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  • United States  (155)
  • Signal Transduction  (79)
  • 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems
  • 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport
  • 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy
  • 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
  • Acoustics
  • Applied geophysics
  • Binding Sites
  • Data analysis / ~ processing
  • Fluids
  • Schussler
  • Textbook of geophysics
  • American Association for the Advancement of Science (AAAS)  (267)
  • Elsevier  (22)
  • Springer  (4)
  • Cambridge U. Press
  • Cambridge Univ. Press
  • Kluwer
  • Soc. of Exploration Geophys.
  • W.H. Freeman
  • 2020-2023
  • 2010-2014  (293)
  • 2005-2009
  • 2000-2004
  • 1980-1984
  • 2010  (293)
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  • 2020-2023
  • 2010-2014  (293)
  • 2005-2009
  • 2000-2004
  • 1980-1984
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  • 1
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    Towards an automatic monitoring system of infrasonic events at Mt. Etna: strategies for source location and modelling (2010)
    Springer
    Details
    Publication Date: 2020-11-16
    Description: Active volcanoes characterized by open conduit conditions generate sonic and infrasonic signals, whose investigation provides useful information for both monitoring purposes and studying the dynamics of explosive processes. In this work, we discuss the automatic procedures implemented for a real-time application to the data acquired by a permanent network of five infrasound stations running at Mt. Etna volcano. The infrasound signals at Mt. Etna consist in amplitude transients, called infrasound events. The adopted procedure uses a multi-algorithm approach for event detection, counting, characterization and location. It is designed for an efficient and accurate processing of infrasound records provided by single-site and array stations. Moreover, the source mechanism of these events can be investigated off-line or in near real-time by using three different models: i) Strombolian bubble; ii) resonating conduit and iii) Helmholtz resonator. The infrasound waveforms allow us to choose the most suitable model, to get quantitative information about the source and to follow the time evolution of the source parameters.
    Description: Published
    Description: 1215–1231
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Description: open
    Keywords: infrasound ; monitoring system ; Mt. Etna ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
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    Carbon dioxide degassing and thermal energy release in the Monte Amiata volcanic-geothermal area (Italy) (2010)
    Elsevier
    Details
    Publication Date: 2021-01-07
    Description: The quaternary volcanic complex of Mount Amiata is located in southern Tuscany (Italy) and represents the most recent manifestation of the Tuscan Magmatic Province. The region is characterised by a large thermal anomaly and by the presence of numerous CO2-rich gas emissions and geothermal features, mainly located at the periphery of the volcanic complex. Two geothermal systems are located, at increasing depths, in the carbonate and metamorphic formations beneath the volcanic complex. The shallow volcanic aquifer is separated from the deep geothermal systems by a low permeability unit (Ligurian Unit). A measured CO2 discharge through soils of 1.8 109 mol a 1 shows that large amounts of CO2 move from the deep reservoir to the surface. A large range in d13CTDIC ( 21.07 to +3.65) characterises the waters circulating in the aquifers of the region and the mass and isotopic balance of TDIC allows distinguishing a discharge of 0.3 109 mol a 1 of deeply sourced CO2 in spring waters. The total natural CO2 discharge (2.1 109 mol a 1) is slightly less than minimum CO2 output estimated by an indirect method (2.8 109 mol a 1), but present-day release of 5.8 109 mol a 1 CO2 from deep geothermal wells may have reduced natural CO2 discharge. The heat transported by groundwater, computed considering the increase in temperature from the infiltration area to the discharge from springs, is of the same order of magnitude, or higher, than the regional conductive heat flow (〉200 mWm 2) and reaches extremely high values (up to 2700mWm 2) in the north-eastern part of the study area. Heat transfer occurs mainly by conductive heating in the volcanic aquifer and by uprising gas and vapor along fault zones and in those areas where low permeability cover is lacking. The comparison of CO2 flux, heat flow and geological setting shows that near surface geology and hydrogeological setting play a central role in determining CO2 degassing and heat transfer patterns.
    Description: Published
    Description: 860–875
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 2.4. TTC - Laboratori di geochimica dei fluidi
    Description: 4.5. Studi sul degassamento naturale e sui gas petroliferi
    Description: JCR Journal
    Description: reserved
    Keywords: Carbon dioxide degassing ; Monte Amiata ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 3
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    Seasonal cycles of seismic velocity variations detected using coda wave interferometry at Fogo volcano, São Miguel, Azores, during 2003–2004 (2010)
    Elsevier
    Details
    Publication Date: 2020-11-12
    Description: Fogo volcano is an active central volcano, with a lake filled caldera, in the central part of São Miguel Island, Azores, whose current activity is limited to hydrothermal manifestations such as active fumarolic fields, thermal and CO2 cold springs and soil diffuse degassing areas. It is affected by important active tectonic structures, with high seismic activity and practically continuous micro-seismicity. A recurrent feature from the seismicity observed in volcanic regions is the occurrence of clusters of similar earthquakes, whose origin can be attributed to the repeated action of a similar source mechanism at the same focal area. Doublets/multiplets were identified in this study within a catalogue of small magnitude (usually 〈 3) volcano tectonic events recorded in 2003–2004 by a selection of stations around Fogo volcano. All events have been cross-correlated and pairs whose waveforms exhibited a cross-correlation coefficient equal to or higher than 0.9 were analysed using the coda-wave interferometry technique. Subtle velocity variations found between events highlight a seasonal cycle of the velocity patterns, with lower velocity in winter time and higher velocity during summer months. Those results, together with quantitative differences between the same doublets at different stations, exhibit an excellent correlation with rainfall. A seasonal effect can also be broadly seen in the seismicity occurrence, and some of the swarms recorded over the two year period occur during the wettest season or close to episodes of abundant (above average) rainfall. Moreover, temporal and spatial analysis of several swarms highlighted the lack of any mainshock–aftershock sequence and organized migration of the hypocenters. This is suggestive of a very heterogeneous stress field. Vp/Vs is found to be lower than usually observed in volcanic areas, an occurrence likely related to the presence of steamy fluid associated with the geothermal system. Taken together, these observations suggest that pore pressurisation plays a major role in controlling a considerable part of the recorded seismicity. The geothermal fluids around Fogo massif have been identified as derived from meteoric water, which infiltrates through Fogo Lake and the volcano flanks and flows from south to north on the northern flank. All those elements seem to point to a role played by rainfall in triggering seismicity at São Miguel, possibly through pressure changes at depth in response to surface rain and/or an interaction with the geothermal system.
    Description: Published
    Description: 231-246
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: velocity changes ; rainfall ; volcano seismicity ; triggered seismicity ; Azores archipelago ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 4
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    Astronomical tuning of the La Vedova High Cliff section (Ancona, Italy)—Implications of the Middle Miocene Climate Transition for Mediterranean sapropel formation (2010)
    Elsevier
    Details
    Publication Date: 2021-01-25
    Description: Continuous marine successions covering the Middle Miocene Climate Transition (MMCT; ∼15–13.7 Ma) are scarce and the lack of a high-resolution magnetobiostratigraphic framework hampers the construction of astronomically tuned age models for this time interval. The La Vedova High Cliff section, exposed along the coast of the Cònero Riviera near Ancona (Italy), is one of the few Mediterranean sections covering the critical time interval of the MMCT. Starting from an initial magnetobiostratigraphic age model, a robust astronomical tuning was constructed for the interval between 14.2 and 13.5 Ma, using geochemical element data and time series analysis. A shift in δ18O of bulk sediment towards heavier values occurs between ∼13.92 and 13.78 Ma and could be related to the Mi3b oxygen isotope event, which reflects the rapid expansion of the East Antarctic Ice Sheet in the middle Miocene. The onset of the CM6 carbon excursion is reflected in the bulk record by a rapid increase in δ13C at 13.86 Ma. Our results confirm the proposition that these events coincide with a 405-kyr minimum in eccentricity and a node in obliquity related to the ∼1.2 Myr cycle. From 13.8 Ma onwards, distinct quadruplet cycles containing sapropelitic sediments were deposited. This may suggest a causal connection between the main middle Miocene cooling step and the onset of sapropel formation in the Mediterranean.
    Description: Published
    Description: 249–261
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: Middle Miocene ; Mediterranean ; astronomical tuning ; paleomagnetism ; biostratigraphy ; environmental changes ; orbital forcing ; sapropels ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 5
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    Tornillos at Vulcano: Clues to the dynamics of the hydrothermal system (2010)
    Elsevier
    Details
    Publication Date: 2020-11-12
    Description: The number of tornillo events has recently increased at the Vulcano Island, Italy. While only 15 tornillos were recorded during 2004–2006, 584 events occurred in 2007–2008. They were located just below La Fossa Crater at depths ranging between 0.1 and 1 km b.s.l. During two intervals in 2007–2008 increases in the number of tornillos took place at the same time as temperature and geochemical anomalies were observed. The spectral content of the tornillos, generally characterized by one–two dominant spectral peaks near 6 and 10 Hz, varied over time, with changes also noted in the quality factors. The simplest source mechanism proposed for tornillos is the free eigenvibration of a fluid volume within a crack or a conduit. Based on this model, we propose a causal relationship between the temperature and geochemical anomalies and the increases in numbers of tornillos. As the amount of hydrothermal fluids increases during the anomalies, the upward flux of fluids grows. The consequent changes in the pressure, temperature and dynamics of the system of cracks and conduits result in the generation of tornillos. Based on the fluid-filled crack/conduit model, the shallow depths of the sources and the values of the quality factors, the fluid within the resonant crack/conduit was inferred to be an ash–gas or water droplet–gas mixture. Moreover, the observed variations in the wavefield can be caused by small changes in the location of the source, in the source mechanism, or in the medium in between the source and the seismic station. Finally, another peculiar feature of tornillos is the amplitude modulation that can be explained as a result of a beating phenomenon.
    Description: Published
    Description: 377-393
    Description: 3V. Proprietà chimico-fisiche dei magmi e dei prodotti vulcanici
    Description: JCR Journal
    Description: reserved
    Keywords: Tornillos ; Vulcano Island ; Hydrothermal system ; Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 6
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    Mantle-derived carbon in Hercynian granites. Stable isotopes signatures and C/He associations in the thermomineral waters, N-Portugal (2010)
    Elsevier
    Details
    Publication Date: 2021-01-27
    Description: Na–HCO3–CO2-rich thermomineral waters issue in the N of Portugal, within the Galicia-Trás-os-Montes region, linked to a major NNE-trending fault, the so-called Penacova-Régua-Verin megalineament. Along this tectonic structure different occurrences of CO2-rich thermomineral waters are found: Chaves hot waters (67 °C) and also several cold (16.1 °C) CO2-rich waters. The δ2H and δ18O values of the thermomineral waters are similar to those of the local meteoric waters. The chemical composition of both hot and cold mineral waters suggests that water–rock reactions are mainly controlled by the amount of dissolved CO2 (g) rather than by the water temperature. Stable carbon isotope data indicate an external CO2 inorganic origin for the gas. δ13CCO2 values ranging between −7.2‰ and −5.1‰ are consistent with a two-component mixture between crustal and mantle-derived CO2. Such an assumption is supported by the 3He/4He ratios measured in the gas phase, are between 0.89 and 2.68 times the atmospheric ratio (Ra). These ratios which are higher than that those expected for a pure crustal origin (≈0.02 Ra), indicating that 10 to 30% of the He has originated from the upper mantle. Release of deep-seated fluids having a mantle-derived component in a region without recent volcanic activity indicates that extensive neo-tectonic structures originating during the Alpine Orogeny are still active (i.e., the Chaves Depression).
    Description: Published
    Description: 49-56
    Description: 4.5. Studi sul degassamento naturale e sui gas petroliferi
    Description: JCR Journal
    Description: reserved
    Keywords: CO2-rich thermomineral waters ; mantle volatiles ; isotopes ; Chaves geothermal system ; N-Portugal ; 03. Hydrosphere::03.02. Hydrology::03.02.02. Hydrological processes: interaction, transport, dynamics ; 03. Hydrosphere::03.02. Hydrology::03.02.03. Groundwater processes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
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  • 7
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    Paleomagnetic investigations on the Pleistocene lacustrine sequence of Piànico-Sèllere (northern Italy) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Piànico-Sèllere is a lacustrine succession from northern Italy that records a sequence of climatic transitions across two Pleistocene glacial stages. The intervening interglacial stage is represented by well-preserved varves with calcitic (summer) and clastic (winter) laminae. There is a tight coupling between climate-driven lithologic changes and magnetic susceptibility variations, and stable paleomagnetic components were retrieved from all investigated lithologies including the largely diamagnetic calcite varves. These components were used to delineate a sequence of magnetic polarity reversals that was interpreted as a record of excursions of the Earth’s magnetic field. Comparison of the magnetostratigraphic results with previously published data allows discussion of two possible models which have generated controversy regarding the age of the Piànico Formation. The data indicates that the Piànico Formation magnetostratigraphy correlates to geomagnetic field excursions across the Brunhes/Matuyama transition, and consequently the Piànico interglacial correlates to marine isotope stage 19. This correlation option is substantially consistent with K-Ar radiometric age estimates recently obtained from a tepha layer interbedded in the Piànico Formation. The alternative option, considering the Piànico interglacial correlative to marine isotope stage 11 within the Brunhes Chron as supported by tephrochronological dating reported in the literature, is not supported by the magnetostratigraphic results.
    Description: Published
    Description: 44-53
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: open
    Keywords: Piànico Formation ; Pleistocene ; magnetostratigraphy ; polarity excursions ; Brunhes Chron ; Southern Alps ; 04. Solid Earth::04.04. Geology::04.04.02. Geochronology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.02. Geomagnetic field variations and reversals ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 8
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    The upper lithostratigraphic unit of ANDRILL AND-2A core (Southern McMurdo Sound, Antarctica): Local Pleistocene volcanic sources, paleoenvironmental implications and subsidence in the southern Victoria Land Basin (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: We report results from the study of the uppermost 37 m of the Southern McMurdo Sound (SMS) AND-2A drill core, corresponding to the lithostratigraphic unit 1 (LSU 1), the most volcanogenic unit within the core. We present data on the age, composition, volcanological and depositional features of the volcanic sedimentary and tephra deposits of LSU 1 and discuss their source, mechanisms of emplacement and environment of deposition. Sedimentary features and compositional data indicate shallow water sedimentation for the whole of LSU 1. Most of LSU 1 deposits are a mixture of near primary volcanic material with minor exotic clasts derived from the Paleozoic crystalline basement rocks. Among volcanic materials, glassy particles are the most abundant. They were produced by mildly explosive basaltic eruptions occurring in subaerial and subaqueous environments. The Dailey Islands group, 13 km south-southwest of the SMS drill-site, has been identified as a possible source for the volcanics on the basis of similarity in composition and age. 40Ar–39Ar laser step-heating analyses on a lava sample from Juergens Island yields an age of 775 ± 22 ka. Yet because of the minimal reworking features of vitriclasts, preservation of fragile structures in volcaniclastic sediments and evidence for volcanic seamounts to the north of the Dailey Islands, it is likely that some of the material originated also from vents close to the drill-site. Evidence for local volcanic sources and for deposition of sediments in a shallow marine environment provides indications about the local paleogeography and implications for the subsidence history of the southern Victoria Land Basin from Pleistocene to Recent.
