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  • Drosophila melanogaster  (67)
  • 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics
  • 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
  • Geodesy
  • Modelling
  • Springer  (100)
  • 2005-2009  (23)
  • 1975-1979  (77)
  • 1950-1954
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  • 1
    Publication Date: 2021-06-21
    Description: Earthquake early warning systems (EEWS), based on real-time prediction of ground motion or structural response measures, may play a role in re- ducing vulnerability and/or exposure of buildings and lifelines. Indeed, seismologists have recently developed efficient methods for real-time es- timation of an event’s magnitude and location based on limited informa- tion of the P-waves. Therefore, when an event occurs, estimates of magni- tude and source-to-site distance are available, and the prediction of the structural demand at the site may be performed by Probabilistic Seismic Hazard Analysis (PSHA) and then by Probabilistic Seismic Demand Analysis (PSDA) depending upon EEWS measures. Such an approach contains a higher level of information with respect to traditional seismic risk analysis and may be used for real-time risk management. However, this kind of prediction is performed in very uncertain conditions which may affect the effectiveness of the system and therefore have to be taken into due account. In the present study the performance of the EWWS under development in the Campania region (southern Italy) is assessed by simu- lation. The earthquake localization is formulated in a Voronoi cells ap- proach, while a Bayesian method is used for magnitude estimation. Simu- lation has an empirical basis but requires no recorded signals. Our results, in terms of hazard analysis and false/missed alarm probabilities, lead us to conclude that the PSHA depending upon the EEWS significantly improves seismic risk prediction at the site and is close to what could be produced if magnitude and distance were deterministically known.
    Description: Published
    Description: 211-232
    Description: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Description: reserved
    Keywords: Earthquake Early ; Campania Region ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 2
    Publication Date: 2017-04-03
    Description: We compare the results obtained from the modelling of EDM, GPS, levelling and tilt data measured in the first part of the 19911993 eruption at Etna to the InSAR data acquired during the second part. The geodetic changes are very marked in the first half of the eruption and constrain a deflation source located at a few kilometers of depth ( 3 km b.s.l.), in agreement with other independent geophysical evidence. SAR data, available during the second part of the eruption, were analysed for different time intervals in the second part of the eruption. The interpretation of SAR interferograms reveals a large-scale but less marked deflation of the volcano that could be caused by a deeper source. This second source is in accord with a second deeper anomaly revealed by recent seismic investigations. The combination of geodetic data modelling and SAR images suggests a complex plumbing system composed at least of two possible storage regions located at different depths.
    Description: Published
    Description: 1345-1357
    Description: partially_open
    Keywords: Geodesy ; SAR Interferometry ; ground deformation ; Mt. Etna volcano ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.03. Geodesy::04.03.09. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
    Publication Date: 2017-04-04
    Description: Analysis of the historical records of Etnas eruptive activity for the past three centuries shows that, after the large 1669 eruption, a period of about 60 years of low-level activity followed. Starting from 1727, explosive activity (strombolian, lava fountaining and subplinian) at the summit crater increased exponentially to the present day. Since 1763, the frequency of flank eruptions also increased and this value remained high until 1960; afterward it further increased sharply. In fact, the number of summit and flank eruptions between 1961 and 2003 was four times greater than that of the pre-1960 period. This long-term trend of escalating activity rules out a pattern of cyclic behaviour of the volcano. We propose instead that the 16702003 period most likely characterises a single eruptive cycle which began after the large 1669 eruption and which is still continuing. On the basis of the eruptive style, two distinct types of flank eruptions are recognised: Class A and Class B. Class A eruptions are mostly effusive with associated weak strombolian activity; Class B eruptions are characterised by effusive activity accompanied by intense, long-lasting, strombolian and lava fountaining activity that produces copious tephra fallouts, as during the 2001 and 20022003 eruptions. Over the past three centuries, seven Class B eruptions have taken place with vents located mainly on the south-eastern flank, indicating that this sector of the volcano is a preferential zone for the intrusion of volatile-rich magma rising from the deeper region of the Etna plumbing system.
    Description: Published
    Description: 732-742
    Description: partially_open
    Keywords: Etna ; Historical record ; Summit activity ; Flank eruptions ; Eruptive behaviour ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
    Publication Date: 2017-04-04
    Description: The Monte Nuovo eruption is the most recent event that occurred at Phlegrean Fields (Italy) and lasted from 29 September to 6 October 1538. It was characterized by 2 days of quasi-sustained phreatomagmatic activity generating pumice-bearing pyroclastic density currents and forming a 130-m-high tuff cone (Lower Member deposits). The activity resumed after a pause of 2 days with two discrete Vulcanian explosions that emplaced radially distributed, scoria-bearing pyroclastic flows (Upper Member deposits). The juvenile products of Lower and Upper Members are, respectively, phenocryst-poor, light-coloured pumice and dark scoria fragments with K-phonolitic bulk compositions, identical in terms of both major and trace elements. Groundmass is formed by variable proportions of K-feldspar and glass, along with minor sodalite and Fe-Ti oxide present in the most crystallized samples. Investigations of groundmass compositions and textures were performed to assess the mechanisms of magma ascent, degassing and fragmentation along the conduit and implications for the eruptive dynamics. In pumice of the Lower Member groundmass crystal content increases from 13 to 28 vol% from the base to the top of the sequence. Products of the Upper Member consist of clasts with a groundmass crystal content between 30 and 40 vol% and of totally crystallized fragments. Crystal size distributions of groundmass feldspars shift from a single population at the base of the Lower Member to a double population in the remaining part of the sequence. The average size of both populations regularly increases from the Lower to the Upper Member. Crystal number density increases by two orders of magnitude from the Lower to the Upper Member, suggesting that nucleation dominated during the second phase of the eruption. The overall morphological, compositional and textural data suggest that the juvenile components of the Monte Nuovo eruption are likely to record variations of the magma properties within the conduit. The different textures of pumice clasts from the Lower Member possibly reflect horizontal gradients of the physical properties (P, T) of the ascending magma column, while scoriae from the second phase are thought to result from the disruption of a slowly rising plug crystallizing in response to degassing. In particular, crystal size distribution data point to syn-eruptive degassing-induced crystallization as responsible for the transition in eruptive style from the first to the second phase of the eruption. This mechanism not only has been proved to profoundly affect the dynamics of dome-forming calc-alkaline eruptions, but may also have a strong influence in driving the eruption dynamics of alkaline magmas of intermediate to evolved compositions.
    Description: Published
    Description: 601-621
    Description: reserved
    Keywords: Phlegrean Fields ; Vulcanian explosion ; Degassing ; Groundmass crystallization ; Eruption dynamics ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.02. Experimental volcanism ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 5
    Publication Date: 2017-04-04
    Description: For early-warning applications in particular, the reliability and efficiency of rapid scenario generation strongly depend on the availability of reliable strong ground-motion prediction tools. If shake maps are used to represent patterns of potential damage as a consequence of large earthquakes, attenuation relations are used as a tool for predicting peak ground-motion parameters and intensities. One of the limitations in the use of attenuation relations is that these have only rarely been retrieved from data collected in the same tectonic environment in which the prediction has to be performed. As a consequence, strong ground motion can result in underestimations or overestimations with respect to the recorded data. This also holds for Italy, and in particular for the Southern Apennines, due to limitations in the available databases, both in terms of distances and magnitude. Moreover, for “real-time” early-warning applications, it is important to have attenuation models for which the parameters can be easily upgraded when new data are collected, whether this has to be done during the earthquake rupture occurrence or in the post-event, when all the strong motion waveforms are available. Here we present a strong-motion attenuation relation for early-warning applications in the Campania region (Southern Apennines), Italy. The model has a classical analytical formulation, and its coefficients were retrieved from a synthetic strong-motion database created by using a stochastic approach. The input parameters for the simulation technique were obtained through the spectral analysis of waveforms of earthquakes recorded by the Istituto Nazionale di Geofisica e Vulcanologia (INGV) network for a magnitude range Md (1.5,5.0) in the last fifteen years, and they have been extrapolated to cover a larger range. To validate the inferred relation, comparisons with two existing attenuation relations are presented. The results show that the calibration of the attenuation parameters, i.e., geometric spreading, quality factor Q, static stress drop values along with their uncertainties, are the main concern.
    Description: Published
    Description: 133-152
    Description: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Description: reserved
    Keywords: A Strong Motion ; Earlywarning ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 6
    Publication Date: 2017-04-04
    Description: In the framework of an ongoing project financed by the Campania Region, a prototype system for seismic early and post-event warning is being developed and tested, based on a dense, wide dynamic seismic network (ISNet) and under installation in the Apennine belt region. This paper reports the characteristics of the seismic network, focussing on the required technological innovation of the different seismic network components (data-logger, sensors and data communication). To ensure a highly dynamic recording range, each station is equipped with two types of sensors: a strong-motion accelerometer and a velocimeter. Data acquisition at the seismic stations is performed using Osiris-6 model data-loggers made by Agecodagis. Each station is supplied with two (120 W) solar panels and two 130 Ah gel cell batteries, ensuring 72-h autonomy for the seismic and radio communication equipment. The site is also equipped with a GSM/GPRS programmable control/alarm system connected to several environmental sensors (door forcing, solar panel controller, battery, fire, etc) and through which the site status is known in real time. The data are stored locally on the hard-disk and, at the same time, continuously transmitted by the SeedLink protocol to local acquisition/analysis nodes (Local Control Center) via Wireless LAN bridge. At each LCC site runs a linux Earthworm system which stores and manages the acquired data stream. The real-time analysis system will perform event detection and localization based on triggers coming from data-loggers and parametric information coming from the other LCCs. Once an event is detected, the system will performs automatic magnitude and focal mechanism estimations. In the immediate post-event period, the RISSC performs shaking map calculations using parameters from the LCCs and/or data from the event database. The recorded earthquake data are stored into an event database, to be available for distribution and visualization for further off-line analyses. The seismic network will be completed in two stages: • Deployment of 30 seismic stations along the southern Apennine chain (to date almost completed) • Setting up a carrier-class radio communication system for fast and reliable data transmission, and installation of 10 additional seismic stations.
    Description: Published
    Description: 325 - 341
    Description: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Description: reserved
    Keywords: Monitoring Infrastructure ; Early-warning Applications ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 7
    Publication Date: 2017-04-04
    Description: Ground deformation occurring on the southern flank of Mt Etna volcano during the JulyAugust 2001 eruption was monitored by GPS measurements along an EW profile crossing the fissure system. This profile was measured eight times during the eruption, using the 'stop and go' semi-kinematic technique. Horizontal and vertical displacements between GPS surveys are reported for each station. The most significant event is a deformation episode occurring during the first week of the eruption, between 2527 July. Displacements were measured on benchmarks close to the eruptive fissure and the tensile 1989 fracture. Data inversions for measured displacements were performed using the Okada model. The model shows the narrowing of the 2001 dyke accompanied by a dextral dislocation along an east-dipping fault, parallel to the 1989 fracture.
    Description: Published
    Description: 336-341
    Description: partially_open
    Keywords: GPS ; Ground deformation ; Modelling ; Volcano monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.03. Geodesy::04.03.09. Instruments and techniques ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 8
    Publication Date: 2017-04-04
    Description: The 200203 Mt Etna flank eruption began on 26 October 2002 and finished on 28 January 2003, after three months of continuous explosive activity and discontinuous lava flow output. The eruption involved the opening of eruptive fissures on the NE and S flanks of the volcano, with lava flow output and fire fountaining until 5 November. After this date, the eruption continued exclusively on the S flank, with continuous explosive activity and lava flows active between 13 November and 28 January 2003. Multi-disciplinary data collected during the eruption (petrology, analyses of ash components, gas geochemistry, field surveys, thermal mapping and structural surveys) allowed us to analyse the dynamics of the eruption. The eruption was triggered either by (i) accumulation and eventual ascent of magma from depth or (ii) depressurisation of the edifice due to spreading of the eastern flank of the volcano. The extraordinary explosivity makes the 200203 eruption a unique event in the last 300 years, comparable only with La Montagnola 1763 and the 2001 Lower Vents eruptions. A notable feature of the eruption was also the simultaneous effusion of lavas with different composition and emplacement features. Magma erupted from the NE fissure represented the partially degassed magma fraction normally residing within the central conduits and the shallow plumbing system. The magma that erupted from the S fissure was the relatively undegassed, volatile-rich, buoyant fraction which drained the deep feeding system, bypassing the central conduits. This is typical of most Etnean eccentric eruptions. We believe that there is a high probability that Mount Etna has entered a new eruptive phase, with magma being supplied to a deep reservoir independent from the central conduit, that could periodically produce sufficient overpressure to propagate a dyke to the surface and generate further flank eruptions.
    Description: Published
    Description: 314-330
    Description: partially_open
    Keywords: Multi-disciplinary study ; Mount Etna ; 2002–03 eruption ; Eccentric eruptions ; Flank activity ; Etna feeding system ; Volcanic processes ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 9
    Publication Date: 2017-04-04
    Description: It has been argued that the dominant period T_p derived from the initial seconds of a seismogram, hence only depending on the initial phases of earthquake rupture, seems to scale with the final size of the earthquake. We provide a physical interpretation for the observed scaling and explain how the final earthquake size could be controlled by the initial phase of rupture.
    Description: Published
    Description: 9-19
    Description: 3.1. Fisica dei terremoti
    Description: reserved
    Keywords: early warning ; fracture energy ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 10
    Publication Date: 2017-04-04
    Description: Mount Etna is an open conduit volcano, characterised by persistent activity, consisting of degassing and explosive phenomena at summit craters, frequent flank eruptions, and more rarely, eccentric eruptions. All eruption typologies can give rise to lava flows, which represent the greatest hazard by the volcano to the inhabited areas. Historical documents and scientific papers related to the 20th century effusive activity have been examined in detail, and volcanological parameters have been compiled in a database. The cumulative curve of emitted lava volume highlights the presence of two main eruptive periods: (a) the 1900–1971 interval, characterised by a moderate slope of the curve, amounting to 436 · 106 m3 of lava with average effusion rate of 0.2 m3/s and (b) the 1971–1999 period, in which a significant increase in eruption frequency is associated with a large issued lava volume (767 · 106 m3) and a higher effusion rate (0.8 m3/s). The collected data have been plotted to highlight different eruptive behaviour as a function of eruptive periods and summit vs. flank eruptions. The latter have been further subdivided into two categories: eruptions characterised by high effusion rates and short duration, and eruptions dominated by low effusion rate, long duration and larger volume of erupted lava. Circular zones around the summit area have been drawn for summit eruptions based on the maximum lava flow length; flank eruptions have been considered by taking into account the eruptive fracture elevation and combining them with lava flow lengths of 4 and 6 km. This work highlights that the greatest lava flow hazard at Etna is on the south and east sectors of the volcano. This should be properly considered in future land-use planning by local authorities.
