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  • Articles  (81)
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  • 2000-2004  (81)
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  • 2002  (81)
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  • Articles  (81)
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  • 2000-2004  (81)
  • 1995-1999
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  • 1
    Publication Date: 2002-11-02
    Description: The interaction of climate and the timing of low tides along the West Coast of the United States creates a complex mosaic of thermal environments, in which northern sites can be more thermally stressful than southern sites. Thus, climate change may not lead to a poleward shift in the distribution of intertidal organisms, as has been proposed, but instead will likely cause localized extinctions at a series of "hot spots." Patterns of exposure to extreme climatic conditions are temporally variable, and tidal predictions suggest that in the next 3 to 5 years "hot spots" are likely to appear at several northern sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helmuth, Brian -- Harley, Christopher D G -- Halpin, Patricia M -- O'Donnell, Michael -- Hofmann, Gretchen E -- Blanchette, Carol A -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1015-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of South Carolina, Department of Biological Sciences and Marine Sciences Program, Columbia, SC 29208, USA. helmuth@biol.sc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411702" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bivalvia/*physiology ; *Body Temperature ; *Climate ; *Ecosystem ; Environment ; Geography ; Pacific Ocean ; Pacific States ; Seasons ; *Seawater ; Temperature ; *Water Movements
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winograd, Isaac J -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):7 discussion 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Geological Survey, 432 National Center, 12201 Sunrise Valley Drive, Reston, VA 20192, USA. ijwinogr@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934990" target="_blank"〉PubMed〈/a〉
    Keywords: California ; *Climate ; Geologic Sediments ; Ice ; Nevada ; Oceans and Seas ; Oxygen Isotopes ; Seawater ; Temperature ; Time
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schrag, Daniel P -- Linsley, Braddock K -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):277-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Geochemical Oceanography, Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA 02138, USA. schrag@eps.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951026" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/analysis ; Calcium Carbonate/*chemistry ; Chemical Precipitation ; Climate ; Cnidaria/*chemistry/growth & development/physiology ; Eukaryota/*physiology ; Oceans and Seas ; Photosynthesis ; Seasons ; *Seawater ; Strontium/analysis ; *Symbiosis ; Temperature ; Time ; *Tropical Climate
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2002-06-08
    Description: The inferred crystallographic class of circumstellar silicon carbide based on astronomical infrared spectra is controversial. We have directly determined the polytype distribution of circumstellar SiC from transmission electron microscopy of presolar silicon carbide from the Murchison carbonaceous meteorite. Only two polytypes (of a possible several hundred) were observed: cubic 3C and hexagonal 2H silicon carbide and their intergrowths. We conclude that this structural simplicity is a direct consequence of the low pressures in circumstellar outflows and the corresponding low silicon carbide condensation temperatures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daulton, T L -- Bernatowicz, T J -- Lewis, R S -- Messenger, S -- Stadermann, F J -- Amari, S -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1852-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials Science Division, Argonne National Laboratory, Argonne IL, 60439-4838, USA. tdaulton@nrlssc.navy.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052956" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomical Phenomena ; *Astronomy ; Carbon Compounds, Inorganic/*analysis ; *Meteoroids ; Microscopy, Electron ; Pressure ; Silicon Compounds/*analysis ; Temperature
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  • 5
    Publication Date: 2002-05-23
    Description: Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peier, Andrea M -- Reeve, Alison J -- Andersson, David A -- Moqrich, Aziz -- Earley, Taryn J -- Hergarden, Anne C -- Story, Gina M -- Colley, Sian -- Hogenesch, John B -- McIntyre, Peter -- Bevan, Stuart -- Patapoutian, Ardem -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2046-9. Epub 2002 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016205" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Newborn ; Blotting, Northern ; CHO Cells ; Capsaicin/*analogs & derivatives/pharmacology ; *Cation Transport Proteins ; Cell Line ; Cells, Cultured ; Cloning, Molecular ; Cricetinae ; Epidermis/cytology/innervation/metabolism ; Ganglia, Spinal/metabolism ; *Hot Temperature ; Humans ; In Situ Hybridization ; Ion Channels/chemistry/genetics/*metabolism ; Keratinocytes/*metabolism ; Membrane Potentials ; Mice ; Molecular Sequence Data ; Nerve Endings/physiology ; Neurons/physiology ; Patch-Clamp Techniques ; RNA, Messenger/genetics/metabolism ; Ruthenium Red/pharmacology ; Signal Transduction ; Spinal Cord/metabolism ; TRPV Cation Channels ; Temperature
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bostanci, Adam -- New York, N.Y. -- Science. 2002 May 10;296(5570):1000-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; *Decapodiformes/physiology ; Falkland Islands ; *Fisheries ; Forecasting ; Models, Biological ; Seawater ; Temperature ; Water Movements
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-01-26
    Description: The pack ice of Earth's polar oceans appears to be frozen white desert, devoid of life. However, beneath the snow lies a unique habitat for a group of bacteria and microscopic plants and animals that are encased in an ice matrix at low temperatures and light levels, with the only liquid being pockets of concentrated brines. Survival in these conditions requires a complex suite of physiological and metabolic adaptations, but sea-ice organisms thrive in the ice, and their prolific growth ensures they play a fundamental role in polar ecosystems. Apart from their ecological importance, the bacterial and algae species found in sea ice have become the focus for novel biotechnology, as well as being considered proxies for possible life forms on ice-covered extraterrestrial bodies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, D N -- Dieckmann, G S -- New York, N.Y. -- Science. 2002 Jan 25;295(5555):641-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Ocean Sciences, University of Wales-Bangor, Menai Bridge, Anglesey, UK, LL59 5EY. d.thomas@bangor.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11809961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; *Bacterial Physiological Phenomena ; Biotechnology ; *Ecosystem ; Environment ; Eukaryota/*physiology ; Exobiology ; Freezing ; *Ice ; Light ; *Seawater/microbiology ; Sodium Chloride ; Temperature ; Ultraviolet Rays
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  • 8
    Publication Date: 2002-10-26
    Description: The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dillin, Andrew -- Crawford, Douglas K -- Kenyon, Cynthia -- 5RO1AG11816/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):830-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399591" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Caenorhabditis elegans/genetics/growth & development/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; DEAD-box RNA Helicases ; Forkhead Transcription Factors ; Insulin/*physiology ; Insulin-Like Growth Factor I/*physiology ; Life Cycle Stages/physiology ; Longevity ; Mutation ; Oxidative Stress ; RNA Helicases/genetics/physiology ; RNA Interference ; Receptor, Insulin/genetics/*physiology ; Reproduction ; *Signal Transduction ; Temperature ; Transcription Factors/genetics/physiology
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  • 9
    Publication Date: 2002-04-27
    Description: The introduction of biodegradable implant materials as well as minimally invasive surgical procedures in medicine has substantially improved health care within the past few decades. This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature. Their shape-memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. A smart degradable suture was created to illustrate the potential of these shape-memory thermoplastics in biomedical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lendlein, Andreas -- Langer, Robert -- New York, N.Y. -- Science. 2002 May 31;296(5573):1673-6. Epub 2002 Apr 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉mnemoScience GmbH, Pauwelsstrabetae 19, D-52074 Aachen, Germany. a.lendlein@mnemoscience.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976407" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocompatible Materials/chemical synthesis/chemistry ; Chemistry, Physical ; Dioxanes/chemistry ; Elasticity ; Elastomers ; Isocyanates/chemistry ; Mechanics ; Physicochemical Phenomena ; Polyesters/chemistry ; *Polymers/chemical synthesis/chemistry ; *Prostheses and Implants ; Rats ; Stress, Mechanical ; *Sutures ; Temperature ; Thermodynamics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hagmann, Michael -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2006-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896256" target="_blank"〉PubMed〈/a〉
    Keywords: Acetic Acid/chemistry ; Amino Acids/chemistry ; Catalysis ; Chemistry, Physical/history ; *Evolution, Chemical ; History, 20th Century ; History, 21st Century ; Iron/chemistry ; Organic Chemicals/chemistry ; *Origin of Life ; Sulfides/chemistry ; Temperature ; Thermodynamics ; United States
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meunier, Bernard -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):270-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse cedex 04, France. bmeunier@lcc-toulouse.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951021" target="_blank"〉PubMed〈/a〉
    Keywords: Biodegradation, Environmental ; Catalysis ; Chlorine Compounds/chemistry ; Chlorophenols/*chemistry ; Dioxins/chemistry ; *Environmental Pollutants ; Ferric Compounds/*chemistry ; Heterocyclic Compounds with 4 or More Rings/*chemistry ; Hydrogen Peroxide/*chemistry ; Ligands ; Oxidation-Reduction ; Pentachlorophenol/*chemistry ; Pressure ; Temperature
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  • 12
    Publication Date: 2002-12-21
    Description: We present the first direct evidence of the presence of an intermediate singlet excited state (Sx) mediating the internal conversion from S2 to S1 in carotenoids. The S2 to Sx transition is extremely fast and is completed within approximately 50 femtoseconds. These results require a reassessment of the energy transfer pathways from carotenoids to chlorophylls in the primary step of photosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cerullo, G -- Polli, D -- Lanzani, G -- De Silvestri, S -- Hashimoto, H -- Cogdell, R J -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2395-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Laboratory for Ultrafast and Ultraintense Optical Science (INFM), Dipartimento di Fisica, Politecnico di Milano, Piazza L. da Vinci 32, 20133 Milano, Italy. giulio.cerullo@fisi.polimi.it〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493917" target="_blank"〉PubMed〈/a〉
    Keywords: Carotenoids/*chemistry/*metabolism ; Chemistry, Physical ; Chlorophyll/chemistry/metabolism ; Cyclohexanes ; Energy Transfer ; *Light ; Photosynthesis ; Physicochemical Phenomena ; Spectrum Analysis ; Temperature ; beta Carotene/*chemistry/*metabolism
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  • 13
    Publication Date: 2002-09-28
