Publication Date:
1981-08-28
Description:
Mice were injected daily, for up to 10 weeks, with purified monoclonal immunoglobulin G from patients with myelomatous polyneuropathy or benign gammopathy. The animals developed a demyelinating polyneuropathy with slowed nerve conduction velocities. The putative antinerve factor may be an antibody since injection of Fab fragments from the monoclonal immunoglobulin G produced a similar demyelination. This provides evidence of a circulating factor in the serum of myeloma patients with polyneuropathy that reproduces typical features of the human disease on passive transfer. This disorder is thus distinguished from other neuropathies that occur as remote effects of malignant disease but have no identified pathogenic factors associated with them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Besinger, U A -- Toyka, K V -- Anzil, A P -- Fateh-Mognadam, A -- Rouscher, R -- Heininger, K -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):1027-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268405" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoimmune Diseases/*immunology
;
Demyelinating Diseases/*etiology/immunology/physiopathology
;
Female
;
Humans
;
Immunization, Passive
;
Immunoglobulin Fab Fragments
;
Immunoglobulin Fc Fragments
;
Immunoglobulin G
;
Mice
;
Multiple Myeloma/*complications
;
Neural Conduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink