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  • pharmacokinetics  (1,499)
  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
  • 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
  • 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
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  • 1
    Publication Date: 2020-11-23
    Description: Abstract: The simultaneous solution of the Planck equation (involving the widely used “dual-band” technique) using two shortwave infrared (SWIR) bands allows for an estimate of the fractional area of the hottest part of an active lava flow (fh), and the background temperature of the cooler crust (Tc). The use of a high spectral and spatial resolution imaging spectrometer with a wide dynamic range of 15 bits (DAIS 7915) in the wavelength range from 0.501 to 12.67 µm resulted in the identification of crustal temperature and fractional areas for an intra-crater hot spot at Mount Etna, Italy. This study indicates the existence of a relationship between these Tc and fh extracted from DAIS and Landsat TM data. When the dual band equation system is performed on a lava flow, a logarithmic distribution is obtained from a plot of the fractional area of the hottest temperature versus the temperature of the cooler crust. An entirely different distribution is obtained over active degassing vents, where increases in Tc occur without any increase in fh. This result indicates that we can use scatter plots of Tc vs. fh to discriminate between different types of volcanic activity, in this case between degassing vents and lava flows, using satellite thermal data.
    Description: Published
    Description: 641–651
    Description: 4V. Processi pre-eruttivi
    Description: JCR Journal
    Description: open
    Keywords: Mount Etna ; remote-sensing ; lava-flow ; degassing vent ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 2
    Publication Date: 2021-01-27
    Description: We report the first combined measurements of the composition and flux of gas emitted from Nyiragongo volcano by ground-based remote-sensing techniques. Ultraviolet spectroscopic measurements made in May/June 2005 and January 2006 indicate average SO2 emission rates of 38 kg s−1 and 23 kg s−1, respectively. Open-path Fourier transform infrared spectroscopic measurements obtained in May/June 2005, January 2006, and June 2007 indicate average molar proportions of 70, 24, 4.6, 0.87, 0.26, 0.11, and 0.0016% for H2O, CO2, SO2, CO, HCl, HF, and OCS, respectively. The composition of the plume was remarkably similar in 2005, 2006, and 2007, with little temporal variation in proportions of CO2, SO2, and CO, in particular, on the scale of seconds or days or even between the three field campaigns that span a period of 24 months. This stability persisted despite a wide range of degassing behaviors on the surface of the summit crater's lava lake (including discrete strombolian bursts and lava fountains) and variations in the SO2 emission rate. We explain these observations by a regime of steady state degassing in which bubbles nucleate and ascend in chemical equilibrium with the convecting magma. Short-term (seconds to minutes) temporal fluctuations in the SO2–HCl–HF composition were observed, and these are attributed to shallow degassing processes.
    Description: Published
    Description: Q02017
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Nyiragongo ; volcanic gas emissions ; FTIR ; DOAS ; remote sensing ; spectroscopy ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
    Publication Date: 2021-07-14
    Description: From 25 November to 2 December 2006, the first active seismic tomography experiment at Stromboli volcano was carried out with the cooperation of four Italian research institutions. Researchers on board the R/V Urania of the Italian National Council of Research (CNR), which was equipped with a battery of four 210- cubic- inch generated injection air guns (GI guns), fired more than 1500 offshore shots along profiles and rings around the volcano.
    Description: DPC/INGV agreement 2004-2006
    Description: Published
    Description: 269-270
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 3.6. Fisica del vulcanismo
    Description: N/A or not JCR
    Description: reserved
    Keywords: Stromboli ; seismic tomography ; air-gun ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.10. Instruments and techniques ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 4
    Publication Date: 2017-04-04
    Description: The recent eruption of Mount Etna (July 2001) offered the opportunity to analyze magma-derived volatiles emitted during preand syn-eruptive phases, and to verify whether their composition is affected by changes in volcanic dynamics. This paper presents the results of analyses of F, Cl and S in the volcanic plume collected by filter-packs, and interprets variations in the composition based on contrasting solubility in magmas. A Rayleigh-type degassing mechanism was used to fit the acquired data and to estimate Henryâ s solubility constant ratios in Etnean basalt. This model provided insights into the dynamics of the volcano. Abundances of sulfur and halogens in eruptive plumes may help predict the temporal evolution of an ongoing effusive eruption.
    Description: -Gruppo Nazionale per la Vulcanologia.
    Description: Published
    Description: 1559
    Description: partially_open
    Keywords: magmatic degassing ; acidic gases ; plume chemistry ; 01. Atmosphere::01.01. Atmosphere::01.01.07. Volcanic effects ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 5
    Publication Date: 2017-04-04
    Description: The Monte Nuovo eruption is the most recent event that occurred at Phlegrean Fields (Italy) and lasted from 29 September to 6 October 1538. It was characterized by 2 days of quasi-sustained phreatomagmatic activity generating pumice-bearing pyroclastic density currents and forming a 130-m-high tuff cone (Lower Member deposits). The activity resumed after a pause of 2 days with two discrete Vulcanian explosions that emplaced radially distributed, scoria-bearing pyroclastic flows (Upper Member deposits). The juvenile products of Lower and Upper Members are, respectively, phenocryst-poor, light-coloured pumice and dark scoria fragments with K-phonolitic bulk compositions, identical in terms of both major and trace elements. Groundmass is formed by variable proportions of K-feldspar and glass, along with minor sodalite and Fe-Ti oxide present in the most crystallized samples. Investigations of groundmass compositions and textures were performed to assess the mechanisms of magma ascent, degassing and fragmentation along the conduit and implications for the eruptive dynamics. In pumice of the Lower Member groundmass crystal content increases from 13 to 28 vol% from the base to the top of the sequence. Products of the Upper Member consist of clasts with a groundmass crystal content between 30 and 40 vol% and of totally crystallized fragments. Crystal size distributions of groundmass feldspars shift from a single population at the base of the Lower Member to a double population in the remaining part of the sequence. The average size of both populations regularly increases from the Lower to the Upper Member. Crystal number density increases by two orders of magnitude from the Lower to the Upper Member, suggesting that nucleation dominated during the second phase of the eruption. The overall morphological, compositional and textural data suggest that the juvenile components of the Monte Nuovo eruption are likely to record variations of the magma properties within the conduit. The different textures of pumice clasts from the Lower Member possibly reflect horizontal gradients of the physical properties (P, T) of the ascending magma column, while scoriae from the second phase are thought to result from the disruption of a slowly rising plug crystallizing in response to degassing. In particular, crystal size distribution data point to syn-eruptive degassing-induced crystallization as responsible for the transition in eruptive style from the first to the second phase of the eruption. This mechanism not only has been proved to profoundly affect the dynamics of dome-forming calc-alkaline eruptions, but may also have a strong influence in driving the eruption dynamics of alkaline magmas of intermediate to evolved compositions.
    Description: Published
    Description: 601-621
    Description: reserved
    Keywords: Phlegrean Fields ; Vulcanian explosion ; Degassing ; Groundmass crystallization ; Eruption dynamics ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.02. Experimental volcanism ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 6
    Publication Date: 2017-04-04
    Description: In this work we present seismological and ground deformation evidence for the phase preparing the July 18 to August 9, 2001 flank eruption at Etna. The analysis performed, through data from the permanent seismic and ground deformation networks, highlighted a strong relationship between seismic strain release at depth and surface deformation. This joint analysis provided strong constraints on the magma rising mechanisms. We show that in the last ten years, after the 1991–1993 eruption, an overall accumulation of tension has affected the volcano. Then we investigate the months preceding the 2001 eruption. In particular, we analyse the strong seismic swarm on April 20–24, 2001, comprising more than 200 events (Mmax = 3.6) with prevalent dextral shear fault mechanisms in the western flank. The swarm showed a ca. NE-SW earthquake alignment which, in agreement with previous cases, can be interpreted as the response of the medium to an intrusive process along the approximately NNW-SSE volcano-genetic trend. These mechanisms, leading to the July 18 to August 9, 2001 flank eruption, are analogous to ones observed some months before the 1991–1993 flank eruption and, more recently, in January 1998 before the February-November 1999 summit eruption.
    Description: Published
    Description: 1469-1487
    Description: partially_open
    Keywords: Ground deformation ; volcano seismology ; Mt. Etna Volcano ; intrusive mechanism ; 04. Solid Earth::04.03. Geodesy::04.03.01. Crustal deformations ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 7
    Publication Date: 2017-04-04
    Description: Sulphur speciation in volcanic gases acts as a major redox buffer, and H2S/SO2 ratios represent a valuable indicator of magmatic conditions and interactions between magmatic and hydrothermal fluids. However, measurement of H2S/SO2 even by direct sampling techniques, is not straightforward. We report here on application of a small ultraviolet spectrometer for real-time field measurement of H2S and SO2 concentrations, using open-path and extractive configurations. The device was tested at fumaroles on Solfatara and Vulcano, Italy, in November 2002. H2S concentrations of up to 220ppmm(400 ppmv) were measured directly above the Bocca Grande fumarole at Solfatara, and H2S/SO2 molar ratios of 2 and 2.4, respectively, were determined for the ‘F11’ and ‘F0’ fumaroles at Vulcano. In comparison with other optical techniques capable of multiple volcanic gas measurements, such as laser and FTIR spectroscopy, this approach is considerably simpler and cheaper, with the potential for autonomous, sustained hightime resolution operation.
    Description: Published
    Description: 1652
    Description: partially_open
    Keywords: Remote monitoring ; Plume chemistry ; sulphur species ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 8
    Publication Date: 2017-04-04
    Description: Measurement of effusion rate is a primary objective for studies that model lava flow and magma system dynamics, as well as for monitoring efforts during on-going eruptions. However, its exact definition remains a source of confusion, and problems occur when comparing volume flux values that are averaged over different time periods or spatial scales, or measured using different approaches. Thus our aims are to: (1) define effusion rate terminology; and (2) assess the various measurement methods and their results. We first distinguish between instantaneous effusion rate, and time-averaged discharge rate. Eruption rate is next defined as the total volume of lava emplaced since the beginning of the eruption divided by the time since the eruption began. The ultimate extension of this is mean output rate, this being the final volume of erupted lava divided by total eruption duration. Whether these values are total values, i.e. the flux feeding all flow units across the entire flow field, or local, i.e. the flux feeding a single active unit within a flow field across which many units are active, also needs to be specified. No approach is without its problems, and all can have large error (up to ∼50%). However, good agreement between diverse approaches shows that reliable estimates can be made if each approach is applied carefully and takes into account the caveats we detail here. There are three important factors to consider and state when measuring, giving or using an effusion rate. First, the time-period over which the value was averaged; second, whether the measurement applies to the entire active flow field, or a single lava flow within that field; and third, the measurement technique and its accompanying assumptions.
    Description: Published
    Description: 1-22
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: JCR Journal
    Description: reserved
    Keywords: Lava ; Instantaneous effusion rate ; Time-averaged discharge rate ; Eruption rate ; Monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 9
    Publication Date: 2017-04-04
    Description: Morphostructural data derived from Lidar (Light detection and ranging) surveys carried out on Mount Etna in 2005 and 2007 are compared with earlier aerophotogrammetric surveys in 1986 and 1998. These data render an unprecedentedly clear and quantitative image of morphostructural and volumetric changes that have affected the summit area of the volcano in the past two decades and permit the production of a new topographic map. The computed volume gain during the 1986–2007 period amounts to 112 ± 12 106 m3, at a mean annual rate of 5.3 106 m3. The comparison of the various surveys furthermore emphasizes the levels of accuracy and resolution of the different techniques applied. The Lidar technology used in 2007 allows production of high-precision maps in near-real-time, facilitating work concerning environmental hazards such as numerical simulations of, e.g., lava flows.
    Description: Published
    Description: L09305
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 1.10. TTC - Telerilevamento
    Description: JCR Journal
    Description: partially_open
    Keywords: Lidar ; Etna ; morphostructural changes ; lava flows ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
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  • 10
    Publication Date: 2017-04-04
    Description: The soil CO2 flux on Mt. Etna as recorded by the ETNAGAS network (an automatic system for measuring soil CO2 flux and meteorological parameters) started to increase strongly about 5 months prior to the onset of the 2004–2005 eruption and decreased a few months before the end of the eruption. Time delays in the occurrences of anomalies in soil CO2 flux at different sites in the geochemical network constrain the relationship between soil CO2 flux distributions and the tectonic framework of Etna volcano. The anomalies observed before the 2004–2005 eruption support the intrusion of new undegassed magma into the upper feeding system of the volcano (〈20 km below sea level). Magma subsequently rose slowly in the volcano conduits, thereby triggering the onset of the 2004–2005 eruption. The time delays in the occurrences of anomalies in combination with spectral analysis indicate the importance of tectonic and volcanotectonic structures in driving the ascent of deep gases within the crust. Moreover, greatest amplitude pulsations of the low-frequency components of the CO2 flux signals were correlated with the paroxystic activities of the 2004–2005 eruption. This study confirms that CO2 flux variation is a useful indicator for volcanic activity in the surveillance of the Mt. Etna and similar basaltic volcanoes.
    Description: Dipartimento Protezione Civile Ministero degli Interni
    Description: Published
    Description: B09206
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: JCR Journal
    Description: reserved
    Keywords: CO2 flux ; Continuous monitoring of soil CO2 flux ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 11
    Publication Date: 2017-04-04
    Description: Volcanic tremor and low frequency events, together with infrasound signals, can represent important precursory phenomena of eruptive activity because of their strict relationship with eruptive mechanisms and with fluid flows through the volcano's feeding system. Important variations of these seismo-volcanic and infrasound signals, recorded at Mt. Etna volcano, occurred both in the medium- and short-term before the eruption, that took place on 13 May 2008. The most significant changes were observed in the frequency content and location of LP events, as well as in volcanic tremor location, that allowed us to track the magma pathway feeding the 2008 eruptive activity. The infrasound showed three different families of events linked to the activity of the three active vents: North-East crater, South-East crater and the eruptive fissure. The seismic and infrasonic variations reported, corroborated by ground deformations variations, help to develop a quantitative prediction and early-warning system for effusive and or explosive eruptions.
    Description: European Union VOLUME FP6-2004-Global-3
    Description: Published
    Description: L18307
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Mt. Etna Eruption ; volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 12
    Publication Date: 2017-04-04
    Description: Active volcanoes produce inaudible infrasound due to the coupling between surface magmatic processes and the atmosphere. Monitoring techniques based on infrasound measurements have been proved capable of producing information during volcanic crises. We report observations collected from an infrasound network on Mt. Etna which enabled us to detect and locate a new summit eruption on May 13, 2008 when poor weather inhibited direct observations. Three families of signals were identified that allowed the evolution of the eruption to be accurately tracked in real-time. Each family is representative of a different active vent, producing different waveforms due to their varying geometry. Several competitive models have been developed to explain the source mechanisms of the infrasonic events, but according to our studies we demonstrate that two source models coexist at Mt. Etna during the investigated period. Such a monitoring system represents a breakthrough in the ability to monitor and understand volcanic phenomena.
    Description: Published
    Description: L05304
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Mt. Etna ; infrasound ; eruption ; volcano monitoring ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 13
    Publication Date: 2017-04-04
    Description: Volcanic gas emissions from fumaroles on the rim of La Fossa crater, Vulcano Island, Italy, were measured simultaneously using direct sampling (for H2O, CO2, total sulfur, HCl and HF), filter packs (for SO2, HCl, HF) and short-path active-mode FTIR measurements (for H2O, CO2,SO2, HCl and HF) in an intercomparison study in May 2002. The results show that Cl/F ratios were in good agreement between all three methods, and that FTIR and direct sampling determined comparable proportions of CO2 and H2O. Amounts of total S observed in direct sampling data were approximately double the amounts of SO2 measured with filter packs and FTIR. This difference could be attributed either to the fact FTIR and filter packs do not measure reduced sulfur species (e.g., H2S) or to sublimation of elemental S upon exit from the fumarole, after collection by direct sampling but before detection with FTIR and filter packs.
