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  • Mice  (79)
  • United States  (68)
  • Cells, Cultured  (42)
  • Genes
  • American Association for the Advancement of Science (AAAS)  (187)
  • Annual Reviews
  • 1980-1984  (187)
  • 1955-1959
  • 1930-1934
  • 1981  (187)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (187)
  • Annual Reviews
  • Springer  (2)
Years
  • 1980-1984  (187)
  • 1955-1959
  • 1930-1934
Year
  • 1
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    Testosterone: a major determinant of extragenital sexual dimorphism (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: Sexual dimorphism in selected extragenital tissues is described with emphasis on the molecular basis of the differences. Testosterone rather than 5 alpha-dihydrotestosterone appears to be the major intracellular androgen in organs other than skin and reproductive tract, but other steroid metabolites and their receptors are required to produce the diverse tissue differences observed in males and females. There is also evidence that multiple hormones from several endocrine glands are required to act in concert with androgens to produce and maintain their effects. Although many of the consequences of sexual dimorphism, such as body size and strength, have been evident for centuries, other differences between males and females such as disease incidence, response to drugs and toxins, and the metabolism and assimilation of dietary constituents have only recently been discovered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bardin, C W -- Catterall, J F -- HD-13541/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1285-94.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010603" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen-Insensitivity Syndrome/metabolism ; Androgens/metabolism/physiology ; Animals ; Erythropoiesis ; Estradiol/physiology ; Humans ; Kidney/metabolism ; Liver/metabolism ; Male ; Mice ; Muscles/metabolism ; Progestins/physiology ; Proteins/secretion ; Rats ; Receptors, Androgen/metabolism ; *Sex Differentiation ; Testosterone/metabolism/*physiology ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    GABA analogues activate channels of different duration on cultured mouse spinal neurons (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-17
    Description: Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Mathers, D A -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects ; Ion Channels/*drug effects ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects ; Receptors, Cell Surface/metabolism ; Receptors, GABA-A ; Spinal Nerves/*drug effects ; Structure-Activity Relationship ; Time Factors ; gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    National Science Foundation budgets: fiscal years 1982, 1982, and beyond (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Branscomb, L M -- New York, N.Y. -- Science. 1981 May 1;212(4494):514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209546" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior ; Budgets ; Cognition ; Economics ; Engineering/economics ; Forecasting ; *Government Agencies ; Research Support as Topic/*economics ; Social Sciences/economics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Fraud and the structure of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1981 Apr 10;212(4491):137-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209527" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Crime ; *Fraud ; National Institutes of Health (U.S.) ; *Research ; Social Control, Formal ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The synthetic peptide NH2-Tyr-Pro-Phe-Pro-CONH2 (morphiceptin), which is the amide of a fragment of the milk protein beta-casein, has morphinelike activities and is highly specific for morphine (mu) receptors but not for enkephalin (delta) receptors. It is as active as morphine in the guinea pig ileum but much less active in the mouse and rat vas deferens. The discovery of this specific morphine receptor ligand substantiates the hypothesis of multiple opiate receptors. The ligand, which may be of physiological significance since a very similar, or identical, activity can be detected in enzymatic digests of beta-casein, may prove useful for further investigation of the functions of opiate receptor subtypes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chang, K J -- Lillian, A -- Hazum, E -- Cuatrecasas, P -- Chang, J K -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Caseins/pharmacology ; Dihydromorphine/metabolism ; Endorphins/*pharmacology ; Enkephalins/metabolism ; Guanosine Triphosphate/pharmacology ; Guinea Pigs ; Ileum/drug effects ; Male ; Mice ; Naloxone/metabolism ; Rats ; Receptors, Opioid/*drug effects ; Sodium/pharmacology ; Vas Deferens/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cancer researchers defend NCI against congressional attacks (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):117.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244625" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; National Institutes of Health (U.S.)/*organization & administration ; *Neoplasms ; *Research ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    The major histocompatibility complex in man (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dausset, J -- New York, N.Y. -- Science. 1981 Sep 25;213(4515):1469-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792704" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/genetics ; Forecasting ; Genes ; Genes, MHC Class II ; Genetic Linkage ; HLA Antigens/genetics ; Humans ; Immune Tolerance ; Immunity, Cellular ; *Major Histocompatibility Complex ; Polymorphism, Genetic ; Transplantation Immunology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Melatonin: identification of sites of antigonadal action in mouse brain (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: Long-term implants releasing a small quantity of melatonin (45 nanograms per day) were used to determine the brain sites of the hormone's antigonadal action in a photoperiodic species, the white-footed mouse (Peromyscus leucopus). Implants in the medial preoptic and supra- and retrochiasmatic areas elicited completed gonadal regression after 7 weeks. Implants in other brain regions had little effect on the animals' reproductive state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glass, J D -- Lynch, G R -- NS-15503/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genitalia, Female/drug effects/*pathology ; Hypothalamus/*drug effects ; Light ; Melatonin/*pharmacology ; Mice ; Periodicity ; Preoptic Area/drug effects ; Supraoptic Nucleus/drug effects
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  • 9
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    Renin and angiotensin: the complete system within the neuroblastoma x glioma cell (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, M C -- Zimmerman, E A -- Slater, E E -- HL-21247/HL/NHLBI NIH HHS/ -- HL-24105/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272392" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin I/*analysis ; Angiotensin II/*analysis ; Angiotensins/*analysis ; Animals ; Cell Line ; Cricetinae ; Glioma/*metabolism ; Hybrid Cells/*metabolism ; Mice ; Neuroblastoma/*metabolism ; Peptidyl-Dipeptidase A/metabolism ; Radioimmunoassay ; Rats ; Renin/*metabolism
    Print ISSN: 0036-8075
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  • 10
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    Phenytoin-induced teratogenesis: a mouse model (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finnell, R H -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):483-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455686" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Epilepsy/drug therapy ; Female ; Mice ; Mice, Neurologic Mutants/physiology ; Phenytoin/*adverse effects ; *Teratogens
    Print ISSN: 0036-8075
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  • 11
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    Science and the universities (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: The university system in Canada, as well as its method of funding, was built on the expectation of growth. It is now necessary to consider what effect the expected decline in enrollment may have on the ability of the university system to serve national needs. Neither the government nor the universities have had any experience that would fit them for carrying out effectively, humanly, and economically the kind of contraction that may be required, while still maintaining the quality of education. Such an adjustment is going to require the best efforts of the universities and the two senior levels of government working in concert, as well as the support of the public. Parallels are drawn with the situation in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fortier, C -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1065-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268413" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; *Science ; United States ; Universities/manpower/*trends
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Malignant potential of murine stromal cells after transplantation of human tumors into nude mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: Human malignant cancer tumors grafted into nude mice produce tumors containing both human cancer cells and the host's stromal cells. After short-term propagation of these tumors in vitro, the murine mesenchymal cells appear transformed and are tumorigenic in nude mice. However, established human cancer cell lines fail to similarly after adjacent murine stromal cells when used to produce tumors in nude mice. These experiments suggest that cancer cells may recruit normal cells to become malignant, qualifying the view of the clonal (unicellular) origin of cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldenberg, D M -- Pavia, R A -- 1R01 CA17198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209521" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/pathology ; Animals ; Cell Line ; Cells, Cultured ; Colonic Neoplasms/pathology ; Fibrosarcoma/*etiology ; Humans ; Karyotyping ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Transplantation ; Neoplasms, Experimental/*etiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Radiosensitivity of human cells in vitro (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furcinitti, P S -- Todd, P -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209518" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Survival/*radiation effects ; Cells, Cultured ; Dose-Response Relationship, Radiation ; HeLa Cells/radiation effects ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Voltage clamp studies in macrophages from mouse spleen cultures (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: Voltage clamp studies of macrophages from cultures of mouse spleen macrophages produced N-shaped steady-state current-voltage curves containing a region of negative slope resistance. Some macrophages exhibit two stable states of membrane potential, having current-voltage relationships that cross the voltage axis at three points. Outward currents that turn on at voltages of +15 millivolts or greater were noted in several cells. The addition of barium chloride to the bathing medium abolished the negative slope resistance and reduced the inward currents in response to hyperpolarizing voltage steps. These data provide direct evidence that macrophages exhibit at least tow different voltage-dependent conductances and demonstrate that voltage clamp techniques can be useful in studying the membrane properties of leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallin, E K -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):458-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/pharmacology ; Cell Membrane/physiology ; Cells, Cultured ; Electric Conductivity ; Macrophages/*physiology ; Membrane Potentials ; Mice ; Spleen/cytology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Multiple opiate receptors: alcohol selectively inhibits binding to delta receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-23
    Description: The addition of ethanol or other aliphatic alcohols to rat brain membranes strongly inhibits binding of enkephalins at concentrations at which little inhibition of opiate alkaloids is seen. Inhibition is reversible, and potency increases with chain length of the alcohol. The results suggest that delta receptors are considerably more sensitive to alcohols than mu receptors. This is the first demonstration of selective inhibition of one of the postulated classes of opiate receptors by a reagent that is not a ligand for the receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hiller, J M -- Angel, L M -- Simon, E J -- DA-00017/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 23;214(4519):468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270788" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohols/*pharmacology ; Animals ; Brain/metabolism ; Cells, Cultured ; In Vitro Techniques ; Neuroblastoma/metabolism ; Rats ; Receptors, Opioid/classification/*drug effects/metabolism ; Structure-Activity Relationship
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  • 16
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    Do jumping genes make evolutionary leaps? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):634-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256261" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; DNA/*genetics ; Genes ; Recombination, Genetic
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  • 17
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    Library of medicine versus private enterprise (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1125-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015508" target="_blank"〉PubMed〈/a〉
    Keywords: Industry ; *Information Services ; *Medlars ; *National Library of Medicine (U.S.) ; United States
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  • 18
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    Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenzo, J A -- Raisz, L G -- AM 07290/AM/NIADDK NIH HHS/ -- AM 18063/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1157-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785885" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/*pharmacology ; Bone Resorption/*drug effects ; Bone and Bones/drug effects/*metabolism ; Calcimycin/*pharmacology ; Calcium/metabolism ; Calcium Radioisotopes ; Cells, Cultured ; DNA/*biosynthesis ; DNA Replication/*drug effects ; Ethers/pharmacology ; Fetus ; Ionomycin ; Ionophores/pharmacology ; Kinetics ; Mice ; Parathyroid Hormone/pharmacology
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  • 19
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    The AF64a-treated mouse: possible model for central cholinergic hypofunction (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: A loss in the number of functional, sodium ion-dependent, high-affinity choline transport sites was observed in the cortex and hippocampus of mice given an intracerebroventricular injection of 65 nanomoles of AF64A (ethylcholine mustard aziridinium ion) 3 days earlier. Such an effect was not observed in the striatum. This effect of AF64A represents a long-term neurochemical deficit at cholinergic nerve terminals in some brain regions which can lead to a persistent deficiency in central cholinergic transmission. The AF64A-treated animal may thus be a model for certain psychiatric or neurological disorders that appear to involve central cholinergic hypofunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mantione, C R -- Fisher, A -- Hanin, I -- MH 26320/MH/NIMH NIH HHS/ -- MH/AG 34893/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):579-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6894649" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aziridines/*pharmacology ; Azirines/*pharmacology ; Biological Transport/drug effects ; Brain/drug effects/*metabolism ; Cerebral Cortex/metabolism ; Choline/*analogs & derivatives/*metabolism/pharmacology ; Corpus Striatum/metabolism ; Hippocampus/metabolism ; Kinetics ; Mice ; Sodium/pharmacology ; Synaptosomes/drug effects/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    FDA sees no radiation risk in VDT screens (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1120-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7248044" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Display ; Humans ; Radiation Injuries/*etiology ; Risk ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, T F -- Kowalchyk, J A -- AM 25861/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267695" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division/*drug effects ; Cell Line ; Cricetinae ; Cyclic AMP/*pharmacology ; DNA/biosynthesis ; Growth Inhibitors/*pharmacology ; Mice ; Phosphodiesterase Inhibitors/pharmacology ; Structure-Activity Relationship
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    More progress on gene transfer (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):996-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6943678" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *DNA, Recombinant ; *Genetic Engineering ; Mice ; Recombination, Genetic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Viral epitopes and monoclonal antibodies: isolation of blocking antibodies that inhibit virus neutralization (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: The inability of pathogenic animal viruses to be completely neutralized by antibodies can lead to chronic viral infections in which infectious virus persists even in the presence of excess neutralizing antibody. A mechanism that results in this nonneutralized fraction of virus was defined by the topographical relationships of viral epitopes identified with monoclonal antibodies wherein monoclonal antibodies bind to virus and sterically block the binding of neutralizing antibodies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Massey, R J -- Schochetman, G -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies ; Antibodies, Monoclonal ; *Antigen-Antibody Complex ; Antigens, Viral ; Clone Cells ; Kirsten murine sarcoma virus/*immunology ; Mammary Tumor Virus, Mouse/*immunology ; Mice ; Sarcoma Viruses, Murine/*immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsukura, N -- Kawachi, T -- Morino, K -- Ohgaki, H -- Sugimura, T -- Takayama, S -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):346-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbolines/*pharmacology ; *Carcinogens ; Drug Evaluation, Preclinical ; Female ; Indoles/*pharmacology ; Male ; Mice ; Mice, Inbred Strains ; Mutagens/*pharmacology ; Neoplasms, Experimental/chemically induced ; Sex Factors
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    A new wave of antibiotics builds (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302591" target="_blank"〉PubMed〈/a〉
    Keywords: *Cephalosporins/therapeutic use ; Humans ; Research ; Structure-Activity Relationship ; United States
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    FDA approves hepatitis B vaccine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302582" target="_blank"〉PubMed〈/a〉
    Keywords: Hepatitis B/*prevention & control ; Hepatitis B Surface Antigens/*standards ; Humans ; United States ; United States Food and Drug Administration ; *Vaccines
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  • 27
