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  • Cell & Developmental Biology  (873)
  • Inorganic Chemistry  (785)
  • Humans
  • 1990-1994
  • 1985-1989  (2,011)
  • 1945-1949
  • 1985  (2,011)
Collection
Keywords
Publisher
Years
  • 1990-1994
  • 1985-1989  (2,011)
  • 1945-1949
Year
  • 101
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    Food dyes fuel debate over Delaney (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):739-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023708" target="_blank"〉PubMed〈/a〉
    Keywords: Food Coloring Agents/*standards ; Humans ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 102
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    Gene therapy guidelines approved (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3863254" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; DNA, Recombinant/*therapeutic use ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Generic Valiums clear another hurdle at FDA (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):369.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012323" target="_blank"〉PubMed〈/a〉
    Keywords: *Diazepam ; Humans ; Therapeutic Equivalency ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Illinois traces cause of Salmonella outbreak (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 May 24;228(4702):972-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3839094" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disease Outbreaks ; Humans ; Illinois ; Milk/*microbiology ; Salmonella Food Poisoning/epidemiology/*etiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    Desperately seeking Salmonella in Illinois (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 May 17;228(4701):829-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3890177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chicago ; Dairying ; Disease Outbreaks ; Humans ; Milk/*microbiology ; Salmonella Food Poisoning/*epidemiology/etiology ; Salmonella typhimurium/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 106
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    The vexing problems of vaccine compensation (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1012-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975597" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Compensation and Redress ; Federal Government ; Humans ; *Legislation, Medical ; Risk Assessment ; United States ; *Vaccines/adverse effects ; children who are injured by vaccines administered as part of the public health ; campaign against childhood diseases. Blaming increased liability costs, several ; drug companies have stopped production of essential vaccines, raising fears of ; shortages. Proposals that the federal government sponsor a compensation system ; have met with approval from parents of injured children, medical associations, ; and drug companies, although these groups disagree over whether victims should ; retain the right to sue the vaccine manufacturers as an alternative to receiving ; federal compensation. Legislation has been introduced in both houses of Congress ; to establish a compensation program, but Administration opposition is expected to ; the potential expense and the broad range of coverage.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Agency scraps plan to limit ethylene oxide (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):392-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966156" target="_blank"〉PubMed〈/a〉
    Keywords: *Ethylene Oxide/adverse effects ; Humans ; Maximum Allowable Concentration ; Time Factors ; United States ; United States Occupational Safety and Health Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 108
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    Whooping cough vaccine research revs up (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1985 Mar 8;227(4691):1184-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2858128" target="_blank"〉PubMed〈/a〉
    Keywords: Bordetella pertussis ; Child ; Humans ; *Pertussis Vaccine ; Whooping Cough/prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 109
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    A sexually dimorphic nucleus in the human brain (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-31
    Description: A sexually dimorphic cell group is described in the preoptic area of the human hypothalamus. Morphometric analysis revealed that the volume of this nucleus is 2.5 +/- 0.6 times (mean +/- standard error of the mean) as large in men as in women, and contains 2.2 +/- 0.5 times as many cells. Between the ages of 10 and 93 years, the nucleus decreases greatly in volume and in cell number. Although no function has yet been established for this nucleus, it is located within an area that is essential for gonadotropin release and sexual behavior in other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swaab, D F -- Fliers, E -- New York, N.Y. -- Science. 1985 May 31;228(4703):1112-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3992248" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Preoptic Area/*anatomy & histology/cytology ; *Sex Characteristics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 110
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    New directions for the IOM. Interview by Gina Kolata (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thier, S -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):524.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048945" target="_blank"〉PubMed〈/a〉
    Keywords: Delivery of Health Care ; Humans ; *National Academy of Sciences (U.S.) ; *Organizations ; Physicians ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 111
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    Neurotrophic factors (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-19
    Description: In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thoenen, H -- Edgar, D -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):238-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409599" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cattle ; Cell Survival ; Cells, Cultured ; Chick Embryo ; Chickens ; Cyclic AMP/physiology ; DNA/genetics ; Extracellular Matrix/physiology ; Humans ; Ion Channels/physiology ; Male ; Mice ; Molecular Weight ; Myocardium/cytology ; Nerve Growth Factors/genetics/isolation & purification/*physiology ; Neurons/physiology ; Protein Precursors/genetics ; RNA, Messenger/metabolism ; Rats ; Receptors, Cell Surface/physiology ; Receptors, Nerve Growth Factor ; Sympathetic Nervous System/cytology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 112
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    Bovine leukemia virus-related antigens in lymphocyte cultures infected with AIDS-associated viruses (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-22
    Description: An earlier finding that lymphocytes from African patients with the acquired immune deficiency syndrome (AIDS) react with rabbit antiserum to purified antigens of bovine leukemia virus (BLV) prompted a study of the possible cross-reactions between a BLV-infected ovine cell line and human lymphocytes inoculated with a strain of lymphadenopathy syndrome-associated virus (LAV). A solid-phase radioimmunoassay was used to detect antigenic markers of the retroviruses. Crude extracts from short-term cultures of lymphocytes infected with LAV bound rabbit antisera to the LAV glycoprotein gp13 (molecular weight 13,000) and the BLV proteins p24 and gp51, but did not bind antibodies to the p24 of human T-cell leukemia virus type I (HTLV-I). Antiserum to LAV gp13 reacted with an ovine cell line producing BLV but also weakly with virus-free ovine cells. Lymphocyte cultures from four African patients with AIDS expressed BLV-related antigens within 6 to 10 days of culture, at the moment when particle-bound reverse transcriptase was produced. BLV-related antigens were induced in lymphocyte cultures from healthy individuals by addition of filtered supernatant or irradiated cells of the original culture. The antisera to BLV used in this study may prove useful for the detection of AIDS-associated viruses in short-term cultures of lymphocytes from AIDS patients or their contacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thiry, L -- Sprecher-Goldberger, S -- Jacquemin, P -- Cogniaux, J -- Burny, A -- Bruck, C -- Portetelle, D -- Cran, S -- Clumeck, N -- New York, N.Y. -- Science. 1985 Mar 22;227(4693):1482-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2579433" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Animals ; Antigens, Viral/analysis/*immunology ; Cell Line ; Cells, Cultured ; Cross Reactions ; Deltaretrovirus/*immunology ; Epitopes/immunology ; Humans ; Leukemia Virus, Bovine/*immunology ; Lymph Nodes/microbiology ; Lymphocytes/immunology/*microbiology ; Radioimmunoassay ; Retroviridae/*immunology ; Sheep ; Viral Proteins/immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Knowledge without awareness: an autonomic index of facial recognition by prosopagnosics (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-21
    Description: Prosopagnosia, the inability to recognize visually the faces of familiar persons who continue to be normally recognized through other sensory channels, is caused by bilateral cerebral lesions involving the visual system. Two patients with prosopagnosia generated frequent and large electrodermal skin conductance responses to faces of persons they had previously known but were now unable to recognize. They did not generate such responses to unfamiliar faces. The results suggest that an early step of the physiological process of recognition is still taking place in these patients, without their awareness but with an autonomic index.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tranel, D -- Damasio, A R -- NS 19632-02/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1453-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012303" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Agnosia/*physiopathology ; *Awareness ; *Cognition ; *Face ; Female ; Galvanic Skin Response ; Humans ; Middle Aged ; *Visual Perception
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    HTLV x-gene product: requirement for the env methionine initiation codon (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-28
    Description: The human T-cell leukemia viruses (HTLV) are replication-competent retroviruses whose genomes contain gag, pol, and env genes as well as a fourth gene, termed x, which is believed to be the transforming gene of HTLV. The product of the x gene is now shown to be encoded by a 2.1-kilobase messenger RNA derived by splicing of at least two introns. By means of S1 nuclease mapping of this RNA and nucleic acid sequence analysis of a complementary DNA clone, the complete primary structure of the x-gene product has been determined. It is encoded by sequences containing the env initiation codon and one nucleotide of the next codon spliced to the major open reading frame of the HTLV-I and HTLV-II x gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wachsman, W -- Golde, D W -- Temple, P A -- Orr, E C -- Clark, S C -- Chen, I S -- CA 30388/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- CA 38597/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1534-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990032" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Transformation, Viral ; Codon ; Deltaretrovirus/*genetics ; Electrophoresis, Polyacrylamide Gel ; Humans ; Methionine/*genetics ; Rats ; Viral Proteins/*analysis
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 115
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    Identification of human glucocorticoid receptor complementary DNA clones by epitope selection (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-10
    Description: Steroid hormones regulate cellular differentiation and physiologic functions predominantly through gene transcription. Regulation is achieved by the interaction of specific steroid receptor proteins and target genes. Expression cloning techniques were used to select human glucocorticoid receptor complementary DNA clones in order to define the mechanism by which the receptor exerts its transcriptional control. Immobilized fusion proteins from individual clones were used to select epitope-specific antibody which was subsequently eluted and identified by binding to protein blots of cellular extracts. Three cross-hybridizing clones containing inserts expressing antigenic determinants of the human glucocorticoid receptor were isolated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberger, C -- Hollenberg, S M -- Ong, E S -- Harmon, J M -- Brower, S T -- Cidlowski, J -- Thompson, E B -- Rosenfeld, M G -- Evans, R M -- New York, N.Y. -- Science. 1985 May 10;228(4700):740-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2581314" target="_blank"〉PubMed〈/a〉
