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  • Mice  (167)
  • Cell Line  (55)
  • American Association for the Advancement of Science (AAAS)  (199)
  • 1995-1999
  • 1980-1984  (128)
  • 1975-1979  (71)
  • 1925-1929
  • 1983  (128)
  • 1978  (71)
  • 1976
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  • American Association for the Advancement of Science (AAAS)  (199)
  • Springer  (3)
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  • 1995-1999
  • 1980-1984  (128)
  • 1975-1979  (71)
  • 1925-1929
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  • 1
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    Cholinergic vesicles: ability to empty and refill independently of cytoplasmic acetylcholine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-06
    Beschreibung: Incubation of minced mouse-forebrain tissues in lithium Krebs solution reduces the acetylcholine content of the vesicular fraction 70 percent without altering that of the cytoplasmic fraction. Depleted vesicular-bound acetylcholine can be restored with newly synthesized acetylcholine (formed from extracellular choline) independently of the cytoplasmic pool. Depletion of vesicular-bound acetylcholine does not facilitate the movement of preformed extracellular acetylcholine into vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carrol, P T -- Nelson, S H -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):85-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Toxicology, University of Rhode Island, Kingston, RI 02881, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569492" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/*metabolism ; Animals ; Cholinesterase Inhibitors/pharmacology ; Cytoplasm/*metabolism ; Cytoplasmic Vesicles/drug effects/*metabolism ; Lithium Compounds/pharmacology ; Male ; Mice ; Paraoxon/pharmacology ; Prosencephalon/drug effects/*metabolism/ultrastructure
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-11-17
    Beschreibung: C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciment, G -- de Vellis, J -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):765-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213832" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenylyl Cyclases/*metabolism ; *Cell Communication ; Cell Line ; Cholera Toxin/pharmacology ; Cyclic AMP/metabolism ; Enzyme Activation/drug effects ; Membrane Proteins/metabolism ; Protein Binding ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-10
    Beschreibung: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Estrogen-binding sites in endothelial cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-01
    Beschreibung: The cytosol extracted from a vascular endothelial cell line binds [3H]estradiol with high affinity and a high degree of specificity. In contrast, in experiments performed with cytosol labeled in the intact cell, progesterone and, to a smaller extent, testosterone gave an apparent inhibition of estradiol binding. These data support the concept that ovarian hormones may influence the role of the endothelium in various physiological and pathophysiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colburn, P -- Buonassisi, V -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):817-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684408" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aorta/*metabolism ; Cell Line ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Endothelium/metabolism ; Estradiol/metabolism ; Progesterone/pharmacology ; Receptors, Estrogen/drug effects/*metabolism ; Testosterone/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Rejection of male skin grafts by splenectomized female mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-04-21
    Beschreibung: Female mice of the C3H strain normally do not reject skin grafts from males of the same strain; however, 40 percent of splenectomized C3H female mice completely rejected C3H male skin grafts applied 2 weeks later. All splenectomized females showed at least transitory signs of graft rejection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coons, T A -- Goldberg, E H -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345443" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; *Graft Rejection ; *Histocompatibility Antigens ; Immunosuppression ; Male ; Mice ; Mice, Inbred C3H/immunology ; Skin Transplantation ; Spleen/*immunology ; Transplantation, Homologous ; Y Chromosome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Dual actions of substance P on nociception: possible role of endogenous opioids (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-24
    Beschreibung: Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frederickson, R C -- Burgis, V -- Harrell, C E -- Edwards, J D -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1359-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204012" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Baclofen/pharmacology ; Dose-Response Relationship, Drug ; Endorphins/*pharmacology ; Enkephalins/antagonists & inhibitors/*pharmacology ; Mice ; Naloxone/pharmacology ; Nociceptors/*drug effects ; Receptors, Opioid/*drug effects ; Structure-Activity Relationship ; Substance P/analogs & derivatives/antagonists & inhibitors/*pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Nicotinamide adenine dinucleotide splitting enzyme: a characteristic of the mouse macrophage (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-12-22
    Beschreibung: Murine macrophages are endowed with nicotinamide adenine dinucleotide splitting activity that is markedly higher than that of other cells, tissues, or organs of the mouse. This enzyme therefore can be used as a biochemical marker for distinguishing macrophages from other cells of the lymphoreticular system and from polymorphonuclear leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Artman, M -- Seeley, R J -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214853" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Ascitic Fluid/enzymology ; B-Lymphocytes/enzymology ; Blood Platelets/enzymology ; Bone Marrow/enzymology ; Humans ; Lymph Nodes/enzymology ; Macrophages/*enzymology ; Mice ; Monocytes/enzymology ; NAD+ Nucleosidase/*metabolism ; Neutrophils/enzymology ; Spleen/enzymology ; T-Lymphocytes/enzymology ; Tissue Distribution
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Trisodium phosphonoformate, a new antiviral compound (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-01
    Beschreibung: Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helgstrand, E -- Eriksson, B -- Johansson, N G -- Lannero, B -- Larsson, A -- Misiorny, A -- Noren, J O -- Sjoberg, B -- Stenberg, K -- Stening, G -- Stridh, S -- Oberg, B -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):819-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210500" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antiviral Agents/therapeutic use/toxicity ; Cell Line ; DNA-Directed RNA Polymerases/*antagonists & inhibitors ; Formates/pharmacology/toxicity ; Guinea Pigs ; Herpesviridae Infections/drug therapy ; *Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds/*pharmacology/toxicity ; Phosphonoacetic Acid/pharmacology ; Simplexvirus/enzymology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Biological activity of some oxygenated sterols (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-11
    Beschreibung: A group of oxygenated sterols has been identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a structural component or as a precursor of other steroid products. The use of oxygenated sterols to block sterol synthesis in cultured cells provides new information regarding the role of sterol in cell membrane structure and function. For example, de novo sterol synthesis is required for DNA synthesis and cell division by some cultured cells. Studies with cultured cells, and with rats and mice in vivo, suggest that oxygenated sterols could be of value in the treatment of several important human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kandutsch, A A -- Chen, H W -- Heiniger, H J -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663671" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/metabolism ; Cell Division ; Cell Line ; Cholesterol/biosynthesis/*metabolism ; Feedback ; Humans ; Hydroxycholesterols/*metabolism ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Intestines/metabolism ; Ketosteroids/*metabolism ; Liver/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-22
    Beschreibung: Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mondal, S -- Brankow, D W -- Heidelberger, C -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1141-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684434" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Carcinogens ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; Cocarcinogenesis ; Embryo, Mammalian ; Methylcholanthrene ; Mice ; Mice, Inbred C3H ; Saccharin/*pharmacology ; Tetradecanoylphorbol Acetate
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Identification of a C-glucuronide of delta6- tetrahydrocannabinol as a mouse liver conjugate in vivo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-06-23
    Beschreibung: Delta 6-Tetrahydrocannabinol-C-4-glucuronide was found in the livers of mice that had been administered delta 6-tetrahydrocannabinol. Thus, C-glucuronidation of a compound that contains a free hydroxyl group has been demonstrated in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levy, S -- Yagen, B -- Mechoulam, R -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663618" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dronabinol/*analogs & derivatives/metabolism ; Glucuronates/metabolism ; Liver/*metabolism ; Mice
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-13
    Beschreibung: The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piletz, J E -- Ganschow, R E -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619449" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; *Lactation ; Mice ; Mice, Inbred C57BL/*genetics ; Milk/*metabolism ; Pregnancy ; Zinc/blood/*deficiency/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Growth inhibition of transformed cells with succinylated concanavalin A (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-01
    Beschreibung: Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mannino, R J -- Ballmer, K -- Burger, M M -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):824-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210502" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Adhesion/drug effects ; Cell Cycle/*drug effects ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Concanavalin A/*analogs & derivatives/pharmacology ; Simian virus 40 ; Succinates
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Generation of new mouse sarcoma viruses in cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-01
    Beschreibung: Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapp, U R -- Todaro, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):821-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210501" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; *Cell Transformation, Neoplastic ; Cell Transformation, Viral ; *Genes, Viral ; Mice ; Retroviridae/genetics/*pathogenicity ; Sarcoma Viruses, Murine/genetics/pathogenicity ; Sarcoma, Experimental/*microbiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Acoustic microscopy: a new window to the world of the small (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1110-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684431" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acoustics/*instrumentation ; Animals ; Blood Cells/ultrastructure ; Mice ; Microscopy/*instrumentation/methods ; Muscles/ultrastructure ; Myocardium/ultrastructure
