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  • Humans  (680)
  • Geophysics  (179)
  • Fisheries
  • Industrial Chemistry
  • 2005-2009  (883)
  • 1950-1954
  • 2005  (883)
  • 1
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    Publication Date: 2017-04-03
    Description: Geophysics Open archive. Free access to worldwide scientists during search and submission process. Earth-Prints is an open archive created and maintained by Istituto Nazionale di Geofisica e Vulcanologia with the collaboration of Programma Nazionale Ricerche in Antartide. It is maintained by CILEA .
    Description: Unpublished
    Description: Rome, Italy
    Description: open
    Keywords: Open Access ; Geophysics ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Oral presentation
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  • 2
    Publication Date: 2020-03-02
    Description: The present paper describes a multidisciplinary approach to the evaluation of a seismically triggered landslide that occurred in the Cerda area (Italy) on September 6, 2002, about 1 h after an earthquake took place in the south Tyrrhenian Sea. The study was focused on an analysis of the role of the seismic input in triggering the landslide, in view of the evidence that no other mass movement was recorded in the adjacent areas despite geological and geomorphological spatial homogeneity. The studied area is located on a slope of the western flank of the Fiume Imera Settentrionale (Northern Sicily), which is made up of clayey–arenitic rocks. The slope inclines gently but is not uniform due to fluvial, gravitative, and rainwash processes. Field data dealing with global positioning system (GPS), geology, geomorphology, geophysics (vertical electrical sounding, or VES), and geochemistry (soil gas fluxes and composition) were acquired and analysed in order to investigate the cause–effect relationships between the earthquake and the mass movement. The GPS survey allowed us to map the ground failures that have also been classified on the basis of their kinematical meaning (i.e., compressive, distensive, or transcurrent structures). The geological analysis revealed outcropping rocks and tectonic structures. The geomorphologic survey highlighted the presence of preexisting landslide bodies. The geophysical survey detected a buried surface located at a depth of about 100 m . Finally, the geochemical survey showed that the gas released from the displaced mass came from a shallow depth and was not related to any active fault system. The abovementioned information allowed us to interpret the landslide event as a partial reactivation of a preexisting landslide body that was triggered by the earthquake.
    Description: Ministero dell’Istruzione, dell’Universita` e della Ricerca (MIUR), Cofinanziamento Progetti di Ricerca di Rilevante Interesse Nazionale (COFIN PRIN) 2002 Project "Valutazione dell’Erosione del Suolo in Ambiente Mediterraneo"
    Description: Published
    Description: 101–116
    Description: partially_open
    Keywords: Landslide ; Earthquake ; Geochemistry ; Geophysics ; GPS ; Triggering mechanism ; 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2021-05-19
    Description: The present paper is based on a collation of information, through both a literature review and an internet search, on North American programs that involve some kind of scientific collaboration between fishers and fisheries scientists. It identifies four basic models of such collaboration and offers examples of collaborative activities that seem to fit into each of them. The first model defers to the expertise of the scientist for all major decisions and creates a strong programmatic distinction between what is science, and shall be done by scientists, and what are other, related activities that can be carried out by others. Various kinds of tagging programs, fisher advisory boards, at-sea research collaboration and many other activities fit this model. The second model, traditional ecological knowledge, recognizes that fishers have available to them a unique, local knowledge of the resource that can make a supplementary contribution to fisheries science. Several government, community and environmental groups are engaged in finding, recording and using this knowledge....
    Description: Unpublished
    Keywords: Mariculture ; Fisheries
    Repository Name: AquaDocs
    Type: Conference Material , Non-Refereed , Paper
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  • 4
    Publication Date: 2021-01-30
    Description: Dr Sebek introduced the ACOPS report which sums up the activities undertaken since the last Preparatory Committee meeting all of which are detailed in Annex V. In particular, Dr Sebek said that several strategic partnerships were being forged in order that certain components of the work programme, as agreed at the First Preparatory Committee Meeting in Nairobi in February, could start as soon as possible. A good example of such a policy, in the field of root cause analyses was the anticipated co-operation with UNESCO.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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  • 5
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    UNEP; Regional Activity Centre for Specially Protected Areas (RAC/SPA)
    Publication Date: 2021-05-19
    Description: At present, the impact of accidental catch on sea turtle populations is one of the most urgent problems that must be solved to ensure the survival of all these species worldwide. In the Mediterranean, too, all marine turtle species are affected by fishing activities, in particular the loggerhead (Caretta caretta) and the green (Chelonia mydas) turtles, which are more common than the others and are the only ones breeding in this sea. Since the Mediterranean populations of both species seem to be genetically isolated from the Atlantic ones (Bowen et al., 1992; Bowen et al., 1993; Laurent et al., 1993), fishing-induced mortality probably cannot be counterbalanced by immigration. This implies that the survival of the Mediterranean populations of these species depends to a great extent on the conservation effort that the Mediterranean countries carry on in the near future to reduce accidental mortality.
    Description: Unpublished
    Keywords: Marine turtles ; Fisheries
    Repository Name: AquaDocs
    Type: Working Paper , Non-Refereed
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  • 6
    Publication Date: 2021-05-19
    Description: The coastal waters of West Africa are among the world's richest fishing grounds ... for the time being. Droughts have ravaged the hinterland and as a result people have steadily moved towards the shores of Senegal and Mauritania. At the same time the international fishing industry seems intent on exploiting West African waters to a greater and greater extent. Nicolien Zuijdgeest and photographer Bas Beentjes visited the region and found that the sustainability of fisheries is being seriously threatened.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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  • 7
    Publication Date: 2021-05-19
    Description: Le Gabon est situé en Afrique centrale avec une façade atlantique . Il est limité au Nord par le Cameroun, au Nord-ouest par la Guinée Equatoriale, à l’Est et au Sud par le Congo. La zone économique exclusive (ZEE) a une surface de 213.000 Km². elle est plus vaste que celle de Sao-Tomé et Principé, pays insulaire voisin (160.000 Km²). La façade maritime à une longueur de 750 Km , de Coccobeach à Ndindi. La largeur moyenne du plateau continental est de 60 Km, soit une surface à peu-près de 40.600 Km² de la côte à l’isobathe de 200 mètres. Ce plateau se termine par un talus peu abrupt, d’une longueur de 750 Km et d’une superficie de 11.200 Km² entre 200 et 800 mètres de profondeur....
    Description: Unpublished
    Keywords: Biodiversity ; Environments ; Fisheries
    Repository Name: AquaDocs
    Type: Working Paper , Non-Refereed
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  • 8
    Publication Date: 2021-05-19
    Description: In 1997, IUCN-The World Conservation Union, with the financial support of the German Federal Ministry for Economic Co-operation and Development, initiated a project to examine the relationship between the Convention on Biological Diversity (CBD) and the rules of international trade–those administered by the World Trade Organisation (WTO), in particular. The project was motivated by a widely shared concern that the aims of the CBD, which are essentially to conserve and equitably distribute the benefits of the environment, might be undermined by the WTO, which aims at the liberalisation of trade. Liberalised trade has the potential to integrate economies, regionally and globally, in mutually beneficial ways. But some observers are concerned that it may do so at a cost of impairing the environment and amplifying disparities in wealth, much of which, in poorer nations, is disproportionately represented in endowments of natural resources. Other commentators have claimed to locate synergistic potential, suggesting, for example, that trade law’s anti-subsidy disciplines might be conscripted into the campaign against environmental abuses such as overfishing.