    Description: Published
    Description: 142-161
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: 3.8. Geofisica per l'ambiente
    Description: JCR Journal
    Description: reserved
    Keywords: Antarctica ; volcaniclastic sediments ; Erebus Volcanic Province ; paleoenvironment reconstruction ; Victoria Land Basin ; 04. Solid Earth::04.04. Geology::04.04.05. Mineralogy and petrology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 9
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    Mantle-derived carbon in Hercynian granites. 1 Stable isotopes signatures 2 and C/He associations in the thermomineral waters, N-Portugal (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Na–HCO3–CO2-rich thermomineral waters issue in the N of Portugal, within the Galicia-Trás-os-Montes region, linked to a major NNE-trending fault, the so-called Penacova-Régua-Verin megalineament. Along this tectonic structure different occurrences of CO2-rich thermomineral waters are found: Chaves hot waters (67 °C) and also several cold (16.1 °C) CO2-rich waters. The δ2H and δ18O values of the thermomineral waters are similar to those of the local meteoric waters. The chemical composition of both hot and cold mineral waters suggests that water–rock reactions are mainly controlled by the amount of dissolved CO2 (g) rather than by the water temperature. Stable carbon isotope data indicate an external CO2 inorganic origin for the gas. δ13CCO2 values ranging between −7.2‰ and −5.1‰ are consistent with a two-component mixture between crustal and mantle-derived CO2. Such an assumption is supported by the 3He/4He ratios measured in the gas phase, are between 0.89 and 2.68 times the atmospheric ratio (Ra). These ratios which are higher than that those expected for a pure crustal origin (≈0.02 Ra), indicating that 10 to 30% of the He has originated from the upper mantle. Release of deep-seated fluids having a mantle-derived component in a region without recent volcanic activity indicates that extensive neo-tectonic structures originating during the Alpine Orogeny are still active (i.e., the Chaves Depression).
    Description: In press
    Description: 4.5. Studi sul degassamento naturale e sui gas petroliferi
    Description: JCR Journal
    Description: open
    Keywords: CO2-rich thermomineral waters ; mantle volatiles ; isotopes ; Chaves geothermal 9 system ; 03. Hydrosphere::03.02. Hydrology::03.02.02. Hydrological processes: interaction, transport, dynamics ; 03. Hydrosphere::03.02. Hydrology::03.02.03. Groundwater processes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.03. Chemistry of waters ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems
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  • 10
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    Distal Turbidites and Tsunamigenic Landslides of Stromboli Volcano (Aeolian Islands, Italy) (2010)
    Springer
    Details
    Publication Date: 2017-04-04
    Description: On 30 December 2002, a 25-30 × 106 m3 landslide on the NW flank of Stromboli volcano produced a tsunami that caused relevant damage to the Stromboli village and to the neighboring islands of the Aeolian archipelago. The NW flank of Stromboli has been the site of several, cubic kilometer-scale, landslides during the past 13 ka. In this paper we present sedimentological and compositional data of deep-sea cores recovered from a site located about 24 km north of the island. Our preliminary results indicate that: (i) turbidity currents were effectively generated by the large-scale failures and (ii) volcanogenic turbidity current deposits retain clues of the landslide source and slope failure dynamics. By analogy with Hawaii and the Canary islands we confirm that deep-sea sediments can be effectively used to assess the age and scale of past landslide events giving an important contribution to the tsunami hazard assessment of this region.
    Description: Unpublished
    Description: -
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: reserved
    Keywords: Landslide ; turbidite ; tsunami ; Stromboli ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 11
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    Anomalous fluid emission of a deep borehole in a seismically active area of Northern Apennines (Italy) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Miano borehole of 1047 m depth is located close to the river Parma in the Northern Apennines, Italy. A measuring station is installed to observe the discharge of fluids continuously since November 2004. The upwelling fluid of this artesian well is a mixture of thermal water and methane as main components. In non-seismogenic areas, we would expect a relative constant fluid emission perhaps overlaid with long term variations from that kind of deep reservoirs during the time. However, the continuously record of the fluid emission, in particular the water discharge, the gas flow rate and the water temperature, show periods of stable values interrupted by anomalous periods of fluctuations in the recorded parameters. The anomalous variations of these parameters are of low amplitude in comparison to the total values but significant in their long-term trend. Meteorological influences of rain and barometric pressure were not detected in recorded data probably due to reservoir depth and relatively high reservoir overpressure. Influences due to the ambient temperature after the discharge were evaluated by statistical analysis. We consider that recorded changes in fluid emission parameters can be interpreted as a mixing process of different fluid components in depth by variations in pore pressure as result of seismogenic stress variation. Local seismicity was analyzed in comparison to fluid’s physico-chemical data. The analysis supports the idea of an influence to fluid transport conditions due to geodynamic processes exist. Water temperature data show frequent anomalies probably connected with possible precursory phenomena of local seismic events.
    Description: In press
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: open
    Keywords: Fluids ; Earthquakes ; Continous monitoring ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry
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  • 12
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    Mercury content and speciation in the Phlegrean Fields volcanic complex: Evidence from hydrothermal system and fumaroles (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Mercury is outstanding among the global environmental pollutants of continuing concern. Although degassing of active volcanic areas represents an important natural source of mercury into the atmosphere, still little is known about the amount and behaviour of Hg in volcanic aquifers, especially regarding its chemical speciation. In order to assess the importance of mercury emissions from active volcanoes, thermal waters were sampled in the area surrounding La Solfatara, Pozzuoli bay. This is the most active zone of the Phlegrean Fields complex (coastal area north–west of Naples), with intense hydrothermal activity at present day. Studied groundwaters show total Hg (THg) concentrations range from 56 to 171 ng/l and are lower than the 1000 ng/l threshold value for human health protection fixed by the World Health Organization (WHO, 1993). We also carefully discriminated the different aqueous species of Hg in the collected water samples. Besides, original data on Hg determination in gaseous manifestations at La Solfatara crater are also reported. We measured volcanogenic mercury concentration and Hg/Stot ratio both in the volcanic plume and in fumarolic condensates in order to better constrain Hg reactivity once emitted into the atmosphere. Data on Hg/Stot reveal that there is no significant difference between Hg volcanic composition at the venting source (fumaroles) and in near-vent diluted volcanic plumes (1.6×10−5 and 1.9×10−5, respectively), suggesting that there is limited Hg chemical processing in volcanic fumarole plumes, at least on the timescales of a few seconds investigated here. Combining the mean fumaroles Hg/CO2 mass ratio of about 1.3×10−8 (molar ratio: 2.1×10−9) with the hydrothermal soil diffuse CO2 degassing of the area, the annual Hg flux from La Solfatara is estimated as 7 kg y−1 (0.007 t y−1). Current mercury emission from La Solfatara volcano represents a very small contribution to the estimated global volcanic budget for this element, and the estimated Hg flux is considerably lower than that estimated from open-conduit active basaltic volcanoes.
    Description: Published
    Description: 250–260
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: 2.4. TTC - Laboratori di geochimica dei fluidi
    Description: 4.5. Studi sul degassamento naturale e sui gas petroliferi
    Description: JCR Journal
    Description: reserved
    Keywords: hydrothermal waters ; total mercury ; mercury speciation ; fumaroles ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
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  • 13
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    CO2 degassing at La Solfatara volcano (Phlegrean Fields): Processes affecting d13C and d18O of soil CO2 (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The soil CO2 degassing is affected by processes of isotope exchange and fractionation during transport across the soil, which can deeply modify the pristine isotope composition. This has been observed in the Solfatara volcano, upon a field survey of 110 points, where the CO2 flux was measured, together with temperature, CO2 concentration and oxygen and carbon isotopes within the soil. Furthermore, in some selected sites, the measurements were made at different depths, in order to analyze vertical gradients. Oxygen isotope composition appears controlled by exchange with soil water (either meteoric or fumarolic condensate), due to the fast kinetic of the isotopic equilibrium between CO2 and water. Carbon isotope composition is reliably controlled by transport-driven fractionation, due to the differences in diffusion coefficients between 13C16O2 and 12C16O2. We model the processes affecting CO2 transport across the soil in La Solfatara volcano by means of the Dusty Gas Model applied to a multicomponent system, to evaluate the reciprocal effect on diffusion of involved gases, i.e. 12C16O2, 13C16O2, N2 and O2 in our case. Both numerical and simplified analytical solutions of the equations based on the Dusty Gas Model are given. The modeling results fit well with the experimental data and put in evidence an isotope fractionation of carbon up to about þ4:4& with respect to the source value in the soil gas. This fractionation is independent from the entity of the CO2 flux, and occurs as long as a concentration gradient exists within the soil. On these grounds, the Dusty Gas Model can be applied to whichever diffusing gas mixture to evaluate the extent of chemical and/or isotopic fractionation that can affect ascending gases upon diffusion in any geothermal, volcanic or tectonic area.
    Description: Published
    Description: 3521-3528
    Description: 1.2. TTC - Sorveglianza geochimica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: isotope exchange ; degassing ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases ; 03. Hydrosphere::03.04. Chemical and biological::03.04.06. Hydrothermal systems ; 03. Hydrosphere::03.04. Chemical and biological::03.04.08. Instruments and techniques
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  • 14
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    Towards an Automatic Monitoring System of Infrasonic Events at Mt. Etna: Strategies for Source Location and Modeling (2010)
    Springer
    Details
    Publication Date: 2017-04-04
    Description: Active volcanoes characterized by open conduit conditions generate sonic and infrasonic signals, whose investigation provides useful information for both monitoring purposes and studying the dynamics of explosive processes. In this work, we discuss the automatic procedures implemented for a real-time application to the data acquired by a permanent network of five infrasound stations running at Mt. Etna volcano. The infrasound signals at Mt. Etna consist in amplitude transients, called infrasound events. The adopted procedure uses a multi-algorithm approach for event detection, counting, characterization and location. It is designed for an efficient and accurate processing of infrasound records provided by single-site and array stations. Moreover, the source mechanism of these events can be investigated off-line or in near real-time by using three different models: (1) Strombolian bubble; (2) resonating conduit and (3) Helmholtz resonator. The infrasound waveforms allow us to choose the most suitable model, to get quantitative information about the source and to follow the time evolution of the source parameters.
    Description: Published
    Description: 1215–1231
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Infrasound ; monitoring system ; Mt. Etna volcano ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
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  • 15
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    Magma dynamics of 2007 Stromboli effusive eruption as revealed by high precision location of seismic events. (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Stromboli is considered one of the most active volcanoes in the world, and its persistent but moderate explosive activity is only interrupted by occasional episodes of more vigorous activity accompanied by lava flows. A new effusive eruption began in late February, 2007 and was characterised by intense seismic activity throughout the whole period. The accurate seismic signals analysis showed the presence of families of events with similar waveform signatures (i.e. multiplets) located beneath the crater region. Since traditional location techniques do not allow obtaining reliable hypocentres, our analysis focused on high precision locations of the seismicity, in order to better define the source geometry of the events. Hypocentres, therefore, have been relocated considering two steps: the first, based on a robust probabilistic approach, is used to find the absolute position of the clusters; the second exploits a master-event concept for the relative location of the events. Finally, the shape of the clusters and the temporal migration of the foci were correlated with the eruptive phases. The results show that the occurrence of a cluster of events is related to the opening and closure of a vent opened in the Sciara del Fuoco slope and, in particular, to the intrusion of a dike injected by central conduit in a radial direction, whereas another cluster lies in a narrow vertical volume positioned under the crater area. The geometry of the clusters suggests a source region depicting the shallower feeding system. Overall, the results highlight that the high precision locations method is an efficient and quick tool to obtain a better understanding of the magmatic processes occurring during an ongoing eruption.
    Description: Published
    Description: 405-415
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: eruption ; high precision location ; seismic swarms ; magma dynamics ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 16
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    Geochemistry of fluids discharged over the seismic area of the Southern Apennines (Calabria region, Southern Italy): Implications for Fluid-Fault relationships (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The first comprehensive geochemical data-set of the fluids circulating over a 14,000 km2-wide seismicprone area of the Southern Apennines, Calabria Region (Italy), is presented here. The geochemical investigations were carried out with the twofold aim of constraining the origin and interactions of the circulating fluids and to investigate possible relationships with local faults. Sixty samples of both thermal and cold waters were collected, from which the dissolved gases were extracted. The geochemical features of the water samples display different types and degrees of water–rock interactions, irrespective of the outlet temperature. The calculated equilibrium temperatures of the thermal waters (60–160 C) and the low heat flow of thewhole study area, are consistent with a heating process due to deep water circulation and rapid upflow through lithospheric structures. The composition of the dissolved gases reveals that crustal-originating gases (N2 and CO2-dominated) feed all the groundwaters. The 3He/4He ratios of the dissolved He, in the range of 0.03–0.22Rac for the thermal waters and 0.05–0.63Rac for the cold waters (Rac = He isotope ratio corrected for atmospheric contamination), are mainly the result of a two-component (radiogenic and atmospheric) mixing, although indications of mantle-derived He are found in some cold waters. As the study area had been hit by 18 of the most destructive earthquakes (magnitude ranging from 5.9 to 7.2) occurring over a 280-a time span (1626–1908) in the Southern Apennines, the reported results on the circulating fluids may represent the reference for a better inside knowledge of the fault-fluid relationships and for the development of long-term geochemical monitoring strategies for the area.
