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  • Chemistry  (82,579)
  • General Chemistry  (16,150)
  • Analytical Chemistry and Spectroscopy  (6,520)
  • ASTROPHYSICS  (3,362)
  • ASTRONOMY
  • 1995-1999  (39,181)
  • 1980-1984  (38,418)
  • 1925-1929
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  • 1
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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  • 3
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 4
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 5
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 6
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 7
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 8
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
    Print ISSN: 0036-8075
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  • 9
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 11
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 12
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 13
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 14
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 15
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 16
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 18
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 19
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 20
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 21
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 22
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 23
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 24
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 26
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 28
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 29
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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  • 30
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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  • 31
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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  • 32
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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  • 33
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 34
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 35
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    Other groundbased observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Ground-based solar observational programs are discussed. The Birmingham (U.K.) solar oscillation network (BiSON) program, the Crimean (Ukraine) low degree program, the Stanford (California) low degree program, the Tenerife (Spain) group program, the South Pole program, the Mount Wilson (California) program, the international research on the interior of the sun (IRIS) network program, the high-l helioseismometer instrument, the ground luminosity oscillations imager (LOI) program, and the Taiwanese oscillation network (TON) program, are outlined.
    Keywords: ASTRONOMY
    Type: ESA, Proceedings of 4th SOHO on Helioseismology. Volume 1: Invited Reviews and Working Group Reports; p 107-111
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  • 36
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    Potential applications of GSC-2 for GAIA operations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The second guide star catalog (GSC-2) is a project that aims to create a complete catalog of stars and galaxies to about the 18th magnitude, and would contain colors, magnitudes, positions and proper motions. The catalog would provide an object list for the construction of an input catalog for possible future astrometric satellites, such as the global astrometric interferometer for astrophysics (GAIA) satellite. With a schedule that is compatible with the projected timeframe of GAIA, the GSC-2 could be available in time to support the preparatory astrophysical observations for an input catalog. The availability of the digitalized images for the preparation of finding charts would improve the efficiency of this task.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 137-141
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  • 37
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    Another look at the UBV variability of T Tauri stars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The UBV variability of classical T Tauri stars is investigated using a large data set compiled by Herbst et al. (1994). The analysis is based on the covariance of the UBV colors, which is independent of the obscuration and the temporal sampling, and is a powerful tool for finding trends that otherwise would be hidden in the complex time-dependence of the data. I find that there are two types of UBV variability and introduce the nomenclature 'ortho-' and 'para-UBV' variations, or in short 'type-O' and 'type-P' variations. Objects with a predominance of ortho-UBV variability show strong variability in both the Balmer and Paschen continua, whereas objects dominated by para-UBV changes vary mostly in the Paschen continuum. I show that type-O variations can be explained in terms of rotating spots, variable obscuration, or changes intrinsic to the source that obey the law Delta T(sub S)/T(sub S) varies as Delta n(sub H)/n(sub H), where T(sub S) and n(sub H) are, respectively, the gas temperature and the number density of hydrogen nuclei. Type-P variations can be explained only by changes intrinsic to the source with Delta T(sub S)/T(sub S) varies as - Delta n(sub H)/n(sub H), and I speculate on a possible origin for these changes. The covariance ellipse of the UBV colors is a versatile tool for studying the connection between variability and other spectral signatures of classical T Tauri stars; its use for this purpose is illustrated by studying the correlation between the presence of CO first-overtone bands in emission and the type of variability. I find that objects with CO band emission are also those with type-P variability and propose an observational test to validate this conclusion.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 2; p. 818-830
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  • 38
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    Time delay in the Einstein ring PKS 1830-211 (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present radio observations of the gravitational lens PKS 1830-211 at 8.4 and 15 GHz acquired using the Very Large Array. The observations were made over a 13 month period. Significant flux density changes over this period provide strong constraints on the time delay between the two lensed images and suffest a value of 44 +/- 9 days. This offers new direct evidence that this source is indeed a gravitational lens. The lens distance is dependent upon the model chosen, but reasonable limits on the mass of the lensing galaxy suggest that it is unlikely to be at a redshift less than a few tenths, and may well be significantly more distant.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 2; p. 561-566
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  • 39
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    The local metallicity-surface brightness relationship in galactic disks (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present the results of a first attempt to employ multiaperture masks to obtain spectrophotometry of H II regions in nearby galaxies. A total of 97 H II regions in six southern spiral galaxies were observed using a combination of multiaperture masks and conventional long-slit spectrophotometry. The oxygen abundances derived from the multiaperture mask observations using the empirical abundance diagnostic R(sub 23) are shown to be consistent with those from long-slit spectra and generally show better reproducibility and object definition. Although the number of objects that can be observed simultaneously with this particular system is still quite limited compared with either imaging spectrophotometry or fiber-fed spectrographs, the spectral resolution offered and high throughput in the blue help make multiaperture spectrophotometry a competitive technique for increasing the sampling of H II regions in both radial distance and luminosity. There is still no clear trend of abundance gradient with either the galaxy's luminosity or its Hubble type, although the extrapolated central abundance does appear to correlate with galaxy luminosity/mass. In order to avoid difficulty in choosing an appropriate normalizing radius, we instead plot the oxygen abundance against the underlying I-band surface brightness at the radial distance of the H II region and confirm the existence of a local metallicity-surface brightness reltaionship within the disks of spiral galaxies. Although the simple closed-boc model of galaxy evolution predicts almost the right form of this relationship, a more realistic multizone model employing expnentially decreasing gas infall provides a more satisfactory fit to the observational data, provided the expected enriched gas return from dying low-mass stars shedding their envelopes at late epochs is properly taken into account. This same model, with a star formation law based upon self-regulating star formation in a three-dimensional disk (Dopita & Ryder 1994), is equally capable of accounting for the observed relationship between recent massive star formation and stellar surface brightness (Ryder & Dopita 1994).
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 2; p. 610-631
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  • 40
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    An intercomparison of plasma turbulence at three comets: Grigg-Skjellerup, Giacobini-Zinner, and Halley (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The power laws are approximately f(exp -1.9), f(exp -1.9), and f(exp -2.1) respectively for the Grigg-Shjellerup (GS), Giacobini-Zinner (GZ), and Halley (H) comets. Other than similarities in the power spectra, the magnetic field turbulence is considerably different at the three comets. Phase steepening is demonstrated to occur at the trailing edges of the GS waves. This is probably due to nonlinear steepening plus dispersion of the left-hand mode components, i.e., the turbulence is whistler-mode. This too can be explained by nonlinear steepening plus dispersion of the magnetosonic waves. At the level of GS and GZ turbulence development when the spacecraft measurements were made, classical three-wave processes, such as the decay or modulation instabilities do not appear to play important roles. It is most likely that the nonlinear steepening and dispersive time scales are more rapid than three-wave processes, and the latter had not had time to develop for the relatively new turbulence. The wave turbulence at Halley is linearly polarized. The exact nature of this turbulence is still not well understood. Several possibilities are suggested, based on a preliminary analyses.
    Keywords: ASTROPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 9; p. 1149-1152
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  • 41
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    The unusual morphology of molecular hydrogen emission in the planetary nebula J900 (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report new high-resolution near-infrared imaging observations of the planetary nebula J900, in broadband J, H, and K, and narrowband 2.122 micrometers (for H2 1-0 S(1)), Brackett-gamma, and continuum filters. The H2 images reveal a remarkable set of outward-extending features not detected in any previous observations of theis object. In the northwest lobe of the inner bipolar region, the H2 emission, Brackett-gamma emission, and underlying continuum are spatially resolved. The relative positions of the peaks of the line emission suggest an ionization front seen edge-on. The continuum emission, apparently located nearer to the central star, is likely due to transiently heated small dust grains. The extended H2 emission features are probably excited either by oblique shocks caused by material ejected from the nebula, or by radiation leaking from holes in the opacity surrounding the ionized shell.