    Keywords: Biodiversity ; International trade ; Fisheries
    Repository Name: AquaDocs
    Type: Conference Material , Non-Refereed , Paper
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  • 9
    Publication Date: 2021-05-19
    Description: This synopsis describes the development of marine biological research, including fisheries, in Mozambique. With around 3000 km of coastline, the living resources of the sea playa major role in the Mozambican society, mainly as a source of protein and income for the population, and of foreign revenue through exports. In the first years, after independence, in 1975, research activities in marine sciences were limited and mainly concentrated to fisheries through cooperation with Norway and the Soviet Union. A new era for biology started in 1985 when the Faculty of Biology at Universidade Eduardo Mondlane was re-opened. A 5yr curriculum towards a licentiate degree was introduced with a strong marine profile. Since the 1990s, a very dynamic de-velopment in Mozambican marine biological research has occurred. Several academic degrees in marine biology from universities abroad were obtained, and local expertise developed; building vital institutions and enrolling in advanced research activities.
    Description: Published
    Keywords: Marine biology ; Fisheries
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed , Article
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  • 10
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    FAO
    Publication Date: 2021-01-30
    Description: Published
    Description: Eritrea
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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  • 11
    Publication Date: 2021-05-19
    Description: Cette rencontre entre dans le cadre du programme conjoint de recherche sur les crustacés entre l’IMROP et l’IEO (Espagne)
    Description: Published
    Keywords: Captures ; Effort de pêche ; Length distribution ; Fishing effort ; CPUE ; Débarquement ; Landing ; Pêcheries ; Mauritanie ; Fisheries ; Accords de pêche ; UE ; Mauritania ; Crevettes ; Shrimps ; EU ; Distribution de taille ; Fishing fleet ; Fishing agreements ; Flottille de pêche ; Catches ; Crustacean fisheries
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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  • 12
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    International Centre for Trade and Sustainable Development (ICTSD) and IUCN-The World Conservation Union
    Publication Date: 2021-05-19
    Description: The Fisheries, International Trade, and Sustainable Development programme aims to inject both the sustainable development and natural resource management perspectives into the debate on trade and fisheries. The ultimate objective of the programme is to make international trade in fisheries supportive of sustainable development. The programme's main activity will be to convene a series of policy dialogues on fisheries, international trade, and sustainable development which will link processes and actors, and bring together all the different stakeholders' perspectives. Initially the programme aims to facilitate a process in which each stakeholder can move beyond the constraints inherent in his or her position, to enable all participants to step back from particular debates and stand-offs regarding fisheries, trade, and sustainable development-related issues such as subsidies, ecolabelling, or conservation measures. The dialogues, research, and information exchange process will seek to build common understanding and a baseline of shared information, and pave the way for participating stakeholders to seek solutions compatible with the aims of sustainable development by exploring ways to improve resource management while safeguarding the livelihoods of those who depend on fisheries, and ensuring economic growth for developing countries.
    Description: International Centre for Trade and Sustainable Development, IUCN — The World Conservation Union Publications Service Unit
    Description: Published
    Keywords: Sustainable development ; Fisheries ; International trade
    Repository Name: AquaDocs
    Type: Book Section , Non-Refereed
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  • 13
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    Accra : Marine Fisheries Research Division
    Publication Date: 2021-05-19
    Description: Ministry of Food and Agriculture
    Description: Directorate of Fisheries
    Description: Published
    Description: Exploitation, Upwelling, Pelagic species, Demersal species, Atlantic Ocean
    Keywords: Fishery policy ; Marine environment ; Fisheries ; Exploitation
    Repository Name: AquaDocs
    Type: Report , Non-Refereed
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  • 14
    Publication Date: 2021-05-19
    Description: The marine fisheries production from African coastal countries, combined with that of freshwater production of the continent is estimated to be 6 millions metric tons, corresponding only 5 % of the total world production. Africa's contribution to fisheries products (1,5 %) is insignificant compared to that of world commerce which is around 44 millions tons. This deplorable situation is due to a certain number of problems which include s among others, the relative biogenic poverty of African waters, the exploitation of African waters by foreign vessels, the total lack of catches effected by the African vessels out of their regional boundaries, the lack of knowledge on the mastering of commercialisation and on veritable commercial politics of fisheries products, including quality assurance. In addition to this, the almost inexistence of the aquaculture in the sub-Saharan countries. This paper analyses the African fisheries in the whole continent and presents the general characters, notably its evolution, fisheries resources, valorisation and consumption of fisheries products. The global analysis made here accords a priority to markets as well as to the framework of contribution of these products and tries, at the end of the 20th century, to present some trends. Facing the globalisation phenomena, how will African fisheries producers be challenged in the new millennium? This continental level analysis brings out field application and some different development perspectives for both small scale and industrial fisheries sub-sectors.
    Description: Published
    Keywords: Fisheries
    Repository Name: AquaDocs
    Type: Proceedings Paper , Non-Refereed
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  • 15
    Publication Date: 2022-05-25
    Description: The primary objective of this publication is to share with a wider audience the valuable information and extensive dialogue that took place amongst over 140 individuals who attended the second in a series of planned workshops on the science and management of coastal landforms in Massachusetts. This workshop took place at the Woods Hole Oceanographic Institution on January 24, 2001. The individuals who attended this workshop are actively engaged in planning, managing, regulating, engineering, educating, and studying coastal landforms and their beneficial functions. This workshop titled, Can Humans & Coastal Landforms Co-exist?’, was a natural follow-up to a previous workshop, Coastal Landform Management in Massachusetts, held at WHOI October 9-10, 1997 (proceedings published as WHOI Technical Report #WHOI-98-16). The workshop had a very practical, applied focus, providing state-of-the-art scientific understanding of coastal landform function, case history management and regulation of human activities proposed on coastal landforms, a multi-faceted mock conservation commission hearing presented by practicing technical consultants and attorneys that involved all attendees acting as regulators in breakout sessions, and, at the conclusion of the workshop, an open discussion on all issues related to the science and management of coastal landforms, including future research needs.
    Description: Funding for these proceedings was provided by WHOI Sea Grant and the NOAA National Sea Grant College Program Office, Department of Commerce, under NOAA Grant No. M10-2, Woods Hole Oceanographic Institution Sea Grant Project No. NA86R60075.