    Description: Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in long-term gene silencing. However, a connection between PcG-mediated gene silencing and histone methylation has not been established. Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27). Using chromatin immunoprecipitation assays, we show that H3-K27 methylation colocalizes with, and is dependent on, E(Z) binding at an Ultrabithorax (Ubx) Polycomb response element (PRE), and that this methylation correlates with Ubx repression. Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cao, Ru -- Wang, Liangjun -- Wang, Hengbin -- Xia, Li -- Erdjument-Bromage, Hediye -- Tempst, Paul -- Jones, Richard S -- Zhang, Yi -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1039-43. Epub 2002 Sep 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351676" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/isolation & purification/metabolism ; Cell Cycle Proteins/metabolism ; Chromatin/metabolism ; DNA-Binding Proteins/genetics/metabolism ; Drosophila ; Drosophila Proteins/genetics/*metabolism ; *Gene Silencing ; Genes, Homeobox ; HeLa Cells ; *Histone-Lysine N-Methyltransferase ; Histones/*metabolism ; *Homeodomain Proteins ; Humans ; Lysine/*metabolism ; Methylation ; Methyltransferases/isolation & purification/metabolism ; Nuclear Proteins/metabolism ; Nucleosomes/metabolism ; Peptide Mapping ; Polycomb Repressive Complex 1 ; Polycomb Repressive Complex 2 ; Precipitin Tests ; Protein Methyltransferases ; Proteins/isolation & purification/metabolism ; RNA Interference ; Repressor Proteins/isolation & purification/metabolism ; Response Elements ; Temperature ; *Transcription Factors
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morgan, Jack A -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1903-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉USDA-ARS Rangeland Resources Research Unit, 1701 Centre Avenue, Fort Collins, CO 80526, USA. morgan@lamar.colostate.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471239" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; California ; *Carbon Dioxide/metabolism ; Climate ; *Ecosystem ; Photosynthesis ; Poaceae/*growth & development/metabolism ; Soil ; Temperature
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  • 15
    Publication Date: 2002-05-23
    Description: Lymphocyte motility is vital for trafficking within lymphoid organs and for initiating contact with antigen-presenting cells. Visualization of these processes has previously been limited to in vitro systems. We describe the use of two-photon laser microscopy to image the dynamic behavior of individual living lymphocytes deep within intact lymph nodes. In their native environment, T cells achieved peak velocities of more than 25 micrometers per minute, displaying a motility coefficient that is five to six times that of B cells. Antigenic challenge changed T cell trajectories from random walks to "swarms" and stable clusters. Real-time two-photon imaging reveals lymphocyte behaviors that are fundamental to the initiation of the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Mark J -- Wei, Sindy H -- Parker, Ian -- Cahalan, Michael D -- GM-41514/GM/NIGMS NIH HHS/ -- GM-48071/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1869-73. Epub 2002 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016203" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Animals ; Antigen-Presenting Cells/immunology/physiology ; Antigens/*immunology ; B-Lymphocytes/cytology/immunology/physiology ; Cell Division ; Cell Movement ; Cell Size ; Fluoresceins ; Fluorescent Dyes ; Image Processing, Computer-Assisted ; Lasers ; Lymph Nodes/cytology/*immunology ; *Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Microscopy/methods ; Motion Pictures as Topic ; Photons ; Rhodamines ; Succinimides ; T-Lymphocytes/cytology/immunology/*physiology ; Temperature
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bada, Jeffrey L -- Lazcano, Antonio -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):1982-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 02093, USA. jbada@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065824" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/chemistry ; *Biopolymers/chemistry ; Catalysis ; DNA/chemistry ; Earth (Planet) ; *Evolution, Chemical ; *Origin of Life ; Peptides/chemistry ; *Polymers/chemistry ; Protein Biosynthesis ; Proteins/chemistry ; RNA/chemistry ; Temperature ; Thermodynamics
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  • 17
    Publication Date: 2002-11-02
    Description: 1,1,1-Trichloroethane (TCA) is a ubiquitous environmental pollutant because of its widespread use as an industrial solvent, its improper disposal, and its substantial emission to the atmosphere. We report the isolation of an anaerobic bacterium, strain TCA1, that reductively dechlorinates TCA to 1,1-dichloroethane and chloroethane. Strain TCA1 required H2 as an electron donor and TCA as an electron acceptor for growth, indicating that dechlorination is a respiratory process. Phylogenetic analysis indicated that strain TCA1 is related to gram-positive bacteria with low DNA G+C content and that its closest relative is Dehalobacter restrictus, an obligate H2-oxidizing, chloroethene-respiring bacterium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Baolin -- Griffin, Benjamin M -- Ayala-del-Rio, Hector L -- Hashsham, Syed A -- Tiedje, James M -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1023-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Microbial Ecology, Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824-1325, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411705" target="_blank"〉PubMed〈/a〉
    Keywords: Anaerobiosis ; Bacteria, Anaerobic/classification/cytology/isolation & purification/metabolism ; Base Composition ; Biodegradation, Environmental ; Culture Media ; DNA, Ribosomal/genetics ; Electron Transport ; Energy Metabolism ; Environmental Pollutants/*metabolism ; Ethyl Chloride/metabolism ; Formates/metabolism ; Geologic Sediments/*microbiology ; Hydrogen/metabolism ; Oxidation-Reduction ; Peptococcaceae/classification/cytology/growth & development/*isolation & ; purification/*metabolism ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Soil Microbiology ; Temperature ; Trichloroethanes/*metabolism
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  • 18
    Publication Date: 2002-12-10
    Description: We demonstrated in laboratory experiments that temperature control of marine bacteria action on diatoms strongly influences the coupling of biogenic silica and organic carbon preservation. Low temperature intensified the selective regeneration of organic matter by marine bacteria as the silicon:carbon preservation ratio gradually increased from approximately 1 at 33 degrees C to approximately 6 at -1.8 degrees C. Temperature control of bacteria-mediated selective preservation of silicon versus carbon should help to interpret and model the variable coupling of silicon and carbon sinking fluxes and the spatial patterns of opal accumulation in oceanic systems with different temperature regimes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bidle, Kay D -- Manganelli, Maura -- Azam, Farooq -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1980-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0202, USA. bidle@imcs.rutgers.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471255" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Antarctic Regions ; Bacteria/growth & development/isolation & purification/*metabolism ; California ; Carbon/*metabolism ; Diatoms/*metabolism ; Endopeptidases/metabolism ; Food Chain ; Geologic Sediments ; Hydrolysis ; Oceans and Seas ; Pacific Ocean ; Seawater/chemistry/*microbiology ; Silicon/*metabolism ; Temperature
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  • 19
    Publication Date: 2002-06-18
    Description: To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, and daf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, Barbara A -- Avidan, Michael S -- Crowder, C Michael -- R01 NS045905/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2388-91. Epub 2002 Jun 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12065745" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Phosphoinositide-Dependent Protein Kinases ; Alleles ; Animals ; Anoxia/genetics ; Axons/ultrastructure ; Caenorhabditis elegans/genetics/growth & development/*physiology ; Caenorhabditis elegans Proteins/genetics/*physiology ; Cell Death ; Cell Nucleus/ultrastructure ; Cell Survival ; Forkhead Transcription Factors ; Genes, Helminth ; Intestines/cytology/metabolism ; Longevity ; Movement ; Muscles/cytology/metabolism/ultrastructure ; Mutation ; Mutation, Missense ; Neurons/cytology/metabolism/ultrastructure ; Phenotype ; *Phosphatidylinositol 3-Kinases ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/genetics/physiology ; Receptor, Insulin/genetics/*physiology ; *Signal Transduction ; Temperature ; Transcription Factors/genetics/physiology
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  • 20
    Publication Date: 2002-05-25
    Description: The dynamics of conformational isomerization are explored in a methyl-capped dipeptide, N-acetyl-tryptophan methyl amide (NATMA), using infrared-ultraviolet (IR-UV) hole-filling and IR-induced population transfer spectroscopies. IR radiation selectively excites individual NH stretch vibrational fundamentals of single conformations of the molecule in the early portions of a gas-phase expansion, and then this excited population is collisionally recooled into its conformational minima for subsequent conformation-specific detection. Efficient isomerization is induced by the IR excitation that redistributes population between the same conformations that have population in the absence of IR excitation. The quantum yields for transfer of the population into the various conformational minima depend uniquely on which conformation is excited and on which NH stretch vibration is excited within a given conformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dian, Brian C -- Longarte, Asier -- Zwier, Timothy S -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2369-73. Epub 2002 May 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Purdue University, West Lafayette, IN 47907-1393, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029064" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Physical ; Dipeptides/*chemistry ; Hydrogen Bonding ; Infrared Rays ; Isomerism ; *Lasers ; Molecular Conformation ; Physicochemical Phenomena ; *Protein Conformation ; Spectrum Analysis ; Temperature ; Thermodynamics ; Tryptophan/*analogs & derivatives/*chemistry ; Ultraviolet Rays ; Vibration
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2002 Dec 20;298(5602):2297-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493876" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomical Phenomena ; Astronomy ; Biological Evolution ; Cosmic Radiation ; Elementary Particles ; Genome ; Hominidae ; Humans ; Ion Channels/physiology ; Lasers ; Light ; Microwaves ; Motion Pictures as Topic ; Optics and Photonics ; Retinal Ganglion Cells/physiology ; Rod Opsins/physiology ; *Science ; Sequence Analysis, DNA ; Temperature ; Tomography/methods
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  • 22
    Publication Date: 2002-12-14
    Description: In a decade-long soil warming experiment in a mid-latitude hardwood forest, we documented changes in soil carbon and nitrogen cycling in order to investigate the consequences of these changes for the climate system. Here we show that whereas soil warming accelerates soil organic matter decay and carbon dioxide fluxes to the atmosphere, this response is small and short-lived for a mid-latitude forest, because of the limited size of the labile soil carbon pool. We also show that warming increases the availability of mineral nitrogen to plants. Because plant growth in many mid-latitude forests is nitrogen-limited, warming has the potential to indirectly stimulate enough carbon storage in plants to at least compensate for the carbon losses from soils. Our results challenge assumptions made in some climate models that lead to projections of large long-term releases of soil carbon in response to warming of forest ecosystems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Melillo, J M -- Steudler, P A -- Aber, J D -- Newkirk, K -- Lux, H -- Bowles, F P -- Catricala, C -- Magill, A -- Ahrens, T -- Morrisseau, S -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2173-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA. jmelillo@mbl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481133" target="_blank"〉PubMed〈/a〉