    Description: Published
    Description: L02610
    Description: partially_open
    Keywords: volcanic gas techniques ; gas geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 14
    Publication Date: 2017-04-04
    Description: Chemical and isotopic data have been used as geochemical tracers for a genetic characterization of hydrocarbon gases from a total of eleven manifestations located in Eastern and Central-Southern Sicily (Italy). The molecular analysis shows that almost all the samples are enriched in methane (up to 93.2% Vol.), with the exception of four gas samples collected around Mt. Etna showing high mantle-derived CO2 content. Methane isotope signatures suggest that these are thermogenic gases or a mixture between thermogenic gases and microbial gases. Although samples from some mud volcanoes in Southern Sicily (Macalube di Aragona) show isotope signatures consistent with a mixing model between thermogenic and microbial, by combining the molecular compositions (C1/(C2 + C3))and the methane isotope ratios (d13C1), such a process seems to be excluded. Therefore, the occurrence of secondary post-genetic processes should be invoked. Two main hypotheses have been considered: the first hypothesis includes that the gas is produced by microbial activity and altered post-genetically by microbial oxidation of methane, while according to the second hypothesis thermogenic gas have modified their molecular ratios due to vertical migration.
    Description: Published
    Description: L06607
    Description: partially_open
    Keywords: Isotopic composition/chemistry ; Organic geochemistry ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data
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  • 15
    Publication Date: 2017-04-04
    Description: Constraining fluxes of volcanic bromine and iodine to the atmosphere is important given the significant role these species play in ozone depletion. However, very few such measurements have been made hitherto, such that global volcanic fluxes are poorly constrained. Here we extend the data set of volcanic Br and I degassing by reporting the first measurements of bromine and iodine emissions from Mount Etna. These data were obtained using filter packs and contemporaneous ultraviolet spectroscopic SO2 flux measurements, resulting in time-averaged emission rates of 0.7 kt yr 1 and 0.01 kt yr 1 for Br and I, respectively, from April to October 2004, from which we estimate global Br and I fluxes of order 13 (range, 3â 40) and 0.11 (range, 0.04â 6.6) kt yr 1. Observed changes in plume composition highlight the coherent geochemical behavior of HCl, HF, HBr, and HI during magmatic degassing, and strong fractionation of these species with respect to SO2.
    Description: Published
    Description: Q08008
    Description: partially_open
    Keywords: bromine and iodine in volcanic gases ; halogen atmospheric chemistry ; volcanic degassing ; volcanic plumes ; 01. Atmosphere::01.01. Atmosphere::01.01.07. Volcanic effects ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 16
    Publication Date: 2017-04-04
    Description: A new method for extracting dissolved gases in natural waters has been developed and tested, both in the laboratory and in the field. The sampling device consists of a polytetrafluroethylene (PTFE) tube (waterproof and gas permeable) sealed at one end and connected to a glass sample holder at the other end. The device is pre-evacuated and subsequently dipped in water, where the dissolved gases permeate through the PTFE tube until the pressure inside the system reaches equilibrium. A theoretical model describing the time variation in partial gas pressure inside a sampling device has been elaborated, combining the mass balance and ‘‘Solution-Diffusion Model’’ which describes the gas permeation process through a PTFE membrane). This theoretical model was used to predict the temporal evolution of the partial pressure of each gas species in the sampling device. The model was validated by numerous laboratory tests. The method was applied to the groundwater of Vulcano Island (southern Italy). The results suggest that the new sampling device could easily extract the dissolved gases from water in order to determine their chemical and isotopic composition.
    Description: - European Social Fund.
    Description: Published
    Description: Q09005
    Description: partially_open
    Keywords: dissolved gases ; helium isotope ; PTFE membrane ; Vulcano Island ; 03. Hydrosphere::03.02. Hydrology::03.02.04. Measurements and monitoring ; 03. Hydrosphere::03.02. Hydrology::03.02.07. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.11. Instruments and techniques ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 17
    Publication Date: 2017-04-04
    Description: Ground-based measurements of volcanic sulfur dioxide fluxes are important indicators of volcanic activity, with application in hazard assessment, and understanding the impacts of volcanic emissions upon the environment and climate. These data are obtained by making traverses underneath the volcanic plume a few kilometers from source with an ultraviolet spectrometer, measuring integrated SO2 concentrations across the plume’s cross section, and multiplying by the plume’s transport speed. However, plume velocities are usually derived from ground-based anemometers, located many kilometers from the traverse route and hundreds of meters below plume altitude, complicating the experimental design and introducing large flux (can be 〉100%) errors. Here we present the first report of a single instrument capable of (accurate) volcanic SO2 flux measurements. This device records integrated SO2 concentrations and plume heights during traverses. Between traverses, two in-plume SO2 time series are measured from underneath the plume with the instrument, corresponding to zenith and inclined (user-specified angle from vertical in the direction of the volcano) fields of view, respectively. The distance between the points of intersection of the two views with the plume is found on the basis of the determined plume height, and the two signals are cross-correlated to determine the lag between them, enabling accurate derivation of the wind speed. We present flux data (with errors ±12%) obtained in this way at Mt. Etna during July 2004.
    Description: Published
    Description: Q02003
    Description: partially_open
    Keywords: DOAS ; volcanic SO2 emissions. ; 01. Atmosphere::01.01. Atmosphere::01.01.07. Volcanic effects ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 18
    facet.materialart.
    Unknown
    American Geophysical Union
    Publication Date: 2017-04-04
    Description: Explosion-quake seismograms recorded at Stromboli show that seismic phases with a high-amplitude and high-frequency content propagate with a velocity of approximately 330 m/s - the sound speed. The analysis of seismograms, recorded at a distance of 500 m from one of the three active vents, shows for the first onset a low frequency and particle motion characteristics of a p-wave, which loses its longitudinal polarization with the onset of the air-wave. Recording the explosion-quake simultaneously with a microphonewe would ascertain that the high frequency onset coincides with the air-wave's. In order to better understand the seismic wavefield generated by the atmospheric pressure, we performed a controlled source experiment at Stromboli using a seismic gun. Seismograms with the same two phases and particle motions comparable with the volcanic seismic data were obtained. A second experiment demonstrated, that the air-wave propagates at least in the uppermost 1m of the gound. We suggest that the seismic source of the corresponding seismograms is an explosion at the top of the magma column and conclude that the p- and air-waves are both generated in the same point and at the same time.
    Description: Published
    Description: 65-68
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: volcano seismology ; Stromboli ; air wave ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 19
    Publication Date: 2017-04-04
    Description: The persistent occurrence of long period (LP) events at Mt Etna became apparent with the installation of the first fixed broad-band seismic network in late 2003. Repeating similar LP events from Nov. ‘03 to Sept. ‘04 indicate a non-destructive source process. We perform moment tensor (MT) inversions on a stacked high S/N ratio representative LP signal, conducting a grid search for the source geometry and L2-inversion for the source time function. Results indicate a NNW-SSE oriented resonating sub-vertical crack as the most probable source. This result is consistent with deformation and GPS observations. Crucial to this result are constraints imposed by detailed 3D full waveform numerical simulations in a heterogeneous tomographic model with topography, and in particular a detailed assessment of the influence of very near surface velocity structure on LP signals. Pulsating gas injection is hypothesised as the most likely LP trigger.
    Description: Published
    Description: L22316
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Etna volcano ; moment tensor inversion ; LP activity ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 20
    Publication Date: 2017-04-04
    Description: The FLOWGO thermo-rheological model links heat loss, core cooling, crystallization, rheology and flow dynamics for lava flowing in a channel. We fit this model to laser altimeter (LIDAR) derived channel width data, as well as effusion rate and flow velocity measurements, to produce a best-fit prediction of thermal and rheological conditions for lava flowing in a ~1.6 km long channel active on Mt. Etna (Italy) on 16th September 2004. Using, as a starting condition for the model, the mean channel width over the first 100 m (6 m) and a depth of 1 m we obtain an initial velocity and instantaneous effusion rate of 0.3–0.6 m/s and ~3 m3/s, respectively. This compares with field- and LIDAR-derived values of 0.4 m/s and 1–4 m3/s. The best fit between model-output and LIDAR-measured channel widths comes from a hybrid run in which the proximal section of the channel is characterised by poorly insulated flow and the medial-distal section by well-insulated flow. This best-fit model implies that flow conditions evolve down-channel, where hot crusts on a free flowing channel maximise heat losses across the proximal section, whereas thick, stable, mature crusts of ′a′a clinker reduce heat losses across the medial-distal section. This results in core cooling per unit distance that decreases from ~0.02–0.015°C m−1 across the proximal section, to ~0.005°C m−1 across the medial-distal section. This produces an increase in core viscosity from ~3800 Pa s at the vent to ~8000 Pa s across the distal section.
    Description: Published
    Description: L01301
    Description: 3.6. Fisica del vulcanismo
    Description: 3.5. Geologia e storia dei sistemi vulcanici
    Description: JCR Journal
    Description: reserved
    Keywords: Kava Channel ; LIDAR ; thermal modeling ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
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  • 21
    Publication Date: 2017-04-04
    Description: Volcanoes deform as a consequence of the rise and storage of magma; once magma reaches a critical pressure, an eruption occurs. However, how the edifice deformation relates to its eruptive behavior is poorly known. Here, we produce a joint interpretation of spaceborne InSAR deformation measurements and volcanic activity at Mt. Etna (Italy), between 1992 and 2006. We distinguish two volcano-tectonic behaviors. Between 1993 and 2000, Etna inflated with a starting deformation rate of 1 cm yr 1 that progressively reduced with time, nearly vanishing between 1998 and 2000; moreover, low-eruptive rate summit eruptions occurred, punctuated by lava fountains. Between 2001 and 2005, Etna deflated, feeding higher-eruptive rate flank eruptions, along with large displacements of the entire East-flank. These two behaviors, we suggest, result from the higher rate of magma stored between 1993 and June 2001, which triggered the emplacement of the dike responsible for the 2001 and 2002–2003 eruptions. Our results clearly show that the joint interpretation of volcano deformation and stored magma rates may be crucial in identifying impending volcanic eruptions.
    Description: This work was partly funded by INGV and the Italian DPC and was supported by ASI, the Preview Project and CRdC-AMRA. DPC-INGV Flank project providing the funds for the publication fees.
    Description: Published
    Description: L02309
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 1.10. TTC - Telerilevamento
    Description: 3.6. Fisica del vulcanismo
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: partially_open
    Keywords: deformation ; eruptions ; Mt. Etna ; eruptive cycle ; InSAR ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes ; 04. Solid Earth::04.03. Geodesy::04.03.99. General or miscellaneous ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.03. Geodesy::04.03.07. Satellite geodesy ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 22
    Publication Date: 2017-04-04
    Description: The 2002–2003 effusive eruption of Stromboli volcano represents an excellent opportunity to investigate the transition from effusive to explosive activity at an open-conduit basaltic system, when activity migrated from effusive vents, at the base of the craters, to summit explosions. The transition is investigated here through the analysis of very long period seismicity, delay times between infrasonic and thermal onsets of explosions, and SO2 flux recorded during a 1-year period. The synergy of the multiple geophysical observations points to a magma-driven migration of the magma column. Here the increased magma supply at the eruption onset lead to opening of effusive fissures, which draining the magma in the shallow conduit caused the decrease of the magma level. The decrease of the magma supply at the end of the effusion lead to sealing of effusive fissures, upraise of the magma level within the conduit, and reestablishment of explosive activity from the summit vents.
    Description: Unpublished
    Description: 11
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 1.10. TTC - Telerilevamento
    Description: 3.6. Fisica del vulcanismo
    Description: reserved
    Keywords: Stromboli ; SO2 Flux ; Magma column ; Infrasound ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 23
    facet.materialart.
    Unknown
    American Geophysical Union
    In:  “Accepted for publication in (Journal of Geophysical Research). Copyright (2009) American Geophysical Union. Further reproduction or electronic distribution is not permitted.”
    Publication Date: 2017-04-04
    Description: The eruptive episode of Mount Etna’s Southeast Crater (SEC) on 16 November 2006, which culminated with phreatomagmatic explosions and a peculiar volcaniclastic flowage event, is the subject of different interpretations. Behncke (2009) and Behncke et al. (2008, 2009), interpret the explosions as resulting from mixing of flowing lava with fluid-saturated, hydrothermally altered rock, and describe the resulting flow as a low-temperature (but potentially deadly) pyroclastic density current (PDC). Norini et al. (2009) speak of gravity-induced flank collapse affecting the SEC cone, leading to the emplacement of a landslide (or debris avalanche) deposit. Finally, Ferlito et al., commenting our recent work (Behncke et al., 2009), re-propose their earlier (2007) scenario of a shallow intrusion from the SEC conduit, caused by unloading and decompression when a part of the SEC cone flank was removed (“sector collapse”), leading to the explosive opening of an eruptive fissure, which discharged a pyroclastic flow. An outstanding feature of this event is that it was not accompanied by any significant change in the seismic signal, which led us (Behncke et al. 2009) to exclude the opening of an eruptive fissure. However, Ferlito et al. point out that seismic evidence alone does not rule out their scenario, and cite the lack of seismic signals accompanying the start of the (rather voluminous, in terms of lava discharge, but purely effusive) 2004-2005 Etna eruption as support for their hypothesis. Finally, they describe what they interpret as the source fissure for the phreatomagmatic explosions and PDCs, and was the site of minor lava extrusion toward the end of the 16 November 2006 event. On their website, Ferlito et al. host a short (〈2 min) clip excerpted from a 40:54 min long video recorded by G. Tomarchio, cameraman of the Italian public television RAI, featuring only the 1425 GMT explosion and PDC. The integral, original version of that video (which was made available to INGV-CT immediately after the event) documents, amongst others, the presence of Behncke and INGV colleagues on-site, and shows a number of extremely similar explosions and PDCs over several hours prior to 1425 GMT, only on a smaller scale. As for the 1425 GMT event, the video spectacularly shows explosive activity, but nothing proving the opening of an eruptive fissure, neither does it show any landsliding as surmised by Norini et al. (2009). Our careful viewing of 1500 still photographs taken of the activity on that day, including nearly 1000 taken by INGV staff, plus other videos taken from different viewpoints (e.g., Movie S3 in the auxiliary material to our article) leads us to analogous conclusions. Videos and photographs document dozens of minor explosive, PDC-generating events before the major phreatomagmatic explosions and PDCs at 1425 GMT. The mechanisms of these events were virtually the same throughout, differing only in their magnitude. All were caused by hot, flowing lava mixing with wet, hydrothermally altered rocks making up the SEC cone’s flank that the lava was burrowing through. The “eruptive fracture” that Ferlito et al. refer to is a secondary feature, formed at the toe of a lava flow, which had flowed down the ESE side of the cone early on 16 November 2006 and was severed around noon by the progressive enlargement of the large scar eroded into the cone’s flank. Draining of the lava within the active channel of the severed flow led to accumulation of lava at the cone’s base, developing into a sort of bubble. For reasons unknown, this bubble drained during the late afternoon, yielding an extremely small flow. The pocket evacuated by this outflow subsided to become what Ferlito et al. interpret as an eruptive fissure, a single slightly elongate collapse depression, lying approximately 150 m northeast of the locus of the 1425 GMT phreatomagmatic explosions, which is well visible in aerial photographs taken after the events under discussion (Figure 1). The lava flow that Ferlito et al. claim to have sampled is the secondary flow formed by the draining of the pocket. It has no whatsoever genetic relationship with the phreatomagmatic explosions and PDCs of 1425 GMT. Another fundamental argument lies in the seismic record, and it is here that Ferlito et al. miss two major points. Firstly, unlike the seismic scenario usually observed at Etna in more than three decades of monitoring (e.g., Patanè et al., 2004), the start of the 2004-2005 lava effusion was exceptionally silent as many authors noted (e.g., Burton et al., 2005; Di Grazia et al., 2006; Corsaro et al., 2009). The onset of lava emission was indeed completely and unusually aseismic (in terms of volcano-tectonic seismicity, volcanic tremor changes, etc.), but it was also totally non-explosive, due to the nearly complete depletion in gas of the magma. Therefore, this effusive episode stands in marked contrast with the 16 November 2006 activity. It should be noted that when new, gas-rich magma moved toward the surface at a later stage of the 2004-2005 lava effusion, the volcanic tremor amplitude markedly increased (Di Grazia et al., 2006). Secondly, Ferlito et al. refer to papers (e.g., Cardaci et al., 1993; Patanè et al., 2004) which deal with the relationship between volcano-tectonic (VT) seismicity and the triggering of eruptive activity at Etna. VT seismicity covers just a part of the information contained in a seismic record (e.g., McNutt, 2000), a detail which can be easily missed by non-experts in seismology. There is indeed a variety of signals (e.g., long-period events, hybrid events, volcanic tremor, explosion quakes) related to the movement of fluids and/or magma, which can herald and accompany the opening of eruptive fractures. We did extensive cross-checking of the seismic record of the entire 2006 eruptive sequence, paying particular attention to episodes of new eruptive fissures opening. Each single event marked by the opening of new vents displaying some sort of explosive activity (this occurred during at least four of the paroxysms during the August-December 2006 eruptive sequence) shows conspicuous changes not only in the amplitude of the seismic (tremor) signal, but also in the location of the centroid of the tremor source, and frequency content, features amply discussed in our paper (Behncke et al., 2009). The migration of subsurface magma can thus be well documented, if it is accompanied by degassing. We would also like to point out that the phreatomagmatic explosions and PDCs of 1425 GMT occurred shortly after a conspicuous drop in the volcanic tremor amplitude (see Fig. 8 in Behncke et al., 2009). The lack of changes in the seismic signals concurrent with the PDC is also evident in the spectrograms (in which the frequency content excludes the occurrence of any seismic signals associated with fracturing, see Fig. 9 in Behncke et al., 2009) and in the records of all the broadband stations considered by Behncke et al. (2009), notwithstanding their vicinity to the site of the PDC-generating explosions (EBEL and ECPN are located ~1 km from the SEC, at 2899 and 3050 m elevation above sea level, respectively). Finally, the hypothesis of magma uprise at the base of the SEC cone caused by unloading related to the removal of a major portion of the cone’s flank, has been vested by Ferlito et al. (2007) in a volcanic sector collapse scenario similar to the catastrophic 1980 debris avalanche at Mount St. Helens. Volcanic sector collapse commonly takes place instantaneously, which is the contrary of what happened at the SEC on 16 November 2006. Thanks to our presence on site from the early morning onward, we were able to document how the removal of a portion of the flank of the cone occurred extremely slowly, over at least 5 hours (cf. Fig. 5 in Behncke et al., 2008). The material involved in this displacement moved at best at 50-80 m per hour, which is rather unlike the speed of volcanic debris avalanches. There was no such thing as a major landslide, and no such thing as a new eruptive fissure opening; what did happen was a very hazardous sequence of events, including phreatomagmatic explosions and quite low-temperature but fast-moving, dense pyroclastic density currents. Such volcanic phenomena deserve in-depth multidisciplinary studies, and the ongoing discussion underscores how much work is still necessary to better understand the dynamics of a versatile volcano such as Mount Etna.
