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  • 1
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    The unexpected surface of asteroid (101955) Bennu (2019)
    Springer Nature
    In: Nature
    Details
    Publication Date: 2019
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code (2012)
    Oxford University Press
    Details
    Publication Date: 2012-06-06
    Description: Helicobacter pylori catalyzes Asn-tRNA Asn formation by use of the indirect pathway that involves charging of Asp onto tRNA Asn by a non-discriminating aspartyl-tRNA synthetase (ND-AspRS), followed by conversion of the mischarged Asp into Asn by the GatCAB amidotransferase. We show that the partners of asparaginylation assemble into a dynamic Asn-transamidosome, which uses a different strategy than the Gln-transamidosome to prevent the release of the mischarged aminoacyl-tRNA intermediate. The complex is described by gel-filtration, dynamic light scattering and kinetic measurements. Two strategies for asparaginylation are shown: (i) tRNA Asn binds GatCAB first, allowing aminoacylation and immediate transamidation once ND-AspRS joins the complex; (ii) tRNA Asn is bound by ND-AspRS which releases the Asp-tRNA Asn product much slower than the cognate Asp-tRNA Asp ; this kinetic peculiarity allows GatCAB to bind and transamidate Asp-tRNA Asn before its release by the ND-AspRS. These results are discussed in the context of the interrelation between the Asn and Gln-transamidosomes which use the same GatCAB in H. pylori , and shed light on a kinetic mechanism that ensures faithful codon reassignment for Asn.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Observations of comet 19P/Borrelly by the miniature integrated camera and spectrometer aboard Deep Space 1 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-06
    Description: The nucleus of the Jupiter-family comet 19P/Borrelly was closely observed by the Miniature Integrated Camera and Spectrometer aboard the Deep Space 1 spacecraft on 22 September 2001. The 8-kilometer-long body is highly variegated on a scale of 200 meters, exhibiting large albedo variations (0.01 to 0.03) and complex geologic relationships. Short-wavelength infrared spectra (1.3 to 2.6 micrometers) show a slope toward the red and a hot, dry surface (〈/=345 kelvin, with no trace of water ice or hydrated minerals), consistent with approximately 10% or less of the surface actively sublimating. Borrelly's coma exhibits two types of dust features: fans and highly collimated jets. At encounter, the near-nucleus coma was dominated by a prominent dust jet that resolved into at least three smaller jets emanating from a broad basin in the middle of the nucleus. Because the major dust jet remained fixed in orientation, it is evidently aligned near the rotation axis of the nucleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soderblom, L A -- Becker, T L -- Bennett, G -- Boice, D C -- Britt, D T -- Brown, R H -- Buratti, B J -- Isbell, C -- Giese, B -- Hare, T -- Hicks, M D -- Howington-Kraus, E -- Kirk, R L -- Lee, M -- Nelson, R M -- Oberst, J -- Owen, T C -- Rayman, M D -- Sandel, B R -- Stern, S A -- Thomas, N -- Yelle, R V -- New York, N.Y. -- Science. 2002 May 10;296(5570):1087-91. Epub 2002 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United States Geological Survey, 2255 North Gemini Drive, Flagstaff, AZ 86001, USA. lsoderblom@usgs.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11934989" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon/analysis ; Cosmic Dust ; Hydrocarbons/analysis ; *Meteoroids ; Spectrum Analysis ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Triton's Geyser-Like Plumes: Discovery and Basic Characterization (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-10-19
    Description: At least four active geyser-like eruptions were discovered in Voyager 2 images of Triton, Neptune's large satellite. The two best documented eruptions occur as columns of dark material rising to an altitude of about 8 kilometers where dark clouds of material are left suspended to drift downwind over 100 kilometers. The radii of the rising columns appear to be in the range of several tens of meters to a kilometer. One model for the mechanism to drive the plumes involves heating of nitrogen ice in a subsurface greenhouse environment; nitrogen gas pressurized by the solar heating explosively vents to the surface carrying clouds of ice and dark partides into the atmosphere. A temperature increase of less than 4 kelvins above the ambient surface value of 38 +/- 3 kelvins is more than adequate to drive the plumes to an 8-kilometer altitude. The mass flux in the trailing clouds is estimated to consist of up to 10 kilograms of fine dark particles per second or twice as much nitrogen ice and perhaps several hundred or more kilograms of nitrogen gas per second. Each eruption may last a year or more, during which on the order of a tenth of a cubic kilometer of ice is sublimed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soderblom, L A -- Kieffer, S W -- Becker, T L -- Brown, R H -- Cook, A F 2nd -- Hansen, C J -- Johnson, T V -- Kirk, R L -- Shoemaker, E M -- New York, N.Y. -- Science. 1990 Oct 19;250(4979):410-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17793016" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Chemical aspects of the photooxidation of the propylene-nitrogen oxide system (1967)
    s.l. : American Chemical Society
    Environmental science & technology 1 (1967), S. 899-914 
    Details
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/es60011a006
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  • 6
    Electronic Resource
    Electronic Resource
    Photooxidation of propylene with nitrogen oxide in the presence of sulfur dioxide (1968)
    s.l. : American Chemical Society
    Environmental science & technology 2 (1968), S. 696-698 
    Details
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/es60021a003
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  • 7
    Electronic Resource
    Electronic Resource
