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  • Kinetics  (59)
  • Cricetinae
  • American Association for the Advancement of Science (AAAS)  (87)
  • 1980-1984  (87)
  • 1983  (31)
  • 1982  (56)
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  • 1980-1984  (87)
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  • 1
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    Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, K -- Briggs, A H -- Elston, S F -- DeLallo, L -- Sheridan, P J -- Sar, M -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1425-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Ganglia/*drug effects ; Cricetinae ; Endorphins/*analysis ; Enkephalin, Leucine ; Enkephalins/*analysis/metabolism ; Ethanol/metabolism/*pharmacology ; Mesocricetus ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Micromolar affinity benzodiazepine receptors: identification and characterization in central nervous system (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Receptors that selectively bind micromolar concentrations of benzodiazepines are present in rat brain membrane. These micromolar receptors exhibit saturable, stereospecific binding, and the potency of benzodiazepine binding to these receptors is correlated with the ability of the benzodiazepines to inhibit maximum electric shock-induced convulsions. Benzodiazepine receptors with nanomolar affinity differ from the micromolar receptors in their binding, kinetic, and pharmacologic characteristics. The micromolar receptors also bind phenytoin, a non-benzodiazepine anticonvulsant. These results provide evidence for a distinct class of clinically relevant benzodiazepine receptors that may regulate neuronal excitability and anticonvulsant activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowling, A C -- DeLorenzo, R J -- NS 1352/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1247-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281893" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism/pharmacology ; Benzodiazepinones/metabolism ; Brain/*metabolism ; Calmodulin/antagonists & inhibitors ; Diazepam/metabolism ; Kinetics ; Ligands ; Protein Kinase Inhibitors ; Rats ; Receptors, Drug/*metabolism ; Receptors, GABA-A ; Structure-Activity Relationship
    Print ISSN: 0036-8075
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  • 4
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    Artificial enzymes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-05
    Description: Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, R -- New York, N.Y. -- Science. 1982 Nov 5;218(4572):532-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123255" target="_blank"〉PubMed〈/a〉
    Keywords: Catalysis ; Cyclodextrins ; *Enzymes ; Kinetics ; Models, Chemical ; Ribonucleases ; Structure-Activity Relationship ; Substrate Specificity ; Transaminases
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Long-term synaptic potentiation in the superior cervical ganglion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, T H -- McAfee, D A -- 12116/PHS HHS/ -- NS 16576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Sympathetic/*physiology ; Kinetics ; Learning/*physiology ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-06
    Description: Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bump, E A -- Yu, N Y -- Brown, J M -- CA-15201/CA/NCI NIH HHS/ -- CM-87207/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):544-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089580" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anoxia ; Cell Survival/drug effects/*radiation effects ; Cells, Cultured ; Cricetinae ; Cricetulus ; Drug Synergism ; Glutathione/*metabolism ; Maleates/administration & dosage ; Mice ; Mice, Inbred BALB C ; Misonidazole/administration & dosage ; Neoplasms, Experimental/metabolism ; *Oxygen Consumption
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Studies of isolated islets labeled with radioactive leucine show that glucose at a critical time "marks" islets in such a way as to cause preferential release of newly synthesized insulin. The preferential release of insulin from marked islets is relatively independent of subsequent secretagogues or rates of insulin secretion. Previous kinetic studies have indicated that the critical time at which marking occurs is after proinsulin biosynthesis but before the secretory event. Thus, secretory cells may regulate the diversion of newly synthesized material for immediate release as it is approaching or transiting the Golgi apparatus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, G -- Gishizky, M L -- Grodsky, G M -- AM 01410/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):56-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181562" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; Animals ; Glucose/*pharmacology ; In Vitro Techniques ; Insulin/biosynthesis/*secretion ; Islets of Langerhans/drug effects/*secretion ; Kinetics ; Leucine ; Potassium/pharmacology ; Tolbutamide/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA and apomorphine was more potent than L-(phenylisopropyl)adenosine and apomorphine in eliciting rotation, suggesting the involvement of adenosine receptors of the Ra type. The response was reduced when 2',5'-dideoxyadenosine was injected along with NECA into the caudate nucleus or when theorphylline was given intraperitoneally. Higher doses of apomorphine elicited a self-mutilatory response after the injection of NECA into the caudate nucleus. These results suggest that adenosine may be involved in the modulation of dopaminergic function in the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Green, R D -- Proudfit, H K -- Yeung, S M -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):58-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123218" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/administration & dosage/*analogs & derivatives/pharmacology ; Adenosine-5'-(N-ethylcarboxamide) ; Animals ; Apomorphine/pharmacology ; Caudate Nucleus/*physiology ; Corpus Striatum/*physiology ; Dopamine/*physiology ; Injections ; Kinetics ; Male ; Motor Activity/drug effects ; Rats ; Rats, Inbred Strains ; Rotation ; Vasodilator Agents/*pharmacology
    Print ISSN: 0036-8075
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  • 9
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    Lung fibrosis and emphysema: divergent responses to a common injury? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, beta-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niewoehner, D E -- Hoidal, J R -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):359-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089570" target="_blank"〉PubMed〈/a〉
    Keywords: Aminopropionitrile/pharmacology ; Animals ; Cadmium/pharmacology ; Cadmium Chloride ; Collagen/biosynthesis ; Connective Tissue/metabolism ; Cricetinae ; Elastin/biosynthesis ; Female ; Intubation, Intratracheal ; Lung/pathology ; Mesocricetus ; Pulmonary Emphysema/*chemically induced/pathology ; Pulmonary Fibrosis/*chemically induced/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: Administration of the hepatic carcinogen aflatoxin B1 to experimental animals results in covalent binding to liver mitochondrial DNA at concentrations three to four times higher than nuclear DNA. The concentration of carcinogen adducts in mitochondrial DNA remains unchanged even after 24 hours, possible because of lack of excision repair. Similarly, mitochondrial transcription and translation remain inhibited up to 24 hours suggesting long-term effects of aflatoxin B1 on the mitochondrial genetic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niranjan, B G -- Bhat, N K -- Avadhani, N G -- CA-22762/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797067" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxin B1 ; Aflatoxins/*metabolism ; Animals ; DNA, Mitochondrial/*metabolism ; Kinetics ; Liver Neoplasms/*chemically induced/metabolism ; Male ; Mitochondria, Liver/*metabolism ; Neoplasms, Experimental/chemically induced ; Protein Biosynthesis/drug effects ; Rats ; Transcription, Genetic/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto-Sampedro, M -- Lewis, E R -- Cotman, C W -- Manthorpe, M -- Skaper, S D -- Barbin, G -- Longo, F M -- Varon, S -- AG-00538/AG/NIA NIH HHS/ -- MH-19691/MH/NIMH NIH HHS/ -- NS-16349/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):860-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100931" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/physiology ; Animals ; Brain/*physiology ; Brain Injuries/*physiopathology ; Cell Survival/drug effects ; Cells, Cultured ; Cholinergic Fibers/physiology ; Kinetics ; Nerve Growth Factors/*metabolism/pharmacology ; *Nerve Regeneration ; Rats ; Rats, Inbred Strains ; Wound Healing
    Print ISSN: 0036-8075
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  • 12
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    Norethisterone, a major ingredient of contraceptive pills, is a suicide inhibitor of estrogen biosynthesis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: Norethisterone (17 alpha-ethynyl-19-nortestosterone) is an effective irreversible inhibitor of estrogen synthetase (aromatase), the enzyme responsible for the conversion of androgens to estrogens, even at a 2 X 10(-6) molar concentration. This irreversible inactivation, which is directed toward the active site of aromatase and requires the cofactor-reduced nicotinamide adenine dinucleotide phosphate, is both time- and concentration-dependent. Ethisterone (17 alpha-ethynyltestosterone), in contrast, is not a suicide inhibitor of aromatase even at concentrations of 10(-4) molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Osawa, Y -- Yarborough, C -- HDO4945/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1249-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058343" target="_blank"〉PubMed〈/a〉
    Keywords: *Aromatase Inhibitors ; Binding Sites/drug effects ; Contraceptives, Oral/*pharmacology ; Estrogens/*biosynthesis ; Female ; Humans ; Kinetics ; Microsomes/enzymology ; Norethindrone/*pharmacology ; Oxidoreductases/*antagonists & inhibitors ; Placenta/enzymology ; Pregnancy
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  • 13