    Description: Published
    Description: 407–443
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Mt. Etna ; effusive activity ; database ; lava flow length ; eruptive fractures ; vent elevation ; hazard zonation ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 11
    Publication Date: 2017-04-04
    Description: Flank instability and collapse are observed at many volcanoes. Among these, Mt. Etna is characterized by the spreading of its eastern and southern flanks. The eastern spreading area is bordered to the north by the EW-trending Pernicana Fault System (PFS). During the 20022003 Etna eruption, ground fracturing along the PFS migrated eastward from the NE Rift, to as far as the 18 km distant coastline. The deformation consisted of dextral en-echelon segments, with sinistral and normal kinematics. Both of these components of displacement were one order of magnitude larger (~1 m) in the western, previously known, portion of the PFS with respect to the newly surveyed (~9 km long) eastern section (~0.1 m). This eastern section is located along a pre-existing, but previously unknown, fault, where displaced man-made structures give overall slip rates (11.9 cm/year), only slightly lower than those calculated for the western portion (1.42.3 cm/year). After an initial rapid motion during the first days of the 20022003 eruption, movement of the western portion of the PFS decreased dramatically, while parts of the eastern portion continued to move. These data suggest a model of spreading of the eastern flank of Etna along the PFS, characterized by eruptions along the NE Rift, instantaneous, short-lived, meter-scale displacements along the western PFS and more long-lived centimeter-scale displacements along the eastern PFS. The surface deformation then migrated southwards, reactivating, one after the other, the NNWSSE-trending Timpe and Trecastagni faults, with displacements of ~0.1 and ~0.04 m, respectively. These structures, along with the PFS, mark the boundaries of two adjacent blocks, moving at different times and rates. The new extent of the PFS and previous activity over its full length indicate that the sliding eastern flank extends well below the Ionian Sea. The clustering of seismic activity above 4 km b.s.l. during the eruption suggests a deep décollement for the moving mass. The collected data thus suggests a significant movement (volume 〉1,100 km3) of the eastern flank of Etna, both on-shore and off-shore.
    Description: Published
    Description: 417-430
    Description: partially_open
    Keywords: Volcano spreading ; Fracturing ; Mt. Etna ; Pernicana Fault System ; NE Rift ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
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  • 12
    Publication Date: 2017-04-04
    Description: We have characterized pumice products belonging to the climactic phase of the 800-year-b.p. Quilotoa eruption. Bulk rock compositions, petrography, mineral, and glass chemistry and textural investigations were performed on the three end-member pumice types, namely white, gray, and mingled pumices. All the investigated pumice clasts are dacites characterized by the same bulk rock composition and mineralogical assemblage, but glass compositions and bulk textures change according to different pumice types. White pumice has higher crystallinity (~48 wt%), abundant euhedral pheno/microphenocrysts, no groundmass microlites, the most evolved glass compositions (7478 wt% SiO2), and heterogeneous vesicle populations marked by deformed and highly coalesced vesicles with thin walls. Gray pumice exhibits lower crystallinity (2936 wt%), abundant broken and/or resorbed crystals, ubiquitous groundmass phenocryst fragments and microlites, the widest range of glass compositions (6978 wt% SiO2), and quite homogeneous poorly deformed and coalesced vesicles with thicker walls. Mingled pumices are characterized by the alternation of bands or patches with white and gray pumice compositional and textural characteristics. We attribute heterogeneities in glass compositions and crystal and vesicle textures to processes occurring within volcanic conduits as magma is ascending to the surface. In particular, the above observations and results are consistent with an origin of a gray magma by heating of the original white magma in a strongly sheared region of the conduit because of a mechanism of viscous dissipation and crystal grinding and resorption at the conduit walls. The less viscous gray magma, therefore, would enable the onset and preservation of a high mass flux of the eruption otherwise difficult to explain for highly viscous crystal-rich dacitic magmas.
    Description: Published
    Description: 307-321
    Description: partially_open
    Keywords: Plinian eruption ; Crystal-rich magma ; Crystal grinding ; Pumice types ; Viscous dissipation ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 13
    Publication Date: 2017-04-04
    Description: A prototype system for earthquake early warning and rapid shake map evaluation is being developed and tested in southern Italy based on a dense, dynamic seismic network (accelerometers + seismometers) under installation in the Apenninic belt region (Irpinia Seismic Network). It can be classified as a regional Earthquake Early Warning System consisting of a broad-based seismic sensor network covering a portion or the entire area which is threatened by the quake's strike. The real time magnitude estimate will take advantage from the high spatial density of the network in the source region and the broad dynamic range of installed instruments. Based on the offline analysis of high quality strong-motion data bases recorded in Italy, several methods are envisaged, using different observed quantities (peak amplitude, dominant frequency, square velocity integral, …) to be measured on seismograms, as a function of time, both on P and early-S wave signals. Results from the analysis of the Italian strong motion database point out the possibility of using low-pass filtered displacement and velocity peak amplitudes measured in time windows lasting less than 3-4 sec after the first P- or S-wave arrivals. These parameters show they are robustly correlated with moment magnitude. The correlation found of 3Hz low-pass filtered PGV and PGD with magnitude is discussed and interpreted in terms of plausible dynamic models of the earthquake rupture process during its initial stage.
    Description: Published
    Description: 45-63
    Description: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Description: reserved
    Keywords: Real-time Estimation ; Magnitude ; Seismic Early Warning ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 14
    Publication Date: 2017-04-04
    Description: The southernmost sector of the Italian peninsula is crossed by an almost continuous seismogenic belt capable of producing M ~ 7 earthquakes and extending from the Calabrian Arc, through the Messina Straits, as far as Southeastern Sicily. Though large earthquakes occurring in this region during the last Millennium are fairly well known from the historical point of view and seismic catalogues may be considered complete for destructive and badly damaging events (IX £ Io £ XI MCS), the knowledge and seismic completeness of moderate earthquakes can be improved by investigating other kinds of documentary sources not explored by the classical seismological tradition. In this paper, we present a case study explanatory of the problem, regarding the Ionian coast between the Messina Straits and Mount Etna volcano, an area of North-eastern Sicily lacking evidence of relevant seismic activity in historical times. Now, after a systematic analysis of the 18th century journalistic sources (gazettes), this gap can be partly filled by the rediscovery of a seismic sequence that took place in 1780. According to the available catalogues, the only event on record for this year is a minor shock (Io = VI MCS, Mw = 4.8) recorded in Messina on March 28, 1780. The newly discovered data allow to reinstate it as the mainshock (Io = VII–VIII MCS, Mw = 5.6) of a significant seismic period, which went on from March to June 1780, causing severe damage along the Ionian coast of North-eastern Sicily. The source responsible for this event appears located offshore, 40-km south of the previous determination, and is consistent with the Taormina Fault suggested by the geological literature, developing in the low seismic rate zone at the southernmost termination of the 1908 Messina earthquake fault.
    Description: Published
    Description: reserved
    Keywords: Historical seismology ; Macroseismic data ; MCS-EMS intensity scales ; 1780 Seismic sequence ; Seismotectonics ; NE Sicily ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
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  • 15
    Publication Date: 2022-05-30
    Description: Scientific investigations in Antarctica are, for many different reasons, a challenging and fascinating task. Measurements, observations and field operations must be carefully planned well in advance and the capacity of successfully meeting the goals of a scientific project is often related to the capacity of forecasting and anticipating the many different potential mishaps. In order to do that, experience and logistic support are crucial. On the scientific side, the team must be aware of its tasks and be prepared to carry out observations in a hostile environment: both technology and human resources have to be suitably selected, prepared, tested and trained. On the logistic side, nations, institutions and any other organisation involved in the expeditions must ensure the proper amount of competence and practical support. The history of modern Italian Antarctic expeditions dates back to the middle 80’s when the first infrastructures of “Mario Zucchelli Station”, formerly Terra Nova Bay Station, were settled at Terra Nova Bay, Northern Victoria Land. Only a few years later, the first geodetic infrastructures were planned and built. Italian geodetic facilities and activities were, ever since, being constantly maintained and developed. Nowadays, the most remarkable geodetic infrastructures are the permanent Global Positioning System (GPS) station (TNB1) installed at Mario Zucchelli and the GPS geodetic network Victoria Land Network for DEFormation control (VLNDEF) entirely deployed on an area extending between 71° S and 76° S and 160° E and 170° E. These facilities do not only allow carrying out utmost geodetic investigations but also posses interesting capacities on the international multidisciplinary scientific scenario. In order to fully exploit their potentiality, management and maintenance of the infrastructure are crucial; nevertheless, in order to perform high quality scientific research, these abilities must be coupled with the knowledge concerning a proper use and a correct processing of the information that these infrastructures can provide. This work focuses on the different methods that can be applied to process the observations that are performed with GPS technique in Northern Victoria Land, aiming at reaching the highest accuracy of results and assuring the larger significance and versatility of the processing outcomes. Three software were used for the analysis, namely: Bernese v.5.0, Gipsy/Oasis II and Gamit/Globk. The working data sets are (i) the permanent GPS station TNB1 observations continuously performed since 1998 and (ii) the five episodic campaigns performed on the sites of VLNDEF. The two infrastructures can be regarded as neat examples of standard geodetic installation in Antarctica. Therefore, the technological solutions that were adopted and applied for establishing the GPS permanent station and the VLNDEF geodetic network as well as the data processing strategies and the data analysis procedures that were tested on their observation will be illustrated in detail. The results will be presented, compared and discussed. Furthermore, their potentials and role in geodetic research will be carefully described; their versatility will also be highlighted in the foreground of a multidisciplinary Antarctic international scientific activity.
    Description: Published
    Description: 37-72
    Description: 1.8. Osservazioni di geofisica ambientale
    Description: reserved
    Keywords: Antarctica ; Geodesy ; Geodetic Infrastructures ; GPS ; 01. Atmosphere::01.01. Atmosphere::01.01.08. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 16
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    Development genes and evolution 182 (1977), S. 69-74 
    ISSN: 1432-041X
    Keywords: Drosophila melanogaster ; Male foreleg disk ; Capacity of transdetermination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In the male foreleg disk ofDrosophila melanogaster the cells capable of transdetermination are clustered in a specific region within the upper half of the disk. Cells outside this region cannot transdetermine under any of the experimental conditions thus far applied. Transdetermination occurs when cells capable of transdetermination are stimulated to a certain extent of additional proliferation. This can be achieved either by exposing these cells at a wound surface of an intact fragment, or by dissociation.
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  • 17
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    Development genes and evolution 187 (1979), S. 151-165 
    ISSN: 1432-041X
    Keywords: Oogenesis ; Embryogenesis ; Two-dimensional gels ; Protein synthesis ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Protein synthesis in egg follicles and blastoderm embryos ofDrosophila melanogaster has been studied by means of two-dimensional gel electrophoresis. Up to 400 polypeptide spots have been resolved on autoradiographs. Stage 10 follicles (for stages see King, 1970) were labelled in vitro for 10 to 60 min with35S-methionine and cut with tungsten needles into an anterior fragment containing the nurse cells and a posterior fragment containing the oocyte and follicle cells. The nurse cells were found to synthesize a complex pattern of proteins. At least two proteins were detected only in nurse cells but not in the oocyte even after a one hour labelling period. Nurse cells isolated from stages 9, 10 and 12 follicles were shown to synthesize stage specific patterns of proteins. Several proteins are synthesized in posterior fragments of stage 10 follicles but not in anterior fragments. These proteins are only found in follicle cells. No oocyte specific proteins have been detected. Striking differences between the protein patterns of anterior and posterior fragments persist until the nurse cells degenerate. In mature stage 14 follicles, labelled in vivo, no significant differences in the protein patterns of isolated anterior and posterior fragments could be detected; this may be due to technical limitations. At the blastoderm stage localized synthesis of specific proteins becomes detectable again. When blastoderm embryos, labelled in vivo, are cut with tungsten needles and the cells are isolated from anterior and posterior halves, differences become apparent. The pole cells located at the posterior pole are highly active in protein synthesis and contribute several specific proteins which are found exclusively in the posterior region of the embryo. In this study synthesis of specific proteins could only be demonstrated at those developmental stages which are characterized by the presence of different cell types within the egg chamber, while no differences were detected when stage 14 follicles were cut and anterior and posterior fragments analyzed separately. The differences in the pattern of protein synthesis by pole cells and blastoderm cells indicate that even the earliest stages of determination are reflected by marked changes at the biochemical level.
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  • 18
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    Development genes and evolution 183 (1977), S. 249-268 
    ISSN: 1432-041X
    Keywords: Pattern-formation ; Embryogenesis ; Maternal-effect mutants ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mutationbicaudal (Bull, 1966) causes embryos to develop a longitudinal mirror image duplication of the posteriormost abdominal segments, while head and thorax are missing. These embryos occur with varying frequencies among eggs laid by mutant females, irrespective of the paternal genotype. Recombination and deletion mapping indicate thatbicaudal (bic) is a recessive, hypomorphic, maternal-effect mutation mapping at a single locus on the second chromosome ofDrosophila melanogaster close tovg (67.0±0.1). The frequency of bicaudal embryos depends on the age of the mother, her genetic constitution and the temperature at which she is raised. Best producers are very young females hemizygous forbic (bic/Df(2)vg B ) at 28° C. Under these conditions 80% to 90% of the eggs which differentiate can show the bicaudal embryo phenotype. Upon ageing of the mother the frequency of bicaudal embryos declines rapidly, and most of the eggs develop the normal body pattern. Temperature shift experiments suggest a temperature-sensitive period at the onset of vitellogenesis. The mutation causes several types of abnormalities in the segment pattern of theDrosophila embryo, which are interpreted as various degrees of expression of the mutant character. The most frequent abnormal phenotype is the symmetrical bicaudal embryo with one to five abdominal segments duplicated. Less frequent are asymmetrical types, in which the smaller number of segments is always in the anterior reversed part. Other phenotypes are embryos with missing or rudimentary heads, and embryos with irregular gaps in the segment pattern. In bicaudal embryos, the pole cells, formed at the posterior pole of the egg prior to blastoderm formation, are not duplicated at the anterior. The significance of thebicaudal phenotypes for embryonic pattern-formation inDrosophila is discussed.