    Keywords: *Cloning, Molecular ; DNA/*genetics ; DNA, Recombinant/metabolism ; Epitopes/*genetics/immunology ; Humans ; Receptors, Glucocorticoid/*genetics/immunology ; Receptors, Steroid/*genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
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  • 116
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    Oxidative autoactivation of latent collagenase by human neutrophils (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-15
    Description: The pathological destruction of collagen plays a key role in the development of inflammatory disease states affecting every organ system in the human body. Neutrophils localized at inflammatory sites can potentially degrade collagen by releasing a metalloenzyme, collagenase, which is stored in a latent inactive form. Triggered human neutrophils were shown to release and simultaneously activate their latent collagenase. The activation of the latent enzyme was coupled to an oxidative process that required the generation of a highly reactive oxygen metabolite, hypochlorous acid. Oxidative regulation of latent collagenase activity may be important in the pathogenesis of connective tissue damage in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, S J -- Peppin, G -- Ortiz, X -- Ragsdale, C -- Test, S T -- 1 F32 AM07477/AM/NIADDK NIH HHS/ -- AI-21301/AI/NIAID NIH HHS/ -- R01 HL-28024/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1985 Feb 15;227(4688):747-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2982211" target="_blank"〉PubMed〈/a〉
    Keywords: Enzyme Activation ; Granulomatous Disease, Chronic/enzymology ; Humans ; Hydrogen Peroxide ; Hypochlorous Acid ; Microbial Collagenase/*metabolism ; Neutrophils/*enzymology ; Oxidation-Reduction ; Peroxidase/metabolism
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  • 117
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    Phagocytes as carcinogens: malignant transformation produced by human neutrophils (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-08
    Description: In a study of the relation between chronic inflammation and carcinogenesis, C3H mouse fibroblasts of the 10T 1/2 clone 8 line (10T 1/2 cells) were exposed to human neutrophils stimulated to synthesize reactive oxygen intermediates or to a cell-free enzymatic system generating superoxide (xanthine oxidase plus hypoxanthine). After exposure, the 10T 1/2 cells were either placed in tissue culture or immediately injected into athymic nude mice. Both malignant and benign tumors developed in the mice injected with treated cells, but not in those injected with control cells; in one instance cells grown from one of the benign tumors subsequently developed a malignant phenotype. Malignant transformation was also observed in treated cells in the experiments in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weitzman, S A -- Weitberg, A B -- Clark, E P -- Stossel, T P -- CA 00962/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 8;227(4691):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975611" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Neoplastic/*immunology ; Humans ; Mice ; Mice, Inbred C3H ; Mice, Nude ; Neutrophils/metabolism/*physiology ; Oxidation-Reduction/drug effects ; Phagocytes/*physiology ; Tetradecanoylphorbol Acetate/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 118
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    Distinct monoamine oxidase A and B populations in primate brain (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-11
    Description: Monoclonal antibodies specific for monoamine oxidase (MAO) A and MAO B, respectively, were used to localize these enzymes in primate brain. The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. These data illustrate the physiological independence of MAO A and B and show that neurons may be specialized for their degradative as well as their synthetic functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Westlund, K N -- Denney, R M -- Kochersperger, L M -- Rose, R M -- Abell, C W -- MH34757/MH/NIMH NIH HHS/ -- NS07309/NS/NINDS NIH HHS/ -- NS19543/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Oct 11;230(4722):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3875898" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Antibodies, Monoclonal/immunology ; Brain/drug effects/*enzymology ; Brain Stem/enzymology ; Humans ; Macaca fascicularis ; Mice/immunology ; Monoamine Oxidase/immunology/*metabolism ; Neurons/enzymology ; Paraventricular Hypothalamic Nucleus/enzymology ; Pyridines/pharmacology ; Raphe Nuclei/enzymology ; Rats ; Serotonin/physiology ; Substantia Nigra/enzymology
    Print ISSN: 0036-8075
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  • 119
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    Human immunoglobulin D: genomic sequence of the delta heavy chain (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-10
    Description: The DNA coding for the human immunoglobulin D(IgD) heavy chain (delta, delta) has been sequenced including the membrane and secreted termini. Human delta, like that of the mouse, has a separate exon for the carboxyl terminus of the secreted form. This feature of human and mouse IgD distinguishes it from all other immunoglobulins regardless of species or class. The human gene is different from that of the mouse; it has three, rather than two, constant region domains; and its lengthy hinge is encoded by two exons rather than one. Except for the third constant region, the human and mouse genes are only distantly related.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, M B -- Shen, A L -- Word, C J -- Tucker, P W -- Blattner, F R -- AI18016/AI/NIAID NIH HHS/ -- CA31013-04/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 May 10;228(4700):733-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3922054" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Humans ; Immunoglobulin D/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin delta-Chains/*genetics ; Lymphocytes/metabolism ; Mice ; RNA, Messenger/genetics ; Species Specificity
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    Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-06
    Description: A complementary DNA library was constructed from messenger RNA's extracted from the brains of mice infected with the scrapie agent. The library was differentially screened with the objectives of finding clones that might be used as markers of infection and finding clones of genes whose increased expression might be correlated with the pathological changes common to scrapie and Alzheimer's disease. A gene was identified whose expression is increased in scrapie. The complementary DNA corresponding to this gene hybridized preferentially and focally to cells in the brains of scrapie-infected animals. The cloned DNA also hybridized to the neuritic plaques found with increased frequency in brains of patients with Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wietgrefe, S -- Zupancic, M -- Haase, A -- Chesebro, B -- Race, R -- Frey, W 2nd -- Rustan, T -- Friedman, R L -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3840915" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/*genetics/pathology ; Animals ; Brain/*metabolism/pathology ; Cloning, Molecular ; Cricetinae ; DNA/genetics ; Humans ; Mice ; Nucleic Acid Hybridization ; RNA, Messenger/genetics ; Scrapie/*genetics/pathology ; Sheep
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Auditory responses in avian vocal motor neurons: a motor theory for song perception in birds (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-19
    Description: The hypoglossal motor neurons that innervate the vocal organ (syrinx) of the male zebra finch show a selective, long-latency (50-millisecond) response to sound. This response is eliminated by lesions to forebrain song-control nuclei. Different song syllables elicit a response from different syringeal motor neurons. Conspecific vocalizations may therefore be perceived as members of a set of vocal gestures and thus distinct from other environmental sounds. This hypothesis is an avian parallel to the motor theory of speech perception in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, H -- Nottebohm, F -- 5 R01 NS17991/NS/NINDS NIH HHS/ -- 507 RR07065/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):279-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012321" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Birds/*physiology ; Female ; Humans ; Hypoglossal Nerve/physiology ; Male ; Models, Neurological ; Motor Neurons/*physiology ; Sex Characteristics ; Vocalization, Animal/*physiology
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    Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-08
    Description: The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Williams, R C -- Jeffcoat, M K -- Kaplan, M L -- Goldhaber, P -- Johnson, H G -- Wechter, W J -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):640-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969553" target="_blank"〉PubMed〈/a〉
    Keywords: Alveolar Process/drug effects/physiology ; Animals ; Bone Resorption/*drug effects ; Dogs ; Female ; Flurbiprofen/*pharmacology/therapeutic use ; Humans ; Periodontal Diseases/drug therapy ; Propionates/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-22
    Description: Several inherited disorders in humans and in rodents result in myelin dysgenesis and a deficiency of the molecular constituents of myelin. A complementary DNA to one of the two major myelin proteins, myelin proteolipid protein (also known as lipophilin), has been used with Southern blot analysis of somatic cell hybrid DNA to map the human proteolipid protein gene to the middle of the long arm of the human X chromosome (bands Xq13-Xq22) and to assign the murine proteolipid protein gene to the mouse X chromosome. Comparison of the gene maps of the human and mouse X chromosomes suggests that myelin proteolipid protein may be involved in X-linked mutations at the mouse jimpy locus and has implications for Pelizaeus-Merzbacher disease, a human inherited X-linked myelin disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willard, H F -- Riordan, J R -- New York, N.Y. -- Science. 1985 Nov 22;230(4728):940-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3840606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; DNA/genetics ; Demyelinating Diseases/*genetics ; Humans ; Mice ; Mice, Neurologic Mutants/*genetics ; Myelin Proteins/*genetics ; Proteolipids/*genetics ; Uteroglobin ; *X Chromosome
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The brain connection: the corpus callosum is larger in left-handers (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-16
