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  • 1
    Publication Date: 2013-01-12
    Description: We document that China's One-Child Policy (OCP), one of the most radical approaches to limiting population growth, has produced significantly less trusting, less trustworthy, more risk-averse, less competitive, more pessimistic, and less conscientious individuals. Our data were collected from economics experiments conducted with 421 individuals born just before and just after the OCP's introduction in 1979. Surveys to elicit personality traits were also used. We used the exogenous imposition of the OCP to identify the causal impact of being an only child, net of family background effects. The OCP thus has significant ramifications for Chinese society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, L -- Erkal, N -- Gangadharan, L -- Meng, X -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):953-7. doi: 10.1126/science.1230221. Epub 2013 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Econometrics, Monash University, Clayton, Victoria 3800, Australia. lisa.cameron@monash.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23306438" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Altruism ; Anxiety Disorders ; *Attitude ; *Behavior ; China ; Competitive Behavior ; Family ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; Male ; Only Child/*psychology ; *Personality ; Risk-Taking ; Trust ; Urban Population
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2013-03-23
    Description: Glycosylated alpha-dystroglycan (alpha-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least eight proteins are critical to glycosylate alpha-DG, but many genes mutated in WWS remain unknown. To identify modifiers of alpha-DG, we performed a haploid screen for Lassa virus entry, a hemorrhagic fever virus causing thousands of deaths annually that hijacks glycosylated alpha-DG to enter cells. In complementary screens, we profiled cells for absence of alpha-DG carbohydrate chains or biochemically related glycans. This revealed virus host factors and a suite of glycosylation units, including all known Walker-Warburg genes and five additional factors critical for the modification of alpha-DG. Our findings accentuate the complexity of this posttranslational feature and point out genes defective in dystroglycanopathies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919138/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919138/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jae, Lucas T -- Raaben, Matthijs -- Riemersma, Moniek -- van Beusekom, Ellen -- Blomen, Vincent A -- Velds, Arno -- Kerkhoven, Ron M -- Carette, Jan E -- Topaloglu, Haluk -- Meinecke, Peter -- Wessels, Marja W -- Lefeber, Dirk J -- Whelan, Sean P -- van Bokhoven, Hans -- Brummelkamp, Thijn R -- AI057159/AI/NIAID NIH HHS/ -- AI081842/AI/NIAID NIH HHS/ -- R01 AI081842/AI/NIAID NIH HHS/ -- U54 AI057159/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):479-83. doi: 10.1126/science.1233675. Epub 2013 Mar 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23519211" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Cell Line ; Dystroglycans/*metabolism ; Female ; Glycosylation ; Haploidy ; Host-Pathogen Interactions/*genetics ; Humans ; Infant ; Lassa Fever/*genetics/virology ; Lassa virus/*physiology ; Male ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Mutation ; Pedigree ; Proteome/*metabolism ; *Virus Internalization ; Walker-Warburg Syndrome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2013-05-25
    Description: Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces beta-amyloid (Abeta) levels and plaque burden in two mouse models of Abeta deposition in Alzheimer's disease (AD). We now report that, although bexarotene reduces soluble Abeta40 levels in one of the mouse models, the drug has no impact on plaque burden in three strains that exhibit Abeta amyloidosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Veeraraghavalu, Karthikeyan -- Zhang, Can -- Miller, Sean -- Hefendehl, Jasmin K -- Rajapaksha, Tharinda W -- Ulrich, Jason -- Jucker, Mathias -- Holtzman, David M -- Tanzi, Rudolph E -- Vassar, Robert -- Sisodia, Sangram S -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-f. doi: 10.1126/science.1235505.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704555" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2013-09-28