    Keywords: Biodegradation, Environmental ; Carbon/*metabolism ; Carbon Dioxide/metabolism ; *Climate ; *Ecosystem ; Fertilizers ; Massachusetts ; Nitrogen/metabolism ; Plants/*metabolism ; *Soil ; Temperature ; *Trees/metabolism
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  • 23
    Publication Date: 2002-02-16
    Description: Deep-sea hydrothermal vents and cold seeps are submarine springs where nutrient-rich fluids emanate from the sea floor. Vent and seep ecosystems occur in a variety of geological settings throughout the global ocean and support food webs based on chemoautotrophic primary production. Most vent and seep invertebrates arrive at suitable habitats as larvae dispersed by deep-ocean currents. The recent evolution of many vent and seep invertebrate species (〈100 million years ago) suggests that Cenozoic tectonic history and oceanic circulation patterns have been important in defining contemporary biogeographic patterns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Dover, C L -- German, C R -- Speer, K G -- Parson, L M -- Vrijenhoek, R C -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1253-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, College of William and Mary, Williamsburg, VA 23187, USA. cindy_vandover@wm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Ecosystem ; Environment ; Food Chain ; Genetics, Population ; Geography ; Geologic Sediments ; *Invertebrates/classification/genetics/physiology ; Oceans and Seas ; Oxidation-Reduction ; Phylogeny ; *Seawater ; Temperature
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  • 24
    Publication Date: 2002-07-13
    Description: Arabidopsis VRN genes mediate vernalization, the process by which a long period of cold induces a mitotically stable state that leads to accelerated flowering during later development. VRN1 encodes a protein that binds DNA in vitro in a non-sequence-specific manner and functions in stable repression of the major target of the vernalization pathway, the floral repressor FLC. Overexpression of VRN1 reveals a vernalization-independent function for VRN1, mediated predominantly through the floral pathway integrator FT, and demonstrates that VRN1 requires vernalization-specific factors to target FLC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, Yaron Y -- Mesnage, Stephane -- Mylne, Joshua S -- Gendall, Anthony R -- Dean, Caroline -- New York, N.Y. -- Science. 2002 Jul 12;297(5579):243-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12114624" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis/anatomy & histology/*genetics/growth & development/*physiology ; Arabidopsis Proteins/chemistry/*genetics/metabolism/*physiology ; Base Sequence ; Cloning, Molecular ; DNA, Plant/genetics/metabolism ; DNA-Binding Proteins/chemistry/*genetics/*physiology ; Down-Regulation ; Gene Expression Regulation, Plant ; Genes, Plant ; MADS Domain Proteins/genetics/metabolism ; Molecular Sequence Data ; Mutation ; Photoperiod ; Plant Proteins/genetics/metabolism ; Plant Structures/anatomy & histology/physiology ; Plants, Genetically Modified ; Protein Binding ; Recombinant Fusion Proteins/metabolism ; *Repressor Proteins ; Temperature
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  • 25
    Publication Date: 2002-06-08
    Description: The use of direct-write dip-pen nanolithography (DPN) to generate covalently anchored, nanoscale patterns of oligonucleotides on both metallic and insulating substrates is described. Modification of DNA with hexanethiol groups allowed patterning on gold, and oligonucleotides bearing 5'-terminal acrylamide groups could be patterned on derivatized silica. Feature sizes ranging from many micrometers to less than 100 nanometers were achieved, and the resulting patterns exhibited the sequence-specific binding properties of the DNA from which they were composed. The patterns can be used to direct the assembly of individual oligonucleotide-modified particles on a surface, and the deposition of multiple DNA sequences in a single array is demonstrated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demers, L M -- Ginger, D S -- Park, S-J -- Li, Z -- Chung, S-W -- Mirkin, C A -- 1 F32 HG02463/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1836-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Center for Nanofabrication and Molecular Self-Assembly, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052950" target="_blank"〉PubMed〈/a〉
    Keywords: Adsorption ; *DNA/chemistry ; *Gold ; Humidity ; *Microscopy, Atomic Force ; *Nanotechnology ; Nucleic Acid Hybridization ; *Oligodeoxyribonucleotides/chemistry ; Oligonucleotide Array Sequence Analysis ; *Oxides ; Silanes ; *Silicon Compounds ; Sulfhydryl Compounds ; Surface Properties ; Temperature
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  • 26
    Publication Date: 2002-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aristegui, Javier -- Duarte, Carlos M -- Agusti, Susana -- Doval, Marylo -- Alvarez-Salgado, Xose A -- Hansell, Dennis A -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1967.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Facultad de Ciencias del Mar, Campus Universitario de Tafira, Universidad de las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain. jaristegui@dbio.ulpgc.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471250" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon/*metabolism ; *Darkness ; Oceans and Seas ; Organic Chemicals/metabolism ; Oxidation-Reduction ; *Oxygen Consumption ; *Seawater ; Temperature
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  • 27
    Publication Date: 2002-12-10
    Description: Simulated global changes, including warming, increased precipitation, and nitrogen deposition, alone and in concert, increased net primary production (NPP) in the third year of ecosystem-scale manipulations in a California annual grassland. Elevated carbon dioxide also increased NPP, but only as a single-factor treatment. Across all multifactor manipulations, elevated carbon dioxide suppressed root allocation, decreasing the positive effects of increased temperature, precipitation, and nitrogen deposition on NPP. The NPP responses to interacting global changes differed greatly from simple combinations of single-factor responses. These findings indicate the importance of a multifactor experimental approach to understanding ecosystem responses to global change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shaw, M Rebecca -- Zavaleta, Erika S -- Chiariello, Nona R -- Cleland, Elsa E -- Mooney, Harold A -- Field, Christopher B -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1987-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Global Ecology, Carnegie Institution of Washington, 260 Panama Street, Stanford, CA 94305, USA. shaw@globalecology.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471257" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Biomass ; California ; *Carbon Dioxide ; Climate ; *Ecosystem ; Environment ; Geraniaceae/*growth & development ; Poaceae/*growth & development ; Soil ; Temperature ; Weather
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yayanos, A Aristides -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):295.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0202, USA. ayayanos@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130751" target="_blank"〉PubMed〈/a〉
    Keywords: Atmospheric Pressure ; Escherichia coli/growth & development/*physiology ; Formates/metabolism ; Ice ; Oxidation-Reduction ; *Pressure ; Shewanella putrefaciens/growth & development/*physiology ; Temperature
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-14
    Description: We report the observation of a phase of phospholipid that contains a structure similar to the commonly postulated interbilayer state that is crucial to membrane fusion. The widely accepted model for membrane fusion suggests that there is an intermediate state in which the two contacting monolayers become continuous via an hourglass-shaped structure called a stalk. Many efforts have been made to estimate the free energy for such a state in order to understand the functionality of membrane fusion proteins and to define key parameters in energy estimates. The observation of the stalk structure supports the stalk hypothesis for membrane fusion and enables the measurement of these parameters experimentally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang, Lin -- Huang, Huey W -- GM55203/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1877-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228719" target="_blank"〉PubMed〈/a〉
    Keywords: Humidity ; *Lipid Bilayers ; *Membrane Fusion ; Membrane Lipids/*chemistry/physiology ; Phosphatidylcholines/*chemistry/physiology ; Temperature ; Thermodynamics ; Water ; X-Ray Diffraction
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  • 30
    Publication Date: 2002-04-16
    Description: A practical, inexpensive, green chemical process for degrading environmental pollutants is greatly needed, especially for persistent chlorinated pollutants. Here we describe the activation of hydrogen peroxide by tetraamidomacrocylic ligand (TAML) iron catalysts, to destroy the priority pollutants pentachlorophenol (PCP) and 2,4,6-trichlorophenol (TCP). In water, in minutes, under ambient conditions of temperature and pressure, PCP and TCP are completely destroyed at catalyst:substrate ratios of 1:715 and 1:2000, respectively. The fate of about 90% of the carbon and about 99% of the chlorine has been determined in each case. Neither dioxins nor any other toxic compounds are detectable products, and the catalysts themselves show low toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, Sayam Sen -- Stadler, Matthew -- Noser, Christopher A -- Ghosh, Anindya -- Steinhoff, Bradley -- Lenoir, Dieter -- Horwitz, Colin P -- Schramm, Karl-Werner -- Collins, Terrence J -- GM44867-05/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):326-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951040" target="_blank"〉PubMed〈/a〉
    Keywords: Catalysis ; Chlorine Compounds/chemistry ; Chlorophenols/*chemistry ; Dioxins/chemistry ; Environmental Pollutants ; Ferric Compounds/*chemistry/toxicity ; Gas Chromatography-Mass Spectrometry ; Heterocyclic Compounds with 4 or More Rings/*chemistry/toxicity ; Hydrogen Peroxide/*chemistry ; Hydrogen-Ion Concentration ; Kinetics ; Magnetic Resonance Spectroscopy ; Oxidation-Reduction ; Pentachlorophenol/*chemistry ; Pressure ; Spectrometry, Mass, Electrospray Ionization ; Temperature
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  • 31
    Publication Date: 2002-12-21
    Description: The North Atlantic is believed to represent the largest ocean sink for atmospheric carbon dioxide in the Northern Hemisphere, yet little is known about its temporal variability. We report an 18-year time series of upper-ocean inorganic carbon observations from the northwestern subtropical North Atlantic near Bermuda that indicates substantial variability in this sink. We deduce that the carbon variability at this site is largely driven by variations in winter mixed-layer depths and by sea surface temperature anomalies. Because these variations tend to occur in a basinwide coordinated pattern associated with the North Atlantic Oscillation, it is plausible that the entire North Atlantic Ocean may vary in concert, resulting in a variability of the strength of the North Atlantic carbon sink of about +/-0.3 petagrams of carbon per year (1 petagram = 10(15) grams) or nearly +/-50%. This extrapolation is supported by basin-wide estimates from atmospheric carbon dioxide inversions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gruber, Nicolas -- Keeling, Charles D -- Bates, Nicholas R -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2374-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Geophysics and Planetary Physics and Department of Atmospheric Sciences, University of California, Los Angeles, CA 90095, USA. ngruber@igpp.ucla.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493911" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Atmosphere ; Bermuda ; Carbon/*analysis ; Carbon Dioxide/*analysis/metabolism ; Carbon Isotopes/analysis ; Climate ; Models, Theoretical ; Photosynthesis ; Seasons ; Seawater/*chemistry ; Temperature