    Crystal structure of flavonoid compounds. I. 4'-Bromoflavanone (1974)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 30 (1974), S. 154-161 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740874002391
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  • 8
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    Equation Chapter 1 Section 1Role of strain-dependent weakening memory on the style of mantle convection and plate boundary stability (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉How plate tectonic surface motions relate to the convecting mantle remains one of the major problems in geosciences. In particular, the cause and consequence of strain localization at plate boundaries remains debated, even though strain memory, i.e. the ability to preserve and reactivate tectonic inheritance over geological time, appears to be a critical feature in plate tectonics. Here, we analyze how a parameterized damage weakening rheology, strain-dependent weakening, affects the time-dependence of plate boundary formation, the transition between mobile and stagnant-lid, and the reorganization of plates in 2-D convection models. The strain-dependent weakening within our models allows for a self-consistent formation and preservation of lithospheric weak zones, which are formed as remnants of subduction zones due to large-scale compressional deformation in the trench region. Such inherited weak zones can be reactivated as intra-plate subduction zones, ridge adjacent subduction, or as spreading centers themselves. Due to the weakening along plate boundaries, the inherited weak zones, and partly the accumulated strain along spreading centers, which weakens the shallow parts of the lithosphere, the longevity of mobile-lid convection increases. Strain-dependent weakening also enhances strain localization along convergent plate boundaries which increases their stability and longevity. As a consequence, tectonic inheritance is an important contribution to understanding the time-dependence of plate reorganization. Strain-dependent weakening results in a shift of the mobile-stagnant lid transition to higher effective yield stresses, if the weak zones fully penetrate the lithosphere and are relatively weakened by at least 20 per cent.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 9
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    Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-29
    Description: Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by mutations in the dystrophin gene. The subcellular mechanisms of DMD remain poorly understood and there is currently no curative treatment available. Using a Caenorhabditis elegans model for DMD as a pharmacologic and genetic tool, we found that cyclosporine A (CsA) reduces muscle degeneration at low dose and acts, at least in part, through a mitochondrial cyclophilin D, CYN-1. We thus hypothesized that CsA acts on mitochondrial permeability modulation through cyclophilin D inhibition. Mitochondrial patterns and dynamics were analyzed, which revealed dramatic mitochondrial fragmentation not only in dystrophic nematodes, but also in a zebrafish model for DMD. This abnormal mitochondrial fragmentation occurs before any obvious sign of degeneration can be detected. Moreover, we demonstrate that blocking/delaying mitochondrial fragmentation by knocking down the fission-promoting gene drp-1 reduces muscle degeneration and improves locomotion abilities of dystrophic nematodes. Further experiments revealed that cytochrome c is involved in muscle degeneration in C. elegans and seems to act, at least in part, through an interaction with the inositol trisphosphate receptor calcium channel, ITR-1. Altogether, our findings reveal that mitochondria play a key role in the early process of muscle degeneration and may be a target of choice for the design of novel therapeutics for DMD. In addition, our results provide the first indication in the nematode that (i) mitochondrial permeability transition can occur and (ii) cytochrome c can act in cell death.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 10
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    Role of strain-dependent weakening memory on the style of mantle convection and plate boundary stability (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉SUMMARY〈/div〉How plate tectonic surface motions relate to the convecting mantle remains one of the major problems in geosciences. In particular, the cause and consequence of strain localization at plate boundaries remains debated, even though strain memory, that is, the ability to preserve and reactivate tectonic inheritance over geological time, appears to be a critical feature in plate tectonics. Here, we analyse how a parametrized damage weakening rheology, strain-dependent weakening, affects the time-dependence of plate boundary formation, the transition between mobile and stagnant-lid and the reorganization of plates in 2-D convection models. The strain-dependent weakening within our models allows for a self-consistent formation and preservation of lithospheric weak zones, which are formed as remnants of subduction zones due to large-scale compressional deformation in the trench region. Such inherited weak zones can be reactivated as intraplate subduction zones, ridge adjacent subduction or as spreading centres themselves. Due to the weakening along plate boundaries, the inherited weak zones, and partly the accumulated strain along spreading centres, which weakens the shallow parts of the lithosphere, the longevity of mobile-lid convection increases. Strain-dependent weakening also enhances strain localization along convergent plate boundaries which increases their stability and longevity. As a consequence, tectonic inheritance is an important contribution to understanding the time-dependence of plate reorganization. Strain-dependent weakening results in a shift of the mobile-stagnant lid transition to higher effective yield stresses, if the weak zones fully penetrate the lithosphere and are relatively weakened by at least 20 per cent.〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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