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Prenatal exposure to prednisone in humans and animals retards intrauterine growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-10-27
    Beschreibung: Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reinisch, J M -- Simon, N G -- Karow, W G -- Gandelman, R -- New York, N.Y. -- Science. 1978 Oct 27;202(4366):436-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705336" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Birth Weight/*drug effects ; Female ; Fetus/*drug effects ; Humans ; *Infant, Low Birth Weight ; Infant, Newborn ; Male ; Mice ; Prednisone/*adverse effects ; Pregnancy/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-31
    Beschreibung: delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415367" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Depression, Chemical ; Dose-Response Relationship, Drug ; Dronabinol/*pharmacology ; Female ; Haplorhini ; Humans ; Male ; Mice ; Motor Activity/drug effects ; Rats ; Saimiri ; Territoriality
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-18
    Beschreibung: In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhard, R E -- Dirgo, J A -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/209541" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenine Nucleotides/metabolism ; Aminophylline/*pharmacology/therapeutic use ; Animals ; Anoxia/physiopathology ; Apnea/drug therapy ; Brain/drug effects/*metabolism ; Cheyne-Stokes Respiration/drug therapy ; Cyclic AMP/metabolism ; Energy Metabolism/*drug effects ; Glucose/metabolism ; Glucosephosphates/metabolism ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Mice
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-10-06
    Beschreibung: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Effect of oxygen pressure during culture on survival of mouse thyroid allografts (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-06-02
    Beschreibung: A marked increase in the percentage of mouse thyroids that retained function 20 days after transplantation across a major histocompatibility barrier and the percentage that lacked generalized infiltration was observed when the grafts received hyperbaric oxygen during a 4-day culture period. Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmage, D W -- Dart, G A -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1066-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653355" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood ; Culture Media ; *Graft Survival/drug effects ; Hydrocortisone/pharmacology ; *Hyperbaric Oxygenation ; Mice ; Organ Culture Techniques/*methods ; Thyroid Gland/*transplantation ; Transplantation, Homologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Homeostasis of the antibody response: immunoregulation by NK cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-11
    Beschreibung: When injected into mice, the synthetic double-stranded polynucleotide poly(inosinic) X poly(cytidylic) acid induces high natural killer (NK) cell activity within 4 to 12 hours. Induction of NK activity in mice immunized 2 or 3 days previously, or the addition of NK cells to cultures immunized in vitro 2 or 3 days previously, promotes early termination of the ongoing primary immunoglobulin M antibody response. A target for NK cells is a population of accessory cells that has interacted with antigen and is necessary for sustaining the antibody response. The inference is strong that NK cells induced normally by immunization also terminate the usual antibody response in vivo by elimination of antigen-exposed accessory cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abruzzo, L V -- Rowley, D A -- 5-T32-CA-09267/CA/NCI NIH HHS/ -- R01-10242/PHS HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):581-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6685343" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibody Formation ; Antibody-Producing Cells/immunology ; Cells, Cultured ; Homeostasis ; Killer Cells, Natural/*immunology/radiation effects ; Lymphocyte Cooperation ; Lymphocytes/*immunology ; Mice ; Poly I-C/immunology ; Spleen/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Primary murine bone marrow cultures support continuous growth of infectious human trypanosomes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-22
    Beschreibung: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 23
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    Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-18
    Beschreibung: Cholesterol-loaded macrophages secrete cholesterol and apolipoprotein E. The current studies show that this secretion occurs by two independent pathways. In the absence of serum, the cells secrete apolipoprotein E, but not cholesterol. In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E. After secretion, apolipoprotein E and cholesterol associate with high-density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor-mediated endocytosis. We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in "reverse cholesterol transport."〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basu, S K -- Goldstein, J L -- Brown, M S -- HL 20948/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):871-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823554" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Apolipoproteins/*secretion ; Cholesterol/*secretion ; Lipoproteins, HDL/metabolism ; Macrophages/*metabolism ; Mice ; Monensin/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    A polypeptide secreted by transformed cells that modulates human plasminogen activator production (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: A diffusible factor produced and secreted by malignant murine cells was capable of inducing plasminogen activator production by normal diploid human fibroblasts. The factor's ability to induce plasminogen activator was insensitive to treatment with nucleases, but its activity was destroyed by digestion with proteases. It is proposed that such a factor would play a role in malignancy if it would recruit normal cells that were adjacent to transformed cells to produce plasminogen activator which could result in tumor-promoted proteolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davies, R L -- Rifkin, D B -- Tepper, R -- Miller, A -- Kucherlapati, R -- CA-16239/CA/NCI NIH HHS/ -- CA-35171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6682999" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cricetinae ; Fibroblasts/drug effects/metabolism ; Humans ; Hybrid Cells/metabolism ; Melanoma/metabolism ; Mice ; Neoplasms, Experimental/*metabolism/secretion ; Peptides/pharmacology/*secretion ; Plasminogen Activators/*biosynthesis ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Scientist sues over genetically impure mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, J L -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):625-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603019" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Laboratory ; Jurisprudence ; Mice ; *Mice, Inbred BALB C ; Rats ; Rats, Inbred Lew ; Rats, Inbred Strains ; Research ; United States ; Wisconsin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 26
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    Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-27
    Beschreibung: Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodman, R R -- Kuhar, M J -- Hester, L -- Snyder, S H -- DA-00266/DA/NIDA NIH HHS/ -- MH-18501/MH/NIMH NIH HHS/ -- NS-16375/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 May 27;220(4600):967-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302841" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine/*physiology ; Animals ; Autoradiography ; Axons/*physiology ; Cerebellum/physiology ; Corpus Striatum/physiology ; Hippocampus/physiology ; Mice ; Mice, Neurologic Mutants ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*physiology ; Receptors, Purinergic ; Retinal Ganglion Cells/physiology ; Synaptic Membranes/physiology ; Thalamus/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    High efficiency DNA-mediated transformation of primate cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: An important question concerning the mechanism of somatic mutation of immunoglobulin variable (V) genes is whether it involves all of the numerous V genes in a differentiated B cell, independent of location, or if it is restricted to a particular chromosomal site. Comparison of the sequence of two alleles of a given V gene shows that the mutations are limited to the rearranged V gene, while the same V gene on the other chromosome has not undergone mutation. This indicates that a V gene sequence alone is not sufficient for somatic mutation to take place. The mutation is therefore restricted to the rearranged V gene and consequently does not occur before rearrangement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorski, J -- Rollini, P -- Mach, B -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1179-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857243" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Binding Sites, Antibody/*genetics ; Chromosomes/physiology ; DNA/genetics ; *Genes ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulins/genetics ; Lymphocytes/metabolism ; Mice ; *Mutation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    Isolation of lamellar bodies from neonatal mouse epidermis by selective sequential filtration (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-02
    Beschreibung: Isolation of epidermal lamellar bodies has presented a challenge because pressures required to homogenize keratinocytes can destroy these organelles and because the lamellar body readily releases its contents during prolonged isolation procedures. In an attempt to isolate lamellar bodies, sheets of intact stratum corneum and stratum granulosum were obtained from neonatal mice with highly purified staphylococcal epidermolytic toxin, disrupted, and passed through a series of filters. The final filtrate was rich in intact lamellar bodies and contained variable amounts of ribosomes and other vesicular structures. Availability of a highly purified lamellar body preparation from postnatal epidermis should help to clarify the role of this organelle in epidermal function. The technique of selective, sequential filtration represents a new approach to cell fractionation that may have wide applications in cell biology and biochemistry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grayson, S -- Johnson-Winegar, A D -- Elias, P M -- AM 19098/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):962-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879194" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Fractionation/methods ; Epidermis/*ultrastructure ; Filtration ; Mice ; Microscopy, Electron
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haspel, M V -- Onodera, T -- Prabhakar, B S -- Horita, M -- Suzuki, H -- Notkins, A L -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301002" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/*immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology/*microbiology ; Endocrine Glands/*immunology ; Enzyme-Linked Immunosorbent Assay ; Growth Hormone/immunology ; Humans ; Hybridomas/immunology ; Mice ; Pituitary Gland, Anterior/immunology ; Rats ; Reoviridae Infections/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Contiguity to males in utero affects avoidance responding in adult female mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-22