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  • 32
    Publication Date: 2002-06-22
    Description: Infectious diseases can cause rapid population declines or species extinctions. Many pathogens of terrestrial and marine taxa are sensitive to temperature, rainfall, and humidity, creating synergisms that could affect biodiversity. Climate warming can increase pathogen development and survival rates, disease transmission, and host susceptibility. Although most host-parasite systems are predicted to experience more frequent or severe disease impacts with warming, a subset of pathogens might decline with warming, releasing hosts from disease. Recently, changes in El Nino-Southern Oscillation events have had a detectable influence on marine and terrestrial pathogens, including coral diseases, oyster pathogens, crop pathogens, Rift Valley fever, and human cholera. To improve our ability to predict epidemics in wild populations, it will be necessary to separate the independent and interactive effects of multiple climate drivers on disease impact.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvell, C Drew -- Mitchell, Charles E -- Ward, Jessica R -- Altizer, Sonia -- Dobson, Andrew P -- Ostfeld, Richard S -- Samuel, Michael D -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2158-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA. cdh5@cornell.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic ; *Animals, Wild ; Bacterial Physiological Phenomena ; *Climate ; Communicable Diseases, Emerging/epidemiology/etiology/transmission/veterinary ; Disease Outbreaks ; Disease Vectors ; *Ecosystem ; Fungi/physiology ; Humans ; *Infection/epidemiology/etiology/transmission/veterinary ; Parasites/physiology ; *Plant Diseases/etiology ; Risk Factors ; Seasons ; Seawater ; Temperature ; Virus Physiological Phenomena
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  • 33
    Publication Date: 2002-08-31
    Description: The latitudinal gradient of increasing biodiversity from poles to equator is one of the most prominent but least understood features of life on Earth. Here we show that species diversity can be predicted from the biochemical kinetics of metabolism. We first demonstrate that the average energy flux of populations is temperature invariant. We then derive a model that quantitatively predicts how species diversity increases with environmental temperature. Predictions are supported by data for terrestrial, freshwater, and marine taxa along latitudinal and elevational gradients. These results establish a thermodynamic basis for the regulation of species diversity and the organization of ecological communities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Andrew P -- Brown, James H -- Gillooly, James F -- New York, N.Y. -- Science. 2002 Aug 30;297(5586):1545-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. drewa@unm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12202828" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Constitution ; *Ecosystem ; Kinetics ; *Models, Biological ; Plants ; Temperature ; Thermodynamics
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dziak, Robert P -- Johnson, H Paul -- New York, N.Y. -- Science. 2002 May 24;296(5572):1406-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029115" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Physiological Phenomena ; *Disasters ; *Ecosystem ; Geologic Sediments/microbiology ; Hydrostatic Pressure ; Pacific Ocean ; Photosynthesis ; Pressure ; *Seawater ; Temperature ; Time Factors ; Water Movements
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  • 35
    Publication Date: 2002-02-23
    Description: We observed physiological and metabolic activity of Shewanella oneidensis strain MR1 and Escherichia coli strain MG1655 at pressures of 68 to 1680 megapascals (MPa) in diamond anvil cells. We measured biological formate oxidation at high pressures (68 to 1060 MPa). At pressures of 1200 to 1600 MPa, living bacteria resided in fluid inclusions in ice-VI crystals and continued to be viable upon subsequent release to ambient pressures (0.1 MPa). Evidence of microbial viability and activity at these extreme pressures expands by an order of magnitude the range of conditions representing the habitable zone in the solar system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, Anurag -- Scott, James H -- Cody, George D -- Fogel, Marilyn L -- Hazen, Robert M -- Hemley, Russell J -- Huntress, Wesley T -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1514-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geophysical Laboratory, Carnegie Institution of Washington, 5251 Broad Branch Road, N.W., Washington, DC 20015, USA. sharma@gl.ciw.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859192" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Diamond ; Escherichia coli/cytology/metabolism/*physiology ; Formates/*metabolism ; Ice ; Methylene Blue/metabolism ; Movement ; Oxidation-Reduction ; *Pressure ; Shewanella putrefaciens/cytology/metabolism/*physiology ; Spectrum Analysis, Raman ; Temperature
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  • 36
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-16
    Description: Multiple environmental and endogenous inputs regulate when plants flower. The molecular genetic dissection of flowering time control in Arabidopsis has identified an integrated network of pathways that quantitatively control the timing of this developmental switch. This framework provides the basis to understand the evolution of different reproductive strategies and how floral pathways interact through seasonal progression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, Gordon G -- Dean, Caroline -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):285-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, John Innes Centre, Norwich, NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11951029" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics/growth & development/*physiology ; Arabidopsis Proteins/genetics/*metabolism ; Circadian Rhythm ; DNA-Binding Proteins/genetics/physiology ; *Gene Expression Regulation, Plant ; Genes, Plant ; Gibberellins/metabolism ; Meristem/physiology ; Mutation ; Photoperiod ; Plant Structures/physiology ; Seasons ; Temperature ; Time Factors ; Transcription Factors/genetics/physiology
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wachtershauser, Gunter -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):747-9; author reply 747-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12400545" target="_blank"〉PubMed〈/a〉
    Keywords: *Biopolymers/chemistry ; *Evolution, Chemical ; Hydrolysis ; *Origin of Life ; *Polymers/chemistry ; Temperature
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  • 38
    Publication Date: 2002-01-19
    Description: The separate components of nucleocytoplasmic transport have been well characterized, including the key regulatory role of Ran, a guanine nucleotide triphosphatase. However, the overall system behavior in intact cells is difficult to analyze because the dynamics of these components are interdependent. We used a combined experimental and computational approach to study Ran transport in vivo. The resulting model provides the first quantitative picture of Ran flux between the nuclear and cytoplasmic compartments in eukaryotic cells. The model predicts that the Ran exchange factor RCC1, and not the flux capacity of the nuclear pore complex (NPC), is the crucial regulator of steady-state flux across the NPC. Moreover, it provides the first estimate of the total in vivo flux (520 molecules per NPC per second and predicts that the transport system is robust.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, Alicia E -- Slepchenko, Boris M -- Schaff, James C -- Loew, Leslie M -- Macara, Ian G -- GM-50526/GM/NIGMS NIH HHS/ -- NCRR-RR13186/RR/NCRR NIH HHS/ -- NIH-GM-20438/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):488-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell Signaling, Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799242" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; *Cell Cycle Proteins ; Cell Line ; Cell Nucleus/metabolism ; *Computer Simulation ; Cricetinae ; Cytoplasm/metabolism ; Diffusion ; Fluorescence ; Guanine Nucleotide Exchange Factors/metabolism ; Guanosine Triphosphate/metabolism ; Kinetics ; Mathematics ; *Models, Biological ; Mutation ; Nuclear Pore/*metabolism ; *Nuclear Proteins ; Nucleocytoplasmic Transport Proteins/metabolism ; Recombinant Proteins/metabolism ; Temperature ; ran GTP-Binding Protein/genetics/*metabolism
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  • 39
    Publication Date: 2002-02-23
    Description: A 420-year history of strontium/calcium, uranium/calcium, and oxygen isotope ratios in eight coral cores from the Great Barrier Reef, Australia, indicates that sea surface temperature and salinity were higher in the 18th century than in the 20th century. An abrupt freshening after 1870 occurred simultaneously throughout the southwestern Pacific, coinciding with cooling tropical temperatures. Higher salinities between 1565 and 1870 are best explained by a combination of advection and wind-induced evaporation resulting from a strong latitudinal temperature gradient and intensified circulation. The global Little Ice Age glacial expansion may have been driven, in part, by greater poleward transport of water vapor from the tropical Pacific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hendy, Erica J -- Gagan, Michael K -- Alibert, Chantal A -- McCulloch, Malcolm T -- Lough, Janice M -- Isdale, Peter J -- New York, N.Y. -- Science. 2002 Feb 22;295(5559):1511-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research School of Earth Sciences, Australian National University, Canberra, ACT 0200, Australia. erica.hendy@anu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11859191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Australia ; Calcium/analysis ; *Cnidaria ; Oxygen Isotopes/analysis ; Pacific Ocean ; Seawater/*chemistry ; Sodium Chloride/*analysis ; Strontium/analysis ; Temperature ; Time ; Tropical Climate ; Uranium/analysis
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-05
    Description: Reduction in severe disease and death from falciparum malaria in Africa requires new, more effective and inexpensive public health measures. The completed genomes of Plasmodium falciparum and its vector Anopheles gambiae represent a big step toward the discovery of these needed tools.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Louis H -- Greenwood, Brian -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):121-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364787" target="_blank"〉PubMed〈/a〉
    Keywords: Africa South of the Sahara/epidemiology ; Animals ; *Anopheles/genetics/parasitology/physiology ; Antimalarials/therapeutic use ; Child ; Clinical Trials as Topic ; Drug Resistance ; Drug Therapy, Combination ; Endemic Diseases ; Feeding Behavior ; Genome ; Genome, Protozoan ; Humans ; Insect Bites and Stings ; *Insect Vectors/genetics/parasitology/physiology ; Malaria/drug therapy/epidemiology/*prevention & control/transmission ; Malaria Vaccines ; Malaria, Falciparum/drug therapy/epidemiology/*prevention & control/transmission ; Mosquito Control ; Plasmodium falciparum/drug effects/genetics/growth & development ; Sequence Analysis, DNA ; Temperature
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  • 41
    Publication Date: 2002-07-06