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    Lethal effect of phenothiazine neuroleptics on the pathogenic protozoan Leishmania donovani (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, R D -- Manian, A A -- Harcus, J L -- Hall, D -- Hewlett, E L -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124040" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology/therapeutic use ; Chlorpromazine/pharmacology ; Cricetinae ; Humans ; Leishmania/*drug effects ; Leishmaniasis, Visceral/*drug therapy ; Macrophages/microbiology ; Mesocricetus
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  • 14
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    Congenital malformations induced by laetrile (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-19
    Description: Laetrile administered orally ot pregnant hamsters caused skeletal malformations in the offspring, but intravenous laetrile filed to result in embryopathic effects. Oral laetrile significantly increased in situ cyanide concentrations, while intravenous laetrile did not. Thiosulfate administration protected embryos from the teratogenic effects of oral laetrile. The embryopathic effects of oral laetrile appear to be due to cyanide released by bacterial beta-glucosidase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willhite, C C -- New York, N.Y. -- Science. 1982 Mar 19;215(4539):1513-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063858" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*etiology ; Administration, Oral ; Amygdalin/administration & dosage/metabolism/*toxicity ; Animals ; Cricetinae ; Female ; Injections, Intravenous ; Pregnancy
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  • 15
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    Translational efficiency of transfer RNA's: uses of an extended anticodon (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-12
    Description: Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. the anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarus, M -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):646-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753149" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Escherichia coli/genetics ; Kinetics ; Nucleic Acid Conformation ; *Protein Biosynthesis ; RNA, Transfer/*genetics ; Ribosomes/metabolism ; Structure-Activity Relationship ; Suppression, Genetic
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  • 16
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    Time course of alpha-flupenthixol action explains "response artifacts" of neuroleptic action on brain stimulation reward (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1983 Dec 16;222(4629):1251-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Flupenthixol/*pharmacology ; Hypothalamus/*drug effects ; Kinetics ; Rats ; *Reward ; Self Stimulation/*drug effects ; Thioxanthenes/*pharmacology
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  • 17
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    Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-29
    Description: Suitably brief pulses of selectively absorbed optical radiation can cause selective damage to pigmented structures, cells, and organelles in vivo. Precise aiming is unnecessary in this unique form of radiation injury because inherent optical and thermal properties provide target selectivity. A simple, predictive model is presented. Selective damage to cutaneous microvessels and to melanosomes within melanocytes is shown after 577-nanometer (3 x 10(-7) second) and 351-nanometer (2 x 10(-8) second) pulses, respectively. Hemodynamic, histological, and ultrastructural responses are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, R R -- Parrish, J A -- R01025395/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Hot Temperature ; Humans ; *Laser Therapy ; Melanins/metabolism ; Melanocytes/ultrastructure ; Microcirculation/surgery ; Microscopy, Electron ; Microsurgery/*methods
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  • 18
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    A polypeptide secreted by transformed cells that modulates human plasminogen activator production (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    High efficiency DNA-mediated transformation of primate cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-05
    Description: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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  • 20
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    Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harlan, R E -- Shivers, B D -- Pfaff, D W -- HD-05585/HD/NICHD NIH HHS/ -- HD-05737/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828874" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Animals ; Castration ; Cerebral Cortex/drug effects/*physiology ; Cosyntropin/pharmacology ; Estradiol/pharmacology ; Female ; Growth Hormone/pharmacology ; Immune Sera ; Kinetics ; Mesencephalon/*physiology ; Oxytocin/pharmacology ; Posture ; Prolactin/administration & dosage/*pharmacology ; Rats ; Sexual Behavior, Animal/*drug effects ; Vasopressins/pharmacology
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  • 21
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    The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-12-23
    Description: Endotoxin-free thymosin fraction 5 elevated corticotropin, beta-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and beta-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Healy, D L -- Hodgen, G D -- Schulte, H M -- Chrousos, G P -- Loriaux, D L -- Hall, N R -- Goldstein, A L -- CA 24974/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318312" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Dose-Response Relationship, Drug ; Endorphins/blood ; Female ; Hydrocortisone/blood ; Kinetics ; Macaca fascicularis ; Thymectomy ; Thymosin/analogs & derivatives/*pharmacology ; Thymus Gland/*physiology ; beta-Endorphin
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  • 22
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    Implication of nonlinear kinetics on risk estimation in carcinogenesis (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-04
    Description: Efforts in estimating carcinogenic risk in humans from long-term exposure to chemical carcinogens have centered on the problem of low-dose extrapolation. For chemicals with metabolites that interact with DNA, it may be more meaningful to relate tumor response to the concentration of the DNA adducts in the target organ rather than to the applied dose. Many data suggest that the relation between tumor response and concentration of DNA adducts in the target organ may be linear. This implies that the nonlinearities of the dose-response curve for tumor induction may be due to the kinetic processes involved in the formation of carcinogen metabolite--DNA adducts. Of particular importance is the possibility that the kinetic processes may show a nonlinear "hockey-stick" like behavior which results from saturation of detoxification or DNA repair processes. The mathematical models typically used for low-dose extrapolation are shown potentially to overestimate risk by several orders of magnitude when nonlinear kinetics are present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoel, D G -- Kaplan, N L -- Anderson, M W -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1032-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*administration & dosage ; Cell Transformation, Neoplastic/*drug effects ; DNA, Neoplasm/genetics ; Dose-Response Relationship, Drug ; Humans ; Kinetics ; Models, Biological ; Neoplasms/*chemically induced ; Risk
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  • 23
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    Heme-heme orientation and electron transfer kinetic behavior of multisite oxidation-reduction enzymes (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-11-25
    Description: Analysis of the polarized single-crystal absorption spectra of cytochrome cd1 of Pseudomonas aeruginosa shows that the heme c and heme d1 groups in each subunit are oriented perpendicularly to each other in both oxidized and reduced forms of the enzyme. These results, together with those of previous kinetic studies, indicate that a perpendicular heme-heme orientation may be an important factor in specifying kinetically slow steps in a sequential series of electron transfer reactions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makinen, M W -- Schichman, S A -- Hill, S C -- Gray, H B -- 1-T32-HD-07009/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 25;222(4626):929-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6415814" target="_blank"〉PubMed〈/a〉
    Keywords: *Cytochromes ; *Electron Transport ; *Heme ; Kinetics ; *Nitrite Reductases ; Pseudomonas aeruginosa/enzymology ; Spectrum Analysis
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  • 24
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-03
    Description: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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  • 25
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    Waterlogged molecules (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-12-09
    Description: Measurements of vapor pressures over their aqueous solutions indicate that organic compounds show profound differences in hydrophilic character. These differences are of such magnitude as to suggest an important role for changing solvation in determining free energy changes associated with metabolic transformations in water, and in governing structural equilibria of proteins and other large molecules in water. When two or more functional groups are present within the same solute molecule, their combined effects on its free energy of solvation are commonly additive. Striking departures from additivity, observed in certain cases, indicate the existence of special interactions between different parts of a solute molecule and the water that surrounds it. Similar considerations presumably apply to activated intermediates in the interconversion of biological materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfenden, R -- GM 18325/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1087-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6359416" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Organic ; Enzymes/physiology ; Kinetics ; Metabolism ; Nucleic Acid Conformation ; Nucleic Acids/physiology ; Organic Chemistry Phenomena ; Protein Conformation ; Solvents ; Water/*physiology