    Description: Published
    Description: B12205
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: JCR Journal
    Description: open
    Keywords: Volcano monitoring ; Mt. Etna ; Volcanic hazard ; instruments and techniques ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 24
    Publication Date: 2017-04-04
    Description: This paper reports the use of diffusive tubes in determining HF, HCl, and SO2 in the volcanic plume of Mount Etna in an attempt to highlight the potential of this method in studying volcanoes. In a first application a network of 18 diffusive tubes was installed on Etna flanks, aimed at evaluating the atmospheric dispersion of the volcanic plume on a local scale. Results showed a monotonic decrease in volatile air concentrations with distance from the craters (HF from 0.15 to 〈0.003 mmol m3, HCl from 2 to 〈0.01 mmol m3, and SO2 from 11 to 0.04 mmol m3), revealing the prevalently volcanic contribution. Matching of SO2/HCl and HCl/HF volatile ratios with contemporaneous measurements at the summit craters validated the use of diffusive tubes in tracing the chemical features of a volcanic plume from remote locations. A first tentative assessment of dry deposition rates of volcanogenic acidic gases was also made, yielding 2.5 74 t d1 (SO2), 0.6 17 t d1 (HCl), and 0.02 0.6 t d1 (HF) and revealing the potential environmental impact of gas emissions. In a second experiment, carried out during the recent October 2002 to February 2003 eruption of Etna, diffusive tubes provided a continuous record of the chemical composition of the eruptive plume from a safe distance of 1 km from the vents, thus considerably decreasing the risks involved in sampling. This highlighted a clear time decrease in SO2 concentrations and SO2/HCl ratios, which was interpreted as due to progressive exhaustion of volatile degassing and eruption energy.
    Description: Published
    Description: D21308
    Description: partially_open
    Keywords: volcanic plumes ; impact of volcanic emissions ; sulfur and halogens chemistry ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 25
    Publication Date: 2017-04-04
    Description: In the last 13 years gas emissions from both the summit and the flanks of Mount Etna volcano have been monitored using remote sensing techniques (COSPEC, and FTIR since 2000) and on-site monitoring devices. The SO2 flux variations (600 to 25,000 Mg/day) indicated: (i) low values coinciding with deep seismicity prior to eruptions or/and preceding increases in summit volcanic activity; (ii) increasing trends tracking the ascent of fresh magma within the shallow feeding system and whose rate seems proportional to the speed of magma rise; (iii) decreasing trends related to progressive degassing of magma batches; (iv) an imbalance between the amount of magma erupted and that which contributed the SO2 emission (~ 13 % of the degassing magma having been erupted during the studied period), implying that magma degassing is dominantly intrusive; (v) a seasonal component, probably due to variations in solar zenith angle, meteorological parameters and, possibly, tidal forces.FTIR monitoring allowed to recognize significant variations of SO2/HCl and SO2/HF ratios in the volcanic plume which, combined with COSPEC data, provided new insight into the dynamics of ascent and degassing of discrete magma bodies. Strong variations in CO2-rich soil degassing are interpreted as markers of gradual magma ascent from great depth (〉10 km) to the upper (〈5 km) feeding system of Mt. Etna. These changes appear to precede increases in SO2 plume flux at the craters and, so, provide additional constraints upon the interpretation of COSPEC data and the modeling of magma rise at that volcano.
    Description: Published
    Description: 111-128
    Description: partially_open
    Keywords: Gas emissions ; Mt. Etna ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 26
    Publication Date: 2017-04-04
    Description: The Jalisco Block (JB) is a geologically and tectonically complex part of northwestern Mexico characterized by active subduction-type volcanism, rifting, and old stable structures. Thermal springs and groups of springs are widely distributed over JB. Bubbling gas from seven thermal springs located within different tectonic environments of the JB was analyzed for He, 20Ne, and N2 concentrations and d15N ratios. All gases are N2-dominant (〉84%) with the exception of one sample (Rio´ Purificacio´n), which has a significant CH4 content (about 50%). All collected gas samples are relatively high in He, up to 1500 ppm vol and with 3He/4He values ranging from 0.6 to 4.5 Ra. All measured nitrogen isotope ratios are heavier than air with d15N values ranging from 0.5 to 5.0%. The relative N2 excess with respect to air-saturated water computed on the basis of N2 and 20Ne contents indicates the contribution of a nonatmospheric N2 source. All the samples show a good correlation between d15N and the relative excess of N2 with d15N +5.3% for the maximum N2 excess of 100%. Due to a presumed lack of seafloor sediment involved in the subduction process, such a d15N positive value seems to reflect the addition to the fluids of a heavy nitrogen originating from metamorphism processes of rocks occurring within the overlying continental crust.
    Description: Published
    Description: 1-9
    Description: partially_open
    Keywords: bubbling gases ; forearc region ; Jalisco Block-Mexico ; nitrogen isotopes ; subduction-related volcanism ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data
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    Type: article
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  • 27
    Publication Date: 2017-04-04
    Description: The performance of a newly-developed portable gas analyzer, capable of real-time measurement of CO2, SO2 and H2S concentrations in volcanic gases, was tested at La Fossa Crater, Vulcano Island. The gas analyzer was used to acquire about 3000 determinations over the fumarolic field, allowing the definition of its chemical structure and heterogeneity. Our high-resolution analysis reveals that, in December 2004, the La Fossa fumarolic field was characterized by an oxidized inner core (SO2/H2S ratios of 3), and by more reducing conditions on its northern edge (SO2/H2S ratios of 1; range: 0.2–3.3). CO2/(SO2+H2S) molar ratios averaged 35 ± 21, with overlapping compositions for rim and inner crater fumaroles. S-poor compositions (CO2/(SO2+H2S) 50) characterized the field margins, probably due to deposition of native sulfur. Based on the above data and an SO2 flux of 18 ± 3 t.d-1, we estimate CO2 and H2S output rates from the volcano of 420 ± 250 and 4 ± 2 t.d-1, respectively.
    Description: Published
    Description: L13309
    Description: partially_open
    Keywords: electrochemical sensors ; fumarolic gases ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 28
    Publication Date: 2017-04-04
    Description: No abstract
    Description: Published
    Description: 117-118
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: open
    Keywords: geomorphology ; tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
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  • 29
    Publication Date: 2017-04-04
    Description: In the text
    Description: Published
    Description: 219-224
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: open
    Keywords: coda Q ; Phlegraean Fielsa ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 30
    Publication Date: 2017-04-04
    Description: Repeated phenomena of flank instability accompanied the 28 December 2002 to 21 July 2003 eruption of Stromboli volcano. The major episodes were two tsunamigenic landslides on 30 December 2002, 2 d after the volcano unrest. After 30 December, sliding processes remodeled the area affected by slope instability.We propose analyses of 565 sliding episodes taking place from December 2002 to February 2003.We try to shed light on their main seismic features and links with the ongoing seismic and volcanic activity using variogram analysis as well. A characterization of the seismic signals in the time and frequency domains is presented for 185 sliding episodes. Their frequency content is between 1 Hz and 7 Hz. On the basis of the dominant peaks and shape of the spectrum, we identify three subclasses of signals, one of which has significant energy below 2 Hz. Low-frequency signatures were also found in the seismic records of the landslides of 30 December, which affected the aerial and submarine northwestern flank of the volcano. Accordingly, we surmise that spectral analysis might provide evidence of sliding phenomena with submarine runouts.We find no evidence of sliding processes induced by earthquakes. Additionally, a negative statistical correlation between sliding episodes and explosion quakes is highlighted by variogram analysis. Variograms indicate a persistent behavior, memory, of the flank instability from 5 to 10 d.We interpret the climax in the occurrence rate of the sliding processes between 24 and 29 January 2003 as the result of favorable conditions to slope instability due to the emplacement of NW-SE aligned, dike-fed vents located near the scarp of the landslide area. Afterward, the stabilizing effect of the lava flows over the northwestern flank of the volcano limited erosive phenomena to the unstable, loose slope not covered by lava.
    Description: This work was supported financially by Istituto Nazionale di Geofisica e Vulcanologia and Dipartimento per la Protezione Civile, project INGV-DPC V4/02.
    Description: Published
    Description: Q04022
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: rockfalls ; seismicity ; volcanoes ; volcano collapses ; Stromboli ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 31
    Publication Date: 2017-04-04
    Description: We applied the Multi-GAS technique to measure compositions of the volcanic plumes continuously discharged from summit craters of Voragine, Northeast and Bocca Nuova at Mount Etna, in an attempt to estimate compositions of the source volcanic gases. The estimated CO2/SO2 and H2O/CO2 ratios of the volcanic gases show a large variation ranging from 0.6 to 30 and from 1 to 18, respectively. This variability overlaps with the compositional range of dissolved volatiles in melt inclusions and their coexisting bubbles in a magma chamber and can be caused by the low-pressure degassing of a magma with variable bubble content ranging from 0.3 to 15 wt.%. The variable bubble content in the magma is likely a result of supply of deep-derived CO2-rich gas phase to the chamber and subsequent bubble-magma differentiation by bubble ascent in the magma chamber. In contrast, the variation of volcanic gas composition can also be caused by changes of degassing pressure (gas–magma separation pressure), ranging from 0 to 100 MPa, as a result of changes in the depth of the top of the convecting magma in volcanic conduits. Both mechanisms can cause similar compositional variations. However, the two mechanisms will result in contrasting correlations between the SO2 emission rates and the gas compositions that can be examined by parallel observations of the emission rates and compositions in the future.
    Description: Published
    Description: B09203
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: Plume ; gas ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 32
    Publication Date: 2017-04-04
    Description: We report the first measurements of volcanic gases with an unmanned aerial vehicle (UAV). The data were collected at La Fossa crater, Vulcano, Italy, during April 2007, with a helicopter UAV of 3 kg payload, carrying an ultraviolet spectrometer for remotely sensing the SO2 flux (8.5 Mg d 1), and an infrared spectrometer, and electrochemical sensor assembly for measuring the plume CO2/SO2 ratio; by multiplying these data we compute a CO2 flux of 170 Mg d 1. Given the deeper exsolution of carbon dioxide from magma, and its lower solubility in hydro-thermal systems, relative to SO2, the ability to remotely measure CO2 fluxes is significant, with promise to provide more profound geochemical insights, and earlier eruption forecasts, than possible with SO2 fluxes alone: the most ubiquitous current source of remotely sensed volcanic gas data.
    Description: Published
    Description: L06303
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Plume measurements ; carbon dioxide fluxes ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 33
    Publication Date: 2017-04-04
    Description: This study presents baseline data for future geochemical monitoring of the active Tacaná volcano–hydrothermal system (Mexico–Guatemala). Seven groups of thermal springs, related to a NW/SE-oriented fault scarp cutting the summit area (4,100m a.s.l.), discharge at the northwest foot of the volcano (1,500–2,000m a.s.l.); another one on the southern ends of Tacaná (La Calera). The near-neutral (pH from 5.8 to 6.9) thermal (T from 25.7°C to 63.0°C) HCO3–SO4 waters are thought to have formed by the absorption of a H2S/SO2–CO2-enriched steam into a Cl-rich geothermal aquifer, afterwards mixed by Na/HCO3-enriched meteoric waters originating from the higher elevations of the volcano as stated by the isotopic composition (δD and δ18O) of meteoric and spring waters. Boiling temperature fumaroles (89°C at~3,600m a.s.l. NW of the summit), formed after the May 1986 phreatic explosion, emit isotopically light vapour (δD and δ18O as low as −128 and −19.9‰, respectively) resulting from steam separation from the summit aquifer. Fumarolic as well as bubbling gases at five springs are CO2-dominated. The δ13CCO2 for all gases show typical magmatic values of −3.6 ± 1.3‰ vs V-PDB. The large range in 3He/4He ratios for bubbling, dissolved and fumarolic gases [from 1.3 to 6.9 atmospheric 3He/4He ratio (RA)] is ascribed to a different degree of near-surface boiling processes inside a heterogeneous aquifer at the contact between the volcanic edifice and the crystalline basement (4He source). Tacaná volcano offers a unique opportunity to give insight into shallow hydrothermal and deep magmatic processes affecting the CO2/3He ratio of gases: bubbling springs with lower gas/water ratios show higher 3He/4He ratios and consequently lower CO2/3He ratios (e.g. Zarco spring). Typical Central American CO2/3He and 3He/4He ratios are found for the fumarolic Agua Caliente and Zarco gases (3.1 ± 1.6 × 1010 and 6.0 ± 0.9 RA, respectively). The L/S (5.9 ± 0.5)and (L + S)/M ratios (9.2 ± 0.7) for the same gases are almost identical to the ones calculated for gases in El Salvador, suggesting an enhanced slab contribution as far as the northern extreme of the Central American Volcanic Arc,Tacana
    Description: In press
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 2.4. TTC - Laboratori di geochimica dei fluidi
    Description: JCR Journal
    Description: reserved
    Keywords: Tacaná volcano ; Fluid geochemistry ; Volcano–hydrothermal system ; Bubbling gases ; Fumaroles ; Isotopes ; Volcanic surveillance ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data
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  • 34
    Publication Date: 2017-04-04
    Description: Kostrov's (1974) algorithm for seismic-strain tensor computations, in the version implemented by Wyss et al. (1992a) for error estimates, has been applied to shear-type earthquakes occurring beneath the Etna volcano during 1990-1996. Space-time variations of strain orientations and amplitudes have been examined jointly with ground-deformation and gravimetric data collected in the same period and reported in the literature. Taking also into account the information available from volcanological observations and structural geology, we propose a model assuming that hydraulic pressure by magma emplaced in nearly north-south vertical structures produces the E-W orientation of the maximum compressive strain found in the upper 10 km beneath the crater area. In contrast, regional tectonics deriving from the slow, north-south convergence between the African and European plates appear to play a dominant role in the generation of stress and strain fields at crustal depths deeper than 10 km below the volcano. According to our interpretation, the progressive ascent of magma through the upper crust prior to eruption produces the observed gravity changes, cone inflation and unusual seismic strain rate in the upper 10 km associated with a more sharply defined seismic deformation regime (i.e. very small confidence limits of the epsilon 1 orientation). In agreement with this model, deflation revealed by ground-deformation data during the course of the major 1991-1993 eruption was accompanied by a practically nil level of shallow seismicity.