    Description: Blue light regulates many physiological processes in fungi, but their photoreceptors are not known. In Neurospora crassa, all light responses depend on the Per-Arnt-Sim (PAS) domain-containing transcription factor white collar-1 (wc-1). By removing the WC-1 light, oxygen, or voltage domain, a specialized PAS domain that binds flavin mononucleotide in plant phototropins, we show that light responses are abolished, including light entrainment of the circadian clock. However, the WC-1-mediated dark activation of frq remains normal in this mutant, and the circadian clock can be entrained by temperature. Furthermore, we demonstrate that the purified Neurospora WC-1-WC-2 protein complex is associated with stoichiometric amounts of the chromophore flavin-adenine dinucleotide. Together, these observations suggest that WC-1 is the blue-light photoreceptor for the circadian clock and other light responses in Neurospora.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Qiyang -- Cheng, Ping -- Yang, Yuhong -- Wang, Lixing -- Gardner, Kevin H -- Liu, Yi -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):840-3. Epub 2002 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098705" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Circadian Rhythm/radiation effects ; Color ; DNA, Fungal/genetics/metabolism ; DNA-Binding Proteins/chemistry/deficiency/genetics/*metabolism ; Darkness ; Dimerization ; Flavin Mononucleotide/metabolism ; Flavin-Adenine Dinucleotide/metabolism ; Fungal Proteins/chemistry/genetics/metabolism ; Gene Deletion ; Gene Expression Regulation, Fungal/radiation effects ; *Light ; Molecular Sequence Data ; Neurospora crassa/genetics/*metabolism/radiation effects ; Oxygen/metabolism ; Photoreceptors, Microbial/chemistry/genetics/*metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Structure, Tertiary ; Response Elements/genetics ; Temperature ; Transcription Factors/chemistry/deficiency/genetics/*metabolism
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  • 42
    Publication Date: 2002-01-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quayle, Wendy C -- Peck, Lloyd S -- Peat, Helen -- Ellis-Evans, J C -- Harrigan, P Richard -- New York, N.Y. -- Science. 2002 Jan 25;295(5555):645.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge CB3 0ET, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11809962" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Chlorophyll/analysis ; *Climate ; *Ecosystem ; *Fresh Water ; Light ; Phytoplankton/*physiology ; Seasons ; Temperature
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  • 43
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quay, Paul -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2344.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Oceanography, University of Washington, Seattle, WA 98195, USA. pdquay@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493904" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Atmosphere ; Bermuda ; Carbon/analysis ; Carbon Dioxide/*analysis/metabolism ; *Climate ; Models, Theoretical ; Photosynthesis ; Seasons ; Seawater/*chemistry ; Temperature
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  • 44
    Publication Date: 2002-12-14
    Description: Theory predicts the existence of barrierless protein folding. Without barriers, folding should be noncooperative and the degree of native structure should be coupled to overall protein stability. We investigated the thermal unfolding of the peripheral subunit binding domain from Escherichia coli's 2-oxoglutarate dehydrogenase multienzyme complex (termed BBL) with a combination of spectroscopic techniques and calorimetry. Each technique probed a different feature of protein structure. BBL has a defined three-dimensional structure at low temperatures. However, each technique showed a distinct unfolding transition. Global analysis with a statistical mechanical model identified BBL as a downhill-folding protein. Because of BBL's biological function, we propose that downhill folders may be molecular rheostats, in which effects could be modulated by altering the distribution of an ensemble of structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia-Mira, Maria M -- Sadqi, Mourad -- Fischer, Niels -- Sanchez-Ruiz, Jose M -- Munoz, Victor -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2191-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry and Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481137" target="_blank"〉PubMed〈/a〉
    Keywords: Acyltransferases/*chemistry ; Calorimetry, Differential Scanning ; Circular Dichroism ; Escherichia coli/enzymology ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Hydrogen-Ion Concentration ; Ketoglutarate Dehydrogenase Complex/*chemistry ; Models, Chemical ; Models, Molecular ; Multienzyme Complexes/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Protein Denaturation ; *Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; Temperature ; Thermodynamics
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matlin, Nathaniel A -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):747-9; author reply 747-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12400544" target="_blank"〉PubMed〈/a〉
    Keywords: *Biopolymers/chemistry ; *Evolution, Chemical ; *Origin of Life ; Polymers/chemistry ; Temperature
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  • 46
    Publication Date: 2002-12-10
    Description: The martian valley networks formed near the end of the period of heavy bombardment of the inner solar system, about 3.5 billion years ago. The largest impacts produced global blankets of very hot ejecta, ranging in thickness from meters to hundreds of meters. Our simulations indicated that the ejecta warmed the surface, keeping it above the freezing point of water for periods ranging from decades to millennia, depending on impactor size, and caused shallow subsurface or polar ice to evaporate or melt. Large impacts also injected steam into the atmosphere from the craters or from water innate to the impactors. From all sources, a typical 100-, 200-, or 250-kilometers asteroid injected about 2, 9, or 16 meters, respectively, of precipitable water into the atmosphere, which eventually rained out at a rate of about 2 meters per year. The rains from a large impact formed rivers and contributed to recharging aquifers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Segura, Teresa L -- Toon, Owen B -- Colaprete, Anthony -- Zahnle, Kevin -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1977-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Atmospheric and Oceanic Sciences, Laboratory for Atmospheric and Space Physics, University of Colorado, Campus Box 392, Boulder, CO 80309-0392, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471254" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Carbon Dioxide ; Computer Simulation ; Exobiology ; Extraterrestrial Environment ; Ice ; Life ; *Mars ; *Minor Planets ; Temperature ; *Water
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-11-09
    Description: Opinion has long been divided as to whether the Mg/Ca ratio of seawater remained constant during the Phanerozoic or underwent substantial secular change. Existing empirical evidence for the Mg/Ca of ancient seawater provides a poorly resolved and often controversial signal. Echinoderm fossils that have retained their bulk original chemistry, despite micrometer-scale changes, preserve a record of seawater Mg/Ca and confirm that major changes in Mg/Ca occurred during the Phanerozoic. Echinoderms from the Cambrian and from the Carboniferous to the Triassic indicate a seawater Mg/Ca of approximately 3.3, whereas echinoderms from the Jurassic to the Cretaceous indicate a Mg/Ca of approximately 1.4. The present seawater Mg/Ca is approximately 5.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dickson, J A D -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1222-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EQ, UK. jadd1@esc.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424375" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*analysis ; Calcium Carbonate/analysis ; Echinodermata/*chemistry ; *Fossils ; Geological Phenomena ; Geology ; Magnesium/*analysis ; Sea Urchins/*chemistry ; Seawater/*chemistry ; Temperature ; Time
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  • 48
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Meer, Gerrit -- New York, N.Y. -- Science. 2002 May 3;296(5569):855-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Membrane Enzymology, CBLE, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands. g.vanmeer@chem.uu.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988557" target="_blank"〉PubMed〈/a〉
    Keywords: Acylation ; Caveolae/metabolism ; Cholesterol/analysis ; Energy Transfer ; Fluorescence ; Glycosylphosphatidylinositols/analysis ; Green Fluorescent Proteins ; Lipid Metabolism ; Luminescent Proteins/*metabolism ; Membrane Microdomains/chemistry/*metabolism/physiology ; Models, Biological ; Protein Prenylation ; Proteins/*metabolism ; Signal Transduction ; Spectrometry, Fluorescence ; Sphingolipids/analysis ; Temperature
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  • 49
    Publication Date: 2002-12-10
    Description: Circadian clocks are influenced by social interactions in a variety of species, but little is known about the sensory mechanisms underlying these effects. We investigated whether social cues could reset circadian rhythms in Drosophila melanogaster by addressing two questions: Is there a social influence on circadian timing? If so, then how is that influence communicated? The experiments show that in a social context Drosophila transmit and receive cues that influence circadian time and that these cues are likely olfactory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, Joel D -- Funes, Pablo -- Dowse, Harold B -- Hall, Jeffrey C -- GM-33205/GM/NIGMS NIH HHS/ -- NS-44232/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):2010-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Brandeis University, Waltham, MA 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; *Circadian Rhythm ; *Cues ; Darkness ; Drosophila Proteins/genetics/physiology ; Drosophila melanogaster/genetics/*physiology ; Light ; Male ; Motor Activity ; Mutation ; Nuclear Proteins/genetics/physiology ; Period Circadian Proteins ; Smell/physiology ; Social Behavior ; Sodium Channels/genetics/physiology ; Temperature
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  • 50
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greene, Katie -- New York, N.Y. -- Science. 2002 Mar 8;295(5561):1823.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884735" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; *Ecosystem ; Fishes/*physiology ; Pacific Ocean ; *Seawater ; Temperature ; Zooplankton/*physiology
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  • 51
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawrence, Mark G -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1993.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12243191" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Carbon Dioxide/metabolism ; Climate ; *Ecosystem ; Fertilizers ; Hydrocarbons, Halogenated/metabolism ; *Iron ; Oceans and Seas ; Phytoplankton/*physiology ; *Seawater ; Sulfides/metabolism ; Temperature
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  • 52
    Publication Date: 2002-11-09
    Description: Infrared spectroscopy is used extensively in the study of isolated biomolecules, but it becomes less useful as it is applied to systems of increasing complexity. Even if the individual vibrational bands can be resolved spectroscopically, their assignment becomes problematic when they are more closely spaced than can be determined using ab initio methods. We describe a method that helps to alleviate this difficulty by measuring the direction of the vibrational transition moment for each vibrational band. The molecules of interest (adenine and cytosine) are cooled to 0.37 kelvin in liquid helium nanodroplets and oriented in a large dc electric field. A polarized infrared laser is then used to determine the directions of the infrared transition moments relative to the permanent dipole moment. Comparisons with ab initio calculations provide detailed structural information, including experimental evidence for nonplanarity of adenine and three tautomers of cytosine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, F -- Miller, R E -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1227-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424376" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine/*chemistry ; Chemistry, Physical ; Cytosine/*chemistry ; Helium ; Physicochemical Phenomena ; *Spectrophotometry, Infrared ; Temperature ; Vibration
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  • 53