    Keywords: ASTRONOMY
    Type: Astronomical Journal (ISSN 0004-6256); 109; 3; p. 1173-1180
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  • 42
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    A study of coronal X-ray emission from short-period Algol binaries (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A study of X-ray emission from five short-period Algol-type binaries based on observations with Advanced Satellite for Cosmology and Astrophysics (ASCA) and ROSAT is presented. We have observed RZ Cas with both satellites, and beta Per, U Cep, delta Lib, and TW Dra with ROSAT. Significant intensity variations are seen in the X-ray emission from RZ Cas, U Cep, TW Dra, and delta Lib. These variations seem unrelated to the eclipsing behavior of these systems and are probably due to either rotational modulation of compact active regions on the surfaces of the chromospherically active secondary components or to flaring activity in the systems. The spectra of all but one of the systems require the presence of at least two discrete plasma components with different temperatures (0.6 - 0.7 keV, and approximately 2 keV) and the abundances of the medium-Z elements 20% - 50% of the solar photospheric values. The high resolving power and signal-to-noise ratio of the ASCA spectra allow us to individually constrain the coronal abundances of O, Ne, Mg, Si, S, and Fe in RZ Cas. We demonstrate that, if we use the elemental abundances and temperatures obtained from the analysis of their ASCA spectra as (fixed) inputs, to fit the ROSAT PSPC spectra well requires the presence of a third component (kT approximately 0.2 - 0.3 keV) in RZ Cas and beta Per. A continuous emission measure model of the power-law type (EM(T) variesas (T/T(sub max)(sup alpha)) generally gives a poor fit to the ASCA and ROSAT data on most sources. Circumstellar or circumbinary absorbing matter seems to be present in some of these systems, as indicated by the variable total column density needed to fit their X-ray spectra.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 2; p. 840-854
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    First detection of x-ray variability of eta carinae (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Recent ROSAT Position Sensitive Proportional Counter (PSPC) observations for the first time unequivocally reveal the presence of a compact source of hard X-ray emission centered on the peculiar star eta Car. These observations also show a dramatic change in the hard-band (E greater than 1.6 keV) counting rate by about a factor of 2 in a 4 month interval. Thus, strong variability, which is a characteristic of eta Car in radio through IR and visible-band wavelengths, is also observed at X-ray energies. The increase in hard X-ray emission could be the result of a tripling of the mass-loss rate in less than 4 months.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 445; 2; p. L21-L24
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  • 44
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    RX J0045.4+4154: A recurrent supersoft x-ray transient in M31 (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Using data extracted from the ROSAT archive we have discovered a recurrent supersoft X-ray transient RX J0045.4+4154 in M31. The first outburst began on 1992 February 2 and continued for at least 4 days, until the end of the observation sequence. A second outburst that lasted more than 6 days was seen to begin on 1993 January 7. The X-ray spectrum on both occasions yields a characteristic blackbody temperature of approximately 90 eV. For a range of plausible continuum models, the hydrogen column density is (0.8-1.5) x 10(exp 21)/sq cm and is consistent with the source being located in M31. This implies an unabsorbed 0.1-2.0 keV peak luminosity of approximately 10(exp 38) ergs/sec. This is the first recurrent X-ray transient to be found in M31 and is particularly notable because it is much softer than the bright X-ray transients seen in our Galaxy. The spectrum is characteristic of the supersoft class of X-ray sources, which are thought to be accreting white dwarfs that have a hydrogen-burning surface layer. A fit to a white dwarf model atmosphere gives a temperature of 10(exp 6)K, the hottest found so far. This high temperature is consistent with a white dwarf mass of 1.3-1.4 solar mass, approaching the Chandrasekhar limit, and burning close to the nuclear stability limit.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 445; 2; p. L25-L28
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  • 45
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    America's foremost early astronomer (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The life of 18th century astronomer, craftsman, and partriot David Rittenhouse is detailed. As a craftsman, he distinguished himself as one of the foremost builders of clocks. He also built magnetic compasses and surveying instruments. The finest examples of his craftsmanship are considered two orreries, mechanical solar systems. In terms of astronomical observations, his best-known contribution was his observation of the transit of Venus in 1769. Rittenhouse constructed the first diffraction grating. Working as Treasurer of Pennsylvania throughout the Revolution, he became the first director of the Mint in 1792. Astronomical observations in later life included charting the position of Uranus after its discovery.
    Keywords: ASTRONOMY
    Type: Sky & Telescope (ISSN 0037-6604); 89; 5; p. 38-41
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  • 46
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    Mg II h and k profiles in high-liminosity, late-type stars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Using high-resolution spectroscopic data taken with the Goddard High Resolution Spectrographic (GHRS) aboard the Hubble Space Telescope (HST) and with the International Ultraviolet Expolorer (IUE) satellite, we compare the profiles of the Mg II h and k lines seen in stars with spectral types ranging from early K through mid-M and luminosities from giants to supergiants. For all of these stars the lines are broad emission features with a central absorption. When plotted on a velocity scale the absorption features of the h and k lines agree very well in both shape and position, as do the blue wings of the emission component. The red wings of the emission, however, show a pronounced difference, with the k line wing consistently shifted to the red of the h line wing. At present the reason for this discrepancy is unknown, but we suggest several possibilities, including radiative transfer effects and high-speed stellar winds.
    Keywords: ASTRONOMY
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 442; 1; p. 328-336
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  • 47
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    Results from ASCA (1995)
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    Publication Date: 2011-08-24
    Description: The X-ray observatory Advanced Satellite for Cosmology and Astrophysics (ASCA) (Astro-D) was launched in Feb 1993 and is now providing excellent spectro-imaging observations of objects from virtually every astronomical class. This paper reviews the scientific capabilities of ASCA using some of the first results from X-ray binaries, cataclysmic variables, and stars.
    Keywords: ASTRONOMY
    Type: Advances in Space Research (ISSN 0273-1177); 16; 3; p. 29-39
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  • 48
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    Infrared observations of an outburst of small dust grains from the nucleus of Comet P/Halley 1986 III at perihelion (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A close examination of the 0.7- to 23-micron infrared data base acquired by Gehrz and Ney (1992), suggests that the nucleus of Comet P/Halley 1986 III emitted a burst of small dust grains during a 3-day period commencing within hours of perihelion passage on 1986 February 9.46 UT. The outburst was characterized by significant increases in the coma's grain color temperature T(sub obs), temperature excess (superheat: S = T(sub obs)/T(sub BB)), infrared luminosity, albedo, and 10-micron silicate emission feature strength. These changes are all consistent with the sudden ejection from the nucleus of a cloud of grains with radii of approximately 0.5 micron. This outburst may have produced the dust that was responsible for some of the tail streamers photographed on 1986 February 22 UT. The peak of the dust outburst occurred about 3 days before a pronounced increase in the water production rate measured by the Pioneer Venus Orbiter Ultraviolet Spectrometer. We suggest that jets that release large quantities of small particles may be largely responsible for some of the variable infrared behavior that has been reported for P/Halley and other comets during the past two decades. Such jets may also account for some of the differences IR Type I and IR Type II comets.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 129-133
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  • 49
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    A tentative detection of the 183-GHz water vapor line in the martian atmosphere: Constraints upon the H2O abundance and vertical distribution (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The 183-GHz water vapor line was tentatively detected on Mars in January 1991, with the IRAM 30-m millimeter antenna, under extremely dry atmospheric conditions. The measurement refers to the whole disk. The spectral line, although marginally detected, can be fit with a constant H2O mixing ratio of 1.0 x 10(exp -5), which corresponds to a water abundance of 1 pr-microns; in any case, an upper limit of 3 pr-microns is inferred. This value is comparable to the very small abundances measured by Clancy (1992) 5 weeks before our observation and seems to imply both seasonal and long-term variations in the martian water cycle.
    Keywords: ASTROPHYSICS
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 110-118
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  • 50
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    Tidal dissipation in oceans on Titan (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Titan's large free eccentricity results in significant tidal dissipation. This can be used to constrain the existence and depth of hydrocarbon oceans. A hydrodynamical-numerical 2 deg ocean tide model has been constructed to investigate this connection. The model allows some simple land configurations. The results indicate that existence of such an ocean over the age of the solar system is hard to explain, as is the existence of the large eccentricity itself. If such an ocean exists, it is likely to be more than 500 m deep, ignoring the influence of land masses.