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  • 19
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    Development genes and evolution 183 (1977), S. 165-169 
    ISSN: 1432-041X
    Keywords: Clones ; Nervous system ; Shibire ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mitotic recombination was induced, by X-irradiation at the blastoderm stage, in flies heterozygous for one of the temperature-sensitive paralytic mutationsshibire andtp-2. The results show that these mutations can be used to detect the presence of clones in the central nervous system through the temperature-sensitive paralysis of individual legs. Mitotic recombination can also be used to examine the effects of these mutations in the peripheral nervous system; shibire is thus shown to affect the function of sensory neurons.
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  • 20
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    Development genes and evolution 180 (1976), S. 107-119 
    ISSN: 1432-041X
    Keywords: Drosophila melanogaster ; Cell lines ; Isoenzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Our previous isoenzyme investigation ofDrosophila melanogaster cell lines in vitro has been completed with twelve further enzyme systems. The “enzyme profiles” seem to be in good agreement with a previous hypothesis concerning the precise origin of these cell lines (probably from imaginal discs or nervous tissues). Our results have been summarized with reference to the biochemical genetic map ofDrosophila melanogaster in order to consider a possible functional organization of the genome.
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  • 21
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    Development genes and evolution 184 (1978), S. 41-56 
    ISSN: 1432-041X
    Keywords: Drosophila melanogaster ; Female germ line ; Mosaics ; Stem cell divisions ; Metafemale ; Sterility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Our report presents an analysis of the development and dynamics of the female germ line inDrosophila. Females were produced that were mosaic either for attached-X chromosomes $$(\widehat{XX})$$ and a ring-X (triplo-X-diplo-X), or for $$\widehat{XX}$$ and a marked Y-chromosome $$(\widehat{XX}/Y - \widehat{XX}/O)$$ . The germ-line and genitalia of these females were analysed by direct microscopic observation or by examination of the progeny. Eggs derived from triplo-X germ cells were hardly capable of supporting development, with most of the zygotes dying during embryonic development. The analysis of the germ line was therefore carried out mainly by direct observation of histochemically stained developing oocytes in the ovaries of mosaic females. The total germ cell population of both ovaries of a female was mosaic in 22–29% of the tested animals. From this frequency of mosaicism we estimated the number of functional primordial germ cells to be betwen 3 and 6 cells at the blastoderm stage. At this stage the cell lineages for the left and right ovary are not yet separated. The germ cell population of individual ovarioles was frequently mosaic which shows that the few stem cells in an ovariole are recruited as a group and are not clonal descendants of a single ancestor cell per ovariole. An analysis of the sequential pattern of oocyte-nurse cell cysts in mosaic ovarioles revealed that neighbouring cysts tend to be of the same genotype. This suggests that the stem cells of the adult ovaries preferentially divide in bursts, one of them giving rise to two, three and sometimes even more cystocytes in a row. In addition, the foci for lethality and sterility of the triplo-X condition were determined. Non-mosaic triplo-X females (metafemales) are hardly viable and invariably sterile. Using our mosaics, the focus forlethality could be mapped to a region very near the ventral prothoracic discs. The focus forsterility resides in the genitalia, since flies with triplo-X genitalia never laid any eggs, regardless of the genotype of their ovaries.
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  • 22
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    Development genes and evolution 187 (1979), S. 167-177 
    ISSN: 1432-041X
    Keywords: Pyrimidine biosynthesis ; rudimentary mutants ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The X-linkedrudimentary (r) mutants ofDrosophila melanogaster are pyrimidine auxotrophs and require exogenous pyrimidines (Nørby, 1970; Falk, 1976). We have established a set ofrudimentary cell lines that are derived from embryos, homozygous for eitherr 1 orr 36. The enzymatic activities of the pyrimidine synthesizing enzymes were measured in the mutant lines. We have further investigated the nutritional requirements of the mutant cells in vitro by using a pyrimidine free culture medium. Ther 1 cell lines were found to express 3–7%dihydroorotase (DHOase) activity as compared to a wildtype cell line. Reducedaspartate transcarbamylase (ATCase) activity was measured in somer 1 cell lines whereas wildtypecarbamylphosphate synthetase (CPSase) activity is expressed in allr 1 cell lines. Ther 36 cell line expresses wildtype activity ofDHOase andCPSase. ATCase activity was found to be reduced to 10% of the wildtype activity. The mutant cell lines do not proliferate in pyrimidine free minimal medium and cell proliferation is obtained by the addition of crude RNA. Proliferation of ther 1 cells is restored by the supplementation of the minimal medium withdihydroorotate whereas proliferation of ther 36 cells is restored by supplementation with eitherdihydroorotate orcarbamylaspartate. The results demonstrate that therudimentary phenotypesr 1 andr 36 are expressed at the cellular level and that the two mutant cell types behave as cellular pyrimidine auxotrophs in vitro.
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  • 23
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    Development genes and evolution 180 (1976), S. 73-77 
    ISSN: 1432-041X
    Keywords: Ecdysones ; Imaginal discs ; Fat body ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effect of suboptimal levels of α-ecdysone on the differentiation in vitro ofDrosophila melanogaster wing discs was enhanced by the addition of larval fat body to the cultures. However, similar experiments with β-ecdysome showed no enhancement. It is suggested that a partial conversion of α-ecdysone to β-ecdysone by the fat body may well account for these results.
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  • 24
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    Development genes and evolution 181 (1977), S. 309-320 
    ISSN: 1432-041X
    Keywords: Drosophila melanogaster ; Male foreleg disc ; Pattern regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The developmental potentials of the four quadrants of the male foreleg disc ofDrosophila melanogaster were analysed by culturing excised quadrants for 3 days and 10 days in adult hosts prior to metamorphosis. 2. The cultured pieces underwent different types of pattern regulation in a circular direction. The upper medial piece was able to regenerate the missing structures of the disc, thus confirming the findings of earlier reports. The three remaining pieces could undergo pattern duplication in mirror-image symmetry. The lower medial piece revealed in addition a slight capacity for regeneration from the vertical cut surface. 3. The duplicating pieces differed markedly in their frequencies of pattern duplication: duplications occurred with very high frequencies in lower medial pieces, with intermediate frequencies in upper lateral pieces, and with very low frequencies in lower lateral pieces. 4. Both lower lateral and upper lateral pieces underwent a progressive loss of most markers with increasing culture time. 5. Claws were regenerated solely by upper medial pieces. 6. Transdetermined structures, too, were encountered only in upper medial pieces. 7. The results are discussed with respect to the two major current models of pattern regulation in imaginal discs, the “gradient model” and the “clock model”. 8. It is suggested that the differences in the frequencies of pattern duplication reflect the unequal spacing of circular positional values within the three duplicating quadrants. Under this assumption the data indicate a progressive decrease in the density of circular positional values with increasing distance from the upper medial quadrant of the disc.
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  • 25
    ISSN: 1573-4927
    Keywords: aldehyde oxidase ; xanthine dehydrogenase ; Drosophila melanogaster ; molybdenum
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two new mutants, deficient in aldehyde oxidase and xanthine dehydrogenase, have been isolated from a wild-type stock of Drosophila melanogaster and have been provisionally termed lxd c and lxd d, respectively, as both mutants appear to be allelic with lxd (low xanthine dehydrogenase). An analysis has been made of the effects of dietary molybdenum on lxd, lxd c, lxdd, lao (low aldehyde oxidase), mal (maroon-like eye color), and pac (Pacific) wild-type flies. On the lower dietary levels of 10 −3 M and 10 −2 M molybdenum, increases in specific activity of both enzymes were observed only in lxd. Furthermore, two- to three-fold increases in specific activity of both enzymes occurred in all strains, except mal, when cultured on 5×10 −2 M molybdenum. The lxd and lxd c strains failed to survive on this high concentration of the ion. Similar concentrations of molybdenum had no effect in vitro. An extra electrophoretic band of xanthine dehydrogenase was observed on polyacrylamide gel from extracts of wild-type flies cultured on certain levels of molybdenum, but its appearance was not always correlated with the increases in specific activity.
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  • 26
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    Biochemical genetics 14 (1976), S. 357-371 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; poly(A)-containing RNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The size range of poly(A)-containing RNA from Drosophila melanogaster embryos has been estimated by hybridization with 3H-labeled poly(U) and subsequent fractionation on sucrose gradients. The median size of nuclear poly(A)-containing RNA is about 30 S (6000 nucleotides), and the median size of cytoplasmic poly(A)-containing RNA is about 17 S (1800 nucleotides). The relationship of these sizes to messenger RNA needed to code for protein and to the length of DNA contained in a chromomere is discussed.
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  • 27
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    Biochemical genetics 14 (1976), S. 259-270 
    ISSN: 1573-4927
    Keywords: GTP cyclohydrolase ; Drosophila melanogaster ; pteridines ; dihydroneopterin triphosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The first enzyme (named GTP cyclohydrolase) in the pathway for the biosynthesis of pteridines has been partially purified from extracts of late pupae and young adults of Drosophila melanogaster. This enzyme catalyzes the hydrolytic removal from GTP of carbon 8 as formate and the synthesis of 2-amino-4-hydroxy-6-(d-erythro-1′,2′,3′-trihydroxypropyl)-7,8-dihydropteridine triphosphate (dihydroneopterin triphosphate). Some of the properties of the enzyme are as follows: it functions optimally at pH 7.8 and at 42 C; activity is unaffected by KCl and NaCl, but divalent cations (Mg2+, Mn2+, Zn2+, and Ca2+) are inhibitory; the K m for GTP is 22 μm; and the molecular weight is estimated at 345,000 from gel filtration experiments. Of a number of nucleotides tested, only GDP and dGTP were used to any extent as substrate in place of GTP, and these respective compounds were used only 1.8% and 1.5% as well as GTP.
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  • 28
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    Biochemical genetics 14 (1976), S. 611-617 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; phenol oxidases ; spectrophotometry ; electrophoresis ; suppression ; ribosomal proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An interaction between the lozenge gene and the suppressor of forked gene of Drosophila melanogaster has been investigated both spectrophotometrically and electrophoretically. The nature of this interaction is such that certain lozenge alleles appear to be phenotypically suppressed while others are enhanced or unaffected, and the results reported demonstrate that the effect can clearly be observed at the biochemical level. Earlier observations have suggested that the suppressor of forked gene codes for a ribosomal protein, and this hypothesis is discussed.
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  • 29
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    Biochemical genetics 15 (1977), S. 93-100 
    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase (ADH) ; genetic polymorphism ; selection ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In the natural populations +Tüb, +Prov, and +Rov, similar Adh F allele frequencies occur (q F=0.11, 0.18, and 0.08, respectively). However, there is a discrepancy in that the Adh F allele in +Tüb is closely linked to the lethal factor 1(2)Stm, which reduces relative fitness of the F phenotype to zero. In spite of this, polymorphism is maintained also in +Tüb, because the heterozygotes are superior to the homozygous S type (relative fitness=0.88). Under laboratory culture conditions, in +Tüb the relative fitness of the S genotype further decreases to 0.6. After outcrossing the lethal factor, relative fitnesses for S, FS, and F become 0.6, 1, and 0.48, respectively, implying that fitness for S remains the same. Relative values for S, FS, and F in +Prov, not affected by the lethal factor, are calculated by the maximum average fitness method to be 1, 1.2, and 0.2 under the assumption that heterozygous FS are similarly superior to S as in the natural +Tüb population and all allele frequencies found are stable equilibrium values.
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  • 30
    ISSN: 1573-4927
    Keywords: l-glycerol-3-phosphate dehydrogenase (α-GPDH) ; isozymes ; development ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The basis for the differentiation of l-glycerol-3-phosphate dehydrogenase (α-GPDH) into larval and adult isozymes in Drosophila melanogaster was investigated by the correlation of a lack of appearance of each isozyme during development within Drosophila bearing α-GPDH “null” alleles and by the study of a putative conversion factor. Conversion studies indicate the presence of a heat-labile RNase-resistant conversion factor present in crude larval extracts with the ability to convert GPDH-1 to GPDH-2 and GPDH-3 but not vice versa. In addition, “null” mutations at the Gpdh locus obliterate all isozymatic species of α-GPDH in all developmental stages. These observations suggest that all α-GPDH isozymes are the product of a single structural gene and that the multiple forms of this enzyme arise during successive developmental stages through an epigenetic modification of the primary Gpdh + polypeptide. Finally, observations are reported which bear on the functional divergence of the α-glycerophosphate cycle in the adult and larval stage of development.
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  • 31
    ISSN: 1573-4927
    Keywords: allozymes ; thermostability ; alcohol dehydrogenase ; Drosophila melanogaster ; natural populations
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Drosophila melanogaster collected from natural populations were examined fo thermostability variants within electrophoretic mobility classes of two enzymes. In alcohol dehydrogenase, two discrete forms of the “slow” allozyme and three discrete forms of the “fast” allozyme were revealed by postelectrophoretic treatments ranging from 15 sec at 40 C to 40 sec at 43 C. All variants have been mapped to within 0.7 unit of the Adh locus. Results of a geographic survey indicate that two alleles giving rise to fast-moderate and slow-moderate allozymes are common everywhere; other variants have a collective frequency ranging from 0% to 7%. In a test of the possibility that the rare Adh alleles could be generated by intragenic recombination between the two common alleles, electrophoresis and heat treatment of progeny recombinant for flanking markers of Adh revealed no new allozymes. Among 27 stocks containing slow α-glycerophosphate dehydrogenase allozymes and 109 fast stocks, heat treatments revealed no additional variation.