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    Copper deficiency suppresses the immune response of mice (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: Mice fed a purified diet low in copper display anemia, hypoceruloplasminemia, depressed concentrations of liver copper, and elevated concentrations of liver iron. An impaired humoral-mediated immune response (decreased numbers of antibody-producing cells) is observed in mice with severe as well as marginal copper deficiency. The magnitude of this impairment is highly correlated with the degree of functional copper deficiency (hypoceruloplasminemia).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prohaska, J R -- Lukasewycz, O A -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244654" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Formation/*drug effects ; Body Weight/drug effects ; Ceruloplasmin/metabolism ; Copper/*deficiency/pharmacology ; Female ; Hemoglobins/metabolism ; Iron/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred Strains ; Organ Size/drug effects ; Sex Factors ; Spleen/drug effects
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    E. Margaret Burbidge, president-elect (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rubin, V C -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):915-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008193" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/history ; History, 20th Century ; Societies, Scientific/*history ; United States
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  • 29
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    Changes in DNA during meiosis in a repair-deficient mutant (rad 52) of yeast (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-01
    Description: The kinetic patterns of DNA synthesis in wild-type (RAD+) and rad 52 mutants of yeast, which exhibit high levels of synchrony during meiosis, are comparable. However, RAD 52 mutants accumulate single-strand breaks in parental DNA during the DNA synthesis period. Thus, the product of the RAD 52 gene has a role in meiotic DNA metabolism, as well as in the repair of DNA damage during mitotic growth. The observed breaks may be unresolved recombination intermediates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Resnick, M A -- Kasimos, J N -- Game, J C -- Braun, R J -- Roth, R M -- 5 R01 GM17317-11/GM/NIGMS NIH HHS/ -- S07-RR07027/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1981 May 1;212(4494):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010606" target="_blank"〉PubMed〈/a〉
    Keywords: *DNA Repair ; DNA, Fungal/genetics ; DNA, Single-Stranded/genetics ; Genes ; *Meiosis ; Molecular Weight ; Mutation ; *Recombination, Genetic ; Saccharomyces cerevisiae/*genetics
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    The federal government's role in basic research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmitt, H -- New York, N.Y. -- Science. 1981 Jan 16;211(4479):226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444463" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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    Diameter of the cell-to-cell junctional membrane channels as probed with neutral molecules (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules-neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwarzmann, G -- Wiegandt, H -- Rose, B -- Zimmerman, A -- Ben-Haim, D -- Loewenstein, W R -- CA 14464/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244653" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chironomidae ; Fluorescent Dyes ; Glycopeptides/*metabolism ; Intercellular Junctions/*ultrastructure ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligosaccharides/*metabolism ; Protein Conformation ; Salivary Glands/*ultrastructure ; Species Specificity
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    Myelination of central nervous system axons in tissue culture by transplanted oligodendrocytes (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: Unmyelinated mouse cerebellar cerebellar cultures in which oligodendrocyte differentiation had been suppressed by exposure to cytosine arabinoside developed axonal myelin after superimposition of kainic acid-treated cerebellar explants devoid of myelin-receptive axons. The latter explants contained differentiated oligodendrocytes. The operation of a diffusible myelin-stimulating factor was ruled out by the failure of myelination in cytosine arabinoside-exposed explants not in direct contact with oligodendrocyte-containing transplants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seil, F -- Blank, N K -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Axons/drug effects/*physiology ; Cerebellum/drug effects/*physiology ; Collagen ; Cytarabine/pharmacology ; Kainic Acid/pharmacology ; Mice ; Myelin Sheath/drug effects/*physiology ; Neuroglia/*transplantation ; Oligodendroglia/*transplantation ; Organ Culture Techniques
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    Aspartame approved despite risks (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):986-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268411" target="_blank"〉PubMed〈/a〉
    Keywords: Aspartame/*standards ; Dipeptides/*standards ; United States ; United States Food and Drug Administration
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    FDA plans action on sodium in foods (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1373.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233225" target="_blank"〉PubMed〈/a〉
    Keywords: *Food Handling ; Humans ; *Sodium ; United States ; *United States Food and Drug Administration
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    OSHA shifts direction on health standards (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1482-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233234" target="_blank"〉PubMed〈/a〉
    Keywords: *Federal Government ; *Government Agencies ; *Government Regulation ; *Health Policy ; Humans ; Occupational Diseases/*prevention & control ; United States
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    Cancer institute passes first test in senate (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1122.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233205" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; Humans ; National Institutes of Health (U.S.) ; *Neoplasms ; Politics ; *Research Support as Topic ; United States
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  • 37
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    Studies in histocompatibility (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snell, G D -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):172-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017931" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Viral/genetics ; Antigens, Viral, Tumor ; Female ; Genetic Linkage ; Genotype ; H-2 Antigens/genetics ; Heterozygote ; *Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/genetics/*immunology ; Pedigree ; Rats ; Species Specificity
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  • 38
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    Compensation for victims of vaccines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):906-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466364" target="_blank"〉PubMed〈/a〉
    Keywords: *Compensation and Redress ; Costs and Cost Analysis ; Disclosure ; Drug Industry/economics/*standards ; *Federal Government ; Humans ; Insurance ; *Jurisprudence ; Mandatory Programs ; Risk ; Risk Assessment ; United States ; Vaccines/*adverse effects ; Voluntary Programs
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  • 39
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    Cancer institute's drug program reproved (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):887-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302567" target="_blank"〉PubMed〈/a〉
    Keywords: Disclosure ; Drug Evaluation/*standards ; Federal Government ; *Government Regulation ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms/*drug therapy ; Politics ; Risk Assessment ; *Therapeutic Human Experimentation ; United States ; United States Food and Drug Administration
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    Reagan reforms create upheaval at NIOSH (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):166-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280688" target="_blank"〉PubMed〈/a〉
    Keywords: National Institutes of Health (U.S.)/*organization & administration ; Occupational Medicine/*standards ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    Institute, keratotomists don't see eye to eye (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):423-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244640" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; Myopia/*surgery ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    Immunization of Baboons with Schistosoma mansoni Cercariae attenuated by gamma irradiation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: Studies on the efficacy of a vaccine against schistosomiasis in young baboons (Papio anubis) disclosed that immunization with Schistosoma mansoni cercariae attenuated by gamma irradiation induced significant protection against subsequent infection with normal, viable S. mansoni cercariae. Such immunization resulted in reduced worm burdens (70 percent) and egg excretion rates (82 percent). These results support immunization as a potential method for schistosomiasis control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stek M, F r -- Minard, P -- Dean, D A -- Hall, J E -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1518-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233238" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Immunization ; Mice ; Mice, Inbred Strains ; Papio ; Schistosoma mansoni/immunology/*radiation effects ; Schistosomiasis/prevention & control