    Description: Published
    Description: 540–554
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: open
    Keywords: Fluids ; Geochemistry ; Faults ; Seismicity ; 04. Solid Earth::04.02. Exploration geophysics::04.02.01. Geochemical exploration
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  • 17
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    Anomalous fluid emission of a deep borehole in a seismically active area of Northern Apennines (Italy) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Miano borehole, 1047 m deep, is located close to the river Parma in the Northern Apennines, Italy. A measuring station has been installed to observe the discharge of fluids continuously since November 2004. The upwelling fluid of this artesian well is a mixture of thermal water and CH4 as main components. In non-seismogenic areas, a relatively constant fluid emission would be expected, perhaps overlaid with long term variations from that kind of deep reservoir over time. However, the continuous record of the fluid emission, in particular the water discharge, the gas flow rate and the water temperature, show periods of stable values interrupted by anomalous periods of fluctuations in the recorded parameters. The anomalous variations of these parameters are of low amplitude in comparison to the total values but significant in their long-term trend. Meteorological effects due to rain and barometric pressure were not detected in recorded data probably due to reservoir depth and relatively high reservoir overpressure. Influences due to the ambient temperature after the discharge were evaluated by statistical analysis. Our results suggest that recorded changes in fluid emission parameters can be interpreted as a mixing process of different fluid components at depth by variations in pore pressure as a result of seismogenic stress variation. Local seismicity was analyzed in comparison to the fluid physico-chemical data. The analysis supports the idea that an influence on fluid transport conditions due to geodynamic processes exists. Water temperature data show frequent anomalies probably connected with possible precursory phenomena of local seismic events.
    Description: Published
    Description: 555–571
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: open
    Keywords: Fluids ; Seismicity ; 04. Solid Earth::04.02. Exploration geophysics::04.02.01. Geochemical exploration
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  • 18
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    Astrochronology of the Mediterranean Langhian between 15.29 and 14.17 Ma (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: An integrated high-resolution magnetobiocyclostratigraphy including radioisotopic dating and astronomical tuning is presented for the interval between 15.29 and 14.17 Ma in the marine La Vedova section in northern Italy. The natural remanent magnetization is carried by the iron sulphide greigite and the resultant magnetostratigraphy can be correlated straightforwardly to the interval ranging from C5Bn.2n to C5ADn in the Astronomically Tuned Neogene Time Scale (ATNTS2004). Spectral analysis on high-resolution magnetic susceptibility and geochemical proxy records in the depth domain and, using our magnetobiostratigraphic age model, in the time domain demonstrate that the various scales of cyclicity in the section are related to astronomical climate forcing. Starting from our initial age model, larger-scale cycles were first tuned to eccentricity. This first-order tuning was followed by tuning the basic cycle to precession and boreal summer insolation using inferred phase relations between maxima in Ca/Al, redox-sensitive elements and Ba, and minima in magnetic susceptibility, and maxima in precession and minima in obliquity and boreal summer insolation. Our astronomical ages for reversal boundaries are supported by analysis of sea floor spreading rates and should replace the existing ages in the ATNTS2004 lacking direct astronomical control. Two major steps in the geochemical proxy records, astronomically dated at 15.074 and 14.489 Ma, coincide with abrupt changes in sedimentation rate, and are the result of the combined effect of the ∼400-kyr eccentricity cycle superimposed upon a longer-term climatic or tectonic induced trend.
    Description: Published
    Description: 254–269
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: Middle Miocene ; Langhian ; Mediterranean ; astronomical tuning ; palaeomagnetism ; biostratigraphy ; environmental changes ; orbital forcing ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
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  • 19
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    Multiple resolution seismic attenuation imaging at Mt. Vesuvius (2010)
    Elsevier
    Details
    Publication Date: 2019-03-05
    Description: A three-dimensional S wave attenuation tomography of Mt. Vesuvius has been obtained with multiple measurements of coda-normalized S-wave spectra of local small magnitude earthquakes.We used 6609 waveforms, relative to 826 volcano-tectonic earthquakes, located close to the crater axis in a depth range between 1 and 4 km (below the sea level), recorded at seven 3-component digital seismic stations. We adopted a two-point ray-tracing; rays were traced in an high resolution 3-D velocity model. The spatial resolution achieved in the attenuation tomography is comparable with that of the velocity tomography (we resolve 300m side cubic cells). We statistically tested that the results are almost independent from the radiation pattern. We also applied an improvement of the ordinary spectral-slope method to both P- and S-waves, assuming that the differences between the theoretical and the experimental high frequency spectral-slope are only due to the attenuation effects. Consequently we could check the codanormalization method also comparing the S attenuation image with the P attenuation image. The images were obtained inverting the spectral data with a multiple resolution approach. Results have shown the general coincidence of low attenuation with high velocity zones. The joint interpretation of velocity and attenuation images allows us to interpret the low attenuation zone intruding toward the surface until a depth of 500m below the sea level as related to the residual part of solidified magma from the last eruption. In the depth range between −700 and −2300 images are consistent with the presence of multiple acquifer layers. No evidence of magma patches greater than the minimum cell dimension (300m) has been found. A shallow P wave attenuation anomaly (beneath the southern flank of the volcano) is consitent with the presence of gas saturated rocks. The zone characterized by the maximum seismic energy release cohincides with a high attenuation and low velocity volume, interpreted as a cracked medium.
    Description: Published
    Description: 17–32
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: reserved
    Keywords: Attenuation tomography ; Mt. Vesuvius ; Coda normalization method ; Spectral slope ; Multi resolution inversion ; 04. Solid Earth::04.06. Seismology::04.06.07. Tomography and anisotropy ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.09. Waves and wave analysis
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  • 20
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    Time-space variation of volcano-seismic events at La Fossa (Vulcano, Aeolian Islands, Italy): new insights into seismic sources in a hydrothermal system (2010)
    Springer
    Details
    Publication Date: 2020-02-24
    Description: We investigated the relationship between volcano-seismic events, recorded at La Fossa crater of Vulcano (Aeolian Islands, Italy) during 2004-2006, and the dynamics of the hydrothermal system. During the period of study, three episodes of increasing numbers of volcano-seismic events took place at the same time as geothermal and geochemical anomalies were observed. These geothermal and geochemical anomalies have been interpreted as resulting from an increasing deep magmatic component of the hydrothermal fluids. Three classes of seismic events (long period, high frequency and monochromatic events), characterised by different spectral content and various similarity of the waveforms, have been recognised. These events, clustered mainly below La Fossa crater area at depths of 0.5–1.1 km b.s.l., were space-distributed according to the classes. Based on their features, we can infer that such events at Vulcano are related to two different source mechanisms: (1) fracturing processes of rocks and (2) resonance of cracks (or conduits) filled with hydrothermal fluid. In the light of these source mechanisms, the increase in the number of events, at the same time as geochemical and geothermal anomalies were observed, was interpreted as the result of an increasing magmatic component of the hydrothermal fluids, implying an increase of their flux. Indeed, such variation caused an increase of both the pore pressure within the rocks of the volcanic system and the amount of ascending fluids. Increased pore pressures gave rise to fracturing processes, while the increased fluid flux favoured resonance and vibration processes in cracks and conduits. Finally, a gradual temporal variation of the waveform of the hybrid events (one of the subclasses of long period events) was observed, likely caused by heating and drying of the hydrothermal system.
    Description: Published
    Description: 803-816
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Volcano seismology ; Vulcano Island ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 21
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    Fault plane orientations of microearthquakes at Mt. Etna from theinversion of P-wave rise times (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: A crucial point in the analysis of tectonic earthquakes occurring in a volcanic area is the inference of the orientation of the structures along which the ruptures occur. These structures represent zones of weakness which could favor the migration of melt toward the surface and the assessment of their geometry is a fundamental step toward efficient evaluation of volcanic risk. We analyzed a high-quality dataset of 171 lowmagnitude, tectonic earthquakes that occurred at Mt. Etna during the 2002–2003 eruption. We applied a recently developed technique aimed at inferring the source parameters (source size, dip and strike fault) and the intrinsic quality factor Qp of P waves from the inversion of rise times. The technique is based on numerically calibrated relationships among the rise time of first P waves and the source parameters for a circular crack rupturing at a constant velocity. For the most of the events the directivity source effect did not allow us to constrain the fault plane orientation. For a subset of 45 events with well constrained focal mechanisms we were able to constrain the “true” fault plane orientation. The level of resolution of the fault planes was assessed through a non linear analysis based on the random deviates technique. The significance of the retrieved fault plane solutions and the fit of the assumed source model to data were assessed through a χ-square test. Most of the retrieved fault plane solutions agree with the geometrical trend of known surface faults. The inferred source parameters and Qp are in agreement with the results of previous studies
    Description: Published
    Description: 247-256
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: reserved
    Keywords: rise time ; directivity ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
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  • 22
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    High-resolution intra- and interbasinal correlation of the Danian–Selandian transition (Early Paleocene): The Bjala section (Bulgaria) and the Selandian GSSP at Zumaia (Spain) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Danian–Selandian (D–S) boundary has been identified for the first time in the Black Sea coast at Bjala (Bulgaria) based on a new integrated bio-, magneto- and cyclostratigraphic study. Several correlation criteria as established for the basal Selandian GSSP from Zumaia (Basque Basin) are evaluated. Noteworthy, is the almost complete lack of calcareous nannoplankton species Braarudosphaera bigelowi in the Bulgarian sections, a sharp decrease of which was indicated as suitable criteria for defining the D–S boundary as it occurred both at Zumaia and in the classical locations of the North Sea basin. Conversely, the second evolutionary radiation of the calcareous nannofossil genus Fasciculithus together with the occurrence of Fasciculithus tympaniformis that define the NP4/NP5 zonal boundary seem to be reliable criteria to approximate the D–S boundary. In detail, however, the best approach is to integrate biostratigraphic data within a magnetostratigraphic and/or cyclostratigraphic framework. Refinements on the placement of chron C27n at Zumaia and robust bed-by-bed correlation between several Basque sections and Bjala indicates that the D–S boundary is located 30 precession cycles (~630 ky) above C27n. In addition to the precession-related marl–limestone couplets and 100-ky eccentricity bundles recognized in the studied sections, expression of the stable 405-ky long eccentricity allows direct tuning to the astronomical solutions. A correlation of the land-based sections with previously tuned data from ODP Site1262 from the Southern Atlantic is challenged. Our choice is consistent with original tuning at Zumaia but shifts one 100-ky cycle older previous tuning from Site 1262 along the interval above C27n. Under the preferred tuning scheme the D–S boundary can be given an age of 61.641± 0.040 Ma on the La04 orbital solution.
    Description: Published
    Description: 511-533
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: Paleocene ; Magnetostratigraphy ; Orbital tuning ; Calcareous nannofossils ; Selandian GSSP ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
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  • 23
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    Nannoplankton biostratigraphic calibration of the evaporitic events in the Neogene Fortuna Basin (SE Spain) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Fortuna Basin is an example of a marginal Mediterranean basin with evaporitic sedimentation during the Late Tortonian and Messinian. This basin shows an early restriction event before the main Messinian Salinity Crisis (MSC) that allows the Tortonian Salinity Crisis (TSC) to be proposed as a tectonic uplift event isolating the eastern Betic basins. Four evaporitic events are present in the central part of the Fortuna Basin, from bottom to top: Los Baños Marls Formation (composed by Fenazar Conglomerate Bed, Lower Gypsum Member [Mb] and Sanel Mb), Tale Gypsum Formation (Fm), Chicamo Diatomites and Gypsum Cycles Fm, and Rambla Salada Gypsum Fm. The present work documents the first biostratigraphic dating based on calcareous nannoplankton of these events. The lowest occurrence (LO) of Amaurolithus primus is registered at the upper part of the Sanel Mb, below the Tale Gypsum Fm. The LOs of Amaurolithus delicatus and Reticulofenestra rotaria, which mark the base of the Messinian, occur in the lower part of the Chicamo Cycles Fm, above the Tale Gypsum Fm, the Triquetrorhabdulus rugosus-Nicklithus amplificus integrate form and the LO of Nicklithus cf. amplificus in the upper part of the Chicamo Cycles Fm. Taking into account these results, a new calibration of the available magnetostratigraphic data is presented: the Chicamo Cycles Fm were formed during the reverse chron C3Ar and the Tortonian-Messinian boundary should be found within the Tale Gypsum Fm or near the top of the Sanel Mb. The onset of the TSC, the first restriction phase of the Fortuna Basin, is represented by the Fenazar Conglomerate Bed, bottom of the Los Baños Fm, and not by the Tale Gypsum Fm, as previously considered.
    Description: Published
    Description: 201-217
    Description: 2.2. Laboratorio di paleomagnetismo
    Description: JCR Journal
    Description: restricted
    Keywords: Betic Cordillera ; Tortonian Salinity Crisis ; Calcareous nannoplankton ; Messinian ; Fortuna Basin ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
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  • 24
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    Late Matuyama climate forcing on sedimentation at the margin of the southern Alps (Italy) (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: The Pleistocene history of climate control on sedimentation in the Southern Alps-Po Plain system, northern Italy, was reconstructed using an integrated magnetostratigraphic, palynological, and petrographical approach on a 47-m-deep core. The core mainly consists of lacustrine sediments pertaining to the Bagaggera sequence, deposited at the foothills of the Southern Alps during the late Matuyama subchron (0.99-0.78 Ma). At that time, climate worsened globally and locally it caused the progradation of an alluvial fan unit onto the nearby Po Plain, triggering lake formation by damming of a tributary valley. These new data are used in conjunction with data from the literature to highlight and track the effects of climate forcing on sedimentation during the late Matuyama subchron in different orographic and geodynamic settings of the Southern Alps-Po Plain system as part of the greater Alpine area. We found that the episodes of alluvial fan and braidplam progradation observed in the southern foreland of the Alps during the late Matuyama global cooling seem broadly synchronous with the deposition of most of the so-called Gunz and Alterer Deckenschotter deposits in the northern forelands of the Alps as well as with the first major waxing of the Alpine valley glaciers, possibly around the Marine Isotope Stage 22 (~0.87 Ma).
    Description: Regione Lombardia, IREALP
    Description: Published
    Description: 832–846
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: restricted
    Keywords: Paleomagnetism ; Climate Change ; Early Pleistocene ; Italy ; Stratigraphy ; Petrography ; Palynology ; 03. Hydrosphere::03.01. General::03.01.03. Global climate models ; 04. Solid Earth::04.04. Geology::04.04.02. Geochronology ; 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
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  • 25
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    Human migration into Europe during the late Early Pleistocene climate transition (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: A critical assessment of the available magnetostratigraphic and/or radiometric age constraints on key sites bearing hominin remains and/or lithic industries from southern Europe (Italy, France, Spain) leads us to propose that the main window of early hominin presence in southern Europe is broadly comprised between the Jaramillo subchron and the Brunhes–Matuyama boundary (i.e., subchron C1r.1r, 0.99–0.78 Ma). Within the dating uncertainties, this ~200 ky time window broadly coincides with the late Early Pleistocene global climate transition that contains marine isotope stage (MIS) 22 (~0.87Ma), the first prominent cold stage of the Pleistocene. We suggest that aridification in North Africa and Eastern Europe, particularly harsh during MIS22 times, triggered migration pulses of large herbivores, particularly elephants, from these regions into southern European refugia, and that hominins migrated with them. Finally, we speculate on common pathways of late Early Pleistocene dispersal of elephants and hominins from their home in savannah Africa to southern Europe, elephant and hominin buen retiro. In particular, we stress the importance of the Po Valley of northern Italy that became largely and permanently exposed only since MIS22, thus allowing possibly for the first time in the Pleistocene viable new migration routes for large mammals and hominins across northern Italy to southern France and Spain in the west.