    Description: The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feeding has not been defined. We observed that inhibitory synaptic inputs from the extended amygdala preferentially innervate and suppress the activity of LH glutamatergic neurons to control food intake. These findings help explain how dysregulated activity at a number of unique nodes can result in a cascading failure within a defined brain network to produce maladaptive feeding.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131546/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131546/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jennings, Joshua H -- Rizzi, Giorgio -- Stamatakis, Alice M -- Ung, Randall L -- Stuber, Garret D -- AA011605/AA/NIAAA NIH HHS/ -- AA022234/AA/NIAAA NIH HHS/ -- DA032750/DA/NIDA NIH HHS/ -- DA034472/DA/NIDA NIH HHS/ -- F31 DA034472/DA/NIDA NIH HHS/ -- NS007431/NS/NINDS NIH HHS/ -- P30 NS045892/NS/NINDS NIH HHS/ -- P50 AA011605/AA/NIAAA NIH HHS/ -- R01 DA032750/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2013 Sep 27;341(6153):1517-21. doi: 10.1126/science.1241812.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24072922" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Amygdala/physiology ; Animals ; Bacterial Proteins/genetics/metabolism ; Eating/*physiology ; Feeding Behavior/*physiology ; GABAergic Neurons/*physiology ; Hypothalamus/*physiology ; Luminescent Proteins/genetics/metabolism ; Male ; Mice ; Mice, Mutant Strains ; Obesity/physiopathology ; Rhodopsin/genetics/metabolism ; Septal Nuclei/physiology ; Synapses/physiology ; gamma-Aminobutyric Acid/metabolism/physiology
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2013-04-27
    Description: Color patterns of bird plumage affect animal behavior and speciation. Diverse patterns are present in different species and within the individual. Here, we study the cellular and molecular basis of feather pigment pattern formation. Melanocyte progenitors are distributed as a horizontal ring in the proximal follicle, sending melanocytes vertically up into the epithelial cylinder, which gradually emerges as feathers grow. Different pigment patterns form by modulating the presence, arrangement, or differentiation of melanocytes. A layer of peripheral pulp further regulates pigmentation via patterned agouti expression. Lifetime feather cyclic regeneration resets pigment patterns for physiological needs. Thus, the evolution of stem cell niche topology allows complex pigment patterning through combinatorial co-option of simple regulatory mechanisms.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144997/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144997/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, S J -- Foley, J -- Jiang, T X -- Yeh, C Y -- Wu, P -- Foley, A -- Yen, C M -- Huang, Y C -- Cheng, H C -- Chen, C F -- Reeder, B -- Jee, S H -- Widelitz, R B -- Chuong, C M -- AR060306/AR/NIAMS NIH HHS/ -- AR42177/AR/NIAMS NIH HHS/ -- AR47364/AR/NIAMS NIH HHS/ -- R01 AR042177/AR/NIAMS NIH HHS/ -- R01 AR047364/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1442-5. doi: 10.1126/science.1230374. Epub 2013 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23618762" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti Signaling Protein/metabolism ; Animals ; Birds/*anatomy & histology/physiology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Chickens/anatomy & histology/physiology ; Columbidae/anatomy & histology/physiology ; Feathers/*cytology/growth & development ; Female ; Galliformes/anatomy & histology/physiology ; Male ; Melanocytes/*cytology/physiology ; Models, Biological ; *Pigmentation ; Regeneration ; *Stem Cell Niche ; Stem Cells/*cytology/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2013-08-03
    Description: Whereas reward (appetitiveness) and aversiveness (punishment) have been distinguished as two discrete dimensions within psychology and behavior, physiological and computational models of their neural representation have treated them as opposite sides of a single continuous dimension of "value." Here, I show that although dopamine neurons of the primate ventral midbrain are activated by evidence for reward and suppressed by evidence against reward, they are insensitive to aversiveness. This indicates that reward and aversiveness are represented independently as two dimensions, even by neurons that are closely related to motor function. Because theory and experiment support the existence of opponent neural representations for value, the present results imply four types of value-sensitive neurons corresponding to reward-ON (dopamine), reward-OFF, aversive-ON, and aversive-OFF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fiorillo, Christopher D -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):546-9. doi: 10.1126/science.1238699.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bio and Brain Engineering, KAIST (Korea Advanced Institute of Science and Technology), Yuseong-gu, Daejeon, Republic of Korea. fiorillo@kaist.ac.kr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908236" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetitive Behavior/*physiology ; Conditioning, Classical/physiology ; Dopaminergic Neurons/*physiology ; Female ; Macaca mulatta ; Male ; Mesencephalon/cytology/*physiology ; Punishment/*psychology ; *Reward
    Print ISSN: 0036-8075
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  • 7
    Publication Date: 2013-05-25