    Description: Published
    Description: 318-330
    Description: JCR Journal
    Description: open
    Keywords: Mt. Etna ; Italy ; Earthquakes ; Seismic strain ; Stress inversion ; Volcanic processes ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 35
    Publication Date: 2017-04-04
    Description: Volcanic and geothermal areas are one of the major natural sources of H2S to the atmosphere. Its environmental impact is often the main cause of the opposition to the development of geothermal energy exploitation programs. In this paper we analyze the air concentrations and dispersion pattern of naturally emitted H2S at the geothermal area of Sousaki (Corinthia, Greece). Measurements, made with a network of passive samplers, evidence a rapid decrease of concentration values away from the emission points. The fact that the decrease is more pronounced in the summer with respect to the winter indicates that it is not only due to a dilution effect, but also to redox reactions favoured by higher temperatures and intense sunlight typical of the summer period.
    Description: Published
    Description: 1723-1728
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Hydrogen sulphide ; Environmental impact of volcanic activity ; Gas hazard ; Passive samplers ; 01. Atmosphere::01.01. Atmosphere::01.01.03. Pollution ; 01. Atmosphere::01.01. Atmosphere::01.01.07. Volcanic effects ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
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  • 36
    Publication Date: 2017-04-04
    Description: The period September–November 2007 was characterized at Mount Etna by explosive activity and intense degassing. During this time interval, infrasonic signals were recorded by an infrasonic network. By a triggering procedure, about 1000 infrasonic events were found, characterized by very high signal-to-noise ratio and grouped into nine families. Successively, the spectral analysis allowed subdividing these nine families into three clusters based on the peak frequency and the quality factor of the events. Finally, by the location analysis a cluster (cluster 1) was related to the degassing activity of the northeast crater (NEC), while the other two (clusters 2 and 3) to the explosive activity of the southeast crater (SEC). The comparison between the stacked infrasonic waveforms, interpreted as generated by the vibration of large gas bubbles, and the synthetic ones, permitted to calculate radius, length of the bubble, and initial overpressure, by a genetic algorithm method. The higher overpressure values of cluster 3 compared to the cluster 2 values were in good agreement with the stronger intensity of the explosions accompanying the infrasonic events of cluster 3. The variation of both intensities and waveforms is tentatively attributed to the occasional accumulation of lithic clasts (due to moderate landslides?) on the explosive vent. Indeed, events belonging to cluster 3 were no longer observed once the landslides had ended. Finally, the daily emitted gas volume, related to the active degassing, was estimated for NEC and SEC by using the infrasonic data during the studied period.
    Description: Published
    Description: B08308
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Mt. Etna ; Infrasound ; volcano monitoring ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 37
    Publication Date: 2017-04-04
    Description: A major explosion occurred at Stromboli on April 5 2003, being the most powerful event over a period of exceptional eruptive activity lasting from December to July. Here, we describe results from a network of diffusive tubes set up on the Stromboli’s summit area, aimed at a characterisation of plume composition (SO2, HCl, HF) prior to and after April 5. Data analysis revealed anomalous sulphur degassing 2–3 days before the event, when SO2/HCl ratios (9) significantly higher than those typical of quiescent degassing (1) were recorded. We interpret this exceptional plume signature as an evidence of S-rich magmas ascending in the shallow plumbing system, and propose high SO2/HCl as a potential precursor of major explosions on the volcano. The post-April 5 phase was characterised by time-decreasing SO2/HCl and SO2/HF plume ratios, ascribed to declining magma feeding as a prelude to restoration of ‘‘normal’’ Strombolian activity.
    Description: Published
    Description: L14607
    Description: partially_open
    Keywords: magmatic degassing ; paroxysm ; Stromboli ; 04. Solid Earth::04.03. Geodesy::04.03.06. Measurements and monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 38
    Publication Date: 2017-04-04
    Description: On 2nd/3rd November 2002, a huge amount of gas, mainly composed of CO2, was suddenly released from the sea bottom off the coast of Panarea, producing a ‘‘crater’’20 by 10 meters wide and 7 meters deep. The gas output was estimated to be 109 l/d, two orders of magnitude higher than that measured in the 1980s. The anomalous degassing rate lasted for some weeks, slowly decreasing to an almost constant rate of about 4 x 107 l/d after two months. The geothermo- barometric estimations revealed an increase of both the temperature and pressure in the geothermal system feeding the sampled vents. The 3He/4He ratios were similar to those measured in nearby Stromboli. We have monitored the area for the last two decades, and based on our intensive and extensive geochemical measurements, have ascertained that the geothermal reservoir has lost its steady state. We maintain that a new magmatic input caused these phenomena.
    Description: - Istituto Nazionale di Geofisica e Vulcanologia, Osservatorio Vesuviano, Naples, Italy. - Istituto Nazionale di Geofisica e Vulcanologia, Sezione di Palermo, Palermo, Italy. - Dipartimento Chimica e Fisica della Terra ed Applicazioni, Palermo, Italy.
    Description: Published
    Description: L07619
    Description: partially_open
    Keywords: Submarine degassing ; magmatic fluids ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
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  • 39
    Publication Date: 2017-04-04
    Description: Five gas discharges in the area of Mount Etna volcano (Italy) and in the near Hyblean plateau have been monitored since 1996. All the emissions displayed low contributions from crustal fluids, whereas magmatic gases were the main component. Selective dissolution of these gases into hydrothermal aquifers has been recognized and modeled, allowing us to calculate the original composition of the magma-released gases. The inferred composition of the magmatic gases exhibits synchronous variations of He/Ne and He/CO2 ratios, which are coherent with the magma degassing process. On the basis of numerical simulations of volatile degassing from Etnean basalts we have computed the initial and final pressures of the magma batches feeding the emissions. We thus can define the levels of the Etna plumbing system where magmas are stored. Pressure values were around 360 and 160 MPa for initial and final stages, respectively, meaning related depths of about 10 and 3 km below sea level, matching those obtained by geophysical investigations for the deep and shallow magma reservoirs. In addition, we have been able to recognize episodes of magma migration from the deeper reservoir toward the shallow one. An important magma injection into the shallow storage volume was detected during the onset of the 2001 eruption (17 July). No further injection had taken place during this period until September 2001, providing a possible reason for the quick exhaustion of the eruption. In view of this we suggest that the sampled emissions are a powerful geochemical tool to investigate the Etna’s plumbing system and its magma dynamics, as well as the development of eruptive events.
    Description: Published
    Description: 2463
    Description: partially_open
    Keywords: gas geochemistry ; magma degassing ; modeling ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 40
    Publication Date: 2017-04-04
    Description: Five years of gas monitoring from selected sites suggest that Mt Etna’s plumbing system is much more extensive than previously reported. It extends at least 40 km SW from the volcano’s boundary along the NE-SW regional fault, where it discharges about 200 tons/day of gas, containing helium with mantle-type isotopic composition. Synchronous variations of 3He/4He isotopic ratios in gas sampled at sites located 60 kilometers apart have allowed us to detect pulses of ascending magma in the plumbing system, thus providing a powerful tool for eruption forecasting. Following summer 2001 eruption, the still increasing trend of the 3He/4He ratios indicates that magma storage is even now occurring at a shallow depth. Hence, the volcano maintains a high capacity to re-erupt within the next few months.
    Description: Published
    Description: 1057
    Description: partially_open
    Keywords: helium isotopes ; geochemical monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 41
    Publication Date: 2017-04-04
    Description: During 1991−93 at Mount Etna, long-period (LP) events occurring in swarms characterized the evolution of the eruption. The presence of multiplets i.e. groups of events with similar waveform signatures, has been recognized within this activity. Traditional techniques for locating LP events do not allow obtaining reliable hypocenters, which have only succeeded in placing earthquakes in a roughly 1 km2 area slightly east of the Mt. Etna Northeast Crater. Hypocenters have been relocated in two steps: the absolute location has been improved using Thurber’s code and a complex 3D velocity model; a highly precise relative location has been applied on multiplets to define the source geometry. 3D locations and high precision analysis suggest that during the 1991−93 eruption the resonator producing LP events was a part of the uppermost Northeast Crater conduit, measuring 210 meters in height and 45−50 meters in diameter.
    Description: Published
    Description: 663-674
    Description: reserved
    Keywords: waveform correlation ; stacked events ; 1991−93 eruption ; conduct geometry ; Mt. Etna Northeast Crater ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
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  • 42
    Publication Date: 2017-04-04
    Description: Fluorine is one of the many environmental harmful elements released by volcanic activity. The content of total, oxalate extractable and water extractable fluorine was determined in 96 topsoils of three active volcanic systems of southern Italy (Mt. Etna, Stromboli and Vulcano). Total fluorine content (FTOT) ranges from 112 to 7430 mg kg-1, F extracted with oxalate (FOX) ranges from 16 to 2320 mg kg-1 (2 – 93 % of FTOT) and F extracted with distilled water (FH2O) ranges from 1.7 to 159 mg kg-1 (0.2 – 40 % of FTOT). Fluorine in the sampled topsoils derives both from the weathering of volcanic rocks and ashes and from enhanced deposition due to volcanic gas emissions either from open-conduit passive degassing (Mt. Etna and Stromboli) or from a fumarolic field (Vulcano). Fluorine accumulation in the studied soils does generally not present particular environmental issues except for a few anomalous sites at Vulcano where measured contents could be dangerous both for vegetation and for grazing animals.
    Description: Published
    Description: 413-423
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: soil fluorine ; oxalate extractable F ; water extractable F ; environmental impact of volcanic F ; Sicily ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
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  • 43
    Publication Date: 2017-04-04
    Description: The 2002–2003 Etna eruption is studied through earthquake distributions and surface fracturing. In September 2002, earthquake-induced surface rupture (sinistral offset 0.48 m) occurred along the E-W striking Pernicana Fault (PF), on the NE flank. In late October, a flank eruption accompanied further ( 0.77 m) surface rupturing, reaching a total sinistral offset of 1.25 m; the deformation then propagated for 18 km eastwards to the coastline (sinistral offset 0.03 m) and southwards, along the NW-SE striking Timpe (dextral offset 0.04 m) and, later, Trecastagni faults (dextral offset 0.035 m). Seismicity (〈4 km bsl) on the E flank accompanied surface fracturing: fault plane solutions indicate an overall ESEWNWextension direction, consistent with ESE slip of the E flank also revealed by ground fractures. A three-stage model of flank slip is proposed: inception (September earthquake), climax (accelerated slip and eruption) and propagation (E and S migration of the deformation).
    Description: Published
    Description: 2286
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 3.2. Tettonica attiva
    Description: 3.5. Geologia e storia dei sistemi vulcanici
    Description: 3.6. Fisica del vulcanismo
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: volcano seismology ; surface fracturing ; flank slip ; eruption ; Etna ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.01. Earth Interior::04.01.02. Geological and geophysical evidences of deep processes ; 04. Solid Earth::04.02. Exploration geophysics::04.02.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.99. General or miscellaneous ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 04. Solid Earth::04.07. Tectonophysics::04.07.99. General or miscellaneous ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.05. Stress ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.02. Data dissemination::05.02.03. Volcanic eruptions
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  • 44
    Publication Date: 2017-04-04
    Description: Two-dimensional cross sections of the sulphur dioxide (SO2) distribution in the volcanic gas plume of Mt. Etna were reconstructed using tomographic techniques. The data for these projections were generated by a network of five automated scanning spectrometers, positioned on the flanks of the volcano. These measure slant-column amounts of SO2 at 105 different angles, every four minutes. Stable wind conditions allow the plume to be monitored on 82% of days. A time-series of plume cross sections was computed, revealing the potential of this method to track variations in plume position and structure on timescales of minutes to hours, a result of potential importance for air traffic and civil defence in case of eruption, when copious amounts of fine ash can be transported.
    Description: Published
    Description: L17811
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: tomography ; SO2 ; DOAS ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 45
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    American Geophysical Union
    In:  An edited version of this paper was published by AGU. Copyright (2009) American Geophysical Union
    Publication Date: 2017-04-04
    Description: Three eruptive episodes during the 2006 summit eruptions of Mount Etna were exceptionally well documented by visual, seismic and thermal monitoring. The first (16 November) was strongly explosive, with vigorous Strombolian activity and ash emission from multiple vents, lava emission, and phreatomagmatic explosions generating pyroclastic density currents (PDCs). The second episode (19 November) had a rather weakly explosive component, with mild Strombolian activity but more voluminous lava emission. The third (24 November) was a moderately explosive paroxysm, with intermittent lava fountaining and generation of a tephra column as well as lava emission and PDCs. Data recorded by a thermal monitoring camera clearly document the different phases of each paroxysm, weather clouds occasionally hampering thermal monitoring. The images show a rapid onset of the volcanic activity, which during each of the paroxysms reached a peak in eruptive and thermal intensity, and then decreased gradually. The stronger phreatomagmatic explosions and PDCs on 16 and 24 November did not yield any seismic signature linked to the opening of new vents, nor were they associated with peculiar characteristics of the seismic signal. Nevertheless, eruptive styles (Strombolian activity, lava emission) and different levels in the intensity of explosive activity were generally well reflected in the amplitude and frequency content of the seismic signal, and in the source location of the volcanic tremor centroid throughout the three eruptive episodes. This multidisciplinary study, therefore, not only provides a key to distinguish between endogenous and exogenous origins of the phenomena observed, but also documents the complex magma dynamics within the volcano.
    Description: Published
    Description: B03211
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: JCR Journal
    Description: reserved
    Keywords: Volcano monitoring ; Mt Etna ; volcanic hazard ; instruments and techniques ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 46
    Publication Date: 2020-02-24
    Description: Measurements of 220Rn and 222Rn activity and of CO2 flux in soil and fumaroles were carried out on Mount Etna volcano in 2005–2006, both in its summit area and along active faults on its flanks. We observe an empirical relationship between (220Rn/222Rn) and CO2 efflux. The higher the flux of CO2, the lower the ratio between 220Rn and 222Rn. Deep sources of gas are characterized by high 222Rn activity and high CO2 efflux, whereas shallow sources are indicated by high 220Rn activity and relatively low CO2 efflux. Excess 220Rn highlights sites of ongoing shallow rock fracturing that could be affected by collapse, as in the case of the rim of an active vent. Depletion both in 220Rn and in CO2 seems to be representative of residual degassing along recently active eruptive vents.