    Description: The size of the midsagittal area of the human corpus callosum obtained from postmortem measurement varied with tested hand preference. The corpus callosum, the main fiber tract connecting the two cerebral hemispheres, was larger by about 0.75 square centimeter, or 11 percent, in left-handed and ambidextrous people than in those with consistent right-hand preference. The difference was present in both the anterior and posterior halves, but not in the region of the splenium itself. This callosal morphology, which varied with hand preference, may also be related to individual differences in the pattern of hemispheric functional specialization. The greater bihemispheric representation of cognitive functions in left- and mixed-handers may be associated with greater anatomical connection between the hemispheres. The naturally occurring regressive events in neurogenesis, such as neuronal cell death and axonal elimination, may be factors in the individual differences in brain morphology and in functional lateralization. Specifically, right-handers may be those with more extensive early elimination of neural components.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Witelson, S F -- N01-NS-6-2344/NS/NINDS NIH HHS/ -- R01-NS 18954/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):665-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023705" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain/anatomy & histology ; Corpus Callosum/*anatomy & histology ; Female ; *Functional Laterality ; Humans ; Male ; Middle Aged ; Organ Size ; Sex Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: Clones of complementary DNA encoding the human lymphokine known as granulocyte-macrophage colony-stimulating factor (GM-CSF) were isolated by means of a mammalian cell (monkey COS cell) expression screening system. One of these clones was used to produce recombinant GM-CSF in mammalian cells. The recombinant hematopoietin was similar to the natural product that was purified to apparent homogeneity from medium conditioned by a human T-cell line. The human T-cell GM-CSF was found to be 60 percent homologous with the GM-CSF recently cloned from murine lung messenger RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong, G G -- Witek, J S -- Temple, P A -- Wilkens, K M -- Leary, A C -- Luxenberg, D P -- Jones, S S -- Brown, E L -- Kay, R M -- Orr, E C -- New York, N.Y. -- Science. 1985 May 17;228(4701):810-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3923623" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; *Cloning, Molecular ; Colony-Stimulating Factors/biosynthesis/*genetics/isolation & purification ; *Dna ; DNA, Recombinant ; *Granulocytes ; Haplorhini ; Humans ; *Macrophages ; RNA, Messenger/genetics ; T-Lymphocytes ; Transfection
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Electrical sources in human somatosensory cortex: identification by combined magnetic and potential recordings (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-01
    Description: Magnetic fields and electrical potentials produced by neuronal activity have different properties that can be used for the identification of electrical sources in the human brain. Fields and potentials occurring 20 to 30 milliseconds after median nerve stimulation in human subjects were compared in order to investigate the sources of evoked potential components that have been attributed by different investigators to the thalamus or thalamocortical afferents, to separate radial sources in somatosensory cortex and motor cortex, or to a tangential source in somatosensory cortex. The magnetic and potential wave forms were highly similar in morphology, and their spatial distributions were centered over sensorimotor cortex, were dipolar in shape, and differed in orientation by approximately 90 degrees; distances between the minimum and maximum of the magnetic distributions were about 60 percent of those of the potential distributions. These results cannot be accounted for by thalamic sources or radial cortical sources alone, but are consistent with a tangential source in somatosensory cortex, with an additional smaller contribution from radial sources.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wood, C C -- Cohen, D -- Cuffin, B N -- Yarita, M -- Allison, T -- MH-05286/MH/NIMH NIH HHS/ -- NS-19558/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1051-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975600" target="_blank"〉PubMed〈/a〉
    Keywords: Electrophysiology ; *Evoked Potentials, Somatosensory ; Humans ; Magnetics ; Motor Cortex/physiology ; Somatosensory Cortex/*physiology ; Thalamus/physiology
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    Genomic diversity of human T-lymphotropic virus type III (HTLV-III) (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: The DNA genomes of human T-lymphotropic virus type III (HTLV-III) isolated from 18 individuals with AIDS or who were at risk for AIDS were evaluated for evidence of variation. Although all of the 18 viral DNA's hybridized throughout their entire genomes to a full-length cloned probe of the original HTLV-III isolate, each of the 18 isolates showed a different restriction enzyme pattern. The number of restriction site differences between isolates ranged from only 1 site in 23 to at least 16 sites in 31. No particular viral genotype was associated with a particular disease state and 2 of the 18 patients had evidence of concurrent infection by more than one viral genotype. Propagation of three different viral isolates in vitro for up to 9 months did not lead to detectable changes in their restriction patterns. These findings indicate that different isolates of HTLV-III comprise a spectrum of highly related but distinguishable viruses and have important implications regarding the pathogenicity of HTLV-III and attempts to develop effective diagnostic, therapeutic, and preventive measures for this virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wong-Staal, F -- Shaw, G M -- Hahn, B H -- Salahuddin, S Z -- Popovic, M -- Markham, P -- Redfield, R -- Gallo, R C -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):759-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992084" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology ; Carrier State ; Cells, Cultured ; DNA Restriction Enzymes ; Deltaretrovirus/*genetics ; Humans ; Polymorphism, Genetic
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    Memory processing of serial lists by pigeons, monkeys, and people (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-19
    Description: List memory of pigeons, monkeys, and humans was tested with lists of four visual items (travel slides for animals and kaleidoscope patterns for humans). Retention interval increases for list-item memory revealed a consistent modification of the serial-position function shape: a monotonically increasing function at the shortest interval, a U-shaped function at intermediate intervals, and a monotonically decreasing function at the longest interval. The time course of these changes was fastest for pigeons, intermediate for monkeys, and slowest for humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wright, A A -- Santiago, H C -- Sands, S F -- Kendrick, D F -- Cook, R G -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):287-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304205" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Columbidae ; Female ; Humans ; Macaca mulatta ; Male ; Random Allocation ; *Retention (Psychology) ; Serial Learning
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    Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-10
    Description: Consistent chromosomal translocations in neoplastic cells may alter the expression of proto-oncogenes that are located near the breakpoints. The complementary DNA sequence of the human insulin receptor is similar to those of the EGF receptor (erbB oncogene) and products of the src family of oncogenes. With in situ hybridization and Southern blot analysis of somatic cell hybrid DNA, the human insulin receptor gene was mapped to the distal short arm of chromosome 19 (bands p13.2----p13.3), a site involved in a nonrandom translocation in pre-B-cell acute leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yang-Feng, T L -- Francke, U -- Ullrich, A -- GM 26105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 May 10;228(4700):728-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3873110" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes ; *Chromosome Mapping ; *Chromosomes, Human, 19-20 ; Cricetinae ; Cricetulus ; Humans ; Hybrid Cells/metabolism ; Leukemia, Lymphoid/*genetics ; Nucleic Acid Hybridization ; Receptor, Insulin/*genetics ; Translocation, Genetic
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    Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-08
    Description: Transfection of normal human bronchial epithelial (NHBE) cells with a plasmid carrying the ras oncogene of Harvey murine sarcoma virus (v-Ha ras) changed the growth requirements, terminal differentiation, and tumorigenicity of the recipient cells. One of the cell lines isolated after transfection (TBE-1) was studied extensively and shown to contain v-Ha ras DNA. Total cellular RNA from TBE-1 cells hybridized to v-Ha ras structural gene fragment probes five to eight times more than RNA from parental NHBE cells. The TBE-1 cells expressed phosphorylated v-Ha ras polypeptide p21, showed a reduced requirement for growth-factor supplements, and became aneuploid as an early cellular response to v-Ha ras expression. As the transfectants acquire an indefinite life-span and anchorage independence they became transplantable tumor cells and showed many phenotypic changes suggesting a pleiotropic mechanism for the role of Ha ras in human carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoakum, G H -- Lechner, J F -- Gabrielson, E W -- Korba, B E -- Malan-Shibley, L -- Willey, J C -- Valerio, M G -- Shamsuddin, A M -- Trump, B F -- Harris, C C -- New York, N.Y. -- Science. 1985 Mar 8;227(4691):1174-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bronchi/*cytology/microbiology ; Carcinoma, Bronchogenic/genetics ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; *Cell Transformation, Viral ; Culture Media ; DNA, Neoplasm/genetics ; Epithelial Cells ; Epithelium/microbiology ; Humans ; Lung Neoplasms/genetics ; Mice ; Mice, Nude ; Nucleic Acid Hybridization ; *Oncogenes ; Rats ; *Transfection
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-24
    Description: The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J F -- Hockmeyer, W T -- Gross, M -- Ballou, W R -- Wirtz, R A -- Trosper, J H -- Beaudoin, R L -- Hollingdale, M R -- Miller, L H -- Diggs, C L -- New York, N.Y. -- Science. 1985 May 24;228(4702):958-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Formation ; Antigens, Surface/genetics/*immunology ; Carcinoma, Hepatocellular ; Cell Line ; Cloning, Molecular ; Cross Reactions ; DNA, Recombinant ; Escherichia coli/genetics ; Humans ; Liver Neoplasms ; Malaria/*prevention & control ; Mice ; Plasmodium/immunology ; Plasmodium falciparum/genetics/*immunology/physiology ; *Protozoan Proteins ; Vaccines/*immunology
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    Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-21
    Description: Protective immunity against malaria can be obtained by vaccination with irradiated sporozoites. The protective antigens known as circumsporozoite (CS) proteins, are polypeptides that cover the surface membrane of the parasite. The CS proteins contain species-specific immunodominant epitopes formed by tandem repeated sequences of amino acids. Here it is shown that the dominant epitope of Plasmodium falciparum is contained in the synthetic dodecapeptide Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro-Asn-Ala-Pro or (NANP)3. Monoclonal antibodies and most or all polyclonal human antibodies to the sporozoites react with (NANP)3, and polyclonal antibodies raised against the synthetic peptide (NANP)3 react with the surface of the parasite and neutralize its infectivity. Since (NANP)3 repeats are present in CS proteins of P. falciparum from many parts of the world, this epitope is a logical target for vaccine development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zavala, F -- Tam, J P -- Hollingdale, M R -- Cochrane, A H -- Quakyi, I -- Nussenzweig, R S -- Nussenzweig, V -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1436-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409595" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Antibodies, Monoclonal ; Child ; Epitopes/*immunology ; Humans ; Malaria/*prevention & control ; Peptides/immunology ; Plasmodium falciparum/*immunology ; *Vaccines
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diaz, M O -- Le Beau, M M -- Rowley, J D -- Drabkin, H A -- Patterson, D -- CA 16910/CA/NCI NIH HHS/ -- CA 25568/CA/NCI NIH HHS/ -- HD 13432/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):767-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3860954" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; *Chromosomes, Human, 21-22 and Y ; *Chromosomes, Human, 6-12 and X ; Humans ; Leukemia, Myeloid, Acute/*genetics ; Nucleic Acid Hybridization ; *Oncogenes ; *Translocation, Genetic
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    A human Y-linked DNA polymorphism and its potential for estimating genetic and evolutionary distance (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-12-20