    Beschreibung: Female mice that had been situated in utero between two female fetuses displayed higher levels of active avoidance responding in adult life than females that had been located between two male fetuses and males for whom uterine position was without effect. Uterine position, therefore, influences acquired as well as species-typical behaviors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hauser, H -- Gandelman, R -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):437-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836288" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Androgens/physiology ; Animals ; Avoidance Learning/*physiology ; Female ; Fetus/*physiology ; Male ; Mice ; Pregnancy ; Rats ; Sex Factors ; Uterus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3. The isolate with the largest IR3 fragment has approximately 170 more codons than the isolates with the smallest IR3 fragment; it encodes an EBNA which is approximately 17,000 daltons larger than the smallest EBNA. The EBV IR3 encodes part of a 2-kilobase exon of a latently infected cell messenger RNA which must be translated into a repetitive amino acid domain of EBNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hennessy, K -- Heller, M -- van Santen, V -- Kieff, E -- CA 17281/CA/NCI NIH HHS/ -- CA 19264/CA/NCI NIH HHS/ -- GM 07183/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1396-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304878" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, Viral/*genetics ; Base Sequence ; Cell Nucleus/immunology ; DNA, Viral/*genetics ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/*genetics/immunology ; Humans ; Mice ; RNA, Viral/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Radioactive labeling of antibody: a simple and efficient method (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: A simple and efficient method of covalently coupling the strong chelator diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G antibodies. After being coupled and labeled with indium-111, a monoclonal antibody to carcinoembryonic antigen retained its ability to bind to its antigen in vitro and in vivo. In nude mice with a human colorectal xenograft, 41 percent of the injected radioactivity became localized in each gram of xenograft at 24 hours compared with 9 percent for control antibody and 19 percent for radioiodinated antibody to carcinoembryonic antigen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hnatowich, D J -- Layne, W W -- Childs, R L -- Lanteigne, D -- Davis, M A -- Griffin, T W -- Doherty, P W -- 1 RO1 CA26968/CA/NCI NIH HHS/ -- 1 RO1 GM26780/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):613-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836304" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibodies ; Antibodies, Monoclonal/immunology ; Carcinoembryonic Antigen/immunology ; Chromatography, High Pressure Liquid ; Humans ; Immunoglobulin G/immunology ; Isotope Labeling/*methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Transplantation ; Pentetic Acid
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 34
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    Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magrath, I -- Erikson, J -- Whang-Peng, J -- Sieverts, H -- Armstrong, G -- Benjamin, D -- Triche, T -- Alabaster, O -- Croce, C M -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1094-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316501" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/complications ; Antigens, Viral/analysis ; Burkitt Lymphoma/complications/*genetics ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/analysis ; Homosexuality ; Humans ; Immunoglobulin Light Chains/*biosynthesis ; Immunoglobulin kappa-Chains/*biosynthesis ; Male ; Oncogenes
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Synthesizing the opioid peptides (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):395-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836282" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aplysia/physiology ; Endorphins/*biosynthesis/genetics ; Humans ; Mice ; Nervous System Physiological Phenomena ; Pituitary Hormones, Anterior/biosynthesis/genetics ; Pro-Opiomelanocortin ; Protein Precursors/biosynthesis/genetics ; RNA, Messenger/metabolism ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Suppressing autoimmunity in mice (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):843-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6576470" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal ; Autoimmune Diseases/*therapy ; Histocompatibility Antigens Class II/immunology ; Immune Tolerance ; Isoantibodies ; Mice ; Myasthenia Gravis/therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Selective modification of glutathione metabolism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: Glutathione, a tripeptide thiol found in virtually all cells, functions in metabolism, transport, and cellular protection. It participates in the reduction of disulfides and other molecules, and conjugates with compounds of exogenous and endogenous origin. It protects cells against the destructive effects of reactive oxygen intermediates and free radicals. Modifications of glutathione metabolism may be achieved by administration of selective enzyme inhibitors, and also by giving compounds that increase glutathione synthesis. Such effects are useful in chemotherapy and radiation therapy and in protecting cells against the toxic effects of drugs, other foreign compounds, and oxygen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meister, A -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):472-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836290" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Transport ; Free Radicals ; Glutathione/analogs & derivatives/biosynthesis/*metabolism/physiology ; Glutathione Disulfide ; Glutathione Synthase/deficiency/metabolism ; Humans ; Leukemia L1210/metabolism ; Mice ; Oxidation-Reduction ; Peroxides/metabolism ; Pyroglutamate Hydrolase/metabolism ; Trypanosoma brucei brucei/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Drug-induced alterations of cytokeratin organization in cultured epithelial cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-04
    Beschreibung: The distribution of keratin intermediate filaments, previously considered static in organization and imperturbable by conventional drugs used to alter the structure and organization of the cytoskeleton, can be altered significantly by treatment with colchicine and cytochalasin D. The loss of microfilaments and microtubules converts the keratin cytoskeleton from a branching, even distribution to a series of starlike structures whose filaments are maintained by multiple membrane attachment sites. These findings provide a means for manipulating cytokeratin organization to investigate the role of keratins in cytoskeletal structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapp, L W -- O'Guin, W M -- Sawyer, R H -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186022" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Colchicine/*pharmacology ; Cytochalasin D ; Cytochalasins/*pharmacology ; Cytoskeleton/*drug effects ; Epithelium ; *Keratins ; Mice ; Microtubules/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Passive transfer of diabetes in the BB/W rat (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-13
    Beschreibung: Severe diabetes with insulitis was produced in young diabetes-prone BB/W rats by passive transfer of concanavalin A-treated spleen cells from BB/W animals with acute diabetes. Spleen cells alone or in combination with lymph node cells were active in transferring disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koevary, S -- Rossini, A -- Stoller, W -- Chick, W -- Williams, R M -- AM-25306/AM/NIADDK NIH HHS/ -- AM-30846/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):727-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836309" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Concanavalin A/pharmacology ; Diabetes Mellitus/etiology/*immunology ; Hyperglycemia/etiology/immunology ; Immunity, Cellular ; Mice ; Mice, Nude ; Rats ; Spleen/cytology/drug effects/transplantation ; Transplantation, Heterologous ; Transplantation, Homologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Genetically obese mice: resistance to metastasis of B16 melanoma and enhanced T-lymphocyte mitogenic responses (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: The metastasis of B16 melanoma cells differed significantly in obese (ob/ob) and lean (+/?) female mice of strain C57BL/6J. When the mice were inoculated subcutaneously with melanoma cells at 10 to 11 months of age, the primary tumor grew more slowly in obese than in lean littermates and the frequency of lung metastasis was greatly reduced. When the mice were injected with the cells at 4 to 7 months, the primary tumor grew at the same rate in obese and lean mice, but the obese mice again showed a significantly reduced frequency of lung metastasis. That this effect was related to an enhanced immunocompetence in obese mice was supported by the finding that splenic lymphocytes of ob/ob mice showed three times the proliferative response to the T-cell mitogen concanavalin A compared with the proliferative response of lean control mice. The ob/ob mouse may provide a model for the study of enhanced immunocompetence in obese individuals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thompson, C I -- Kreider, J W -- Black, P L -- Schmidt, T J -- Margules, D L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602379" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Immunity, Innate ; Lung Neoplasms/immunology ; Male ; Melanoma/*immunology ; Mice ; Mice, Inbred C57BL ; *Mice, Obese ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology ; Rats ; Receptors, Glucocorticoid/physiology ; T-Lymphocytes/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
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    Monoclonal antibodies reveal the structural basis of antibody diversity (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-18
    Beschreibung: Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the specificity and affinity of antibodies. Comparisons of families of monoclonal antibodies derived from a single germ line gene revealed the importance of somatic mutation in generating antibody diversity. Monoclonal antibodies that react with variable regions of other monoclonals allow the further dissection and modulation of the immune response. Finally, the continued somatic instability of immunoglobulin genes in cultured antibody-forming cells makes it possible to determine the rate of somatic mutation and to generate mutant monoclonal antibodies that may be more effective serological reagents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teillaud, J L -- Desaymard, C -- Giusti, A M -- Haseltine, B -- Pollock, R R -- Yelton, D E -- Zack, D J -- Scharff, M D -- 5T32GM7288/GM/NIGMS NIH HHS/ -- AI05231/AI/NIAID NIH HHS/ -- AI10702/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):721-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6356353" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/genetics/*immunology ; *Antibody Diversity ; Antibody Specificity ; Genes ; Hybridomas/immunology ; Immunoglobulin Idiotypes/immunology ; Immunoglobulin Variable Region/genetics ; Mice ; Mutation ; Protein Conformation ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 42