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  • 26
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    Noninvasive observations of fluorinated anesthetics in rabbit brain by fluorine-19 nuclear magnetic resonance (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-28
    Description: Fluorinated anesthetics were observed noninvasively in the brain of intact rabbits with fluorine-19 nuclear magnetic resonance spectroscopy. High-resolution fluorine-19 spectra of halothane, methoxyflurane, and isoflurane were obtained with a surface coil centered over the calvarium. Elimination of halothane from the brain was also monitored by this technique. Residual fluorine-19 signals from halothane (or a metabolite) could be detected as long as 98 hours after termination of anesthesia. These observations demonstrate the feasibility of using this technique to study the fate of fluorinated anesthetics in live mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyrwicz, A M -- Pszenny, M H -- Schofield, J C -- Tillman, P C -- Gordon, R E -- Martin, P A -- GM 29520/GM/NIGMS NIH HHS/ -- K04 GM 00503/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):428-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623084" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Halothane/*metabolism ; Isoflurane/*metabolism ; Kinetics ; Magnetic Resonance Spectroscopy ; Methoxyflurane/*metabolism ; Methyl Ethers/*metabolism ; Rabbits
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  • 27
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 28
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    Rapid degradation of "new" acetylcholine receptors at neuromuscular junctions (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-07
    Description: Acetylcholine receptors at innervated neuromuscular junctions are very stable, with half-lives reported to be 6 to 13 days. Their turnover is described as a first-order process, implying a single population of receptors. In this study, two subpopulations of acetylcholine receptors at normally innervated junctions have been identified. One has a rapid turnover rate with a half-life of 18.7 hours, similar to that of extrajunctional receptors, and the other has a slow turnover rate with a half-life of 12.4 days. The rapidly turned over subpopulation represents approximately 20 percent of the total junctional receptors. This finding may account for the discrepancies in previous reports of turnover rates and may explain the rapid reversibility in vivo of agents that "irreversibly" block acetylcholine receptors. This finding also implies that the synthesis rate of junctional acetylcholine receptors may be higher than previous estimates. The rapidly turned-over subpopulation may represent receptors that were newly inserted into the neuromuscular junction and that were not yet stabilized by an influence of the motor nerve.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, E F -- Drachman, D B -- 5 P01 NS10920/NS/NINDS NIH HHS/ -- 5 R01 HD04817/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623057" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bungarotoxins ; Diaphragm ; Kinetics ; Mice ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/biosynthesis/classification/*metabolism ; Synaptic Membranes/metabolism
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    Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-02-25
    Description: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Senger, D R -- Galli, S J -- Dvorak, A M -- Perruzzi, C A -- Harvey, V S -- Dvorak, H F -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):983-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascites/physiopathology ; Ascitic Fluid/physiology ; *Capillary Permeability ; Cricetinae ; Guinea Pigs ; Mice ; Neoplasms, Experimental/*physiopathology
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-08
    Description: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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    Tension transients in single isolated smooth muscle cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Tension transients were recorded in a single smooth muscle cell. The transient contains a linear elastic response and a biphasic recovery that appear to originate from the cross-bridges. A comparison of transients in smooth and fast skeletal muscle fibers suggests that the cross-bridge in smooth muscle is more compliant than the cross-bridge in striated muscle and that transitions between several cross-bridge states occur more slowly in smooth muscle than in striated muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warshaw, D M -- Fay, F S -- HL 05770/HL/NHLBI NIH HHS/ -- HL 14523/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1438-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828870" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; In Vitro Techniques ; Kinetics ; *Muscle Contraction ; Muscle Relaxation ; Muscle, Smooth/*physiology ; Muscles/physiology ; Stress, Mechanical
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  • 32
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    Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-18
    Description: Several lines of evidence suggest that there might be immunologic cross-reactivity between the thyroid plasma membrane in humans and antigenic determinants in the enteric pathogen Yersinia enterocolitica. Studies were therefore performed to determine whether Y. enterocolitica, like the thyroid membrane, contains a thyrotropin binding site. A saturable binding site for bovine thyrotropin was indeed demonstrable, particularly in preparations of the organism that have been treated with ethylenediaminetetraacetate and lysozyme. Hormonal specificity of the binding site, as judged from the inhibition of binding of 125I-labeled bovine thyrotropin, was similar to that of the thyrotropin receptor in human thyroid tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, M -- Ingbar, S H -- Winblad, S -- Kasper, D L -- AM 18416/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1331-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298936" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Binding, Competitive ; Kinetics ; Receptors, Cell Surface/*metabolism ; Receptors, Thyrotropin ; Thyrotropin/*metabolism ; Yersinia enterocolitica/*metabolism
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    Proton nuclear magnetic resonance of intact Friend leukemia cells: phosphorylcholine increase during differentiation (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: Proton nuclear magnetic resonance of intact Friend leukemia cells was used to analyze their erythroid-like differentiation. The technique, which requires only 10(3) to 10(9) cells and approximately 2 minutes for acquisition of each spectrum, demonstrated the occurrence of many signal changes during differentiation. With cell extracts, 64 signals were assigned to 12 amino acids and 19 other intermediary metabolites, and a dramatic signal change was attributed to a fourfold increase in cytoplasmic phosphorylcholines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agris, P F -- Campbell, I D -- 1-F33-GM07826/GM/NIGMS NIH HHS/ -- 1-FOG-TW00440/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079765" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Choline/*analogs & derivatives ; Kinetics ; Leukemia, Experimental/*physiopathology ; Magnetic Resonance Spectroscopy ; Mice ; Phosphorylcholine/*analysis
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
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    Simultaneous expression of globin genes for embryonic and adult hemoglobins during mammalian ontogeny (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: The dominant hemoglobin of the adult hamster was detected in yolk-sac erythroid cells, and its identity was confirmed by peptide mapping and by analysis of relevant peptides. Both the presence and active synthesis of two embryonic hemoglobins presumed to exist only in yolk-sac erythroid cells were detected in neonatal liver and spleen. Thus the time span of expression of both embryonic and adult globin genes during mammalian ontogeny may be considerably broader than presently believed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boussios, T -- Bertles, J F -- Clegg, J B -- AM 27116/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183746" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cricetinae ; Fetal Hemoglobin/genetics ; Gene Expression Regulation ; Globins/*genetics ; Liver/*physiology ; Spleen/physiology ; Yolk Sac/*physiology
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    Identification of a protein that purifies with the scrapie prion (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Purification of prions from scrapie-infected hamster brain yielded a protein that was not found in a similar fraction from uninfected brain. The protein migrated with an apparent molecular size of 27,000 to 30,000 daltons in sodium dodecyl sulfate polyacrylamide gels. The resistance of this protein to digestion by proteinase K distinguished it from proteins of similar molecular weight found in normal hamster brain. Initial results suggest that the amount of this protein correlates with the titer of the agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bolton, D C -- McKinley, M P -- Prusiner, S B -- AG02132/AG/NIA NIH HHS/ -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6815801" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*pathology ; Brain Chemistry ; Centrifugation, Density Gradient ; Cricetinae ; Electrophoresis, Polyacrylamide Gel ; Endopeptidase K ; Endopeptidases/metabolism ; Molecular Weight ; Nerve Tissue Proteins/*isolation & purification ; Prions/growth & development ; Scrapie/*pathology ; Sheep ; Virus Activation