    Description: A human DNA sequence (p12f2), derived from a partial Y-chromosome genomic library and showing homology with the X and Y chromosomes and with an undetermined number of autosomes, detected two Y-specific restriction fragment length variants on male DNA that had been digested with Taq I and Eco RI. These variants may have been generated through a deletion-insertion mechanism and their pattern of holoandric transmission indicates that they represent a two-allele Y-linked polymorphism (RFLP). By means of DNA from patients with inborn deletions in chromosome Y, this polymorphic DNA site was mapped to the interval Yq11.1-Yq11.22. The frequency of the rarest allele was about 35 percent in Algerian and Sardinian human males, whereas it was only 4 percent among Northern Europeans. The p12f2 probe also detected Y-specific DNA fragments in the gorilla and chimpanzee. In view of the monosomy of the Y chromosome in mammalian species, Y-linked RFLP's may prove to be more useful than autosomal or X-linked markers in estimating genetic distances within and between species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Casanova, M -- Leroy, P -- Boucekkine, C -- Weissenbach, J -- Bishop, C -- Fellous, M -- Purrello, M -- Fiori, G -- Siniscalco, M -- HD 16782/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1403-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2999986" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; *Biological Evolution ; DNA Restriction Enzymes ; *Genetic Variation ; Humans ; *Polymorphism, Genetic ; Sequence Homology, Nucleic Acid ; *Y Chromosome
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    Identification of a transcriptional enhancer element upstream from the proto-oncogene fos (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-12-06
    Description: Sequences upstream from the proto-oncogene fos were shown to be essential for its transcription. Transient expression of the chloramphenicol acetyl-transferase (CAT) gene linked to upstream sequences of the fos gene including its promoter reveals that sequences located 64 to 404 base pairs 5' to the fos cap site contain a typical transcriptional enhancer. Moreover, these enhancer sequences, which are strikingly conserved between mouse and human fos genes, coincide with a deoxyribonuclease I-hypersensitive site in the chromatin. The expression of the fos-CAT fusion genes was stimulated only two to three times by the fos inducer 12-0-tetradecanoyl phorbol-13-acetate. The fos enhancer does not appear to be tissue-specific.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deschamps, J -- Meijlink, F -- Verma, I M -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1174-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3865371" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/genetics ; Animals ; Chloramphenicol O-Acetyltransferase ; Chromatin/metabolism ; DNA, Recombinant ; Deoxyribonuclease I/metabolism ; *Enhancer Elements, Genetic ; *Genes, Regulator ; Humans ; Mice ; *Proto-Oncogenes ; *Transcription, Genetic
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    Plasma homovanillic acid concentration and the severity of schizophrenic illness (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-03-29
    Description: Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, K L -- Davidson, M -- Mohs, R C -- Kendler, K S -- Davis, B M -- Johns, C A -- DeNigris, Y -- Horvath, T B -- MH37922/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 29;227(4694):1601-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975630" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Haloperidol/pharmacology ; Homovanillic Acid/*blood ; Humans ; Male ; Phenylacetates/*blood ; Schizophrenia/*blood
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    Murine retroviral vectors and human gene therapy (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, D N -- New York, N.Y. -- Science. 1985 May 10;228(4700):650, 653.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3857706" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Genetic Engineering/methods ; *Genetic Vectors ; Humans ; Mice ; Retroviridae/*genetics
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  • 138
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    Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-08-23
    Description: Mouse lymphoma cells were hybridized with two human acute T-cell leukemias with a t(11;14) (p13;q11) translocation and the segregated hybrids were examined for the presence of the DNA segments coding for the constant (C) and the variable (V) regions of the alpha chain (C alpha and V alpha) of the T-cell receptor. The C alpha segment was translocated to the involved chromosome 11 (11p+) while the V alpha segment remained on the involved chromosome 14 (14q-). The data indicate that the locus for the alpha chain of the T-cell receptor is split by the chromosomal breakpoint between the V alpha and the C alpha gene segments, and that the V alpha segments are proximal to the C alpha segment within chromosome band 14q11.2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erikson, J -- Williams, D L -- Finan, J -- Nowell, P C -- Croce, C M -- CA16685/CA/NCI NIH HHS/ -- CA36521/CA/NCI NIH HHS/ -- CA39860/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):784-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3875152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Chromosomes, Human, 13-15 ; *Chromosomes, Human, 6-12 and X ; Gene Expression Regulation ; Genes ; Humans ; Leukemia/*genetics ; Oncogenes ; Receptors, Antigen, T-Cell/*genetics ; T-Lymphocytes/physiology ; *Translocation, Genetic
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    Selective sparing of a class of striatal neurons in Huntington's disease (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-11-01
    Description: A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in Huntington's disease. Biochemical assays confirmed a significant increase in the activity of this enzyme in both the caudate nucleus and putamen in postmortem brain tissue from patients with this disease. The resistance of these neurons suggests that the gene defect in Huntington's disease may be modifiable by the local biochemical environment. This finding may provide insight into the nature of the genetically programmed cell death that is a characteristic of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferrante, R J -- Kowall, N W -- Beal, M F -- Richardson, E P Jr -- Bird, E D -- Martin, J B -- IR 23NS 19867-1/NS/NINDS NIH HHS/ -- MN1NS-3187/NS/NINDS NIH HHS/ -- NS 16367/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):561-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2931802" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Caudate Nucleus/enzymology/pathology ; Corpus Striatum/enzymology/*pathology ; Humans ; Huntington Disease/enzymology/*pathology ; Middle Aged ; NADPH Dehydrogenase/analysis ; Nerve Tissue Proteins/analysis ; Neurons/enzymology/*pathology ; Neuropeptide Y
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  • 140
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    Picosecond time-resolved resonance Raman studies of hemoglobin: implications for reactivity (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-08-16
    Description: Picosecond time-resolved Raman spectra of hemoglobin generated with blue pulses (20 to 30 picoseconds) that were resonant with the Soret band and of sufficient intensity to completely photodissociate the starting liganded sample are reported. For both R- and T-state liganded hemoglobins, the peak frequencies in the spectrum of the deoxy transient were the same at approximately 25 picoseconds as those observed at 10 nanoseconds subsequent to photodissociation. In particular, the large R-T differences in the frequency of the stretching mode for the iron-proximal histidine bond (VFe-His) detected in previously reported nanosecond-resolved spectra were also evident in the picosecond-resolved spectra. The implications of this finding with respect to the distribution of strain energy in the liganded protein and the origin of the time course for geminate recombination are discussed. On the basis of these results, a microscopic model is proposed in which delocalization of strain energy is strongly coupled to the coordinate of the iron. The model is used to explain the origin of the R-T differences in the rates of ligand dissociation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Findsen, E W -- Friedman, J M -- Ondrias, M R -- Simon, S R -- 2-506 RR-8139/RR/NCRR NIH HHS/ -- R01 GM3333O-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):661-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023704" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; *Hemoglobin A ; Humans ; Motion ; Protein Conformation ; Spectrum Analysis, Raman ; Structure-Activity Relationship ; Thermodynamics
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    Alzheimer's disease: a biologist's perspectives (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-12-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finch, C E -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071039" target="_blank"〉PubMed〈/a〉
    Keywords: *Alzheimer Disease/genetics/pathology ; Animals ; Humans ; Rats
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    Emotions and facial expression (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fridlund, A J -- Gilbert, A N -- Izard, C E -- Burdett, A N -- New York, N.Y. -- Science. 1985 Nov 8;230(4726):607-8, 610, 687.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048950" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/blood supply ; Emotions/*physiology ; *Facial Expression ; Humans
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    Plasticity of hippocampal circuitry in Alzheimer's disease (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-12-06
    Description: Two markers of neuronal plasticity were used to compare the response of the human central nervous system to neuronal loss resulting from Alzheimer's disease with the response of rats to a similar neuronal loss induced by lesions. In rats that had received lesions of the entorhinal cortex, axon sprouting of commissural and associational fibers into the denervated molecular layer of the dentate gyrus was paralleled by a spread in the distribution of tritiated kainic acid-binding sites. A similar expansion of kainic acid receptor distribution was observed in hippocampal samples obtained postmortem from patients with Alzheimer's disease. An enhancement of acetylcholinesterase activity in the dentate gyrus molecular layer, indicative of septal afferent sprouting, was also observed in those patients with a minimal loss of cholinergic neurons. These results are evidence that the central nervous system is capable of a plastic response in Alzheimer's disease. Adaptive growth responses occur along with the degenerative events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geddes, J W -- Monaghan, D T -- Cotman, C W -- Lott, I T -- Kim, R C -- Chui, H C -- AG00538/AG/NIA NIH HHS/ -- MH 19691/MH/NIMH NIH HHS/ -- P50AG5142/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1179-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071042" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholinesterase/metabolism ; Alzheimer Disease/*pathology ; Animals ; Hippocampus/enzymology/*pathology ; Humans ; Kainic Acid/metabolism ; Male ; *Neuronal Plasticity ; Neurons/pathology ; Rats ; Rats, Inbred Strains
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    Transcription of class III genes activated by viral immediate early proteins (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-10-25
    Description: The adenovirus EIA and pseudorabies virus immediate early (IE) proteins induce transcription from transfected viral and nonviral genes transcribed by RNA polymerase II (class II genes). These proteins have now been shown also to activate transcription of transfected genes transcribed by RNA polymerase III (class III genes). As previously observed for class II genes, this stimulation of class III gene transcription was much greater for transfected genes than for the major endogenous cellular class III genes. Extracts made from cell lines stably expressing a transfected pseudorabies virus IE gene were 10 to 20 times more active in the in vitro transcription of exogenously added class III genes than extracts of the parental cell line. These results indicate that the E1A and IE proteins stimulate the expression of class III genes by a mechanism similar to the mechanism for stimulation of class II gene transcription by these proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaynor, R B -- Feldman, L T -- Berk, A J -- CA 25235/CA/NCI NIH HHS/ -- CA 30981/CA/NCI NIH HHS/ -- CA 32737/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Oct 25;230(4724):447-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996135" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviridae/genetics ; Animals ; Drosophila/genetics ; *Genes, Viral ; HeLa Cells ; Herpesvirus 1, Suid/genetics ; Humans ; RNA, Transfer/genetics ; Rabbits ; Rats ; *Transcription, Genetic ; Viral Proteins/*genetics