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    Bone cell differentiation and growth factors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-13
    Beschreibung: Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Urist, M R -- DeLange, R J -- Finerman, G A -- DEO2103-17/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1983 May 13;220(4598):680-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403986" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bone Development ; Bone Matrix/drug effects/physiology ; Bone Morphogenetic Proteins ; Bone Neoplasms/physiopathology ; Cattle ; Cell Differentiation ; DNA, Neoplasm/metabolism ; Dogs ; Growth Substances/*physiology ; Guinea Pigs ; Haplorhini ; Humans ; Insulin-Like Growth Factor II ; Mice ; *Osteogenesis ; Osteosarcoma/physiopathology ; Proteins/pharmacology/physiology ; Rabbits ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 43
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-03
    Beschreibung: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 44
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    Insulin receptor: evidence that it is a protein kinase (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-21
    Beschreibung: Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, R A -- Cassell, D J -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Cell Line ; Cells, Cultured ; Lymphocytes ; Molecular Weight ; Phosphoproteins/physiology ; Protein Kinases/*physiology ; Receptor, Insulin/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 45
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 46
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    Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-15
    Beschreibung: The structure of the messenger RNA (mRNA) encoding the precursor to mouse submaxillary epidermal growth factor (EGF) was determined from the sequence of a set of overlapping complementary DNA's (cDNA). The mRNA is unexpectedly large, about 4750 nucleotide bases, and predicts the sequence of preproEGF, a protein of 1217 amino acids (133,000 molecular weight). The EGF moiety (53 amino acids) is flanked by polypeptide segments of 976 and 188 amino acids at its amino and carboyxl termini, respectively. The amino terminal segment of the precursor contains seven peptides with sequences that are similar but not identical to EGF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scott, J -- Urdea, M -- Quiroga, M -- Sanchez-Pescador, R -- Fong, N -- Selby, M -- Rutter, W J -- Bell, G I -- 21344/PHS HHS/ -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):236-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602382" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; Epidermal Growth Factor/biosynthesis/*genetics ; Humans ; Male ; Mice ; RNA, Messenger/*genetics ; Submandibular Gland/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 47
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    Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates with the 55-kilodalton glycoprotein D of herpes simplex virus type 1 and neutralizes the infectivity of herpes simplex viruses 1 and 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seigneurin, J M -- Desgranges, C -- Seigneurin, D -- Paire, J -- Renversez, J C -- Jacquemont, B -- Micouin, C -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304881" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Antibodies, Monoclonal/*immunology ; B-Lymphocytes/immunology ; Bone Marrow/*immunology ; Bone Marrow Cells ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/immunology ; Simplexvirus/*immunology ; Viral Envelope Proteins ; Viral Proteins/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 48
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    Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Parenteral injection into mice of a toxic pentapeptide isolated from the cyanobacterium Microcystis aeruginosa induced thrombocytopenia, pulmonary thrombi, and hepatic congestion. The lethality of the toxin was unaffected by several anticoagulants. The acute liver damage that follows injection of the toxin has been attributed to direct action on liver cells but may be due to hypoxemia, heart failure, and shock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slatkin, D N -- Stoner, R D -- Adams, W H -- Kycia, J H -- Siegelman, H W -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1383-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6407109" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bacterial Toxins ; Blood Coagulation Tests ; Cyanobacteria/*metabolism ; Female ; Liver/pathology ; Lung/pathology ; Marine Toxins/*adverse effects ; Mice ; Organ Size/drug effects ; Platelet Count ; Pulmonary Embolism/*chemically induced/microbiology/pathology ; Thrombocytopenia/chemically induced
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Postnatally induced formation of the corpus callosum in acallosal mice on glia-coated cellulose bridges (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-03
    Beschreibung: Developing axons of the corpus callosum of mice are guided across the cerebral midline by a slinglike glial structure that forms transiently between the hemispheres. If the "sling" is cut at precallosal stages, the would-be callosal fibers whirl into paired neuromas adjacent to the longitudinal cerebral fissure. In experiments on such surgically acallosal animals, the aberrant commissural axons maintained a potential to regrow across the hemispheres at prenatal and early postnatal stages if they were presented with a properly aligned, glia-covered scaffold spanning the hemispheres.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Silver, J -- Ogawa, M Y -- NS-15731/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1067-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844928" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/physiology ; Brain/embryology/physiology ; Cellulose ; Corpus Callosum/embryology/*growth & development ; Embryo, Mammalian/physiology ; Fetus/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neuroglia/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 50
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    Recombination during gene transfer into mouse cells can restore the function of deleted genes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-14
    Beschreibung: Two plasmids containing nonoverlapping deletions of the herpes simplex virus thymidine kinase gene were introduced into thymidine kinase-deficient mouse L cells by DNA-mediated gene transfer. Thymidine kinase-producing transformants were generated by a mixture of the two plasmids at a frequency significantly greater than that generated by either plasmid alone. Southern blot analyses demonstrated that functional thymidine kinase genes were generated by homologous recombination between the two deletion mutants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Small, J -- Scangos, G -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294829" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cells, Cultured ; Chromosome Deletion ; *Genetic Engineering ; Mice ; Mutation ; *Plasmids ; *Recombination, Genetic ; Simplexvirus ; Thymidine Kinase/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 51
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    Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: Variants of the Dearing strain of reovirus type 3 with antigenically altered hemagglutinin proteins are much less neurovirulent than the parental virus. When injected intracerebrally into mice these variants infected a subset of the brain neurons that were infected by the parental virus. When injected intraperitoneally, the variants did not spread to the brain. These results indicate that minor modifications of the reovirus hemagglutinin dramatically alter the ability of the virus to spread into and injure the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spriggs, D R -- Bronson, R T -- Fields, B N -- NS-16998-01/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):505-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301010" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Brain/pathology ; Brain Diseases/*microbiology/pathology ; Hemagglutination Tests ; Mammalian orthoreovirus 3/immunology/*pathogenicity ; Mice ; Reoviridae/*pathogenicity ; Reoviridae Infections/microbiology/pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Rapid degradation of "new" acetylcholine receptors at neuromuscular junctions (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-07
    Beschreibung: Acetylcholine receptors at innervated neuromuscular junctions are very stable, with half-lives reported to be 6 to 13 days. Their turnover is described as a first-order process, implying a single population of receptors. In this study, two subpopulations of acetylcholine receptors at normally innervated junctions have been identified. One has a rapid turnover rate with a half-life of 18.7 hours, similar to that of extrajunctional receptors, and the other has a slow turnover rate with a half-life of 12.4 days. The rapidly turned over subpopulation represents approximately 20 percent of the total junctional receptors. This finding may account for the discrepancies in previous reports of turnover rates and may explain the rapid reversibility in vivo of agents that "irreversibly" block acetylcholine receptors. This finding also implies that the synthesis rate of junctional acetylcholine receptors may be higher than previous estimates. The rapidly turned-over subpopulation may represent receptors that were newly inserted into the neuromuscular junction and that were not yet stabilized by an influence of the motor nerve.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stanley, E F -- Drachman, D B -- 5 P01 NS10920/NS/NINDS NIH HHS/ -- 5 R01 HD04817/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623057" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bungarotoxins ; Diaphragm ; Kinetics ; Mice ; Neuromuscular Junction/*metabolism ; Receptors, Cholinergic/biosynthesis/classification/*metabolism ; Synaptic Membranes/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 53
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    Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. One of these lines has continued to secrete immunoglobulin G1 (5 to 10 micrograms per milliliter) for over 16 months. The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srikumaran, S -- Guidry, A J -- Goldsby, R A -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):522-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403985" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/biosynthesis ; Cattle ; Cell Line ; Hybridomas/*immunology ; Immunoglobulin G/*biosynthesis/immunology/isolation & purification ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin M/immunology ; Mice ; Radioimmunoassay
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 54
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    Genes of the major histocompatibility complex in mouse and man (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-18