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2002 May 10;296(5570):1056-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004113" target="_blank"〉PubMed〈/a〉
    Keywords: Archaea/*physiology ; *Bacterial Physiological Phenomena ; Biomass ; Colony Count, Microbial ; Energy Metabolism ; *Environmental Microbiology ; Exobiology ; Geologic Sediments/*microbiology ; Hydrogen/metabolism ; Mining ; Oceans and Seas ; Seawater ; Temperature ; *Water Microbiology
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  • 54
    Publication Date: 2002-02-16
    Description: Synchrotron x-radiography and a fast x-ray detector were used to record the time evolution of the transient fuel sprays from a high-pressure injector. A succession of 5.1-microsecond radiographs captured the propagation of the spray-induced shock waves in a gaseous medium and revealed the complex nature of the spray hydrodynamics. The monochromatic x-radiographs also allow quantitative analysis of the shock waves that has been difficult if not impossible with optical imaging. Under injection conditions similar to those found in operating engines, the fuel jets can exceed supersonic speeds and result in gaseous shock waves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacPhee, Andrew G -- Tate, Mark W -- Powell, Christopher F -- Yue, Yong -- Renzi, Matthew J -- Ercan, Alper -- Narayanan, Suresh -- Fontes, Ernest -- Walther, Jochen -- Schaller, Johannes -- Gruner, Sol M -- Wang, Jin -- DMR-9713424/PHS HHS/ -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1261-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Advanced Photon Source and, Energy System Division, Argonne National Laboratory, Argonne, IL 60439, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847333" target="_blank"〉PubMed〈/a〉
    Keywords: Cerium ; *Gasoline ; *Pressure ; Rheology ; Sulfur Hexafluoride ; *Synchrotrons ; Temperature ; *X-Rays
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  • 55
    Publication Date: 2002-04-06
    Description: The nucleus of the Jupiter-family comet 19P/Borrelly was closely observed by the Miniature Integrated Camera and Spectrometer aboard the Deep Space 1 spacecraft on 22 September 2001. The 8-kilometer-long body is highly variegated on a scale of 200 meters, exhibiting large albedo variations (0.01 to 0.03) and complex geologic relationships. Short-wavelength infrared spectra (1.3 to 2.6 micrometers) show a slope toward the red and a hot, dry surface (〈/=345 kelvin, with no trace of water ice or hydrated minerals), consistent with approximately 10% or less of the surface actively sublimating. Borrelly's coma exhibits two types of dust features: fans and highly collimated jets. At encounter, the near-nucleus coma was dominated by a prominent dust jet that resolved into at least three smaller jets emanating from a broad basin in the middle of the nucleus. Because the major dust jet remained fixed in orientation, it is evidently aligned near the rotation axis of the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soderblom, L A -- Becker, T L -- Bennett, G -- Boice, D C -- Britt, D T -- Brown, R H -- Buratti, B J -- Isbell, C -- Giese, B -- Hare, T -- Hicks, M D -- Howington-Kraus, E -- Kirk, R L -- Lee, M -- Nelson, R M -- Oberst, J -- Owen, T C -- Rayman, M D -- Sandel, B R -- Stern, S A -- Thomas, N -- Yelle, R V -- New York, N.Y. -- Science. 2002 May 10;296(5570):1087-91. Epub 2002 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United States Geological Survey, 2255 North Gemini Drive, Flagstaff, AZ 86001, USA. lsoderblom@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934989" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon/analysis ; Cosmic Dust ; Hydrocarbons/analysis ; *Meteoroids ; Spectrum Analysis ; Temperature
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  • 56
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovett, Richard A -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1787.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052933" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; *Carbon Dioxide/metabolism ; Computer Simulation ; *Greenhouse Effect ; Photosynthesis ; *Plant Development ; Plants/metabolism ; *Rain ; Temperature ; Trees/growth & development/metabolism ; United States
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  • 57
    Publication Date: 2002-05-11
    Description: Light-powered molecular machines are conjectured to be essential constituents of future nanoscale devices. As a model for such systems, we have synthesized a polymer of bistable photosensitive azobenzenes. Individual polymers were investigated by single-molecule force spectroscopy in combination with optical excitation in total internal reflection. We were able to optically lengthen and contract individual polymers by switching the azo groups between their trans and cis configurations. The polymer was found to contract against an external force acting along the polymer backbone, thus delivering mechanical work. As a proof of principle, the polymer was operated in a periodic mode, demonstrating for the first time optomechanical energy conversion in a single-molecule device.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hugel, Thorsten -- Holland, Nolan B -- Cattani, Anna -- Moroder, Luis -- Seitz, Markus -- Gaub, Hermann E -- New York, N.Y. -- Science. 2002 May 10;296(5570):1103-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lehrstuhl fur Angewandte Physik & Center for Nanoscience, Ludwig-Maximilians Universitat, Amalienstrasse 54, 80799 Munchen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004125" target="_blank"〉PubMed〈/a〉
    Keywords: Azo Compounds/*chemistry ; Chemistry, Physical ; Dimethyl Sulfoxide ; *Light ; Mechanics ; Microscopy, Atomic Force ; Molecular Conformation ; Nanotechnology ; Optics and Photonics ; Peptides/*chemistry ; Photochemistry ; Physicochemical Phenomena ; Polymers ; Protein Conformation ; Software ; Spectrum Analysis ; Temperature
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  • 58
    Publication Date: 2002-06-01
    Description: After 55 days of mapping by the High Energy Neutron Detector onboard Mars Odyssey, we found deficits of high-energy neutrons in the southern highlands and northern lowlands of Mars. These deficits indicate that hydrogen is concentrated in the subsurface. Modeling suggests that water ice-rich layers that are tens of centimeters in thickness provide one possible fit to the data.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mitrofanov, I -- Anfimov, D -- Kozyrev, A -- Litvak, M -- Sanin, A -- Tret'yakov, V -- Krylov, A -- Shvetsov, V -- Boynton, W -- Shinohara, C -- Hamara, D -- Saunders, R S -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):78-81. Epub 2002 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Space Research, Moscow 117997, Russia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040089" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Cosmic Radiation ; Extraterrestrial Environment ; *Hydrogen ; *Ice ; *Mars ; Models, Theoretical ; *Neutrons ; Spacecraft ; Spectrometry, Gamma ; Spectrum Analysis ; Temperature
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  • 59
    Publication Date: 2002-09-21
    Description: The SecA adenosine triphosphatase (ATPase) mediates extrusion of the amino termini of secreted proteins from the eubacterial cytosol based on cycles of reversible binding to the SecYEG translocon. We have determined the crystal structure of SecA with and without magnesium-adenosine diphosphate bound to the high-affinity ATPase site at 3.0 and 2.7 angstrom resolution, respectively. Candidate sites for preprotein binding are located on a surface containing the SecA epitopes exposed to the periplasm upon binding to SecYEG and are thus positioned to deliver preprotein to SecYEG. Comparisons with structurally related ATPases, including superfamily I and II ATP-dependent helicases, suggest that the interaction geometry of the tandem motor domains in SecA is modulated by nucleotide binding, which is shown by fluorescence anisotropy experiments to reverse an endothermic domain-dissociation reaction hypothesized to gate binding to SecYEG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hunt, John F -- Weinkauf, Sevil -- Henry, Lisa -- Fak, John J -- McNicholas, Paul -- Oliver, Donald B -- Deisenhofer, Johann -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):2018-26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, 702A Fairchild Center, MC2434, Columbia University, New York, NY 10027, USA. hunt@sid.bio.columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242434" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/chemistry/*metabolism ; Adenosine Triphosphatases/*chemistry/*metabolism ; Adenosine Triphosphate/chemistry/*metabolism ; Amino Acid Motifs ; Amino Acid Sequence ; Bacillus subtilis/*enzymology ; Bacterial Proteins/*chemistry/metabolism ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; DNA Helicases/chemistry ; DNA, Bacterial/chemistry/metabolism ; DNA, Single-Stranded/chemistry/metabolism ; Dimerization ; Escherichia coli ; Escherichia coli Proteins/*chemistry/*metabolism ; Eukaryotic Initiation Factor-4A ; Fluorescence Polarization ; Fourier Analysis ; Hydrogen Bonding ; Ligands ; Membrane Transport Proteins/*chemistry/*metabolism ; Models, Molecular ; Molecular Sequence Data ; Peptide Initiation Factors/chemistry ; Peptides/chemistry ; Protein Binding ; Protein Conformation ; Protein Folding ; Protein Precursors/metabolism ; Protein Structure, Secondary ; *Protein Structure, Tertiary ; Temperature
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  • 60
    Publication Date: 2002-01-19
    Description: The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arantes-Oliveira, Nuno -- Apfeld, Javier -- Dillin, Andrew -- Kenyon, Cynthia -- New York, N.Y. -- Science. 2002 Jan 18;295(5554):502-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143-0448, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11799246" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Caenorhabditis elegans/*cytology/genetics/growth & development/*physiology ; Caenorhabditis elegans Proteins/genetics/physiology ; Cell Differentiation ; Cell Division ; Female ; Forkhead Transcription Factors ; Genes, Helminth ; Germ Cells/*cytology/physiology ; *Longevity ; Male ; Meiosis ; Mitosis ; Mutation ; Oxidative Stress ; Stem Cells/*physiology ; Temperature ; Transcription Factors/genetics/physiology
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  • 61
    Publication Date: 2002-06-29
    Description: Phototaxis and photophobic responses of green algae are mediated by rhodopsins with microbial-type chromophores. We report a complementary DNA sequence in the green alga Chlamydomonas reinhardtii that encodes a microbial opsin-related protein, which we term Channelopsin-1. The hydrophobic core region of the protein shows homology to the light-activated proton pump bacteriorhodopsin. Expression of Channelopsin-1, or only the hydrophobic core, in Xenopus laevis oocytes in the presence of all-trans retinal produces a light-gated conductance that shows characteristics of a channel selectively permeable for protons. We suggest that Channelrhodopsins are involved in phototaxis of green algae.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagel, Georg -- Ollig, Doris -- Fuhrmann, Markus -- Kateriya, Suneel -- Musti, Anna Maria -- Bamberg, Ernst -- Hegemann, Peter -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2395-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institut fur Biophysik, Kennedyallee 70, 60596 Frankfurt am Main, Germany. nagel@mpibp-frankfurt.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12089443" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Bacteriorhodopsins/chemistry/metabolism ; Butyric Acid/pharmacology ; Chlamydomonas reinhardtii/chemistry/genetics/*metabolism ; Electric Conductivity ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Ion Channels/*chemistry/genetics/*metabolism ; Ion Transport ; *Light ; Membrane Potentials ; Molecular Sequence Data ; Oocytes ; Patch-Clamp Techniques ; *Protons ; RNA, Complementary ; Recombinant Proteins/metabolism ; Retinaldehyde/pharmacology ; Sequence Alignment ; Temperature ; Xenopus laevis
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  • 62