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    Colon cancer screening (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-11-01
    Description: Figure 10 on page 351 of the Research Article "Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA" by J. G. Izant and H. Weintraub (26 July, p. 345) was reproduced erroneously, so that the green stain (NBD-phallacidin) of the actin filaments was not chromatically resolved. The micrographs are intended to document the specific disruption of the actin microfilament distribution, while the RNA and DNA staining pattern (orange-red) was unaffected. The correct figure and legend appear below.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Franco, V W -- New York, N.Y. -- Science. 1985 Nov 1;230(4725):496.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048943" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Enzyme Tests ; Colon/enzymology ; Colonic Neoplasms/*diagnosis/genetics ; Humans ; Ornithine Decarboxylase/analysis ; Risk
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    Huntington's disease: two families with differing clinical features show linkage to the G8 probe (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-08-23
    Description: To test the hypothesis that interfamily variability in Huntington's Disease (HD) is due to mutation at different loci, linkage analysis was undertaken in two large HD kindreds that differed in ethnicity, age-at-onset, and neurologic and psychiatric features. Both families showed linkage of the HD locus to the G8 probe. Several recombinants were documented in each family, and the best estimate of the recombination fraction for the two families was 6 percent with a 95 percent confidence interval of 0 to 12 percent. Although the data support the existence of a single HD locus, use of the G8 probe for presymptomatic testing in these kindreds would have resulted in a 12 percent error rate in genotype assignment at the HD locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Folstein, S E -- Phillips, J A 3rd -- Meyers, D A -- Chase, G A -- Abbott, M H -- Franz, M L -- Waber, P G -- Kazazian, H H Jr -- Conneally, P M -- Hobbs, W -- AM 13983/AM/NIADDK NIH HHS/ -- NS 16367/NS/NINDS NIH HHS/ -- NS 16375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):776-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992086" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosomes, Human, 4-5 ; DNA Restriction Enzymes ; DNA, Recombinant ; Female ; Genetic Linkage ; Humans ; Huntington Disease/*genetics ; Male ; Pedigree ; Recombination, Genetic ; Risk
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    Rate theories and puzzles of hemeprotein kinetics (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-07-26
    Description: The binding of dioxygen and carbon monoxide to heme proteins such as myoglobin and hemoglobin has been studied with flash photolysis. At temperatures below 200 K, binding occurs from within the heme pocket and, contrary to expectation, with nearly equal rates for both ligands. This observation has led to a reexamination of the theory of the association reaction taking into account friction, protein structure, and the nature of electronic transitions. The rate coefficients for the limiting cases of large and small friction are found with simple arguments that use characteristic lengths and times. The arguments indicate how transition state theory as well as calculations based on nonadiabatic perturbation theory, which is called the Golden Rule, may fail. For ligand-binding reactions the data suggest the existence of intermediate states not directly observed so far. The general considerations may also apply to other biomolecular processes such as electron transport.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frauenfelder, H -- Wolynes, P G -- GM 18051/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):337-45.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012322" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Monoxide/metabolism ; Hemeproteins/*metabolism ; Hemoglobins/metabolism ; Humans ; Kinetics ; Mathematics ; Myoglobin/metabolism ; Oxygen/metabolism ; Spectrophotometry, Infrared ; Spectrum Analysis, Raman ; Thermodynamics
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  • 148
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    Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-03-22
    Description: Brain sections from patients who had died with senile dementia of the Alzheimer's type (SDAT), Huntington's disease (HD), or no neurologic disease were studied by autoradiography to measure sodium-independent L-[3H]glutamate binding. In brain sections from SDAT patients, glutamate binding was normal in the caudate, putamen, and claustrum but was lower than normal in the cortex. The decreased cortical binding represented a reduction in numbers of binding sites, not a change in binding affinity, and appeared to be the result of a specific decrease in numbers of the low-affinity quisqualate binding site. No significant changes in cortical binding of other ligands were observed. In brains from Huntington's disease patients, glutamate binding was lower in the caudate and putamen than in the same regions of brains from control and SDAT patients but was normal in the cortex. It is possible that development of positron-emitting probes for glutamate receptors may permit diagnosis of SDAT in vivo by means of positron emission tomographic scanning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenamyre, J T -- Penney, J B -- Young, A B -- D'Amato, C J -- Hicks, S P -- Shoulson, I -- NS00420/NS/NINDS NIH HHS/ -- NS00464/NS/NINDS NIH HHS/ -- NS17978/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Mar 22;227(4693):1496-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2858129" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/enzymology/*metabolism ; Autoradiography ; Binding Sites ; Brain/enzymology/*metabolism ; Caudate Nucleus/metabolism ; Cerebral Cortex/metabolism ; Choline O-Acetyltransferase/metabolism ; Glutamates/*metabolism ; Glutamic Acid ; Humans ; Huntington Disease/enzymology/*metabolism ; Putamen/metabolism ; Receptors, Glutamate ; Receptors, Neurotransmitter/*metabolism
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    Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-21
    Description: Human factor VIII--von Willebrand factor (vWF) is a large, multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a carrier for factor VIIIC (antihemophilic factor) and as a major mediator of platelet-vessel wall interaction. Diminished or abnormal vWF activity results in von Willebrand's disease (vWD), a common and complex hereditary bleeding disorder. Overlapping vWF cDNA clones that span 8.2 kilobases of the vWF messenger RNA have been obtained. vWF accounts for approximately 0.3 percent of endothelial cell messenger RNA and was undetectable in several other tissues examined. A large single copy gene for vWF is located on the short arm of chromosome 12 (12p12----12pter). No gross gene rearrangement or deletion was detected in the DNA of two patients with severe vWD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ginsburg, D -- Handin, R I -- Bonthron, D T -- Donlon, T A -- Bruns, G A -- Latt, S A -- Orkin, S H -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1401-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3874428" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Blood Coagulation Factors/*genetics ; Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; Cloning, Molecular ; DNA/*isolation & purification ; Humans ; RNA, Messenger ; von Willebrand Factor/*genetics
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    Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-08
    Description: Human T-cell leukemia virus type I (HTLV-I) is a retrovirus associated with adult T-cell leukemia and lymphoma. In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3' end of the envelope gene and the 3' long terminal repeat sequence (LTR). It has been suggested that a protein of 42 kilodaltons that is encoded by the LOR region may participate in both trans-acting transcriptional regulation of the viral LTR as well as in the transforming properties of HTLV-I. It is reported here that a significant fraction of the 42-kilodalton HTLV LOR product is located in the nucleus of HTLV-I-infected transformed lymphocytes, a finding that is consistent with its proposed functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goh, W C -- Sodroski, J -- Rosen, C -- Essex, M -- Haseltine, W A -- CA07094/CA/NCI NIH HHS/ -- CA07580/CA/NCI NIH HHS/ -- CA09361/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Mar 8;227(4691):1227-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2983419" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Fractionation ; Cell Nucleus/metabolism ; Cytosol/metabolism ; Deltaretrovirus/*genetics ; Humans ; Lymphocytes/metabolism ; Neoplasm Proteins/genetics/*isolation & purification ; Oncogenes ; Subcellular Fractions/metabolism
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  • 151
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    Peroxisomal defects in neonatal-onset and X-linked adrenoleukodystrophies (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-04
    Description: Accumulation of very long chain fatty acids in X-linked and neonatal forms of adrenoleukodystrophy (ALD) appears to be a consequence of deficient peroxisomal oxidation of very long chain fatty acids. Peroxisomes were readily identified in liver biopsies taken from a patient having the X-linked disorder. However, in liver biopsies from a patient having neonatal-onset ALD, hepatocellular peroxisomes were greatly reduced in size and number, and sedimentable catalase was markedly diminished. The presence of increased concentrations of serum pipecolic acid and the bile acid intermediate, trihydroxycoprostanic acid, in the neonatal ALD patient are associated with a generalized diminution of peroxisomal activities that was not observed in the patient with X-linked ALD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldfischer, S -- Collins, J -- Rapin, I -- Coltoff-Schiller, B -- Chang, C H -- Nigro, M -- Black, V H -- Javitt, N B -- Moser, H W -- Lazarow, P B -- AG-01468/AG/NIA NIH HHS/ -- AM-17702/AM/NIADDK NIH HHS/ -- N5-03356/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):67-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3964959" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenoleukodystrophy/genetics/metabolism/*pathology ; Adult ; Animals ; Bile Acids and Salts/metabolism ; Catalase/metabolism ; Child ; Child, Preschool ; Diffuse Cerebral Sclerosis of Schilder/*pathology ; Female ; Humans ; Liver/pathology ; Male ; Microbodies/*pathology ; Oxidation-Reduction ; Pipecolic Acids/blood ; Rats ; *X Chromosome
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    Court rules in patient privacy case (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1985 Jul 26;229(4711):360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3892691" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality/*legislation & jurisprudence ; Humans ; Massachusetts ; Medicaid/legislation & jurisprudence ; Professional Misconduct ; Psychiatry ; Judicial Court ruled that a psychiatrist being investigated for possible Medicaid ; fraud did not have to turn over all of his notes concerning therapy sessions. The ; Court said that portions of the records reflecting feelings and impressions or ; the substance of the diagnosis could be withheld ; however, information regarding ; drugs prescribed, electroshock therapy, or notes on the patient's condition and ; progress should be disclosed. Since increased access to medical records by ; insurers, investigators, hospital staff, and others has already eroded the right ; to privacy, the issues raised by this case are disturbing to psychiatrists who ; fear that wholesale disclosure of records may be mandated. They believe that such ; disclosure would adversely affect the doctor patient relationship and the ; psychotherapeutic process.
