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Compartmental modelling based on methionine tolerance test data: a case study

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Abstract

A case study illustrates the application of systems theory to the analysis of data from nonrepeatable experiments with relatively few data points. The specific problem considered is the compartmental modelling in the human of the metabolic pathways of orally-administered methionine using tolerance test data. Attention is restricted to linear models, and concentrates on the determination of parsimonious structures (i.e. with as few parameters as possible) and their physiological interpretation.

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Author notes

  1. R. F. Brown

    Present address: University of Warwick from the University of New South Wales, 2033, Kensington, NSW, Australia

Authors and Affiliations

  1. Inter-University Institute of Engineering Control, Department of of Engineering, University of Warwick, CV4 7AL, Coventry, England

    R. F. Brown, K. R. Godfrey & A. Knell

  2. Warwick Hospital, Warwick, England

    R. F. Brown, K. R. Godfrey & A. Knell

Authors
  1. R. F. Brown
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  2. K. R. Godfrey
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  3. A. Knell
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Brown, R.F., Godfrey, K.R. & Knell, A. Compartmental modelling based on methionine tolerance test data: a case study. Med. Biol. Eng. Comput. 17, 223–229 (1979). https://doi.org/10.1007/BF02440933

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  • DOI: https://doi.org/10.1007/BF02440933

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