    Beschreibung: The genes of the major histocompatibility complex code for cell-surface molecules that play an important role in the generation of the immune response. These genes and molecules have been studied intensively over the last five decades by geneticists, biochemists, and immunologists, but only recently has the isolation of the genes by molecular biologists facilitated their precise characterization. Many surprising findings have been made concerning their structure, multiplicity, organization, function, and evolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmetz, M -- Hood, L -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):727-33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6356354" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Evolution ; Chromosome Mapping ; Genes ; H-2 Antigens/*genetics ; HLA Antigens/*genetics ; Histocompatibility Antigens/genetics ; Humans ; *Major Histocompatibility Complex ; Mice ; Polymorphism, Genetic ; Protein Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 55
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    Serological visualization of interleukin 2 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: Interleukin 2, a lymphokine that acts as a second signal of cellular immune response by way of its action as a T-cell growth factor, was morphologically identified by immunoperoxidase staining. With the use of a monoclonal antibody to interleukin 2 and several complex-forming antisera, the lymphokine was readily distinguished in cytocentrifuge preparations of peripheral blood leukocytes stimulated with a T-cell mitogen. When preparations of cloned interleukin 2 producer and responder cells were stained by the same procedures, discrete patterns of both responder and producer cell phenotypes were revealed. Interleukin 2 producer T cells exhibited a characteristic intense, ringlike cytoplasmic staining, whereas the responder cells (as exemplified by interleukin 2-dependent cell lines) exhibited a less intensive, spotlike membrane staining. In addition, intense membrane localization of interleukin 2, reminiscent of potential capping phenomena, could be observed in stained preparations of cloned responder cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmann, G -- Conlon, P -- Hefeneider, S -- Gillis, S -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344215" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Cell Line ; Humans ; Immunoenzyme Techniques ; Interleukin-2/*physiology ; Leukocytes/physiology ; Mice ; T-Lymphocytes/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 56
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    Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-26
    Beschreibung: Macrophages isolated from tumor-bearing patients as well as cultured human monocytes express Fc receptors that cross-react strongly with murine immunoglobulins of the G2a but only slightly or not at all with the G1, G2b, or G3 subclasses. Such macrophages in the presence of murine immunoglobulin G2a monoclonal antibodies to tumors mediated the killing of tumor cells in vitro. These data suggest that monoclonal antibodies of the G2a subclass may be useful in the immunotherapy of human cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steplewski, Z -- Lubeck, M D -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- CA-25874/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):865-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879183" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/*immunology ; Cells, Cultured ; Cytotoxicity, Immunologic ; Humans ; *Immunity, Cellular ; Immunoglobulin G/immunology ; Immunotherapy ; Macrophages/*immunology ; Mice ; Monocytes/immunology ; Neoplasms, Experimental/immunology/therapy ; Receptors, Fc/*immunology ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 57
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    Biogenesis of ornithine transcarbamylase in spfash mutant mice: two cytoplasmic precursors, one mitochondrial enzyme (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-28
    Beschreibung: Extracts of liver from hemizygous affected mice with the X-linked spfash mutation have 5 to 10 percent of normal ornithine transcarbamylase (OTC) activity, yet the homogeneous enzyme isolated from these extracts is identical to that in controls. The OTC messenger RNA from mutant livers programs the synthesis of two distinct OTC precursor polypeptides--one normal in size, the other distinctly elongated. Both precursors are imported and proteolytically processed by mitochondria, but only the normal one is assembled into active trimer. This novel phenotype may result from a mutation in the structural gene for OTC leading, primarily, to aberrant splicing of OTC messenger RNA and, secondarily, to formation of a structurally altered precursor whose posttranslational pathway is ultimately futile because its mature mitochondrial form is not capable of assembly and functional expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, L E -- Kalousek, F -- Orsulak, M D -- AM 09527/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):426-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623083" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Genes ; Liver/enzymology ; Macromolecular Substances ; Mice ; Mice, Mutant Strains/genetics/physiology ; Mitochondria, Liver/enzymology ; Mutation ; Ornithine Carbamoyltransferase/*genetics ; Protein Precursors/genetics ; Protein Processing, Post-Translational ; RNA, Messenger/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 58
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    Deformed whiskers in mice infected with certain exogenous murine leukemia viruses (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Mice infected at birth with replication competent Friend, Moloney, CasBr-M, C2S-M, and 1504-A murine leukemia viruses developed abnormalities of the vibrissae consisting of erratic curvature, shortening, and loss. A number of other virus strains, as well as endogenous AKR-type ecotropic virus and AKR-type, mink cell focus-inducing (MCF) viruses, did not produce these abnormalities. In mice with erythroid and myeloid leukemia, the perivibrissal sinus is the site of extramedullary hematopoiesis, but this did not appear to be the basis of the deformities. Genetic evidence indicated that newly arisen MCF-type recombinant viruses are involved in the pathogenesis of the abnormalities, at least with some of the virus systems studied.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowe, W P -- N01-AI-22673/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):562-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306769" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AKR murine leukemia virus ; Animals ; Friend murine leukemia virus ; Hair/*pathology ; Leukemia Virus, Murine ; Leukemia, Experimental/*pathology ; Mice ; Mice, Inbred AKR ; Mice, Inbred C57BL ; Moloney murine leukemia virus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 59
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    Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-23
    Beschreibung: The cloned complementary DNA pMCT-1, which contains an intracisternal A particle long-terminal repeat, is more highly expressed in a mouse colon tumor than in the normal mouse colon. In situ hybridization of biotin-substituted pMCT-1 to fixed frozen sections shows that expression of pMCT-1 is seen throughout the tumor and is highly heterogeneous on a cellular basis, while expression is undetectable in any cell in the normal colonic mucosa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Royston, M E -- Augenlicht, L H -- CA 22367/CA/NCI NIH HHS/ -- CA 33383/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6689218" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biotin ; Colon/*analysis ; Colonic Neoplasms/*genetics/pathology ; Dna ; Interphase ; Intestinal Mucosa/analysis ; Male ; Mice ; Mice, Inbred BALB C ; *Nucleic Acid Hybridization ; RNA, Neoplasm/*genetics ; Repetitive Sequences, Nucleic Acid ; *Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 60
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    A cancer-associated lactate dehydrogenase is expressed in normal retina (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-15
    Beschreibung: An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase k, is found in high concentrations in cultured cells transformed by the Kirsten murine sarcoma virus and in many human cancer tissues. In experiments described here high levels of a lactate dehydrogenase k activity were detected in extracts of normal rodent retina. This activity had the same key properties as the human tumor isozyme, namely, a highly cathodic electrophoretic mobility and inhibition of enzymatic activity by oxygen and 5',5'-dipurinenucleoside tetraphosphates. Expression of this activity in the retina may be related to the high aerobic glycolysis characteristic of the retina, a metabolic feature shared with many tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saavedra, R A -- Anderson, G R -- CA32022/CA/NCI NIH HHS/ -- GM28098/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 15;221(4607):291-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857286" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Transformation, Neoplastic/metabolism ; Chickens ; Electrophoresis ; Glycolysis ; Guinea Pigs ; Humans ; Isoenzymes ; L-Lactate Dehydrogenase/antagonists & inhibitors/*metabolism ; Mice ; Mice, Inbred Strains ; Neoplasms/*enzymology ; Oxygen/pharmacology ; Rats ; Retina/*enzymology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 61
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    Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-07
    Beschreibung: A model for studying the growth of primary tumors of human endometrium and its regulation by 17 beta-estradiol has been developed in which ovariectomized nude mice are used as recipients. The receptors for sex steroids are maintained during serial transplantation of the tumor in this system. Although the rate of growth of receptor-negative endometrial tumors transplanted into ovariectomized nude mice is unaffected by the sustained presence or absence of estradiol, the growth of receptor-positive tumors is significantly increased by estradiol. Receptor-positive tumors treated with estradiol produced elevated concentrations of progesterone receptor. That the progesterone receptor is functional in this tumor is evident from the induction of estradiol 17 beta-dehydrogenase activity upon progestin administration. These findings are consistent with receptor-mediated regulation of growth of endometrial carcinoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Satyaswaroop, P G -- Zaino, R J -- Mortel, R -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):58-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849115" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/metabolism/*pathology ; Animals ; Castration ; Estradiol/*physiology ; Female ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Transplantation, Heterologous ; Uterine Neoplasms/metabolism/*pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 62
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    Altered activity patterns during development reduce neural tuning (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: Neonatal mice were reared in an acoustic environment that repetitively entrained activity in a large proportion of primary auditory afferents during the period when the frequency tuning of auditory neurons normally develops. The tuning curves obtained from these mice were significantly broader than those of normally reared mice of the same age. This suggests that the normal frequency tuning of neurons was prevented or delayed by synchronizing the pattern of activity imposed on the auditory pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sanes, D H -- Constantine-Paton, M -- 5T32GM07312/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612332" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acoustic Stimulation ; Animals ; Animals, Newborn ; Auditory Pathways/*physiology ; Evoked Potentials, Auditory ; Inferior Colliculi/physiology ; Mice ; Mice, Inbred C57BL ; Models, Neurological