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  • 32
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; GTP cyclohydrolase ; development ; pteridine biosynthesis ; mutants
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The reaction catalyzed by GTP cyclohydrolase is the first unique step of pteridine biosynthesis in Drosophila melanogaster and is therefore likely to be an important control point. GTP cyclohydrolase activity varies during development, showing two distinct peaks of activity—one at pupariation and a much larger peak at emergence. Most of the early pupal enzyme is located in the body region, whereas in late pupal and early adult life most of the activity is found in the head. Mixing experiments indicate that developmental changes in activity are not due to changes in the level of a direct effector of GTP cyclohydrolase. The mutants raspberry and prune show an increased GTP cyclohydrolase activity at pupariation relative to wild type, but a decreased enzyme activity at emergence. The changes in GTP cyclohydrolase activity are reflected in changes in pteridine levels in these mutants. Several lines of evidence suggest that neither locus is the structural gene for GTP cyclohydrolase. The raspberry and prune gene products may play a specific role in regulating GTP cyclohydrolase activity during development.
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  • 33
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    Biochemical genetics 16 (1978), S. 1113-1134 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; isozymes ; position effect ; segmental aneuploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A deoxyribonuclease, called DNase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the enzyme maps genetically to 61.8 on the right arm of the third chromosome. Cytogenetically, DNase-1 has been localized to within five to ten bands between 90C-2 and 90E. This analysis utilizes both electrophoretic variants and the Y-autosome translocations of Lindsley et al. (1972). DNase-1 is present in all stages of the life cycle, and the paternal genome actively contributes DNase-1 to the embryo between 0 and 1 hr after fertilization.
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  • 34
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    Biochemical genetics 16 (1978), S. 159-170 
    ISSN: 1573-4927
    Keywords: alcohol dehydrogenase ; allozyme properties and amounts ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Among strains of Drosophila melanogaster each derived from a single fertilized female taken from natural populations, there is variation in both alcohol dehydrogenase (ADH) activity and the amount of ADH protein. The correlation between ADH activity and number of molecules over all strains examined is 0.87 or 0.96 in late third instar larvae depending on whether the substrate is 2-propanol or ethanol. With respect to the two common electrophoretic allozymic forms, F and S, segregating in these populations, the FF strains on the whole have higher ADH activities and numbers of ADH molecules than the SS strains. Over all strains examined, enzyme extracts from FF strains have a mean catalytic efficiency per enzyme molecule higher than that of enzyme extracts from SS strains when ethanol is the substrate, and much higher when 2-propanol is the substrate. One FF strain had an ADH activity/ADH protein ratio characteristic of SS strains.
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  • 35
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; alcohol tolerance ; alcohol utilization ; alcohol dehydrogenase ; aldehyde oxidase ; allozymes
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Alcohol dehydrogenase is necessary for ethanol detoxification and metabolic utilization. It has been generally assumed that aldehyde oxidase (AO) produced by the Aldox locus (3–56.7) is necessary for a further transformation of acetaldehyde into acetate. We find that various mutant strains (ma-l or Aldox n) which do not produce an active enzyme show about the same tolerance to alcohol as do wild strains. This physiological paradox is probably to be explained by the discovery of another locus (not localized) which produced a small amount of AO in all tested strains. The adaptive significance of the genetically polymorphic Aldox locus is probably to be looked for in physiological pathways other than ethanol metabolism.
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  • 36
    ISSN: 1573-4927
    Keywords: nonelectrophoretic structural variability ; Drosophila melanogaster ; phosphoglucomutase ; genetic polymorphism ; heat denaturation study
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    Notes: Abstract A simple procedure is described to detect genetic heterogeneity within electrophoretic classes at a locus in Drosophila, based on electrophoresis and heat denaturation studies. Temperature-resistant (tr) and temperature-sensitive (ts) isoelectrophoretic alleles at the phosphoglucomutase locus (Pgm) are present at polymorphic frequencies in natural and in laboratory populations of Drosophila melanogaster.
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  • 37
    ISSN: 1573-4927
    Keywords: sepiapterin synthase ; variegation ; purple ; Drosophila melanogaster ; pteridine eye pigments ; drosopterin
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A variegated position effect on the autonomous gene, purple, has been studied enzymologically in Drosophila melanogaster. Sepiapterin synthase, the enzyme system associated with pr +, was examined for activity in different developmental stages of the fly. The results indicate that T(Y:2) pr c5, cn/prc4 cn flies (flies in which pr + has been translocated and which exhibit variegation) have a reduced amount of enzyme activity as compared with both Oregon-R and pr 1 flies. This reduction in activity was not found in larval stages, which suggests that the inactivation process probably occurs in late larval or early pupal stages. The phenotype of the variegated adult has white eyes with red-colored spots and patches where drosopterins occur. The phenotype of the fly carrying the translocation is modified by the presence of additional Y chromosomes. This extends the observation from other systems that extra heterochromatin acts to suppress the variegated position effect. The advantages of studying the variegation by measuring enzyme activity, as well as the phenotypic expression, are several; for example, the developmental time at which variegation occurs may be estimated even though drosopterin synthesis is not occurring.
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  • 38
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    Biochemical genetics 17 (1979), S. 1131-1144 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; enzyme polymorphism ; G6PD ; 6PGD ; enzyme activity
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The electrophoretic variants of G6PD and 6PGD isolated from the Bogota Drosophila melanogaster population were characterized developmentally and biochemically. Changes in in vitro enzyme activity during development were comparable to those found for other dehydrogenases: an increase in the larval and adult stage and a decrease in the pupal stage. During the whole life cycle the “S” enzyme of both loci showed a higher activity than the “F” enzyme. MgCl2 had a stimulating effect on the activity of both enzymes whereas their heat stability was decreased. The allozymes of 6PGD had different Vmax's but were comparable with respect to Km values, pH optimum, and stability at 45 C. the allozymes of G6PD showed different Vmax's and differed in stability at 35 C, but had similar Km values and pH optima. As the difference in stability was probably due to differences in molecular structure of the allozymes, the differences in activity found at high pH and high MgCl2 concentration were most probably due to this difference in stability.
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  • 39
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    Biochemical genetics 13 (1975), S. 603-613 
    ISSN: 1573-4927
    Keywords: transport mutants ; eye color mutants ; kynurenine ; Drosophila melanogaster ; Malpighian tubules
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Kynurenine-H 3 transport and conversion to 3-hydroxykynurenine were studied in organ culture using the Malpighian tubules and developing eyes from wild type and the eye color mutants w, st, 1td, ca, and cn of Drosophila melanogaster. Malpighian tubules from wild type have the ability to concentrate kynurenine and convert it to 3-hydroxykynurenine. The tubules from w, st, 1td, and ca are deficient in the ability to transport kynurenine, as are the eyes of the mutants w, st, and 1td. This defect in kynurenine transport provides a physiological explanation for the phenotypic properties of the mutants. The relationship of these measurements to previous observations on these eye color mutants is discussed and the transport defect hypothesis is consistently supported. We have concluded that several of the eye color mutants in Drosophila are transport mutants.
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  • 40
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; GTP cyclohydrolase ; pteridine biosynthesis ; development ; mutants
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The enzyme guanosine triphosphate cyclohydrolase (GTP cyclohydrolase), which in bacteria is known to be the first enzyme in the biosynthetic pathway for the synthesis of pteridines, has been discovered in extracts of Drosophila melanogaster. Most of the enzyme (80%) is located in the head of the adult fly. An analysis of enzyme activity during development in Drosophila has revealed the presence of a relatively small peak of activity at pupariation and a much larger peak that appears at about the time of eclosion. Enzyme activity declines rapidly as the fly ages. Analyses for the production of the typical pteridine pigments of Drosophila have indicated that the small peak of GTP cyclohydrolase activity evident at pupariation coincides with the appearance of isoxanthopterin, sepiapterin, and pterin, and the larger peak at eclosion roughly corresponds to the accumulation of drosopterin as well as to the appearance in larger amounts of pterin and sepiapterin. These observations strongly suggest that in Drosophila, like bacteria, GTP cyclohydrolase is involved in the biosynthesis of pteridines. Analyses of a variety of zeste mutants of Drosophila melanogaster have shown that these mutants all contain GTP cyclohydrolase equal approximately to the amount found in the wild-type fly. These observations do not support the suggestions made by Rasmusson et al. (1973) that zeste is the structural locus for GTP cyclohydrolase.
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  • 41
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    Biochemical genetics 16 (1978), S. 333-342 
    ISSN: 1573-4927
    Keywords: β-hydroxy acid dehydrogenase ; chromosome ; dosage compensation ; Drosophila melanogaster
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A mutant Had nl was induced in Drosophila melanogaster and found to be deficient in β-hydroxy acid dehydrogenase. This mutation was utilized to study the genetics and physiological expression of Had +. Had+ was mapped to the X chromosome at 54.4 and seems to be the structural gene for the enzyme. Enzyme activity in male and female flies indicates that the gene shows both dosage compensation independent from dose effect and differential activity during ontogeny. Electrophoretic mobility data indicate that the enzyme is a dimer which forms by random association of subunits. The fact that the mutant shows no detrimental effect implies that the enzyme is dispensable, at least under laboratory conditions. The biological and technical implications of this gene-enzyme system are discussed.
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  • 42
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; 6-phosphogluconate dehydrogenase ; Pgd n lethal alleles ; rescue by dietary supplements ; hexose monophosphate shunt
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The genetic rescue of Pgd n lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgd n lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgd n /Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.
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  • 43
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    Biochemical genetics 17 (1979), S. 1-22 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; esterase 6 ; allozymes ; biochemical properties
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Biochemical properties of esterase 6 in Drosophila melanogaster were investigated using partially purified preparations from three genotypes, 1/1, 1/2, and 2/2. The molecular weight of the enzyme is estimated to be about 90,000, and treatment with sodium dodecylsulfate cleaves the enzyme into four units with a molecular weight of about 22,000. The activity toward 28 naturally occurring esters was assayed and shown to vary considerably with substrate, the 1/1 preparation having in general higher activity than 1/2 and 2/2, which were very similar. Heat sensitivity, the effect of metal ions, and the effects of the presence or absence of an end product were also studied. The differences demonstrated between allozymes would allow considerable scope, under appropriate conditions, for differential selection to operate between genotypes.
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  • 44
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    Keywords: Drosophila melanogaster ; phosphoglucomutase ; polymorphism ; enzyme kinetics
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Phosphoglucomutase (PGM) of adult stage in Drosophila melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB but shows the same pH optimum, equal dependence on Mg2+, and identical molecular weight. There is no significant kinetic difference between the two allozymes at the optimum pH value, but at pH 6.0 the K m value for glucose-1,6-diphosphate of PGMB is significantly higher than that of PGMA. This difference might explain the observed selective advantage of the Pgm A allele in population studies.
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  • 45
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; alcohol dehydrogenase ; enzyme biological activity ; toxicity of alcohols
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The toxicity of the first eight primary alcohols and of four secondary alcohols was compared in a wild-type strain (having active ADH) and an ADH-negative mutant. Differences between lc 50 measured in the two strains allowed an evaluation of the biological activity of the enzyme. In vitro, ADH is mainly active on secondary alcohols, while in vivo its main role is the detoxification and metabolism of ethanol. These observations suggest that originally ADH was involved in unknown metabolic pathways and that its utilization in ethanol metabolism could be a recent event.
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  • 46
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    Biochemical genetics 14 (1976), S. 237-243 
    ISSN: 1573-4927
    Keywords: null alleles ; antibody purification ; Drosophila melanogaster ; immunological methods
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Extracts from an acid phosphatase CRM− null mutant of Drosophila melanogaster were used to eliminate contaminating antibodies in a nonspecific preparation of anti-acid phosphatase serum. This method of producing specific antisera makes unnecessary the rigorous purification of an antigen prior to immunization attempts in those cases where CRM− null mutants of the antigen are available. Antisera so prepared could be used for a wide variety of purposes.
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  • 47
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    Biochemical genetics 14 (1976), S. 299-308 
    ISSN: 1573-4927
    Keywords: allozymes ; alcohol dehydrogenase ; Drosophila melanogaster
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Keeping Drosophila cultures at 28 C results in elimination of all minor multiple ADH bands, thought to be due to conformational change. Thus in diploid and triploid adults heterozygous for the Adh F and Adh Salleles, relative staining intensities are found for the three bands which were in conformity with the assumption that both alleles are equally expressed. Among all polymorphic strains derived from natural Central European and Mediterranean populations, the strain +Tüb is unique in that its Adh Fallele is closely linked to a new recessive lethal factor, named 1(2)Stm. All Adh F 1/AdhF 1 pupae are unable to emerge, and die. The lethal effect is obvious 50 hr earlier by retarded eye, bristle, and body wall pigmentation. Although all pupae of the phenotype F die, Adh F allele frequency scarcely seems to be lowered in this natural population.
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  • 48
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    Biochemical genetics 14 (1976), S. 383-387 
    ISSN: 1573-4927
    Keywords: allozymes ; thermostability ; alcohol dehydrogenase ; Drosophila melanogaster
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two Drosophila melanogaster strains, each heterozygous for “fast” and “slow” alleles at the Adh locus, and each having balanced second chromosomes, were found to differ in the apparent thermostability of the slow allozyme. The two strains were crossed, and F1heterozygotes were separated on the basis of the origin of the slow allele. After electrophoresis, the cellulose acetate strips were treated 1 1/2 min at 35 C. The putatively more sensitive allozyme showed a strikingly greater response to heat. These findings further support the conclusion that electrophoretically cryptic allelic differences exist which are expressed in thermostability differences. Further application of this approach has revealed one similar sensitive slow allozyme and three cases of a relatively resistant fast ADH allozyme in wild-caught flies.
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  • 49
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    Keywords: Drosophila melanogaster ; 6-phosphogluconolactonase ; hexose monophosphate shunt ; Pgd n Zw n mutants
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Using a double mutant strain, Pgd n Zw n , we have developed an assay for 6-phosphogluconolactonase activity and have demonstrated its occurrence in adult Drosophila melanogaster.