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    Molecular biology of the sea urchin embryo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Research on the early development of the sea urchin offers new insights into the process of embryogenesis. Maternal messenger RNA stored in the unfertilized egg supports most of the protein synthesis in the early embryo, but the structure of maternal transcripts suggests that additional functions are also possible. The overall developmental patterns of transcription and protein synthesis are known, and current measurements describe the expression of specific genes, including the histone genes, the ribosomal genes, and the actin genes. Possible mechanisms of developmental commitment are explored for regions of the early embryo that give rise to specified cell lineages, such as the micromere-mesenchyme cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, E H -- Hough-Evans, B R -- Britten, R J -- GM20927/GM/NIGMS NIH HHS/ -- HD05753/HD/NICHD NIH HHS/ -- RR00986/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):17-26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178156" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/genetics ; Animals ; Base Sequence ; Blastocyst/physiology ; Embryo, Nonmammalian/*physiology ; Female ; Fertilization ; Gastrula/physiology ; Histones/genetics ; Kinetics ; Larva/physiology ; Polyribosomes/metabolism ; RNA/genetics ; RNA, Messenger/genetics ; Ribosomal Proteins/genetics ; Sea Urchins/*physiology ; Transcription, Genetic
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    Coupling of histone and DNA synthesis in the somatic cell cycle (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-01
    Description: The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delegeane, A M -- Lee, A S -- 2S07RR05356/RR/NCRR NIH HHS/ -- CA27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cricetinae ; DNA/biosynthesis ; *DNA Replication ; Histones/*biosynthesis ; Mutation
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  • 39
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    Multiplication of tobacco mosaic virus in tobacco leaf disks is inhibited by (2'-5) oligoadenylate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-25
    Description: The oligonucleotide (2'-5') oligoadenylate that is induced in interferon-treated animal cells protects plant tissue from infection by the tobacco mosaic virus. This inhibition of virus multiplication was obtained at concentrations comparable to those affecting protein synthesis and antiviral activities in animal cells. After treatment with (2'-5') oligoadenylate, the multiplicability of tobacco mosaic virus was reduced by 80 to 90 percent as measured by enzyme-linked immunosorbent assay. These results, along with the observation that human interferon protects tobacco tissue from infection by tobacco mosaic virus, indicate that plants and animals may have a common pathway for virus resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Devash, Y -- Biggs, S -- Sela, I -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1415-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178155" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*pharmacology ; Animals ; Cells, Cultured ; Interferons/pharmacology ; Kinetics ; Oligonucleotides/*pharmacology ; Oligoribonucleotides/*pharmacology ; Plants, Toxic ; Tobacco/microbiology ; Tobacco Mosaic Virus/*drug effects ; Virus Replication/drug effects
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    Events in the evolution of pre-proinsulin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-20
    Description: An extensive computer-assisted analysis of known pre-proinsulin coding sequences has shown correlations that can be interpreted as evidence for an intron-mediated juxtaposition of exons in the evolution of these genes. The evidence includes the discovery that the regions of the pre-proinsulin genes that code for the signal peptide consist of nearly tandem repeating units of nine base pairs. This pattern reappears in the C region of the genes after a large intron that occurs in three of the four genes analyzed. A model is proposed in which primordial insulin was coded for by two separate minigenes arising from a gene duplication, each with identical or nearly identical signal peptide coding regions. The minigenes fused into one transcriptional unit mediated by the large intron, and the signal peptide coding region of one of the putative minigenes evolved into the latter portion of the C peptide coding region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Douthart, R J -- Norris, F H -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):729-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100918" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Computers ; Cricetinae ; Disulfides ; Genes ; Humans ; Insulin ; Models, Genetic ; Proinsulin/*genetics ; Protein Precursors/*genetics ; Rats ; Repetitive Sequences, Nucleic Acid
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    Cystine transport is defective in isolated leukocyte lysosomes from patients with cystinosis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-24
    Description: The activity of a cystine transport system in lysosomes prepared from the leukocytes of patients with cystinosis was found to be deficient. In normal subjects, this system was resistant to N-ethylmaleimide and demonstrated saturation kinetics. Lysosomes from individuals heterozygous for cystinosis demonstrated a reduced maximum velocity for cystine egress from lysosomes. The rate of cystine escape from normal lysosomes was enhanced by adenosine triphosphate. The availability of normal and mutant lysosomes provides a means of investigating mechanisms of amino acid transport across lysosomal membranes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gahl, W A -- Bashan, N -- Tietze, F -- Bernardini, I -- Schulman, J D -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1263-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112129" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport/drug effects ; Carrier Proteins/metabolism ; Cysteine/metabolism ; Cystine/*metabolism ; Cystinosis/*metabolism ; Ethylmaleimide/pharmacology ; Humans ; Kinetics ; Leukocytes/*metabolism ; Lysosomes/metabolism
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Chromosomal assignment of the endogenous proto-oncogene C-abl (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage. This virus is a recombinant between the parental Moloney murine leukemia virus and a cellular gene termed C-abl. By analysis of a series of mouse x Chinese hamster hybrid celllines containing various mouse chromosomes, we have mapped the C-abl gene to mouse chromosome 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goff, S P -- D'Eustachio, P -- Ruddle, F H -- Baltimore, D -- CA-14051/CA/NCI NIH HHS/ -- GM-09966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293057" target="_blank"〉PubMed〈/a〉
    Keywords: Abelson murine leukemia virus/*genetics ; Animals ; B-Lymphocytes ; Cell Transformation, Viral ; Chromosome Mapping ; Cricetinae ; Cricetulus ; Hybrid Cells/analysis ; Leukemia Virus, Murine/*genetics ; Mice ; *Oncogenes
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    Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-17
    Description: The biosynthesis of melanin is initiated by the catalytic oxidation of tyrosine to dopa by tyrosinase in a reaction that requires dopa as a cofactor. Tyrosine then catalyzes the dehydrogenation of dopa to dopaquinone. The subsequent reactions can proceed spontaneously in vitro. Tyrosinase, purified from murine melanomas and the skins of brown mice, has now been shown to catalyze a third reaction in mammalian melanogenesis, namely the conversion of 5,6-dihydroxyindile to melanochrome. This reaction requires dopa as a cofactor and is inhibited by tyrosine. Conversely, 5,6-dihydroxyindole inhibits the oxidation of tyrosine to dopa, so that the relative concentrations of tyrosine and 5,6-dihydroxyindole within the mammalian pigment cell are capable of regulating melanogenesis in a previously unrecognized fashion. Tyrosinase has the unusual property of catalyzing three distinct reactions within a single biochemical pathway: the hydroxylation of a monophenol, the dehydrogenation of a catechol, and the dehydrogenation of a dihydroxyindole. The first and third of these reactions require dopa as a cofactor; in the second reaction, dopa is a substrate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korner, A -- Pawelek, J -- DA-01147/DA/NIDA NIH HHS/ -- DA-05186/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1163-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810464" target="_blank"〉PubMed〈/a〉
    Keywords: Catechol Oxidase/*metabolism ; Cells, Cultured ; Dihydroxyphenylalanine/metabolism ; Indoles/metabolism ; Kinetics ; Melanins/*biosynthesis ; Melanoma/enzymology ; Monophenol Monooxygenase/*metabolism ; Neoplasms, Experimental/enzymology ; Substrate Specificity ; Tyrosine/metabolism
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    Amplification and adaptation in regulatory and sensory systems (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- Goldbeter, A -- Stock, J B -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):220-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089556" target="_blank"〉PubMed〈/a〉
    Keywords: *Acclimatization ; *Adaptation, Physiological ; Animals ; Environment ; Kinetics ; Mathematics ; Models, Biological ; Models, Neurological ; Sense Organs/*physiology ; Sensory Receptor Cells/physiology
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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  • 47
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    Pituitary receptor site blockade by a gonadotropin-releasing hormone antagonist in vivo: mechanism of action (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Administration of a potent gonadotropin-releasing hormone (GnRH) antagonist [Nac-L-Ala1,pCl-D-Phe2,D-Trp3,6]GnRH as a single subcutaneous injection to castrated adult male rats reduced, by more than 90 percent, both serum luteinizing hormone concentrations and specific pituitary GnRH receptor binding. This effect persisted for 24 hours. The dissociation rate of the antagonist from pituitary membrane homogenates was fourfold slower than the dissociation rate of a potent agonist. The prolonged in vivo inhibition of pituitary GnRH receptor binding and luteinizing hormone secretion by the GnRH antagonist may be mediated by the slower dissociation rate of the antagonist from its specific pituitary membrane receptor site.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heber, D -- Dodson, R -- Swerdloff, R S -- Channabasavaiah, K -- Stewart, J M -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):420-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Follicle Stimulating Hormone/secretion ; Gonadotropin-Releasing Hormone/*antagonists & inhibitors ; Kinetics ; Luteinizing Hormone/*secretion ; Male ; Pituitary Gland/*metabolism ; Rats ; Receptors, Cell Surface/*drug effects/metabolism ; Receptors, LHRH