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 63
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    Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-25
    Beschreibung: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Senger, D R -- Galli, S J -- Dvorak, A M -- Perruzzi, C A -- Harvey, V S -- Dvorak, H F -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):983-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823562" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Ascites/physiopathology ; Ascitic Fluid/physiology ; *Capillary Permeability ; Cricetinae ; Guinea Pigs ; Mice ; Neoplasms, Experimental/*physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 64
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 65
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    Thrombin stimulation of guanosine 3',5'-monophosphate formation in murine neuroblastoma cells (clone N1E-115) (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Thrombin, the central regulatory enzyme in coagulation, when incubated in nanomolar concentrations with murine neuroblastoma cells produced a rapid and marked increase in tritiated guanosine 3',5'-monophosphate (cyclic GMP) formation that was blocked by hirudin and competitively antagonized by dansylarginine N-(3-ethyl-1,5-pentanediyl)amide. Diisopropylphosphofluoridate-inactivated thrombin as well as the serine protease trypsin were markedly less potent and less effective than alpha-thrombin in producing this effect. Thrombin-stimulated cyclic GMP formation was inhibited by mepacrine and nordihydroguaiaretic acid but unaffected by indomethacin, suggesting that lipoxygenase metabolites of arachidonic acid are involved in the response. These results suggest that a thrombin-like protease in the brain may be involved with the function of neurons or that thrombin interactions with nerve cells, such as those following cerebral hemorrhage or other trauma of the central nervous system, may be important in the subsequent neuropathology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snider, R M -- Richelson, E -- HL07111/HL/NHLBI NIH HHS/ -- MH27692/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):566-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306770" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arginine/analogs & derivatives/pharmacology ; Blood Platelets/physiology ; Catechols/pharmacology ; Clone Cells ; Cyclic GMP/analysis/*biosynthesis ; *Dansyl Compounds ; Hirudins/pharmacology ; Indomethacin/pharmacology ; Masoprocol ; Mice ; Neuroblastoma/analysis/*metabolism ; Thrombin/analysis/*pharmacology ; Trypsin/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-19
    Beschreibung: A genomic clone consisting of the Moloney leukemia proviral genome with moderately repetitive mouse sequences was microinjected into the pronucleus of a mouse zygote. An animal was derived that carried multiple copies of proviral DNA in a tandem array. No evidence for homologous recombination was obtained. The viral genome was expressed in this animal and was transmitted as a single unit to its offspring. Subsequent breeding studies revealed that the proviral DNA had integrated on an X chromosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stewart, C -- Harbers, K -- Jahner, D -- Jaenisch, R -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):760-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6683871" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Nucleus/physiology ; Female ; Gene Expression Regulation ; Genes, Viral ; Mice ; Microinjections ; Moloney murine leukemia virus/*genetics ; Recombination, Genetic ; Sex Chromosomes/*physiology ; X Chromosome/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 67
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    Stable antibody-producing murine hybridomas (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-11
    Beschreibung: A method is described for obtaining antibody-producing hybridomas that are preferentially retained in cultures of fused mouse spleen and myeloma cells. Hybridomas are produced by fusing mouse myeloma cells that are deficient in adenosine phosphoribosyltransferase (APRT) with mouse spleen cells containing Robertsonian 8.12 translocation chromosomes. The cell fusion mixtures are exposed to a culture medium that can be utilized only by APRT-positive cells, which results in the elimination of both unfused APRT-deficient myeloma cells and non-antibody-producing APRT-deficient hybridomas that arise by segregation of the 8.12 translocation chromosomes containing the APRT genes and the active heavy chain immunoglobulin gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taggart, R T -- Samloff, I M -- 1 P01 CA 16042/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1228-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6402815" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenine Phosphoribosyltransferase/deficiency ; Animals ; Dosage Compensation, Genetic ; Hybridomas/*physiology ; Immunoglobulin Heavy Chains/genetics ; Mice ; Mice, Mutant Strains ; Selection, Genetic ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 68
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    Inhibition by alcohols of the localization of radioactive nitrosonornicotine in sites of tumor formation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-01
    Beschreibung: Oral administration of ethanol, n-butanol, or t-butanol to mice 20 minutes before injection of carbon-14-labeled nitrosonornicotine inhibited the localization of radioactivity in bronchial and salivary duct epithelium and in the liver. Localization of radioactivity in the nasal epithelium and esophagus was not significantly reduced. These alcohols therefore may selectively inhibit tumor formation in three of the five sites where this carcinogen typically acts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waddell, W J -- Marlowe, C -- New York, N.Y. -- Science. 1983 Jul 1;221(4605):51-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857261" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 1-Butanol ; Alcohol Drinking ; Alcohols/*pharmacology ; Animals ; Butanols/pharmacology ; Carcinogens/*antagonists & inhibitors ; Ethanol/pharmacology ; Humans ; Liver/drug effects ; Lung/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasms/*chemically induced ; Nitrosamines/*pharmacology ; Salivary Glands/drug effects ; Smoking ; tert-Butyl Alcohol
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 70
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    Pierce's disease of grapevines: isolation of the causal bacterium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-06
    Beschreibung: A Gram-negative, rod-shaped bacterium has been consistently isolated from grapevines with Pierce's disease. Grapevines inoculated with the bacterium developed Pierce's disease, and the bacterium was reisolated from the plants. The bacterium was serologically and ultrastructurallv indistinguishable from the one in naturally infected plants, and also indistinguishable from a bacterium isolated from almonds with almond leaf scorch disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, M J -- Purcell, A H -- Thomson, S V -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):75-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Pathology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569487" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Agglutination Tests ; Animals ; Cell Wall/ultrastructure ; Gram-Negative Bacteria/cytology/immunology/*isolation & ; purification/pathogenicity ; Hemiptera/microbiology ; Insect Vectors/microbiology ; Male ; Mice ; Plant Diseases/*microbiology ; Prunus/microbiology ; Rabbits ; Vitis/*microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    (S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-05-05
    Beschreibung: (S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Clercq, E -- Descamps, J -- De Somer, P -- Holy, A -- New York, N.Y. -- Science. 1978 May 5;200(4341):UNKNOWN.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205946" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenine/*analogs & derivatives/pharmacology ; Animals ; *Antiviral Agents ; Cytopathogenic Effect, Viral/drug effects ; Female ; Measles virus/drug effects ; Mice ; Simplexvirus/drug effects ; Vaccinia virus/drug effects ; Vesicular stomatitis Indiana virus/drug effects ; Virus Replication/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 72
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    Ethanol: modifications of acute intoxication by divalent cations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-17
    Beschreibung: Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Tyler, T D -- Harris, R A -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343251" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alcoholic Intoxication/*physiopathology ; Animals ; Body Temperature Regulation/drug effects ; Calcimycin/pharmacology ; Calcium/antagonists & inhibitors/*physiology ; Cations, Divalent ; Dose-Response Relationship, Drug ; Drug Synergism ; Female ; Humans ; Lasalocid/pharmacology ; Male ; Mice ; Movement/drug effects ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Sustained release of alcohol: subcutaneous silastic implants in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-31
    Beschreibung: A sustained-release device for use in ethanol dependence studies in mice is described. The Silastic device, dubbed SERT (sustained ethanol release tube), holds 0.35 milliliter of 95 percent ethanol (by volume) and is implanted under the skin of the back where it releases ethanol for up to 12 hours, with no observable tissue damage. The device may be adaptable to the release of other volatile liquids or drugs, in other animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Erickson, C K -- Koch, K I -- Mehta, C S -- McGinity, J W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564551" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alcoholic Intoxication/etiology ; Alcoholism/*etiology ; Animals ; *Disease Models, Animal ; Drug Administration Schedule ; Drug Implants ; Drug Tolerance ; Ethanol/*administration & dosage ; Humans ; Mice ; Silicone Elastomers
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-04
    Beschreibung: HIX virus cloned from Moloney leukemia virus stocks is a nondefective, leukemogenic, and amphotropic murine oncornavirus with a recombinant-type major glycoprotein. Although Moloney leukemia virus stocks generally contain little or no free amphotropic virus, dilution analysis of several virus stocks and the examination of virus progeny from individual foci revealed that HIX virus is present and functionally coated with ecotropic Moloney virus envelopes. Because most mice have serum factors that inactivate recombinant viruses, masking may represent a general survival mechanism for HIX as well as other analogous recombinant viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischinger, P J -- Blevins, C S -- Dunlop, N M -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):457-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663667" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Genes, Viral ; Glycoproteins/immunology ; Leukemia, Experimental/*microbiology ; Lymphoma/*microbiology ; Mice ; Mice, Inbred BALB C/microbiology ; Mice, Inbred Strains/microbiology ; Moloney murine leukemia virus/classification/*genetics/immunology ; Recombination, Genetic ; Species Specificity ; Viral Proteins/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    Memory: modification of anisomycin-induced amnesia by stimulants and depressants (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-20