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  • 153
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    ADAMHA funding pressed (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Jan 11;227(4683):147-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966149" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Mental Disorders ; National Institute of Mental Health (U.S.) ; *Research Support as Topic ; *Substance-Related Disorders ; United States
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  • 154
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    A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-08
    Description: A gene bank of DNA from the Lyme disease spirochete was constructed in the plasmid pBR322. Plasmid pTRH32, a recombinant that in Escherichia coli expresses the two major outer surface proteins of the Lyme disease spirochete, was identified. One of the recombinant products, designated OspA, represents a surface protein that appears to be common to all Lyme disease spirochetes, whereas the other recombinant product, designated OspB, represents a more variable surface protein. This recombinant plasmid provides a foundation for future studies on the epidemiology and pathogenesis of Lyme disease as well as on the genetic organization of the etiologic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, T R -- Mayer, L W -- Barbour, A G -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):645-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969554" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/*genetics ; Borrelia/*metabolism ; *Borrelia burgdorferi ; DNA, Recombinant/*metabolism ; Electrophoresis, Polyacrylamide Gel ; Humans ; Lyme Disease/*microbiology ; *Plasmids ; Proteins/genetics
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  • 155
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    Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-20
    Description: The products of the adenovirus-2 (Ad2) immortalizing oncogene E1A repress the activity of the SV40, polyoma virus and E1A enhancers. Evidence is presented that Ad2 infection of MPC11 plasmocytoma cells results in an inhibition of transcription of both the gamma 2b heavy chain (IgH) and the kappa light chain immunoglobulin genes. This inhibition is caused by the Ad2 E1A products. Furthermore, the Ad2 E1A products repress transcription activated by the immunoglobulin heavy chain enhancer in chimeric recombinants, which are either stably integrated in the genome of lymphoid cells or are present as episomes. The implications of negative regulation of cellular enhancers are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hen, R -- Borrelli, E -- Chambon, P -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1391-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2999984" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/*genetics ; *Cell Transformation, Viral ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; Endonucleases ; *Enhancer Elements, Genetic ; Genes ; *Genes, Regulator ; *Genes, Viral ; Humans ; Immunoglobulin Heavy Chains/*genetics ; *Oncogenes ; Plasmids ; Single-Strand Specific DNA and RNA Endonucleases ; Transcription, Genetic
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  • 156
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    cis- and trans-acting transcriptional regulation of visna virus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-02
    Description: Visna virus is a pathogenic lentivirus of sheep that is related to human T-cell lymphotropic virus type III (HTLV-III), the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). The transcriptional activity of visna virus promoter and enhancer sequences was studied by means of an assay based on the transient expression of the bacterial gene chloramphenicol acetyltransferase (CAT). The results suggest that the high level of expression of visna virus is due in part to cis-acting enhancer sequences that give the viral promoter a high level of transcriptional activity. In addition, the rate of transcription from the visna virus promoter situated in a plasmid expressing the CAT gene was much greater in infected than uninfected cells. This phenomenon of trans-acting transcriptional activation may involve either virally or cellularly encoded factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hess, J L -- Clements, J E -- Narayan, O -- NS-15721/NS/NINDS NIH HHS/ -- NS-16145/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 2;229(4712):482-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2990051" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/genetics ; Animals ; Base Sequence ; Cell Line ; Chloramphenicol O-Acetyltransferase ; Choroid Plexus ; Chromosome Mapping ; Enhancer Elements, Genetic ; *Genes, Regulator ; Goats ; Humans ; L Cells (Cell Line) ; Macrophages ; Mice ; Plasmids ; Promoter Regions, Genetic ; Sheep ; Synovial Membrane ; T-Lymphocytes ; *Transcription, Genetic ; Transfection ; Visna-maedi virus/*genetics
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  • 157
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    Violence seen as public health issue (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1257.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4071047" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Public Health ; United States ; Violence/*physiopathology
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  • 158
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    IOM presents more nuclear war data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, Constance -- New York, N.Y. -- Science. 1985 Oct 11;230(4722):156.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11643807" target="_blank"〉PubMed〈/a〉
    Keywords: Hazardous Substances ; Humans ; Institute of Medicine (U.S.) ; Morbidity ; Mortality ; *Nuclear Warfare ; Public Policy ; *Social Change ; United States
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  • 159
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    The neglected disease in medical education (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):741-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023709" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*education ; Education, Medical ; Humans
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  • 160
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    The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-13
    Description: Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a 22,000-dalton glycoprotein that stimulates the growth of myeloid progenitor cells and acts directly on mature neutrophils. A full-length complementary DNA clone encoding human GM-CSF was used as a probe to screen a human genomic library and isolate the gene encoding human GM-CSF. The human GM-CSF gene is approximately 2.5 kilobase pairs in length with at least three intervening sequences. The GM-CSF gene was localized by somatic cell hybrid analysis and in situ hybridization to human chromosome region 5q21-5q32, which is involved in interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. An established, human promyelocytic leukemia cell line, HL60, contains a rearranged, partially deleted GM-CSF allele and a candidate 5q- marker chromosome, indicating that the truncated GM-CSF allele may reside at the rejoining point for the interstitial deletion on the HL60 marker chromosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huebner, K -- Isobe, M -- Croce, C M -- Golde, D W -- Kaufman, S E -- Gasson, J C -- CA-10805/CA/NCI NIH HHS/ -- CA-16685/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Dec 13;230(4731):1282-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2999978" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia/genetics ; Base Sequence ; Cell Line ; Chromosome Aberrations/*genetics ; Chromosome Deletion ; Chromosome Disorders ; Chromosome Mapping ; *Chromosomes, Human, 4-5 ; Colony-Stimulating Factors/*genetics ; DNA Restriction Enzymes ; Genes ; Granulocytes ; Humans ; Leukemia, Myeloid, Acute/genetics ; Macrophages ; Syndrome
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  • 161
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    Persistent noncytopathic infection of normal human T lymphocytes with AIDS-associated retrovirus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-27
    Description: Infection of normal peripheral blood T cells by the acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) was evaluated in long-term cultures of helper-inducer T cells (T4 cells). Cells that were inoculated with ARV and maintained in medium supplemented with interleukin-2 remained productively infected with this virus for more than 4 months in culture, although they showed no cytopathic effects characteristic of acute ARV infection. The presence of replicating virus was demonstrated by reverse transcriptase activity of culture fluids and by viral antigens and budding particles detected on cells by immunofluorescence and electron microscopy. Virus produced in these cultures remained infectious and could induce cytopathic effects and viral antigens in uninfected lymphoid cells. The finding that normal lymphocytes may be productively infected by an AIDS retrovirus in the absence of cell death suggests that a range of biologic effects may occur after infection in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoxie, J A -- Haggarty, B S -- Rackowski, J L -- Pillsbury, N -- Levy, J A -- CA-34980/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Sep 27;229(4720):1400-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994222" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/immunology/*microbiology ; Antigens, Viral/immunology ; Cells, Cultured ; Deltaretrovirus/immunology ; Humans ; Microscopy, Fluorescence ; Retroviridae Infections/immunology/microbiology ; T-Lymphocytes/*microbiology
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  • 162
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    The goldfish as a retinex animal (1985)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1985-02-08
    Description: In an experiment designed to test color constancy in a situation comparable to that used in E. H. Land's experiments with human observers, goldfish were trained to approach a particular color within a richly colored but variable "Mondrian" background. They retained the ability to identify colors accurately even when the spectral composition of the illuminant was radically altered in generalization tests. Since the behavior of fish resembles that of human beings in these tests, Land's retinex theory seems to apply to a relatively primitive vertebrate as well as to humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingle, D J -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):651-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969555" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/physiology ; Color ; Color Perception/*physiology ; Cyprinidae/*physiology ; Goldfish/*physiology ; Humans ; Lighting ; Macaca mulatta ; Retina/*physiology ; Visual Perception/physiology
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  • 163
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    Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-03
    Description: The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isobe, M -- Erikson, J -- Emanuel, B S -- Nowell, P C -- Croce, C M -- CA15822/CA/NCI NIH HHS/ -- CA16685/CA/NCI NIH HHS/ -- GM20700/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 May 3;228(4699):580-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3983641" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Ataxia Telangiectasia/genetics ; Chromosome Aberrations/genetics ; Chromosome Disorders ; *Chromosome Mapping ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 6-12 and X ; Female ; Humans ; Male ; Mice ; Receptors, Antigen, T-Cell/*genetics
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  • 164
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    Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-19
    Description: Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jahnke, U -- Fischer, E H -- Alvord, E C Jr -- AM07902/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1985 Jul 19;229(4710):282-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2409602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chickens ; Encephalomyelitis/etiology/immunology/*metabolism ; Epitopes ; Guinea Pigs ; Haplorhini ; Humans ; Measles/metabolism ; Myelin Basic Protein/genetics ; Myelin P2 Protein ; Neuritis/etiology/immunology/*metabolism ; Rabbits ; Rats ; Rats, Inbred Lew ; Viral Proteins/*genetics ; Viral Vaccines/adverse effects/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 165
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    Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-20
    Description: Regulation of transcription of members of the ras gene family undoubtably plays an important role in controlling cellular growth. Examination of this level of regulation requires identification of the promoter regions of the ras proto-oncogenes. Four major transcriptional start sites were detected in the human Harvey ras 1 proto-oncogene. The promoter region contains neither a TATA box nor a CAAT box in their characteristic upstream positions, has an extremely high G+C content (80 percent), and contains multiple GC boxes including seven CCGCCC repeats and three repeats of the inverted complement, GGGCGG. This region has strong promoter activity when placed upstream from the chloramphenicol acetyl transferase gene and transfected into monkey CV1 cells. In these ways the Harvey ras 1 proto-oncogene promoter resembles the promoter of the gene encoding the epidermal growth factor (EGF) receptor. The similarity between the two proto-oncogene promoters may be relevant to the mechanism by which the expression of such "growth control" genes is regulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishii, S -- Merlino, G T -- Pastan, I -- New York, N.Y. -- Science. 1985 Dec 20;230(4732):1378-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2999983" target="_blank"〉PubMed〈/a〉
    Keywords: DNA Restriction Enzymes ; Epidermal Growth Factor/metabolism ; *Genes ; Humans ; Nucleic Acid Hybridization ; Plasmids ; *Promoter Regions, Genetic ; *Proto-Oncogenes ; RNA, Messenger/genetics ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics ; Sequence Homology, Nucleic Acid ; Transcription, Genetic