    Keywords: ASTROPHYSICS
    Type: Icarus (ISSN 0019-1035); 113; 1; p. 39-56
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    Global stratigraphy of Venus: Analysis of a random sample of thirty-six test areas (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The age relations between 36 impact craters with dark paraboloids and other geologic units and structures at these localities have been studied through photogeologic analysis of Magellan SAR images of the surface of Venus. Geologic settings in all 36 sites, about 1000 x 1000 km each, could be characterized using only 10 different terrain units and six types of structures. Mapping of such units and structures in 36 randomly distributed large regions shows evidence for a distinctive regional and global stratigraphic and geologic sequence. On the basis of this sequence we have developed a model that illustrates several major themes in the history of Venus. Most of the history of Venus (that of its first 80% or so) is not preserved in the surface geomorphological record. The major deformation associated with tessera formation in the period sometime between 0.5-1.0 b.y. ago (Ivanov and Basilevsky, 1993) is the earliest event detected. Our stratigraphic analyses suggest that following tessera formation, extensive volcanic flooding resurfaced at least 85% of the planet in the form of the presently-ridged and fractured plains. Several lines of evidence favor a high flux in the post-tessera period but we have no independent evidence for the absolute duration of ridged plains emplacement. During this time, the net state of stress in the lithosphere apparently changed from extensional to compressional, first in the form of extensive ridge belt development, followed by the formation of extensive wrinkle ridges on the flow units. Subsequently, there occurred local emplacement of smooth and lobate plains units which are presently essentially undeformed. The major events in the latest 10% of the presently preserved history of Venus are continued rifting and some associated volcanism, and the redistribution of eolian material largely derived from impact crater deposits. Detailed geologic mapping and stratigraphic synthesis are necessary to test this sequence and to address many of the outstanding problems raised by this analysis.
    Keywords: ASTRONOMY
    Type: Earth, Moon, and Planets (ISSN 0167-9295); 66; 3; p. 285-336
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  • 52
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    Recent chaqnges in the IUE spectrum of the very young planetary nebula He 3-1357 (=SAO 244567) (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We obtained the first high-dispersion IUE spectrum, and an additional low-dispersion spectrum of the very young planetary nebula He 3-1357 and its central star SDAO 244567. In 1988, it showed a very strong C IV lambda-1549 P Cygni profile which diminished and has disappeared by 1994, but C IV absorptions are seen in a high-resolution spectrum. The electron density from the C III F(lambda 1907)/F(lambda 1909) emission ratio is log N(sub e) = 4.1/cc. The older IUE data were reprocessed, and emission-line fluxes vary greatly for the period 1988-1994. The high-dispersion data show a rich Fe V and Fe VI absorption spectrum.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 443; 1; p. 245-248
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  • 53
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    Precession and nutation from joint analysis of radio interferometric and lunar laser ranging observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: 24 years of Lunar Laser Ranging (LLR) observations and 16 years of Very Long Baseline Interferometry (VLBI) observations are combined in a global analysis to yield improved estimates of the Earth's precession and nutation. The correction to the International Astronomical Union (IAU) (1976) precession constant inferred from this joint VLBI/LLR analysis is -3.00 +/- 0.20 milliarcsec/yr (mas/yr). A significant obliquity rate correction of -0.20 +/- 0.08 mas/yr is also found. In all, 32 forced nutation coefficients are estimated. These coefficients confirm that the IAU (1980) nutation theory is in error by several mas. The estimated nutation coeficients are found to vary by as much as several tenths of mas, depending on the a priori nutation model used to analyze the VLBI and LLR data. Forced circular nutations derived from this analysis agree with the ZMOA-1990-2 nutation theory at the 0.2 mas level for the 18.6 yr terms, and at the 0.05 mas level for the other terms (periods less than or = 1 yr). A retrograde free core nutation with an amplitude of 0.20 mas is also detected. Its phase is found to be very sensitive to the precise value of the free core nutation period used in the solution. Separate analyses of four independent subsets of the LVBI data indicate no significant variations of the free core nutation since 1988. The pre-1988 estimates of the free core nutation are consistent with the post-1988 estimates but are not accurate enough to rule out possible variations of the free core nutation at these earlier epochs.
    Keywords: ASTROPHYSICS
    Type: The Astronomical Journal (ISSN 0004-6256); 109; 1669; p. 418-427
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  • 54
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    Radio properties of narrow-lined Seyfert 1 galaxies (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have observed seven narrow-linedd Seyfert 1 (NLS1) galaxies and one high-ionization Seyfert 2 galaxy with the Very Large Array (VLA). Combining these observations with published data, we summarize the radio properties of the NLS1 galaxies for which spectropolarimetry was reported by Goodrich. Fifteen of these 17 objects now have published radio observations of high sensitivity, and only nine of those have been detected. For a Hubble parameter of 75 km/s/Mpc, the 6 cm radio powers range from 10(exp 20) to 10(exp 23) W/Hz, within the range previously found for other types of Seyfert galaxy. The median radio size of the nine VLA-detected galaxies is no larger than 300 pc, similar to the median size found by Ulvestad & Wilson for a distance-limited sample of Seyfert galaxies. Of the six NLS1 galaxies known to have significant intrinsic optical polarization, three have measurable radio axes. Two of those three galaxies have radio major axes close to 90 deg from their polarization position angles, while the third has an inner radio axis that may be nearly parallel to the polarization position angle. The former relationship is expected for a Seyfert 1 in a unified model of Seyfert galaxies, assuming no intrinsic continuum polarization.
    Keywords: ASTRONOMY
    Type: The Astronomical Journal (ISSN 0004-6256); 109; 1669; p. 81-86
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    Ulysses magnetic field observations of fluctuations within polar coronal flows (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Ulysses spacecraft has gathered data from within flows from the Sun's southern polar coronal hole, the first in situ measurement of this region. We present a brief analysis of the heliospheric magnetic field data from this region, using a fractal method. As is the case near the ecliptic, estimated spectral exponents are near 5/3 on spacecraft scales of seconds to minutes. On longer time scales, however, there appears to be a significantly different population in polar flows, which is similar to that found by the Helios spacecraft in fast solar wind flows at 0.3 AU.
    Keywords: ASTROPHYSICS
    Type: Annales Geophysicae (ISSN 0992-7689); 13; 1; p. 105-107
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    The magnetic field in LYNDS 1457: Multiband photopolarimetry (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have performed multiband photopolarimetry toward stars behind the molecular cloud L1457 (MBM 12). This cloud is the nearest known molecular cloud (65 pc) and thought to be contained within the local 'hot bubble.' The polarization shows a regular structure, indicating that the cloud is threaded by an ordered magnetic field. The wavelength dependence of the polarization seems to indicate that the grains in L1457 have higher indices of refraction than normal for interstellar clouds. However, the wavelength of maximum polarization indicates that their size distribution is close to normal.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 443; 1; p. L49-L52
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  • 57
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    Topography of closed depressions, scarps, and grabens in the north Tharsis region of Mars: Implications for shallow crustal discontinuities and Graben formation (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Using Viking Orbiter images, detailed photoclinometric profiles were obtained across 10 irregular depressions, 32 fretted fractures, 40 troughs and pits, 124 solitary scarps, and 370 simple grabens in the north Tharsis region of Mars. These data allow inferences to be made on the shallow crustal structure of this region. The frequency modes of measured scarp heights correspond with previous general thickness estimates of the heavily cratered and rigded plains units. The depths of the flat-floored irregular depressions (55-175 m), fretted fractures (85-890 m), and troughs and pits (60-1620 m) are also similar to scarp heights (thicknesses) of the geologic units in which these depressions occur, which suggests that the depths of these flat-floored features were controlled by erosional base levels created by lithologic contacts. Although the features have a similar age, both their depths and their observed local structural control increase in the order listed above, which suggests that the more advanced stages of associated fracturing facilitated the development of these depressions by increasing permeability. If a ground-ice zone is a factor in development of these features, as has been suggested, our observation that the depths of these features decrease with increasing latitude suggests that either the thickness of the ground-ice zone does not increase poleward or the depths of the depressions were controlled by the top of the ground-ice zone whose depth may decrease with latitude.