    Keywords: Coastal ; Landforms ; Humans
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
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  • 16
    Publication Date: 2005
    Keywords: Subduction zone ; Plate tectonics ; decollement ; Geol. aspects ; Ocean Drilling Program ; GRL ; 0500 ; Computational ; Geophysics ; (3200, ; 3252, ; 7833) ; 0900 ; Exploration ; Geophysics ; 3000 ; Marine ; Geology ; and ; Geophysics ; 8000 ; Structural ; Geology ; 8100 ; Tectonophysics
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: Converging legal and scientific forces are pushing the traditional forensic identification sciences toward fundamental change. The assumption of discernible uniqueness that resides at the core of these fields is weakened by evidence of errors in proficiency testing and in actual cases. Changes in the law pertaining to the admissibility of expert evidence in court, together with the emergence of DNA typing as a model for a scientifically defensible approach to questions of shared identity, are driving the older forensic sciences toward a new scientific paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saks, Michael J -- Koehler, Jonathan J -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):892-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Law, Arizona State University, Tempe, AZ 85287, USA. saks@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081727" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/classification ; Expert Testimony ; Forecasting ; Forensic Sciences/legislation & jurisprudence/*trends ; Humans ; Models, Theoretical ; Reproducibility of Results
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohman, James C -- Lovejoy, C Owen -- White, Tim D -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):845; author reply 845.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15709231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Femoral Neck Fractures/pathology ; Femur/*anatomy & histology/radiography ; Femur Neck/anatomy & histology/radiography ; *Fossils ; Hominidae/*anatomy & histology/physiology ; Humans ; Locomotion ; Tomography, X-Ray Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1550.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761133" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/anatomy & histology/*pathology ; Brain Diseases/*diagnosis ; *Diagnostic Imaging ; Humans ; *Incidental Findings ; *Research Subjects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1857.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790821" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Cell Line ; Cloning, Organism ; *Embryo Research/economics/legislation & jurisprudence ; Embryo, Mammalian/*cytology ; Humans ; *Research Support as Topic/legislation & jurisprudence ; *Stem Cells ; Tissue Donors/legislation & jurisprudence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1548-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761132" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/*anatomy & histology/*physiology ; Confidentiality ; Deception ; *Diagnostic Imaging ; Humans ; *Mental Processes ; *Personality ; *Privacy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: Dominance hierarchies occur in numerous social species, and rank within them can greatly influence the quality of life of an animal. In this review, I consider how rank can also influence physiology and health. I first consider whether it is high- or low-ranking animals that are most stressed in a dominance hierarchy; this turns out to vary as a function of the social organization in different species and populations. I then review how the stressful characteristics of social rank have adverse adrenocortical, cardiovascular, reproductive, immunological, and neurobiological consequences. Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sapolsky, Robert M -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):648-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305-5020, USA. sapolsky@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety ; Behavior, Animal ; Cardiovascular Physiological Phenomena ; Catecholamines/metabolism ; Dominance-Subordination ; *Health Status ; Humans ; Hydrocortisone/metabolism ; Immune System/physiology ; Nervous System Physiological Phenomena ; *Primates/physiology/psychology ; Reproduction ; *Social Behavior ; Social Class ; *Social Dominance ; *Stress, Physiological/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
    Publication Date: 2005-06-11
    Description: We show that inferences of competence based solely on facial appearance predicted the outcomes of U.S. congressional elections better than chance (e.g., 68.8% of the Senate races in 2004) and also were linearly related to the margin of victory. These inferences were specific to competence and occurred within a 1-second exposure to the faces of the candidates. The findings suggest that rapid, unreflective trait inferences can contribute to voting choices, which are widely assumed to be based primarily on rational and deliberative considerations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todorov, Alexander -- Mandisodza, Anesu N -- Goren, Amir -- Hall, Crystal C -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Princeton University, Princeton, NJ 08544, USA. atodorov@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947187" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Character ; Decision Making ; *Face/anatomy & histology ; Federal Government ; Female ; Forecasting ; Humans ; Intelligence ; Judgment ; Leadership ; Male ; *Mental Competency ; *Politics ; *Social Perception ; Stereotyping ; Trust ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):43-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210515" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autophagy ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Clinical Trials as Topic ; Corpus Striatum/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Huntington Disease/*drug therapy/genetics/pathology/*physiopathology ; Mice ; Mitochondria/metabolism ; Mutation ; Nerve Tissue Proteins/chemistry/*genetics/metabolism/*physiology ; Neurons/*physiology ; Nuclear Proteins/chemistry/*genetics/metabolism/*physiology ; Peptides ; Transcription Factors/metabolism ; Trinucleotide Repeat Expansion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 25
    Publication Date: 2005-02-19
    Description: Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector. The rictor-mTOR complex directly phosphorylated Akt/PKB on Ser473 in vitro and facilitated Thr308 phosphorylation by PDK1. Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sarbassov, D D -- Guertin, David A -- Ali, Siraj M -- Sabatini, David M -- R01 AI47389/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1098-101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718470" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Phosphoinositide-Dependent Protein Kinases ; Adaptor Proteins, Signal Transducing ; Animals ; Carrier Proteins/*metabolism ; Cell Line ; Cell Line, Tumor ; Drosophila Proteins/*metabolism ; Drosophila melanogaster ; Enzyme Activation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Immunoprecipitation ; Phosphatidylinositol 3-Kinases/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Protein-Serine-Threonine Kinases/*metabolism ; Proteins/metabolism ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-akt ; RNA Interference ; Serine/metabolism ; TOR Serine-Threonine Kinases
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1395.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bioterrorism/prevention & control ; Botulinum Toxins ; Food Supply ; Humans ; Milk ; *Periodicals as Topic ; Publishing ; *Retraction of Publication as Topic ; United States ; *United States Dept. of Health and Human Services
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1026.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718436" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Bias (Epidemiology) ; Cohort Studies ; Confounding Factors (Epidemiology) ; Epidemiologic Methods ; Humans ; *Immunization Programs ; *Influenza Vaccines ; Influenza, Human/*mortality/*prevention & control ; United States/epidemiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: Funding bodies are coming to the aid of young scientists with a variety of programs aimed at helping them become independent investigators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forde, Anne -- Pain, Elisabeth -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):427-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831761" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Mobility ; Education, Graduate ; *Faculty ; *Fellowships and Scholarships ; Great Britain ; Humans ; Ireland ; *Research Personnel ; *Research Support as Topic ; Universities
