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  • 1
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    Fgf10 gene regulation during cardiogenesis [Developmental Biology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-11-08
    Description: During cardiogenesis, Fibroblast Growth Factor (Fgf10) is expressed in the anterior second heart field. Together with Fibroblast growth factor 8 (Fgf8), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of the heart. We have identified a 1.7-kb region in the first intron of Fgf10...
    Keywords: Inaugural Articles
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides [Medical Sciences] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-08-24
    Description: Heparan sulfate proteoglycans (HSPGs) are ubiquitous components of pathologic amyloid deposits in the organs of patients with disorders such as Alzheimer's disease or systemic light chain (AL) or reactive (AA) amyloidosis. Molecular imaging methods for early detection are limited and generally unavailable outside the United Kingdom. Therefore, there is an urgent need to develop novel, specific amyloidophilic radiotracers for imaging to assist in diagnosis, prognostication, and monitoring response to therapy. Amyloid-associated HSPG can be differentiated from HSPG found in surrounding healthy cells and tissues by the preferential binding of certain HS-reactive single chain variable fragments and therefore, represents a biomarker that can be targeted specifically with appropriate reagents. Using a murine model of AA amyloidosis, we have examined the in vivo amyloid reactivity of seven heparin-binding peptides by using single photon emission and X-ray computed tomographic imaging, microautoradiography, and tissue biodistribution measurements. All of the peptides bound amyloid deposits within 1 h post-injection, but the extent of the reactivity differed widely, which was evidenced by image quality and grain density in autoradiographs. One radiolabeled peptide bound specifically to murine AA amyloid in the liver, spleen, kidney, adrenal, heart, and pancreas with such avidity that it was observed in single photon emission tomography images as late as 24 h post-injection. In addition, a biotinylated form of this peptide was shown histochemically to bind human AA, ALκ, ALλ, transthyretin amyloidosis (ATTR), and Aβ amyloid deposits in tissue sections. These basic heparin-binding peptides recognize murine and human amyloid deposits in both in vivo and ex vivo tissues and therefore, have potential as radiotracers for the noninvasive molecular imaging of amyloid deposits in situ.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Moloney murine leukemia virus integrase and reverse transcriptase interact with PML proteins (2012)
    Oxford University Press
    Details
    Publication Date: 2012-07-28
    Description: Pull-down assay and co-immunoprecipitation of cell extracts in which the integrase or reverse transcriptase of Moloney murine leukemia virus was transiently expressed showed that both enzymes interacted with PML proteins. In infected cells, interaction between the integrase and PML was also observed. Transient expression of PIASy and SUMO proteins facilitated SUMOylation of the integrase but had no apparent effects on the interaction with PML. A FLAG-tagged integrase co-localized with PML protein possibly in the PML body. Knockdown of PML by small interfering RNA resulted in reduced viral cDNA levels and integration efficiency. This suggested that PML proteins activated reverse transcription.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
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  • 4
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    Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-01
    Description: An inhibitor of coagulation factor XIa was purified from serum-free conditioned medium of HepG2 liver cells. Platelets stimulated with thrombin or calcium ionophore (A23187) secrete a protein functionally and immunologically identical to the inhibitor, implying a role for this inhibitor in hemostasis. Analysis of the amino-terminal amino acid sequence and immunologic reactivity showed the inhibitor to be a truncated form of the Alzheimer's amyloid precursor protein that contains a Kunitz-type serine protease inhibitor domain and at least a portion of the amyloid beta protein. It inhibits factor XIa and trypsin with a Ki of 450 +/- 50 pM and 20 +/- 10 pM, respectively. Heparin (1 unit/ml) did not significantly effect inhibition of trypsin, but inhibition of XIa was 15 times greater (Ki = 25 +/- 15 pM) in the presence of heparin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R P -- Higuchi, D A -- Broze, G J Jr -- New York, N.Y. -- Science. 1990 Jun 1;248(4959):1126-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2111585" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amyloid/immunology ; Amyloid beta-Protein Precursor ; Blood Platelets/*analysis ; Blood Proteins/immunology/*isolation & purification/physiology ; Cross Reactions ; Factor XIa/*antagonists & inhibitors ; Humans ; Molecular Sequence Data ; Protein Precursors/immunology ; Serine Proteinase Inhibitors/blood/*isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-19
    Description: Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a protein previously linked to the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes. Sfrp5-deficient mice fed a high-calorie diet developed severe glucose intolerance and hepatic steatosis, and their adipose tissue showed an accumulation of activated macrophages that was associated with activation of the c-Jun N-terminal kinase signaling pathway. Adenovirus-mediated delivery of Sfrp5 to mouse models of obesity ameliorated glucose intolerance and hepatic steatosis. Thus, in the setting of obesity, Sfrp5 secretion by adipocytes exerts salutary effects on metabolic dysfunction by controlling inflammatory cells within adipose tissue.