areas. Martian shield volcanoes have thermal inertias equal to or higher than their surrounding plans when atmospheric effects are removed from the data. The general increase in thermal inertias away from the summit calderas is consistent with the trend of the Hawaiian 1823 flow and may be related to changing lava properties away from the summit.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 266-267
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  • 90
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    Galilean satellite multispectral data base production (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: A photometrically and geometrically reduced data base is being produced for the Galilean Satellites using Voyager Imaging data. The basic data set used is essentially all the useful satellite images returned by Voyager. Each frame was radiometrically calibrated and many are projected into cartographic formats. Mosaics of low, medium and high resolution frames being made for each satellite consist of registered digital images with intensity values scaled through a traceable calibration procedure to normal albedo values. Many of the mosaics are being made in two versions. One version is an albedo version and the second is a maximum discrimination version in which large variations in brightness across the picture are suppressed.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 259-260
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  • 91
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    Inversion of topography in Martian highlands terrains (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: One unique feature on Mars is the presence of ring furrows which are apparently produced by inversion of topography at the rims of partially buried craters. Ring furrows are flat-floored trenches, circular in plan view, forming rings 7 to 50 km in diameter. The moat is on the order of 0.5 km deep and 2 to 10 km wide, and it surrounds a flat topped circular mesa or plateau that is 5 to 40 km across. The central plateau is at the same elevation or lower than the surrounding plain outside the ring. The circular nature and size range of ring furrows tend to suggest that these features are related to craters partially buried by younger lava flows. The rings have been formed by preferential removal of the exposed crater rims. Ground ice decay, sapping, or fluvial erosion removed the less resistant, porous material of crater rims while leaving the more resistant volcanic flow material. Differential erosion has thus led to a reversal of topography in which the original positive relief of the rim is reduced to a negative relief feature.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geology Program, 1983; p 228-229
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  • 92
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    Permafrost on Mars: distribution, formation, and geological role (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: The morphology of channels, valleys, chaotic and fretted terrains and many smaller features on Mars is consistent with the hypothesis that localized deterioration of thick layers of ice-rich permafrost was a dominant geologic process on the Martian surface. Such ground ice deterioration gave rise to large-scale mass movement, including sliding, slumping and sediment gravity flowage, perhaps also catastropic floods. In contrast to Earth, such mass movement processes on Mars lack effective competition from erosion by surface runoff. Therefore, Martian features due to mass movement grew to reach immense size without being greatly modified by secondary erosional processes. The Viking Mission to Mars in 1976 provided adequate measurements of the relevant physical parameters to constrain models for Martian permafrost.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 209-211
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  • 93
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    The erosion of streamlined islands, longitudinal grooves and scour marks: Implications to the origin of the Martian outflow channels (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: The diversity of proposed origins for large Martian outflow channels results from the differing interpretations given to the landforms associated with the outflow channels. In an attempt to help limit the possible mechanisms of channel erosion, detailed studies of three of the channel features were done; the streamlined islands, longitudinal grooves and scour marks. This examination involved a comparison of the martian streamlined islands with various streamlined landforms on Earth including those found in the Channel Scabland in large rivers, glacial drumlins, and desert yardangs. The comparisons included statistical analyses of the landform lengths versus widths and positions of maximum width, and an examination of the degree of shape agreement with the geometric lemniscate which was in turn demonstrated to correspond closely with true airfoil shapes. The analyses showed that the shapes of the martian islands correspond closely to the streamlined islands in rivers and the Channel Scabland land. Drumlins show a much smaller correlation. Erosional rock islands formed by glaciers are very much different in shape.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 200-202
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  • 94
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    Dark streaks on talus slopes, Mars (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: High-resolution pictures of talus slopes on Mars show small, dark streaks that characteristically widen downward. These streaks are different from the thin and even streaks of various albedos that stream from cliffs on talus slopes, but gradations between the two streak types occur and not all streaks can be classified with confidence. In order to study the nature and origin of the small, widening, dark streaks, all Viking pictures with a resolution of less than 100 m/pixel were surveyed. To date several hundred streaks were located, but only few are of high enough resolution to be confidently identified as widening downwards. The approximate dimensions of the streaks were measured and their shapes, numbers, position, and spacing on slopes were noted. They were plotted on a topographic map, and their relation to topography, geologic units, and regions of distinct thermal inertia and albedo were studied. Also noted was the season at which images containing streaks were acquired and the direction of illumination. Albedo measurements are in progress. Several streaks can be seen stereoscopically, but none are observed on color images. The observation of small dark streaks on talus slopes on Mars is compatible with an interpretation of their origin as eruptions of small masses of wet debris in places where steep walls intersect aquifers or where seasonal equatorial warming permits the local melting of ground ice.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 188-190