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Inman, Mason -- New York, N.Y. -- Science. 2005 May 13;308(5724):937.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890852" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; *Ecosystem ; Environment ; Fisheries ; *Fishes ; North Sea ; Population Dynamics ; *Seawater ; Temperature
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):864-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081709" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Alzheimer Disease/epidemiology/*prevention & control ; Animals ; Brain/physiology ; Education ; *Exercise ; Female ; Humans ; Life Style ; Male ; *Mental Processes
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  • 31
    Publication Date: 2005-10-29
    Description: Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomlins, Scott A -- Rhodes, Daniel R -- Perner, Sven -- Dhanasekaran, Saravana M -- Mehra, Rohit -- Sun, Xiao-Wei -- Varambally, Sooryanarayana -- Cao, Xuhong -- Tchinda, Joelle -- Kuefer, Rainer -- Lee, Charles -- Montie, James E -- Shah, Rajal B -- Pienta, Kenneth J -- Rubin, Mark A -- Chinnaiyan, Arul M -- 5P30 CA46592/CA/NCI NIH HHS/ -- P50CA69568/CA/NCI NIH HHS/ -- R01 CA97063/CA/NCI NIH HHS/ -- R01AG21404/AG/NIA NIH HHS/ -- UO1 CA111275-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):644-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254181" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/*genetics ; Gene Expression Regulation, Neoplastic ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Neoplasm Proteins/*genetics ; Oncogene Proteins, Fusion/*genetics ; Polymerase Chain Reaction ; Prostatic Neoplasms/*genetics ; Serine Endopeptidases/*genetics ; Trans-Activators/*genetics ; Transcription Factors/*genetics ; Translocation, Genetic
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  • 32
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1851.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790813" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Energy Metabolism ; Female ; Fraud ; History, 20th Century ; History, 21st Century ; Humans ; Menopause ; *National Institutes of Health (U.S.) ; *Publishing ; *Research Support as Topic ; Retraction of Publication as Topic ; *Scientific Misconduct ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawa, Akira -- Snyder, Solomon H -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1128-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. asawa1@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293746" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/physiology ; Affective Disorders, Psychotic/enzymology/*genetics ; Carrier Proteins/physiology ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Humans ; Mutation ; Nerve Tissue Proteins/*genetics/physiology ; Protein Binding ; Schizophrenia/*genetics ; Signal Transduction ; Translocation, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):23-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637239" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group/genetics ; Chemokines, CC/*genetics ; European Continental Ancestry Group/genetics ; *Gene Dosage ; Gene Duplication ; *Genetic Predisposition to Disease ; HIV Infections/*genetics ; Humans
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  • 35
    Publication Date: 2005-07-26
    Description: Land use has generally been considered a local environmental issue, but it is becoming a force of global importance. Worldwide changes to forests, farmlands, waterways, and air are being driven by the need to provide food, fiber, water, and shelter to more than six billion people. Global croplands, pastures, plantations, and urban areas have expanded in recent decades, accompanied by large increases in energy, water, and fertilizer consumption, along with considerable losses of biodiversity. Such changes in land use have enabled humans to appropriate an increasing share of the planet's resources, but they also potentially undermine the capacity of ecosystems to sustain food production, maintain freshwater and forest resources, regulate climate and air quality, and ameliorate infectious diseases. We face the challenge of managing trade-offs between immediate human needs and maintaining the capacity of the biosphere to provide goods and services in the long term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foley, Jonathan A -- Defries, Ruth -- Asner, Gregory P -- Barford, Carol -- Bonan, Gordon -- Carpenter, Stephen R -- Chapin, F Stuart -- Coe, Michael T -- Daily, Gretchen C -- Gibbs, Holly K -- Helkowski, Joseph H -- Holloway, Tracey -- Howard, Erica A -- Kucharik, Christopher J -- Monfreda, Chad -- Patz, Jonathan A -- Prentice, I Colin -- Ramankutty, Navin -- Snyder, Peter K -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):570-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Sustainability and the Global Environment (SAGE), University of Wisconsin, 1710 University Avenue, Madison, WI 53726, USA. jfoley@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040698" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Air Pollution ; Animals ; Animals, Wild ; Climate ; Communicable Diseases/epidemiology/transmission ; *Conservation of Natural Resources ; *Ecosystem ; *Environment ; Fresh Water ; Human Activities ; Humans ; Policy Making ; Trees
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):836-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705823" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Division ; Cell Nucleus/*metabolism ; Centromere/physiology ; Chromosome Segregation ; DNA Repair ; GTPase-Activating Proteins/metabolism ; Gene Expression Regulation ; Humans ; Molecular Chaperones ; Neurodegenerative Diseases/metabolism ; Nuclear Pore Complex Proteins/metabolism ; Proteins/*metabolism ; Small Ubiquitin-Related Modifier Proteins/chemistry/*physiology ; Spindle Apparatus/metabolism ; Transcription Factors/*metabolism ; Viral Proteins/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: Large numbers of noncoding RNA transcripts (ncRNAs) are being revealed by complementary DNA cloning and genome tiling array studies in animals. The big and as yet largely unanswered question is whether these transcripts are relevant. A paper by Willingham et al. shows the way forward by developing a strategy for large-scale functional screening of ncRNAs, involving small interfering RNA knockdowns in cell-based screens, which identified a previously unidentified ncRNA repressor of the transcription factor NFAT. It appears likely that ncRNAs constitute a critical hidden layer of gene regulation in complex organisms, the understanding of which requires new approaches in functional genomics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mattick, John S -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1527-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. j.mattick@imb.uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141063" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Conserved Sequence ; DNA-Binding Proteins/antagonists & inhibitors ; *Genomics ; Humans ; Mice ; NFATC Transcription Factors ; Nuclear Proteins/antagonists & inhibitors ; *RNA Interference ; RNA, Untranslated/antagonists & inhibitors/genetics/*physiology ; Transcription Factors/antagonists & inhibitors ; beta Karyopherins/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1890-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373546" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Aspirin/therapeutic use ; Celecoxib ; Confounding Factors (Epidemiology) ; Cyclooxygenase 1 ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Cyclooxygenase Inhibitors/adverse effects/*therapeutic use ; Drug Interactions ; Heart Diseases/*drug therapy ; Humans ; Ibuprofen/therapeutic use ; Membrane Proteins/antagonists & inhibitors ; Naproxen/therapeutic use ; Pyrazoles/adverse effects/*therapeutic use ; Randomized Controlled Trials as Topic/ethics/methods/standards ; *Research Design ; Sulfonamides/adverse effects/*therapeutic use
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254155" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; Genomics ; *Haplotypes ; Humans
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  • 40
    Publication Date: 2005-12-17
    Description: Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols). These domains are required for binding of poleta and poliota to ubiquitin, their accumulation in replication factories, and their interaction with monoubiquitinated PCNA. Moreover, the UBZ domain of poleta is essential to efficiently restore a normal response to ultraviolet irradiation in xeroderma pigmentosum variant (XP-V) fibroblasts. Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bienko, Marzena -- Green, Catherine M -- Crosetto, Nicola -- Rudolf, Fabian -- Zapart, Grzegorz -- Coull, Barry -- Kannouche, Patricia -- Wider, Gerhard -- Peter, Matthias -- Lehmann, Alan R -- Hofmann, Kay -- Dikic, Ivan -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Cell Line ; Computational Biology ; DNA/*biosynthesis ; *DNA Damage ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/*chemistry/genetics/*metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Point Mutation ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/metabolism ; Transfection ; Ubiquitin/*metabolism ; Xeroderma Pigmentosum/genetics ; Zinc Fingers