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132938/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132938/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ouchi, Noriyuki -- Higuchi, Akiko -- Ohashi, Koji -- Oshima, Yuichi -- Gokce, Noyan -- Shibata, Rei -- Akasaki, Yuichi -- Shimono, Akihiko -- Walsh, Kenneth -- AG15052/AG/NIA NIH HHS/ -- AG34972/AG/NIA NIH HHS/ -- HL81587/HL/NHLBI NIH HHS/ -- HL86785/HL/NHLBI NIH HHS/ -- P01 HL081587/HL/NHLBI NIH HHS/ -- P01 HL081587-05/HL/NHLBI NIH HHS/ -- R01 AG015052/AG/NIA NIH HHS/ -- R01 AG015052-06/AG/NIA NIH HHS/ -- R01 AG034972/AG/NIA NIH HHS/ -- R01 AG034972-03/AG/NIA NIH HHS/ -- R01 HL086785/HL/NHLBI NIH HHS/ -- R01 HL086785-19/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):454-7. doi: 10.1126/science.1188280. Epub 2010 Jun 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Cardiology and Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. nouchi@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20558665" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3-L1 Cells ; Adipocytes/*metabolism/pathology ; Adipokines/genetics/*metabolism ; Adipose Tissue/*metabolism/pathology ; Animals ; Dietary Fats/administration & dosage ; Dietary Sucrose/administration & dosage ; Fatty Liver/pathology/therapy ; Genetic Vectors ; Glucose/metabolism ; Humans ; Inflammation ; Insulin/metabolism ; Insulin Resistance ; Intercellular Signaling Peptides and Proteins/genetics/*metabolism ; Macrophages/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mitogen-Activated Protein Kinase 8/genetics/metabolism ; Obesity/*metabolism/pathology ; Phosphorylation ; Rats ; Rats, Zucker ; Signal Transduction ; Wnt Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    A new apparatus for measuring elastic wave velocity and electrical conductivity of fluid-saturated rocks at various confining and pore-fluid pressures (2013)
    Wiley
    In: Geofluids
    Details
    Publication Date: 2013-07-16
    Description: Pore-fluid pressure is a critical parameter that governs geodynamic processes including seismic activities. Its evaluation through geophysical observations provides us insights into these processes. The quantitative evaluation requires a thorough understanding of the influence of pore-fluid pressure on geophysical parameters, such as seismic velocity and electrical conductivity. To study the influence of pore-fluid pressure on these parameters, we have built a new apparatus with a pore-fluid pressure control system, which is capable of simultaneously measuring elastic wave velocity and electrical conductivity. Our new apparatus employs two sets of plastic piston–cylinders for the electrical insulation and pore-fluid pressure transmission. The pore fluid is electrically isolated from the metal work, and its pressure can be precisely controlled without significant contribution of the friction between the piston and cylinder. Our new apparatus was used for a simultaneous measurement of velocity and conductivity in a brine-saturated Berea sandstone. Elastic wave velocity and electrical conductivity changed in response to the change in confining and pore-fluid pressures, showing the usefulness of the new apparatus. In order to study the influence of pore-fluid pressure on elastic wave velocity and electrical conductivity, we have built a new apparatus with a pore-fluid pressure control system, which is capable of simultaneously measuring velocity and conductivity. Our new apparatus employs plastic piston-cylinders for the electrical insulation and pore-fluid pressure transmission. The pore-fluid is electrically isolated from the metal work, and its pressure can be precisely controlled without significant contribution of the friction between the piston and cylinder.
    Print ISSN: 1468-8115
    Electronic ISSN: 1468-8123
    Topics: Geosciences
    Published by Wiley
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  • 7
    Electronic Resource
    Electronic Resource
    Multipartite generalization of the Schmidt decomposition (2000)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 41 (2000), S. 7932-7939 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: We find a canonical form for pure states of a general multipartite system, in which the constraints on the coordinates (with respect to a factorizable orthonormal basis) are simply that certain ones vanish and certain others are real. For identical particles they are invariant under permutations of the particles. As an application, we find the dimension of the generic local equivalence class. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1319516
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  • 8
    Electronic Resource
    Electronic Resource
    Group quantization of parametrized systems. II. Pasting Hilbert spaces (1995)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 36 (1995), S. 4639-4666 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The method of group quantization described in the preceding paper [J. Math. Phys. 36, 4612 (1995)] is extended so that it becomes applicable to some parametrized systems that do not admit a global transversal surface. A simple completely solvable toy model is studied that admits a pair of maximal transversal surfaces intersecting all orbits. The corresponding two quantum mechanics are constructed. The similarity of the canonical group actions in the classical phase spaces on the one hand and in the quantum Hilbert spaces on the other hand suggests how the two Hilbert spaces are to be pasted together. The resulting quantum theory is checked to be equivalent to that constructed directly by means of Dirac's operator constraint method. The complete system of partial Hamiltonians for any of the two transversal surfaces is chosen and the quantum Schrödinger or Heisenberg pictures of time evolution are constructed. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.530912
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  • 9
    Electronic Resource
    Electronic Resource
    Steroidogenesis in liposomal system containing adrenal microsomal cytochrome P-450 electron transfer components
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 985 (1989), S. 293-299 
    Details
    ISSN: 0005-2736
    Keywords: Cytochrome P-450"1"7"α","l"y"a"s"e ; Cytochrome P-450"C"2"1 ; Liposome ; NADPH-cytochrome-P-450 reductase ; Steroidogenesis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2736(89)90415-X
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  • 10
    Electronic Resource
    Electronic Resource
    Interaction of steroids with adrenal cytochrome P-450 (P-450"1"7"α","l"y"a"s"e) in liposome membranes
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 937 (1988), S. 177-183 
    Details
    ISSN: 0005-2736
    Keywords: (Guinea-pig adrenal cortex) ; Cytochrome P-450"1"7"α","l"y"a"s"e ; Liposome ; Steroid partitioning ; Substrate binding
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(88)90239-8
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