    Keywords: ASTRONOMY
    Type: Icarus (ISSN 0019-1035); 114; 2; p. 403-422
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    The neutral oxygen spectrum. 2: Pumping by hydrogen Lyman-beta under the optically thin condition: A first application to the classical novae (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A calculation, employing a detailed model of neutral oxygen, is carried out to give fluorescent line intensities expected in a long-proposed photoexcitation by accidental resonance (PAR) process in which hydrogen Lyman-beta photoexcites the oxygen spectrum. The results pertain to the optically thin case but provide an upper limit to the fluorescent intensities which can be attained. They are applied to analyze line ratios involving the strong 8446 A line observed in classical novae during the diffusion-enhanced and Orion phases. Operation of the PAR process in the novae is verified. It is found that photoexcitation rates in the ejecta reach values greater than 0.1/sec, corresponding to hydrogen Lyman-beta radiation field intensities greater than 1250 ergs/cm/sec/sr.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 1; p. 346-356
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  • 59
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    Evidence for chemical processing of precometary icy grains in circumstellar environments of pre-main-sequence stars (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report the detection of a broad absorption feature near 2166/cm in the spectrum of the Taurus cloud cource Elias 18. This pre-main-sequence source is the second in Taurus, the third in our survey, and the fifth known in the sky to show the broad 2166/cm absorption feature. Of equal importance, this feature is not seen toward several other embedded sources in our survey, nor is it seen toward the source Elias 16, located behind the Taurus cloud. Laboratory experiments with interstellar ice analogs show that such a feature is associated with a complex C triple bonded to N containing compound (called X(C triple bonded to N)) that results from high-energy processing (ultraviolet irradiation or ion bombardment) of simple ice components into more complex, organic components. We find a nonlinear anticorrelation between the abundance of X(C triple bonded to N) and frozen CO components in nonpolar lattices. We find no correlation between the abundance of X(C triple bonded to N) and frozen CO in polar lattices. Because the abundances of frozen CO and H2O are strongly correlated with each other and with visual extinction toward sources embedded in and located behind the Taurus molecular cloud, these ice components usually are associated with intracloud material. Our results indicate that X(C triple bonded to N) molecules result from chemical processing of dust grains dominated by nonpolar icy mantles in the local environments of pre-main-sequence stars. Such processing of icy grains in the early solar system may be an important source of organic compounds observed in minor solar system bodies. The delivery of these organic compounds to the surface of the primitive Earth through comet impacts may have provided the raw materials for prebiotic chemistry.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 1; p. 279-287
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    Physical properties of the OMC-2 and OMC-3 cores from CS and C(18)O observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have investigated the properties of the OMC-2 and OMC-3 cores in the Orion giant molecular cloud using high spatial spectral resolution observations of several transitions of the (13)CO, C(18)O, C(S-32) and C(S-34) molecules taken with the SEST telescope. The OMC-2 core consists of one clump (22 solar mass) with a radius of 0.11 pc surrounded by a cluster of 11 discrete infrared sources. The H2 column density and volume density in the center of this clump are 2 x 10(exp 22)/sq cm and 9 x 10(exp 5)/cu cm respectively. From a comparison between physical parameters derived from C(18)O and C(S-32) observations we conclude that the molecular envelope around the core has been completely removed by these sources and that only the very dense gas is left. OMC-3 shows a more complex elongated structure in C(18)O and CS than OMC-2. The C(S-32) and C(S-34) maps show that the denser region can be separated into at least sub-cores of roughly equal sizes (radius approximately equals 0.13 pc), with n(H2) = 6 x 10(exp 5)/cu cm, and a mass of 10 solar mass (from C(S-32)). The very different masses obtained for the central core from C(18)O and C(S-32) (55 and 12 solar mass respectively) indicate that a massive envelope is still present around the very dense sub-cores. We report the first detection of several molecular outflows in OMC-3. The presence of an IRAS source and the first detection of these outflows confirm that star formation is going on in OMC-3. Based on the different physical properties of these regions compared with OMC-1, OMC-2 appears to be in an intermediate evolutionary stage between OMC-1 and OMC-3.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 294; 3; p. 835-854
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    N IV emission lines in the ultraviolet spectra of gaseous nebulae (1995)
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    Publication Date: 2011-08-24
    Description: Theoretical electron density sensitive emission-line ratios, determined using electron impact excitation rates calculated with the R-matrix code, are presented for R = I(2s(sup 2) (1)S-2s2p 3P(sub 2))/I(2s(sup 2) (1)S-2s2p 3P(sub 1) = 1(1483 A)/I(1486 A) in N IV. These are found to be up to an order of magnitude different from those deduced by previous authors, principally due to the inclusion of excitation rates for transitions among the 2s2p (3)p fine-structure levels. The observed values of R for several planetary nebulae, symbiotic stars and the Cygnus Loop supernova remnant, measured from spectra obtained with the International Ultraviolet Explorer (IUE) satellite and the Hopkins Ultraviolet Explorer (HUT), lead to electron densities which are in excellent agreement with those deduced from line ratios in other species. This provides observational support for the accuracy of the atomic data adopted in the present calculations.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 1; p. 500-503
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    Grains in ionized nebulae: Spectral line diagnostics (1995)
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    Publication Date: 2011-08-24
    Description: The depletion of condensable elements onto grains in gaseous nebulae can provide evidence that dust is well mixed with the ionized gas. Al and CA are two of the most depleted elements in the general interstellar medium, and it is therefore important to measure their abundances within the ionized region of nebulae. We compute a large grid of photoionization models and identify sets of line ratios which are relatively insensitive to stellar and nebular parameters, and are thus excellent diagnostics for determining relative abundances. Based on the absence of the ((Ca II) lambda lambda 291, 7324 doublet and the detection of Al II) lambda lambda 2660, 2669 in the ultraviolet, we determine the extent of aluminum and calcium depletion onto grains in NGC 7027 and the Orion Nebula. Our results show a approximately 0.3 dex depletion for Al, but a depletion of more than two and a half orders of magnitude for Ca. A similar calculation based on Mg II lambda 2798 yields roughly a 0.8 dex depletion for Mg. This reaffirms the discrepancy between depletion determined from high and low ionization Mg lines. We also find evidence for a 'depletion gradient' in Ca in NGC 7027, since the calcium depletion we infer for the outer, more neutral regions using (Ca II) is somewhat higher than that inferred for the inner high-ionization region, using (Ca v). This gradient can test current models of the survival of grains within hot ionized gas.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 793-799
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    The X-ray telescope on board ASCA (1995)
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    Publication Date: 2011-08-24
    Description: The Advanced Satellite for Cosmology and Astrophysics (ASCA) instrument uses identical conical foil X-ray mirrors for its four telescopes. One of the major advantages of ASCA's telescopes is the first time ever use of X-ray imaging over a broad energy band and high throughput for conducting astronomical spectroscopy. Nested thin foil reflectors make possible a large effective area up to 10 keV, even under the tight weight restriction of the ASCA spacecraft. The expected characteristics of the ASCA mirrors are summarized based on ray tracings and pre-flight calibrations. The total effective area of four telescopes at 1 and 7 keV are approximately 1200 and 600 sq cm, respectively. The image size (half power diameter: HPD) is about 3 min. The field of view is 24 min and 16 min full width at half maximum for 1 and 7 keV, respectively. Observations of several X-ray sources from space during the performance verification phase have confirmed those performances as well as the alignment of the optical systems.