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1665.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16150988" target="_blank"〉PubMed〈/a〉
    Keywords: Breast/*anatomy & histology ; Breast Neoplasms/etiology ; Female ; Humans ; *Mammography ; Risk Factors ; *Software
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):684-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051760" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Blood Specimen Collection ; *Dna ; *Databases, Genetic ; Genetic Privacy ; Humans ; *Medical Records Systems, Computerized ; New York ; United States ; *United States Department of Veterans Affairs ; *Universities ; *Veterans
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):83.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994529" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Caloric Restriction ; Forecasting ; Humans ; Insulin-Like Growth Factor I/metabolism ; *Life Expectancy/trends ; *Longevity ; Oxidative Stress
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kone-Cni, Vladimir J -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793900" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; *Prisoners ; *Psychology, Social ; *Torture ; United States ; Warfare
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):728.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticholesteremic Agents/therapeutic use ; *Biomedical Research/economics ; *Chemistry, Pharmaceutical/economics ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry/economics ; Humans ; *Research Personnel/economics ; *Technology, Pharmaceutical/economics
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  • 46
    Publication Date: 2005-10-29
    Description: Global change will alter the supply of ecosystem services that are vital for human well-being. To investigate ecosystem service supply during the 21st century, we used a range of ecosystem models and scenarios of climate and land-use change to conduct a Europe-wide assessment. Large changes in climate and land use typically resulted in large changes in ecosystem service supply. Some of these trends may be positive (for example, increases in forest area and productivity) or offer opportunities (for example, "surplus land" for agricultural extensification and bioenergy production). However, many changes increase vulnerability as a result of a decreasing supply of ecosystem services (for example, declining soil fertility, declining water availability, increasing risk of forest fires), especially in the Mediterranean and mountain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schroter, Dagmar -- Cramer, Wolfgang -- Leemans, Rik -- Prentice, I Colin -- Araujo, Miguel B -- Arnell, Nigel W -- Bondeau, Alberte -- Bugmann, Harald -- Carter, Timothy R -- Gracia, Carlos A -- de la Vega-Leinert, Anne C -- Erhard, Markus -- Ewert, Frank -- Glendining, Margaret -- House, Joanna I -- Kankaanpaa, Susanna -- Klein, Richard J T -- Lavorel, Sandra -- Lindner, Marcus -- Metzger, Marc J -- Meyer, Jeannette -- Mitchell, Timothy D -- Reginster, Isabelle -- Rounsevell, Mark -- Sabate, Santi -- Sitch, Stephen -- Smith, Ben -- Smith, Jo -- Smith, Pete -- Sykes, Martin T -- Thonicke, Kirsten -- Thuiller, Wilfried -- Tuck, Gill -- Zaehle, Sonke -- Zierl, Barbel -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1333-7. Epub 2005 Oct 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany. dagmar.schroeter@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254151" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Biodiversity ; Carbon ; Climate ; Conservation of Natural Resources ; Crops, Agricultural ; *Ecosystem ; Environment ; Europe ; Greenhouse Effect ; Humans ; Models, Statistical ; Models, Theoretical ; Socioeconomic Factors ; Trees/growth & development ; Urban Population ; Water Supply ; Wood
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, Anthony G -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):208-9; author reply 208-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662728" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; Diet ; Edible Grain/chemistry ; Fatty Acids, Unsaturated/analysis ; Humans ; *Inflammation ; *Longevity ; Myocardial Infarction/etiology ; *Nutritional Physiological Phenomena ; Resorcinols/analysis ; Thromboxane A2/metabolism
    Print ISSN: 0036-8075
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1410-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322433" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; Geography ; Humans ; *Pest Control
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  • 49
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):962-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284156" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Consciousness ; Great Britain ; History, 20th Century ; History, 21st Century ; Humans ; Neurosciences/*history ; Pain Threshold ; Politics ; Religion
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731414" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Cardiovascular Diseases/chemically induced/epidemiology ; Celecoxib ; Cyclooxygenase Inhibitors/*adverse effects/*therapeutic use ; *Drug Labeling ; Drug and Narcotic Control ; Humans ; Isoxazoles/adverse effects/therapeutic use ; Lactones/adverse effects/therapeutic use ; Pyrazoles/adverse effects/therapeutic use ; Stroke/chemically induced/epidemiology ; Sulfonamides/adverse effects/therapeutic use ; Sulfones/adverse effects/therapeutic use ; United States ; *United States Food and Drug Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1883.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373542" target="_blank"〉PubMed〈/a〉
    Keywords: *Disaster Planning/economics ; *Disasters ; Humans
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  • 52
    Publication Date: 2005-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16223999" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Simulation ; Crowding ; Disaster Planning ; Escape Reaction ; *Facility Design and Construction ; Humans ; *Safety Management ; September 11 Terrorist Attacks
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Dianhua -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363028" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2149.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195437" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Biomedical Research ; Female ; Humans ; Male ; *National Institutes of Health (U.S.) ; *Research Personnel ; United States ; *Women
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  • 55
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845823" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthropology, Physical ; Climate ; Emigration and Immigration ; England ; History, Ancient ; *Hominidae ; Humans ; *Paleontology ; Population Dynamics ; Time
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kueppers, Lara M -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1278-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311318" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Developing Countries ; Humans ; *Models, Theoretical
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  • 57
    Publication Date: 2005-07-16
    Description: Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect in cellular proliferation, but was correlated with the induction of apoptotic markers, particularly in tissues characterized by rapid cellular turnover. The levels of apoptotic markers were also found to increase during aging in normal mice. Thus, accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kujoth, G C -- Hiona, A -- Pugh, T D -- Someya, S -- Panzer, K -- Wohlgemuth, S E -- Hofer, T -- Seo, A Y -- Sullivan, R -- Jobling, W A -- Morrow, J D -- Van Remmen, H -- Sedivy, J M -- Yamasoba, T -- Tanokura, M -- Weindruch, R -- Leeuwenburgh, C -- Prolla, T A -- AG021905/AG/NIA NIH HHS/ -- AG16694/AG/NIA NIH HHS/ -- AG17994/AG/NIA NIH HHS/ -- AG18922/AG/NIA NIH HHS/ -- AG21042/AG/NIA NIH HHS/ -- DK48831/DK/NIDDK NIH HHS/ -- RR00095/RR/NCRR NIH HHS/ -- T32 AG00213/AG/NIA NIH HHS/ -- T32 GM07601/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):481-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020738" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Amino Acid Substitution ; Animals ; *Apoptosis ; Caspase 3 ; Caspases/metabolism ; Cloning, Molecular ; DNA Damage ; DNA Fragmentation ; DNA, Mitochondrial/*genetics ; DNA-Directed DNA Polymerase/genetics ; Gene Targeting ; Humans ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation ; Liver/metabolism ; Mice ; Mitochondria, Heart/metabolism ; Mitochondria, Liver/metabolism ; Muscle, Skeletal/metabolism ; *Mutation ; Myocardium/metabolism ; *Oxidative Stress ; Phenotype ; Presbycusis/etiology ; Reactive Oxygen Species/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1595.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339414" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/standards ; *Cell Line ; *Cloning, Organism ; Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; *Publishing ; *Stem Cells