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  • 50
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    Biochemical genetics 17 (1979), S. 97-104 
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; form II RNA polymerase initiation sites ; chromomeres
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The in vitro incorporation of γ-32P-labeled nucleoside triphosphates into RNA by Drosophila melanogaster form II RNA polymerase from template sites which afford protection from the initiation inhibitor, polyriboinosinic acid (poly [I]), is used as a method for enumerating a specific class of transcription initiation sites on D. melanogaster DNA. Such sites number about 4000 per haploid genome for D. melanogaster. This value is in good agreement with the number of functional genetic units in the D. melanogaster genome as determined by classical cytogenetics.
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  • 51
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; Malpighian tubules ; purine transport ; eye color mutants ; riboflavin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Uptakes of guanine into Malpighian tubules of wild-type Drosophila and the eye color mutants white (w), brown (bw), and pink-peach (p p) have been compared. Tubules for each of these mutants are unable to concentrate guanine intracellularly. The transport of xanthine and riboflavin is also deficient in w tubules. The transport of guanosine, adenine, hypoxanthine, and guanosine monophosphate is similar in wild-type and white Malpighian tubules. These data and other information about these mutants make it likely that these pteridine-deficient eye color mutants do not produce pigments because of the inability to transport a pteridine precursor. This view supports the hypothesis that mutants which lack both pteridine and ommochromes do so because precursors to both classes of pigments share a common transport system.
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  • 52
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    Biochemical genetics 13 (1975), S. 263-271 
    ISSN: 1573-4927
    Keywords: allozymes ; α-glycerophosphate dehydrogenase ; Drosophila melanogaster
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract On the basis of band staining intensities in electrophoretic runs of single flies homozygous and heterozygous for two alleles at the autosomal locus for GPDH, F allele activity is believed to be 8% lower than S allele activity. Indeed, the intensity distribution in the patterns of FSS and FFS triploid females shows that both are not equally expressed. On a per fly or live weight basis, females with two and three doses of the Gpdh gene show bands with equal staining intensity, thus exhibiting a dosage effect when GPDH activity is estimated on a per cell basis.
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  • 53
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; enzyme variation ; alcohol dehydrogenase ; electrophoretically identical alleles
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A new variant of alcohol dehydrogenase (ADH 71k) was found in a laboratory stock of Drosophila melanogaster. ADH in this stock had the same electrophoretic mobility as the F variant both on acrylamide and on agar. Activity levels were similar to the levels in F flies at temperatures between 15 and 25 C. But while ADH F enzyme is inactivated rapidly at 40 C, ADH 71k is still active. Also, ADH S is not inactivated at this temperature, but has a far lower activity per fly than ADH 71k. Genetic analysis showed that the new variant is an allele of the Adh locus.
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  • 54
    ISSN: 1573-4927
    Keywords: electrophoresis ; alcohol dehydrogenase ; Drosophila melanogaster ; isozymes ; genetic variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Adult Drosophila melanogaster flies collected from populations broadly dispersed over ecological and geographic strata of North Carolina, and over a period of 4 years, were analyzed for alcohol dehydrogenase phenotypes by gel electrophoresis. Gene frequencies in spring-summer-fall field collections were remarkably stable over all strata. Two winter collections exhibited contrasting gene frequency changes. In one case the results are interpreted in terms of long-distance migration from Florida, while the other is explicable by assignment of a causal role to environmental factors which accompany the winter season.
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  • 55
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    Biochemical genetics 16 (1978), S. 769-775 
    ISSN: 1573-4927
    Keywords: hidden variation ; α-GPDH ; Drosophila melanogaster
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The level of hidden variation in populations of Drosophila melanogaster at the Gpdh + locus was determined by thermal stability studies of the protein. The results indicate a lack of variation using these methods both in and between the two common electrophoretic variants. It is suggested that α-GPDH is conserved in primary structure, which may be related to its critical role in flight muscle metabolism.
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  • 56
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    Biochemical genetics 16 (1978), S. 855-865 
    ISSN: 1573-4927
    Keywords: kynurenine hydroxylase ; cinnabar locus ; EMS mutagenesis ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A study was undertaken to isolate mutations affecting the temporal appearance of kynurenine hydroxylase in Drosophila melanogaster. Such mutations, lacking or having reduced enzyme activity at the larval or pupal stage only, could represent changes in regulatory functions. Mutagenesis was carried out using EMS. Potential mutations were isolated from mass F1 cultures. The screening of large numbers of individuals was made possible by the use of the mutant red, which allowed visual classification for the presence or absence of the enzyme at both stages. From a series of six mutagenesis experiments 111,561 chromosomes were tested, and 122 phenotypically mutant F1 individuals were found. From these, 38 inheritable mutations were isolated which, by phenotypic observation, lacked or had reduced enzyme activity at the larval and pupal stages. Assay of enzyme activity levels in several of the mutants confirmed the phenotypic data. All of the 27 mutations that could be tested further are recessive and behave as cinnabar alleles. Complementation tests were performed between these 27 mutant stocks, and no complementation in the production of eye color has been seen between the mutants examined. When extended collection periods were used, a significantly higher percentage of inheritable mutations was isolated from the first 3 days of the screen. Over 80% of the F1 phenotypic mutants could be classified as mosaics, which indicates that cinnabar can be autonomous under certain conditions. The failure to isolate mutations in possible regulatory function is discussed.
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  • 57
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    Biochemical genetics 17 (1979), S. 149-158 
    ISSN: 1573-4927
    Keywords: xanthommatin synthesis ; scarlet mutants ; Drosophila melanogaster ; temperature-sensitive mutants
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Six new EMS-induced scarlet mutants were selected. Four of these were partially pigmented, with xanthommatin levels ranging from 12% to 45% of normal. In one (st 754ts), pigment production was temperature sensitive; the level of xanthommatin changed from less than 10% of normal at 29 C to more than 70% at 18 C. In all of the new mutants tested, the level of early pupal 3-hydroxykynurenine was as low as low as that in st 1. Thus reduced larval accumulation of this metabolite also appears to be a characteristic feature of scarlet mutants. Temperature-pulse and temperature-shift experiments were carried out with st 754ts to determine the temperature-sensitive period for the scarlet gene during development. The major sensitive period commenced prior to the onset of pigmentation and was over before adult emergence. Thus the initiation of xanthommatin synthesis is not brought about by the activation of the scarlet gene. In similar experiments carried out with a temperature-sensitive white mutant (w bl), a similar temperature-sensitive period was obtained.
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  • 58
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; biopterin synthesis ; oxidation of dihydropterins
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    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An enzyme which has been named “biopterin synthase” has been discovered in Drosophila melanogaster. This enzyme, which has been purified 200-fold from extracts of Drosophila, catalyzes the conversion of sepiapterin to dihydrobiopterin, or oxidized sepiapterin to biopterin. The K m values for the two substrates are 63 µm for sepiapterin and 10 µm for oxidized sepiapterin. NADPH is required in this enzymatic reaction. An analysis of enzyme activity during development in Drosophila indicates a correlation between enzyme activity and biopterin content at various development stages. Another enzyme, called “dihydropterin oxidase,” was also discovered and partially purified. This enzyme catalyzes the oxidation of dihydropterin compounds to the corresponding pterin compounds. For example, sepiapterin (a dihydropterin) is oxidized to oxidized sepiapterin in the presence of this enzyme. The only dihydropterin that has been tested that is not a substrate for this enzyme is dihydroneopterin triphosphate, the compound thought to be a precursor for all naturally occurring pterins and dihydropterins. Since the action of dihydropterin oxidase is reduced significantly when the concentration of oxygen is very low, it is likely that this enzyme uses molecular oxygen as the oxidizing agent during the oxidation of dihydropterins. Neither NAD+ or NADP+ is required. In the presence of the two enzymes dihydropterin oxidase and biopterin synthase, sepiapterin is converted to biopterin. However, in the presence of biopterin synthase alone, sepiapterin is converted to dihydrobiopterin.
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  • 59
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    Theoretical and applied genetics 55 (1979), S. 231-238 
    ISSN: 1432-2242
    Keywords: Drosophila melanogaster ; Scute locus ; Maps ; Operon-like model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The functional expression of 12 scute alleles in homozygotes and compounds of Drosophila melanogaster at 14°, 22°, 30°C is analysed. Based on the data obtained, linear maps for bristles and mutations are built. The basic features of the maps, clustering and polarity, are invariable with respect to temperature, scute gene dosage and cross direction. In addition local dominance of the norm over bristle reduction was produced by the scute mutation; different types of complementation reactions were established for each bristle. The gene scute is treated as an operon-like system, composed of 3–4 cistrons with each controlling the formation of bristles on a particular region of the fly's body. This model argues well with the structure of maps constructed and implies a post-translational level of initial events of bristle-formation process.
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  • 60
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    Medical & biological engineering & computing 15 (1977), S. 11-17 
    ISSN: 1741-0444
    Keywords: Haemodynamics ; Modelling ; Pulsatile flow
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    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The displacement relationships describing the deformation of an elastic vessel under excess internal pressure which are derived from different theories of elasticity are compared. The main result of the comparison is that theories which take account of the thickness of the wall of the vessel produce a significantly better representation than those theories which treat the wall as a membrane. The classical and statistical theories of thick-walled tubes result in complicated pressure-radius relationships. It is shown that there is little difference between the results of the more exact theories and those for a thin membrane corrected by means of a simple thickness factor. A review of the different theories is necessary to decide which pressure-displacement relationship to apply as an approximation for the elastic properties of arteries. An indication is given of the manner in which the relationship is used in numerical computations. In Part 2 the experimental determination of the pressure-radius relationship for a rubber tube is described. The results are in agreement with the conclusions of the comparison of theoretical treatments in Part 1.
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  • 61
    ISSN: 1741-0444
    Keywords: Haemodialysis ; Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire On a entrepris un traitement de dialyse sur malade afin d’étudier les phénomènes dynamiques de concentration des déchets (urée et créatinine) et de pression f.s.c. sur un malade rénal au cours du cycle complet des périodes de pré-dialyse, dialyse et post-dialyse. Les concentrations pour les variables du traitement de dialyse sont prédites par le modèle à cinq compartiments de Dedrick et Bischoff, elles comprennent la fréquence et la durée du traitement, la vitesse de formation d’urée chez le malade et la vitesse d’élimination de l’urée par l’appareil de dialyse. Les résultats montrent que la pression f.s.c. baisse au cours de la période de pré-dialyse, augmente rapidement en début de traitement puis se rapproche (sans cependant la dépasser) petit à petit de la valeur normale. L’analyse démontre ainsi qu’une augmentation significative de la pression f.s.c. au cours de l’hémodialyse rapide n’est pas dûe aux changements de concentration de l’urée du cerveau étant mis en valeur par les études de pathophysiologie du syndrome de déséquilibre de dialyse de Arieff et Massry. Si l’augmentation importante et brusque de la pression f.s.c. (immédiatement après le début du traitement) n’est pas désirable, on recommande de commencer la dialyse au point de la vitesse minimale d’élimination de l’urée. Plus tard une hausse lente de la vitesse d’élimination peut s’entreprendre et la fréquence du traitement peut être augmentée afin de limiter la durée des séances d’un traitément.
    Abstract: Zusammenfassung Die Dialysebehandlung von Patienten wurde analysiert, um die Dynamik von metabolischen Abfallstoffkonzentrationen (Harnstoff und Kreatinin) und den CSF-Druck eines Patienten im Laufe des gesamten Zyklus von Vordialyse, Dialyse und der Zeitspanne nach Dialyse zu untersuchen. Die Konzentrationen werden durch das fünfteilige Modell von Dedrick und Bischoff hinsichtlich der Veränderlichen der Dialysebehandlung vorausgesagt, wie Häufigkeit der Benutzung und Behandlungszeit, die Harnstofferzeugungsrate des Patienten und Harnstoff-klärungsrate des Dialysegerätes. Die Ergebnisse deuten an, daß der CSF-Druck in der Zeit vor Dialyse abnimmt, am Anfang der Behandlung stark zunimmt und dann seinen Normalwert allmählich wieder erreicht (aber nicht übersteigt). Die Analyse zeigt daher, daß der signifikante Anstieg des CSF-Drucks bei schneller Hämodialyse nicht durch Änderungen der Harnstoffkonzentrationen im Gehirn verursacht wird, was durch die pathophysiologischen Untersuchungen des Dialyse-Labilität-Syndromsvon, Arieff und Massry bestätigt wird. Wen der große plötzliche Ansteig des CSF-Drucks (unmittelbar nach Anfang der Behandlung) nicht gewünscht wird, wird empfohlen, die Dialyse dann einzuleiten, wenn die niedrigste Harnstoffklärungsrate gegeben ist. Später könnte eine allmähliche Erhöhung der Klärungsrate vorgesehen werden, und die Häufigkeit der Behandlung kann gesteigert werden, um die Dauer einer Behandlung zu kürzen.
    Notes: Abstract A patient-dialysis treatment analysis has been performed, to study the dynamics of metabolic waster concentrations (urea and creatinine) and c.f.s. pressure in a renal patient during the entire cycle of pre-dialysis, dialysis and post-dialysis periods. The concentrations have predicted by the five compartment model of Dedrick and Bischoff, for the dialysis treatment variables, such as frequency of use and treatment time, urea generation rate of the patient and urea clearance rate of the dialyser. The results indicate that the c.f.s. pressure decreases during the pre-dialysis period, increases abruptly at the beginning of the treatment and then approaches (but does not overshoot) its normal value gradually. The analysis thereby shows that the significant rise in c.f.s. pressure in the rapid haemodialysis is not due to changes in the urea concentrations in the brain, which is validated by the pathophysiology studies of dialysis disequilibrium syndrome by Arieff and Massry. If the large abrupt rise in c.f.s. pressure (immediately following the start of treatment) is not desirable, it is recommended that the dialysis be started at the lowest urea clearance rate. Later a gradual increase in the clearance rate may be provided and the treatment frequency can be increased, in order to limit the duration of a treatment session.
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  • 62
    ISSN: 1741-0444
    Keywords: Haemodynamics ; Modelling ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Les malades souffrant d'un insuffisance rénale terminale présentent souvent une hypertension liée au mécanisme eau/sodium. Cette étude utilise un modèle mathématique pour établir les relations éventuelles entre les valeurs des volumes d'eau et autres variables hémodynamiques et le comportement du système régulateur de la pression sanguine.