    Keywords: ASTRONOMY
    Type: PASJ: Publications of the Astronomical Society of Japan (ISSN 0004-6264); 47; 1; p. 105-114
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    On the nature of the binary radio pulsar PSR B0042-73 in the small magellanic cloud (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The modern scenario of evolution of massive binary systems predicts the existence of a subclass of binary radio pulsars (PSRs) with black holes (BHs). Their Galactic number was evaluated as approximately 1 per 1000 single pulsars (Lipunov et al. 1994b). Distinctive properties of such binaries would be (1) mass of the unseen companion M(sub c) greater than 3-4 solar mass and (2) absence of eclipses of the pulsar radiation with no distinctive variance of the dispersion measure along the pulsar orbit. The pulsars themselves must be similar to standard isolated ones. The recently discovered binary 1 s pulsar PSR B0042-73 = PSR J0045-7319 in the Small Magellanic Cloud (SMC) with a massive companion in a highly elongated (eccentricity e =0.8) 51 day orbit (Kaspi et al. 1994) may be the first such pulsar with a BH. The paradoxical fact that the first pulsar discovered in the SMC proved to be in a binary system can be naturally understood if its companion actually is a 10-30 solar mass black hole. We illustrate this fact by the numerical calculation of evolution of radio pulsars after a star formation burst.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 776-778
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    Optically thin accretion disks in the Kerr metric (1995)
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    Publication Date: 2011-08-24
    Description: We calculate the structure of an effectively optically thin and geometrically thin accretion disk in the Kerr geometry, including electron-positron pairs. We show that the properties of the disk solutions are strongly dependent on the angular momentum of the central black hole. We find that close to a rapidly rotating hole there can be an appreciable pair density even for modest accretion rates. Pair critical accretion rates recently discovered in Newtonian disk models are also shown to be present in the general relativistic models, and we show that the geometrically thin disk approximations easily break down for rapidly rotating holes.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 765-769
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    Relativistic hadrons and the origin of relativistic outflows in active galactic nuclei (1995)
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    Publication Date: 2011-08-24
    Description: We examine the hydrodynamic origin of relativistic outflows in active galactic nuclei (AGN). Specifically, we propose that the presence of a population of relativistic hadrons in the AGN 'central engine' and the associated neutron production suffices to produce outflows which under rather general conditions could be relativistic. The main such condition is that the size of the neutron production region be larger than the neutron flight path tau(sub n) approximately 3 x 10(exp 13) cm. This condition guarantees that the mean energy per particle in the proton fluid, resulting from the decay of the neutrons outside their production region, be greater than the proton rest mass. The expansion of this fluid can then lead naturally to a relativistic outflow by conversion of its internal energy to directed motion. We follow the development of such flows by solving the mass, energy as well as the kinetic equation for the proton gas in steady state, taking into account the source terms due to compute accurately the adiabatic index of the expanding gas, and in conjunction with Bernoulli's equation the detailed evolution of the bulk Lorentz factor. We further examine the role of large-scale magnetic fields in confining these outflows to produce the jets observed at larger scales.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 2; p. 521-532
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    Flow downstream of the heliospheric terminal shock: Magnetic field line topology and solar cycle imprint (1995)
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    Publication Date: 2011-08-24
    Description: The topology of the magnetic field in the heliosheath is illustrated using plots of the field lines. It is shown that the Archimedean spiral inside the terminal shock is rotated back in the heliosheath into nested spirals that are advected in the direction of the interstellar wind. The 22-year solar magnetic cycle is imprinted onto these field lines in the form of unipolar magnetic envelopes surrounded by volumes of strongly mixed polarity. Each envelope is defined by the changing tilt of the heliospheric current sheet, which is in turn defined by the boundary of unipolar high-latitude regions on the Sun that shrink to the pole at solar maximum and expand to the equator at solar minimum. The detailed shape of the envelopes is regulated by the solar wind velocity structure in the heliosheath.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A3; p. 3463-3471
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    Near- and far-infrared observations of interplanetary dust bands from the COBE diffuse infrared background experiment (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Data from the Diffuse Infrared Background Experiment (DIRBE) instrument aboard the Cosmic Background Explorer Satellite (COBE) spacecraft have been used to examine the near and far infrared signatures of the interplanetary dust (IPD) bands. Images of the dust band pairs at ecliptic latitudes of +/- 1.4 deg and +/- 10 deg have been produced at DIRBE wavelengths from 1.25 to 100 micrometers. The observations at the shorter wavelengths provide the first evidence of scattered sunlight from particles responsible for the dust bands. It is found that the grains in the bands and those in the smooth IPD cloud have similar spectral energy distributions, suggesting similar compositions and possibly a common origin. The scattering albedos from 1.25 to 3.5 micrometers for the grains in the dust bands and those in the IPD cloud are 0.22 and 0.29, respectively. The 10 deg band pair is cooler (185 +/- 10 K) than the smooth interplanetary dust cloud (259 +/- 10 K). From both parallactic and thermal analyses, the implied location of the grains responsible for the peak brightness of the 10 deg band pair is 2.1 +/- 0.1 AU the Sun A parallactic distance of 1.4 +/- 0.2 AU is found for the peak of the 1.4 deg band pair.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal (ISSN 0004-637X); 442; 2, Pa; p. 662-667
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    Elliptically polarized bursty radio emissions from Jupiter (1995)
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    Publication Date: 2011-08-24
    Description: We report a new component of Jovian radio emission observed by the Ulysses spacecraft when Ulysses was at high Jovigraphic latitudes (greater than or approximately = 30 deg north or south of the Jovian magnetic equator). This bursty high-latitude emission is elliptically polarized in the right-hand sense when observed from northern latitudes and in the left-hand sense when observed from southern latitudes, consistent with extraordinary mode. The orientation of the polarization ellipse is observed to systematically vary with time relative to the observer. It is argued that the elliptically-polarized nature of the emission is intrinsic to the source region.
    Keywords: ASTRONOMY
    Type: Geophysical Research Letters (ISSN 0094-8276); 22; 4; p. 345-348
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    Balloon-borne measurements of the SN 1987A hard X-ray continuum (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: SN 1987A hard X-ray continuum spectra obtained on 1987 October 29, 1988 April 9-10, and 1988 November 11 from balloon-flight measurments are presented. The spectra, spanning the energy range from 25 keV to 300 keV, have been analyzed using a detector response matrix inversion technique that converts the spectra form counts/s/sq cm keV to photons/s/sq cm keV allowing direct comparison with theoretical models. The results indicate that the bulk of the (56)Co is mixed moderately through the inner regions of the supernova envelope but they do not preclude the mixing of a small amount of the (56)Co farther out into the envelope necessary to account for the observed (56)Co line fluxes. The effect of the ratio (57)Co to (56)Co on the 1988 November 11 continuum spectrum is discussed.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 963-975
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    The ultraviolet spectrum of the gravitational lens candidate UM 425 = QSO 1120+019: Evidence for broad absorption line (BAL) structure (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The UV line profile structure of high-ionization resonance lines found with the International Ultraviolet Explorer (IUE) in the brightest of four multiply imaged sources (images-A) in the candidate gravitational lens UM 425 = QSO 1120+019 indicates broad absorption line (BAL) structure. The deep-broad trough associated with the O IV line extends to velocities approiximately -12,000 km/s, and contains disrete features that suggest multicomponent velocity structure. This structure may include contributions from C IV absorption from the early-type galaxy that is believed to lens UM 425. A strong absorption feature in the blue wing of the Lyman-alpha lambda 1216 emission line may be a Lyman alpha absorption system at a Z(sub Ly alpha) = 1.437 +/- 0.003, or it may be formed by the superposition of the broad N V lambda lambda 1238, 1242 absorption trough on the extended blue emission wing of the QSO Lyman-alpha line. We obtained a redshift of Z(sub QSO) = 1.471 +/- 0.003 from Lyman-alpha lambda 1215, consistent with the redshift found by Meylan and Djorgovski in the optical. The Lyman-alpha line appears unusally weak due to the presence of N V lambda 1240 BAL absorption. A Lyman-limit absorption system at lambda 912 was not observed in the QSO rest frame. The detection of BAL structure in the other weaker ground-state resonance lines of N II (l) and S IV (l) was not found, suggesting these lines are formed in a region that is distinct from the BAL component. Detection of BAL structure in the other fainter images in this system with Hubble Space Telescope (HST) instrumentation, similar to structure observed here in image A, could provide evidence that UM 425 is a gravitational lens.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 439; 2; p. 599-603