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, Thomas H -- Vickers-Rich, Patricia -- Gangloff, Roland A -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):979-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Museum Victoria, Post Office Box 666E, Melbourne, Victoria 3001, Australia. trich@museum.vic.gov.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834803" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Alaska ; Animals ; Arctic Regions ; Australia ; *Cold Climate ; *Dinosaurs ; Ecosystem ; Environment ; *Fossils ; Temperature
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  • 63
    Publication Date: 2002-07-06
    Description: We used Arabidopsis thaliana mutants to examine how a photosynthetic regulatory process, the qE-type or DeltapH-dependent nonphotochemical quenching, hereafter named feedback de-excitation, influences plant fitness in different light environments. We show that the feedback de-excitation is important for plant fitness in the field and in fluctuating light in a controlled environment but that it does not affect plant performance under constant light conditions. Our findings demonstrate that the feedback de-excitation confers a strong fitness advantage under field conditions and suggest that this advantage is due to the increase in plant tolerance to variation in light intensity rather than tolerance to high-intensity light itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kulheim, Carsten -- Agren, Jon -- Jansson, Stefan -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):91-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Umea Plant Science Center, Department of Plant Physiology, Umea University, SE-901 87 Umea, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098696" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Arabidopsis/genetics/growth & development/*physiology ; Arabidopsis Proteins/genetics/metabolism ; Electron Transport ; *Feedback, Physiological ; Genotype ; Hydrogen-Ion Concentration ; *Light ; Light-Harvesting Protein Complexes ; Mutation ; Oxidoreductases/genetics/*metabolism ; Photosynthesis ; Photosynthetic Reaction Center Complex Proteins/genetics/*metabolism ; *Photosystem II Protein Complex ; *Plant Proteins ; Temperature
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  • 64
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: The occurrence of carbon isotope minima at the beginning of glacial terminations is a common feature of planktic foraminifera carbon isotopic records from the Indo-Pacific, sub-Antarctic, and South Atlantic. We use the delta13C record of a thermocline-dwelling foraminifera, Neogloboquadrina dutertrei, and surface temperature estimates from the eastern equatorial Pacific to demonstrate that the onset of delta13C minimum events and the initiation of Southern Ocean warming occurred simultaneously. Timing agreement between the marine record and the delta13C minimum in an Antarctic atmospheric record suggests that the deglacial events were a response to the breakdown of surface water stratification, renewed Circumpolar Deep Water upwelling, and advection of low delta13C waters to the convergence zone at the sub-Antarctic front. On the basis of age agreement between the absolute delta13C minimum in surface records and the shift from low to high delta13C in the deep South Atlantic, we suggest that the delta13C rise that marks the end of the carbon isotope minima was due to the resumption of North Atlantic Deep Water influence in the Southern Ocean.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spero, Howard J -- Lea, David W -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):522-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology, University of California, Davis, CA 95616, USA. spero@geology.ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964477" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Carbon Dioxide ; Carbon Isotopes/*analysis ; *Climate ; Geologic Sediments ; Oxygen Isotopes/analysis ; Pacific Ocean ; *Plankton ; *Seawater ; Temperature ; Time
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  • 65
    Publication Date: 2002-12-10
    Description: The Mars Odyssey Thermal Emission Imaging System (THEMIS) has discovered water ice exposed near the edge of Mars' southern perennial polar cap. The surface H2O ice was first observed by THEMIS as a region that was cooler than expected for dry soil at that latitude during the summer season. Diurnal and seasonal temperature trends derived from Mars Global Surveyor Thermal Emission Spectrometer observations indicate that there is H2O ice at the surface. Viking observations, and the few other relevant THEMIS observations, indicate that surface H2O ice may be widespread around and under the perennial CO2 cap.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Titus, Timothy N -- Kieffer, Hugh H -- Christensen, Phillip R -- New York, N.Y. -- Science. 2003 Feb 14;299(5609):1048-51. Epub 2002 Dec 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Branch of Astrogeology, U.S. Geological Survey, 2255 North Gemini Drive, Flagstaff, AZ 86001, USA. ttitus@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471268" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Dry Ice ; Extraterrestrial Environment ; *Ice ; *Mars ; Seasons ; Temperature ; *Water
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  • 66
    Publication Date: 2002-06-01
    Description: Global distributions of thermal, epithermal, and fast neutron fluxes have been mapped during late southern summer/northern winter using the Mars Odyssey Neutron Spectrometer. These fluxes are selectively sensitive to the vertical and lateral spatial distributions of H and CO2 in the uppermost meter of the martian surface. Poleward of +/-60 degrees latitude is terrain rich in hydrogen, probably H2O ice buried beneath tens of centimeter-thick hydrogen-poor soil. The central portion of the north polar cap is covered by a thick CO2 layer, as is the residual south polar cap. Portions of the low to middle latitudes indicate subsurface deposits of chemically and/or physically bound H2O and/or OH.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, W C -- Boynton, W V -- Tokar, R L -- Prettyman, T H -- Gasnault, O -- Squyres, S W -- Elphic, R C -- Lawrence, D J -- Lawson, S L -- Maurice, S -- McKinney, G W -- Moore, K R -- Reedy, R C -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):75-8. Epub 2002 May 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Los Alamos National Laboratory, Los Alamos, NM 87545, USA. wfeldman@lanl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040088" target="_blank"〉PubMed〈/a〉
    Keywords: Dry Ice ; Extraterrestrial Environment ; Gamma Rays ; *Hydrogen ; Ice ; *Mars ; *Neutrons ; Spacecraft ; Spectrometry, Gamma ; Spectrum Analysis ; Temperature ; Water
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  • 67
    Publication Date: 2002-08-24
    Description: Climate influences a variety of ecological processes. These effects operate through local weather parameters such as temperature, wind, rain, snow, and ocean currents, as well as interactions among these. In the temperate zone, local variations in weather are often coupled over large geographic areas through the transient behavior of atmospheric planetary-scale waves. These variations drive temporally and spatially averaged exchanges of heat, momentum, and water vapor that ultimately determine growth, recruitment, and migration patterns. Recently, there have been several studies of the impact of large-scale climatic forcing on ecological systems. We review how two of the best-known climate phenomena-the North Atlantic Oscillation and the El Nino-Southern Oscillation-affect ecological patterns and processes in both marine and terrestrial systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stenseth, Nils Chr -- Mysterud, Atle -- Ottersen, Geir -- Hurrell, James W -- Chan, Kung-Sik -- Lima, Mauricio -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1292-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Division of Zoology, University of Oslo, Post Office Box 1050 Blindern, N-0316 Oslo, Norway. n.c.stenseth@bio.uio.no〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193777" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Climate ; *Ecosystem ; Fishes/physiology ; Food Chain ; Geography ; Plankton/physiology ; Population Dynamics ; Seawater ; Temperature ; Weather
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  • 68
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, Giselle -- New York, N.Y. -- Science. 2002 Jul 5;297(5578):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12098675" target="_blank"〉PubMed〈/a〉
    Keywords: Acrylamide/*adverse effects/*analysis/metabolism ; Advisory Committees ; Animals ; *Carcinogens/analysis ; *Cooking ; *Food ; Food Analysis ; Humans ; Neurons/metabolism ; Protein Binding ; Proteins/metabolism ; Temperature ; World Health Organization
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  • 69
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-24
    Description: The mane of the African lion (Panthera leo) is a highly variable trait that reflects male condition and ambient temperature. We examined the consequences of this variation in a long-term study of lions in the Serengeti National Park, Tanzania. Mane darkness indicates nutrition and testosterone and influences both female choice and male-male competition. Mane length signals fighting success and only appears to influence male-male assessment. Dark-maned males enjoy longer reproductive life-spans and higher offspring survival, but they suffer higher surface temperatures, abnormal sperm, and lower food intake during hot months of the year. Maned males are hotter than females, and males have lighter and/or shorter manes in hotter seasons, years, and habitats. This phenotypic plasticity suggests that the mane will respond to forecasted increases in ambient temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉West, Peyton M -- Packer, Craig -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1339-43.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology, Evolution and Behavior, University of Minnesota, 1987 Upper Buford Circle, St. Paul, MN 55108, USA. west0302@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193785" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animal Nutritional Physiological Phenomena ; Animals ; *Behavior, Animal ; Biological Evolution ; Body Temperature ; Body Temperature Regulation ; Climate ; Environment ; Female ; *Hair/anatomy & histology/growth & development ; Hair Color ; Hot Temperature ; Lions/*anatomy & histology/*physiology ; Male ; Seasons ; Sex Characteristics ; *Sexual Behavior, Animal ; Spermatozoa/abnormalities ; Tanzania ; Temperature ; Testosterone/blood
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  • 70
    Publication Date: 2002-03-09
    Description: The strontium-to-calcium ratio (Sr/Ca) of reef coral skeleton is commonly used as a paleothermometer to estimate sea surface temperatures (SSTs) at crucial times in Earth's climate history. However, these estimates are disputed, because uptake of Sr into coral skeleton is thought to be affected by algal symbionts (zooxanthellae) living in the host tissue. Here, we show that significant distortion of the Sr/Ca temperature record in coral skeleton occurs in the presence of algal symbionts. Seasonally resolved Sr/Ca in coral without symbionts reflects local SSTs with a temperature sensitivity equivalent to that of laboratory aragonite precipitated at equilibrium and the nighttime skeletal deposits of symbiotic reef corals. However, up to 65% of the Sr/Ca variability in symbiotic skeleton is related to symbiont activity and does not reflect water temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Anne L -- Owens, Kathryn E -- Layne, Graham D -- Shimizu, Nobumichi -- New York, N.Y. -- Science. 2002 Apr 12;296(5566):331-3. Epub 2002 Mar 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology and Geophysics, Woods Hole Oceanographic Institution (WHOI), Woods Hole, MA 02543, USA. acohen@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11884719" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Calcium/analysis ; Calcium Carbonate/*chemistry ; *Climate ; Cnidaria/*chemistry/growth & development/physiology ; Eukaryota/*physiology ; Photosynthesis ; Seasons ; *Seawater ; Strontium/analysis ; *Symbiosis ; Temperature ; Time