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  • 43
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    Hatch batters NCI with straus case (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015513" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Federal Government ; *Government Regulation ; History, 20th Century ; Humans ; *National Institutes of Health (U.S.) ; Neoplasms ; Politics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 44
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    Amniocentesis: be prepared (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233217" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; *Amniocentesis ; Congenital Abnormalities/diagnosis ; Federal Government ; Female ; Humans ; Legislation, Medical ; Pregnancy ; United States
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  • 45
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    Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-31
    Description: Erythrocytes infected with the late stages of the human malarial parasite Plasmodium falciparum became attached to a subpopulation of cultured human endothelial cells by knoblike protrusions on the surface of the infected erythrocytes. Infected erythrocytes did not bind to cultured fibroblasts; uninfected erythrocytes did not bind to either endothelial cells or fibroblasts. The results suggest a specific receptor-ligand interaction between endothelial cells and a component, components, in the knobs of the infected erythrocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Udeinya, I J -- Schmidt, J A -- Aikawa, M -- Miller, L H -- Green, I -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017935" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus ; Cells, Cultured ; Endothelium/microbiology ; Erythrocytes/*microbiology/ultrastructure ; Female ; Humans ; Microscopy, Electron ; Plasmodium falciparum/*pathogenicity ; Pregnancy ; Umbilical Veins
    Print ISSN: 0036-8075
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  • 46
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    Gold pipettes make for tight lips (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1368.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233223" target="_blank"〉PubMed〈/a〉
    Keywords: Ethics ; *Industry ; *Information Dissemination ; *Research ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
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    Gene therapy pioneer draws Mikadoesque rap (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1253.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6940246" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Recombinant/*therapeutic use ; Ethics Committees, Research ; Federal Government ; *Genetic Engineering ; *Government Regulation ; Humans ; *Legislation, Medical ; National Institutes of Health (U.S.) ; United States
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  • 48
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    Gene therapy caught in more entanglements (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259731" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *DNA, Recombinant ; *Ethics Committees, Research ; *Ethics, Medical ; Federal Government ; Female ; *Genetic Engineering/history ; Genetic Vectors ; Globins/genetics ; Government Regulation ; History, 20th Century ; Humans ; Informed Consent ; Israel ; Plasmids ; Thalassemia/*therapy ; United States
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  • 49
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    Medical journal draws lancet on rival (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):561.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455694" target="_blank"〉PubMed〈/a〉
    Keywords: Information Services ; *Periodicals as Topic ; Publishing ; Research ; United States
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  • 50
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    Mouse pox threat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: A News and Comment Briefing ("OSHA backs away from strict lab rules," 28 Nov. 1980, p. 992) incorrectly quoted a National Research Council report on safe handling of laboratory chemicals as saying, "For most laboratory environments, ... regular monitoring of the airborne concentrations of a variety of different toxic materials is both unjustified and unjust." The report actually said it was "unjustified and impractical."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallace, G D -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):438.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6256854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Laboratory/*microbiology ; Disease Outbreaks/*veterinary ; Ectromelia virus ; Ectromelia, Infectious/*epidemiology ; Mice ; Mice, Inbred Strains ; Poxviridae Infections/*epidemiology ; Rodent Diseases/epidemiology ; United States
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  • 51
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    Carter transmits an interim budget (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walsh, J -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455684" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets/*legislation & jurisprudence ; Financial Management/*legislation & jurisprudence ; Government Agencies ; National Institutes of Health (U.S.) ; *Research Support as Topic ; United States
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  • 52
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    Hormonal requirements for growth of arterial smooth muscle cells in vitro: and endocrine approach to atherosclerosis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinstein, R -- Stemerman, M B -- Maciag, T -- AM 07026/AM/NIADDK NIH HHS/ -- HL 06197/HL/NHLBI NIH HHS/ -- HL 07374/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 15;212(4496):818-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7013068" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Abdominal/cytology ; Cell Division/drug effects ; Cells, Cultured ; Culture Media ; Growth Substances/pharmacology ; Hormones/*pharmacology ; Insulin/pharmacology ; Muscle, Smooth, Vascular/*cytology ; Rats ; Transferrin/pharmacology
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  • 53
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    Intestinal M cells: a pathway for entry of reovirus into the host (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: Thirty minutes after inoculation of reovirus type 1 into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 hour, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. These findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolf, J L -- Rubin, D H -- Finberg, R -- Kauffman, R S -- Sharpe, A H -- Trier, J S -- Fields, B N -- AI 13178/AI/NIAID NIH HHS/ -- AM 07121/AM/NIADDK NIH HHS/ -- AM 17537/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):471-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Suckling/microbiology ; Endocytosis ; Extracellular Space/microbiology ; Intestinal Mucosa/cytology/*microbiology ; Mice ; Peyer's Patches/microbiology ; Receptors, Virus/metabolism ; Reoviridae/*physiology ; Reoviridae Infections/*pathology
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  • 54
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    Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-03
    Description: The low activity of liver neuraminidase that is characteristic of mouse strain SM/J is inherited as a single gene on chromosome 17, near the major histocompatibility complex. This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and most other strains. Previously described variations in the posttranslational processing of acid phosphatase, alpha-mannosidase, arylsulfatase-B, and alpha-glucosidase are attributed to pleiotropic effects of this gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Womack, J E -- Yan, D L -- Potier, M -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):63-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209520" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Chromosome Mapping ; Female ; H-2 Antigens/genetics ; Hydrolases/*metabolism ; Liver/enzymology ; Major Histocompatibility Complex ; Male ; Mice ; Mice, Inbred Strains/*genetics/metabolism ; Neuraminidase/*genetics ; Protein Precursors/*metabolism ; Recombination, Genetic ; Sialic Acids/metabolism
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    Two classes of single-stranded regions in DNA from sea urchin embryos (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-06
    Description: Native DNA from sea urchin embryos contains single-stranded regions (gaps) of up to 3000 nucleotides. The longer gaps (more than 1400 nucleotides) are nonrandomly distributed and are rich in histone gene sequences, other moderately repetitive sequences, and polypyrimidines. The shorter gaps are associated with DNA replication. A method for isolation of the two classes of single-stranded DNA pieces is reported.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wortzman, M S -- Baker, R F -- New York, N.Y. -- Science. 1981 Feb 6;211(4482):588-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455698" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; *DNA Replication ; DNA, Single-Stranded/*analysis/genetics ; Genes ; Histones/*genetics ; Recombination, Genetic ; Sea Urchins/*genetics
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  • 56