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    Rat pro-opiomelanocortin contains sulfate (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoshina, H -- Hortin, G -- Boime, I -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):63-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6283633" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*biosynthesis ; Amino Acid Sequence ; Animals ; In Vitro Techniques ; Kinetics ; Leucine ; Pituitary Gland/*metabolism ; Pituitary Hormones, Anterior/*biosynthesis ; Pro-Opiomelanocortin ; Protein Precursors/*biosynthesis ; Radioisotope Dilution Technique ; Rats ; Sulfur Radioisotopes ; Sulfuric Acids/*metabolism ; Tritium
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    Hydrolysis of nerve gas by squid-type diisopropyl phosphorofluoridate hydrolyzing enzyme on agarose resin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-05
    Description: An enzyme purified from squid nerve that hydrolyzes the cholinesterase inhibitor diisopropyl phosphorofluoridate (DFP) has now been coupled to agarose beads. A column of this agarose-DFPase hydrolyzes the nerve gas 1,2,2-trimethylpropyl methylphosphonofluoridate (Soman). Although the more inhibitory of the four diastereoisomers of Soman are hydrolyzed least rapidly, a column of sufficient length will accomplish 95 percent hydrolysis whether measured by fluoride release or loss of cholinesterase-inhibiting power. The results suggest a means for detoxifying unwanted chemical warfare agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoskin, F C -- Roush, A H -- ES-02116/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1255-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7058344" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Decapodiformes/*enzymology ; Enzymes, Immobilized ; Isoflurophate/*metabolism ; Kinetics ; Molecular Weight ; Organophosphorus Compounds/*metabolism ; Soman/*metabolism ; Stereoisomerism ; Substrate Specificity
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    Colloidal solution of water in organic solvents: a microheterogeneous medium for enzymatic reactions (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: To simulate in vitro the conditions under which enzymes act in vivo, enzyme molecules have been entrapped in hydrated reverse micelles of a surfactant in organic solvents. In this system the catalytic activity of one of the enzymes studied (peroxidase) became much higher than in water, and the specificity of the other enzyme (alcohol dehydrogenase) was dramatically altered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinek, K -- Levashov, A V -- Khmelnitsky, Y L -- Klyachko, N L -- Berezin, I V -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6753152" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohol Oxidoreductases/metabolism ; *Catalysis ; Enzymes/*metabolism ; Kinetics ; Micelles ; Peroxidases/metabolism ; Solvents ; *Water
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    Light-induced modification of Drosophila retinal polypeptides in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: The effect of light on the polypeptide map profile of the Drosophila eye preparation was examined by two-dimensional polyacrylamide gel electrophoresis. The results show (i) that illuminating the living fly reversibly changes the isoelectric points of three classes of polypeptides specific for the photoreceptor layer and (ii) that the norpA mutation, which prevents the generation of the receptor potential, blocks the modifications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsumoto, H -- O'Tousa, J E -- Pak, W L -- EY 00033/EY/NEI NIH HHS/ -- EY 07008/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):839-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drosophila/*metabolism ; Electrophoresis, Polyacrylamide Gel ; Eye Proteins/*metabolism ; Isoelectric Point ; Kinetics ; *Light ; Mutation ; Peptides/*metabolism ; Photoreceptor Cells/metabolism ; Retina/*metabolism
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    High-affinity choline transport in proteoliposomes derived from rat cortical synaptosomes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Functional high- and low-affinity choline transport processes from rat cortical plasma membranes were reconstituted in phosphatidylcholine bilayer liposomes. The high-affinity choline transporter demonstrated a pharmacological profile and ion dependency that were identical to those of intact synaptosomes. This preparation may be used to further characterize choline transport and, with appropriate supplementation, to investigate the release of acetylcholine in the absence of synaptic vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer, E M -- Cooper, J R -- NS 09836/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):843-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100928" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Animals ; Biological Transport ; Cell Membrane/metabolism ; Chlorides/metabolism ; Choline/*metabolism ; Kinetics ; Lipid Bilayers/metabolism ; Liposomes/*metabolism ; Phosphatidylcholines/metabolism ; Rats ; Sodium/metabolism ; Synaptosomes/*metabolism
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    Cysteamine: a potent and specific depletor of pituitary prolactin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-30
    Description: Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millard, W J -- Sagar, S M -- Landis, D M -- Martin, J B -- AM 26252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 30;217(4558):452-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Cysteamine/*pharmacology ; Domperidone/pharmacology ; Dose-Response Relationship, Drug ; Kinetics ; Male ; Pituitary Gland, Anterior/*metabolism ; Prolactin/analysis/*metabolism/secretion ; Rats ; Receptors, Dopamine/physiology ; Spiperone/pharmacology
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    Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morphis, L -- Constantopoulos, A -- Matsaniotis, N -- Papaphilis, A -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):156-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123226" target="_blank"〉PubMed〈/a〉
    Keywords: Aminophylline/pharmacology ; Animals ; Animals, Newborn ; Bilirubin/metabolism/*pharmacology ; Brain/drug effects/*metabolism ; Kinetics ; Nerve Tissue Proteins/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rabbits
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    Splitting of the circadian rhythm of activity is abolished by unilateral lesions of the suprachiasmatic nuclei (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-26
    Description: The circadian rhythm of activity in vertebrates often splits into two components after continuous exposure to constant light. This observation suggests that at least two circadian pacemakers underlie the activity rhythm. After unilateral ablation of the hypothalamic suprachiasmatic nuclei in hamsters, the splitting phenomenon was eliminated and a single rhythm of activity was established. The period of the new circadian activity rhythm different from the periods of the split rhythm and that preceding the split. These results suggest an interaction between the bilaterally paired suprachiasmatic nuclei in the generation of the circadian rhythm of activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickard, G E -- Turek, F W -- HD-09885/HD/NICHD NIH HHS/ -- HD-12622/HD/NICHD NIH HHS/ -- K04 HD-00249/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1119-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063843" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Circadian Rhythm ; Cricetinae ; Functional Laterality ; Hypothalamus/*physiology ; Motor Activity ; Supraoptic Nucleus/*physiology
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    Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The activity of nucleoside triphosphatase, an enzyme that regulates nuclear messenger RNA transport, was measured in highly purified nuclear envelopes isolated from rat liver. Addition of picomolar concentrations of insulin to freshly prepared nuclear envelopes directly increased the enzyme activity. The major effect of insulin on this enzyme was to increase the maximum velocity of its activity; no significant effects were seen on the affinity constant. These studies raise the possibility, therefore, that the nuclear envelope is a site where insulin regulates nuclear functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Purrello, F -- Vigneri, R -- Clawson, G A -- Goldfine, I D -- AM 26667/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):1005-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell-Free System ; Enzyme Activation/drug effects ; Insulin/*pharmacology ; Kinetics ; Liver/enzymology ; Nuclear Envelope/*enzymology ; Nucleoside-Triphosphatase ; Nucleotides/metabolism ; Phosphoric Monoester Hydrolases/*metabolism ; RNA, Messenger/metabolism ; Rats
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    Antidepressants alter cerebrovascular permeability and metabolic rate in primates (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-16