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):334.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831722" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/administration & dosage/adverse effects/*therapeutic use ; *Clinical Trials as Topic/standards ; Female ; HIV Infections/drug therapy/*prevention & control/*transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Institute of Medicine (U.S.) ; National Institutes of Health (U.S.) ; Nevirapine/administration & dosage/adverse effects/*therapeutic use ; Pilot Projects ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Uganda ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jorde, Lynn B -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):60-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. lbj@genetics.utah.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802591" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Alleles ; Animals ; Chromosome Mapping ; Chromosomes, Human/genetics ; Chromosomes, Mammalian/genetics ; Evolution, Molecular ; *Genome ; *Genome, Human ; Haplotypes ; Humans ; Linkage Disequilibrium ; Pan troglodytes/*genetics ; *Recombination, Genetic ; Sample Size ; Sequence Homology, Nucleic Acid
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  • 61
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kraus, Scott D -- Brown, Moira W -- Caswell, Hal -- Clark, Christopher W -- Fujiwara, Masami -- Hamilton, Philip K -- Kenney, Robert D -- Knowlton, Amy R -- Landry, Scott -- Mayo, Charles A -- McLellan, William A -- Moore, Michael J -- Nowacek, Douglas P -- Pabst, D Ann -- Read, Andrew J -- Rolland, Rosalind M -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):561-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Edgerton Research Laboratory, New England Aquarium, Boston, MA 02110-3399, USA. skraus@neaq.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040692" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Ecology ; *Ecosystem ; Environment ; Female ; Fisheries ; Male ; Mortality ; Population Dynamics ; Population Growth ; Public Policy ; Reproduction ; Ships ; *Whales/physiology
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  • 62
    Publication Date: 2005-08-27
    Description: CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peng, Guangyong -- Guo, Zhong -- Kiniwa, Yukiko -- Voo, Kui Shin -- Peng, Weiyi -- Fu, Tihui -- Wang, Daniel Y -- Li, Yanchun -- Wang, Helen Y -- Wang, Rong-Fu -- P01CA94237/CA/NCI NIH HHS/ -- P50 CA093459/CA/NCI NIH HHS/ -- P50CA58204/CA/NCI NIH HHS/ -- R01CA101795/CA/NCI NIH HHS/ -- R01CA90327/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1380-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123302" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Adoptive Transfer ; Animals ; Antigens, Differentiation/genetics/physiology ; CD4-Positive T-Lymphocytes/*immunology ; Cell Line ; Cell Line, Tumor ; Humans ; Immune Tolerance ; Interleukin-1 Receptor-Associated Kinases ; Killer Cells, Natural/immunology ; Ligands ; Lymphocyte Activation ; Membrane Glycoproteins/genetics/*physiology ; Mice ; Myeloid Differentiation Factor 88 ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology/pathology ; Oligodeoxyribonucleotides/immunology ; Phosphotransferases (Alcohol Group Acceptor)/genetics/physiology ; Poly G/immunology ; RNA Interference ; Receptors, Cell Surface/genetics/*physiology ; Receptors, Immunologic/genetics/physiology ; *Signal Transduction ; T-Lymphocyte Subsets/*immunology ; Toll-Like Receptor 8 ; Toll-Like Receptors
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  • 63
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845824" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; *Anthropology, Physical ; Asia ; Chromosomes, Human, X/*genetics ; *Genes ; Genetic Variation ; Genetics, Population ; Haplotypes ; Hominidae/*genetics ; Humans ; Hybridization, Genetic ; Sequence Analysis, DNA ; X Chromosome/*genetics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1401-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Computer Simulation ; Dna ; Evolution, Molecular ; *Genome ; Humans ; Mammals/genetics ; Species Specificity
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):551-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/physiology ; Circadian Rhythm ; Female ; Gonadotropin-Releasing Hormone/physiology/secretion ; Humans ; Hypogonadism/genetics ; Kisspeptins ; Leptin/genetics/physiology ; Male ; Mutation ; Neurons/physiology ; Proteins/genetics/*physiology ; Puberty/*physiology ; Receptors, Cell Surface/genetics/metabolism ; Receptors, G-Protein-Coupled ; Receptors, Leptin ; Receptors, Neuropeptide/genetics/*physiology ; Reproduction ; Signal Transduction ; Tumor Suppressor Proteins
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  • 66
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339426" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Environment ; Financing, Government ; Great Britain ; Humans ; International Cooperation ; Nanostructures/*toxicity ; *Nanotechnology ; Occupational Exposure ; *Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339425" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*pharmacology ; Artemisinins/*pharmacology/therapeutic use ; Cambodia ; Cost-Benefit Analysis ; Drug Resistance ; Drug Therapy, Combination ; French Guiana ; Humans ; Malaria/drug therapy/parasitology ; Plasmodium/*drug effects ; Senegal
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Christopher N -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):255-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia. christopher.johnson@jcu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16002607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthropology ; Australia ; *Birds ; Carbon Isotopes ; Climate ; *Diet ; Dromaiidae ; *Ecosystem ; *Environment ; *Food Chain ; Humans ; *Mammals ; Marsupialia ; *Plants ; Poaceae ; Population Dynamics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821057" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism/*legislation & jurisprudence ; Capital Punishment ; Child ; Foreign Professional Personnel/*legislation & jurisprudence ; HIV Infections/*transmission ; Humans ; Libya ; Medical Staff/*legislation & jurisprudence ; Politics
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Ian T -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1839.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790809" target="_blank"〉PubMed〈/a〉
    Keywords: Anticarcinogenic Agents/administration & dosage ; Developed Countries ; *Diet ; Gastrointestinal Neoplasms/*etiology/prevention & control ; Humans ; Inflammation ; Overnutrition
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821056" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Acquired Immunodeficiency Syndrome/epidemiology ; Biomedical Research/economics/legislation & jurisprudence/trends ; Crime/*legislation & jurisprudence ; Emigration and Immigration/legislation & jurisprudence ; Government Agencies ; Humans ; Libya/epidemiology ; Medical Staff ; Research/economics/legislation & jurisprudence/*trends
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):721.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051780" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Pharmaceutical ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry ; Humans ; *Pharmaceutical Preparations ; Technology, Pharmaceutical
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuo, Arthur D -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1686-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Mechanical Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA. artkuo@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151001" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioelectric Energy Sources ; Biomechanical Phenomena ; *Electricity ; *Energy Metabolism ; Humans ; *Walking ; Weight-Bearing
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):602.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Proliferation/*drug effects ; Ciliary Neurotrophic Factor/*pharmacology ; Humans ; Hypothalamus/cytology/*drug effects ; Mice ; Neurons/cytology/*drug effects ; Weight Loss/*drug effects