    Description: Published
    Description: 79-93
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: restricted
    Keywords: Pleistocene ; Magnetostratigraphy ; Hominins ; Migration ; Europe ; Galerian ; Jaramillo ; Brunhes-Matuyama ; 04. Solid Earth::04.04. Geology::04.04.02. Geochronology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.05. Geomagnetism::04.05.06. Paleomagnetism
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  • 26
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    Changes in the VLP seismic source during the 2007 Stromboli eruption (2010)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: Aim of this paper is to identify variations in Very-Long-Period (VLP) source associated with eruptive style changes at Stromboli volcano (Italy) and to retrieve information about the shallow plumbing system that sustains the eruptive activity. We have considered a dataset of 74493 VLP events recorded during the period from January through August 2007, when an effusive eruption occurred (February 27–April 2).We performed a polarization analysis of the entire dataset and divided the considered period into four sub-periods on the basis of polarization characteristics. We then located the events and selected a subset of these events by applying a location quality threshold. The high quality locations demonstrate that during the effusive eruption the VLP sources first moved downward and then moved southwestward. To retrieve information about the geometry of the structures where the source processes take place, we further consider a subset of events and estimate their source mechanisms by using a moment tensor source function (MTSF) inversion technique. Inversion of the waveforms of the VLP events that occurred on February 27 allows us to obtain information about the dynamics of different source centroids distributed along different portions of the shallow magmatic conduits. The structure defined by the locations and source mechanisms shows a greater complexity compared with previous studies and their time variations give an insight into the kinematics of the eruption.
    Description: Published
    Description: 162–171
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: stromboli ; very-long-period events ; seismic source mechanism ; volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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    National Institutes of Health. A government niche for translational medicine and drug development (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Dec 10;330(6010):1462-3. doi: 10.1126/science.330.6010.1462-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21148358" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Drug Discovery/economics/organization & administration ; Financing, Government ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research Support as Topic ; *Translational Medical Research/economics/organization & administration ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-15
    Description: Insulin-like growth factor 1 (IGF-1) induces skeletal muscle maturation and enlargement (hypertrophy). These responses require protein synthesis and myofibril formation (myofibrillogenesis). However, the signaling mechanisms of myofibrillogenesis remain obscure. We found that IGF-1-induced phosphatidylinositol 3-kinase-Akt signaling formed a complex of nebulin and N-WASP at the Z bands of myofibrils by interfering with glycogen synthase kinase-3beta in mice. Although N-WASP is known to be an activator of the Arp2/3 complex to form branched actin filaments, the nebulin-N-WASP complex caused actin nucleation for unbranched actin filament formation from the Z bands without the Arp2/3 complex. Furthermore, N-WASP was required for IGF-1-induced muscle hypertrophy. These findings present the mechanisms of IGF-1-induced actin filament formation in myofibrillogenesis required for muscle maturation and hypertrophy and a mechanism of actin nucleation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takano, Kazunori -- Watanabe-Takano, Haruko -- Suetsugu, Shiro -- Kurita, Souichi -- Tsujita, Kazuya -- Kimura, Sumiko -- Karatsu, Takashi -- Takenawa, Tadaomi -- Endo, Takeshi -- New York, N.Y. -- Science. 2010 Dec 10;330(6010):1536-40. doi: 10.1126/science.1197767.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21148390" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Cytoskeleton/*metabolism ; Actins/*metabolism ; Animals ; COS Cells ; Cercopithecus aethiops ; Hypertrophy ; Insulin-Like Growth Factor I/*metabolism ; Mice ; Mice, Inbred ICR ; *Muscle Development ; Muscle Proteins/chemistry/*metabolism ; Muscle, Skeletal/metabolism/pathology ; Myofibrils/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; Sarcomeres/*metabolism ; Signal Transduction ; Wiskott-Aldrich Syndrome Protein, Neuronal/chemistry/*metabolism ; src Homology Domains
    Print ISSN: 0036-8075
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    Bioethics. Oversight but no strict rules for synthetic biology (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Nov 26;330(6008):1166. doi: 10.1126/science.330.6008.1166-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21109641" target="_blank"〉PubMed〈/a〉
    Keywords: Bioethical Issues ; *Ethics Committees ; *Government Regulation ; Synthetic Biology/*ethics/legislation & jurisprudence ; United States
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    National Institutes of Health. Collins endorses merger of U.S. addiction research programs (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Nov 26;330(6008):1166. doi: 10.1126/science.330.6008.1166-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21109640" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Budgets ; National Institute on Alcohol Abuse and Alcoholism (U.S.)/economics/*organization ; & administration ; National Institute on Drug Abuse (U.S.)/economics/*organization & administration ; United States
    Print ISSN: 0036-8075
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    PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-02
    Description: Meiotic recombination events cluster into narrow segments of the genome, defined as hotspots. Here, we demonstrate that a major player for hotspot specification is the Prdm9 gene. First, two mouse strains that differ in hotspot usage are polymorphic for the zinc finger DNA binding array of PRDM9. Second, the human consensus PRDM9 allele is predicted to recognize the 13-mer motif enriched at human hotspots; this DNA binding specificity is verified by in vitro studies. Third, allelic variants of PRDM9 zinc fingers are significantly associated with variability in genome-wide hotspot usage among humans. Our results provide a molecular basis for the distribution of meiotic recombination in mammals, in which the binding of PRDM9 to specific DNA sequences targets the initiation of recombination at specific locations in the genome.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295902/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295902/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baudat, F -- Buard, J -- Grey, C -- Fledel-Alon, A -- Ober, C -- Przeworski, M -- Coop, G -- de Massy, B -- 03S1/PHS HHS/ -- GM83098/GM/NIGMS NIH HHS/ -- HD21244/HD/NICHD NIH HHS/ -- HL085197/HL/NHLBI NIH HHS/ -- R01 GM083098/GM/NIGMS NIH HHS/ -- R01 HD021244/HD/NICHD NIH HHS/ -- R01 HL085197/HL/NHLBI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Feb 12;327(5967):836-40. doi: 10.1126/science.1183439. Epub 2009 Dec 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique Humaine, UPR1142, CNRS, Montpellier, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20044539" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; DNA/chemistry/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/chemistry/genetics/metabolism ; Genome ; Genome, Human ; Genotype ; Histone-Lysine N-Methyltransferase/chemistry/*genetics/*metabolism ; Humans ; Meiosis/*genetics ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Phenotype ; *Recombination, Genetic ; Zinc Fingers/genetics
    Print ISSN: 0036-8075
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    Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-02-27
    Description: The beta1- and beta2-adrenergic receptors (betaARs) on the surface of cardiomyocytes mediate distinct effects on cardiac function and the development of heart failure by regulating production of the second messenger cyclic adenosine monophosphate (cAMP). The spatial localization in cardiomyocytes of these betaARs, which are coupled to heterotrimeric guanine nucleotide-binding proteins (G proteins), and the functional implications of their localization have been unclear. We combined nanoscale live-cell scanning ion conductance and fluorescence resonance energy transfer microscopy techniques and found that, in cardiomyocytes from healthy adult rats and mice, spatially confined beta2AR-induced cAMP signals are localized exclusively to the deep transverse tubules, whereas functional beta1ARs are distributed across the entire cell surface. In cardiomyocytes derived from a rat model of chronic heart failure, beta2ARs were redistributed from the transverse tubules to the cell crest, which led to diffuse receptor-mediated cAMP signaling. Thus, the redistribution of beta(2)ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nikolaev, Viacheslav O -- Moshkov, Alexey -- Lyon, Alexander R -- Miragoli, Michele -- Novak, Pavel -- Paur, Helen -- Lohse, Martin J -- Korchev, Yuri E -- Harding, Sian E -- Gorelik, Julia -- 084064/Wellcome Trust/United Kingdom -- BB/D020875/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- G0500373/Medical Research Council/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2010 Mar 26;327(5973):1653-7. doi: 10.1126/science.1185988. Epub 2010 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20185685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Compartmentation ; Cell Membrane/*metabolism/ultrastructure ; Chronic Disease ; Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cytosol/metabolism ; Fluorescence Resonance Energy Transfer ; Heart Failure/*metabolism/*pathology ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Microscopy/methods ; Myocytes, Cardiac/*metabolism/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, beta-1/genetics/metabolism ; Receptors, Adrenergic, beta-2/genetics/*metabolism ; Sarcolemma/*metabolism/ultrastructure ; Signal Transduction
    Print ISSN: 0036-8075
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    Sowing the seeds of soil conservation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Henry -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1078. doi: 10.1126/science.327.5969.1078-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20185709" target="_blank"〉PubMed〈/a〉
    Keywords: Conservation of Natural Resources/*legislation & jurisprudence ; *Soil ; United States
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    Profile: Dolores Piperno. In archaeobotanist's hands, tiny fossils yield big answers (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2010 Jul 2;329(5987):28-9. doi: 10.1126/science.329.5987.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20595594" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Americas ; Animals ; Archaeology/history ; Botany/history ; Diet ; *Fossils ; History, 20th Century ; History, 21st Century ; History, Ancient ; Hominidae ; Humans ; *Plants, Edible ; Radiometric Dating ; Starch/ultrastructure ; United States ; Zea mays
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    Bioethics. U.S. panel weighs guidelines for synthetic biology (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Jul 16;329(5989):264-5. doi: 10.1126/science.329.5989.264-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20647432" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Bioengineering/*ethics ; *Bioethical Issues ; *Guidelines as Topic ; United States
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    The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-23
    Description: CD4(+)Foxp3(+) regulatory T (T(reg)) cells are important for maintaining immune tolerance. Understanding the molecular mechanism that regulates T(reg) differentiation will facilitate the development of effective therapeutic strategies against autoimmune diseases. We report here that the SUMO E3 ligase PIAS1 restricts the differentiation of natural T(reg) cells by maintaining a repressive chromatin state of the Foxp3 promoter. PIAS1 acts by binding to the Foxp3 promoter to recruit DNA methyltransferases and heterochromatin protein 1 for epigenetic modifications. Pias1 deletion caused promoter demethylation, reduced histone H3 methylation at Lys(9), and enhanced promoter accessibility. Consistently, Pias1(-/-) mice displayed an increased natural T(reg) cell population and were resistant to the development of experimental autoimmune encephalomyelitis. Our studies have identified an epigenetic mechanism that negatively regulates the differentiation of natural T(reg) cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043201/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043201/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Bin -- Tahk, Samuel -- Yee, Kathleen M -- Fan, Guoping -- Shuai, Ke -- K01 AR52717-01/AR/NIAMS NIH HHS/ -- R01 AI063286/AI/NIAID NIH HHS/ -- R01 AI063286-05/AI/NIAID NIH HHS/ -- R01 GM085797/GM/NIGMS NIH HHS/ -- R01 GM085797-03/GM/NIGMS NIH HHS/ -- R01AI063286/AI/NIAID NIH HHS/ -- R01GM085797/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Oct 22;330(6003):521-5. doi: 10.1126/science.1193787.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematology-Oncology, Department of Medicine, 11-934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA. bliu@ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20966256" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; CD4-Positive T-Lymphocytes/cytology ; Chromatin/metabolism ; DNA (Cytosine-5-)-Methyltransferase/metabolism ; DNA Methylation ; Encephalomyelitis, Autoimmune, Experimental/immunology ; *Epigenesis, Genetic ; Female ; Forkhead Transcription Factors/genetics ; Histones/metabolism ; Lymphopoiesis/*genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Promoter Regions, Genetic ; Protein Inhibitors of Activated STAT/*physiology ; Repressor Proteins/*physiology ; T-Lymphocytes, Regulatory/*cytology/immunology ; Ubiquitin-Protein Ligases/*physiology
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    Cell biology. The case for RNA (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Chang C -- Arkin, Adam P -- New York, N.Y. -- Science. 2010 Nov 26;330(6008):1185-6. doi: 10.1126/science.1199495.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bioengineering, University of California, Berkeley, CA 94720, USA. ccliu@berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21109657" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Apoptosis ; Aptamers, Nucleotide/chemistry/genetics/*metabolism ; Artificial Gene Fusion ; Biotechnology ; Ganciclovir/pharmacology ; *Gene Expression Regulation ; *Genetic Engineering ; Humans ; Introns ; NF-kappa B/genetics/metabolism ; Nucleic Acid Conformation ; Protein Biosynthesis ; RNA/chemistry/genetics/*metabolism ; Signal Transduction ; beta Catenin/genetics/metabolism
    Print ISSN: 0036-8075
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    Biomedical research. Dream team plans a blitz on schizophrenia (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Jul 9;329(5988):130. doi: 10.1126/science.329.5988.130.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20616242" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; Baltimore ; *Biomedical Research ; *Brain/growth & development/physiology ; Budgets ; Financial Support ; Fund Raising ; Humans ; *Mental Disorders ; National Institutes of Health (U.S.) ; Research Personnel ; *Schizophrenia/drug therapy ; United States ; Universities
    Print ISSN: 0036-8075
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    National Institutes of Health. Lowering the boom on financial conflicts (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 May 28;328(5982):1091. doi: 10.1126/science.328.5982.1091.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20508102" target="_blank"〉PubMed〈/a〉
    Keywords: *Conflict of Interest ; *Disclosure ; Financing, Government ; Government Regulation ; Humans ; Income ; *National Institutes of Health (U.S.) ; Research Personnel/*economics/ethics/legislation & jurisprudence ; Research Support as Topic ; United States
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    Graduate education: the future is now (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russel, William B -- Ortega, Suzanne -- New York, N.Y. -- Science. 2010 Jul 30;329(5991):511. doi: 10.1126/science.329.5991.511-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20671168" target="_blank"〉PubMed〈/a〉
    Keywords: *Education, Graduate ; Federal Government ; Financing, Government ; *Training Support ; United States