    Description: External detection of the annihilation radiation produced by water labeled with oxygen-15 was used to measure cerebrovascular permeability and cerebral blood flow in six rhesus monkeys. Use of oxygen-15 also permitted assessment of cerebral metabolic rate in two of the monkeys. Amitriptyline produced a dose-dependent, reversible increase in permeability at plasma drug concentrations which are therapeutic for depressed patients. At the same concentrations the drug also produced a 20 to 30 percent reduction in cerebral metabolic rate. At higher doses normal autoregulation of cerebral blood flow was suspended, but responsivity to arterial carbon dioxide was normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preskorn, S H -- Raichle, M E -- Hartman, B K -- HL-13851/HL/NHLBI NIH HHS/ -- NS-06833/NS/NINDS NIH HHS/ -- NS-17252/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):250-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089562" target="_blank"〉PubMed〈/a〉
    Keywords: Amitriptyline/*pharmacology ; Animals ; Blood Pressure/drug effects ; Blood-Brain Barrier/drug effects ; Brain/drug effects/*metabolism ; Capillaries/physiology ; Cerebrovascular Circulation/*drug effects ; Kinetics ; Macaca mulatta ; Permeability ; Regional Blood Flow/drug effects
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    Somatic cell genetics and gene families (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-05-27
    Description: The utility of somatic cell genetic analysis for the chromosomal localization of genes in mammals is well established. With the development of recombinant DNA probes and efficient blotting techniques that allow visualization of single-copy cellular genes, somatic cell genetics has been extended from the level of phenotypes expressed by whole cells to the level of the cellular genome itself. This extension has proved invaluable for the analysis of genes not readily expressed in somatic cell hybrids and for the study of multigene families, especially pseudogenes dispersed in different chromosomes throughout the genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉D'Eustachio, P -- Ruddle, F H -- GM-09966/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):919-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6573776" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Chromosome Mapping ; Chromosomes, Human ; Cricetinae ; Cricetulus ; DNA, Recombinant/metabolism ; Genes ; Genetic Markers ; Genetics ; Humans ; Hybrid Cells/metabolism ; Mice ; Polymorphism, Genetic ; RNA, Messenger/metabolism
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    Cell growth on liquid microcarriers (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Anchorage-dependent cell growth is demonstrated on microcarriers of fluorocarbon fluid formed by emulsification and stabilized with polylysine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keese, C R -- Giaever, I -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1448-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828872" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Division ; *Cell Physiological Phenomena ; Cells, Cultured ; Culture Media ; Emulsions ; Fluorocarbons ; Kinetics
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    Free-metal ion depletion by "Good's" buffers (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-19
    Description: Metal-ion affinity (formation) constants were determined for two "Good's" buffers, N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and N,N-bis(2-hydroxyethyl)glycine (bicine). The metal chelates formed undergo loss of an internal ligand (alcohol) proton (bicine) and undergo hydrolysis (bicine and TES) and dimerization reactions (TES). Bicine and TES buffer not only hydrogen ions but also metal ions. The metal complexes of "Good's" buffers also buffer hydrogen ions by secondary reactions. The consequences of these reactions are considered in relation to biomedical research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakon, R -- Krishnamoorthy, C R -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):749-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879173" target="_blank"〉PubMed〈/a〉
    Keywords: Apoenzymes ; *Buffers ; *Chelating Agents ; Glycine/analogs & derivatives ; Kinetics ; Metalloproteins ; Metals ; Tromethamine/analogs & derivatives
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    Phosphorylation of myosin light chains in mouse fast-twitch muscle associated with reduced actomyosin turnover rate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Phosphorylation of the 18,000-dalton light chains of the fast-twitch myosin in mouse extensor digitorum longus muscles was correlated with reduction in the rate of the actomyosin adenosinetriphosphatase in vivo, but neither of these changes occurred in the soleus muscle. These results suggest that actomyosin interactions can be down-regulated by a reversible covalent modification of myosin light chains, that a mechanism for thick-filament regulation occurs in vertebrate skeletal muscle, and that the expression of this regulation may be limited to a specific fiber type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crow, M T -- Kushmerick, M J -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):835-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285472" target="_blank"〉PubMed〈/a〉
    Keywords: Actomyosin/metabolism ; Adenosine Triphosphatases/metabolism ; Animals ; Energy Metabolism ; Kinetics ; Mice ; Muscle Contraction ; Muscle, Smooth/metabolism ; Muscles/*metabolism ; Myosin-Light-Chain Phosphatase ; Myosins/*metabolism ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation
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    H-2 histocompatibility region: influence on the murine glucocorticoid receptor and its response (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The influence of the H-2 histocompatibility complex on glucocorticoid receptor levels, and the biochemical response of glucocorticoid action measured as the degree of inhibition of prostaglandin production, has been studied in the mouse thymus and lung. The B10A (H-2a) strain of mice has significantly higher glucocorticoid receptor levels and a significantly greater biochemical response to glucocorticoid than the B10 (H-2b) strain, which differs from B10A within the H-2 complex only. Thus, the anti-inflammatory hormone response of glucocorticoids is correlated to hormone receptor level, both of which are influenced by the H-2 locus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gupta, C -- Goldman, A -- DE-0541/DE/NIDCR NIH HHS/ -- DE-4622/DE/NIDCR NIH HHS/ -- DE-5592/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1982 May 28;216(4549):994-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dexamethasone/metabolism/pharmacology ; Female ; Genetic Linkage ; H-2 Antigens/*genetics ; Kinetics ; Lung/metabolism ; *Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains ; Prostaglandins/biosynthesis ; Receptors, Glucocorticoid/*genetics ; Receptors, Steroid/*genetics ; Thymus Gland/metabolism
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    In vivo activation of zoxazolamine metabolism by flavone (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-25
    Description: The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate several-fold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a zenobiotic that is an activator of hepatic microsomal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lasker, J M -- Huang M-T -- Conney, A H -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1419-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089530" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cytochrome P-450 Enzyme System/metabolism ; Drug Combinations ; Drug Interactions ; Flavonoids/*pharmacology ; Hydroxylation ; Kinetics ; Microsomes, Liver/*metabolism ; Rats ; Zoxazolamine/*metabolism
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    Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: An influenza A reassortant virus that contained the hemagglutinin and neuraminidase genes of a virulent human virus, A/Udorn/72 (H3N2), and the six other influenza A virus genome segments from an avirulent avian virus, A/Mallard/New York/6750/78 (H2N2), was evaluated for its level of replication is squirrel monkeys and hamsters. In monkeys, the reassortant virus was as attenuated and as restricted in its level of replication in the upper and lower respiratory tract as its avian influenza virus parent. Nonetheless, infection with the reassortant induced significant resistant to challenge with virulent human influenza virus. In hamsters, the reassortant virus replicated to a level intermediate between that of its parents. These findings suggest that the nonsurface antigen genes of the avian parental virus are the primary determinants of restriction of replication of the reassortant virus in monkeys. Attenuation of the reassortant virus for primates is achieved by inefficient functioning of the avian influenza genes in primate cells, while antigenic specificity of the human influenza virus is provided by the neuraminidase and hemagglutinin genes derived from the human virus. This approach could lead to the development of a live influenza A virus vaccine that is attenuated for man if the avian influenza genes are similarly restricted in human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, B R -- Sly, D L -- Tierney, E L -- Hosier, N T -- Massicot, J G -- London, W T -- Chanock, R M -- Webster, R G -- Hinshaw, V S -- CA 21765/CA/NCI NIH HHS/ -- N01-AI-02649/AI/NIAID NIH HHS/ -- N01-NS-7-2375/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Surface/genetics ; Cricetinae ; Epitopes/genetics/immunology ; Hemagglutinins/genetics/immunology ; Influenza A virus/*genetics ; Influenza Vaccines/*immunology ; Neuraminidase/genetics/immunology ; Saimiri ; Vaccines, Attenuated/immunology
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    Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-24
    Description: Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced the differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, E M -- Meyer, W J -- Blalock, J E -- AM30046/AM/NIADDK NIH HHS/ -- HL20201/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1311-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183748" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*physiology ; Animals ; Corticosterone/*biosynthesis ; Dexamethasone/pharmacology ; *Hypophysectomy ; Interferons/biosynthesis ; Kinetics ; Lymph Nodes/*physiology ; Mice ; Newcastle Disease/*metabolism ; Time Factors
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    Interactions among converging sensory inputs in the superior colliculus (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-22