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    The generative grammar of the immune system (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jerne, N K -- New York, N.Y. -- Science. 1985 Sep 13;229(4718):1057-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4035345" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies/analysis ; Humans ; *Immune System ; Lymphocytes/physiology ; Mice
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  • 167
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    Human T-cell receptor alpha-chain genes: location on chromosome 14 (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-04-05
    Description: The genes encoding the alpha chain of the human T-cell receptor have been mapped to chromosome 14, the chromosome on which the human immunoglobulin heavy chain locus resides. Thus, genes encoding two different classes of antigen receptor are present on the same chromosome. Furthermore, breaks involving chromosome 14 are frequently seen in tumors of T-cell origin. The potential relation of these chromosome abnormalities to alpha-chain genes is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, C -- Morse, H G -- Kao, F T -- Carbone, A -- Palmer, E -- CA-18734/CA/NCI NIH HHS/ -- HD-02080/HD/NICHD NIH HHS/ -- HD-17717/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):83-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3919444" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations ; Chromosome Disorders ; *Chromosome Mapping ; *Chromosomes, Human, 13-15 ; Cricetinae ; Cricetulus ; DNA/genetics ; Humans ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin alpha-Chains/*genetics ; Leukemia/genetics ; Lymphoma/genetics ; Nucleic Acid Hybridization ; Receptors, Antigen, T-Cell/*genetics
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  • 168
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    Partial primary structure of the alpha and beta chains of human tumor T-cell receptors (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-18
    Description: The T-cell receptor for antigen (Ti) was purified from the human tumor cell line HPB-ALL. Amino-terminal sequence analysis of an acid-cleaved peptide of the Ti alpha chain showed that it is highly homologous to a putative murine alpha chain recently described. Amino-terminal sequence analysis of the Ti beta chain revealed that it shares 50 percent homology with the Ti beta chain amino acid sequences from two other human T-cell tumors. Nucleotide sequence analysis of a complementary DNA clone encoding the Ti beta chain from the HPB-MLT cell line showed that this chain represents a second human constant region gene segment and suggested that it arises from direct joining of the variable and joining gene segments without any intervening D region sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, N -- Leiden, J -- Dialynas, D -- Fraser, J -- Clabby, M -- Kishimoto, T -- Strominger, J L -- Andrews, D -- Lane, W -- Woody, J -- 5 R01 AI15669/AI/NIAID NIH HHS/ -- AI10736/AI/NIAID NIH HHS/ -- Y001CP00502/CP/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jan 18;227(4684):311-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3871253" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Humans ; Immunoglobulin Constant Regions/genetics ; Leukemia, Lymphoid/immunology ; Lymphoma/immunology ; Mice ; Nucleic Acid Hybridization ; Receptors, Antigen, T-Cell/*genetics ; T-Lymphocytes/*immunology
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  • 169
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    Modulation of the sis gene transcript during endothelial cell differentiation in vitro (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: Endothelial cells, which line the interior walls of blood vessels, proliferate at the site of blood vessel injury. Knowledge of the factors that control the proliferation of these cells would help elucidate the role of endothelial cells in wound healing, tumor growth, and arteriosclerosis. In vitro, endothelial cells organize into viable, three-dimensional tubular structures in environments that limit cell proliferation. The process of endothelial cell organization was found to result in decreased levels of the sis messenger RNA transcript and increased levels of the messenger RNA transcript for fibronectin. This situation was reversed on transition from the organized structure to a proliferative monolayer. These results suggest a reciprocity for two biological response modifiers involved in the regulation of endothelial cell proliferation and differentiation in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaye, M -- McConathy, E -- Drohan, W -- Tong, B -- Deuel, T -- Maciag, T -- 14147/PHS HHS/ -- 310765/PHS HHS/ -- 4807/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1985 May 17;228(4701):882-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3890179" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Division ; Cells, Cultured ; Culture Media ; Endothelial Growth Factors ; Endothelium/*cytology/metabolism ; Extracellular Matrix/metabolism ; Fibronectins/biosynthesis/genetics ; *Gene Expression Regulation ; Growth Substances/pharmacology ; Humans ; Platelet-Derived Growth Factor/*genetics ; RNA, Messenger/*genetics ; *Transcription, Genetic
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  • 170
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    Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-04-05
    Description: Induction of cytochrome P1-450 has been linked to susceptibility to certain chemically induced cancers in mouse and man. Treatment of the human cell line MCF-7 with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) results in high levels of aryl hydrocarbon (benzo[a]pyrene) hydroxylase (P1-450) activity. This cell line was used to isolate a human P1-450 full-length complementary DNA (cDNA) clone. The cDNA is 2566 nucleotides in length, encodes a polyadenylated messenger RNA (2.8 kilobases in length), and has a continuous reading frame producing a protein with 512 residues (molecular weight, 58,151). The human P1-450 cDNA and protein are 63 percent and 80 percent similar to mouse P1-450 cDNA and protein, respectively. Whereas the mouse TCDD-inducible P-450 gene subfamily has two members (P1-450 and P3-450), the human TCDD-inducible gene subfamily appears to have only one gene (P1-450).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaiswal, A K -- Gonzalez, F J -- Nebert, D W -- New York, N.Y. -- Science. 1985 Apr 5;228(4695):80-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3838385" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Carcinogens/pharmacology ; Cell Line ; Cricetinae ; Cytochrome P-450 Enzyme System/*genetics ; DNA/*genetics ; Dioxins/*pharmacology ; Enzyme Induction ; Humans ; Mice ; Nucleic Acid Hybridization ; Rabbits ; Tetrachlorodibenzodioxin/*pharmacology
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    Criminality and adoption (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kamin, L J -- Moses, L E -- Mednick, S A -- Gabrielli, W F Jr -- Hutchings, B -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):983-4,986,989.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975605" target="_blank"〉PubMed〈/a〉
    Keywords: *Adoption ; Antisocial Personality Disorder/genetics ; *Crime ; Family ; Female ; Humans ; Male ; Statistics as Topic
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  • 172
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    AIDS repository (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-07-05
    Description: In the article "Spotlight falls on science policy" (News and Comment, 10 May, p. 691) by Mark H. Crawford, the findings of a General Accounting Office report on the operating costs of the Continuous Electron Beam Accelerator Facility (CEBAF) were overstated. The report found that the Department of Energy's operating costs would rise by $80 million if both CEBAF and the Relativistic Heavy Ion Collider are constructed. CEBAF's operating cost is estimated to be $30 million. The report also found problems in accommodating the operating costs of the proposed Superconducting Super Collider in the department's budget.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaslow, R A -- New York, N.Y. -- Science. 1985 Jul 5;229(4708):8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012314" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; *Homosexuality ; Humans ; Male ; National Institutes of Health (U.S.) ; United States
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  • 173
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    Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-10
    Description: The natural history of estrogen-responsive breast cancers often involves a phenotypic change to an estrogen-unresponsive, more aggressive tumor. The human breast cancer cell line, MCF-7, which requires estradiol for tumor formation in vivo and shows growth stimulation in response to estradiol in vitro, is a model for hormone-responsive tumors. The v-rasH onc gene was transfected into MCF-7 cells. The cloned MCF-7ras transfectants, which expressed the v-rasH messenger RNA and v-rasH p21 protein (21,000 daltons), were characterized. In contrast to the parental cell line, MCF-7ras cells no longer responded to exogenous estrogen in culture and their growth was minimally inhibited by exogenous antiestrogens. When tested in the nude mouse, the MCF-7ras cells were fully tumorigenic in the absence of estrogen supplementation. Thus, cells acquiring an activated onc gene can bypass the hormonal regulatory signals that trigger the neoplastic growth of a human breast cancer cell line.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kasid, A -- Lippman, M E -- Papageorge, A G -- Lowy, D R -- Gelmann, E P -- New York, N.Y. -- Science. 1985 May 10;228(4700):725-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4039465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/chemically induced/*genetics ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; DNA, Neoplasm/genetics ; Estrogens/*pharmacology ; Female ; Humans ; Mice ; Mice, Nude ; Neoplasms, Experimental/chemically induced/genetics ; *Oncogenes ; Pyrrolidines/pharmacology ; Repetitive Sequences, Nucleic Acid ; Thiophenes/pharmacology ; *Transfection
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  • 174
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    Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1) (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: Complementary DNA (cDNA) clones encoding human macrophage-specific specific colony-stimulating factor (CSF-1) were isolated. One cDNA clone codes for a mature polypeptide of 224 amino acids and a putative leader of 32 amino acids. This cDNA, which was cloned in the Okayama-Berg expression vector, specifies the synthesis of biologically active CSF-1 in COS cells, as determined by a specific radioreceptor assay, macrophage bone marrow colony formation, and antibody neutralization. Most of the cDNA isolates contain part of an intron sequence that changes the reading frame, resulting in an abrupt termination of translation; these cDNA's were inactive in COS cells. The CSF-1 appears to be encoded by a single-copy gene, but its expression results in the synthesis of several messenger RNA species, ranging in size from about 1.5 to 4.5 kilobases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kawasaki, E S -- Ladner, M B -- Wang, A M -- Van Arsdell, J -- Warren, M K -- Coyne, M Y -- Schweickart, V L -- Lee, M T -- Wilson, K J -- Boosman, A -- C32551/PHS HHS/ -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):291-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996129" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Cell Line ; *Cloning, Molecular ; Colony-Stimulating Factors/*genetics ; DNA/*metabolism ; DNA Restriction Enzymes ; *Genes ; Humans ; Macrophages/*metabolism ; Pancreatic Neoplasms ; RNA, Messenger/genetics ; Transcription, Genetic
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  • 175
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    Amplification of a novel v-erbB-related gene in a human mammary carcinoma (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-06
    Description: The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to v-erbB but amplified in a manner that appeared to distinguish it from the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, C R -- Kraus, M H -- Aaronson, S A -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):974-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992089" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Breast Neoplasms/*genetics ; Cell Line ; Cloning, Molecular ; DNA, Neoplasm/*genetics ; Female ; *Gene Amplification ; Gene Expression Regulation ; Humans ; *Oncogenes ; Protein Kinases/*genetics ; Protein-Tyrosine Kinases ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics
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  • 176
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    Qinghaosu (artemisinin): an antimalarial drug from China (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-31
    Description: The herb Artemisia annua has been used for many centuries in Chinese traditional medicine as a treatment for fever and malaria. In 1971, Chinese chemists isolated from the leafy portions of the plant the substance responsible for its reputed medicinal action. This compound, called qinghaosu (QHS, artemisinin), is a sesquiterpene lactone that bears a peroxide grouping and, unlike most other antimalarials, lacks a nitrogen-containing heterocyclic ring system. The compound has been used successfully in several thousand malaria patients in China, including those with both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Derivatives of QHS, such as dihydroqinghaosu, artemether, and the water-soluble sodium artesunate, appear to be more potent than QHS itself. Sodium artesunate acts rapidly in restoring to consciousness comatose patients with cerebral malaria. Thus QHS and its derivatives offer promise as a totally new class of antimalarials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klayman, D L -- New York, N.Y. -- Science. 1985 May 31;228(4703):1049-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3887571" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antimalarials ; *Artemisinins ; Brain Diseases/therapy ; Chemical Phenomena ; Chemistry ; Humans ; Liver/metabolism ; Malaria/*drug therapy ; Medicine, Chinese Traditional ; Metabolic Clearance Rate ; Plants, Medicinal/analysis ; Plasmodium berghei ; Plasmodium falciparum ; *Sesquiterpenes/isolation & purification/metabolism/therapeutic use/toxicity