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    The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-04
    Description: Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body. Tumor cells take up much more glucose and mainly process it through aerobic glycolysis, producing large quantities of secreted lactate with a lower use of oxidative phosphorylation that would generate more adenosine triphosphate (ATP), water, and carbon dioxide. This is the Warburg effect, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use. This metabolic switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways. Blocking these metabolic pathways or restoring these altered pathways could lead to a new approach in cancer treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Arnold J -- Puzio-Kuter, Anna M -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1340-4. doi: 10.1126/science.1193494.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Advanced Study, Princeton, NJ 08540, USA. alevine@ias.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21127244" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Cell Division ; Citric Acid Cycle ; Gene Expression Regulation, Neoplastic ; *Genes, Tumor Suppressor ; Glucose/metabolism ; Glutamine/metabolism ; Glycolysis ; Humans ; NADP/metabolism ; Neoplasms/drug therapy/*genetics/*metabolism/pathology ; *Oncogenes ; Pentose Phosphate Pathway ; Signal Transduction
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    Covering a broad dynamic range: information processing at the erythropoietin receptor (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-22
    Description: Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input; this process is carried out over a broad range of ligand concentrations. This relation depends solely on EpoR turnover independent of ligand binding, which suggests an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, Verena -- Schilling, Marcel -- Bachmann, Julie -- Baumann, Ute -- Raue, Andreas -- Maiwald, Thomas -- Timmer, Jens -- Klingmuller, Ursula -- New York, N.Y. -- Science. 2010 Jun 11;328(5984):1404-8. doi: 10.1126/science.1184913. Epub 2010 May 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20488988" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/*metabolism ; Computer Simulation ; Endocytosis ; Epoetin Alfa ; Erythropoietin/metabolism/pharmacology ; Kinetics ; Ligands ; Mice ; Models, Biological ; Protein Binding ; Receptors, Erythropoietin/*metabolism ; Recombinant Proteins ; Signal Transduction
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    Biomedical research. Peering over a cliff at the poststimulus world (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 May 7;328(5979):676. doi: 10.1126/science.328.5979.676.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20448157" target="_blank"〉PubMed〈/a〉
    Keywords: *American Recovery and Reinvestment Act ; Biomedical Research/*economics ; Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic ; United States
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    Psychology. A WEIRD view of human nature skews psychologists' studies (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Dan -- New York, N.Y. -- Science. 2010 Jun 25;328(5986):1627. doi: 10.1126/science.328.5986.1627.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20576866" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavior ; Cross-Cultural Comparison ; *Culture ; *Developed Countries ; *Human Characteristics ; Humans ; Internationality ; Publishing ; Research Design ; *Research Subjects ; *Students ; United States
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    Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-23
    Description: At the core of the mammalian circadian clock is a negative feedback loop in which the dimeric transcription factor CLOCK-BMAL1 drives processes that in turn suppress its transcriptional activity. To gain insight into the mechanisms of circadian feedback, we analyzed mouse protein complexes containing BMAL1. Receptor for activated C kinase-1 (RACK1) and protein kinase C-alpha (PKCalpha) were recruited in a circadian manner into a nuclear BMAL1 complex during the negative feedback phase of the cycle. Overexpression of RACK1 and PKCalpha suppressed CLOCK-BMAL1 transcriptional activity, and RACK1 stimulated phosphorylation of BMAL1 by PKCalpha in vitro. Depletion of endogenous RACK1 or PKCalpha from fibroblasts shortened the circadian period, demonstrating that both molecules function in the clock oscillatory mechanism. Thus, the classical PKC signaling pathway is not limited to relaying external stimuli but is rhythmically activated by internal processes, forming an integral part of the circadian feedback loop.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robles, Maria S -- Boyault, Cyril -- Knutti, Darko -- Padmanabhan, Kiran -- Weitz, Charles J -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):463-6. doi: 10.1126/science.1180067.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20093473" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors/metabolism ; Animals ; CLOCK Proteins/metabolism ; Cell Nucleus/metabolism ; Circadian Rhythm/*physiology ; Feedback, Physiological ; Fibroblasts/metabolism/physiology ; Mice ; Mice, Inbred C57BL ; Neuropeptides/genetics/*metabolism ; Phosphorylation ; Protein Binding ; Protein Kinase C-alpha/*metabolism ; RNA Interference ; Signal Transduction ; Transcription, Genetic
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    FDA regulations for drug development (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Behrman, Rachel E -- Woodcock, Janet -- New York, N.Y. -- Science. 2010 Jul 2;329(5987):33; author reply 33. doi: 10.1126/science.329.5987.33-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20595600" target="_blank"〉PubMed〈/a〉
    Keywords: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; *Drug Approval ; *Government Regulation ; Humans ; Neoplasms/*drug therapy ; United States ; *United States Food and Drug Administration
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    Research funding. Health bill backs evidence-based medicine, new drug studies (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Mar 26;327(5973):1562. doi: 10.1126/science.327.5973.1562.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20339036" target="_blank"〉PubMed〈/a〉
    Keywords: Comparative Effectiveness Research/*legislation & jurisprudence ; Drug Discovery/*legislation & jurisprudence ; Evidence-Based Medicine/*legislation & jurisprudence ; Financing, Government ; Health Care Reform/*legislation & jurisprudence ; Humans ; National Institutes of Health (U.S.)/economics/*legislation & ; jurisprudence/organization & administration ; Outcome Assessment (Health Care)/legislation & jurisprudence ; Research Support as Topic ; United States
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    Rewiring of genetic networks in response to DNA damage (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-04
    Description: Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They are very effective at identifying DNA repair pathways, highlighting new damage-dependent roles for the Slt2 kinase, Pph3 phosphatase, and histone variant Htz1. The data also reveal that protein complexes are generally stable in response to perturbation, but the functional relations between these complexes are substantially reorganized. Differential networks chart a new type of genetic landscape that is invaluable for mapping cellular responses to stimuli.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006187/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006187/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bandyopadhyay, Sourav -- Mehta, Monika -- Kuo, Dwight -- Sung, Min-Kyung -- Chuang, Ryan -- Jaehnig, Eric J -- Bodenmiller, Bernd -- Licon, Katherine -- Copeland, Wilbert -- Shales, Michael -- Fiedler, Dorothea -- Dutkowski, Janusz -- Guenole, Aude -- van Attikum, Haico -- Shokat, Kevan M -- Kolodner, Richard D -- Huh, Won-Ki -- Aebersold, Ruedi -- Keogh, Michael-Christopher -- Krogan, Nevan J -- Ideker, Trey -- P30CA013330/CA/NCI NIH HHS/ -- P50 GM081879/GM/NIGMS NIH HHS/ -- R01 ES014811/ES/NIEHS NIH HHS/ -- R01 ES014811-01A1/ES/NIEHS NIH HHS/ -- R01 ES014811-02/ES/NIEHS NIH HHS/ -- R01 ES014811-02S1/ES/NIEHS NIH HHS/ -- R01 ES014811-03/ES/NIEHS NIH HHS/ -- R01 ES014811-04/ES/NIEHS NIH HHS/ -- R01 ES014811-05/ES/NIEHS NIH HHS/ -- R01 ES014811-05S1/ES/NIEHS NIH HHS/ -- R01 ES014811-06/ES/NIEHS NIH HHS/ -- R01 GM026017/GM/NIGMS NIH HHS/ -- R01 GM084279/GM/NIGMS NIH HHS/ -- R01 GM084279-01A1/GM/NIGMS NIH HHS/ -- R01 GM084279-02/GM/NIGMS NIH HHS/ -- R01 GM084279-02S1/GM/NIGMS NIH HHS/ -- R01 GM084279-03/GM/NIGMS NIH HHS/ -- R01 GM084279-04/GM/NIGMS NIH HHS/ -- R01 GM084448/GM/NIGMS NIH HHS/ -- R01-ES14811/ES/NIEHS NIH HHS/ -- R01-GM084279/GM/NIGMS NIH HHS/ -- R37 GM026017/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1385-9. doi: 10.1126/science.1195618.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21127252" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatin/metabolism ; *DNA Damage ; DNA Repair/*genetics ; DNA, Fungal/genetics ; *Epistasis, Genetic ; *Gene Regulatory Networks ; Genes, Fungal ; Histones/genetics/metabolism ; Methyl Methanesulfonate/pharmacology ; Mitogen-Activated Protein Kinases/genetics/metabolism ; Mutagens/pharmacology ; Mutation ; Phosphoprotein Phosphatases/genetics/metabolism ; Protein Interaction Mapping ; Protein-Serine-Threonine Kinases/genetics/metabolism ; Saccharomyces cerevisiae/*genetics/*metabolism ; Saccharomyces cerevisiae Proteins/genetics/*metabolism ; Signal Transduction ; Transcription Factors/genetics/metabolism
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    Cell signaling. Signaling through cooperation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, Emmanuel D -- Landry, Christian R -- Michnick, Stephen W -- New York, N.Y. -- Science. 2010 May 21;328(5981):983-4. doi: 10.1126/science.1190993.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Biochimie, Universite de Montreal, Montreal, Quebec, Canada H3T 1J4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20489011" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Mass Spectrometry ; Metabolic Networks and Pathways ; Models, Biological ; Phosphoprotein Phosphatases/*metabolism ; Phosphorylation ; Protein Interaction Mapping ; Protein Kinases/*metabolism ; Saccharomyces cerevisiae/enzymology/*metabolism ; Saccharomyces cerevisiae Proteins/*metabolism ; *Signal Transduction
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    Publishing. White House mulls plan to broaden access to published papers (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):259. doi: 10.1126/science.327.5963.259-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075225" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Costs and Cost Analysis ; *Financing, Government ; National Institutes of Health (U.S.) ; Periodicals as Topic/economics ; *Publishing/economics ; *Research Support as Topic ; United States
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    Cell biology. Septins at the nexus (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barral, Yves -- New York, N.Y. -- Science. 2010 Sep 10;329(5997):1289-90. doi: 10.1126/science.1195445.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland. yves.barral@bc.biol.ethz.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829470" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/metabolism/ultrastructure ; *Cell Polarity ; Centrioles/metabolism ; Cilia/*metabolism/ultrastructure ; Cytoskeletal Proteins/chemistry/*metabolism ; Diffusion ; GTP-Binding Proteins/chemistry/*metabolism ; Glycoproteins/genetics/metabolism ; Hedgehog Proteins/metabolism ; Humans ; Mutant Proteins/metabolism ; Mutation ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Xenopus Proteins/metabolism
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    Restriction of receptor movement alters cellular response: physical force sensing by EphA2 (2010)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2010-03-13
    Description: Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on apposed cell surfaces plays important roles in development and exhibits poorly understood functional alterations in cancer. We reconstituted this intermembrane signaling geometry between live EphA2-expressing human breast cancer cells and supported membranes displaying laterally mobile ephrin-A1. Receptor-ligand binding, clustering, and subsequent lateral transport within this junction were observed. EphA2 transport can be blocked by physical barriers nanofabricated onto the underlying substrate. This physical reorganization of EphA2 alters the cellular response to ephrin-A1, as observed by changes in cytoskeleton morphology and recruitment of a disintegrin and metalloprotease 10. Quantitative analysis of receptor-ligand spatial organization across a library of 26 mammary epithelial cell lines reveals characteristic differences that strongly correlate with invasion potential. These observations reveal a mechanism for spatio-mechanical regulation of EphA2 signaling pathways.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895569/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895569/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salaita, Khalid -- Nair, Pradeep M -- Petit, Rebecca S -- Neve, Richard M -- Das, Debopriya -- Gray, Joe W -- Groves, Jay T -- P50 CA 58207/CA/NCI NIH HHS/ -- P50 CA058207/CA/NCI NIH HHS/ -- P50 CA058207-060002/CA/NCI NIH HHS/ -- P50 CA058207-08/CA/NCI NIH HHS/ -- P50 CA058207-09/CA/NCI NIH HHS/ -- U54 CA 112970/CA/NCI NIH HHS/ -- U54 CA112970/CA/NCI NIH HHS/ -- U54 CA112970-01/CA/NCI NIH HHS/ -- U54 CA143836/CA/NCI NIH HHS/ -- U54 CA143836-01/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Mar 12;327(5971):1380-5. doi: 10.1126/science.1181729.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Chemistry, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20223987" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins/metabolism ; Actomyosin/physiology ; Amyloid Precursor Protein Secretases/metabolism ; Antigens, CD44/metabolism ; Breast Neoplasms/*metabolism/pathology ; Cell Line, Tumor ; Cell Membrane/metabolism ; Cell Shape ; Cytoskeleton/physiology/ultrastructure ; Ephrin-A1/*chemistry/*metabolism ; Female ; Humans ; Ligands ; Lipid Bilayers ; *Mechanotransduction, Cellular ; Membrane Proteins/metabolism ; Neoplasm Invasiveness ; Protein Binding ; Protein Multimerization ; Protein Transport ; Receptor, EphA2/*chemistry/*metabolism ; Signal Transduction
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    Structural basis for activation of class Ib ribonucleotide reductase (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-07
    Description: The class Ib ribonucleotide reductase of Escherichia coli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)2-tyrosyl radical (Y*) or a Fe(III)2-Y* cofactor in the NrdF subunit. Whereas Fe(III)2-Y* can self-assemble from Fe(II)2-NrdF and O2, activation of Mn(II)2-NrdF requires a reduced flavoprotein, NrdI, proposed to form the oxidant for cofactor assembly by reduction of O2. The crystal structures reported here of E. coli Mn(II)2-NrdF and Fe(II)2-NrdF reveal different coordination environments, suggesting distinct initial binding sites for the oxidants during cofactor activation. In the structures of Mn(II)2-NrdF in complex with reduced and oxidized NrdI, a continuous channel connects the NrdI flavin cofactor to the NrdF Mn(II)2 active site. Crystallographic detection of a putative peroxide in this channel supports the proposed mechanism of Mn(III)2-Y* cofactor assembly.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020666/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020666/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boal, Amie K -- Cotruvo, Joseph A Jr -- Stubbe, JoAnne -- Rosenzweig, Amy C -- GM58518/GM/NIGMS NIH HHS/ -- GM81393/GM/NIGMS NIH HHS/ -- R01 GM058518/GM/NIGMS NIH HHS/ -- R01 GM058518-13/GM/NIGMS NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 17;329(5998):1526-30. doi: 10.1126/science.1190187. Epub 2010 Aug 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20688982" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Catalytic Domain ; Coenzymes/chemistry/metabolism ; Crystallography, X-Ray ; Enzyme Activation ; Escherichia coli/*enzymology ; Escherichia coli Proteins/*chemistry/*metabolism ; Ferrous Compounds/chemistry/metabolism ; Flavin Mononucleotide/chemistry/metabolism ; Flavodoxin/*chemistry/metabolism ; Hydrogen Bonding ; Ligands ; Manganese/*chemistry/metabolism ; Models, Molecular ; Oxidants/chemistry/metabolism ; Oxidation-Reduction ; Oxygen/chemistry/metabolism ; Peroxides/chemistry/metabolism ; Protein Folding ; Protein Multimerization ; Protein Subunits/chemistry/metabolism ; Ribonucleotide Reductases/*chemistry/*metabolism
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    Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-14