    Description: The responses of superior colliculus cells to a given sensory stimulus were influenced by the presence or absence of other sensory cues. By pooling sensory inputs, many superior colliculus cells seem to amplify the effects of subtle environmental cues in certain conditions, whereas in others, responses to normally effective stimuli can be blocked. The observations illustrate the dynamic, interactive nature of the multisensory inputs which characterize the deeper laminae of the superior colliculus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meredith, M A -- Stein, B E -- EY 04119/EY/NEI NIH HHS/ -- NS 06838/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 22;221(4608):389-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867718" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Animals ; Cats ; Cricetinae ; Neural Inhibition ; Photic Stimulation ; Sensory Thresholds ; Superior Colliculi/cytology/*physiology
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    A developmentally regulated neuraminidase activity in Trypanosoma cruzi (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: The human pathogen Trypanosoma cruzi (Y strain) contains a neuraminidase activity that varies widely in the different developmental stages of the parasite. The specific neuraminidase activity of infective trypomastigotes obtained from tissue culture and from the bloodstream of infected mice is 7 to 15 times higher than that of the acellular culture forms. Amastigotes were devoid of enzyme activity. The enzyme has a pH optimum of 6.0 to 6.5. Live trypanosomes released sialic acid from human erythrocytes and plasma glycoproteins. Several sialyl compounds were hydrolyzed by the parasite, but the best substrate was the protein orosomucoid. Erythrocytes from infected mice with T. cruzi parasitemia were agglutinated by peanut lectin and the hemagglutination titer was correlated with the degree of parasitemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pereira, M E -- IRO1-AI-18102-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1444-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338592" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Kinetics ; Neuraminidase/*metabolism ; Substrate Specificity ; Trypanosoma cruzi/enzymology/*growth & development
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    Activation of 2-aminofluorene by cultured plant cells (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-25
    Description: Cultured tobacco plant cells activated 2-aminofluorene to an agent mutagenic to Salmonella typhimurium strain TA98. The plant activation of 2-aminofluorene is heat-inactivated and may not involve solely cytochrome P-450. The kinetics of activation demonstrated both time- and concentration-dependent responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plewa, M J -- Weaver, D L -- Blair, L C -- Gentile, J M -- ES02384/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338591" target="_blank"〉PubMed〈/a〉
    Keywords: Biotransformation ; Cells, Cultured ; Fluorenes/*metabolism/pharmacology ; Kinetics ; Mutagenicity Tests ; Mutagens/*metabolism ; *Mutation ; *Plants, Toxic ; Salmonella typhimurium/drug effects ; Tobacco/*metabolism
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    Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-04-23
    Description: Two populations of receptors for gamma-aminobutyric acid, one with low- and the other with high-affinity characteristics, are detectable in frozen, thawed, Triton-treated synaptic membrane preparations from normal brain. It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites. Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Zeneroli, Z L -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280279" target="_blank"〉PubMed〈/a〉
    Keywords: Bicuculline/metabolism ; Binding, Competitive ; Brain/*metabolism ; Disease Models, Animal ; Galactosamine ; Hepatic Encephalopathy/*metabolism ; Humans ; Kinetics ; Receptors, Cell Surface/*metabolism ; Receptors, GABA-A ; Synaptic Membranes/metabolism ; Time Factors ; gamma-Aminobutyric Acid/*metabolism
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    DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birnboim, H C -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6276978" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/drug effects ; Cells, Cultured ; Cocarcinogenesis ; *Dna ; Free Radicals ; Humans ; Kinetics ; Leukocytes/*drug effects ; Oxygen Consumption/drug effects ; Phorbols/*pharmacology ; Superoxides/metabolism ; Tetradecanoylphorbol Acetate/*pharmacology
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    Endotoxin-stimulated opioid peptide secretion: two secretory pools and feedback control in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-27
    Description: Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of beta-endorphin to beta-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in beta-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carr, D B -- Bergland, R -- Hamilton, A -- Blume, H -- Kasting, N -- Arnold, M -- Martin, J B -- Rosenblatt, M -- AM 07028-06/AM/NIADDK NIH HHS/ -- AM 26252/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):845-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285473" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Endorphins/blood/cerebrospinal fluid/*secretion ; Endotoxins/*pharmacology ; Escherichia coli ; Feedback ; Kinetics ; Naloxone/pharmacology ; Peptide Fragments/blood/cerebrospinal fluid ; Sheep ; beta-Endorphin
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    Reproducing results (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kark, P -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089541" target="_blank"〉PubMed〈/a〉
    Keywords: *Ethics ; Friedreich Ataxia/enzymology ; Humans ; Kinetics ; *National Institutes of Health (U.S.) ; Pyruvate Dehydrogenase Complex/metabolism ; United States
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    Numbers of receptor sites from Scatchard graphs: facts and fantasies (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-09-24
    Description: Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287580" target="_blank"〉PubMed〈/a〉
    Keywords: Kinetics ; Ligands/metabolism ; Receptors, Cell Surface/*metabolism ; Statistics as Topic/*methods
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    Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-05-28
    Description: The presence of synthetic ovine corticotropin-releasing factor leads to a rapid and marked stimulation of adenosine 3', 5'-monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture. The increase, observed as early as 60 seconds after the addition of corticotropin-releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin-releasing factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Labrie, F -- Veilleux, R -- Lefevre, G -- Coy, D H -- Sueiras-Diaz, J -- Schally, A V -- New York, N.Y. -- Science. 1982 May 28;216(4549):1007-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281886" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*secretion ; Animals ; Corticotropin-Releasing Hormone/*pharmacology ; Cyclic AMP/*metabolism ; Female ; Kinetics ; Pituitary Gland, Anterior/*drug effects/*metabolism ; Rats
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    Are ions involved in the gating of calcium channels? (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: The rates of activation and deactivation of the currents carried by calcium, strontium, or barium ions through the voltage-sensitive calcium channel of Paramecium are different. The differences cannot be attributed to complications due to internal ion concentration, calcium channel inactivation, potassium current activation, surface charge effects, or incomplete space clamping. The findings indicate participation of the divalent cations in the voltage-driven calcium channel gating process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saimi, Y -- Kung, C -- GM22714/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):153-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289432" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/metabolism ; Calcium/*metabolism ; Cell Membrane/physiopathology ; Ion Channels/*metabolism ; Kinetics ; Membrane Potentials ; Paramecium/*physiology ; Strontium/metabolism
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    beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-01
    Description: Extended analogs of adenosine triphosphate (ATP) and guanosine triphosphate (GTP), in which a peroxide bridge replaces the terminal bridge-oxygen of the triphosphate chain, have been synthesized. The ability of beta, gamma-peroxy-ATP to inhibit or substitute for ATP in representative enzyme systems and that of beta, gamma-peroxy-GTP, for FTP in protein synthesis was tested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosendahl, M S -- Leonard, N J -- GM-05829/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):81-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053563" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Guanosine Triphosphate/*analogs & derivatives/chemical synthesis/metabolism ; Kinetics ; Peroxides ; Protein Biosynthesis/drug effects ; Structure-Activity Relationship
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    Tritiated imipramine binding sites are decreased in the frontal cortex of suicides (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: Binding characteristics of tritiated imipramine were determined in the frontal cortex of suicides and well-matched controls. Maximal binding was significantly lower in brains from the suicides. This finding is consistent with reports of decreased tritiated imipramine binding in the platelets of patients diagnosed as having a major affective disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, M -- Virgilio, J -- Gershon, S -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1337-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079769" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Carrier Proteins ; Cerebral Cortex/*metabolism ; Humans ; Imipramine/*metabolism ; Kinetics ; Middle Aged ; Receptors, Drug/*metabolism ; Reference Values ; *Suicide ; Tritium