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  • 71
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-06-01
    Description: The average first flowering date of 385 British plant species has advanced by 4.5 days during the past decade compared with the previous four decades: 16% of species flowered significantly earlier in the 1990s than previously, with an average advancement of 15 days in a decade. Ten species (3%) flowered significantly later in the 1990s than previously. These data reveal the strongest biological signal yet of climatic change. Flowering is especially sensitive to the temperature in the previous month, and spring-flowering species are most responsive. However, large interspecific differences in this response will affect both the structure of plant communities and gene flow between species as climate warms. Annuals are more likely to flower early than congeneric perennials, and insect-pollinated species more than wind-pollinated ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fitter, A H -- Fitter, R S R -- New York, N.Y. -- Science. 2002 May 31;296(5573):1689-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of York, York YO10 5DD, UK. ahf1@york.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040195" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Ecosystem ; England ; Geography ; Phylogeny ; *Plant Physiological Phenomena ; Plant Structures/*physiology ; Plants/classification ; Pollen ; Seasons ; Temperature ; Time Factors
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  • 72
    Publication Date: 2002-11-09
    Description: Methods of risk assessment for alien species, especially for nonagricultural systems, are largely qualitative. Using a generalizable risk assessment approach and statistical models of fish introductions into the Great Lakes, North America, we developed a quantitative approach to target prevention efforts on species most likely to cause damage. Models correctly categorized established, quickly spreading, and nuisance fishes with 87 to 94% accuracy. We then identified fishes that pose a high risk to the Great Lakes if introduced from unintentional (ballast water) or intentional pathways (sport, pet, bait, and aquaculture industries).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolar, Cynthia S -- Lodge, David M -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1233-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. ckolar@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424378" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Analysis of Variance ; Animals ; Conservation of Natural Resources ; Discriminant Analysis ; *Ecology ; *Ecosystem ; *Environment ; *Fishes/growth & development/physiology ; Forecasting ; Models, Biological ; *Models, Statistical ; Multivariate Analysis ; Regression Analysis ; Risk Assessment ; Seawater ; Sodium Chloride ; Temperature
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  • 73
    Publication Date: 2002-08-06
    Description: A record of foraminiferal shell weight across glacial-interglacial Termination I shows a response related to seawater carbonate ion concentration and allows reconstruction of a record of carbon dioxide in surface seawater that matches the atmospheric record. The results support suggestions that higher atmospheric carbon dioxide directly affects marine calcification, an effect that may be of global importance to past and future changes in atmospheric CO2. The process provides negative feedback to the influence of marine calcification on atmospheric carbon dioxide and is of practical importance to the application of paleoceanographic proxies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, Stephen -- Elderfield, Henry -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):833-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth Sciences, University of Cambridge, Cambridge CB2 3EQ, UK. sbar98@esc.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; Atmosphere/*chemistry ; *Calcification, Physiologic ; Calcium/analysis ; Calcium Carbonate/metabolism ; Calibration ; Carbon Dioxide/*metabolism ; Carbonic Acid/metabolism ; Cnidaria/metabolism ; Hydrogen-Ion Concentration ; *Ice ; Magnesium/analysis ; Plankton/*metabolism ; Seawater/chemistry ; Sodium/analysis ; Solubility ; Temperature
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  • 74
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-10
    Description: Synthetic polymers offer a wealth of opportunities to design responsive materials triggered by external stimuli. Changing the length, chemical composition, architecture, and topology of the chains allows response mechanisms and rates to be easily manipulated; and devices based on the entropy of the chains, surface energies, and specific segmental interactions can readily be made. Although numerous applications exist, intriguing possibilities are emerging that have tremendous potential to further developments in surface-responsive materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, T P -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):964-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Polymer Science and Engineering Department, University of Massachusetts, Amherst, MA 01003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169722" target="_blank"〉PubMed〈/a〉
    Keywords: *Biocompatible Materials/chemistry ; Chemistry, Physical ; *Elastomers/chemistry ; Entropy ; Light ; Nanotechnology ; Physicochemical Phenomena ; *Polymers/chemistry ; Surface Properties ; Temperature ; Water
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  • 75
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-05-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, Malcolm K -- New York, N.Y. -- Science. 2002 May 3;296(5569):848-9 author reply 848-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11989486" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; Temperature ; Time Factors ; Trees/growth & development/*physiology
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  • 76
    Publication Date: 2002-06-01
    Description: A biogeochemical model of vegetation using observed climate data predicts the high northern latitude greening trend over the past two decades observed by satellites and a marked setback in this trend after the Mount Pinatubo volcano eruption in 1991. The observed trend toward earlier spring budburst and increased maximum leaf area is produced by the model as a consequence of biogeochemical vegetation responses mainly to changes in temperature. The post-Pinatubo decline in vegetation in 1992-1993 is apparent as the effect of temporary cooling caused by the eruption. High-latitude CO(2) uptake during these years is predicted as a consequence of the differential response of heterotrophic respiration and net primary production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lucht, Wolfgang -- Prentice, I Colin -- Myneni, Ranga B -- Sitch, Stephen -- Friedlingstein, Pierre -- Cramer, Wolfgang -- Bousquet, Philippe -- Buermann, Wolfgang -- Smith, Benjamin -- New York, N.Y. -- Science. 2002 May 31;296(5573):1687-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Potsdam Institute for Climate Impact Research, Post Office Box 601203, D-14412 Potsdam, Germany. Wolfgang.Lucht@pik-potsdam.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040194" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Biomass ; Carbon Dioxide/metabolism ; *Climate ; Computer Simulation ; *Ecosystem ; Geography ; Models, Biological ; *Plant Development ; Plant Leaves/*growth & development ; Seasons ; Temperature ; *Volcanic Eruptions
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  • 77
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1866.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471228" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Climate ; Extraterrestrial Environment ; *Mars ; *Minor Planets ; Rain ; Temperature ; *Water
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  • 78
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-04-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2002 Apr 19;296(5567):454-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11964456" target="_blank"〉PubMed〈/a〉
    Keywords: Alaska ; Animals ; *Archaeology ; Canada ; DNA/analysis ; Humans ; *Ice ; Mummies ; *Paleontology ; Plants ; Temperature ; Yukon Territory
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  • 79
    Publication Date: 2002-06-01
    Description: We provide evidence of large-scale changes in the biogeography of calanoid copepod crustaceans in the eastern North Atlantic Ocean and European shelf seas. We demonstrate that strong biogeographical shifts in all copepod assemblages have occurred with a northward extension of more than 10 degrees latitude of warm-water species associated with a decrease in the number of colder-water species. These biogeographical shifts are in agreement with recent changes in the spatial distribution and phenology detected for many taxonomic groups in terrestrial European ecosystems and are related to both the increasing trend in Northern Hemisphere temperature and the North Atlantic Oscillation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beaugrand, Gregory -- Reid, Philip C -- Ibanez, Frederic -- Lindley, J Alistair -- Edwards, Martin -- New York, N.Y. -- Science. 2002 May 31;296(5573):1692-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sir Alister Hardy Foundation for Ocean Science, The Laboratory Citadel Hill, Plymouth PL1 2PB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12040196" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atlantic Ocean ; *Climate ; *Crustacea ; *Ecosystem ; Geography ; Principal Component Analysis ; Seasons ; *Seawater ; Temperature ; *Zooplankton
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krishnan, Madhavi -- Ugaz, Victor M -- Burns, Mark A -- P01 HG01984-01/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):793.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109-2136, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399582" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/genetics ; Convection ; Dna ; Humans ; Polymerase Chain Reaction/*instrumentation/methods ; Temperature
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  • 81
    Publication Date: 2002-08-17
    Description: COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases. The Jab1/MPN domain metalloenzyme (JAMM) motif in the Jab1/Csn5 subunit was found to underlie CSN's Nedd8 isopeptidase activity. JAMM is found in proteins from archaea, bacteria, and eukaryotes, including the Rpn11 subunit of the 26S proteasome. Metal chelators and point mutations within JAMM abolished CSN-dependent cleavage of Nedd8 from Cul1, yet had little effect on CSN complex assembly. Optimal SCF activity in yeast and both viability and proper photoreceptor cell (R cell) development in Drosophila melanogaster required an intact Csn5 JAMM domain. We propose that JAMM isopeptidases play important roles in a variety of physiological pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cope, Gregory A -- Suh, Greg S B -- Aravind, L -- Schwarz, Sylvia E -- Zipursky, S Lawrence -- Koonin, Eugene V -- Deshaies, Raymond J -- New York, N.Y. -- Science. 2002 Oct 18;298(5593):608-11. Epub 2002 Aug 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, California Institute of Technology (CalTech), Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12183637" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Carbon-Nitrogen Lyases/metabolism ; Cell Cycle Proteins/*metabolism ; *Cullin Proteins ; DNA-Binding Proteins/*chemistry/*metabolism ; Drosophila Proteins ; Drosophila melanogaster/growth & development/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Metalloendopeptidases/*chemistry/genetics/*metabolism ; Molecular Sequence Data ; Mutation ; Peptide Hydrolases ; Peptide Synthases/metabolism ; SKP Cullin F-Box Protein Ligases ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry/genetics/metabolism ; Schizosaccharomyces/genetics/metabolism ; Sequence Alignment ; Temperature ; Transcription Factors/*chemistry/*metabolism ; Ubiquitins/*metabolism
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