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    Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: The ability of murine tumor cells to metastasize spontaneously from subcutaneous sites is positively correlated with the total sialic acid content of the cells in culture, the degree to which the sialic acid is exposed on the tumor cell surface, and, most strongly, with the degree of sialylation of galactosyl and N-acetylgalactosaminyl residues in cell surface glycoconjugates. These findings suggest that sialic acid on the cell surface may play a role in tumor cell metastasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yogeeswaran, G -- Salk, P L -- CA19312-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1514-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233237" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/*physiology ; Cell Transformation, Neoplastic ; Cell Transformation, Viral ; Mice ; *Neoplasm Metastasis ; Neoplasms, Experimental/*physiopathology ; Sialic Acids/*analysis
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  • 57
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    Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement. Most groups of mice treated with monoclonal immunoglobulin G3 antibodies did not develop tumors, but the tumor that appeared in a treated animal had a much lower amount of the GgOS3Cer than the cells used for inoculation. Thus, passive immunization either prevented growth of the lymphoma or caused selection of a variant with a lower quantity of the antigen GgOS3Cer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, W W Jr -- Hakomori, S I -- CA27746/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):487-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455688" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm ; Antigens, Surface ; Clone Cells/immunology ; Glycolipids/*immunology ; Hybrid Cells/immunology ; Immunization, Passive ; Immunoglobulin G/administration & dosage ; Immunoglobulin M/administration & dosage ; Immunotherapy ; Lymphoma/immunology/*therapy ; Mice ; Neoplasms, Experimental/therapy
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  • 58
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    Abortion and the limitations of science (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zack, B G -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):291.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244615" target="_blank"〉PubMed〈/a〉
    Keywords: *Abortion, Spontaneous ; *Beginning of Human Life ; *Embryo, Mammalian ; Female ; Humans ; *Jurisprudence ; *Life ; *Personhood ; Pregnancy ; United States
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  • 59
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    Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-19
    Description: The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrett, J C -- Wong, A -- McLachlan, J A -- New York, N.Y. -- Science. 1981 Jun 19;212(4501):1402-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzo(a)pyrene ; Benzopyrenes ; Carcinogens ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Cricetinae ; Diethylstilbestrol/*pharmacology ; Embryo, Mammalian ; Genes/*drug effects ; Mesocricetus ; *Mutation
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    Effectiveness of psychotherapy (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bordin, E S -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):394-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244638" target="_blank"〉PubMed〈/a〉
    Keywords: Evaluation Studies as Topic ; Humans ; National Institutes of Health (U.S.) ; *Psychotherapy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    AAAS officers, staff, committees, and representatives for 1981 (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-02-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Feb 27;211(4485):925-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7008194" target="_blank"〉PubMed〈/a〉
    Keywords: *Directories as Topic ; *Societies, Scientific ; United States
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    Love Canal (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Jan 2;211(4477):8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6893760" target="_blank"〉PubMed〈/a〉
    Keywords: New York ; State Health Planning and Development Agencies ; United States ; Water Pollutants/*adverse effects ; Water Pollutants, Chemical/*adverse effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Differentiation of murine bone marrow stem cells in vitro: long-term growth promoted by a lymphocyte-derived mediator (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-02
    Description: In attempts to induce differentiation of lymphoid cells from hematopoietic stem cells in vitro, the effects of allogeneic effect factor on the growth of murine bone marrow cultures were studied. Allogeneic effect factor is a soluble mediator derived from mixed secondary murine leukocyte cultures. For several weeks it supported the growth of bone marrow cultures, as indicated by the maintenance of stem cell activity, cellular proliferation, and heterogeneity. Another lymphokine, T cell growth factor, did not, Pre-T lymphocytes could be detected in these cultures for several weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altman, A -- Gilmartin, T D -- Katz, D H -- CA-25803/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 2;211(4477):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6934621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Cells ; Cell Adhesion ; Cell Communication ; Cell Differentiation/*drug effects ; Colony-Forming Units Assay ; Glycoproteins/*pharmacology ; Hematopoietic Stem Cells/*cytology ; Histocompatibility Antigens Class II ; Lymph Nodes/cytology ; Lymphokines/*pharmacology ; Mice ; Mitogens
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
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    Myeloma neuropathy: passive transfer from man to mouse (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: Mice were injected daily, for up to 10 weeks, with purified monoclonal immunoglobulin G from patients with myelomatous polyneuropathy or benign gammopathy. The animals developed a demyelinating polyneuropathy with slowed nerve conduction velocities. The putative antinerve factor may be an antibody since injection of Fab fragments from the monoclonal immunoglobulin G produced a similar demyelination. This provides evidence of a circulating factor in the serum of myeloma patients with polyneuropathy that reproduces typical features of the human disease on passive transfer. This disorder is thus distinguished from other neuropathies that occur as remote effects of malignant disease but have no identified pathogenic factors associated with them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besinger, U A -- Toyka, K V -- Anzil, A P -- Fateh-Mognadam, A -- Rouscher, R -- Heininger, K -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):1027-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268405" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/*immunology ; Demyelinating Diseases/*etiology/immunology/physiopathology ; Female ; Humans ; Immunization, Passive ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; Immunoglobulin G ; Mice ; Multiple Myeloma/*complications ; Neural Conduction
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Reversal diabetes by islet transplantation: vulnerability of the established allograft (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowen, K M -- Prowse, S J -- Lafferty, K J -- AM28126-01/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 11;213(4513):1261-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6791285" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/cytology ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/*therapy ; *Graft Rejection ; Islets of Langerhans/immunology ; *Islets of Langerhans Transplantation ; Mice ; Organ Culture Techniques ; Transplantation, Homologous
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Team research: responsibility at the top (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):114-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244624" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; *Ethics ; Humans ; Moral Obligations ; *Research ; *Social Responsibility ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Research in EPA: A congressional point of view (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: From lessons learned in several years of overseeing the research programs of the Environmental Protection Agency, the authors conclude that the agency should give more support to the accumulation of the scientific "intellectual capital" needed for managing the environment in the long term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, G E Jr -- Byerly, R Jr -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466395" target="_blank"〉PubMed〈/a〉
    Keywords: Environment ; *Government Agencies ; *Research ; Research Support as Topic ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Age at menarche: a misunderstanding (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bullough, V L -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):365-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017929" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Age Factors ; Child ; England ; Female ; *History of Medicine ; History, 19th Century ; History, 20th Century ; History, Medieval ; Humans ; *Menstruation ; United States
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  • 69
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    Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-13