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    Down syndrome--Alzheimer's linked (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1152-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2933807" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Alzheimer Disease/*pathology ; Brain/pathology ; Down Syndrome/*pathology ; Female ; Humans ; Middle Aged
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  • 178
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    Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-04
    Description: Apolipoprotein (apo-) B is the ligand responsible for the receptor-mediated catabolism of low density lipoproteins, the principal cholesterol-transporting lipoproteins in plasma. The primary structure of the carboxyl-terminal 30 percent (1455 amino acids) of human apo-B (apo-B100) has been deduced from the nucleotide sequence of complementary DNA. Portions of the protein structure that may relate to its receptor binding function and lipid binding properties have been identified. The apo-B100 messenger RNA is about 19 kilobases in length. The apo-B100 gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B100 is located in the p24 region (near the tip of the short arm) of chromosome 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knott, T J -- Rall, S C Jr -- Innerarity, T L -- Jacobson, S F -- Urdea, M S -- Levy-Wilson, B -- Powell, L M -- Pease, R J -- Eddy, R -- Nakai, H -- GM 20454/GM/NIGMS NIH HHS/ -- HO 05196/HO/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1985 Oct 4;230(4721):37-43.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2994225" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Apolipoprotein B-100 ; Apolipoproteins B/analysis/*genetics ; Apolipoproteins E/analysis ; Base Sequence ; *Chromosome Mapping ; Chromosomes, Human, 1-3 ; DNA/analysis ; DNA Restriction Enzymes/metabolism ; Female ; *Gene Expression Regulation ; Haplorhini ; Humans ; Intestine, Small/metabolism ; Lipid Metabolism ; Lipoproteins, LDL/metabolism ; Liver/metabolism ; Mice ; RNA, Messenger/analysis ; Receptors, LDL/metabolism ; Structure-Activity Relationship
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  • 179
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    Dispute over access to Reye's study data (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):297-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2996130" target="_blank"〉PubMed〈/a〉
    Keywords: Aspirin/*adverse effects ; Centers for Disease Control and Prevention (U.S.) ; Child ; Federal Government ; Humans ; *Jurisprudence ; Research ; Reye Syndrome/*chemically induced ; *Technology, Pharmaceutical ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 180
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    What causes nearsightedness? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Sep 20;229(4719):1249-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3929381" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Environment/*adverse effects ; Haplorhini ; Humans ; Myopia/*etiology/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 181
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    Breast cancer consensus (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-09-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Sep 27;229(4720):1378.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3898364" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Breast Neoplasms/*drug therapy/pathology/therapy ; Clinical Trials as Topic ; Female ; Humans ; Lymphatic Metastasis ; Menopause ; Middle Aged ; National Institutes of Health (U.S.) ; Receptors, Estrogen/drug effects ; Tamoxifen/therapeutic use ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 182
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    Closing in on the muscular dystrophy gene (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Oct 18;230(4723):307-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4048935" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Deletion ; *Genes ; Humans ; Muscular Dystrophies/*genetics ; *Sex Chromosome Aberrations ; Transcription, Genetic ; *X Chromosome
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 183
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    Clotting protein cloned (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jun 21;228(4706):1415-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3874429" target="_blank"〉PubMed〈/a〉
    Keywords: Arteriosclerosis/genetics ; Blood Coagulation ; Blood Coagulation Factors/*genetics ; Cloning, Molecular ; *Genes ; Humans ; von Willebrand Diseases/genetics ; von Willebrand Factor/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 184
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    Fitting methylation into development (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1183-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001936" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Animals ; Cytosine/*analogs & derivatives/metabolism ; DNA/genetics ; *Gene Expression Regulation ; Humans ; *Methylation ; Nucleosomes/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 185
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    Jury clears Bendectin (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Mar 29;227(4694):1559.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975625" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/etiology ; Dicyclomine ; Doxylamine/*adverse effects ; Drug Combinations/adverse effects ; Female ; Humans ; Jurisprudence ; Pregnancy ; Pyridines/*adverse effects ; Pyridoxine/*adverse effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 186
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    Surgeons disagree on artificial heart (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Nov 15;230(4727):786-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3904000" target="_blank"〉PubMed〈/a〉
    Keywords: Heart Transplantation ; *Heart, Artificial ; Humans ; Patient Selection ; Resource Allocation ; *Risk Assessment ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 187
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    Debate over colon cancer screening (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Aug 16;229(4714):636-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023703" target="_blank"〉PubMed〈/a〉
    Keywords: Colonic Neoplasms/*diagnosis ; Humans ; Mass Screening ; Occult Blood
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 188
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    Is the war on cancer being won? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Aug 9;229(4713):543-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023699" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Neoplasms/diagnosis/mortality/*prevention & control ; Research ; Statistics as Topic ; Time Factors ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 189
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    A new approach to cystic fibrosis (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Apr 12;228(4696):167-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2579434" target="_blank"〉PubMed〈/a〉
    Keywords: Chlorides/metabolism ; Cystic Fibrosis/*genetics/pathology ; Humans ; Ion Channels/metabolism ; Lung/pathology ; Sweat Glands/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 190
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    Obesity declared a disease (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Mar 1;227(4690):1019-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975599" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Body Weight ; Child ; Female ; Humans ; Male ; Middle Aged ; *Obesity/complications
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 191
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    Why do people get fat? (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Mar 15;227(4692):1327-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975619" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/physiopathology ; Animals ; Diet ; Eating ; Female ; Humans ; Male ; Obesity/*etiology/physiopathology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 192
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    Study of Reye's-aspirin link raises concerns (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966155" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Aspirin/*adverse effects ; Chickenpox/drug therapy ; Child ; Humans ; Influenza, Human/drug therapy ; Pilot Projects ; Reye Syndrome/*chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 193
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    Induction of hepatitis B virus core gene in human cells by cytosine demethylation in the promoter (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-31
    Description: A recombinant human cell line constructed by transfection of epithelial cells with a plasmid containing the hepatitis B virus core gene (HBc) was used to study the regulation of HBc gene expression. Methylation of a single Hpa II site 280 base pairs upstream from the structural gene was found to regulate the expression of the core gene. Expression increased in cells treated with 5'-azacytidine as a result of cytosine demethylation at this site, and there was a fivefold increase in the number of HBc gene transcripts in total cellular messenger RNA. The varied life cycle of hepatitis B virus in disease such as viral hepatitis and liver cancer may therefore be attributable to the site-specific regulation of the gene involved in replication of the viral DNA and to the cytophathic effects elicited by this gene in human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korba, B E -- Wilson, V L -- Yoakum, G H -- New York, N.Y. -- Science. 1985 May 31;228(4703):1103-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2581318" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; Azacitidine/pharmacology ; Cytosine/*analogs & derivatives/metabolism ; DNA Restriction Enzymes ; DNA, Viral/genetics ; *Gene Expression Regulation/drug effects ; Genes, Viral ; Hepatitis B Core Antigens/*genetics ; Humans ; *Methylation ; *Promoter Regions, Genetic ; Time Factors ; Transcription, Genetic ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 194
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    Testing for trichinosis (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Feb 8;227(4687):621, 624.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969551" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Enzyme-Linked Immunosorbent Assay ; Humans ; *Meat ; Swine ; Trichinella ; Trichinellosis/*prevention & control ; United States
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  • 195
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    Heart panel's conclusions questioned (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jan 4;227(4682):40-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3880617" target="_blank"〉PubMed〈/a〉
    Keywords: Cholesterol/*blood ; Cholesterol, Dietary/adverse effects ; Clinical Trials as Topic ; Coronary Disease/etiology/*prevention & control ; Diet ; Female ; Humans ; Male ; Middle Aged ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 196
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    Avoiding the schistosome's tricks (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Jan 18;227(4684):285-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3966154" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/immunology ; Antigens/immunology ; Female ; Humans ; Male ; Schistosoma/growth & development/*immunology ; Schistosomiasis/immunology/parasitology ; Vaccines/immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 197
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    Virus-heart link studied (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1985 Feb 15;227(4688):735.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3969563" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriosclerosis/*microbiology ; Herpesviridae ; Humans
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 198
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    Benefits, risks, vaccines, and the courts (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1985 Mar 15;227(4692):1289.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3975614" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Compensation and Redress ; Federal Government ; Humans ; Jurisprudence ; Legislation, Medical ; Risk Assessment ; United States ; *Vaccines/adverse effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 199
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    Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-02-22
    Description: Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kranz, D M -- Saito, H -- Disteche, C M -- Swisshelm, K -- Pravtcheva, D -- Ruddle, F H -- Eisen, H N -- Tonegawa, S -- CA-24051/CA/NCI NIH HHS/ -- CA-28900-04/CA/NCI NIH HHS/ -- GM 30476-03/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Feb 22;227(4689):941-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3918347" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; Cricetinae ; Cricetulus ; Genes ; Humans ; Hybrid Cells/metabolism ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin alpha-Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Major Histocompatibility Complex ; Mice ; Receptors, Antigen, T-Cell/*genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 200
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    Myosin: a link between streptococci and heart (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-01-25
    Description: Murine monoclonal antibodies to Streptococcus pyogenes reacted with skeletal muscle myosin. High molecular weight proteins in extracts of human heart tissue that reacted with an antibody to S. pyogenes also reacted with a monoclonal antibody to ventricular myosin. Adsorption of the antibody to streptococci with S. pyogenes simultaneously removed reactivity of the antibody for either S. pyogenes or myosin. These results indicate that myosin shares immunodeterminants with a component of S. pyogenes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krisher, K -- Cunningham, M W -- New York, N.Y. -- Science. 1985 Jan 25;227(4685):413-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2578225" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens, Bacterial/*immunology ; Cross Reactions ; Epitopes/immunology ; Humans ; Myocardium/*immunology ; Myosins/*immunology ; Rabbits ; Streptococcus pyogenes/*immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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