    Description: Dendritic cells (DCs) play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens. However, the intracellular signaling networks that program DCs to become tolerogenic remain unknown. We report here that the Wnt-beta-catenin signaling in intestinal dendritic cells regulates the balance between inflammatory versus regulatory responses in the gut. beta-catenin in intestinal dendritic cells was required for the expression of anti-inflammatory mediators such as retinoic acid-metabolizing enzymes, interleukin-10, and transforming growth factor-beta, and the stimulation of regulatory T cell induction while suppressing inflammatory effector T cells. Furthermore, ablation of beta-catenin expression in DCs enhanced inflammatory responses and disease in a mouse model of inflammatory bowel disease. Thus, beta-catenin signaling programs DCs to a tolerogenic state, limiting the inflammatory response.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732486/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732486/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manicassamy, Santhakumar -- Reizis, Boris -- Ravindran, Rajesh -- Nakaya, Helder -- Salazar-Gonzalez, Rosa Maria -- Wang, Yi-Chong -- Pulendran, Bali -- HHSN266 200700006C/PHS HHS/ -- N01 AI50019/AI/NIAID NIH HHS/ -- N01 AI50025/AI/NIAID NIH HHS/ -- R01 AI048638/AI/NIAID NIH HHS/ -- R01 AI056499/AI/NIAID NIH HHS/ -- R01 DK057665/DK/NIDDK NIH HHS/ -- R01DK057665,/DK/NIDDK NIH HHS/ -- R37 AI048638/AI/NIAID NIH HHS/ -- R37 DK057665/DK/NIDDK NIH HHS/ -- R37AI48638,/AI/NIAID NIH HHS/ -- U19 AI057266/AI/NIAID NIH HHS/ -- U19AI057266,/AI/NIAID NIH HHS/ -- U54 AI057157/AI/NIAID NIH HHS/ -- U54AI057157/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 Aug 13;329(5993):849-53. doi: 10.1126/science.1188510.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emory Vaccine Center, and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20705860" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytokines/metabolism ; Dendritic Cells/*immunology/metabolism ; Gene Expression Profiling ; *Inflammation ; Inflammatory Bowel Diseases/*immunology ; Intestinal Mucosa/cytology/*immunology/metabolism ; Macrophages/immunology/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; *Self Tolerance ; Signal Transduction ; T-Lymphocytes, Helper-Inducer/cytology/*immunology ; T-Lymphocytes, Regulatory/*immunology ; Tretinoin/metabolism ; Wnt Proteins/metabolism ; beta Catenin/*metabolism
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    Research funding. Politics and parthenotes (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tingen, C -- Rodriguez, S -- Campo-Engelstein, L -- Woodruff, T K -- New York, N.Y. -- Science. 2010 Oct 22;330(6003):453. doi: 10.1126/science.1196881.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20966235" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryo Research/*legislation & jurisprudence ; *Embryonic Stem Cells ; Female ; Financing, Government/legislation & jurisprudence ; Humans ; Mice ; Ovum/physiology ; *Parthenogenesis ; Research Support as Topic/*legislation & jurisprudence ; United States
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    Intellectual property. Turning patent swords into shares (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Overwalle, Geertrui -- New York, N.Y. -- Science. 2010 Dec 17;330(6011):1630-1. doi: 10.1126/science.1189592.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Intellectual Property Rights, University of Leuven, 3000 Leuven, Belgium. geertrui.vanoverwalle@law.kuleuven.be〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21164001" target="_blank"〉PubMed〈/a〉
    Keywords: Europe ; *Genes ; Genetic Testing/*legislation & jurisprudence ; Humans ; *Patents as Topic ; United States
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    Improving access to research (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Courant, Paul N -- O'Donnell, James J -- Okerson, Ann -- Taylor, Crispin B -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):393. doi: 10.1126/science.1186933.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20093440" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Financing, Government ; Policy Making ; Publishing ; *Research ; *Research Support as Topic ; United States
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    Cuban health care: benefits without costs (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bodenstein, Lawrence -- New York, N.Y. -- Science. 2010 Aug 6;329(5992):628; author reply 628. doi: 10.1126/science.329.5992.628-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20689002" target="_blank"〉PubMed〈/a〉
    Keywords: Cuba ; *Health Care Costs ; Humans ; National Health Programs/*economics ; United States
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    Noise can induce bimodality in positive transcriptional feedback loops without bistability (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-02-27
    Description: Transcriptional positive-feedback loops are widely associated with bistability, characterized by two stable expression states that allow cells to respond to analog signals in a digital manner. Using a synthetic system in budding yeast, we show that positive feedback involving a promoter with multiple transcription factor (TF) binding sites can induce a steady-state bimodal response without cooperative binding of the TF. Deterministic models of this system do not predict bistability. Rather, the bimodal response requires a short-lived TF and stochastic fluctuations in the TF's expression. Multiple binding sites provide these fluctuations. Because many promoters possess multiple binding sites and many TFs are unstable, positive-feedback loops in gene regulatory networks may exhibit bimodal responses, but not necessarily because of deterministic bistability, as is commonly thought.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉To, Tsz-Leung -- Maheshri, Narendra -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1142-5. doi: 10.1126/science.1178962.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20185727" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Binding Sites ; Cell Nucleus/metabolism ; Doxycycline/metabolism ; Feedback, Physiological ; *Gene Expression Regulation, Fungal ; *Gene Regulatory Networks ; Models, Genetic ; Models, Statistical ; Promoter Regions, Genetic ; Protein Stability ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/*genetics/metabolism ; Saccharomyces cerevisiae Proteins/chemistry/genetics/metabolism ; Stochastic Processes ; Transcription Factors/chemistry/genetics/*metabolism ; *Transcription, Genetic
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    Variation in transcription factor binding among humans (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-20
    Description: Differences in gene expression may play a major role in speciation and phenotypic diversity. We examined genome-wide differences in transcription factor (TF) binding in several humans and a single chimpanzee by using chromatin immunoprecipitation followed by sequencing. The binding sites of RNA polymerase II (PolII) and a key regulator of immune responses, nuclear factor kappaB (p65), were mapped in 10 lymphoblastoid cell lines, and 25 and 7.5% of the respective binding regions were found to differ between individuals. Binding differences were frequently associated with single-nucleotide polymorphisms and genomic structural variants, and these differences were often correlated with differences in gene expression, suggesting functional consequences of binding variation. Furthermore, comparing PolII binding between humans and chimpanzee suggests extensive divergence in TF binding. Our results indicate that many differences in individuals and species occur at the level of TF binding, and they provide insight into the genetic events responsible for these differences.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938768/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938768/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasowski, Maya -- Grubert, Fabian -- Heffelfinger, Christopher -- Hariharan, Manoj -- Asabere, Akwasi -- Waszak, Sebastian M -- Habegger, Lukas -- Rozowsky, Joel -- Shi, Minyi -- Urban, Alexander E -- Hong, Mi-Young -- Karczewski, Konrad J -- Huber, Wolfgang -- Weissman, Sherman M -- Gerstein, Mark B -- Korbel, Jan O -- Snyder, Michael -- R01 CA077808/CA/NCI NIH HHS/ -- R01 CA077808-09/CA/NCI NIH HHS/ -- T32 GM007205/GM/NIGMS NIH HHS/ -- T32 GM007205-34/GM/NIGMS NIH HHS/ -- T32GM07205/GM/NIGMS NIH HHS/ -- U54 HG004558/HG/NHGRI NIH HHS/ -- U54 HG004558-04/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Apr 9;328(5975):232-5. doi: 10.1126/science.1183621. Epub 2010 Mar 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20299548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Cell Line ; Chromatin Immunoprecipitation ; DNA Copy Number Variations ; DNA, Intergenic ; Female ; *Gene Expression Regulation ; Humans ; Male ; Pan troglodytes/genetics ; *Polymorphism, Single Nucleotide ; Protein Binding ; RNA Polymerase II/genetics/*metabolism ; Sequence Analysis, DNA ; Species Specificity ; Transcription Factor RelA/genetics/*metabolism ; Transcription Initiation Site
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    Patents: a threat to innovation? (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manocaran, Merlina -- New York, N.Y. -- Science. 2010 Jan 1;327(5961):31-2; author reply 32. doi: 10.1126/science.327.5961.31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20044557" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Discovery ; Drug Industry/economics/*legislation & jurisprudence ; Drugs, Generic ; *Legislation, Drug ; Patents as Topic/*legislation & jurisprudence ; *Pharmaceutical Preparations ; United States
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    Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-08
    Description: Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vegiopoulos, Alexandros -- Muller-Decker, Karin -- Strzoda, Daniela -- Schmitt, Iris -- Chichelnitskiy, Evgeny -- Ostertag, Anke -- Berriel Diaz, Mauricio -- Rozman, Jan -- Hrabe de Angelis, Martin -- Nusing, Rolf M -- Meyer, Carola W -- Wahli, Walter -- Klingenspor, Martin -- Herzig, Stephan -- New York, N.Y. -- Science. 2010 May 28;328(5982):1158-61. doi: 10.1126/science.1186034. Epub 2010 May 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20448152" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes, Brown/cytology/*physiology ; Adipogenesis ; Adipose Tissue ; Adipose Tissue, Brown/cytology/*physiology ; Adipose Tissue, White/enzymology/*physiology ; Adrenergic beta-3 Receptor Agonists ; Adrenergic beta-Agonists/pharmacology ; Animals ; Body Weight ; Cyclooxygenase 2/*genetics/*metabolism ; Dietary Fats/administration & dosage ; Dioxoles/pharmacology ; *Energy Metabolism ; Female ; Gene Expression Regulation, Enzymologic ; Homeostasis ; Male ; Mesenchymal Stromal Cells/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mice, Transgenic ; Norepinephrine/metabolism ; Obesity/etiology/prevention & control ; Oxygen Consumption ; Prostaglandins/*metabolism ; Receptors, Adrenergic, beta-3/metabolism ; Signal Transduction ; *Thermogenesis
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    G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-16
    Description: Integrins mediate cell adhesion to the extracellular matrix and transmit signals within the cell that stimulate cell spreading, retraction, migration, and proliferation. The mechanism of integrin outside-in signaling has been unclear. We found that the heterotrimeric guanine nucleotide-binding protein (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-integrin interaction was promoted by ligand binding to the integrin alphaIIbbeta3 and by guanosine triphosphate (GTP) loading of Galpha13. Interference of Galpha13 expression or a myristoylated fragment of Galpha13 that inhibited interaction of alphaIIbbeta3 with Galpha13 diminished activation of protein kinase c-Src and stimulated the small guanosine triphosphatase RhoA, consequently inhibiting cell spreading and accelerating cell retraction. We conclude that integrins are noncanonical Galpha13-coupled receptors that provide a mechanism for dynamic regulation of RhoA.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842917/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842917/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, Haixia -- Shen, Bo -- Flevaris, Panagiotis -- Chow, Christina -- Lam, Stephen C-T -- Voyno-Yasenetskaya, Tatyana A -- Kozasa, Tohru -- Du, Xiaoping -- GM061454/GM/NIGMS NIH HHS/ -- GM074001/GM/NIGMS NIH HHS/ -- HL062350/HL/NHLBI NIH HHS/ -- HL068819/HL/NHLBI NIH HHS/ -- HL080264/HL/NHLBI NIH HHS/ -- R01 GM061454/GM/NIGMS NIH HHS/ -- R01 GM061454-09/GM/NIGMS NIH HHS/ -- R01 GM074001/GM/NIGMS NIH HHS/ -- R01 GM074001-02/GM/NIGMS NIH HHS/ -- R01 HL062350/HL/NHLBI NIH HHS/ -- R01 HL062350-09/HL/NHLBI NIH HHS/ -- R01 HL068819/HL/NHLBI NIH HHS/ -- R01 HL068819-08/HL/NHLBI NIH HHS/ -- R01 HL080264/HL/NHLBI NIH HHS/ -- R01 HL080264-04/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):340-3. doi: 10.1126/science.1174779.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, Room E403, Chicago, IL 60612, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075254" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Blood Platelets/*physiology ; Clot Retraction ; Fibrinogen/metabolism ; GTP-Binding Protein alpha Subunits, G12-G13/genetics/*metabolism ; Humans ; Integrin beta3/*metabolism ; Ligands ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Platelet Adhesiveness ; Platelet Glycoprotein GPIIb-IIIa Complex/*metabolism ; Protein Binding ; Protein Structure, Tertiary ; Proto-Oncogene Proteins pp60(c-src)/metabolism ; RNA, Small Interfering ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; rhoA GTP-Binding Protein/antagonists & inhibitors/metabolism
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    Cell biology. Burn out or fade away? (2010)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2010-03-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Topisirovic, Ivan -- Sonenberg, Nahum -- New York, N.Y. -- Science. 2010 Mar 5;327(5970):1210-1. doi: 10.1126/science.1187497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, McGill University, Montreal, Quebec, H3A 1A3, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20203039" target="_blank"〉PubMed〈/a〉
    Keywords: AMP-Activated Protein Kinases/metabolism ; *Aging ; Animals ; Autophagy ; Caloric Restriction ; Drosophila Proteins/*genetics/metabolism/*physiology ; Drosophila melanogaster/genetics/metabolism/*physiology ; Feedback, Physiological ; Heat-Shock Proteins/*genetics/*physiology ; Metabolic Networks and Pathways ; Mitochondria/metabolism ; Models, Animal ; Oxidation-Reduction ; Oxidative Stress ; Protein Biosynthesis ; Protein Kinases/*metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases
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    Iraq War. Leaked documents provide bonanza for researchers (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):575. doi: 10.1126/science.330.6004.575.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030619" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; *Iraq War, 2003-2011 ; Military Personnel/*statistics & numerical data ; *Mortality ; United States ; Violence/*statistics & numerical data
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    Patent policy. Amicus brief unfriendly to gene patents (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):746-7. doi: 10.1126/science.330.6005.746-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051606" target="_blank"〉PubMed〈/a〉
    Keywords: *Dna ; *Genes ; Humans ; *Patents as Topic ; Policy ; United States
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    Biosecurity. New biosecurity rules to target the riskiest pathogens (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2010 Jul 16;329(5989):264-5. doi: 10.1126/science.329.5989.264-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20647433" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare Agents/*legislation & jurisprudence ; *Bioterrorism/legislation & jurisprudence/prevention & control ; *Containment of Biohazards/standards ; *Government Regulation ; Humans ; *Research Personnel ; *Security Measures/legislation & jurisprudence/standards ; United States ; United States Department of Agriculture/legislation & jurisprudence ; United States Dept. of Health and Human Services/legislation & jurisprudence
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Patents. Cancer gene patents ruled invalid (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2010 Apr 9;328(5975):153. doi: 10.1126/science.328.5975.153.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20378781" target="_blank"〉PubMed〈/a〉
    Keywords: Genes ; *Genes, BRCA1 ; *Genes, BRCA2 ; Humans ; New York ; Patents as Topic/*legislation & jurisprudence ; United States