    Description: This work was funded by the Istituto Nazionale di Geofisica e Vulcanologia (S.G., M.N.) and by the Dipartimento per la Protezione Civile (Italy), projects V3_6/28-Etna (M.N.) and V5/08-Diffuse degassing in Italy (S.G.), and NSF EAR 063824101 (K.W.W.S.).
    Description: Published
    Description: Q10001
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: radon ; thoron ; carbon dioxide ; rock stress ; gas transport ; Mount Etna ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 05. General::05.02. Data dissemination::05.02.01. Geochemical data
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 47
    Publication Date: 2020-05-29
    Description: In January 2002 Mount Nyiragongo erupted foiditic lavas that covered the Southern volcano flank devastating vast urban areas. Lava flows originated from vents at different heights on the eruptive fissure displayed different velocities, from tens of km/h at the highest vents to slow-advance (0.1–1 km/h) in Goma town several km away from the volcano. To understand the different behavior of lava flows and their threat to the local population, we undertook a multidisciplinary study involving textural and rheological measurements and numerical simulations of heat transfer during magma ascent. We demonstrate that pre-eruptive cooling and syn-eruptive undercooling of magma determined the different rheological behavior of lava flows erupted from vents at diverse heights. Venting at lower altitudes is expected to produce viscous, slowly advancing lavas, although development of fluid, faster flows should be included among possible future eruptive scenarios.
    Description: Published
    Description: L06301
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: Nyiragongo volcano ; textural and rheological measurements ; numerical simulations ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 48
    Publication Date: 2022-02-16
    Description: The role of mud volcanoes (MVs) as a source of methane(CH4) flux to the atmosphere and the ocean has been increasingly recognised in the last several years (Milkov 2000; Dimitrov 2002, 2003; Etiope and Klusman 2002; Kopf 2002, 2003; Milkov et al. 2003; Etiope and Milkov 2004). In one of the most recent papers, Kopf (2003) claims to report a reliable estimate of the global CH4 emission from MVs. However, the significance and usefulness of the estimate presented by Kopf (2003) are rather poor. The used dataset is smaller than in previous studies (although the author makes a reverse claim), and some previously published works are misquoted and misinterpreted. Numerous arithmetic mistakes made during simple calculations and data manipulations lead to confusing results and conclusions. In this comment, we highlight some of the most significant problems with the estimates published by Kopf (2003).
    Description: Published
    Description: 490-492
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: Methane ; mud volcanoes ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
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  • 49
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    European journal of nutrition 24 (1985), S. 113-119 
    ISSN: 1436-6215
    Keywords: Chloramphenicol ; pharmacokinetics ; residue ; pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Residues of Chloramphenicol (CAP) were examined in 24 pigs after intramuscular injection of 30 mg CAP/kg body weight. Two pigs were slaughtered after 3, 6, 12,18, 24, 36 hours, 2, 3, 6, 10, 21 and 30 days, respectively. CAP-concentrations were determined in muscle, blood, urine, liver, kidney, bile, and fat. Methods used were gas-liquid chromatography and radioimmunoassay. Detection limits reached were 1−5 ppb. The concentration-time curves obtained reflected a long elimination phase and allowed only calculation of this half-life. Elimination half-life was estimated to be for muscle, blood and urine 160–170 hours, for kidney 310 and for bile 250 hours. Significant correlations were found to exist between CAP-concentrations in plasma and muscle. It appears that blood would be a good body fluid for monitoring CAP-residues in tissue.
    Notes: Zusammenfassung Zur Untersuchung des Rückstandsverhaltens von Chloramphenicol (CAP) wurden 24 Mastschweine, 24–28 Wochen alt, intramuskulär mit 30 mg CAP/kg Körpergewicht behandelt und je 2 Tiere nach 3, 6, 12, 18, 24, 36 Stunden, 2, 3, 6, 10, 21 und 30 Tagen geschlachtet. Die CAP-Gehalte in Muskulatur, Blut, Urin, Leber, Niere, Galle und Fett wurden gaschromatographisch und radioimmunologisch bestimmt. Die Nachweisgrenze beider Methoden liegt in Abhängigkeit von der Matrix zwischen 1 und 5 ppb. Die erhaltenen Kinetiken weisen eine terminale Elimination auf, deren Halbwertszeiten für Muskulatur, Blut und Urin ca. 160–170 Stunden, für Niere 310 Stunden und für Galle 250 Stunden betragen. Die CAP-Konzentration in Muskulatur und Blut weisen eine signifikante, lineare Korrelation auf. Blutuntersuchungen könnten deshalb als Screening-Methode bei umfangreichen Rückstandskontrollen eingesetzt werden.
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  • 50
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    European journal of nutrition 22 (1983), S. 14-26 
    ISSN: 1436-6215
    Keywords: branched chain α-keto acids ; 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate ; 3-methyl-2-oxobutyrate ; dehydrogenation ; transamination ; pharmacokinetics ; absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Michaelis-Konstanten und Aktivitäten von Dehydrogenasen und Transaminasen der drei verzweigten α-Ketosäuren Keto-Valin, Keto-Leucin und Keto-Isoleucin in Leber, Niere, Skeletmuskel und Gehirn von Ratten werden mitgeteilt. Nach oraler Zufuhr passieren nur 11–22% der Ketosäuren unverändert die Leber. Aus pharmakokinetischen und Resorptions-Untersuchungen erhaltene Blutspiegel an Ketosäuren werden zu den Michaelis-Konstanten in Beziehung gesetzt. Bei den geringen Konzentrationen an Ketosäuren nach oraler Zufuhr kann angenommen werden, daß die oxidativen Prozesse in den nichthepatischen Geweben über die Transaminierung überwiegen. Daten über die Wachstumseffizienz von verzweigtkettigen α-Ketosäuren im Vergleich zu den entsprechenden Aminosäuren stimmen mit dieser Vorstellung überein. Bei intravenöser Verabreichung müßten die Voraussetzungen für Transaminierung besser sein als nach oraler Zufuhr. Auf der Basis von Daten aus der Literatur werden die Übertragbarkeit unserer Befunde auf den Menschen und die verschiedenen Faktoren, welche die Effizienz der verzweigten α-Ketosäuren durch Einwirkung auf ihren Stoffwechsel beeinflussen können, diskutiert.
    Notes: Summary Miehaelis-constants and enzyme activities for dehydrogenation and transamination of the three branched chainα-keto acids in liver, kidney, skeletal muscle, and brain of rats are reported. After oral load only 11–22 % of the keto acids pass the liver unchanged. Blood levels in pharmacokinetic and absorption studies are related to the Michaelis-constants. At the low keto-acid concentrations after oral application, dehydrogenation in the non-hepatic tissues is supposed to prevail over transamination. Data on feed efficiency of branched chain α-keto acids reported in the literature support this view. The chance for transamination is better after intravenous administration. The transferability of our data to humans, and various factors influencing the efficiency of branched chain α-keto acids are discussed in connection with data reported in the literature.
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  • 51
    ISSN: 1420-9071
    Keywords: Interferon ; immunomodulator ; catabolism ; pharmacokinetics ; administration routes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary When human recombinant interferon-α2 diluted in saline was injected s.c. into rabbits, the total amount recovered in thoracic lymph was less than 0.4%. Recoveries increased from 2- to 8-fold if interferon was injected in 4% albumin or with hyaluronidase, respectively. Albumin added to interferon acts as an interstitial fluid expander, thus favoring interferon absorption through lymphatics rather than blood capillaries. This strategy may increase the therapeutic index of interferon.
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  • 52
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    European journal of clinical pharmacology 32 (1987), S. 631-634 
    ISSN: 1432-1041
    Keywords: salbutamol ; albuterol ; pharmacokinetics ; bioavailability ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Salbutamol was administered to sixteen healthy male volunteers intravenously and by mouth in liquid, tablet, and capsule form using a Latin-Squares design. Pharmacokinetic parameters from intravenous data were similar to previously reported values obtained with oral administration, with a mean terminal half-life of 3.8 h and a mean clearance of 439 ml·min−1·1.73 m−2. Peak plasma concentrations of 10–20 ng·ml−1 were obtained 1–3 h following oral administration. The absolute bioavailability of each of the oral preparations was 44%. While statistically significant differences in lag time and time to peak concentration were noted among the various oral preparations, the drug is rapidly absorbed in all three dosage forms and the observed differences are unlikely to be of clinical significance.
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  • 53
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    European journal of clinical pharmacology 42 (1992), S. 101-105 
    ISSN: 1432-1041
    Keywords: Rufloxacin ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma and urine kinetics of rufloxacin were assessed in healthy volunteers after single (100, 200, 400 and 800 mg) and multiple (300 mg followed by 150 mg daily, Group 1, and 400 mg followed by 200 mg daily, Group 2) oral doses. The kinetics of a single oral dose of 800 mg was assessed in fasting and non-fasting subjects to assess the influence of food intake on drug absorption. The AUCs were 134, 266 and 375 μg · h · ml−1 after 100, 200 and 400 mg, respectively. The AUC after 800 mg p. o. was 715 μg · h · ml −1 in fasting subjects and 614 μg · h · ml−1 in non-fasting subjects. The parameters of the model and the mean renal clearance values indicated some departure from linearity in rufloxacin kinetics. After multiple doses the plasma drug levels during the 6th treatment day were similar to those after the first dose in Group 1 and were about 30–40% higher after the first dose in Group 2. The half-lives after the last dose were much shorter than those estimated in the single dose studies (33–36 h and 50–80 h, respectively).
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  • 54
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    European journal of clinical pharmacology 42 (1992), S. 535-538 
    ISSN: 1432-1041
    Keywords: Meropenem ; Carbapenem ; pharmacokinetics ; uraemia ; haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 24 or 48 h. Meropenem concentrations in plasma and urine were measured by a microbiological assay. The mean peak plasma concentration of meropenem ranged from 28 to 40 μg·ml−1 and was not affected by the degree of renal impairment. The terminal half-life of meropenem was approximately 1 h in subjects with normal kidney function and it was proportionately increased as renal function decreased. A significant linear relationship between total body clearance and creatinine clearance as well as between renal clearance and creatinine clearance was observed. The mean apparent volume of distribution at steady state was not significantly altered in uraemic patients. The mean cumulative urinary recovery of meropenem in healthy volunteers was 77% of the administered dose and it was significantly decreased in patients with renal impairment. Haemodialysis shortened the elimination half-life, from 9.7 h during the predialysis period to 1.4 h during the dialysis period. The dose of meropenem should be reduced in relation to the decrease in creatinine clearance.
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  • 55
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    European journal of clinical pharmacology 34 (1988), S. 179-186 
    ISSN: 1432-1041
    Keywords: ceftazidime ; pharmacokinetics ; elderly patients ; young volunteers ; acute infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of ceftazidime have been investigated after single and multiple i.v. doses in 9 young healthy male volunteers and 15 elderly male patients with acute bacterial infections. All subjects had normal, age-correlated glomerular function. Distribution and elimination in young volunteers were unaffected by posture and were similar to what has been reported earlier. In contrast, elderly patients had longer t1/2β (3.1 vs 1.9 h), larger AUC (414.0 vs 276.6 h·mg/l), lower total and renal clearances, reduced urinary recovery over 12 h and enlarged Vss. Total serum clearance of ceftazidime was closely correlated with the51Cr-EDTA clearance. There was no significant change in51Cr-EDTA clearance after seven days of treatment. A reduction in the dose of betalactam antibiotics eliminated by the kidney is advisable in elderly patients with an acute bacterial infection.
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  • 56
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    European journal of clinical pharmacology 42 (1992), S. 559-560 
    ISSN: 1432-1041
    Keywords: Mefloquine ; Thai subjects ; pharmacokinetics ; Primaquine ; drug interaction ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
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  • 57
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    European journal of clinical pharmacology 39 (1990), S. 395-397 
    ISSN: 1432-1041
    Keywords: atropine ; exercise ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven healthy males (19–32 y) underwent each of four separate conditions in a repeated measures design. Five of these subjects underwent an additional trial. In four of five trials subjects received 2.0 mg atropine sulfate intramuscularly in the anterolateral portion of the left thigh: at rest (T1); following completion of a single exercise (Ex) bout (T2), (Each bout consisted of 25 min of stationary cycling at 40% VO2 max with 5 min of seated rest), prior to three Ex bouts (T3) and following one and prior to three Ex bouts (T5). Trial 4 (T4) was the same as T3 with the substitution of a saline placebo. Serum samples were collected over a 12 h period and atropine concentration was determined by RIA. Ex trials were compared to T1. Ex prior to atropine (T2) significantly decreased the mean volume of distribution (Vz, 278 vs 2321). Ex in T3 significantly decreased the serum half life (t1/2, 4.2 vs 3.5 h), Vz (278 vs 1981), and clearance (CL, 763 vs 638 ml·min−1) and significantly increased the peak concentration (Cp, 6.7 vs 12.3 ng·ml−1) and area under the curve (AUC, 44.1 vs 53.1 ng·ml−1). In T5, Ex significantly decreased the t1/2 (3.4 h), Vz (182 l) and CL (575 ml·min−1) and significantly increased the absorption rate constant (ka, 0.482 vs 1.1 min−1), elimination rate constant (ke, 0.0012 vs 0.0015 min−1), Cp (14 ng·ml−1) and AUC (53.3 ng·h·ml−1). These results demonstrate that moderate Ex either prior to and/or immediately following drug administration has the capacity to significantly modify atropine pharmacokinetics.
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  • 58
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    European journal of clinical pharmacology 42 (1992), S. 689-691 
    ISSN: 1432-1041
    Keywords: Diphemanil methylsulphate ; pharmacokinetics ; healthy subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax=2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
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  • 59
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    European journal of clinical pharmacology 42 (1992), S. 693-694 
    ISSN: 1432-1041
    Keywords: Loperamide ; loperamide oxide ; diarrhoea ; pharmacokinetics ; dose-proportionality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
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  • 60
    ISSN: 1432-1041
    Keywords: Alpidem ; Anxiolytics ; pharmacokinetics ; tolerance ; metabolites ; sedation ; adverse events
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind, placebo-controlled, crossover experiment in 21 healthy male volunteers, aged 19 to 27 y, the pharmacokinetics and tolerance of the new anxiolytic drug alpidem (SL80.0342) and its three major metabolites were studied after single doses of 25, 50, 100 and 200 mg. Plasma concentrations of alpidem (in 20 subjects) and metabolites (in 6 subjects) were measured by HPLC over a period of 54 h after dosing. Cmax, tmax and AUC(0–54) and, when possible, t1/2 were determined for alpidem and metabolites and the dose linearity of the parameters was investigated. The time to peak of alpidem was dose independent in most subjects and was short (1–4 h); the mean values at the four dosing levels were 1.9, 1.7, 1.6 and 1.8 h. The peak concentration increased with the dose, the mean values being 17, 34, 88 and 115 ng · ml−1, respectively. In 50% of the subjects cmax tended to stabilize between the 100 and 200 mg dose. Dose linearity was also present for the AUC, which plateaued between the 100 and 200 mg dose in only 3 out of 20 subjects; the mean AUC was 119, 281, 669 and 1117 ng · ml−1 · h, respectively. The apparent half-life of elimination appeared to be dose independent, mean values at the increasing dosing levels being 18.7, 19.9, 18,1 and 17.9 h. A similar relationship between the kinetics parameters and dose of the alpidem was observed for the metabolites SL83.0912, SL80.0522 and SL83.0725. The formation of metabolites was not saturated as their AUCs relative to corresponding alpidem AUCs were not dose related. Thus the kinetics of alpidem and its three major metabolites were linear after doses of 25 to 200 mg. The drug was well tolerated by most of the subjects. Sedation and dizziness occurred mainly after the 100 and 200 mg doses.