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    Biotin enhances guanylate cyclase activity (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vesely, D L -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6123152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotin/analogs & derivatives/*pharmacology ; Cerebellum/enzymology ; Colon/enzymology ; Guanylate Cyclase/*metabolism ; Kidney/enzymology ; Kinetics ; Liver/enzymology ; Myocardium/enzymology ; Rats ; Rats, Inbred Strains
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    Transmission of Oropouche virus from man to hamster by the midge Culicoides paraensis (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-03-05
    Description: Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log10 of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinheiro, F P -- Travassos da Rosa, A P -- Gomes, M L -- LeDuc, J W -- Hoch, A L -- New York, N.Y. -- Science. 1982 Mar 5;215(4537):1251-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6800036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bunyaviridae/*physiology ; Bunyaviridae Infections/*transmission ; Ceratopogonidae/*microbiology ; Cricetinae ; Disease Models, Animal ; Humans ; Insect Vectors/*microbiology ; Simbu virus/*physiology
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    Myosin light chain phosphorylation does not modulate cross-bridge cycling rate in mouse skeletal muscle (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: An attempt was made to determine whether phosphorylation of the myosin light chain represents a thick filament-associated mechanism for modulating the rate of cross-bridge cycling in mouse skeletal muscle. When the degree of light chain phosphorylation was varied independently of tetanus duration, there was no correlation of phosphorylation with cross-bridge turnover rate, as measured by the shortening velocity of the muscle. It is concluded that in intact skeletal muscle phosphorylation of the myosin light chain does not in itself modulate cross-bridge cycling rate and that previously reported changes in cycling rate were due to other factors that may vary with tetanus duration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, T M -- Siegman, M J -- Mooers, S U -- Barsotti, R J -- AM 00973/AM/NIADDK NIH HHS/ -- HL 15835/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1167-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857239" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Kinetics ; Mice ; Muscle Contraction ; Muscles/*metabolism/physiology ; Myosins/*metabolism/physiology ; Phosphorylation ; Rats
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  • 81
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    Role for acetylcholine in mediating effects of light on reproduction (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-07
    Description: The length of day, or photoperiod, regulates the annual cycle of reproductive activity in the golden hamster. The inhibitory effects of a short-day photoperiod on testicular function were prevented by nighttime, but not daytime, intraventricular injections of carbachol, a cholinergic agonist. Short pulses of light during the night also block short-day induced testicular regression. The findings suggest that acetylcholine may play an important role in the mechanism through which information about the light-dark environment is transferred to the hypothalamic-pituitary-gonadal axis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Earnest, D J -- Turek, F W -- HD-00249/HD/NICHD NIH HHS/ -- HD-09885/HD/NICHD NIH HHS/ -- HD-12622/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):77-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849121" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*physiology ; Animals ; Carbachol/pharmacology ; Cricetinae ; *Light ; Male ; Mesocricetus ; *Reproduction ; Testis/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 82
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    Local differences in the amount of early cell death in neocortex predict adult local specializations (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-03-18
    Description: The amount of early cell loss in five neocortical areas was inversely related to adult numbers of neurons in those areas. Differential cell death predicted particularly the thickness of the upper cortical laminae; it was not related to neuron numbers in the lower laminae. Cell loss thus determines some features of local neocortical differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finlay, B L -- Slattery, M -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cell Survival ; Cerebral Cortex/*cytology/growth & development ; Cricetinae
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1 (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-12-16
    Description: Fragments of the recently cloned human gene for the beta subunit of nerve growth factor (beta-NGF) were used as hybridization probes in analyzing two sets of rodent-human somatic cell hybrids for the presence of human beta-NGF sequences. Results from the first set of hybrids assigned the human beta-NGF gene to chromosome 1 and ruled out the presence of sequences of comparable homology on any other chromosome. With the second set of hybrids, which contained seven different, but overlapping, regions of chromosome 1, the NGF locus was mapped to band 1p22.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Francke, U -- de Martinville, B -- Coussens, L -- Ullrich, A -- GM 26105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1248-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Banding ; Chromosome Mapping ; *Chromosomes, Human, 1-3 ; Cricetinae ; *Genes ; Humans ; Hybrid Cells ; Nerve Growth Factors/*genetics ; Nucleic Acid Hybridization ; Oncogenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 84
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    Sex differences in serotonin 1 receptor binding in rat brain (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-21
    Description: Male and female rats exhibit sex differences in binding by serotonin 1 receptors in discrete areas of the brain, some of which have been implicated in the control of ovulation and of gonadotropin release. The sex-specific changes in binding, which occur in response to the same hormonal (estrogenic) stimulus, are due to changes in the number of binding sites. Castration alone also affects the number of binding sites in certain areas. The results lead to the conclusion that peripheral hormones modulate binding by serotonin 1 receptors. The status of the serotonin receptor system may affect the reproductive capacity of an organism and may be related to sex-linked emotional disturbances in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischette, C T -- Biegon, A -- McEwen, B S -- AM06122/AM/NIADDK NIH HHS/ -- NS06080/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 21;222(4621):333-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623080" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Brain Mapping ; Castration ; Cell-Free System ; Estradiol/*pharmacology ; Female ; Glucosephosphate Dehydrogenase/metabolism ; Kinetics ; Male ; Pituitary Gland/enzymology ; Rats ; Receptors, Serotonin/drug effects/*metabolism ; *Sex Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 85
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    Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-25
    Description: The carcinogen aflatoxin B1 was reacted with a polymer of alternating deoxyguanine and deoxycytosine residues to determine the effect that adduct formation has on the conversion of this polymer from the right-handed B-DNA form found at low salt concentrations to the left-handed Z-DNA form found at high salt concentrations. Reaction with aflatoxin strongly inhibited the salt-induced conversion of this polymer from B-DNA to Z-DNA. This inhibition could be detected even at relatively low binding levels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nordheim, A -- Hao, W M -- Wogan, G N -- Rich, A -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6402818" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxin B1 ; Aflatoxins/*pharmacology ; Circular Dichroism ; DNA/*metabolism ; Kinetics ; Nucleic Acid Conformation ; Osmolar Concentration ; Sodium Chloride/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-07-01
    Description: With a synthetic oligonucleotide mixture as probe, complementary DNA clones of C-reactive protein were isolated from an adult human liver complementary DNA library. The clones ranged in size from 700 to 1100 base pairs and were identified by partial DNA sequence analysis. One complementary DNA clone was used as a probe for hybridization with human-rodent DNA's isolated from somatic cell hybrids and bound to nitrocellulose filters (Southern blot analysis) to assign the human C-reactive protein gene to chromosome 1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitehead, A S -- Bruns, G A -- Markham, A F -- Colten, H R -- Woods, D E -- AI15033/AI/NIAID NIH HHS/ -- HD4807/HD/NICHD NIH HHS/ -- HL22487/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857266" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; C-Reactive Protein/*genetics ; *Chromosome Mapping ; *Chromosomes, Human, 1-3 ; Cloning, Molecular ; Cricetinae ; DNA/*genetics/isolation & purification ; Genes ; Humans ; Hybrid Cells/metabolism ; Mice
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
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    Labeled putrescine as a probe in brain tumors (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-12
    Description: The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volkow, N -- Goldman, S S -- Flamm, E S -- Cravioto, H -- Wolf, A P -- Brodie, J D -- NS15638/NS/NINDS NIH HHS/ -- S07RR05399/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):673-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain Neoplasms/*radionuclide imaging ; Glioma/radionuclide imaging ; Kinetics ; Neoplasm Transplantation ; *Putrescine/metabolism ; Rats ; Tomography, Emission-Computed
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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