    Description: Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer's disease (AD) that treatment of APP/PS1DeltaE9 mice with bexarotene decreased Abeta pathology and ameliorated memory deficits. We confirm the reversal of memory deficits in APP/PS1DeltaE9 mice expressing human APOE3 or APOE4 to the levels of their nontransgenic controls and the significant decrease of interstitial fluid Abeta, but not the effects on amyloid deposition.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086452/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitz, Nicholas F -- Cronican, Andrea A -- Lefterov, Iliya -- Koldamova, Radosveta -- F32AG034031/AG/NIA NIH HHS/ -- R01 AG037481/AG/NIA NIH HHS/ -- R01 AG037919/AG/NIA NIH HHS/ -- R01AG037481/AG/NIA NIH HHS/ -- R01AG037919/AG/NIA NIH HHS/ -- R21 ES021243/ES/NIEHS NIH HHS/ -- R21ES021243/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2013 May 24;340(6135):924-c. doi: 10.1126/science.1235809.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23704552" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*drug therapy/*metabolism ; Amyloid beta-Peptides/*metabolism ; Animals ; Apolipoproteins E/*metabolism ; Brain/*metabolism ; Male ; Tetrahydronaphthalenes/*pharmacology/*therapeutic use
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  • 8
    Publication Date: 2013-04-27
    Description: Leathers and Olson (Reports, 5 October 2012, p. 132) draw the strong conclusion that neurons in the monkey lateral intraparietal (LIP) cortical area encode only cue salience, and not action value, during value-based decision-making. Although their findings regarding cue salience are interesting, their broader conclusions are problematic because (i) their primary conclusion is based on responses observed during a brief interval at the beginning of behavioral trials but is extended to all subsequent temporal epochs and (ii) the authors failed to replicate basic hallmarks of LIP physiology observed in those subsequent temporal epochs by many laboratories.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045496/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045496/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newsome, William T -- Glimcher, Paul W -- Gottlieb, Jacqueline -- Lee, Daeyeol -- Platt, Michael L -- R01 MH096875/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2013 Apr 26;340(6131):430. doi: 10.1126/science.1233214.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23620037" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cues ; Decision Making/*physiology ; Male ; Motivation/*physiology ; Neurons/*physiology ; Saccades/*physiology ; *Social Values
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-03-02
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005781/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005781/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flak, Magdalena B -- Neves, Joana F -- Blumberg, Richard S -- DK0034854/DK/NIDDK NIH HHS/ -- DK044319/DK/NIDDK NIH HHS/ -- DK051362/DK/NIDDK NIH HHS/ -- DK053056/DK/NIDDK NIH HHS/ -- DK088199/DK/NIDDK NIH HHS/ -- R01 DK088199/DK/NIDDK NIH HHS/ -- R37 DK044319/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1044-5. doi: 10.1126/science.1236226.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23449586" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Autoimmunity ; Diabetes Mellitus, Type 1/*microbiology ; Female ; Gonadal Steroid Hormones/*immunology ; Intestines/*microbiology ; Male ; *Metagenome ; *Sex Characteristics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2013-02-16
    Description: Although reconsolidation opens up new avenues to erase excessive fear memory, subtle boundary conditions put constraints on retrieval-induced plasticity. Reconsolidation may only take place when memory reactivation involves an experience that engages new learning (prediction error). Thus far, it has not been possible to determine the optimal degree of novelty required for destabilizing the memory. The occurrence of prediction error could only be inferred from the observation of a reconsolidation process itself. Here, we provide a noninvasive index of memory destabilization that is independent from the occurrence of reconsolidation. Using this index, we show in humans that prediction error is (i) a necessary condition for reconsolidation of associative fear memory and (ii) determined by the interaction between original learning and retrieval. Insight into the process of memory updating is crucial for understanding the optimal and boundary conditions on reconsolidation and provides a clear guide for the development of reconsolidation-based treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sevenster, Dieuwke -- Beckers, Tom -- Kindt, Merel -- New York, N.Y. -- Science. 2013 Feb 15;339(6121):830-3. doi: 10.1126/science.1231357.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Psychology, University of Amsterdam, Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23413355" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Propanol/administration & dosage ; Amnesia/chemically induced/*psychology ; Conditioning (Psychology)/drug effects ; Fear/drug effects/*psychology ; Female ; Humans ; Learning/drug effects/*physiology ; Male ; Mental Recall/drug effects/physiology ; Models, Psychological ; Reinforcement Schedule ; Young Adult
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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