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  • 61
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    European journal of clinical pharmacology 43 (1992), S. 67-75 
    ISSN: 1432-1041
    Keywords: Morphine ; Patient-controlled analgesia ; opioids ; pharmacokinetics ; bolus-elimination-transfer ; computer-assisted continuous infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Bone marrow transplant patients having severe, prolonged oral mucositis pain (expected to last for one to three weeks) used a computer-controlled infusion system to self-administer morphine for pain control. Individual patient pharmacokinetic information, derived from a pretreatment bolus morphine dose, was used in a new bolus-elimination transfer algorithm to produce rapid adjustments of steady plasma morphine concentrations when the patient requested more or less drug. We evaluated the performance characteristics (bias and precision) of this pharmacokinetically based patient-controlled analgesic infusion system (PKPCA) in a group of 15 cancer patients over six to 14 days. Although we found a three- to fivefold pharmaco-kinetic variability in the tailoring morphine dose data, the PKPCA system was free of systematic bias (insignificant overall prediction error) during the patient-controlled infusions in this study population. The absolute prediction error was 19.9% for the group on the first study day and 25.6% over the entire study period (aggregate results; 6–14 days of continuous use). Two-thirds of the patients exhibited no bias throughout the study period, and individual bias in the others was symmetrically distributed (three patients with underpredictions and two overpredicted). Magnitude of prediction error during the patient-controlled morphine infusions was not related to the magnitude of pharmacokinetic deviation of individual subjects from group parameters. Our results indicate that this PKPCA system provides accurate control of plasma morphine concentration when used by patients to self-administer opioid for prolonged pain relief continuously over 1 to 2 weeks. Use of individual pharmacokinetic information, instead of population parameters, may account for superior performance characteristic of this computer-assisted continuous drug infusion system.
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  • 62
    ISSN: 1432-1041
    Keywords: Indomethacin ; steady-state ; pharmacokinetics ; elderly
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The steady-state pharmacokinetic profile of indomethacin was examined in twelve healthy volunteers (4 m, 8 f; 20–34 y) and in 12 elderly subjects (7 m, 5 f; 70–88 y). Two formulations of indomethacin were examined, providing duplicate data for each subject group. The subjects received each formulation of indomethacin (25 mg tid) for 6 days in a single blind crossover fashion. On day 7, after an overnight fast, a final 25 mg dose of indomethacin was given and plasma concentrations measured over the following 12 h. Kinetic parameters Cpmin, tmx and AUC (0–12 h) were determined. There were no differences in the pharmacokinetic parameters between young and elderly subjects or between data for the two formulations of indomethacin. AUC values (μg · ml−1 · h), for example, for the two formulations in the young subjects were 5.85 and 6.85 while the values for the elderly subjects were 6.55 and 6.50 respectively. When each treatment period was considered independently there was a significant difference between young and elderly subjects with regard to compliance. The rates of non compliance (over and under compliance) using a capsule count technique were, however, low with a mean maximum value of 5.8% being recorded for the elderly subjects.
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  • 63
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    European journal of clinical pharmacology 41 (1991), S. 449-452 
    ISSN: 1432-1041
    Keywords: Diabetes mellitus ; Caffeine ; pharmacokinetics ; P-450 mono-oxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Diabetes may alter the pharmacokinetics of aminopyrine and antipyrine, which are used to assess liver function. Caffeine has recently been used to test liver function, but the effect of diabetes on caffeine kinetics is not known. The kinetics of caffeine has been examined in patients with decompensated Type I and Type II diabetes and in two age- and sex-matched control groups. In both types of diabetes the apparent caffeine clearance, half-life, and apparent volume of distribution were similar to controls. It is concluded that decompensated diabetes does not influence the cytochrome P-448 mono-oxygenase system responsible for caffeine metabolism.
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  • 64
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    European journal of clinical pharmacology 42 (1992), S. 231-233 
    ISSN: 1432-1041
    Keywords: Isradipine ; Haemodialysis ; pharmacokinetics ; dialysability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of isradipine, a calcium-channel blocker, have been studied in eight patients on chronic haemodialysis. A single oral dose of 5 mg was administered on both a non-haemodialysis and a haemodialysis day and the plasma concentrations of isradipine were analyzed. The mean cmax, tmax, AUC, and t1/2 in plasma on the non-haemodialysis day were 5.2 ng·ml−1, 1.4 h, 23.8 ng·h·ml−1, and 3.1 h, respectively. The dialysis clearance of isradipine was negligible (5.0 ml·min−1). The t1/2 values during haemodialysis were not significantly different from those observed during the same period post dose on the non-haemodialysis day. The study demonstrates that supplemental doses of isradipine are not necessary in these patients since isradipine is not significantly removed by haemodialysis.
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  • 65
    ISSN: 1432-1041
    Keywords: Liver cirrhosis ; Spirapril ; ACE inhibitor ; pharmacokinetics ; haemodynamic effects ; liver function tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and haemodynamic effects of orally administered spirapril, a novel angiotensinconverting enzyme (ACE) inhibitor, have been investigated in patients with liver cirrhosis (n=10), in patients with chronic, non-cirrhotic liver disease (n=8) and in a control group of healthy subjects (n=16). The absorption and elimination of spirapril did not differ between patients with liver disease and control subjects. In contrast, the bioavailability of spiraprilat, the metabolite responsible for the pharmacological action of spirapril, was significantly reduced in patients (AUC 820 μg·h·l−1, 923 μg·h·l−1 and 1300 μg·h·l−1 in patients with cirrhosis, patients with non-cirrhotic liver disease and in healthy subjects, respectively. Compared to healthy subjects, cirrhotic patients had a reduced rate constant of spiraprilat formation (1.10 h−1 in patients vs. 2.00 h−1 in control subjects) while the elimination half-life of spiraprilat was not different. The effect of spirapril on diastolic blood pressure was decreased in patients with chronic liver disease as compared to the controls. Thus, the pharmacokinetics of spirapril was unchanged in patients with different types of liver disease, including cirrhosis. However, the bioavailability of spiraprilat and hypotensive effect of spirapril were reduced in patients.
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  • 66
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    European journal of clinical pharmacology 40 (1991), S. 593-597 
    ISSN: 1432-1041
    Keywords: Dopamine ; Newborns ; critically ill patients ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Dopamine is frequently used in critically ill newborn infants for treatment of shock and cardiac failure, but its pharmacokinetics has not been evaluated using a specific analytical method. Steady-state arterial plasma concentrations of dopamine were measured in 11 seriously ill infants receiving dopamine infusion, 5–20 μg · kg−1 · min−1, for presumed or proven sepsis and hypotensive shock. Steady-state concentrations of dopamine ranged from 0.013–0.3 μg/ml. Total body clearance averaged 115 ml · kg−1 · min−1. The apparent volume of distribution and elimination half life averaged 1.8 1 · kg−1 and 6.9 min, respectively. No relationship was observed between dopamine pharmacokinetics and gestational age, postnatal age or birthweight. Substantial interindividual variation was seen in dopamine pharmacokinetics in seriously ill infants, and plasma concentrations could not be predicted accurately from its infusion rate. Marked variation in clearance explains in part, the wide dose requirements of dopamine needed to elicit clinical response in critically ill newborn infants.
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  • 67
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    European journal of clinical pharmacology 40 (1991), S. 619-624 
    ISSN: 1432-1041
    Keywords: Inulin ; pharmacokinetics ; half life ; distribution ; concentration-dependent clearance ; healthy subjects ; chronic renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition of inulin was studied in 30 healthy male and 10 healthy female volunteers, and 10 patients with stable chronic renal failure (mean creatinine clearance 45 ml·min−1) following intravenous infusion of 70 mg·kg−1 over 5 min. Plasma concentrations fell rapidly initially but the rate of decline decreased continuously over 8 h and a linear terminal elimination phase could not be identified. Inulin was excreted rapidly by the subjects with normal renal function and 97.3% of the dose was recovered in the urine in 8 h. There was a progressive highly significant fall in the renal clearance of inulin after 2 h as plasma concentrations fell below about 150 mg·l−1. Six to 8 h after administration the clearance was less than 50% of the initial value in the healthy volunteers and the corresponding fall in the renal patients was 33%. The concentration-dependent renal clearance of inulin was confirmed in “step-up” and “step-down” constant infusion studies in which clearances were measured at mean plasma concentrations ranging from 35.2 to 186.7 mg·l−1. These studies virtually excluded time, changes in posture and urine flow rate as important factors. There was no statistically significant fall in clearance during the first 2 h and kinetic analysis was based on data obtained over this time. Under these conditions the mean plasma half life, volume of distribution (Vss) and total body clearance of inulin in the healthy males, healthy females and patients with chronic renal failure were 73.2, 65.5 and 172.4 min, 10.5, 9.6 and 8.81·70 kg−1 and 113.3, 111.5 and 43.3 ml·min−1·70 kg−1 respectively. There were no sex differences in any of the kinetic variables. The mechanism of the concentration-dependent clearance of inulin is unknown but the findings are consistent with saturable renal tubular reabsorption. Care is required with the use of inulin for measurement of the glomerular filtration rate by the single injection technique.
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  • 68
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    European journal of clinical pharmacology 40 (1991), S. 631-633 
    ISSN: 1432-1041
    Keywords: Mefloquine ; ampicillin ; Thai subjects ; pharmacokinetics ; enterohepatic recycling ; drug interaction ; adverse effects
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml−1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 μg·ml−1 day). These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine.
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  • 69
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    European journal of clinical pharmacology 40 (1991), S. 637-638 
    ISSN: 1432-1041
    Keywords: Roxatidine acetate ; sucraflate ; pharmacokinetics
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  • 70
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    European journal of clinical pharmacology 45 (1993), S. 357-361 
    ISSN: 1432-1041
    Keywords: Circadian rhythms ; Indomethacin ; Ketoprofen ; pharmacokinetics ; time-varying models ; nonsteroidal anti-inflammatory drugs
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A one-compartment model with first-order absorption has provided good fits to five sets of indomethacin data and four sets of ketoprofen data taken at different times of day. There was substantial variation in the model parameters with time of administration and most of the features of this variation applied equally to both drugs. From the data examined, the source of variation appears to be mainly in the absorption phase and this was confirmed using a chronokinetic analysis, in which simultaneous fits were obtained with time-variant rate parameters. However, there may also be circadian variation in protein binding. The danger of quoting parameter values for either of these two drugs based on administration at a single time of day has been illustrated, and this may well be true for other drugs.
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  • 71
    ISSN: 1432-1041
    Keywords: Gamma-hydroxybutyric acid ; pharmacokinetics ; dose-proportionality
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Gamma-hydroxybutyric acid (GHB) is effective in treatment of the alcohol and opiate withdrawal syndromes. Its absorption and disposition kinetics have been studied in 8 healthy male volunteers following oral administration of single doses of 12.5, 25 and 50 mg kg−1. The AUC increased disproportionately with the dose and so the apparent oral clearance decreased significantly as the dose was increased, whereas the terminal half-life and mean residence time increased. The peak plasma concentrations normalised to the lowest dose fell significantly with increasing doses, whilst the corresponding peak times increased. These findings suggest that both the oral absorption and the elimination of GHB are capacity-limited processes. GHB did not bind to significant extent to plasma proteins over the therapeutic concentration range. The pharmacokinetic parameters in healthy volunteers were not significantly different from those previously observed in alcohol-dependent patients with compensated alcoholic liver disease.
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  • 72
    ISSN: 1432-1041
    Keywords: Glyceryl trinitrate spray ; pharmacokinetics ; a/b-ratio ; pulmonary artery diastolic pressure ; finger pulse curve ; bioavailability
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time course and the magnitude of the effect of glyceryl trinitrate (GTN) on central venous (pulmonary artery diastolic pressure-PAPd) and peripheral arterial (a/b-ratio of the finger pulse wave) haemodynamics were compared in a randomized double-blind cross-over study in 12 patients suffering from congestive heart failure (NYHA II–III) with elevated PADd at rest (≥15 mm Hg). The data were obtained in a bioavailability study of two sprays of glyceryl trinitrate, which differed in their galenical characteristics and in the dose of GTN (0.4 mg vs. 0.8 mg). Following sublingual administration of each spray, PAPd, a/b-ratio and the plasma concentrations of GTN and its metabolites were measured up to 30 min. The relative bioavailability of GTN of the test preparation was estimated to be 157%, 161% and 147%, when calculated from the plasma concentration-time data or the integrated effect of GTN on a/b-ratio or PAPd, respectively. The mean time courses of the decrease in PAPd and the increase in the a/b-ratio of the finger pulse curve were mirror images. Thus, there was a strong correlation between the mean values of PAPd and a/b-ratio following the administration of glyceryl trinitrate. Since the slope of the relationship differed considerably between the patients, the magnitude of effect of GTN on PAPd in the individual patient could not be predicted from the changes in a/b-ratio.
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  • 73
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    European journal of clinical pharmacology 44 (1993), S. 463-466 
    ISSN: 1432-1041
    Keywords: Benazepril ; Proteinuria ; benazeprilat ; ACE inhibitor ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have investigated whether the pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride are altered with proteinuria by studying 8 patients with major proteinuria of different causes who were given a single dose of 10 mg p.o. The maximum plasma concentration of benazepril was found between 0.5 and 2 h after dosing (median 1 h). Its elimination was almost complete within 6 h. Peak plasma levels of benazeprilat, the active metabolite of benazepril, were observed between 1 and 6 h (median 2.5 h). The elimination of benazeprilat from plasma was biphasic, with mean initial and terminal half-lives of 3.0 and 17.3 h, respectively. On average, the pharmacokinetic parameters of benazepril and benazeprilat in the patients did not differ from those in a historical control group of healthy volunteers, but intersubject variability in the AUC and half-lives of benazeprilat was greater in the patients. Plasma ACE was completely inhibited from 1.5 to 6 h after dosing, and at 48 h the mean inhibition was still 42 %. Plasma renin showed substantial intersubject variation. Mean supine blood pressure (systolic/diastolic) was reduced from baseline by a maximum of 18/13 mm Hg at 6 h. Proteinuria was diminished after benazepril in 7 patients. In conclusion, the results of this study suggest that proteinuria in the nephrotic range does not require a change in benazepril dosage.
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  • 74
    ISSN: 1432-1041
    Keywords: dDAVP ; bioavailability ; gastrointestinal tract ; healthy volunteers ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absolute bioavailability of an aqueous solution of 1-deamino-8-D-arginine vasopressin (dDAVP) from different regions of the gastrointestinal (GI) tract (stomach, duodenum, jejunum, ileum, colon, rectum) has been studied in 6 healthy, male volunteers aged 24 to 35 years, followed for 12 h after each drug administration. For i. v. administration the subjects received 4 μg dDAVP. For intestinal administration 400 μg dDAVP was directly applied to six distinct sites in the GI tract via two or four channel tubes with or without a distal occlusive balloon. Biological effects were assessed and plasma and urinary levels of dDAVP were measured using a specific, sensitive RIA. Urine osmolality remained elevated and diuresis decreased for 12 h following dDAVP administration irrespective of the site of application. After i. v. administration, the half-life of elimination of dDAVP was 60.0 min, plasma clearance 1.7 ml·min−1·kg−1, amount excreted in urine 2.0 μg and renal clearance was 0.8 ml·min−1·kg−1. The mean bioavailability (f) after gastric application was 0.19% (range 0.02–0.35%). f was 0.24% after duodenal application (range 0.04–0.62%), 0.19% after jejunal (range 0.01–0.41%), 0.03% after distal ileal (range 0.01–0.08%), 0.04% after proximal colonic (range 0.01–0.12%) and 0.04% after rectal (0.01–0.10%) application. The bioavailability was significantly higher in the three upper GI regions in comparison to the three lower regions. The bioavailability of dDAVP after gastric, duodenal and jejunal application was similar to that after swallowing a tablet in a previous study. Absorption from the ileum was lower than expected and no preferential site of absorption was found.