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  • 75
    Publication Date: 2005-05-21
    Description: Gene marking with replication-defective retroviral vectors has been used for more than 20 years to track the in vivo fate of cell clones. We demonstrate that retroviral integrations themselves may trigger nonmalignant clonal expansion in murine long-term hematopoiesis. All 29 insertions recovered from clones dominating in serially transplanted recipients affected loci with an established or potential role in the self-renewal or survival of hematopoietic stem cells. Transcriptional dysregulation occurred in all 12 insertion sites analyzed. These findings have major implications for diagnostic gene marking and the discovery of genes regulating stem cell turnover.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kustikova, Olga -- Fehse, Boris -- Modlich, Ute -- Yang, Min -- Dullmann, Jochen -- Kamino, Kenji -- von Neuhoff, Nils -- Schlegelberger, Brigitte -- Li, Zhixiong -- Baum, Christopher -- New York, N.Y. -- Science. 2005 May 20;308(5725):1171-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone Marrow Transplantation, University Hospital Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905401" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD34/genetics ; Bone Marrow Transplantation ; DNA-Binding Proteins/genetics ; Down-Regulation ; *Genetic Vectors ; *Hematopoiesis ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*physiology ; Humans ; Ligase Chain Reaction ; Mice ; Mice, Inbred C57BL ; *Mutagenesis, Insertional ; Polymerase Chain Reaction ; Proto-Oncogenes/genetics ; Retroviridae/*genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transgenes ; Up-Regulation ; *Virus Integration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/cytology ; *Cell Line ; Embryo Implantation ; Embryo Research/economics/*ethics ; Embryo, Mammalian/*cytology ; Female ; Financing, Government ; Humans ; Mice ; Nuclear Transfer Techniques ; *Pluripotent Stem Cells ; Research Support as Topic ; *Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosch, Xavier -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166486" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Child ; *Clinical Trials as Topic ; *Drug Approval ; *European Union ; Humans ; *Legislation, Drug ; *Pediatrics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Evolution, Molecular ; *Genome ; *Genome, Human ; Genomics ; Humans ; Pan troglodytes/*genetics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Cooperative Behavior ; Game Theory ; Humans ; Memory ; Social Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994526" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Chromatin/physiology ; *Gene Expression Regulation ; *Genes ; *Genome, Human ; Humans ; RNA, Untranslated/genetics/physiology ; Regulatory Sequences, Nucleic Acid
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1753.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357233" target="_blank"〉PubMed〈/a〉
    Keywords: *Academic Medical Centers/economics/manpower ; Budgets ; *Disasters ; *Faculty ; Humans ; Louisiana ; *Personnel Downsizing ; *Schools, Medical/economics/manpower ; *Universities/economics/manpower
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1179.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731410" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Size ; Bone and Bones/*chemistry ; DNA/*chemistry ; *Fossils ; History, Ancient ; *Hominidae/anatomy & histology/classification/genetics ; Humans ; Indonesia ; Microcephaly/history ; Ribs ; *Sequence Analysis, DNA ; Skeleton
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradford, Barry -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994508" target="_blank"〉PubMed〈/a〉
    Keywords: Beginning of Human Life ; Christianity ; Embryo Research/*ethics ; Humans ; *Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):85.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Division ; Cell Nucleus/physiology ; Cloning, Organism ; Cues ; Embryo, Mammalian/cytology ; Forecasting ; *Gene Expression Regulation ; Humans ; Nuclear Transfer Techniques ; Oocytes/cytology/*physiology ; Stem Cells/cytology/*physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):841.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705826" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Mitochondrial/analysis ; Female ; Fossils ; Hominidae/classification/*genetics ; Humans ; *Hybridization, Genetic ; Male ; *Sexual Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):755.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272086" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Anti-Infective Agents ; *Bioterrorism ; Communicable Diseases/drug therapy ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services/*legislation & ; jurisprudence/*organization & administration ; *Vaccines
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790840" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiosis ; Archaea/genetics/*isolation & purification ; Bacteria/genetics/growth & development/*isolation & purification/metabolism ; Bacterial Infections/*microbiology ; Biofilms/growth & development ; Ecosystem ; Genes, Archaeal ; Genes, Bacterial ; Gingiva/microbiology ; Halitosis/microbiology ; Humans ; Mouth/*microbiology ; Mouth Diseases/*microbiology ; Mouthwashes ; Sequence Analysis, DNA ; Tongue/microbiology ; Tooth/microbiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brauer, Jurgen -- New York, N.Y. -- Science. 2005 May 6;308(5723):791-2; author reply 791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources ; *Economics ; Humans
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  • 89
    Publication Date: 2005-11-19
    Description: The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3',5'-monophosphate (cAMP), a second messenger implicated in learning, memory, and mood. We show that DISC1 interacts with the UCR2 domain of PDE4B and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and an increase in PDE4B activity. We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millar, J Kirsty -- Pickard, Benjamin S -- Mackie, Shaun -- James, Rachel -- Christie, Sheila -- Buchanan, Sebastienne R -- Malloy, M Pat -- Chubb, Jennifer E -- Huston, Elaine -- Baillie, George S -- Thomson, Pippa A -- Hill, Elaine V -- Brandon, Nicholas J -- Rain, Jean-Christophe -- Camargo, L Miguel -- Whiting, Paul J -- Houslay, Miles D -- Blackwood, Douglas H R -- Muir, Walter J -- Porteous, David J -- G8604010/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1187-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK. Kirsty.Millar@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293762" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/metabolism ; Adult ; Affective Disorders, Psychotic/genetics/metabolism ; Animals ; Cadherins/genetics ; Cell Line ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 16 ; Cyclic AMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Genetic Predisposition to Disease ; Humans ; Male ; Nerve Tissue Proteins/*genetics/metabolism ; Protein Binding ; Rats ; Schizophrenia/enzymology/*genetics/metabolism ; *Signal Transduction ; Translocation, Genetic
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  • 90
    Publication Date: 2005-12-17
    Description: Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamason, Rebecca L -- Mohideen, Manzoor-Ali P K -- Mest, Jason R -- Wong, Andrew C -- Norton, Heather L -- Aros, Michele C -- Jurynec, Michael J -- Mao, Xianyun -- Humphreville, Vanessa R -- Humbert, Jasper E -- Sinha, Soniya -- Moore, Jessica L -- Jagadeeswaran, Pudur -- Zhao, Wei -- Ning, Gang -- Makalowska, Izabela -- McKeigue, Paul M -- O'donnell, David -- Kittles, Rick -- Parra, Esteban J -- Mangini, Nancy J -- Grunwald, David J -- Shriver, Mark D -- Canfield, Victor A -- Cheng, Keith C -- CA73935/CA/NCI NIH HHS/ -- EY11308/EY/NEI NIH HHS/ -- HD37572/HD/NICHD NIH HHS/ -- HD40179/HD/NICHD NIH HHS/ -- HG002154/HG/NHGRI NIH HHS/ -- HL077910/HL/NHLBI NIH HHS/ -- RR017441/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1782-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357253" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; African Continental Ancestry Group/genetics ; Alanine/genetics ; Alleles ; Amino Acid Sequence ; Animals ; Antiporters/chemistry/*genetics/physiology ; Asian Continental Ancestry Group/genetics ; Biological Evolution ; Calcium/metabolism ; European Continental Ancestry Group/genetics ; Gene Frequency ; Genes ; Genetic Variation ; Haplotypes ; Heterozygote ; Humans ; Ion Transport ; Melanins/analysis ; Melanosomes/chemistry/ultrastructure ; Mice ; Molecular Sequence Data ; Multifactorial Inheritance ; Mutation ; Pigment Epithelium of