    Abstract: Zusammenfassung Patienten mit Nierenversagen im Endstadium zeigen oft eine wasser/natriumabhängige Hypertension. Diese Studie bedient sich eines mathematischen Modells, um ein etwa bestehendes Verhältnis zwischen den Werten der Wasservolumen und anderer hämodynamischen Veränderlichen und dem Verhalten des Blutdruckregelsystems festzustellen.
    Notes: Abstract Patients with end-stage renal failure often exhibit a water-sodium dependent hypertension. This study employed a mathematical model to establish possible relationships between water volume and other haemodynamic variables and the behaviour of the blood-pressure regulating system.
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    Medical & biological engineering & computing 15 (1977), S. 611-617 
    ISSN: 1741-0444
    Keywords: Haemodynamics ; Modelling ; Pulsatile flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Est décrit un modèle mathématique pouvant être utilisé pour calculer la circulation sanguine dans une artère normale à partir de pressions mesurées en deux points différents. Les équations établissant le mouvement d'un fluide dans un tube élastique sont simplifiées mais suffisamment réalistes pour pouvoir être appliquées à la circulation artérielle. On choisit une solution numérique pour les équations dont la moyenne a été établie pour chaque section du tube; ces équations sont résolues par la méthode des différences finies. On choisit un terme de substitution pour la constante de frottement qui ne peut pas être exprimée avec exactitude par ces équations différentielles partielles non linéaires. On démontre combien les résultats sont sensibles aux changements de la constante de frottement. On présente une méthode qui établit le frottement sur les parois grace à une approximation linéaire mais qui, dans le cadre des limites imposées, utilise néanmoins une valeur correcte en amplitude comme en phase. Les effects longeur-entrée sont corrigés. Les propriétés des parois sont représentées par un rapport pression/rayon élaboré à partir d'un précédent ouvrage écrit par les auteurs (Taylor etGerrard, 1976). L'utilisation du modèle est illustrée par l'emploi de données expérimentales citées parStreeter et al. (1963). La solution est parfaitement conforme aux résultats expérimentaux.
    Abstract: Zusammenfassung Ein amthematisches Modell wird beschrieben, mit dessen Hilfe man den Blutdurchflug in einer normalen Arterie aus dem an zwei verschiedenen Punkten gemessenen Druck berechnen kann. Die Gleichungen der Flüssigkeitsbewegung in einem elastischen Schlausch sind zwar vereinfacht, aber ausreichend der Wirklichkeit entsprechend, um auf die Arterien angewendet werden zu können. Man entscheidet für eine numerische Lösung der Gleichungen im Durchschnitt der Schlauchabschnitte, und die Gleichungen werden durch die Methode der endlichen Differenzen gelöst. Der Reibungsausdruck, der in diesen nicht-linearen partiellen Differenzial-gleichungen nicht genau bestimmt werden kann, wird substituiert. Die Sensitivität der Ergebnisse gegenüber Änderungen des Reibungsausdruckes wird aufgezeigt. Eine Methode wird vorgeführt, die die Hautreibung auf einem Linearnäherungswert begründet; innerhalb dieser Grenzen verwendet sie, was Größe Phase betrifft, einenrichtigen Wert. Für Eintrittslängeneffekte wird eine Eerichtigung vorgenommen. Die Eigenschaften der Arterienwand werden durch ein Druck/Radiusverhältnis dargestellt, das in früheren Artikeln von den Verfassern entwickelt wurde (Taylor undGerrard 1976). Die Verwen, dung dieses Modells wird anhand von Versuchsdaten, die vonStreeter u.a. (1963) angeführt wurden, dargelegt. Die Losung laßt sich vorteilhaft mit Versuchsergebnissen vergleichen.
    Notes: Abstract A mathematical model is described which can be used to calculate blood flow in a normal artery from pressures measured at two separated points. The equations of motion of fluid in an elastic tube are simplified but sufficient realism is retained for the application to arterial flow. A numerical solution to the equations averaged over each section of the tube is chosen and these equations are solved by the method of finite differences. A substitution is made for the frictional term which cannot be expressed exactly in these nonlinear partial differential equations. The sensitivity of the results to changes in the friction term is demonstrated. A method is presented which bases the skin friction on a linear approximation, but within this limitation uses a value which is correct in magnitude and phase. A correction is made for entrace-length effects. The wall properties are represented by a pressure-radius relationship developed from previous work by the authors (Taylor and Gerrard, 1976). The use of the model is illustrated by using experimental data quoted by Streeteret al. (1963). The solution compares favourably with the experimental results.
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    Medical & biological engineering & computing 16 (1978), S. 90-97 
    ISSN: 1741-0444
    Keywords: Modelling ; Physiological cardiac pacemaker ; Pulse-frequency modulator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Une correspondance biologique fondée sur un modulateur nous permet d’utiliser les techniques mises au point dans la théorie des communications pour estimer avec quelle justesse le système transmet l’information et réciproquement avec quelle justesse on peut évaluer le signal de contrôle à partir des signes sortants. Des études précédentes ont tiré parti des similitudes existant entre l’activité du système nerveux et un programme de modulation du pouls connus sous le nom de modulation intégrale de la fréquence du pouls (m.i.f.p.). Récemment (Hyndman and Mohn, 1975), le m.i.f.p. a été amélioré par l’adjonction d’une période de repos visant à imiter le stimulateur cardiaque. Dans l’étude actuelle, le m.i.f.p. a été adapté une fois encore pour inclure la variation observée dans le seuil du stimulateur, le potentiel de membrane et la période refractaire, et pour inclure également une évaluation convenable des effets dûs à l’interface stimulateur/système nerveux. Nous avons étudié aussi la manière dont ces sources de variabilité influent sur l’activité du système simulé. L’étude conclut que le filtrage passe-bas de l’information intermittente R-R permettra d’estimer correctement le signal de contrôle nerveux et que le modèle de modulation de la fréquence du pouls est un procédé applicable au système cardiaque et aux autres systèmes physiologiques.
    Abstract: Zusammenfassung Ein auf einem Modulator beruhendes biologisches Analogsystem ermöglicht die Anwendung der in der Kommunikationstheorie verwendeten Technik, um zu schätzen, wie gut das System Information überträgt und wie gut man von der Ausgabe auf das Kontrollsignal schließen kann. Frühere Arbeiten erschöpften die Übereinstimmung von Nervenaktivität und einem Pulsmodulationsschema, das unter der Bezeichnung integrale Pulsfrequenzmoduation (i.p.f.m.) bekannt ist. Vor kurzem (Hyndman und Mohn, 1975) wurde i.p.f.m. durch die Beigabe einer Ruheperiode zum Modell für den Herzschrittmacher entwickelt. Dieser Artikel beschreibt eine weitere Entwicklung, die auch die Schwankungen, die in der Schrittmacherschwelle beobachtet werden, sowie das Membranpotential und die Refraktionsperiode berücksichtigt und die Wirkung der Nerven-Schrittmachergrenzfläche abschätzt. Es wird untersucht, wie diese Schwankungsquellen die Leistung des Simuliersystems beeinflußen. Es ergibt sich, daß die Tiefpaßfiltrierung der R-R-Intervalldaten eine gute Schätzung des Nervkontrollsignals ermöglicht und daß sich das Pulsfrequenzmodulationsmodell auf dieses und andere physiologische Systeme anwenden läßt.
    Notes: Abstract A biological analogue based on a modulator allows one to use the techniques developed in communication theory to estimate how well the system transmits information and, conversely, how well one can estimate the controlling signal from the output. In previous works, the similarities between neural activity and a pulse-modulation scheme known as integral pulsefrequency modulation (i.p.f.m.) were exploited. Recently (Hyndman and Mohn, 1975) i.p.f.m. was adapted by the addition of a dormant period to model the cardiac pacemaker. In the present study, i.p.f.m. is further adapted to include the variability observed in the pacemaker threshold, membrane potential and refractory period, and also to include a reasonable estimate of the effects of the neural-pacemaker interface. How these sources of variability affect the performance of the simulated system is examined. It is concluded that the low-pass filtering of R-R interval data will yield fair estimates of the controlling neural signal and that the pulse frequency-modulation model is applicable to this and other physiological systems.
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    Medical & biological engineering & computing 17 (1979), S. 223-229 
    ISSN: 1741-0444
    Keywords: Metabolic systems ; Modelling
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    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A case study illustrates the application of systems theory to the analysis of data from nonrepeatable experiments with relatively few data points. The specific problem considered is the compartmental modelling in the human of the metabolic pathways of orally-administered methionine using tolerance test data. Attention is restricted to linear models, and concentrates on the determination of parsimonious structures (i.e. with as few parameters as possible) and their physiological interpretation.
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    Medical & biological engineering & computing 15 (1977), S. 564-572 
    ISSN: 1741-0444
    Keywords: Eye ; Modelling
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    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Un modèle mathématique a été réalisé pour déterminer automatiquement l'emplacement d'un type de ruptures rétiniennes détachées. Il s'agit d'un oeil schématique complet tenant compte du rayon et du centre de courbure ainsi que de l'indice de réfraction. Le contrôle par ordinateur permet au chirurgien de corriger le site apparent lors du placement d'un implant dans une opération d' agrafage sur la schlérotique. La longueur de l'acc de retombée sur la chroïde, mesurée sur la surface postérieure de la schlérotique en commençant à partir du prolongement de l'axe de vision jusqu'à la rupture rétinienne, et la somme de deux déplacements: un uniquement dû à la géométrie, l'autre à la relaxation de la rétine. Le déplacement géométrique est l'élément essentiel, car la distance maximale de la partie détachée est considérée comme faible comparée à la distance radiale depuis le centre du globe oculaire. La traction de l'humeur vitrée affectant la relaxation rétinienne est remplacée par une traction globale correspondant à une distance chordale observée entre des points extrêmes et la distance du détachement. La rétine est supposée élastiquement homogène et isotrope et est soumise à une traction normale uniforme de sa surface vers l'intérieur. Les déplacements sont prédits à l'aide d'une théorie non linéaire pout les forts déplacements de membrane. Les résultats d'ordinateur représentatif sont donnés pour le méridien vertical.
    Abstract: Zusammenfassung Es wurde ein mathematisches Modell zur automatischen Lokalisierung einer Klasse abgelöster Netzhautrisse konstruiert. Es schließt ein komplettes schematisches Auge mit Krümmungshalbmesser, Krümmungsmittelpunkt und Brechungsindex ein. Die Computer-Steuerung liefert dem Chirurgen Korrekturen von dem augenscheinlichen Sitz für die Anbringung eines Transplantats in einem skleralen Knickverfahren. Die Bogenlänge der Wiederabsetzung auf die Gefäßhaut, gemessen auf der hinteren Fläche der Sklera und beginning von der Verlängerung der Sichtlinie zum Netzhautriß, ist die Summe von zwei Verlagerungen: eine ausschließlich infolge der Geometrie, die andere infolge der Netzhauterholung. Der geometrische Beitrag ist am wichtigsten, weil der Maximalabstant der Ablösung in Vergleich mit dem Radialabstand von der Mitte des Augapfels als gering angenommen wird. Ein hyalines Ziehen, das die Netzhauterholung beeinträchtigt, wird durch eine geschätzte Gesamtstreckung ersetzt, wodurch ein beobachteter chordaler Abstant zwischen Extremalpunkten und Abstand der Ablösung befriedigt wird. Die Netzhaut wird als elastisch homogen und isotrop und einer gleichförmigen, normalen Oberflächenziehung nach innen ausgesetzt angenommen. Verlagerungen werden mittels einer nichtlinearen Theorie für große Verlagerungen von Membranen vorhergesagt. Für den vertikalen Meridian werden repräsentative Computer-Ergebnisse vermittelt.
    Notes: Abstract A mathematical model has been constructed for determining automatically the localisation of a class of detached retinal breaks. It includes a complete schematic eye in terms of the radius of curvature, centre of curvature and index of refraction. Computer control provides the surgeon with corrections from the apparent site for placement of an implant in a scleral buckling procedure. The arc length of settling back onto the choroid, measured on the posterior surface of the sclera and starting from the extension of the line of sight to the retinal tear, is the sum of two displacements, one solely due to geometry, the other to retinal relaxation. The geometric contribution is paramount because the maximum distance of detachment is taken to be small compared with the radial distance from the centre of the globe. Vitreous traction affecting retinal relaxation is replaced by an estimated overall stretch, satisfying an observed chordal distance between extremal points and distance of the detachment. The retina is assumed elastically homogeneous and isotropic and subject to a uniform normal surface traction directed inward. Displacements are predicted by means of a nonlinear theory for large displacements of membranes. Representative computer results are given for the vertical meridian.
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    Medical & biological engineering & computing 17 (1979), S. 199-206 
    ISSN: 1741-0444
    Keywords: Modelling ; Analogue computer ; Kidney
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    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract This report describes a model of the renal perfusion dynamic changes that occur during kidney preservation. The model utilises data from physiological experiments performed in this laboratory as well as from observations reported in the literature. Included in the model are the effects of cellular volume changes due to metabolic variations, vascular distensibility and a hypothesised tissue pressure effect observed under some conditions.
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    Behavior genetics 8 (1978), S. 53-64 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; geotaxis ; chromosome analysis ; dominance effects
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    Topics: Biology , Psychology
    Notes: Abstract Positive and negative geotactic maze behaviors were selected in strains of Drosophila melanogaster, for over 40 generations on 15-unit classification mazes. A chromosome substition analysis of these behaviors was undertaken to determine which of the three major chromosomes is most important in causing the differences in geotactic maze behavior between the divergent strains. By following the appropriate mating scheme, every possible homozygous chromosomal combination of the X, II, and III chromosomes from the geopositive and geonegative strain was produced. Heterozygous combinations were also produced to test for dominance and interchromosomal interactions. The results indicate that all three chromosomes are involved in geotactic behavior. The order of importance was II〉III〉X. Dominance effects were found in females for the X chromosome from the geopositive strain and for the III chromosome from the geonegative strain. No evidence for interchromosomal interactions was uncovered.