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    Heating and ionization of stellar chromospheres by nonthermal proton beams: Implications for impulsive phase, redshifted Lyman-alpha radiation in stellar flares (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We investigate the physical basis for the timescale of impulsive-phase, redshifted Lyman-alpha emission in stellar flares on the assumption that it is determined by energy losses in a nonthermal proton beam that is penetrating the chromosphere from above. The temporal evolution of ionization and heating in representative model chromospheres subjected to such beams is calculated. The treatment of 'stopping' of beam protons takes into account their interactions with (1) electrons bound in neutral hydrogen, (2) nuclei of neutral hydrogen, (3) free electrons, and (4) ambient thermal protons. We find that, for constant incident beam flux, the system attains an equilibrium with the beam energy input to the chromosphere balanced by radiative losses. In equilibrium, the beam penetration depth is constant, and erosion of the chromosphere ceases. If the redshifted, impulsive-phase stellar flare Lyman-alpha emission is produced by downstreaming hydrogen formed through charge exchange between beam protons and ambient hydrogen, then the emission should end when the beam no longer reaches neutral hydrogen. The durations of representative emission events calculated on this assumption range from 0.1 to 14 s. The stronger the beam, the shorter the timescale over which the redshifted Lyman-alpha emission can be observed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 1; p. 385-399
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    EGRET observations of gamma-ray emission from the interstellar gas in Orion (1995)
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    Publication Date: 2011-08-24
    Description: The high-energy diffuse gamma-ray emission from the interstellar gas in Orion was studied using observations from the Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Gamma-Ray Observatory (CGRO) and radio surveys of the H I and CO emission. The good correlation of the gamma-ray emission with the atomic and molecular gas permits determination of the gamma-ray emissivity per nucleon in the interstellar medium and the molecular mass calibrating ratio N(H2)/W(sub co) in Orion. The integral gamma-ray emissivity is (1.7 +/- 0.1) x 10(exp -26)/s/sr for E greater than 100 MeV, in good agreement with expectations from studies of the diffuse emission on larger scales. The N(H2)/W(sub co) ratio is (1.06 +/- 0.14) x 10(exp 20)/sq cm/(K km/s), approximately 40% less than the commonly adopted Galactic average. We find no evidence for variations of the cosmic-ray density or N(H2)/W(sub co) ratio in Orion at the sensitivity and resolution of EGRET.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 1; p. 270-280
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    The megaparsec-scale environments of BL Lacertae objects (1995)
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    Publication Date: 2011-08-24
    Description: We compare observations of BL Lac megaparsec-scale clustering environments with those for F-R I radio galaxies V and R image data are used to show that the strengths of the clustering measured via spatial cross-correlation amplitude are similar for the two types of galaxies and are consistent with Abel richness class 0. We discuss the implications this has for the origin of the BL Lac phenomena. We also examine the evolution of clustering environments of F-R I radio galaxies and BL Lac objects with redshift.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 441; 1; p. 113-119
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    Ultraluminous infrared galaxies and the radio-optical correlation for quasars (1995)
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    Publication Date: 2011-08-24
    Description: Through analysis of available optical spectrophotometric data and radio flux density measurements in the literature, it is demonstrated that a good correlation exists between the radio power and bolometric luminosity of the optically-selected OSOs in the Bright Quasar Sample (BOS) of Schmidt and Green (1983). We have recently used VLBI measurements of a sample of ultraluminous infrared galaxies to infer the likely existence of radio-quiet Active Galactic Nuclei (AGNs) deeply enshrouded in dust within their nuclei (Lonsdale, Smith, and Lonsdale 1993). We employ the radio-bolometric luminosity correlation for the BQS quasars to test whether these hypothetical buried AGNs can be energetically responsible for the observed far-infrared luminosities of the ultraluminous infrared galaxies. The ultraluminous infrared galaxies are shown to follow the same relation between radio core power and bolometric luminosity as the radio-quiet QSOs, suggesting that buried AGNs can account for essentially all the observed infrared luminosity, and raising the possibility that any starburst which may be in progress may not be energetically dominant. The broader implications of the radio-optical correlation in quasars for AGNs and luminous infrared galaxy models and the use of radio astronomy as a probe of the central powerhouse in radio quiet AGNs and luminous infrared galaxies are briefly discussed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 438; 2; p. 623-642
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    A Fizeau optical interferometer astrometric satellite (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The proposed design and construction of the Fizeau astrometric mapping explorer (FAME), a small astrometric instrument for use on an artificial satellite, is reported on. The instrument and spacecraft are designed to slowly spin and will repeatedly scan great circles on the sky so that, over a period of time, it will cover the complete sky and repeat in a manner similar to that of the Hipparcos satellite. The instrument will use the two fixed dilute aperture telescopes to measure a fixed angle between stars and detect the positions, magnitude and color of all stars crossing its field of view to a visual magnitude of approximately 15 mag. The aim of the instrument is to obtain a catalog of positions, proper motions and parallaxes of all stars down to about 15 mag, with a magnitude dependent accuracy of positions of 20 to 800 micro arcsec, proper motions of 20 to 800 micro arcsec per year and parallaxes of 20 to 800 micro arcsec.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 187-189
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    Analysis of an astrometric Fizeau interferometer for GAIA (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The concepts related to the operation and design of the global astrometric interferometer for astrophysics (GAIA) bring together solutions chosen for the astrometry satellite and interferometric techniques. Like the Hipparcos satellite, GAIA is a continuously scanning instrument for which the integration time on any observed object is limited by the field of view of the detector. If a final astrometric accuracy of 10 microarcsec is aimed at, a field of 1 deg in diameter is needed. A design is presented for the proposed 2.6 m baseline Fizeau interferometer with two 40 cm apertures and overall dimensions compatible with the size of the Ariane 5 payload shroud. It has a 0.9 deg diffraction limited field of view. The response of the optical system to small perturbations on each optical element is given in terms of the fringe visibility, which is shown to be dependent on the sub-aperture spot separation. The robustness of the design to thermal, mechanical and manufacturing errors is discussed. The unavoidable distortion present in wide field optical systems is analyzed in terms of displacement of the interference fringes.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 241-249
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    Linking GAIA proper motions to the extragalactic reference system by QSO observations (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: A direct link to an extragalactic reference system is considered as being a principle aim of the global astrometric interferometer for astrophysics (GAIA) mission. The data available from an extragalactic data base and a quasi stellar object (QSO) catalog were used to obtain an estimation of the number of QSO link candidates. The quality of presently available data and the expected accuracy of the extragalactic link are discussed. It is concluded that at least 150 QSO's must be observed by GAIA in order to guarantee an accuracy of better than 1 microarcsec/year for the link. New observations will be needed before the GAIA launch in order to reduce uncertainties in the positions, magnitudes and redshifts for some known quasars. The variability of QSO's with magnitudes near the GAIA observation limit can raise a potential problem. The motions of nearby QSO's are expected to be much smaller than 2 microarcsec/year, and therefore, will not affect the accuracy of the link in the proposed GAIA mission.
    Keywords: ASTROPHYSICS
    Type: ESA, Future Possibilities for Astrometry in Space; p 127-129
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    Moderate-resolution spectral standards from lambda 5600 to lambda 9000 (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We present a grid of stellar classification spectra of moderate resolution (R approximately 1500) in the range lambda lambda 5600-9000 A, compiled from high signal-to noise spectra of 275 stars, most in the open clusters Praesepe and M67. The grid covers dwarfs from types B8 through M5, giants from G8 through M7, and subgiants from F5 through K0. We catalog atomic and molecular absorption features useful for stellar classification, and demonstrate the use of luminosity-sensitive features to distinguish between late-type dwarf and giant stars. The entire database is made available in digital format on anonymous ftp and through the World Wide Web.
    Keywords: ASTRONOMY
    Type: Astronomical Journal (ISSN 0004-6256); 109; 3; p. 1379-1390
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    Meteor stream activity. 2: Meteor outbursts (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: In the past two centuries, alert amateur and professional meteor astronomers have documented 35 outbursts of 17 individual meteor streams well enough to allow the construction of a homogeneous set of activity curves. These curves add to similar profiles of the annual streams in a previous paper (Paper 1). This paper attempts to define the type and range of phenomena that classify as meteor outbursts from which the following is concluded: Outbursts are associated with the return of the comet to perihelion (near-comet type outbursts), but occur also when the parent comet is far from perihelion and far from the Earth (far-comet type). All outbursts of a given type only, depending on encounter geometry. The activity curves, expressed in terms of Zenith Hourly Rates (ZHR), have a shape that is generally well described by: ZHR = ZHR(sub max) 10(sup(-B (the absolute value of lambda (sub dot in a circle) - lambda (sup max) (sub dot in a circle))). The steepness of the slopes varies from an exponent of B = 7 to B = 220 per degree of solar longitude, with a typical value of B = 30. In addition, most near-comet type outbursts have a broader component underlying the main peak with B approximately 1 - 7.The duration Delta t is approximately 1/B of the main peak is almost independent of location near the comet, while the background component varies considerably in duration and relative intensity from one return to another. The two components in the activity curve are due to two distinct structures in the dust distribution near the parent comet, where the main component can be due to a sheet of dust that emanates from the IRAS dust trail. This brings the total number of distinct structures in meteor streams to four, including the two structures from the annual stream activity in Paper 1.