    Beschreibung: Mice were trained in a passive (foot shock)avoidance task. When administered after training, the stimulants caffeine or nicotine blocked amnesia for the task that had been produced by injections of the protein synthesis inhibitor anisomycin given prior to training. With foot shock at a higher intensity, anisomycin did not produce amnesia by itself, but the administration of the depressants chloral hydrate or sodium phenobarbital after training did cause amnesia. Stimulants and depressants did not have an appreciable influence on the overall degree of protein synthesis inhibition produced by anisomycin. The results support the hypothesis that arousal after training is an important factor in the conversion of short-term to long-term memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flood, J F -- Bennett, E L -- Orme, A E -- Rosenzweig, M R -- Jarvik, M E -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):324-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619461" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anisomycin/*pharmacology ; Avoidance Learning/*drug effects ; Brain/*drug effects ; Caffeine/pharmacology ; Chloral Hydrate/pharmacology ; Drug Interactions ; Male ; Memory/*drug effects ; Mice ; Nerve Tissue Proteins/biosynthesis ; Nicotine/pharmacology ; Phenobarbital/pharmacology ; Pyrrolidines/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 76
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    Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-18
    Beschreibung: Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floros, J -- Chang, H -- Baserga, R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):651-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675253" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cell Cycle ; Cell Line ; Cell Nucleus/*metabolism ; Chickens ; Cytoplasm/physiology ; DNA/*biosynthesis ; Liver/ultrastructure ; Mutation ; Temperature ; Xenopus
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    A nonpeptide morphine-like compound: immunocytochemical localization in the mouse brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-27
    Beschreibung: A nonpeptide morphine-like compound (MLC) which cross reacts with morphine-specific antibodies has been localized with the use of immunocytochemistry. This morphine-like compound is found in neuronal perikarya or processes (or both) in nuclei related to vestibular, cerebellar, and raphe systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gintzler, A R -- Gershon, M D -- Spector, S -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):447-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/339350" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Brain Chemistry ; Cerebellum/analysis ; Cerebral Aqueduct/analysis ; Cross Reactions ; Immunoenzyme Techniques ; Mice ; Morphine/*immunology ; Raphe Nuclei/analysis ; Vestibular Nuclei/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 78
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    Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-05-19
    Beschreibung: A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant, 1,3-dichloro-2-propanone, is a potent mutagen in the absence of such activation. A flame retardant with similar structure, tris-(2,3-dibromopropyl)phosphate (tris-BP), was shown previously to be a mutagen, to cause sterility in animals, to be a carcinogen, and to be absorbed through human skin. These and other flame retardants have characteristic nuclear magnetic resonance spectra that can be used to determine which flame retardant is present in commercially purchased sleepwear. Sleepwear treated with tris-BP, Fyrol FR2, and other chemical additives was being sold in late 1977.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, M D -- Blum, A -- Ames, B N -- New York, N.Y. -- Science. 1978 May 19;200(4343):785-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347576" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biotransformation ; Flame Retardants/*toxicity ; Hydrocarbons, Chlorinated/toxicity ; Liver/metabolism ; Mice ; *Mutagens ; Organophosphorus Compounds/*toxicity ; Salmonella typhimurium/drug effects ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 79
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    Endosteal marrow: a rich source of hematopoietic stem cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-31
    Beschreibung: Hematopoietic cells isolated from the endosteal bone surface, that is,the endosteal marrow cells, were found to consist mainly (60 to 80 percent) of lymphoid and late-stage normoblast-like cells. Unlike the cells they resemble, the endosteal marrow cells showed an affinity for Sudan black, demonstrable nucleoli (Feulgen reaction), and an absence of hemoglobin. Assays showed that over one-half of the endosteal marrow cell population may be the colony-forming units, the CFU-S of Till and McCulloch. Thus, high concentrations of stem cells could be obtained from the endosteal bone surface by means of the present isolation technique.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gong, J K -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/75570" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bone Marrow Cells ; Cell Nucleolus/ultrastructure ; Female ; Hematopoiesis ; Hematopoietic Stem Cells/*cytology ; Lymphocytes/ultrastructure ; Male ; Mice ; Rats ; Spleen/cytology ; Staining and Labeling
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    Retrograde amnesia produced by several treatments: evidence for a common neurobiological mechanism (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-07-28
    Beschreibung: This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gold, P E -- Sternberg, D B -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208153" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amnesia/*etiology ; Amnesia, Retrograde/*etiology/prevention & control ; Amygdala/physiopathology ; Animals ; Avoidance Learning/drug effects ; Cerebral Cortex/physiopathology ; Cycloheximide/antagonists & inhibitors ; Ditiocarb/antagonists & inhibitors ; Electric Stimulation ; Humans ; Memory/*drug effects ; Mice ; Phenoxybenzamine/*pharmacology ; Rats ; Seizures/complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-22
    Beschreibung: An abnormality in retinal guanosine 3,5-monophosphate (cyclic GMP) metabolism is demonstrated in the inherited rod-cone dysplasis of Irish Setter dogs. Affected visual cells are deficient in cyclic GMP phosphodiesterase activity and have elevated levels of cyclic GMP. The biochemical abnormalities observed in affected retinas of Irish Setters are similar to those in the retinas of mice with inherited retinal degeneration before visual cell degeneration begins. A defect in cyclic GMP metabolism may be characteristic of early-onset degenerative diseases of the retina, possibly including those that affect humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aquirre, G -- Farber, D -- Lolley, R -- Fletcher, R T -- Chader, G J -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1133-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210508" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3',5'-Cyclic-GMP Phosphodiesterases/*deficiency ; Animals ; Cell Differentiation ; Chromosome Aberrations/genetics/metabolism/pathology/veterinary ; Chromosome Disorders ; Cyclic GMP/*metabolism ; Dog Diseases/genetics/*metabolism/pathology ; Dogs ; Kinetics ; Mice ; Photoreceptor Cells/metabolism/pathology ; Retina/enzymology/*metabolism/pathology ; Retinal Degeneration/genetics/metabolism/pathology/*veterinary
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-12-22
    Beschreibung: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    Magnetic microspheres prepared by redox polymerization used in a cell separation based on gangliosides (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-06-02
    Beschreibung: A facile method is described for making magnetic microspheres that bind specifically to cell surfaces, in order to separate cells magnetophoretically. Control over the sizes of the spheres is effected by using their magnetic cores as part of a redox polymerization system. The use of the microspheres is demonstrated with a separation involving C-1300 neuroblastoma cells, 10% of which express the ganglioside GM1 in their membranes. The GM1-containing cells were separated with better than 99% purity, while the deficient cells were obtained at least 98% pure. The separation, which was carried out under sterile conditions, required only 6 minutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronick, P L -- Campbell, G L -- Joseph, K -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653356" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Cell Separation/*methods ; *Gangliosides ; Magnetics ; Microspheres ; Neoplasms, Experimental/pathology ; Neuroblastoma/pathology ; Oxidation-Reduction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-02-03
    Beschreibung: The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bone Marrow Cells ; Cell Differentiation ; Cells, Cultured ; Colony-Stimulating Factors/*physiology ; Feedback ; Glycoproteins/*physiology ; Granulocytes/*cytology ; *Hematopoiesis ; Humans ; Leukocytes/*cytology ; Macrophages/cytology/*physiology ; Mice ; Models, Biological ; Monocytes/*physiology ; Prostaglandins E/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    Enkephalin-containing neurons visualized in spinal cord cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-04
    Beschreibung: Neuronal cells, axons, and terminals containing immunoreactive enkephalin have been visualized in cultures of dissociated fetal spinal cord. These cultures may provide a valuable system in which to explore the effects of chronic drug treatment on the physiology of enkephalin-containing cells and their interactions with other cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neale, J H -- Barker, J L -- Uhl, G R -- Snyder, S H -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):467-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351811" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Fluorescent Antibody Technique ; Ganglia, Spinal/metabolism ; Mice ; Neurons/*metabolism ; Spinal Cord/cytology/embryology/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 86
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    Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-11
    Beschreibung: Reovirus type 3, passaged in pancreatic beta-cell cultures, produced an insulitis when inoculated into 1- to 2-week-old mice. By means of a double-label antibody technique, in which we used fluorescein-labeled antibody to reovirus and rhodamine-labeled antibody to insulin, reovirus antigens were found in beta cells. By electron microscopy, viral particles in different stages of morphogenesis were observed in insulin-containing beta cells but not glucagon-containing alpha cells. The infection resulted in destruction of beta cells, reduction in the insulin content of the pancreas, and alteration in the host's capacity to respond normally to a glucose tolerance test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onodera, T -- Jenson, A B -- Yoon, J W -- Notkins, A L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):529-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, Viral/analysis ; Cells, Cultured ; Diabetes Mellitus, Experimental/etiology/metabolism/*microbiology ; Diabetes Mellitus, Type 1/microbiology ; Insulin/metabolism ; Islets of Langerhans/metabolism/*microbiology ; Mammalian orthoreovirus 3/immunology ; Mice ; Reoviridae Infections/*complications ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-04-21