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    Behavior genetics 9 (1979), S. 123-128 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; phototaxis ; X chromosome
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    Topics: Biology , Psychology
    Notes: Abstract Strains ofDrosophila melanogaster differ in their phototactic responses to red light (654 nm). Genes located on all three major chromosomes are involved in influencing the response, but the X chromosome and third chromosome account for most of the variation in phototaxis.
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    Behavior genetics 9 (1979), S. 129-134 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; D. simulans ; larval feeding behavior ; egg-to-adult viability ; isofemale line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Larval feeding behavior of isofemale lines of the sibling speciesDrosophila melanogaster andD. simulans was investigated. This behavior was measured as the number of cephalopharyngeal retractions of individual larvae per 30 sec period (CPR score) in different generations (G0, G1, and G14). In addition, egg-to-adult viability was estimated in each isofemale line. The results were as follows: (1) In either species, there was variation of CPR score among individuals and among isofemale lines. Although no differences of CPR score were found among experimental groups (generations) and between species, there was a significant difference among isofemale lines. (2) The behavioral trait was stable through generations in each isofemale line. (3) This behavior was correlated with egg-to-adult viability, showing that it is important for the development of the fly.
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    Behavior genetics 9 (1979), S. 209-217 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; D. simulans ; D. pseudoobscura ; pupation height ; geotaxis ; species differences ; selection for pupation height
    Source: Springer Online Journal Archives 1860-2000
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    Notes: Abstract Pupation heights of various natural and laboratory populations ofDrosophila melanogaster, D. simulans, andD. pseudoobscura were observed in the laboratory under conditions of continuous darkness or continuous light. Generally higher mean pupation heights were observed under conditions of darkness.D. melanogaster tended to pupate higher than theD. pseudoobscura populations, andD. pseudoobscura tended to pupate higher thanD. simulans. The order of these species differences was similar whether pupation was measured in light or in darkness. Results of selection for pupation height inD. melanogaster suggest the presence of genetic variation for this character. The possibility that a relationship exists between adult and larval behaviors was explored by measuring the pupation heights of larvae from strains selected for geotactic behavior as adults, and also by measuring geotaxis of adults from strains selected for pupation height.
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    Behavior genetics 9 (1979), S. 257-275 
    ISSN: 1573-3297
    Keywords: sexual behavior ; Drosophila melanogaster ; genetic mosaics ; ontogeny of behavior ; wing vibration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The sex appeal of aDrosophila melanogaster female is defined here as the stimulus (or set of stimuli) which induces wing vibration in courting males. A quantitative measure of sex appeal is the cumulative duration of wing vibration induced by a given female averaged over several consecutive test intervals using different standardized male testers (sex appeal parameter, SAP). By use of SAP, both males and females are found to have the same amount of sex appeal on the first day after eclosion. However, males rapidly lose it by the next day, so that mature males become distinct from females. We report the ontogeny of the male's response to sex appeal. By the SAP method, we also demonstrate that the male's response is dependent on his previous encounter with females. The sex appeal of 287 gynandromorphs was examined in order to localize the sex appeal focus by means of blastoderm fate mapping. Most mosaic flies were classified as either positive (femalelike, with high SAPs) or negative (malelike, with SAPs of zero). Sixteen percent of the gynandromorphs had intermediate levels of SAP, inducing only short vibrations, a response which males rarely give to normal females. Assuming that the gynanders with such intermediate sex appeal must have both female and male foci, distances to the foci from external landmarks were calculated. The center of the focus seems to be an internal structure mapping to the ventroposterior region of the blastoderm fate map, close to the primordia of the anterior sternites. The focus might include a large mesodermal area, but only part of it must have a female genotype for the sex appeal to be expressed. A possible involvement of the fat bodies in production of the sex appeal stimulus is discussed in relation to these findings. Consistent with this conclusion is the fact that females whose abdomens were amputated still retain enough sex appeal to induce male wing vibrations.
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    Keywords: aristal morphology ; Drosophila melanogaster ; artificial selection ; geotaxis ; mating behavior
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    Notes: Abstract The aristae ofDrosophila have been shown to play a role in mating behavior and geotaxis. Two populations ofD. melanogaster were selected for increased and decreased numbers of major aristal branches. Selection was successful and resulted in two lines differing by an average of six aristal branches. Hybridization analyses of selected lines revealed that genes influencing aristal branching are located on both the X chromosome and the autosomes. Polygenic control of aristal morphology is indicated by a gradual response to selection and low realized heritabilities. When selection was relaxed for 19 generations, the number of aristal branches did not revert to the number in the control line. Changes in aristal branching did not appear to have a consistent influence on geotaxis, although there was a tendency for flies with fewer aristal branches to be geonegative. Neither mating speed nor ethological isolation between the two populations was affected by selection. It is concluded that the number of aristal branches inDrosophila is a neutral trait (i.e., not subject to natural selection) under laboratory conditions. Correlations between aristal morphology and behavior found in other selection experiments by previous investigators were likely due to linkage disequilibria.
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    Behavior genetics 9 (1979), S. 407-412 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; oviposition site preference ; substrate temperature ; heritability
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    Topics: Biology , Psychology
    Notes: Abstract Drosophila melanogaster females from a multifemale stock (SC-1) showed strong oviposition site preference (OSP) in a continuous gradient of substrate temperatures (18–31°C). Flies reared at 25°C had an OSP ( $$\bar X$$ ±SE) of 25.2±0.2°C, whereas flies reared at 18°C had an OSP of 23.5±.2°C. Flies reared from egg to adult at one temperature and exposed as adults for 4 days to another temperature had OSPs intermediate between these extremes. This second 4-day exposure seemed to have a greater effect on OSP than the first rearing temperature. Selection experiments failed to produce significant change in mean OSP in eight generations, indicating a low heritability of temperature OSP in this stock.
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    Behavior genetics 9 (1979), S. 425-429 
    ISSN: 1573-3297
    Keywords: random mating ; Drosophila pseudoobscura ; pheromones ; Drosophila melanogaster
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    Topics: Biology , Psychology
    Notes: Abstract Inbreeding, up to 12 generations of single-pair matings, did not cause significant deviation from random mating among two sets of strains inDrosophila pseudoobscura. This contrasts with reports that inbreedingD. melanogaster induces negative assortative mating among lines.
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    Behavior genetics 9 (1979), S. 543-553 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; divergent selection ; locomotor activity ; heritability
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    Topics: Biology , Psychology
    Notes: Abstract Selection for high and low locomotor activity has been applied in two base populations ofDrosophila melanogaster of distinct geographical origin. From each base population a high and a low line were selected, in which anesthesia was performed with ether. In addition, from one of the base populations a high line and a low line were selected under CO2 narcosis. Locomotor activity was measured in an apparatus consisting of rows of 20 tubes in a line. Heritabilitities in the base populations determined in progeny tests were approximately 10%. Divergent directional selection was successful with realized heritabilities of similar value.
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    Keywords: Drosophila melanogaster ; locomotor activity ; mating preference ; sexual isolation ; fertility ; selected lines
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    Notes: Abstract Tests for reproductive isolation between lines selected for locomotor activity were performed. Three sets of selection lines were used, each consisting of lines selected for low and high locomotor activity from the same base population. Females preferred high-activity males in almost every case. However, in one of the sets temporary sexual isolation was found between flies of the high and low lines. This was accompanied in the low-activity females with a higher fertility when they were mated with their own males. After further selection the partial isolation disappeared.
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    Behavior genetics 9 (1979), S. 563-570 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; locomotor activity ; genetic analysis ; X chromosome ; selected lines
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    Topics: Biology , Psychology
    Notes: Abstract Divergent directional selection produced three pairs of lines each consisting of a line with high and a line with low locomotor activity. Reciprocal crosses between the high and low lines of one of these pairs showed that a considerable part of the activity differences was contributed by differences between the X chromosomes. This was confirmed by a substitution of the three large chromosomes, between the low and the high lines. The two large autosomal chromosomes had only minor effects. Interactions between chromosomes were sometimes significant. Low-activity alleles tended to be dominant over alleles for high activity.
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    Behavior genetics 5 (1975), S. 395-404 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; Drosophila simulans ; hybrids ; sexual behavior
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    Topics: Biology , Psychology
    Notes: Abstract Courtship song and mating speed of hybrids betweenDrosophila melanogaster andD. simulans were investigated. The courtship song of hybrid males is identical to that ofD. simulans, suggesting that X chromosome determination, known from the cross betweenD. pseudoobscura andD. persimilis, is also possible here. Wingbeat frequency of hybrids is intermediate between that of the two parents, demonstrating that courtship song and wingbeat frequency are inherited independently of each other. In mating tests, hybrid males court and are accepted byD. simulans females more than hybrid females (presumably because their song is more “acceptable” to the former).D. melanogaster females reject hybrid males. Hybrid females acceptD. melanogaster males readily, hybrids less readily, andD. simulans least.
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    Behavior genetics 6 (1976), S. 161-170 
    ISSN: 1573-3297
    Keywords: behavioral phenotype ; mating speed ; assortative mating ; Drosophila melanogaster ; progeny
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    Notes: Abstract Time to copulation was measured in matings within and between two inbred Drosophilamelanogaster strains, Edinburgh (E) and 6C/L, using groups of one or five flies of each sex. The E males, which mated faster, usually mate with E females, which are less likely to be fertilized and have fewer progeny whose adult viability is lower. Although generally E males mated far faster with E females than did 6C/L males, there was no difference between the males when with 6C/L females. This need not imply any mating discrimination by E females, but only differences between the strains in the use of preening as a general repulsion movement toward other flies. It is suggested that a greater variety of behavioral and other characteristics (the “behavioral phenotype”) should be considered in studies of mating speed and assortative mating, especially where mating speed is being considered as a major component of fitness.
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    Behavior genetics 6 (1976), S. 385-389 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; data analysis ; mating speed ; truncated distributions
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    Notes: Abstract The distribution of mating speeds in wild-typeDrosophila melanogaster is shown to be log normal. The analysis of mating speeds by methods for truncated distributions is validated, and unbiased estimates of the mean mating speed, the variance of mating speed, and the proportion of flies capable of ever mating are produced. In pair matings, not all pairs are capable of copulating, given even a 7-day mating period.
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    Behavior genetics 6 (1976), S. 407-420 
    ISSN: 1573-3297
    Keywords: chemical attractant ; Drosophila melanogaster ; genetics ; olfactory response ; strain difference
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A simple olfactometer was constructed for measuring the responses of adultDrosophila to odoriferous substances, and an index (attractability index, AI) is proposed to evaluate the response. Five strains ofDrosophila melanogaster of different geographic origins were tested for their responses to five chemical attractants: ethyl alcohol, acetic acid, lactic acid, ethyl acetate, andn-butyraldehyde. Statistical analysis has shown that the differences of AI among strains are highly significant for all the odorants except acetic acid and that male flies are, in general, less sensitive than females. The number of flies which were inactive in the olfactometer also varied with strain, sex, and odorant, suggesting the involvement of some other behaviors, and this raises some difficulties in interpreting the heterogeneities of AI. Nevertheless, these results suggest that a considerable amount of genetic variation for olfactory response exists in natural population ofD. melanogaster.
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  • 83
    ISSN: 1573-3297
    Keywords: minority mating advantage ; Drosophila melanogaster ; mating behavior ; male courtship cues ; habituation by female
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Alleles at the brown locus ofDrosophila melanogaster combined with homozygous scarlet provide a useful model to demonstrate minority advantage of males in mating. Heterozygotes with orange (O) eyes equal in numbers to homozygotes with red (R) eyes (10∶10 in both sexes) displayed no bias favoring either eye color, but each eye color was favored when males occurred in a minority ratio (2∶18). In direct observation of single females with equal numbers of males (3∶3) as controls,O males courted less and more slowly thanR males, but females mated with either type without bias. When unequal (4∶1), the minority males were successful at more than twice the frequency expected. Whether successful or not, the minority males did not change their level of courtship, and thus cannot be said to compensate for their frequency in any way. The time between first courtship and mating was less for the minority males than for the majority males. We discard the hypothesis that the minority male will be accepted immediately or ahead of a majority male, because the opposite tended to occur: that if a minority male courted first he was less likely to be successful than if he waited until the majority courted. Our results then are in conformity with the hypothesis that a female samples males and their courtship cues, thus becoming habituated to the majority of the first courting male, but she accepts a male with a cue different from that which she originally detected but avoided. That male is most often the minority.
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  • 84
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; olfactory response ; genetics ; chemical odorants ; odor-specific variant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Homozygous second chromosome lines were extracted from a natural population ofDrosophila melanogaster and tested for their olfactory responses to ethyl acetate. The chromosome lines were highly heterogeneous for this behavior, and the variability was also specific to other esters and ketones such as ethyl propionate, 2-butanone, 2-pentanone, and 3-pentanone. The responses to these odorants negatively correlated with the response to another odorant, lactic acid. A large part of this odorant-specific variation seemed to be controlled by genes located on the right arm of the second chromosome.
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  • 85
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    Behavior genetics 8 (1978), S. 475-479 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; selective breeding ; digging ; pupation site
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The genetics of the digging behavior ofDrosophila melanogaster larvae was studied through selective breeding. Selection for low digging activity was successful, but selection for high digging activity was not. Selection for low and high digging activity affected another behavior, namely the choice of a pupation site. Digging behavior appears to be under polygenic control.