    Keywords: ASTRONOMY
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 295; 1; p. 206-235
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    Transition probabilities for the UV0.01 multiplet in N III (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We report on large-scale ab initio multiconfiguration Hartree-Fock calculations for the UV0.01 multiplet, 2s(sup 2)2p(sup 2)P(sub J) - 2s2p(sup 2 4)P(sub J prime), in N III. The resulting transition probabilities agree very well with recent semiempirical calculations, and the lifetimes for two of the three upper levels agree with experiments. The deviation for the third level is discussed. Comparisons made with the highest quality IUE echelle spectra available -- those of RR Tel and V1016 Cyg (both photoionized sources with electron densities below 10(exp 8)/cu cm) -- show that computed branching ratios of lines sharing a common upper level are in agreement with observations to within uncertainties of +/- 10%. High-quality solar limb data or stellar data from the Hubble Space Telescope (HST) could, in principle, be used to determine whether the theoretical or measured lifetimes for the discrepant level are in error. Unfortunately, stellar data for high-density plasmas (N(sub e) greater than 10(exp 11)/cu cm are needed) do not yet exist, and existing solar data lack the photometric precision to address this problem.
    Keywords: ASTROPHYSICS
    Type: The Astrophysical Journal, Part 1 (ISSN 0004-637X); 445; 1; p. 457-464
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    Asteroid orbit evolution due to thermal drag (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Thermal drag, a variant of the Yarkovsky effect, may act on small asteroids with sizes from a few meters to a few tens of meters. Yarkovsky thermal drag comes from an asteroid's absorbing sunlight in the visible and reradiating it in the infrared. Since the infrared photons have momentum, by action-reaction, they kick the asteroid when they leave its surface. The reradiation, which is asymmetric in latitude over the asteroid, gives a net force along the asteroid's pole. Due to the asteroid's thermal inertia, averaging this force over one orbital period produces a net drag if the spin axis has a component in the orbital plane. Thermal drag tends to circularize orbits. It can increase or decrease orbital inclinations. An object whose spin axis points in random directions over its lifetime displays little change in orbital inclination. Thermal drag appears to have little to do with the delivery of chondrites from the asteroid belt; the thermal drag timescale (10(exp 8) years for meter-sizzed objects) is long compared with their cosmic ray exposure ages, and aphelia in the asteroid belt are not expected for mature thermal drag orbits. However, Yarkovsky thermal drag may act on the recently discovered near-Earth asteroids, which have radii of 10-30 m. Asteroid 1992 DA, for instance, might have its orbit shrunk by 0.1 AU in 3 x 10(exp 7) years, removing it from an Earth-crossing orbit. The near-Earth asteroids also tend to have small to moderate orbital eccentricities, as expected for highly evolved thermal drag objects. However, the time needed to bring them in from the asteroid belt (about 10(exp 9) years) is long compared with the collisonal and dynamical lifetimes (both about 10(exp 8) years) for Earth-crossing objects, arguing against their emplacement by thermal drag.
    Keywords: ASTROPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; E1; p. 1585-1594
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  • 83
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    Simulated cosmic microwave background maps at 0.5 deg resolution: Unresolved features (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: High-contrast peaks in the cosmic microwave background (CMB) anisotropy can appear as unresolved sources to observers. We fit simluated CMB maps generated with a cold dark matter model to a set of unresolved features at instrumental resolution 0.5 deg-1.5 deg to derive the integral number density per steradian n (greater than absolute value of T) of features brighter than threshold temperature absolute value of T and compare the results to recent experiments. A typical medium-scale experiment observing 0.001 sr at 0.5 deg resolution would expect to observe one feature brighter than 85 micro-K after convolution with the beam profile, with less than 5% probability to observe a source brighter than 150 micro-K. Increasing the power-law index of primordial density perturbations n from 1 to 1.5 raises these temperature limits absolute value of T by a factor of 2. The MSAM features are in agreement with standard cold dark matter models and are not necessarily evidence for processes beyond the standard model.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 441; 1; p. L5-L7
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    Simulated cosmic microwave background maps at 0.5 deg resolution: Basic results (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have simulated full-sky maps of the cosmic microwave background (CMB) anisotropy expected from cold dark matter (CDM) models at 0.5 deg and 1.0 deg angular resolution. Statistical properties of the maps are presented as a function of sky coverage, angular resolution, and instrument noise, and the implications of these results for observability of the Doppler peak are discussed. The rms fluctuations in a map are not a particularly robust probe of the existence of a Doppler peak; however, a full correlation analysis can provide reasonable sensitivity. We find that sensitivity to the Doppler peak depends primarily on the fraction of sky covered, and only secondarily on the angular resolution and noise level. Color plates of the simulated maps are presented to illustrate the anisotropies.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 441; 1; p. L1-L4
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    Intense radio outburst from the supermassive star Eta Carinae (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: On five occasions between 1992 June 29 and 1994 May 3, we have used the Australia Telescope Compact Array (ATCA) to image Eta Carinae at a wavelength of 3 cm and a resolution of 1 arcsec. These observations have revealed remarkable activity. Since 1992 June, the total flux density has increase from 0.8 to 2.2 Jy, and the original single compact source has grown to a complex of sources spread over an area of about 16 sq arcsec. Strong hydrogen recombination-line spectral emission has appeared at the site of the strongest of these new sources. This recombination emission has the largest spectral width ever observed from a star, +/- 250 km/s, and reveals gas with turbulent velocities as great as 250 km/s approaching us at an average velocity of about 200 km/s. We believe that this radio outburst has been caused by a more than threefold increase of ultraviolet luminosity, and consequent ionization of previously neutral gas clouds.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 441; 2; p. L73-L76
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    Multifrequency observations of KAZ 102 during the ROSAT all-sky survey (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The bright quasar Kaz 102, which lies in the vicinity of the North Ecliptic Pole, was monitored during the ROSAT All Sky Survey for 121.5 days from 1990 July 30 to 1991 January 25. In the course of the survey, optical photometry with various filters was peformed at several epochs, together with UV (IUE) and optical spectrophotometry. The spectral energy distribution in the 3 x 10(exp 14) -3 x 10(exp 17) Hz range is obtained simultaneously among the various frequencies to less than or = 1 day. No clear case of variability can be made in the X-rays, while in the optical and UV variability of 10%-20% is apparent. An analysis of IUE and Einstein archives indicates a doubling timescale of years for the UV and soft X-ray flux. The X-ray photon index, which in 1979 was rather flat (Gamma = 0.8(+0.6 -0.4), in 1990/1991 was found to be Gamma = 2.22 +/- 0.13, a typical value for radio-quiet quasars in this energy range. The overall energy distribution and the variability are discussed.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal (ISSN 0004-637X); 442; 2, Pa; p. 589-596
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    Calibrating the broad band X-ray telescope (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: This paper describes the calibration of the two solid-state Si(Li) X-ray detectors and the X-ray telescopes that flew as part of Goddard Space Flight Center's Broad Band X-Ray Telescope (BBXRT) experiment on board the space shuttle Columbia in 1990 December. During the 9 day shuttle mission, BBXRT performed approximately 150 observations of 82 celestial sources. The content of the archive is summarized here. Although BBXRT had a relatively short life, it stands as a milestone in X-ray astronomy as being the first instrument to offer moderate spectral resolution over a wide bandpass (0.3-12.0 keV). Among other things, this paper discusses the effective area calibration of the instrument, the flux calibration and flux corrections for off-axis observations, the detector background, and optimal background subtraction techniques. The on-axis effective area calibration for the central detector elements was performed using data from the Crab Nebula, while other carefully selected targets were used for calibration of the outer detector elements. The remaining systematic uncertainties in the effective area calibration for point sources observed both on and off axis are generally less than 5%-10%. The energy scale is known to better than 0.5% at 6.0 keV for both detectors. The results presented here have an impact on the calibration of other medium resolution X-ray experiments such as the CCDs on board ASCA (Astro-D) as well as the Advanced X-Ray Astrophysics Facility detectors.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal Supplement Series (ISSN 0067-0049); 96; 1; p. 303-324