    Print ISSN: 0036-8075
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    Changing face of microglia (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-06
    Description: Microglia are resident brain cells that sense pathological tissue alterations. They can develop into brain macrophages and perform immunological functions. However, expression of immune proteins by microglia is not synonymous with inflammation, because these molecules can have central nervous system (CNS)-specific roles. Through their involvement in pain mechanisms, microglia also respond to external threats. Experimental studies support the idea that microglia have a role in the maintenance of synaptic integrity. Analogous to electricians, they are capable of removing defunct axon terminals, thereby helping neuronal connections to stay intact. Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Graeber, Manuel B -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):783-8. doi: 10.1126/science.1190929.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia. manuel@graeber.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051630" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior ; Behavior, Animal ; Bone Marrow Transplantation ; Brain/*cytology/pathology/physiology ; Brain Diseases/pathology/physiopathology/therapy ; Humans ; Macrophages/cytology/physiology ; Mental Disorders/physiopathology ; Microglia/immunology/*physiology ; Mutation ; Neuralgia/physiopathology ; Neurodegenerative Diseases/pathology/physiopathology/therapy ; Signal Transduction ; Spinal Cord/*cytology/pathology/physiology ; Synapses/physiology
    Print ISSN: 0036-8075
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    Science and native rights. In search of Sitting Bull (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Travis, John -- New York, N.Y. -- Science. 2010 Oct 8;330(6001):172-3. doi: 10.1126/science.330.6001.172-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929754" target="_blank"〉PubMed〈/a〉
    Keywords: *Burial ; DNA/*analysis ; *Famous Persons ; Hair/*chemistry ; History, 19th Century ; Humans ; Indians, North American/*genetics/history ; Male ; Polymorphism, Single Nucleotide ; United States
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    Can the census go digital? (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kean, Sam -- New York, N.Y. -- Science. 2010 Oct 15;330(6002):310-2. doi: 10.1126/science.330.6002.310.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20947739" target="_blank"〉PubMed〈/a〉
    Keywords: *Censuses ; *Databases, Factual ; Humans ; Privacy ; United States
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    Gulf oil spill. After outcry, oil data inches into the open (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schenkman, Lauren -- New York, N.Y. -- Science. 2010 Aug 20;329(5994):888-9. doi: 10.1126/science.329.5994.888-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20724606" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; Atlantic Ocean ; *Consultants ; Contracts ; *Environment ; Information Dissemination ; *Petroleum ; *Publishing ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Ethics. DNA returned to tribe, raising questions about consent (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Apr 30;328(5978):558. doi: 10.1126/science.328.5978.558.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20430983" target="_blank"〉PubMed〈/a〉
    Keywords: Arizona ; Blood Specimen Collection ; *Dna ; Databases, Genetic ; Genetic Research/*ethics ; Humans ; Indians, North American/*genetics ; *Informed Consent ; National Library of Medicine (U.S.) ; United States ; Universities/*ethics/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Science and religion. Latest prize bolsters Templeton's shift to mainstream (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2010 Mar 26;327(5973):1565. doi: 10.1126/science.327.5973.1565.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20339038" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Foundations/economics ; *Religion and Science ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Drug safety. Planned study of Avandia in doubt after FDA review (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kean, Sam -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):375. doi: 10.1126/science.329.5990.375.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20651123" target="_blank"〉PubMed〈/a〉
    Keywords: Cardiovascular Diseases/chemically induced ; Diabetes Mellitus/*drug therapy ; Humans ; Hypoglycemic Agents/adverse effects/*therapeutic use ; Informed Consent ; Patient Selection/ethics ; Randomized Controlled Trials as Topic ; Thiazolidinediones/adverse effects/*therapeutic use ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Gulf oil spill. Three historic blowouts (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schenkman, Lauren -- New York, N.Y. -- Science. 2010 May 7;328(5979):675. doi: 10.1126/science.328.5979.675.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20448156" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; *Environment ; North Sea ; Pacific Ocean ; *Petroleum ; United States ; *Water Pollutants, Chemical
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Disasters. Scenario-building for the Deepwater Horizon oil spill (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Machlis, Gary E -- McNutt, Marcia K -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1018-9. doi: 10.1126/science.1195382.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Strategic Sciences Working Group, U.S. Department of the Interior, Washington, DC 20024, USA. gary_machlis@nps.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798302" target="_blank"〉PubMed〈/a〉
    Keywords: *Accidents ; Animals ; Atlantic Ocean ; Decision Making ; *Disasters ; *Ecosystem ; Environmental Pollution ; Fisheries ; Forecasting ; Interdisciplinary Communication ; *Petroleum ; Planning Techniques ; Public Policy ; United States ; United States Government Agencies ; Wetlands
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    Newsmaker interview. Francis Collins: on recruiting Varmus, discovering drugs, the funding cliff. Interview by Jocelyn Kaiser (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis -- New York, N.Y. -- Science. 2010 May 28;328(5982):1090-1. doi: 10.1126/science.328.5982.1090.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20508101" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Drug Discovery ; Financing, Government ; Genome-Wide Association Study ; National Cancer Institute (U.S.)/organization & administration ; National Institutes of Health (U.S.)/economics/*organization & administration ; Research Support as Topic ; Translational Medical Research ; United States
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    Public health. U.S. panel favors wider use of preventive drug treatment (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):130-1. doi: 10.1126/science.327.5962.130.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056859" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; C-Reactive Protein/analysis ; Cardiovascular Diseases/*prevention & control ; Female ; Fluorobenzenes/adverse effects/*therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use ; Male ; Pyrimidines/adverse effects/*therapeutic use ; Randomized Controlled Trials as Topic ; Rosuvastatin Calcium ; Sulfonamides/adverse effects/*therapeutic use ; United States ; United States Food and Drug Administration
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    Let top students go forth and prosper (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Madhavan, Guruprasad -- Oakley, Barbara Ann -- New York, N.Y. -- Science. 2010 Jan 1;327(5961):32. doi: 10.1126/science.327.5961.32-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20044558" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Engineering/education ; Humans ; *Science/education ; Students ; United States
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    The onset of collective behavior in social amoebae (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-24
    Description: In the social amoebae Dictyostelium discoideum, periodic synthesis and release of extracellular cyclic adenosine 3',5'-monophosphate (cAMP) guide cell aggregation and commitment to form fruiting bodies. It is unclear whether these oscillations are an intrinsic property of individual cells or if they exist only as a population-level phenomenon. Here, we showed by live-cell imaging of intact cell populations that pulses originate from a discrete location despite constant exchange of cells to and from the region. In a perfusion chamber, both isolated single cells and cell populations switched from quiescence to rhythmic activity depending on the concentration of extracellular cAMP. A quantitative analysis showed that stochastic pulsing of individual cells below the threshold concentration of extracellular cAMP plays a critical role in the onset of collective behavior.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120019/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120019/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gregor, Thomas -- Fujimoto, Koichi -- Masaki, Noritaka -- Sawai, Satoshi -- P50 GM071508/GM/NIGMS NIH HHS/ -- P50 GM071508-08/GM/NIGMS NIH HHS/ -- R01 GM098407/GM/NIGMS NIH HHS/ -- R01 GM098407-01A1/GM/NIGMS NIH HHS/ -- R01 GM098407-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 May 21;328(5981):1021-5. doi: 10.1126/science.1183415. Epub 2010 Apr 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20413456" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Adenylyl Cyclases/metabolism ; Cell Aggregation ; Cell Count ; Cyclic AMP/*metabolism/pharmacology ; Cyclic AMP-Dependent Protein Kinases/genetics/metabolism ; Cytosol/metabolism ; Dictyostelium/cytology/genetics/growth & development/*physiology ; Fluorescence Resonance Energy Transfer ; Models, Biological ; Periodicity ; Protozoan Proteins/genetics/metabolism ; Quorum Sensing ; Signal Transduction ; Stochastic Processes
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    An oxidative enzyme boosting the enzymatic conversion of recalcitrant polysaccharides (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-12
    Description: Efficient enzymatic conversion of crystalline polysaccharides is crucial for an economically and environmentally sustainable bioeconomy but remains unfavorably inefficient. We describe an enzyme that acts on the surface of crystalline chitin, where it introduces chain breaks and generates oxidized chain ends, thus promoting further degradation by chitinases. This enzymatic activity was discovered and further characterized by using mass spectrometry and chromatographic separation methods to detect oxidized products generated in the absence or presence of H(2)(18)O or (18)O(2). There are strong indications that similar enzymes exist that work on cellulose. Our findings not only demonstrate the existence of a hitherto unknown enzyme activity but also provide new avenues toward more efficient enzymatic conversion of biomass.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaaje-Kolstad, Gustav -- Westereng, Bjorge -- Horn, Svein J -- Liu, Zhanliang -- Zhai, Hong -- Sorlie, Morten -- Eijsink, Vincent G H -- New York, N.Y. -- Science. 2010 Oct 8;330(6001):219-22. doi: 10.1126/science.1192231.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Post Office Box 5003, 1432 As, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929773" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/antagonists & inhibitors/chemistry/genetics/*metabolism ; Binding Sites ; Biocatalysis ; Biomass ; Carrier Proteins/antagonists & inhibitors/chemistry/genetics/*metabolism ; Cations, Divalent/metabolism/pharmacology ; Chitin/*metabolism ; Chitinase/*metabolism ; Chromatography, High Pressure Liquid ; Edetic Acid/pharmacology ; Enzyme Inhibitors/pharmacology ; Hydrolysis ; Isotope Labeling ; Oligosaccharides/metabolism ; Oxidation-Reduction ; Oxygen Isotopes/metabolism ; Serratia marcescens/*enzymology ; Solubility ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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    Air pollution. Taking the sting out of acid rain (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2010 Nov 12;330(6006):910-1. doi: 10.1126/science.330.6006.910.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21071645" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Rain/*legislation & jurisprudence ; Air Pollution/*legislation & jurisprudence ; Animals ; Biodiversity ; *Ecosystem ; Fishes ; *Fresh Water/chemistry/microbiology ; Hydrogen-Ion Concentration ; Sulfur ; United States
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    Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: Stem cells are maintained in the niche by intercellular interactions and signaling networks. In this work, we study extracellular signals required for maintenance of the root stem cell niche in higher plants. We identify a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. We name these peptides root meristem growth factors (RGFs). RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation in Arabidopsis. RGF1 defines expression levels and patterns of the stem cell transcription factor PLETHORA, mainly at the posttranscriptional level. The RGFs function independently of the auxin pathway. These peptide signals play a crucial role in postembryonic root development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuzaki, Yo -- Ogawa-Ohnishi, Mari -- Mori, Ayaka -- Matsubayashi, Yoshikatsu -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1065-7. doi: 10.1126/science.1191132.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798316" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/cytology/genetics/growth & development/*physiology ; Arabidopsis Proteins/genetics/*metabolism/secretion ; Cell Proliferation ; Gene Expression Regulation, Plant ; Genes, Plant ; Indoleacetic Acids/metabolism ; Meristem/cytology/growth & development/physiology ; Peptides/genetics/*metabolism/secretion ; Phenotype ; Plant Growth Regulators/genetics/*metabolism ; Plant Roots/*cytology/growth & development/physiology ; Plants, Genetically Modified ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Stem Cell Niche/*physiology ; Stem Cells/cytology/*physiology ; Sulfotransferases/genetics/metabolism ; Transcription Factors/genetics/metabolism ; Up-Regulation
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    Animal research. Dog dealers' days may be numbered (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, David -- New York, N.Y. -- Science. 2010 Feb 26;327(5969):1076-7. doi: 10.1126/science.327.5969.1076.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20185707" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/ethics/*legislation & jurisprudence ; Animal Welfare/*legislation & jurisprudence ; Animals ; *Cats ; Commerce/*legislation & jurisprudence ; *Dogs ; National Institutes of Health (U.S.) ; United States ; United States Department of Agriculture/legislation & jurisprudence
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Gulf oil spill. Government chided for poor planning and communication (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- Stokstad, Erik -- New York, N.Y. -- Science. 2010 Oct 15;330(6002):302-3. doi: 10.1126/science.330.6002.302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20947731" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; *Ecosystem ; *Environmental Pollution ; *Information Dissemination ; *Petroleum ; United States ; United States Government Agencies
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    A transient niche regulates the specification of Drosophila intestinal stem cells (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-01-09
    Description: Stem cell niches are locations where stem cells reside and self-renew. Although studies have shown how niches maintain stem cell fate during tissue homeostasis, less is known about their roles in establishing stem cells. The adult Drosophila midgut is maintained by intestinal stem cells (ISCs); however, how they are established is unknown. Here, we show that an ISC progenitor generates a niche cell via Notch signaling. This niche uses the bone morphogenetic protein 2/4 homolog, decapentaplegic, to allow progenitors to divide in an undifferentiated state and subsequently breaks down and dies, resulting in the specification of ISCs in the adult midgut. Our results demonstrate a paradigm for stem cell-niche biology, where progenitors generate transient niches that determine stem cell fate and may give insights into stem cell specification in other tissues.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857772/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857772/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathur, Divya -- Bost, Alyssa -- Driver, Ian -- Ohlstein, Benjamin -- R01 DK082456/DK/NIDDK NIH HHS/ -- R01 DK082456-01/DK/NIDDK NIH HHS/ -- T32 GM007088/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 8;327(5962):210-3. doi: 10.1126/science.1181958.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20056890" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*cytology/physiology ; Animals ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Drosophila/*cytology/growth & development/metabolism ; Drosophila Proteins/genetics/metabolism ; Enterocytes/cytology ; Epithelial Cells/*cytology ; Intestines/cytology/growth & development ; Larva/cytology/growth & development/metabolism ; Metamorphosis, Biological ; Organogenesis ; Receptors, Notch/metabolism ; Signal Transduction ; Stem Cell Niche/*physiology
