Publication Date:
1981-07-31
Description:
Mice fed a purified diet low in copper display anemia, hypoceruloplasminemia, depressed concentrations of liver copper, and elevated concentrations of liver iron. An impaired humoral-mediated immune response (decreased numbers of antibody-producing cells) is observed in mice with severe as well as marginal copper deficiency. The magnitude of this impairment is highly correlated with the degree of functional copper deficiency (hypoceruloplasminemia).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prohaska, J R -- Lukasewycz, O A -- New York, N.Y. -- Science. 1981 Jul 31;213(4507):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244654" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibody Formation/*drug effects
;
Body Weight/drug effects
;
Ceruloplasmin/metabolism
;
Copper/*deficiency/pharmacology
;
Female
;
Hemoglobins/metabolism
;
Iron/metabolism
;
Liver/metabolism
;
Male
;
Mice
;
Mice, Inbred Strains
;
Organ Size/drug effects
;
Sex Factors
;
Spleen/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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