    Description: 3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-L1 fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-L1 fibroblasts to fat cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiang, P K -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1164-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466386" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*cytology ; Animals ; Carnitine/pharmacology ; Cell Differentiation/*drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Fibroblasts/cytology ; Methylation ; Mice ; Ribonucleosides/*pharmacology ; Tubercidin/*pharmacology
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    Behavioral effects of lead and Toxocara canis in mice (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-04
    Description: Adult mice were administered the common parasite Toxocara canis or lead or both. The parasite clearly altered mouse performance on tests of exploration, activity, learning, and motor coordination; behavioral effects in mice receiving lead alone were less general. Consequence of Toxocara administration appeared attenuated in animals receiving both agents. Parasite larvae were found in the central nervous system in all infected mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dolinsky, Z S -- Burright, R G -- Donovick, P J -- Glickman, L T -- Babish, J -- Summers, B -- Cypess, R H -- 08-K4AI00301A-03/AI/NIAID NIH HHS/ -- 08R1AI1478A-03/AI/NIAID NIH HHS/ -- 5S07RR0749-04/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1142-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268424" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascariasis/*complications ; Behavior, Animal/*physiology ; Brain/parasitology ; Disease Models, Animal ; Lead Poisoning/*complications/physiopathology ; Male ; Mice ; Toxocariasis/*complications/physiopathology
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    Fredrickson resigns for NIH (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culliton, B J -- New York, N.Y. -- Science. 1981 Jul 3;213(4503):111-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7017930" target="_blank"〉PubMed〈/a〉
    Keywords: History, 20th Century ; National Institutes of Health (U.S.)/*organization & administration ; United States
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    Delta9-tetrahydrocannabinol increase plasma testosterone concentrations in mice (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-31
    Description: Oral administration of delta 9-tetrahydrocannabinol had a biphasic effect on plasma testosterone concentrations in male mice, causing rapid sustained increases at low doses and subsequent decreases at higher doses. In hypophysectomized and intact mice receiving gonadotropins (human chorionic gonadotropin), treatment with delta 9-tetrahydrocannabinol maintained higher plasma testosterone concentrations. Thus, this cannabinoid may interact with gonadotropin and directly influence testicular steroidogenesis in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalterio, S -- Bartke, A -- Mayfield, D -- 1R01 DA 02/DA/NIDA NIH HHS/ -- P 30 HD 10202/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):581-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/pharmacology ; Dronabinol/*analogs & derivatives/pharmacology ; Hypophysectomy ; Kinetics ; Luteinizing Hormone/*blood ; Male ; Mice ; Testosterone/*blood
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    A conjugate of alpha-amanitin and monoclonal immunoglobulin G to Thy 1.2 antigen is selectively toxic to T lymphoma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-18
    Description: A covalent conjugate of an alpha-amanitin azo derivative and a monoclonal immunoglobulin G to the Thy 1.2 antigen on murine T lymphocytes was synthesized. The conjugate was 375- to 750-fold more inhibitory to murine T lymphoma S49.1 cells than the unconjugated derivative. At 0.7 X 10(-7) to 1.5 X 10(-7) M and at 4 X 10(-7) M amanitin equivalents, the conjugate inhibited protein synthesis in S49.1 cells by 50 percent and 80 to 96 percent, respectively. At these concentrations, mutant Thy l-deficient S49 cells and other murine lymphoma lacking Thy l altogether or carrying Thy 1.1 antigens were unaffected. This result demonstrated the potential for targeting amanitin to specific cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M T -- Preston, J F 3rd -- R01 CA 19043/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 18;213(4514):1385-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6115471" target="_blank"〉PubMed〈/a〉
    Keywords: Amanitins/*administration & dosage ; Amino Acids/metabolism ; Animals ; Antibodies/administration & dosage ; Antibodies, Monoclonal ; Antigens, Surface/*immunology ; Antigens, Thy-1 ; Cells, Cultured ; Clone Cells/immunology ; Hybrid Cells/immunology ; Immunoglobulin G/*administration & dosage ; Lymphoma/*drug therapy ; Membrane Proteins/*immunology ; Mice ; Neoplasms, Experimental/drug therapy ; T-Lymphocytes/drug effects
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    Ethanol reveals novel mercury detoxification step in tissues (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-09-04
    Description: Volatile mercury was produced de novo by mouse tissue homogenates that contained mercuric ions. Ethanol stimulated the release of tissue mercury into the vapor phase, and the mechanism appears to be an inhibition of reoxidation of volatile mercury. Components responsible for mercury volatilization are heat-labile. The highest volatilizing activity in the liver is associated with the soluble fraction obtained after centrifugation at 105,000g.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dunn, J D -- Clarkson, T W -- Magos, L -- 01248/PHS HHS/ -- ES 01247/ES/NIEHS NIH HHS/ -- GM 07141/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1123-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268418" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Compartmentation ; Cell-Free System ; Cysteine ; Ethanol/*pharmacology ; Gases ; *Inactivation, Metabolic ; Kidney/*metabolism ; Liver/*metabolism ; Mercury/*metabolism ; Mice ; Oxidation-Reduction
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    Lateral diffusion of surface molecules in animal cells and tissues (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-21
    Description: When bound to cell surfaces, certain lectins such as concanavalin A induce a drop in the average diffusion coefficients (D) of a number of cell surface molecules. To find whether such anchorage modulation occurs naturally, D of surface antigens on different cell and tissue types were measured by fluorescence photobleaching recovery. Values for cells of the same tissue origin under different conditions of growth and association - in tissues, in small aggregates, and as isolated cells - varied by less than twofold when polyspecific monovalent antibodies to cell surface antigens were used, a range much less than the sixfold decrease in D observed after lectin-induced anchorage modulation. Thus, if reversible modulation of the diffusion rate is used naturally as a means of cell signaling, it must involve only a few kinds of surface receptors not detected by the antibodies used in this study. In certain tissues, however, a significant proportion of cells showed no apparent receptor mobility. This "all or none" modulation of lateral diffusion may reflect relatively long-lasting alterations in the states of a single cell type or differentiation among the cells of the particular tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gall, W E -- Edelman, G M -- AI-09273/AI/NIAID NIH HHS/ -- AI-11378/AI/NIAID NIH HHS/ -- AM-04256/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):903-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7196087" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Surface/physiology ; Cell Adhesion ; Cell Division ; Cells, Cultured ; Chick Embryo ; Cytoskeleton/physiology ; Diffusion ; *Membrane Fluidity ; Mice
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    Interferon action: RNA cleavage pattern of a (2'-5')oligoadenylate--dependent endonuclease (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floyd-Smith, G -- Slattery, E -- Lengyel, P -- AI-12320/AI/NIAID NIH HHS/ -- CA-16038/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 May 29;212(4498):1030-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6165080" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/*pharmacology ; Animals ; Carcinoma, Ehrlich Tumor/enzymology ; *Endoribonucleases ; HeLa Cells/enzymology ; Humans ; Interferons/*pharmacology ; Mice ; Oligonucleotides/*pharmacology ; Oligoribonucleotides/*pharmacology ; Rna ; Ribonucleases/*metabolism ; Ribonucleotides/analysis ; Substrate Specificity
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    Parasitism and behavioral dominance among male mice (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-07-24
    Description: Infestations by the nematode Heligmosomoides polygyrus can prevent adult male mice from becoming behaviorally dominant. The effect is dose-dependent and is more likely to influence the development of dominance than to disrupt existing dominance relationships. Doses capable of exerting this effect are not lethal and do not affect weight.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeland, W J -- R03 MH 32090/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):461-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244643" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Dominance-Subordination ; Larva ; Male ; Mice ; Nematoda ; Nematode Infections/*psychology ; *Social Dominance
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    Brain acetylcholine synthesis declines with senescence (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-08-07
    Description: The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 +/- 4 per cent in 10-month-old mice and by 58 +/- 9 percent in 30-month-old mice compared with mice 3 months old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10- and 30-month-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, G E -- Peterson, C -- Jenden, D J -- MH17691/MH/NIMH NIH HHS/ -- MS15649/PHS HHS/ -- NS16997/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Aug 7;213(4508):674-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256270" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*biosynthesis ; *Aging ; Animals ; Behavior, Animal/physiology ; Brain/*metabolism ; Choline/metabolism ; Glucose/metabolism ; Lactates/metabolism ; Mice
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  • 79
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    Phase locking, period-doubling bifurcations, and irregular dynamics in periodically stimulated cardiac cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: The spontaneous rhythmic activity of aggregates of embryonic chick heart cells was perturbed by the injection of single current pulses and periodic trains of current pulses. The regular and irregular dynamics produced by periodic stimulation were predicted theoretically from a mathematical analysis of the response to single pulses. Period-doubling bifurcations, in which the period of a regular oscillation doubles, were predicted theoretically and observed experimentally.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guevara, M R -- Glass, L -- Shrier, A -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1350-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cells, Cultured ; Chick Embryo ; Electric Stimulation ; Heart/*physiology ; In Vitro Techniques ; Membrane Potentials ; Models, Biological ; *Myocardial Contraction ; Periodicity
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  • 80
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    Mechanisms of gonadal differentiation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-20
    Description: Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haseltine, F P -- Ohno, S -- 5R01 HD 12289-02/HD/NICHD NIH HHS/ -- R0I AD 00042/AD/ADAMHA HHS/ -- New York, N.Y. -- Science. 1981 Mar 20;211(4488):1272-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7010601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Disorders of Sex Development ; Embryonic Induction ; Female ; Fertility ; Freemartinism/genetics ; Germ Cells/physiology ; H-Y Antigen/genetics/*physiology ; Humans ; Male ; Mammals/genetics ; Mice ; Ovary/embryology ; Rats ; Sex Chromosomes ; *Sex Determination Analysis ; *Sex Differentiation ; Testis/embryology/physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
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    Hatch on NCI hearings (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hatch, O G -- New York, N.Y. -- Science. 1981 Jul 24;213(4506):392.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244636" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *National Institutes of Health (U.S.) ; *Neoplasms ; *Research Support as Topic ; United States
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  • 82
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    Epidermal growth factors enhances viral transformation of granulosa cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-10
    Description: Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, J -- Auersperg, N -- New York, N.Y. -- Science. 1981 Jul 10;213(4504):218-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6264597" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Viral/*drug effects ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Female ; Granulosa Cells/*cytology/drug effects ; Kirsten murine sarcoma virus/drug effects/*genetics ; Peptides/*pharmacology ; Rats ; Sarcoma Viruses, Murine/*genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 83
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    Hayes intends modest reforms at FDA. Interview by R. Jeffery Smith (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, A Jr -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):984-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268410" target="_blank"〉PubMed〈/a〉
    Keywords: Pharmaceutical Preparations/standards ; United States ; *United States Food and Drug Administration
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  • 84
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    Somatomedin B: mitogenic activity derived from contaminant epidermal growth factor (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-04
    Description: The mitogenic effect of somatomedin B on human cultured glial cells was neutralized by the addition of antibodies to mouse epidermal growth factor. Somatomedin B contained epidermal growth factor--like activity, competing for binding to the epidermal growth factor receptor. It is concluded that contaminating epidermal growth factor may explain the entire mitogenic activity of somatomedin B.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heldin, C H -- Wasteson, A -- Fryklund, L -- Westermark, B -- New York, N.Y. -- Science. 1981 Sep 4;213(4512):1122-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6973821" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Epidermal Growth Factor/*pharmacology ; Growth Substances/*pharmacology ; Humans ; Neuroglia ; Peptides/*pharmacology ; Somatomedins/*pharmacology ; Structure-Activity Relationship
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  • 85
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    Somatic cell hybrids from frog lymphocytes and mouse myeloma cells (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: Stable somatic cell hybrids were obtained by fusing Xenopus lymphocytes with mouse myeloma cells. These hybrids contained one to four Xenopus chromosomes and expressed Xenopus gene products, one of which was a lymphocyte membrane protein of 85,000 daltons precipitated by a monoclonal antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hengartner, H -- Du Pasquier, L -- New York, N.Y. -- Science. 1981 May 29;212(4498):1034-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6785884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Antibodies, Monoclonal ; Cell Line ; Clone Cells ; Genes ; Hybrid Cells/*physiology ; Lymphocytes/*physiology ; Membrane Proteins/biosynthesis ; Mice ; Molecular Weight ; Neoplasms, Experimental/physiopathology ; Plasmacytoma/*physiopathology ; Xenopus
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  • 86
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    Clinical trial of psychotherapies is under way (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1981 Apr 24;212(4493):432-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7209541" target="_blank"〉PubMed〈/a〉
    Keywords: Cognition ; Depression/*therapy ; Humans ; Interpersonal Relations ; National Institutes of Health (U.S.) ; *Psychotherapy/methods ; Research Support as Topic ; United States
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  • 87
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    Cousins' account of self-cure rapped (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7029711" target="_blank"〉PubMed〈/a〉
    Keywords: Ascorbic Acid/therapeutic use ; *Famous Persons ; History, 20th Century ; *Holistic Health/history ; Humans ; Male ; Spondylitis, Ankylosing/*therapy ; United States
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  • 88
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    Police seize primates at NIH-funded lab (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):32-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6792707" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Laboratory ; *Haplorhini ; National Institutes of Health (U.S.) ; Research/standards ; United States
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  • 89
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    Lamarck will not lie down (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-07-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):316-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Immune Tolerance ; *Immunogenetics ; Mice ; Periodicals as Topic ; Quality Control ; *Research Design
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  • 90
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    The Hmong: dying of culture shock? (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshal, E -- New York, N.Y. -- Science. 1981 May 29;212(4498):1008.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233195" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; *Cultural Characteristics ; *Culture ; Female ; Humans ; Laos/ethnology ; Male ; Middle Aged ; *Mortality ; Refugees/*psychology ; Stress, Physiological ; United States
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  • 91
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    Seeds of change in embryonic development (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewin, R -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):42-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280679" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Evolution ; Embryology/*trends ; Genes ; Selection, Genetic
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  • 92
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    Hemin lyses malaria parasites (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orjih, A U -- Banyal, H S -- Chevli, R -- Fitch, C D -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):667-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7027441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chloroquine/*pharmacology ; Drug Interactions ; Drug Resistance ; Heme/*analogs & derivatives ; Hemin/*pharmacology ; Mice ; Plasmodium berghei/*drug effects
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  • 93