    Print ISSN: 0036-8075
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    Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-27
    Description: Shelterin is an essential telomeric protein complex that prevents DNA damage signaling and DNA repair at mammalian chromosome ends. Here we report on the role of the TRF2-interacting factor Rap1, a conserved shelterin subunit of unknown function. We removed Rap1 from mouse telomeres either through gene deletion or by replacing TRF2 with a mutant that does not bind Rap1. Rap1 was dispensable for the essential functions of TRF2--repression of ATM kinase signaling and nonhomologous end joining (NHEJ)--and mice lacking telomeric Rap1 were viable and fertile. However, Rap1 was critical for the repression of homology-directed repair (HDR), which can alter telomere length. The data reveal that HDR at telomeres can take place in the absence of DNA damage foci and underscore the functional compartmentalization within shelterin.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864730/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864730/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sfeir, Agnel -- Kabir, Shaheen -- van Overbeek, Megan -- Celli, Giulia B -- de Lange, Titia -- AG016642/AG/NIA NIH HHS/ -- GM049046/GM/NIGMS NIH HHS/ -- R01 AG016642/AG/NIA NIH HHS/ -- R01 AG016642-01/AG/NIA NIH HHS/ -- R01 AG016642-02/AG/NIA NIH HHS/ -- R01 AG016642-03/AG/NIA NIH HHS/ -- R01 AG016642-04/AG/NIA NIH HHS/ -- R01 AG016642-05/AG/NIA NIH HHS/ -- R01 AG016642-06/AG/NIA NIH HHS/ -- R01 AG016642-07/AG/NIA NIH HHS/ -- R01 AG016642-08/AG/NIA NIH HHS/ -- R01 AG016642-09/AG/NIA NIH HHS/ -- R01 AG016642-10/AG/NIA NIH HHS/ -- R01 AG016642-11/AG/NIA NIH HHS/ -- R01 GM049046/GM/NIGMS NIH HHS/ -- R01 GM049046-07/GM/NIGMS NIH HHS/ -- R01 GM049046-08/GM/NIGMS NIH HHS/ -- R01 GM049046-09/GM/NIGMS NIH HHS/ -- R01 GM049046-10/GM/NIGMS NIH HHS/ -- R01 GM049046-11/GM/NIGMS NIH HHS/ -- R01 GM049046-12/GM/NIGMS NIH HHS/ -- R37 GM049046/GM/NIGMS NIH HHS/ -- R37 GM049046-13/GM/NIGMS NIH HHS/ -- R37 GM049046-14/GM/NIGMS NIH HHS/ -- R37 GM049046-15/GM/NIGMS NIH HHS/ -- R37 GM049046-16/GM/NIGMS NIH HHS/ -- R37 GM049046-17/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Mar 26;327(5973):1657-61. doi: 10.1126/science.1185100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20339076" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Cell Proliferation ; Cells, Cultured ; Checkpoint Kinase 2 ; *DNA Damage ; *DNA Repair ; DNA-Binding Proteins/metabolism ; Gene Deletion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Molecular Sequence Data ; Protein-Serine-Threonine Kinases/metabolism ; Recombination, Genetic ; Signal Transduction ; Sister Chromatid Exchange ; Telomere/*genetics/metabolism ; Telomere-Binding Proteins/chemistry/*genetics/*metabolism ; Telomeric Repeat Binding Protein 2/genetics/metabolism ; Tumor Suppressor Proteins/metabolism
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    Science for physicians (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooke, Molly -- New York, N.Y. -- Science. 2010 Sep 24;329(5999):1573. doi: 10.1126/science.1197542.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929814" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*education ; Curriculum ; *Education, Medical ; Education, Medical, Undergraduate ; Humans ; Natural Science Disciplines/*education ; Teaching ; United States
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    Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-19
    Description: Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a protein previously linked to the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages that was associated with activation of the c-Jun N-terminal kinase signaling pathway. Adenovirus-mediated delivery of Sfrp5 to mouse models of obesity ameliorated glucose intolerance and hepatic steatosis. Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132938/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132938/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ouchi, Noriyuki -- Higuchi, Akiko -- Ohashi, Koji -- Oshima, Yuichi -- Gokce, Noyan -- Shibata, Rei -- Akasaki, Yuichi -- Shimono, Akihiko -- Walsh, Kenneth -- AG15052/AG/NIA NIH HHS/ -- AG34972/AG/NIA NIH HHS/ -- HL81587/HL/NHLBI NIH HHS/ -- HL86785/HL/NHLBI NIH HHS/ -- P01 HL081587/HL/NHLBI NIH HHS/ -- P01 HL081587-05/HL/NHLBI NIH HHS/ -- R01 AG015052/AG/NIA NIH HHS/ -- R01 AG015052-06/AG/NIA NIH HHS/ -- R01 AG034972/AG/NIA NIH HHS/ -- R01 AG034972-03/AG/NIA NIH HHS/ -- R01 HL086785/HL/NHLBI NIH HHS/ -- R01 HL086785-19/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):454-7. doi: 10.1126/science.1188280. Epub 2010 Jun 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. nouchi@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20558665" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3-L1 Cells ; Adipocytes/*metabolism/pathology ; Adipokines/genetics/*metabolism ; Adipose Tissue/*metabolism/pathology ; Animals ; Dietary Fats/administration & dosage ; Dietary Sucrose/administration & dosage ; Fatty Liver/pathology/therapy ; Genetic Vectors ; Glucose/metabolism ; Humans ; Inflammation ; Insulin/metabolism ; Insulin Resistance ; Intercellular Signaling Peptides and Proteins/genetics/*metabolism ; Macrophages/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mitogen-Activated Protein Kinase 8/genetics/metabolism ; Obesity/*metabolism/pathology ; Phosphorylation ; Rats ; Rats, Zucker ; Signal Transduction ; Wnt Proteins/metabolism
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    Science and the law. With stem cells in court, a history primer (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2010 Sep 17;329(5998):1450-1. doi: 10.1126/science.329.5998.1450.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20847238" target="_blank"〉PubMed〈/a〉
    Keywords: Embryo Research/economics/history/*legislation & jurisprudence ; *Embryonic Stem Cells ; Financing, Government/history/legislation & jurisprudence ; Guidelines as Topic ; History, 20th Century ; History, 21st Century ; Humans ; Induced Pluripotent Stem Cells ; National Institutes of Health (U.S.)/economics/history/*legislation & ; jurisprudence ; Research Support as Topic/history/*legislation & jurisprudence ; United States
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  • 92
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    Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-12
    Description: The maintenance of a progenitor cell population as a reservoir of undifferentiated cells is required for organ development and regeneration. However, the mechanisms by which epithelial progenitor cells are maintained during organogenesis are poorly understood. We report that removal of the parasympathetic ganglion in mouse explant organ culture decreased the number and morphogenesis of keratin 5-positive epithelial progenitor cells. These effects were rescued with an acetylcholine analog. We demonstrate that acetylcholine signaling, via the muscarinic M1 receptor and epidermal growth factor receptor, increased epithelial morphogenesis and proliferation of the keratin 5-positive progenitor cells. Parasympathetic innervation maintained the epithelial progenitor cell population in an undifferentiated state, which was required for organogenesis. This mechanism for epithelial progenitor cell maintenance may be targeted for organ repair or regeneration.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376907/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376907/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knox, S M -- Lombaert, I M A -- Reed, X -- Vitale-Cross, L -- Gutkind, J S -- Hoffman, M P -- Z99 DE999999/Intramural NIH HHS/ -- ZIA DE000707-08/Intramural NIH HHS/ -- ZIA DE000722-04/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2010 Sep 24;329(5999):1645-7. doi: 10.1126/science.1192046.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929848" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Carbachol/metabolism/pharmacology ; Cell Differentiation ; Epithelial Cells/cytology/*physiology ; Epithelium/embryology/innervation ; Ganglia, Parasympathetic/cytology/embryology/*physiology ; Heparin-binding EGF-like Growth Factor ; Intercellular Signaling Peptides and Proteins/metabolism/pharmacology ; Keratin-5/analysis/genetics ; Male ; Mice ; Morphogenesis/drug effects ; Neurons/cytology/*physiology ; Organ Culture Techniques ; *Organogenesis ; Prostate/cytology/embryology/innervation ; Quinazolines/pharmacology ; Receptor, Epidermal Growth Factor/metabolism ; Receptor, Muscarinic M1/metabolism ; Regeneration ; Signal Transduction ; Stem Cells/cytology/*physiology ; Submandibular Gland/cytology/*embryology/*innervation
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    Immunology. CAR'ing for the skin (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-09-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, Andrey S -- Huang, Yina -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Sep 3;329(5996):1154-5. doi: 10.1126/science.1195337.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. shaw@pathology.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20813941" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion Molecules/chemistry/*metabolism ; Coxsackie and Adenovirus Receptor-Like Membrane Protein ; Crystallization ; Epidermis/*immunology/metabolism/ultrastructure ; Hydrogen Bonding ; Ligands ; Lymphocyte Activation ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptors, Antigen, T-Cell, gamma-delta/*immunology/metabolism ; Receptors, Virus/chemistry/*metabolism ; Signal Transduction ; T-Lymphocyte Subsets/*immunology/*metabolism ; Tight Junctions/metabolism
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    Maize tumors caused by Ustilago maydis require organ-specific genes in host and pathogen (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-03
    Description: Infection of maize by corn smut (Ustilago maydis) provides an agronomically important model of biotrophic host-pathogen interactions. After penetration of the maize epidermis, fungal colonization of host tissue induces tumor formation on all aerial maize organs. We hypothesized that transformation of different primordia into plant tumors would require organ-specific gene expression by both host and pathogen and documented these differences by transcriptome profiling. Phenotypic screening of U. maydis mutants deleted for genes encoding secreted proteins and maize mutants with organ-specific defects confirmed organ-restricted tumorigenesis. This is the foundation for exploring how individual pathogen effectors, deployed in an organ-specific pattern, interact with host factors to reprogram normal ontogeny into a tumor pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skibbe, David S -- Doehlemann, Gunther -- Fernandes, John -- Walbot, Virginia -- New York, N.Y. -- Science. 2010 Apr 2;328(5974):89-92. doi: 10.1126/science.1185775.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20360107" target="_blank"〉PubMed〈/a〉
    Keywords: Flowers/genetics/microbiology ; Gene Expression ; Gene Expression Profiling ; Gene Expression Regulation, Fungal ; Gene Expression Regulation, Plant ; Genes, Fungal ; Genes, Plant ; Gibberellins/metabolism ; Host-Pathogen Interactions ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Plant Leaves/genetics/microbiology ; Plant Tumors/*genetics/*microbiology ; Seedlings/genetics/microbiology ; Signal Transduction ; Up-Regulation ; Ustilago/*genetics/*physiology ; Zea mays/*genetics/*microbiology
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    A new focus on plant sciences (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormick, Steven J -- Tjian, Robert -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Nov 19;330(6007):1021. doi: 10.1126/science.1198153.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21097906" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*economics ; Botany/*economics ; Financing, Government ; *Plants ; *Research Support as Topic ; United States
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    What is STEM education? (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bybee, Rodger W -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):996. doi: 10.1126/science.1194998.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798284" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Child ; Education/legislation & jurisprudence ; Engineering/*education ; Humans ; Mathematics/*education ; Science/*education ; Technology/*education ; United States
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    Intravascular danger signals guide neutrophils to sites of sterile inflammation (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-16
    Description: Neutrophils are recruited from the blood to sites of sterile inflammation, where they contribute to wound healing but may also cause tissue damage. By using spinning disk confocal intravital microscopy, we examined the kinetics and molecular mechanisms of neutrophil recruitment to sites of focal hepatic necrosis in vivo. Adenosine triphosphate released from necrotic cells activated the Nlrp3 inflammasome to generate an inflammatory microenvironment that alerted circulating neutrophils to adhere within liver sinusoids. Subsequently, generation of an intravascular chemokine gradient directed neutrophil migration through healthy tissue toward foci of damage. Lastly, formyl-peptide signals released from necrotic cells guided neutrophils through nonperfused sinusoids into the injury. Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McDonald, Braedon -- Pittman, Keir -- Menezes, Gustavo B -- Hirota, Simon A -- Slaba, Ingrid -- Waterhouse, Christopher C M -- Beck, Paul L -- Muruve, Daniel A -- Kubes, Paul -- Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2010 Oct 15;330(6002):362-6. doi: 10.1126/science.1195491.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Research Group, University of Calgary, Alberta T2N 4N1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20947763" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Carrier Proteins/metabolism ; Cell Adhesion ; Chemokine CXCL2/metabolism ; Chemokines/metabolism ; Chemotaxis, Leukocyte ; Cues ; Endothelium, Vascular/physiology ; Inflammation/*immunology/metabolism/*pathology ; Kinetics ; Liver/blood supply/*immunology/metabolism/*pathology ; Liver Diseases/*immunology/metabolism/*pathology ; Macrophage-1 Antigen/physiology ; Mice ; Microscopy/methods ; Microscopy, Confocal ; Microvessels/physiology ; Necrosis ; *Neutrophil Infiltration ; Neutrophils/physiology ; Peptides/metabolism ; Receptors, Formyl Peptide/metabolism ; Receptors, Interleukin-8B/metabolism ; Receptors, Purinergic P2/metabolism ; Receptors, Purinergic P2X7 ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Next-generation assessments (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shepard, Lorrie A -- New York, N.Y. -- Science. 2010 Nov 12;330(6006):890. doi: 10.1126/science.1199897.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21071634" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Child ; Education/standards ; *Educational Measurement ; Humans ; Learning ; Mathematics/*education ; Science/*education ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Eppendorf winner. 2010 Grand Prize winner (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-11-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2010 Nov 5;330(6005):771. doi: 10.1126/science.330.6005.771.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21051626" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Canada ; History, 21st Century ; *Neurobiology/history ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    U.S. science policy. Obama's nominee to lead NSF lauded for science and management skills (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2010 Jun 11;328(5984):1340-1. doi: 10.1126/science.328.5984.1340-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20538922" target="_blank"〉PubMed〈/a〉
    Keywords: Engineering/history ; History, 20th Century ; History, 21st Century ; India ; Public Policy ; *Science ; United States ; United States Government Agencies/*organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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