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  • 95
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    Freezing of Martian streams under climatic conditions (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: The valley networks of Mars are widely believed to have formed at a time when climatic conditions on the planet were significantly different from those that currently prevail. This view arises from the following observations: (1) the valleys form integrated branching networks which suggests fluid drainage, and water is the most plausible fluid, (2) the present atmosphere contains only minute amounts of water, (3) the networks appear to be more akin to terrestrial valleys that are eroded by streams of modest discharges than features that form by catastrophic floods, and (4) small streams of water will rapidly freeze under present climatic conditions. Climatic conditions at the time of formation of the valleys are studied based on the assumption that they were cut by running water.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Rept. of Planetary Geol. Programs; p 185-187
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  • 96
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    Venus: The nature of the surface from Venera panoramas (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Images of the surface of Venus obtained by the Soviet Venera 9, 10, 13 and 14 landers are analyzed to provide a basis for understanding the nature of geologic processes operating there. Bedrock is exposed at the Venera 10, 13 and 14 sites and is characterized by semi-continuous, flat polygonal to subrounded patches up to several meters in width. The bedrock surface is often dominated by sub horizontal to horizontal layered plates with thicknesses of several cm and abundant linear and polygonal vertical fractures. Soils (particles 1 cm) are abundant at the Venera 9, 10 and 13 sites, but are uncommon at Venera 14. Features indicative of a strong aeolian influence (moats, dunes, wind tails) are not observed. Several hypotheses are considered for the origin of the bedrock surfaces, and it is concluded that bedrock originated from surface lava flows. The relative freshness of features observed by the Veneras suggests that erosion rates are very low or that some bedrock surfaces are geologically young.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Repts. of Planetary Geol. Program; p 76-78
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  • 97
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    Venus banded terrain: Evaluation of tectonic models for the origin of banding (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: A tectonic orgin for Venus banded terrain is consistent with band spacing. Both compressional (folding) and extensional models for band formation can fit present observations. Band spacing cannot distinguish among scenarios for global heat loss and for the origin of highland terrain. Tectonic models for band formation indicate that the surface brittle layer in the venus highlands is no more than a few kilometers thick.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Repts. of Planetary Geol. Program; p 74-75
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  • 98
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    Wind abrasion on Venus: A means for experimental investigations (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: A study to determine the feasibility of conducting experiments to simulate the aeolian environment on Venus as related to wind abrasion was completed. Ideally, such experiments should involve complete investigation of weathering, in which mechanical, thermal, and chemical parameters are taken into account. This is particularly important for Venus, where atmospheric temperatures and pressures at the surface produce an environment which is equivalent to low or medium grade metamorphic conditions on Earth. Details that describe the Venus Aeolian Abrasion Device (VAAD) are included. The VAAD device would enable experiments to be conducted with the same chemistry, temperature, pressure, and other physical properties of the Venus atmosphere near the surface. The proposed device enables the important aeolian parameters to be controlled and monitored, including particle size, velocity, impact-angle and flux, atmospheric pressure, temperature, and gas composition.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA. Washington Repts. of Planetary Geol. Program; p 67-68
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  • 99
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    Volcanism in the Valles Marineris (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Tectoism in the Valles Marineris appears to have been accompanied by volcanism. The proposed volcanic features, though probably contemporaneous with the gigantic ones in the Tharsis area, are composed of small, mafic and, possibly, somewhat larger felsic flows. The size of these features is similar to that of volcanic flows on the Earth.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 135-137
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  • 100
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    Experiments on water/melt explosions, nature of products, and models of dispersal (1984)
    In:  CASI
    Details
    Publication Date: 2006-04-06
    Description: Experiments were carried out in a steel pressure device using controlled amounts of water and thermite melt to examine the mechanical energy released on explosive mixing following the initial contact of the two materials. An experimental design was used to allow the direct calculation of the mechanical energy by the dynamic lift of the device as recorded both optically and physically. A large number of experiments were run to accurately determine the optimum mixture of water and melt for the conversion of thermal to mechanical energy. The maximum efficiency observed was about 12% at a water/thermite mass ratio of 0.50. These experiments are the basis for the development of models of hydroexplosions and melt fragmentation. Particles collected from the experimental products are similar in size and shape to pyroclasts produced by much larger hydrovolcanic explosions. Melt rupture at optimum ratios produces very fine particles whereas rupture at high or low water/melt ratios produces large melt fragments. Grain surface textures in the experimental products are also related to the water/melt ratio and the mechanism of explosive mixing. It is thus possible to have qualitative information about the nature of the explosion from the sizes and shapes of the fragments produced.
    Keywords: GEOPHYSICS
    Type: NASA. Washington Rept. of Planetary Geol. Program, 1983; p 144-146
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