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    Photon-splitting limits to the hardness of emission in strongly magnetized soft gamma repeaters (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Soft gamma repeaters are characterized by recurrent activity consisting of short-duration outbursts of high-energy emission that is typically of temperature less than 40 keV. One recent model of repeaters is that they originate in the environs of neutron stars with superstrong magnetic fields, perhaps greater than 10(exp 14) G. In such fields, the exotic process of magnetic photon splitting gamma yields gamma gamma acts very effectively to reprocess gamma-ray radiation down to hard X-ray energies. In this Letter, the action of photon splitting is considered in some detail, via the solution of photon kinetic equations, determining how it limits the hardness of emission in strongly magnetized repeaters, and thereby obtaining observational constraints to the field in SGR 1806-20.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 440; 2; p. L69-L72
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    Understanding COMPTEL Al-26 1.8 MeV map features (1995)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The COMPTEL sky map of the 1.8 MeV line emission from Al-26 shows an extended diffuse distribution along the Galactic plane with a peculiar large scale asymmetry about the Galactic center (GC) and a clumpy structure with several noticeable hot spots. The most prominent hot spot at the GC appears shifted to positive longitude by about 2 deg. Nearby supernova remnants or Wolf-Rayet stars are plausible explanations for individual hot spots such as in the Vela region. We show that the global asymmetry and most hot spots can be understood by a more general model: the Al-26 sources are confined in the spiral arms of our Galaxy, and coagent star formation is responsible for additional clumpiness. The off-centered GC hot spot is probably due to the observed asymmetrically distributed circumnuclear molecular gas interacting with a central stellar bar, whose existence has been inferred from IR observations.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 440; 2; p. L57-L60
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    The High Resolution Spectrograph for the Space Telescope (1982)
    In:  CASI
    Details
    Publication Date: 2009-11-16
    Description: The High Resoltuion Spectrograph (HRS) in conjunction with the Space Telescope (ST), extends ultraviolet astronomical spectroscopy to higher spectra, spatial, and time resolutions than previously achieved, as well as to fainter and more distant celestial objects. Other significant advances inherent in the instrument are high photometric accuracy and efficient operation via exposure meter control and real time rejection of bad data. These capabilities are provided to accomplish the scientific programs of the HRS investigation definition team, which concern the interstellar medium, stellar winds, and evolutionary aspects of stellar atmosphere studies; the determination of chemical abundances relevant to stellar evolution; the investigation of quasars and Seyfert galaxy nuclei; and the analysis of the atmospheres of solar system objects, including comets.
    Keywords: ASTRONOMY
    Type: Space Telescope Science Inst. The Space Telescope Obs.; p 76-105
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    The PDS-VAX intelligent plate scanning system of Trieste Astronomical Observatory (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: An intelligent subsystem for interfacing a PDS1010A digital microdensitometer to a DEC DR11W DMA 16 bit UNIBUS port in DEC VAX VMS environment was tested. The subsystem employs two MOTOROLA M68000 microprocessors with 128 KB data memory. The PDS primitives and the user defined high level scanning functions and preprocessing modules are loaded from the host computer into two 8 KB RAM memories in the microprocessors using a dedicated PDS control language. The subsystem is planned to employ a nonstandard photomultiplier electronics. Two design schemes were tested: (1) based on three amplifiers of gain 10 cascaded and multiplexed to a 12 bit AD converter, and (2) based on a single amplifier of gain 100 and two 14 bit AD converters.
    Keywords: ASTRONOMY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 175-187
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    Space debris impact experiment (S0001) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The specific objectives of this experiment are to establish the population and size distribution of meteoroids in the mass range from 10 to the minus 10 power to 10 to the minus 4 power G, to establish the current population of man-made debris in the same mass range, and to obtain data on the physical properties (composition and density) of meteoroids.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 136-137
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    Interplanetary dust experiment (A0201) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The objective of this experiment is to study interplanetary dust, variously referred to as cosmic dust, cometary dust, zodiacial dust, or meteoric dust particles. Specific objectives are to obtain information regarding particle mass and velocity, and to undertake correlative analyses with other experiments, both on LDEF or near the time of the LDEF flight.
    Keywords: ASTROPHYSICS
    Type: Long Duration Exposure Facility (LDEF); p 134-135
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    Attempt at dust debris collection with stacked detectors (A0138-2) (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The primary objective of this experiment is to investigate the feasibility of future missions of multilayer thin-film detectors acting as energy sorter to collect micrometeoroids, if not in their original shape, at least as fragments suitable for chemical analysis. It is expected that this kind of particle collector will help in solving one of the most puzzling topics in cosmic-dust studies: the mineralogical and chemical composition of the particles. This is a matter of great interest in the study of the origin and evolution of the solar system.
    Keywords: ASTROPHYSICS
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 124-126
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  • 95
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    Reflections on the Space Telescope (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The significance of the Space Telescope for the advancement of astronomy and astrophysics is described. The current state of knowledge in astronomy and cosmology is summarized and unanswered questions in those fields discussed. The rapid evolution of modern astronomy and the need for systematic observations are stressed.
    Keywords: ASTRONOMY
    Type: Space Telescope Science Inst. The Space Telescope Obs.; p 121-134
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  • 96
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    Astrometric observations with the Space Telescope (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Astrometry with the Space Telescope (ST) is performed using one of the fine guidance sensors (FGS). The FGS, which is based on a pair of Koester's prism interferometers, one for each axis, is capable of measuring the position of one object relative to another with an accuracy of 0.002 arcseconds. Astrometric Data Reduction Software (ADRS) available to the astrometric user of ST is described. The kinds of problems the space telescope astrometry team plans to investigate using ST are discussed.
    Keywords: ASTRONOMY
    Type: Space Telescope Science Inst. The Space Telescope Obs.; p 114-120
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  • 97
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    The wide field/planetary camera (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A wide site of potential astronomical and solar system scientific studies using the wide field planetary camera on space telescope are described. The expected performance of the camera as it approaches final assembly and testing is also detailed.
    Keywords: ASTRONOMY
    Type: Space Telescope Science Inst. The Space Telescope Obs.; p 28-39
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    European astronomy and the Space Telescope: The Space Telescope European Coordinating Facility (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The role of the European Coordinating Facility is described. European participation in the Space Telescope Science Institute and the relation of Space Telescope to ground-based astronomy in Europe are discussed.
    Keywords: ASTRONOMY
    Type: Space Telescope Science Inst. The Space Telescope Obs.; p 16-19
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  • 99
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    Spectroscopy in X-ray astronomy (1981)
    In:  CASI
    Details
    Publication Date: 2006-06-04
    Description: Detailed features in cosmic X-ray sources and their associated temporal variation over a wide energy range were studied. Excess emission and absorption at approximately 6 to 7 kiloelectron volts in the spectra of supernova remnants, binary X-ray sources, and clusters of galaxies were observed. A gas scintillation proportional counter (GSPC) will be used as the detector system. In the gas scintillator the principal limitation is due to the statistics of the initial ionization process only.
    Keywords: ASTRONOMY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 3 p
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    Far ultraviolet astronomy using the FAUST telescope (1981)
    In:  CASI
    Details
    Publication Date: 2006-06-04
    Description: The Far Ultraviolet Space Telescope (FAUST) a compact, wide field-of-view, far ultraviolet instrument designed for astronomical observations of extended and point sources is discussed. The design and application of the instrument are described. The prime objective is to observe faint astronomical sources with sensitivities higher than previously available. Scientific programs will include: (1) a search for ultraviolet stars which are predicted to exist at the stage of evolution prior to the final death of a star; (2) observations of galaxies and quasars; and (3) joint programs with other Spacelab 1 experiments. The secondary objective is to verify the suitability of the Spacelab as a platform for far ultraviolet astronomy: data will be provided on the ultraviolet background levels due to astronomical, terrestrial, and spacecraft generated sources; the levels of contaminants which affect ultraviolet instruments; and the capability of the Orbiter for stable pointing at celestial sources for useful periods of time.
    Keywords: ASTRONOMY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 3 p
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