Eye/chemistry/ultrastructure ; Polymorphism, Single Nucleotide ; Selection, Genetic ; Skin Pigmentation/*genetics ; Threonine/genetics ; Zebrafish/embryology/*genetics/metabolism ; Zebrafish Proteins/chemistry/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):952-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284148" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*supply & distribution ; Cell Line ; *Disease Outbreaks/prevention & control ; Financing, Government ; Humans ; Influenza A Virus, H5N1 Subtype/growth & development/immunology/pathogenicity ; Influenza A virus/growth & development/immunology ; Influenza Vaccines/*economics ; Influenza, Human/drug therapy/*epidemiology/prevention & control/*virology ; United States ; Virus Cultivation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210501" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Bioterrorism ; Chick Embryo/virology ; Containment of Biohazards ; Disease Outbreaks/history ; Editorial Policies ; *Genes, Viral ; Genome, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; History, 20th Century ; Humans ; Influenza A virus/*genetics/*pathogenicity/physiology ; Influenza, Human/epidemiology/history/*virology ; Mice ; Neuraminidase/genetics/metabolism ; Publishing ; RNA Replicase/genetics/metabolism ; United States ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Russell -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2007-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Auckland, Auckland 92019, New Zealand. rd.gray@auckland.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179464" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; *Cultural Evolution ; Databases, Factual ; History, Ancient ; Humans ; *Language ; *Linguistics ; Pacific Islands ; Papua New Guinea ; Software ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):345.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661989" target="_blank"〉PubMed〈/a〉
    Keywords: *Communicable Disease Control ; Communicable Diseases/diagnosis ; *Disasters ; *Disease Notification ; Disease Outbreaks/*prevention & control ; Epidemiologic Methods ; Humans ; India ; Indian Ocean ; Indonesia ; *Population Surveillance ; Relief Work ; Sri Lanka ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
    Publication Date: 2005-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greene, Mark -- Schill, Kathryn -- Takahashi, Shoji -- Bateman-House, Alison -- Beauchamp, Tom -- Bok, Hilary -- Cheney, Dorothy -- Coyle, Joseph -- Deacon, Terrence -- Dennett, Daniel -- Donovan, Peter -- Flanagan, Owen -- Goldman, Steven -- Greely, Henry -- Martin, Lee -- Miller, Earl -- Mueller, Dawn -- Siegel, Andrew -- Solter, Davor -- Gearhart, John -- McKhann, Guy -- Faden, Ruth -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):385-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Philosophy, University of Delaware, Newark, DE 19716, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020716" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Experimentation/*ethics ; Animals ; Brain/anatomy & histology/physiology ; Cell Line ; *Ethics, Research ; Humans ; Mental Processes ; Moral Obligations ; *Morals ; Neurons/cytology/physiology/*transplantation ; *Primates/psychology ; Stem Cell Transplantation/*ethics ; Transplantation Chimera ; Transplantation, Heterologous/*ethics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933166" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen Antagonists/*toxicity ; Animals ; Endocrine Glands/*drug effects ; Environmental Pollutants/toxicity ; Epigenesis, Genetic/drug effects ; Female ; Fertility/*drug effects/genetics ; Humans ; Infertility, Male/chemically induced/genetics ; Inheritance Patterns ; Insecticides/*toxicity ; Male ; Methoxychlor/*toxicity ; Oxazoles/*toxicity ; Pregnancy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persaud, Raj -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793899" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; Military Personnel/*psychology ; Politics ; *Prisoners ; *Psychology, Social ; Torture/*psychology ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2005-01-18
    Description: Amyloid fibrils commonly exhibit multiple distinct morphologies in electron microscope and atomic force microscope images, often within a single image field. By using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue beta-amyloid peptide of Alzheimer's disease (Abeta(1-40)), we show that different fibril morphologies have different underlying molecular structures, that the predominant structure can be controlled by subtle variations in fibril growth conditions, and that both morphology and molecular structure are self-propagating when fibrils grow from preformed seeds. Different Abeta(1-40) fibril morphologies also have significantly different toxicities in neuronal cell cultures. These results have implications for the mechanism of amyloid formation, the phenomenon of strains in prion diseases, the role of amyloid fibrils in amyloid diseases, and the development of amyloid-based nano-materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petkova, Aneta T -- Leapman, Richard D -- Guo, Zhihong -- Yau, Wai-Ming -- Mattson, Mark P -- Tycko, Robert -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):262-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, MD 20892-0520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653506" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amyloid beta-Peptides/*chemistry/toxicity/*ultrastructure ; Animals ; Cells, Cultured ; Chemistry, Physical ; Hippocampus/cytology ; Humans ; Hydrogen Bonding ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; Molecular Structure ; Neurons/cytology/drug effects ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/*chemistry/toxicity/*ultrastructure ; Physicochemical Phenomena ; Protein Conformation ; Protein Structure, Secondary ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Timothy M -- Cleveland, Don W -- R37 NS027036/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):361-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research and the Department of Medicine and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661995" target="_blank"〉PubMed〈/a〉
    Keywords: Amyotrophic Lateral Sclerosis/*drug therapy ; Animals ; Anti-Bacterial Agents/pharmacology/*therapeutic use ; Brain/metabolism ; Ceftriaxone/pharmacology/*therapeutic use ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Excitatory Amino Acid Transporter 2/genetics/metabolism ; Glutamic Acid/metabolism ; Humans ; Mice ; Motor Neurons/physiology ; Neurodegenerative Diseases/*drug therapy ; Spinal Cord/metabolism ; Synapses/physiology ; Synaptic Transmission ; beta-Lactams/pharmacology/*therapeutic use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2005-12-03
    Description: Proper chromosome segregation requires the attachment of sister kinetochores to microtubules from opposite spindle poles to form bi-oriented chromosomes on the metaphase spindle. The chromosome passenger complex containing Survivin and the kinase Aurora B regulates this process from the centromeres. We report that a de-ubiquitinating enzyme, hFAM, regulates chromosome alignment and segregation by controlling both the dynamic association of Survivin with centromeres and the proper targeting of Survivin and Aurora B to centromeres. Survivin is ubiquitinated in mitosis through both Lys(48) and Lys(63) ubiquitin linkages. Lys(63) de-ubiquitination mediated by hFAM is required for the dissociation of Survivin from centromeres, whereas Lys(63) ubiquitination mediated by the ubiquitin binding protein Ufd1 is required for the association of Survivin with centromeres. Thus, ubiquitinaton regulates dynamic protein-protein interactions and chromosome segregation independently of protein degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vong, Queenie P -- Cao, Kan -- Li, Hoi Y -- Iglesias, Pablo A -- Zheng, Yixian -- GM56312/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1499-504.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, 3520 San Martin Drive, Baltimore, MD 21218, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322459" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Aurora Kinase B ; Aurora Kinases ; Centromere/*metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Segregation/*physiology ; Egg Proteins/metabolism ; Endopeptidases/metabolism ; HeLa Cells ; Humans ; Inhibitor of Apoptosis Proteins ; Lysine/metabolism ; Microtubule-Associated Proteins/metabolism ; Molecular Sequence Data ; Neoplasm Proteins/metabolism ; Protein Binding ; Protein-Serine-Threonine Kinases/metabolism ; Ubiquitin/*metabolism ; Ubiquitin Thiolesterase ; Xenopus ; Xenopus Proteins/*metabolism
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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