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  • 86
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    Behavior genetics 8 (1978), S. 487-502 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; ebony mutant ; black mutant ; β-alanine ; mating behavior ; aggression ; phenocopy ; dark strains ; light strains ; territorialism ; arena behavior ; spatial isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Effects of β-alanine on mating behavior and aggression were studied inDrosophila melanogaster using the following competitive pairs: (1) homozygous black (b/b) flies, in which β-alanine synthesis is decreased, vs. alanine is blocked vs. wild-type (e +/e+) flies; (2) dark flies, in which β-alanine incorporation is reduced, owing mainly to chromosome 3, vs. light flies collected from the same population as were the dark flies; (3) homozygous black (b/b) flies, in which β-alanine synthesis is decreased, vs. β-alanine-injectedb/b flies, which are phenocopies of wild-type flies. The behavior of mixed-sex groups was studied in a large, illumination-graded observation chamber containing food and in small uniformly illuminated cells also containing food. The relative competitive mating abilities of these types were measured in both experimental conditions. Uninjected black flies, but not injected ones, showed weak and unsteady gait and weak wing extension. In ebony these abnormalities were more extreme. Dark flies did not show these abnormalities. Accelerated sexual maturation was indicated in males by early onset of courtship and enhanced territorial aggression and in females by earliness of mating. Such acceleration was observed in ebony and dark flies, compared with light flies, and among β-alanine-injectedb/b flies competing with uninjected black flies. Ebony males, although maturing earlier than wild-type males, were less successful than wild-type males in mating. This difference was even greater when the flies were all allowed to mature before competing. Ebony females outmated wild-type females. Dark flies outmated light flies, and β-alanine-injectedb/b males outmated uninjected black males, especially in bright light. Ebony flies mated much longer than wild-type flies, and black flies mated slightly longer than injectedb/b flies. There was some spatial isolation of ebony from wild type, dark from light, and β-alanine-injected from uninjectedb/b flies in the illumination-graded observation chamber. Ebony flies more than wild type concentrated near food. Flies were attracted to the current of moist inlet air. They were also attracted to deposited excrement, and males defended such deposits as a mating area, thus showing rudiments of arena behavior in which a mating area away from the oviposition site is defended. Usually, however, the defended area focused on food.
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  • 87
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    Behavior genetics 5 (1975), S. 9-16 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; temperature ; spatial distribution ; geotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The effect of temperature and sex on spatial distribution ofDrosophila melanogaster adults was studied in a specially designed apparatus. It was observed that individuals tend to aggregate in sections of the sphere independently of sex and temperature. Nevertheless, decrease in temperature increase aggregation. The mobility of both males and females indicates a megative geotactic tendency.
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  • 88
    ISSN: 1573-3297
    Keywords: phototaxis ; Drosophila melanogaster ; Drosophila simulans ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The phototactic responses of four recently collected isofemale strains ofDrosophila melanogaster andDrosophila simulans were measured in a light gradient from 590 to 10 lux. High light intensities were preferred by most flies, but a small proportion of flies preferred the lowest light intensity. Based on the strains tested,D. simulans showed greater phototaxis thanD. melanogaster, and within each species variability was found. The niche breadth ofD. melanogaster appears likely to be greater than that ofD. simulans for phototaxis in the light gradient. These results are in general qualitative agreement with earlier results published on dispersal activities from the same populations.
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  • 89
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    Behavior genetics 7 (1977), S. 251-259 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; courtship song ; mutagenesis ; fate mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A mutant Drosophila melanogaster with an aberrant courtship song has been isolated. The interval between pulses and the length of the pulses are increased. The pulses are polycyclic rather than monocyclic. Flight wingbeat and sine song frequency remain unchanged. The mutation is mapped and fate-mapped. The results from the latter investigation are inconclusive.
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  • 90
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    Behavior genetics 7 (1977), S. 433-439 
    ISSN: 1573-3297
    Keywords: Drosophila melanogaster ; larvae ; digging behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The digging behavior of larvae from the following strains ofDrosophila melanogaster was studied: Oregon R-c, taxi, yellow, and vestigial. It was found that the time of stay of preadults in the culture medium, the number of larvae, and the illumination conditions can modify this behavior. The presence of this characteristic depends on the genetic composition of the population: the larvae of each strain used exhibited their own particular pattern of dispersal throughout the culture medium, independent of the experimental conditions under which this behavior was surveyed.
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  • 91
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    Medical & biological engineering & computing 16 (1978), S. 471-482 
    ISSN: 1741-0444
    Keywords: Biomechanics ; Modelling ; Urinary bladder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Cet article présente un modèle décrivant les propriétés passives de la vessie durant cette phase de collecte. Une technique genre “boîte noire” est utilisée. Le système étudié, qui est défini en terme d'une relation pression/volume, est divisé en quatre sous-systèmes out blocs à savoir deux blocs géométriques, un bloc décrivant les propriétés des parois de la vessie en fonction du temps et un bloc décrivant les propriétés en fonction de sa longueur. Les modèles ont été mis au point et testés pour chaque bloc séparément. En ce qui concerne la géométrie, la vessie est décrite comme une sphère à parois épaisses dont les tissus ont un volume constant. La dépendance des propriétés de ces parois en fonction du temps peut être expliquée avec un modèle visco-élastique, tandis qu'on peut montrer que la relation entre les propriétés de ces parois et leur longueur correspond à des modules élastiques qui dépendent des tensions de manière biexponentielle. Les valeurs estimées des paramètres en question ont été obtenues à la suite d'expériences réalisées sur des bandes de vessies obtenues auprès de l'abattoir local. La combinaison des blocs a donné un modèle global des propriétés passives de la vessie dans la phase de collecte. Ce modèle contient quatorze paramètres. La manière classique d'étudier la vessie, qui consiste à la remplir lentement et à mesurer la pression obtenue, donne une relation pression/volume pseudo-statique appelée un cystométrogramme. Le modèle prédit précisément la forme du cystométrogramme. Cependant, l'analyse d'un tel cystométrogramme classique ne nous permet de déterminer que trois paramètres de notre modèle. Une meilleure méthode de mesure consiste à mettre sous tension de manière graduelle (ou presque) la vessie. Cela permet d'obtenir huit paramètres, pourvu que le volume initial de la vessie soit connu, et plusieurs mesures sur une vessie à différentes tensions nous permettent de déterminer dix paramètres. Les résultats obtenus avec cette méthode de mise sous tension par étape sont compatibles avec le modèle.
    Abstract: Zusammenfassung In diesem Artikel wird ein Modell dargestellt, das die passiven Eigenschaften der Harnblase in der Sammelphase beschreibt. Es wird eine Blackbox-Methode angewandt. Das zu untersuchende System, das als ein Druckvolumenverhältnis definiert wird, wird in vier Teilsysteme oder Spalten aufgeteilt, d.h., zwei Geometriespalten, eine Spalte, die die zeitabhängigen Eigenschaften der Blasenwand darstellt, und eine Spalte, in der die längenabhängigen Eigenschaften beschrieben werden. Für jede Spalte wurden getrennte Modelle konstruiert und getestet. In bezug auf die Geometrie wird die Blase als dickwandige Sphäre mit konstantem Gewebevolumen beschrieben. Die Zeitabhängigkeit der Wandeigenschaften kann anhand eines visko-elastischen Modells erklärt werden. Die Längenabhängigkeit der Wandeigenschaften erweist sich als Erzeuger elastischer Moduli, die bi-exponentiell von der Belastung abhängig sind. Schätzungen der zugehörigen Parameterwerte erhielt man aus Experimenten nit Streifen der Harnblase, die man vom örtlichen Schlachthof bezogen hatte. Die Kombination der Spalten ergab ein Gesantmodell der passiven Eigenschaften der Harnblase in der Sammelphase. Durch die klassische Untersuchungsmethode der Harnblase, sie langsam zu füllen und den hierdurch erzeugten Druck zu messen, erhält man ein pseudo-statisches Druckvolumenverhältnis, Zystometrogramm genannt. Das Modell ergibt eine genaue Voraussage des Zystometrogramms. Jedoch kann man durch die Analyse des klassischen Zystometrogramms nur drei Parameter unseres Modells bestimmen. Ein besseres Meßverfahren beruht auf der stufenweisen (oder fast stufenweisen) Belastung der Harnblase. Eine stufenweise Belastung ergibt acht Parameter vorausgesetzt, daß das Anfangsvolumen der Blase bekannt ist. Mehrere Messungen an einer Blase bei verschiedenen Belastungen ermöglichen es uns, zehn Parameter zu bestimmen. Die Resultate der stufenweisen Belastung sind mit dem Modell vergleichbar.
    Notes: Abstract A model is presented that describes the passive properties of the urinary bladder in the collection phase. A black-box approach is used. The system under investigation, which is defined in terms of a pressure-volume relationship, is divided into four subsystems or blocks, namely two geometry blocks, a block describing the time-dependent properties of the bladder wall, and a block describing its length-dependent properties. Models have been developed and tested for each block separately. With regard to geometry, the bladder is described as a thick-walled sphere of constant tissue volume. The time-dependence of the properties of the wall can be explained using a visco-elastic model, and the length dependence of the wall properties is shown to yield elastic moduli which depend biexponentially on strain. Estimates of the value of the parameters involved were obtained from experiments on strips of urinary bladder, obtained from the local slaughterhouse. Combination of the blocks yielded an overall model of the passive properties of the urinary bladder in the collection phase. The model contains 14 parameters. The classical way of investigating the urinary bladder, by filling it slowly and measuring the pressure produced, yields a pseudostatic pressure-volume relationship called a cystometrogram. The model predicts the form of the cystometrogram accurately. However, analysis of a classical cystometrogram enables us to determine only three parameters of our model. A better measurement method is based on stepwise (or almost stepwise) straining of the urinary bladder. One stepwise straining yields eight parameters, provided the initial volume of the bladder is known, and several measurements on one bladder at different strains enable us to determine ten parameters. The results obtained with stepwise straining are compatible with the model.
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  • 92
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    Medical & biological engineering & computing 17 (1979), S. 216-222 
    ISSN: 1741-0444
    Keywords: Metabolic systems ; Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The adequacy of present-day measurement techniques for the compartmental modelling of metabolic systems is investigated using numerical examples and analysis of experimentally-obtained plasma clearance curves. It is concluded that the model parameters obtained are often of questionable accuracy. The situation can be improved by careful monitoring of experimental conditions and judicious spacing of data points on the response curve, but the work shows a clear need for a continuous (or semicontinuous) method of monitoring plasma concentration. To resolve ambiguities between models equally plausible on physiological grounds, it is necessary to monitor the dynamics of internal variables, for example, of the concentration in the liver (which is nowadays possible noninvasively).
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    In:  Amsterdam, Springer, vol. 1, pp. 225, (1-4020-3353-2)
    Publication Date: 2005
    Keywords: Tsunami(s) ; Earthquake risk ; Earthquake precursor: prediction research ; Review article ; Early warning systems (earthquakes, volcanic eruptions, tsunamis etc.) ; Modelling ; NATHAZ ; measurement, ; tsunami ; model, ; data ; assimilation, ; data ; inversion, ; tsunami ; warning, ; tsunameters, ; forecast, ; hazard ; mitigation
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    In:  Corporate, Florida, Springer, vol. Developments in Petroleum Science vol. 15B, no. Publ. No. 12, pp. 9, (3-540-24165-5, XXVI + 228 p.)
    Publication Date: 2006
    Description: This book provides a summary of geodynamic results from Iceland that presently are found in a great number of scientific articles, but have not been collected before in a book
    Keywords: Textbook of geodesy ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Geodesy ; Plate tectonics ; GeodesyY
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    In:  Berlin, Springer, vol. 3, no. ALEX(01)-FR-77-01, AFTAC Contract F08606-76-C-0025, pp. 329, (ISBN: 3-540-27983-0, XII + 238 p., 77 illus., 13 in colour with CD-ROM)
    Publication Date: 2006
    Description: Contents: Data Analysis in Earth Sciences - Introduction to MATLAB - Univariate Statistics - Bivariate Statistics - Time-Series Analysis - Signal Processing - Spatial Data including Digital Elevation Models - Image Processing including Processing and Georeferencing of Satellite Images - Multivariate Statistics; IfGW Uni Potsdam
    Keywords: Data analysis / ~ processing ; Modelling ; software ; Textbook of geophysics ; Statistical investigations ; digital signal analysis (also DSP) ; DSP ; Time series analysis ; Digital elevation model ; geographic ; coordinates ; Mapping ; Toolbox
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    In:  Cambridge, Springer, vol. LXXVIII, no. 2, pp. 125-169, (ISBN: 3-540-42642-6, Approx. 620 p. 30 illus., Hardcover)
    Publication Date: 2006
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Volcanology ; Geodesy ; Global Positioning System ; InSAR ; Textbook of geodesy
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    In:  Amsterdam, 490 pp., Springer, vol. 11, no. Publ. No. 12, pp. 127, (1-4020-4233-7 (hc), 1-4020-4234-5 (sc), X + 413 p.)
    Publication Date: 2006
    Description: Tectonic motion of the Adria microplate exerts a first-order control on the tectonics, geology, seismology, resource distribution, and the geological hazards across a broad zone of south-central Europe and the north-central Mediterranean... This workshop brought together a distinguished international group of scientists working in the peri-Adriatic region to: (1) review research activities and results, (2) share technical expertise, and (3) provide a springboard for future collaborative research on Adria geodynamics. Areas of agreement were identified, as well as remaining areas of debate. In addition, attention focused on important scientific questions and the potential for international and interdisciplinary research in the future
    Keywords: Plate tectonics ; Geodesy ; Tectonics ; Earthquake hazard ; Italy ; Croatia
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    In:  Professional Paper, Perspectives in Modern Seismology, Berlin, Springer, vol. 105, 223 pp., no. 231, pp. 13-30, (ISBN: 3-540-23712-7)
    Publication Date: 2005
    Keywords: Earthquake risk ; Site amplification ; Strong motions ; Earthquake engineering, engineering seismology ; Synthetic seismograms ; NOISE ; Nakamura ; Modelling ; Cologne ; DFNK ; Faecke ; Facke
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    In:  Geo-Information for Disaster Management, Berlin, Heidelberg, New York, Springer, vol. 12, pp. 323-336, (ISBN 3-540-24988-5)
    Publication Date: 2005
    Keywords: Textbook of informatics ; Earthquake hazard ; Earthquake risk ; Tsunami(s) ; Proceedings of a conference ; Earthquake ; Indonesia ; Geodesy
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    In:  Bull., Polar Proj. OP-O3A4, Perspectives in Modern Seismology, London, Springer, vol. 201, no. XVI:, pp. 169-184, (ISBN: 3-540-23712-7)
    Publication Date: 2005
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Geodesy ; Finite Element Method ; Modelling ; Three dimensional ; Seismology ; Early warning systems (earthquakes, volcanic eruptions, tsunamis etc.) ; Bucharest ; Romania ; Earthquake risk
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