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  • 75
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    European journal of clinical pharmacology 42 (1992), S. 171-174 
    ISSN: 1432-1041
    Keywords: Quinine ; Malaria ; pharmacokinetics ; red blood cells ; plasma ; saliva ; adverse effects
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of quinine has been studied in ten healthy adult Africans after intravenous infusion and oral ingestion of a 500 mg dose. Blood and saliva samples were collected over 48 h and quinine in plasma, red cells and saliva was determined by HPLC. Quinine was rapidly and almost completely absorbed after an oral dose, with absorption half-life of 0.53 h, a tmax of 1–3 h and a bioavailability of 88%. Analysis of the i. v. data gave an apparent volume of distribution of 3.6 1·kg−1 and a plasma clearance of 0.19 l·kg−1·h−1. The concentration-time curves for plasma, red cells and saliva had declining phases were approximately parallel, giving a similar half-life that in all three media. The half-lives after the i. v. infusion also did not different from those after oral administration. The dose was well tolerated by both methods of administration.
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  • 76
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    European journal of clinical pharmacology 42 (1992), S. 175-179 
    ISSN: 1432-1041
    Keywords: 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) ; Triflusal ; triflusal metabolite (HTB) ; pharmacokinetics ; protein binding ; ultrafiltration ; binding constant
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of the platelet anti-aggregant drug triflusal. Its binding to plasma proteins of rats and healthy volunteers in vitro and in vivo has been studied. Rats were given a single oral dose of 50 mg·kg−1 triflusal and the healthy volunteers received 300 mg as a single oral dose or a multiple dose regimen of 600 mg every 24 h and 300 mg every 8 h, both for 13 days. Protein-free HTB was obtained by ultrafiltration. Unbound and total HTB concentrations were determined by HPLC. HTB was primarily bound to albumin in plasma. The Scatchard plots suggested two types of binding sites for HTB on the albumin molecule. In rats, the binding constants (K=intrinsic affinity constant, n=number of binding sites) were K1=1.4×105 l·mol−1, n1=1.23, and K2=4.1×103 l·mol−1 and n2=3.77. The mean plasma concentration in rats after oral administration was 185 (37) μg·ml−1 (protein-free HTB: 2.44 (0.77)%). The binding constants in human plasma were K1=4.7×105 l·mol−1, n1=1.93, K2=4.3 l·mol−1 and n2=4.28. The plasma HTB concentration in man (n=8) was 35 μg·ml−1 (Cmax) after a single oral dose of triflusal 300 mg, 172.96 μg·ml−1 (Cmax·ss) during the multiple dosage regimen of 300 mg every 8 h, and 131 μg·ml−1 (Cmax·ss) during the multiple oral dose regimen of 600 mg every 24 h. Unbound HTB ranged from 0.27 to 0.43%, depending on dose. HTB had high affinity for plasma albumin, which was not saturable after therapeutic doses. It showed linear elimination.
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  • 77
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    European journal of clinical pharmacology 42 (1992), S. 181-185 
    ISSN: 1432-1041
    Keywords: Glycerol ; brain oedema ; serum ; cerebrospinal fluid ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Glycerol 50 g infused i. v. over 2 to 6 h is widely used to treat cerebral oedema in patients with acute stroke. Its transit through the blood-cerebrospinal fluid barrier in subjects with uninflamed meninges has now been examined. In 7 patients with an external ventriculostomy for occlusive hydrocephalus, each of whom was given 500 ml of a 10% solution IV over 4 h, serum and CSF were repeatedly sampled during and after the infusion and glycerol was measured enzymatically. The highest serum glycerol level of 191–923 mg/l was observed at the end of the infusion. The maximum CSF glycerol of 18.7–110.8 mg/l was attained 0–1 h after the end of the infusion. Elimination both from serum and CSF approximated a single-exponential decay; the elimination half-life from serum was 0.29–0.56 h compared to 1.03–3.68 h from CSF. In six of the seven cases there was a temporary reversal of the serum/CSF concentration gradient during glycerol elimination. The ratios of the AUCs of CSF and serum, which describe the overall penetration of glycerol into CSF, ranged from 0.09–0.31. In conclusion, the serum level of glycerol produced by giving 50 g IV glycerol over 4 h may not be sufficiently high reliably dehydrate to brain tissue in many patients, and the slow elimination of glycerol from the CSF may be related to the so-called rebound phenomenon.
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  • 78
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    European journal of clinical pharmacology 42 (1992), S. 187-191 
    ISSN: 1432-1041
    Keywords: Dipyrone ; Acetylation phenotype ; metabolism ; pharmacokinetics ; urinary excretion ; metabolite clearance
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The formation and urinary excretion of the dipyrone metabolites, methylaminoantipyrine (MAA), aminoantipyrine (AA), formylaminoantipyrine (FAA) and acetylaminoantipyrine (AAA) were determined following administration of a single oral 1.0 g dose of dipyrone to 12 healthy volunteers. The AAA/AA plasma ratio showed that 3 subjects were slow and 9 were rapid acetylators. Pharmacokinetic parameters were determined separately for each group. A good correlation was found between the plasma and urine AAA/AA ratios. The renal clearance of the four metabolites was similar for both phenotypes. A significant difference in the rate of formation of dipyrone metabolites was found for AA, 0.25 (slow) vs 0.1 ml·min−1·kg−1 (rapid), and for AAA 0.75 (slow) vs 7.53 ml·min−1·kg−1 (rapid). There were comparable differences between slow and rapid acetylators in the AUC and the urinary excretion extrapolated to infinity for AA and AAA. The present results show that the kinetics of dipyrone metabolites in plasma and urine can provide a useful measure of the activity of the enzymes involved in their production.
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  • 79
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    European journal of clinical pharmacology 42 (1992), S. 197-201 
    ISSN: 1432-1041
    Keywords: Digoxin ; Salbutamol ; serum ; skeletal muscle digoxin ; pharmacokinetics ; drug interaction ; serum potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single dose of the β2-adrenoceptor agonist salbutamol has previously been shown to decrease serum digoxin concentration in healthy volunteers. A possible explanation of the phenomenon is a β2-adrenoceptor-mediated increase in the specific binding of digoxin to skeletal muscle. The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man. Nine volunteers were studied on two occasions during salbutamol or placebo treatment. On test days salbutamol, 4 μg·kg−1·h−1 or saline was infused for 10 h, preceded and followed by four and three days, respectively, of oral administration. A single i. v. injection of digoxin 15 μg·kg−1, was given 20 min after starting the infusion. At the end of the infusion a muscle biopsy was taken from the vastus lateralis. Blood samples for the analysis of serum digoxin and potassium were repeatedly taken over 72 h. Urine was collected over a period of 24 h for determination of the renal excretion of digoxin and potassium. The serum digoxin concentration, expressed as the AUC 0–6 h was 15% lower during salbutamol infusion than during saline infusion. Salbutamol caused significantly faster elimination of digoxin from the central volume of distribution to deeper compartments. Salbutamol had no effect on the renal clearance of digoxin. The skeletal muscle digoxin concentration tended to be higher (48%) during salbutamol compared to placebo treatment. The serum potassium concentration was significantly lower after salbutamol compared to placebo, as was the rate of renal excretion of potassium. The results support the hypothesis that the salbutamol-induced decrease in serum digoxin is caused by increased distribution of digoxin to skeletal muscle (and possibly other tissues), and that this may be secondary to a β2-adrenoceptor-mediated increase in Na-K-ATPase activity.
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  • 80
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    European journal of clinical pharmacology 42 (1992), S. 203-207 
    ISSN: 1432-1041
    Keywords: Nicorandil ; pharmacokinetics ; angina pectoris ; uraemia ; adverse effects
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of oral nicorandil 20 mg 12 hourly for 9 doses was evaluated in 21 hospitalized patients with angina pectoris due to coronary heart disease and with normal and impaired renal function. Patients were divided into 3 groups based on creatinine clearance (CLCr): GROUP I (n=6) 〉 80 ml/min, GROUP II (n=8) 20–80 ml/min, and GROUP III (n=7) 〈 20 ml/min. After the first dose, the total clearance of nicorandil (CL) value did not change with increasing renal failure and so was not dependent on creatinine clearance. After the last dose CL was 51 l·h−1 in Group I, 44 l·h−1 in Group II and 56 l·h−1 in Group III, and it was not related to creatinine clearance. The percentage of the dose excreted in the urine was 0.4%. No significant difference was noted in any of the other pharmacokinetic parameters examined in the three groups, not even on comparing values obtained on the first and last days of treatment. The findings suggest that there is no need to change the dose of nicorandil in subjects with different degrees of renal failure.
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  • 81
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    European journal of clinical pharmacology 46 (1994), S. 83-85 
    ISSN: 1432-1041
    Keywords: Enuresis ; Oxybutynine chloride ; children ; pharmacokinetics ; adverse effects ; anticholinergic actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Anticholinergic adverse-effects in children treated with conventional doses of oxybutynine led us to measure plasma oxybutynine levels in children. 18 children, aged 5 to 13 y, who required treatment with oxybutynine chloride for daytime incontinence were studied. Plasma concentrations were measured on the fifth day of a course of treatment in which the dose was adapted to the child's body weight; the dose was given twice daily at 12-hour intervals. In 10 children aged between 5 and 8 y, the mean dose was 0.1 mg · kg−1. In 8 children aged between 10 and 13 years, the mean dose was 0.15 mg · kg−1. The highest concentration was usually found between 1 and 2 h after administration. The subsequent fall in concentration was rapid and after 6 h oxybutynine was no longer measurable in 14 of the children. The concentrations found were not different from those seen in adults given equivalent doses. The results show that plasma concentrations in children were not very different from those observed in adults if the dose were adapted to the body weight of the children. No special differences in paediatric use were revealed that might explain the particular adverse-effects. The results of the study argue against the dosage regimen proposed before these adverse events were detected. They strongly favour a dose adapted to the body weight of the child, with a 12-hour interval between doses.
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  • 82
    ISSN: 1432-1041
    Keywords: Steroid 5α-reductase inhibitor ; Testosterone metabolism ; MK-0434 ; pharmacodynamics ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract A four-period, two-panel, single-rising-dose study (0.1–100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5α-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h and maintained through 48 h post treatment. The maximum reduction was approximately 50 % and occurred at all doses above 5 mg (10, 25, 50 and 100 mg). MK-0434 appeared to have no effect on serum testosterone at these single doses. Rising single doses of MK-0434 were associated with an increase in Cmax and AUC but the changes were less than proportional to dose, most likely due to nonlinear absorption. MK-0434 given in single doses up to 100 mg was without significant adverse effects in healthy male volunteers. In summary, MK-0434 is a well-tolerated, potent, orally active 5α-reductase inhibitor in man.
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  • 83
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    European journal of clinical pharmacology 46 (1994), S. 261-265 
    ISSN: 1432-1041
    Keywords: Cystic fibrosis ; Cyclosporin ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Cyclosporin (CsA) is currently the main immunosuppressive agent used in organ transplantation with considerable improvement in graft survival. Oral CsA solution is highly lipophilic, and its bioavailability may be reduced in cystic fibrosis (CF) heart-lung transplant recipients with pancreatic, gastrointestinal, and hepatic insufficiency. The bioavailability of oral CsA solution in 7 CF transplant recipients (5 male and 2 female with a mean age of 27 years and a mean weight of 49 kg) and 3 non-CF heart-lung recipients (1 male and 2 female with a mean age of 41 years and a mean weight of 60 kg) was studied. Following intravenous CsA administration, the kinetic curves were similar with no significant difference in the volume of distribution and clearance of CsA demonstrated between the CF and non-CF groups. The mean daily dose of oral CsA in 7 CF subjects (23.3 mg·kg−1) was significantly higher than the 3 non-CF heart-lung recipients (4.8 mg·kg−1). The mean maximum blood concentration of CsA for the oral dose was 776 ng·ml−1 for the 7 CF subjects, which was comparable with the mean peak values of 789 ng·ml−1 for the 3 non-CF control subjects. Poor enteral absorption of CsA probably accounts for the significantly lower mean bioavailability in the 7 CF subjects (14.9%) compared with the 3 non-CF control subjects (39.4%). The effects on the bioavailability of oral CsA solution by pancreatic enzymes (Creon) and histamine-2 antagonist (ranitidine) were also evaluated in the 7 CF subjects. No significant difference was demonstrated.
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    European journal of clinical pharmacology 44 (1993), S. 247-251 
    ISSN: 1432-1041
    Keywords: Proguanil ; Pregnancy ; Malaria ; cycloguanil ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and whole blood concentrations of proguanil, its active metabolite cycloguanil, and the inactive metabolite 4-chlorophenyl-biguanide, were measured by HPLC in 10 healthy Karen women in the last trimester of pregnancy, following a 200 mg single oral dose of proguanil. Four of these women were restudied 2 months after delivery. The pharmacokinetic properties of proguanil were similar during and after pregnancy. Median peak plasma concentrations of proguanil during pregnancy and following delivery were 212 and 215 ng·ml−1, and occurred at 4.5 and 5 h, respectively. Mean plasma AUC values for proguanil during and following pregnancy were 94 and 98 ng·h·ml−1·kg−1, respectively. Corresponding whole blood AUC values were 361 and 396 ng·h·ml−1·kg−1. The mean elimination half lives and mean residence times of proguanil in plasma and whole blood were 12.3 and 19.6 h and 13.8 and 20.7 h respectively during pregnancy. Following pregnancy these values were 17.1 and 19.7 h for plasma and 19.7 h and 20.2 h for whole blood respectively. Mean peak plasma and whole blood concentrations of cycloguanil following pregnancy were 25 and 22 ng·ml−1 respectively. During pregnancy peak cycloguanil concentrations in both plasma and whole blood were markedly lower, 13 and 12 ng ml−1, respectively. Two pregnant women (neither of whom were restudied) were probably poor metabolisers of proguanil. The mean ratio of proguanil to cycloguanil plasma AUC was 16.7 in the third trimester of pregnancy and 7.8 following pregnancy, compared with less than 5 in previously reported studies. The concentrations of 4-chlorophenylbiguanide in both plasma and whole blood in pregnant subjects were also lower than those after pregnancy. These data show that blood concentrations of the active antimalarial metabolite cycloguanil are reduced in late pregnancy and that the currently recommended dose of proguanil could be inadequate for antimalarial prophylaxis in pregnant women.
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  • 85
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    European journal of clinical pharmacology 44 (1993), S. 265-269 
    ISSN: 1432-1041
    Keywords: Cyclosporine ; Renal transplantation ; pharmacokinetics ; intraindividual variation ; circadian variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intraindividual variability and circadian variation of oral cyclosporine (CsA) pharmacokinetics were studied over 24 h in 18 renal transplant recipients at steady state, and in 10 of the patients during a second 24 h period. The absolute percentage intraindividual difference in daytime AUC (0–12 h) ranged from 2% to 54% (mean 30%), and the corresponding variability in nighttime AUC (0–12 h) ranged from 5% to 80% (mean 34%). The pharmacokinetic variables t1/2, tmax and Cmax were more variable than the AUC (0–12 h) both during the day and at night. The evening trough level was significantly lower than the morning trough level; 185 ng · ml−1 versus 223 ng · ml−1. This, together with a significantly longer t1/2 in the night than the day, suggested circadian variability in the pharmacokinetics of CsA. In a separate retrospective study in 162 renal transplant recipients given CsA by constant intravenous infusion, repeated CsA blood concentration measurements at steady state showed lower concentrations during the day than the night, suggesting higher CsA clearance during daytime. It is concluded that CsA pharmacokinetics in renal transplant recipients, besides the well-known interindividual variability, also displays large intraindividual variability as well as circadian variation. Our findings further emphasize the necessity and difficulty of pharmacological monitoring in the clinical use of CsA in organ transplantation.