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    The prolactin gene is located on chromosome 6 in humans (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: The gene for prolactin has been located on chromosome 6 in humans. DNA fragments of 4.8 and 4.0 kilobases containing prolactin gene sequences were identified in human genomic DNA, whereas DNA fragments of 7.4, 3.6, and 3.3 kilobases containing prolactin gene sequences were found in mouse cells. In somatic cell hybrids of human and mouse cells the 7.4-, 3.6-, and 3.3-kilobase mouse fragments were always present, whereas the 4.8- and 4.0-kilobase human fragments were only present when human chromosome 6 was also present. We conclude that the prolactin gene resides on chromosome 6, a different location from those of the genes for the related hormones chorionic somatomammotropin and growth hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Owerbach, D -- Rutter, W J -- Cooke, N E -- Martial, J A -- Shows, T B -- AM 21344/AM/NIADDK NIH HHS/ -- GM 20454/GM/NIGMS NIH HHS/ -- HD 05196/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 May 15;212(4496):815-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221563" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosomes, Human, 6-12 and X ; Genes ; Genetic Linkage ; Growth Hormone/genetics ; Humans ; Hybrid Cells/physiology ; Mice ; Placental Lactogen/genetics ; Prolactin/*genetics
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  • 94
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    Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Methionine enkephalin release was evoked by depolarization of slices from rat striatum with potassium. In the presence of 0.1 microM thiorphan [(N(R,S)-3-mercapto-2-benzylpropionyl)glycine], a potent inhibitor of enkephalin dipeptidyl carboxypeptidase (enkephalinase), the recovery of the pentapeptide in the incubation medium was increased by about 100 percent. A similar effect was observed with the dipeptide phenylalanylalanine, a selective although less potent enkephalinase inhibitor. Inhibition of other known enkephalin-hydrolyzing enzymes--aminopeptidase by 0.1 mM puromycin or angiotensin-converting enzyme by 1 microM captopril--did not significantly enhance the recovery of released methionine enkephalin. These data indicate that enkephalinase is critically involved in the inactivation of the endogenous opioid peptide released from striatal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patey, G -- De La Baume, S -- Schwartz, J C -- Gros, C -- Roques, B -- Fournie-Zaluski, M C -- Soroca-Lucas, E -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7015510" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids, Sulfur/*pharmacology ; Animals ; Corpus Striatum/drug effects/*metabolism ; Endorphins/*secretion ; Enkephalin, Methionine ; Enkephalins/antagonists & inhibitors/*secretion ; Mice ; Neprilysin ; Potassium/pharmacology ; *Protease Inhibitors/*pharmacology ; Rats ; Thiorphan ; Tiopronin/analogs & derivatives/*pharmacology
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  • 95
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    Sensory and motor functions of spinal cord substance P (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-18
    Description: Low doses of D-Pro2-D-Phe7-D-Trp9-substance P, as specific substance P antagonist, depressed the scratching and biting behaviors elicited by intrathecal injections of substance P, and cutaneous application of algesic substances. Higher antagonist doses caused hindlimb paralysis. This suggests that substance P is a neurotransmitter for primary nociceptor afferents and may also have an important function in motor control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piercey, M F -- Schroeder, L A -- Folkers, K -- Xu, J C -- Horig, J -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6171882" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capsaicin/pharmacology ; Mice ; Motor Activity/drug effects ; Pain/*physiopathology ; Receptors, Cell Surface/drug effects ; Receptors, Neurokinin-1 ; Receptors, Neurotransmitter/drug effects ; Skin/drug effects ; Spinal Cord/*physiology ; Substance P/analogs & derivatives/antagonists & ; inhibitors/pharmacology/*physiology
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  • 96
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    Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. Spike generation was blocked by MnCl2. In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCann, F V -- Pettengill, O S -- Cole, J J -- Russell, J A -- Sorenson, G D -- CA 25845/CA/NCI NIH HHS/ -- DA 23108/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6262914" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Calcium/pharmacology ; Carcinoma, Small Cell/*physiopathology ; Cells, Cultured ; Electric Conductivity ; Humans ; Lung Neoplasms/*physiopathology ; Manganese/pharmacology ; Membrane Potentials/drug effects
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  • 97
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    Psychoneuroendocrine influences on immunocompetence and neoplasia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-05
    Description: Emotional, psychosocial, or anxiety-stimulated stress produces increased plasma concentrations of adrenal corticoids and other hormones though well-known neuroendocrine pathways. A direct consequence of these increased corticoid concentrations is injury to elements of the immunological apparatus, which may leve the subject vulnerable to the action of latent oncogenic viruses, newly transformed cancer cells, or other incipient pathological processes that are normally held in check by an intact immunological apparatus. This article describes studies that examine the adverse effects of increased plasma concentrations of adrenal corticoids on the thymus and thymus-dependent T cells, inasmuch as these elements constitute a major defense system against various neoplastic processes and other pathologies. The studies demonstrate that anxiety-stress can be quantitatively induced and the consequences measured through specific biochemical and cellular parameters, providing that authentic quiescent baselines of these conditions are obtained in the experimental animals by the use of low-stress protective housing and handling techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- CA 12188/CA/NCI NIH HHS/ -- CA 16308/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1100-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233204" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Corticosterone/blood ; Female ; Handling (Psychology) ; Humans ; *Immunocompetence ; Leukocytes/physiology ; Mice ; Mice, Inbred Strains ; Neoplasms/*etiology/physiopathology/psychology ; Neoplasms, Experimental/*physiopathology ; Species Specificity ; Stress, Physiological/*complications ; Stress, Psychological/*complications ; Tumor Virus Infections/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 98
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    Fc and C3b receptors on pulmonary endothelial cells: induction by injury (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Receptors for the activated third component of complement and for the Fc portion of immunoglobulin G are not expressed by apparently normal bovine pulmonary endothelial cells, but are expressed when the cells are exposed to white cell lysates or are infected with influenza or cytomegalovirus. The unmasking of these latent receptors may contribute to the pulmonary inflammatory response characteristic of, for example, anaphylaxis and to those lung diseases characterized by the deposition of immune complexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ryan, U S -- Schultz, D R -- Ruan, J W -- HL 21568/HL/NHLBI NIH HHS/ -- HL 22087/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):557-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270789" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle ; Cells, Cultured ; Complement C3b/metabolism ; Cytomegalovirus Infections/physiopathology ; Endothelium/metabolism ; Orthomyxoviridae Infections/physiopathology ; Pulmonary Artery/*cytology ; Receptors, Complement/*metabolism ; Receptors, Fc/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 99
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    Risk and benefit in environmental law (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: Judicial review establishes whether the mandate of Congress is observed by an agency's rule-making mechanisms for setting environmental standards or other regulations. Central issues in risk assessment now include whether a risk is significant, what the burden of proof for significance is, how to resolve the tension between the effort to reduce hazardous exposures and the goal of efficient regulation, and precisely how and in what detail the costs of regulation must be measured. Under current regulatory statutes, there are several paradigms for balancing costs and benefits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ricci, P F -- Molton, L S -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1096-100.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302580" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinogens ; *Environment ; Environmental Pollution ; Government Agencies ; Humans ; *Legislation as Topic ; Risk ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 100
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    Indirect costs (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1981 Sep 11;213(4513):1198, 1200, 1202-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268427" target="_blank"〉PubMed〈/a〉
    Keywords: *Research Support as Topic ; United States ; Universities/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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