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    European journal of clinical pharmacology 44 (1993), S. 301-302 
    ISSN: 1432-1041
    Keywords: Adriamycin ; Haemodialysis ; adriamycinol ; pharmacokinetics ; moment analysis
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    European journal of clinical pharmacology 44 (1993), S. 305-306 
    ISSN: 1432-1041
    Keywords: Atenolol ; bioavailability ; intestinal absorption ; pharmacokinetics
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    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We investigated the dose proportionality after the intake of oral atenolol 25, 50, 100 and 150 mg. Standard tablets were taken by 8 healthy volunteers in randomised order of doses. The area under the curve divided by dose did not differ between the doses, indicating that the absorption of this hydrophilic compound, with known incomplete bioavailability, was constant over the range tested.
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  • 88
    ISSN: 1432-1041
    Keywords: Esmolol ; β1-Adrenoceptor antagonist ; tricresylphosphate ; pharmacokinetics ; effect kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The effects of esmolol at different rates of infusion (100, 250 and 500 μg·kg−1 BW·min−1) were compared with β-adrenoceptor occupancy (β1 and β2, estimated by a subtype selective radioreceptor assay) and plasma concentrations of esmolol and its acid metabolite were measured by HPLC. Up to a rate of infusion of esmolol of 500 μg·kg−1 BW·min−1 there was a maximal β1-receptor occupancy of 84.7% while β2-receptor occupancy was below the detection limit; confirming the β1 selectivity of esmolol. Exercise-induced increases in heart rate and systolic blood pressure were reduced by esmolol in a dose-dependent manner. The estimated EC50 values of rate of infusion for the reduction in heart rate and systolic blood pressure during exercise were 113 and 134 μg·kg−1 BW · min−1, respectively. Additionally, heart rate and systolic blood pressure were reduced moderately at rest. Because of the short elimination half-life of esmolol caused by the rapid hydrolysis to its acid metabolite, 45 min after end of infusion high plasma concentrations of the metabolite (maximally 80 μg·ml−1) but no esmolol were detectable. Since no in vivo effects have been observed, despite the presence of high plasma concentrations of the metabolite, the metabolite did not participate in the observed effects up to an infusion rate of esmolol of 500 μg·kg−1 BW·min−1. The plasma concentrations of antagonist detected by radioreceptor assay and plasma concentrations of esmolol detected by HPLC showed a good correlation (r=0.97). Since the cardiovascular effects, determined before and 45 min after termination of infusion of esmolol were similar, it can be concluded that the observed effects on heart rate and systolic blood pressure are exclusively mediated by esmolol.
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  • 89
    ISSN: 1432-1041
    Keywords: Ramipril ; Piretanide ; pharmacokinetics ; pharmacodynamics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The pharmacokinetics and pharmacodynamics of single oral doses of 5 mg ramipril and 6 mg piretanide administered separately and in combination were determined in a single blind, randomised, 3-period cross-over study in 24 healthy male volunteers. The peak plasma concentrations of ramipril and ramiprilat increased slightly (from 11.9 to 14.8 ng/ml, and from 6.39 to 8.96 ng/ml, respectively) as did the area under the plasma concentration-time curve of ramipril (0–4 h) and ramiprilat (0–24 h) (from 15.8 to 19.8 ng·ml−1·h, and from 63.4 to 74.6 ng·ml−1·h, respectively). The urinary excretion of ramiprilat also rose (from 6.82 to 7.73 % of dose) following simultaneous treatment with piretanide. These effects were probably due to reduced first-pass metabolism of ramipril/ramiprilat to inactive metabolites. The blood pressure lowering effect, the time course of inhibition of ACE activity in plasma and the concentration-response relationship for the inhibition of plasma ACE activity were not affected by piretanide. The peak plasma concentration of piretanide was somewhat reduced (from 285 to 244 ng/ml) following simultaneous treatment with ramipril. No other pharmacokinetic parameter was affected. Piretanide increased urine flow, and sodium, chloride and potassium excretion, especially during the first 2 hours following administration. These pharmacodynamic parameters were not affected by ramipril. Thus, simultaneous administration of single oral doses of ramipril and piretanide caused modest changes in the peak and average plasma concentrations of both drugs, which did not lead to detectable alterations in the pharmacodynamic parameters measured in healthy volunteers.
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  • 90
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    European journal of clinical pharmacology 46 (1994), S. 573-574 
    ISSN: 1432-1041
    Keywords: Standard deviation ; Arithmetic mean ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
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  • 91
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    European journal of clinical pharmacology 46 (1994), S. 565-567 
    ISSN: 1432-1041
    Keywords: Phenytoin ; Saliva ; therapeutic drug monitoring ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The effect of atropine-induced reductions in saliva flow rate on saliva phenytoin concentrations were evaluated in a randomised placebo-controlled crossover study in a group of epileptic patients stabilised on the drug. Pretreatment with atropine caused significant reductions in saliva flow rates during the first 4 h, compared to saline. The AUC0–4 h for saliva flow rate was significantly reduced by atropine (245 g vs 327 g) and the saliva phenytoin AUC0–4 h was significantly increased (5.6 μg · ml−1 · h vs 4.5 μg · ml−1 · h) without affecting plasma phenytoin concentrations. The saliva/plasma phenytoin AUC0–4 h ratio was therefore significantly increased by atropine (0.15 vs 0.12). However, there was a poor correlation between saliva/plasma phenytoin concentration ratios and saliva flow rates for the two treatments in the individual patients (correlation coefficient ranged from 0.25 to 0.65). These findings demonstrate that saliva phenytoin concentrations are increased by reductions in saliva flow rate. Caution is therefore required when saliva phenytoin concentrations are used for therapeutic monitoring in the presence of factors which may affect saliva flow rate.
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  • 92
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    European journal of clinical pharmacology 47 (1994), S. 61-65 
    ISSN: 1432-1041
    Keywords: Cyclosporine A ; kidney transplant ; nephrotic syndrome ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The pharmacokinetic parameters of cyclosporine (CsA) were determined in 23 kidney transplant recipients and 19 children with nephrotic syndrome, after intravenous and oral administration. The mean bioavailability was 39 %, blood clearance was 0.55 l · h-1 · kg-1 and volume of distribution at steady-stade was 2.77 l · kg-1. The absorption profile was monophasic (67 %), biphasic (29 %) or poor (4 %). The maximum blood concentration of CsA was significantly higher in children with a monophasic profile than in children with a biphasic profile (550 vs 380 ng · ml-1). Blood clearance was significantly higher in the transplant recipients than in the patients with nephrotic syndrome (0.65 vs 0.43 l · h-1 · kg-1. Although age, haematocrit, creatinine clearance, serum albumin and cholesterol differed between the two groups, only haematocrit and creatinine clearance were significantly (negatively) correlated with CsA clearance.
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  • 93
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    European journal of clinical pharmacology 47 (1994), S. 81-84 
    ISSN: 1432-1041
    Keywords: Dihydrotachysterol ; bioavailability ; pharmacokinetics ; human ; HPLC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The bioavailability of four preparations containing dihydrotachysterol (DHT2) was tested in two separate trials with administration of single, oral doses of 1 mg per individual. The relative bioavailability of corresponding preparations (capsules vs capsules and oral solution vs oral solution) was tested in a randomised, crossover pattern within the same group of volunteers. Two different groups of 24 healthy volunteers took part in each trial. Solution and capsule bioavailability was also compared inter-individually. A new sensitive HPLC-method (quantification limit 0.5 ng · ml-1) was used for the measurement of DHT2 concentration in serum. Three of the preparations tested had a similar bioavailability (mean AUC values of 195.5–223 ng · h · ml-1); the bioavailability of the fourth preparation (A.T.10 oral solution) was considerably lower (mean AUC value 111.5 ng · h · ml-1). The present dosage recommendations of all four preparations are identical. A new dosage recommendation is thus required for the oral solution with low bioavailability (A.T.10).
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  • 94
    ISSN: 1432-1041
    Keywords: Doxycycline ; bioavailability ; pH dependent absorption ; pharmacokinetics ; carrageenate ; adverse events
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The effect of increased gastric pH (obtained by pre-treatment with omeprazole) on the bioavailability of doxycycline monohydrate and doxycycline carrageenate has been investigated in 24 healthy volunteers, using an open, randomised, four-treatment, four-period, crossover, 2×2 factorial design. Each subject received a single dose of 100 mg of each of the doxycycline formulations with and without pre-treatment with omeprazole (40 mg daily for 7 days). The two formulations were bioequivalent (rate and extent) during fasting without omeprazole pre-treatment, whereas after omeprazole, the monohydrate showed a highly significant decrease in bioavailability (38% for AUC and 45% for Cmax) compared to the carrageenate formulation, which was not affected by prior administration of omeprazole. Many of the subjects did not reach a therapeutic plasma level of doxycycline during the combination of omeprazole and doxycycline monohydrate, and most adverse events (mainly gastrointestinal) were reported after this combination. As large populations of patients have a high gastric pH due to frequent use of H2-blockers, proton pump inhibitors and antacids, as well as to physiological achlorhydria, the decreased absorption of doxycycline monohydrate may well have a clinical impact, for example when the patients are treated with tetracyclines for an infection.
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  • 95
    ISSN: 1432-1041
    Keywords: Medifoxamine ; pharmacokinetics ; pharmacodynamics ; elderly volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The pharmacokinetics and psychomotor effects of medifoxamine, a 5 HT reuptake inhibitory antidepressant, were studied in healthy elderly volunteers after single and multiple dosing. The elimination half life (t1/2z) after single doses of 300 mg was 2.8 h — almost identical to that found in young volunteers. After seven days of dosing at 100 mg three times daily the mean corrected AUC after 300 mg significantly increased from 1.04 to 1.34 mg.h.l−1 and t1/2z increased to 4.0 h (NS). There were no significant changes in critical flicker fusion frequency, symbol digit substitution, continuous attention or choice reaction times.
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  • 96
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    European journal of clinical pharmacology 46 (1994), S. 179-180 
    ISSN: 1432-1041
    Keywords: Teicoplanin ; haemodialysis ; renal failure ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
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  • 97
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    European journal of clinical pharmacology 46 (1994), S. 237-242 
    ISSN: 1432-1041
    Keywords: Metoprolol ; bioavailability ; bioequivalence ; receptor binding assay ; pharmacokinetics ; sustained release formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The bioavailability and pharmacodynamic bioequivalence of a conventional and an experimental sustained-release formulation of 100 mg metoprolol tartrate were studied in a randomised cross-over study in seven healthy volunteers by assessing over 24 h the plasma kinetics of R,S-metoprolol, its β1-adrenoceptor binding component, and by determining the extent to which the active drug moiety in plasma occupied rabbit lung β1-and rat reticulocyte β2-adrenoceptors. The formulations differed markedly in their kinetic characteristics: the peak plasma concentration (Cmax) of R,S-metoprolol after administration of the conventional formulation was 140 ng·ml−1, (n=7) and it was approximately one-third of that after the sustained-release formulation, 49 ng·ml−1, (n=6); the AUC0–24 h-values for the formulations were 700 and 310 ng·h·ml−1, respectively. The Cmax for the β1-adrenoceptor binding component of metoprolol was 180 ng·ml−1 (n=7) after administration of the conventional, and 74 ng·ml−1 after administration of the sustained-release formulation. The corresponding AUC0–24 h-values for the receptor binding component were 920 and 470 ng·h·ml−1 (n=7). Thus, the kinetic differences between R,S-metoprolol and the β1-receptor binding component were considerable and they were affected by the type of formulation. In general, after administration of the sustained-release formulation, the percentage β1- and β2-adrenoceptor occupancy of metoprolol in plasma was 5–15% less than after administration of the conventional formulation. At 0.5–1.5 h after drug intake the average β1-adrenoceptor occupancy of the conventional formulation varied between 80–90% and that of the sustained release formulation between 20–76%. At these times the differences in receptor occupancy were significant; at 0.5–2 h after drug intake the average β2-adrenoceptor occupancy of the conventional formulation varied from 20–30%, and that of the sustained-release formulation was 2–17%. At other times the difference in receptor occupancy between the formulations was not significant. The results demonstrate that plasma concentration-kinetics were more discriminating than β-adrenoceptor-binding in analysing bioequivalence. It was possible to determine the bioavailability of the active ingredient of metoprolol and to study pharmacodynamic bioequivalence by using receptor binding assays.
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  • 98
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    European journal of clinical pharmacology 46 (1994), S. 575-575 
    ISSN: 1432-1041
    Keywords: Renal clearance ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
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  • 99
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    European journal of clinical pharmacology 47 (1994), S. 75-79 
    ISSN: 1432-1041
    Keywords: Diltiazem ; Angina pectoris ; controlled release formulation ; metoprolol ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Diltiazem CR tablets 120 mg b.i.d. for 1 week were compared with plain tablets 60 mg q.i.d. in 13 healthy male volunteers in a study of pharmcokinetic variables. Their antianginal efficacy was also compared in 23 patients with stable angina pectoris who were already on metoprolol. Both studies were of randomised, cross over design, and the clinical study was double blind. The pharmacokinetic variables of the two formulations were very similar except for the longer tmax of 4.4 h for diltiazem CR in comparison to 2.9 h for the plain tablets. The mean relative bioavailability of diltiazem CR in comparison with plain tablets was 1.14. The clinical study showed that after four weeks on diltiazem CR 120 mg b.i.d. or diltiazem plain tablets 60 mg q.i.d. in addition to metoprolol, there were significant decreases in weekly anginal attacks from 11 to 5 attacks/week, the number of nitroglycerin tablets consumed from 6 to 3 tablets/week, and an increase in the maximum workload from 116 to 126 and 123 W for diltiazem CR and plain diltiazem tablets, respectively, as compared to placebo. Five of the patients were angina free during diltiazem treatment. No difference in antianginal efficacy between the two preparations was seen. It was concluded that CR 120 mg b.i.d. appears bioequivalent to plain diltiazem tablets 60 mg q.i.d.
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  • 100
    ISSN: 1432-1041
    Keywords: Oxcarbazepine ; 10,11-dihydro-10-hydroxy-carbamazepine ; renal impairment ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We have studied the effect of renal impairment on the pharmacokinetics of oxcarbazepine, its active monohydroxy-metabolite (which predominates in plasma), their glucuronides, and the inactive dihydroxy-metabolite after a single oral dose of oxcarbazepine (300 mg). Six subjects with normal renal function and 20 patients with various degrees of renal impairment participated. The mean areas under the plasma concentration-time curves of oxcarbazepine and its monohydroxy-metabolite were 2–2.5-times higher in patients with severe renal impairment (CLCR〈10 ml·min−1) than in healthy subjects. The apparent elimination half-life of the monohydroxy-metabolite [19 (SD 3) h] in these patients was about twice that in healthy subjects. The effect of renal impairment on the plasma concentrations of glucuronides was more marked. The renal clearances of the unconjugated monohydroxy-metabolite and its glucuronides (the main compounds recovered in urine) correlated well with creatinine clearance. The maximum target dose in patients with slight renal impairment (CLCR〉30 ml·min−1) should not be changed. In patients with moderate renal impairment (CLCR10–30 ml·min−1) it should be reduced by 50%. In patients with severe renal impairment (CLCR〈10 ml·min−1), the glucuronides of oxcarbazepine and its monohydroxy-metabolite are likely to accumulate during repeated administration, and dosage adjustment of oxcarbazepine in these patients could not be proposed from this single administration study.
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