    Beschreibung: delta9-Tetrahydrocannabinol (delta9-THC), added to the limit of its solubility, did not compete with tritiated 17beta-estradiol for binding to estrogen receptor sites in mouse mammary or uterine cytosols. On sucrose density gradients of low-ionic strength, mammary cytosol labeled with [3H]estradiol exhibited a binding peak near the "8S" region typical of estrogen receptor whereas in cytosol labeled with delta9-[3H]THC binding was limited to the nonspecific 4- to 5S region. Differences in sedimentation properties and reciprocal competition studies strongly refute previous claims that delta-9-THC binds to estrogen receptor and that by so doing it directly acts as an estrogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okey, A B -- Bondy, G P -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):312-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635586" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding, Competitive ; Cytosol/metabolism ; Dronabinol/*metabolism ; Estradiol/*metabolism ; Female ; Mammary Glands, Animal/metabolism ; Mice ; Molecular Weight ; Receptors, Drug/*metabolism ; Receptors, Estrogen/isolation & purification/*metabolism ; Uterus/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    Visualization of a guinea pig T lymphocyte surface component cross-reactive with immunoglobulin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-27
    Beschreibung: Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine k chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marchalonis, J J -- Bucana, C -- Hoyer, L -- Warr, G W -- Hanna, M G Jr -- New York, N.Y. -- Science. 1978 Jan 27;199(4327):433-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/74094" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cross Reactions ; Epitopes ; Guinea Pigs ; Immunoglobulin Fab Fragments ; Immunoglobulin G ; Immunologic Techniques ; Mice ; Receptors, Antigen, B-Cell/*analysis ; Rosette Formation ; Species Specificity ; T-Lymphocytes/*immunology ; Thymus Gland/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-12-01
    Beschreibung: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Ultraviolet radiation--induced chromosomal abnormalities in fetal fibroblasts from New Zealand black mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-09-08
    Beschreibung: Fibroblasts from New Zealand Black mouse fetuses manifest increased frequency of chromosomal breaks and interchanges after exposure to ultraviolet radiation when compared with cells from BABL/c fetuses. This chromosomal instability is similar to what has been reported in cells from patients with xeroderma pigmentosum and may be related to the chromosomally abnormal clones and malignancy previously reported in adult New Zealand Black mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, A L -- Fialkow, P G -- Salo, A -- New York, N.Y. -- Science. 1978 Sep 8;201(4359):920-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684417" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; *Chromosome Aberrations ; Chromosomes/*radiation effects ; Disease Models, Animal ; Dose-Response Relationship, Radiation ; Mice ; Mice, Inbred BALB C/physiology ; Mice, Inbred NZB/*physiology ; *Ultraviolet Rays ; Xeroderma Pigmentosum/physiopathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    The LDH virus: an interfering biological contaminant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-04-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, V -- Spackman, D H -- Santisteban, G A -- Dalldorf, G -- Hellstrom, I -- Hellstrom, K E -- Lance, E M -- Rowson, K E -- Mahy, B W -- Alexander, P -- Stock, C C -- Sjogren, H O -- Hollander, V P -- Horzinek, M C -- New York, N.Y. -- Science. 1978 Apr 14;200(4338):124-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/263259" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Lactate dehydrogenase-elevating virus ; Mice ; Neoplasm Transplantation ; Neoplasms, Experimental/microbiology ; Virus Diseases/microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    6-Mercaptopurine treatment of pregnant mice: effects on second and third generations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-07-07
    Beschreibung: The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reimers, T J -- Sluss, P M -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663638" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 6-Mercaptopurine/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Fetal Death/*chemically induced ; Fetus/drug effects ; Germ Cells/*drug effects ; Infertility, Female/*chemically induced ; Litter Size/drug effects ; Mice ; Ovary/cytology/drug effects/embryology ; Pregnancy ; Pregnancy, Animal/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 93
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-07-07
    Beschreibung: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 94
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    Morphological alterations in hippocampus after long-term alcohol consumption in mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-08-18
    Beschreibung: Golgi methods were used to examine the hippocampus of laboratory mice that received alcohol-containing or control diets for 4 months followed by a 2-month alcohol-free period. Long-term alcohol consumption resulted in a significant loss of dendritic spines on hippocampal pyramidal cells and dentate granule cells. This study provides evidence that long-term alcohol consumption, in the absence of malnutrition, produces morphological damage to the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Riley, J N -- Walker, D W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):646-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566953" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alcoholism/*pathology ; Animals ; Dendrites/ultrastructure ; *Disease Models, Animal ; Female ; Hippocampus/*pathology ; Humans ; Mice ; Pyramidal Tracts/pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 95
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    Myosin: immunofluorescent localization in neuronal and glial cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-03-31
    Beschreibung: The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to react with two different myosin antibodies. The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roisen, F -- Inczedy-Marcsek, M -- Hsu, L -- Yorke, W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1445-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343252" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Cytoplasm/ultrastructure ; Fluorescent Antibody Technique ; Ganglia, Spinal/cytology ; Myosins/*metabolism ; Neuroglia/*metabolism/ultrastructure ; Neurons/*metabolism/ultrastructure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 96
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-04-28
    Beschreibung: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 97
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    Membrane potentials of mitochondria (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-02-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rottenberg, H -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):568-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622562" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Energy Metabolism ; *Membrane Potentials/drug effects ; Mice ; Microelectrodes ; Mitochondria/*physiology ; Valinomycin/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 98
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    Prevention of death from metastases by immune RNA therapy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-10-06
    Beschreibung: The effect of immune RNA treatment on the incidence of death from pulmonary metastases was studied in C57BL/6J mice after excision of a B16 murine melanoma. Immune RNA was extracted from the lymphoid tissues of guinea pigs immunized with B16 tumor and then incubated in vitro with normal C57BL/6J mouse splenocytes. Mice receiving intraperitoneal injections of these RNA-treated syngeneic splenocytes after the primary B16 isograft was resectioned showed significantly improved long-term survival (42 to 67 percent in three successive experiments) as compared to control mice (0 to 20 percent survival) receiving untreated splenocytes. The effect of RNA treatment was tumor-specific and ribonuclease sensitive. The results suggest that immunotherapy with immune RNA may be of benefit to certain patients after surgery for cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, B S -- Onikul, S R -- Mannick, J A -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):59-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694519" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Immunotherapy/methods ; Lung Neoplasms/prevention & control ; Lymphocytes/*immunology ; Melanoma/immunology ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/*prevention & control ; Neoplasms, Experimental/immunology ; RNA/immunology/*therapeutic use ; Spleen/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 99
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    Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-07-14
    Beschreibung: The adenosine 3',5'-monophosphate (cyclic AMP) levels of mouse lymphocytes rose and fell sharply 10 hours after stimulation with concanavalin A. Treatment of the cells with indomethacin reversibly prevented the increase in cyclic AMP and the subsequent onset of DNA synthesis. When the heightened cyclic AMP before S phase was maintained by either inhibiting phosphodiesterase or by adding the 8-bromo derivative of cyclic AMP, DNA synthesis was also blocked. Both the increase and decrease in cyclic AMP appear to be required for progression of lymphocytes into the S phase of growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, T -- Sheppard, J R -- Foker, J E -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/208147" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacology ; Animals ; Cell Cycle/drug effects ; *Cell Division/drug effects ; Concanavalin A/antagonists & inhibitors ; Cyclic AMP/analogs & derivatives/*metabolism/pharmacology ; DNA/*biosynthesis ; Indomethacin/pharmacology ; *Lymphocyte Activation/drug effects ; Lymphocytes/*metabolism ; Mice ; RNA/biosynthesis ; Spleen/cytology
    Print ISSN: 0036-8075
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 100
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    Human breast cancer: androgen action mediated by estrogen receptor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-02-17
    Beschreibung: Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zava, D T -- McGuire, W L -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):787-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622569" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Androgens/*pharmacology ; Breast Neoplasms/*metabolism ; Cell Line ; Cell Nucleus/drug effects/metabolism ; Cytoplasm/drug effects/metabolism ; Dihydrotestosterone/pharmacology ; Humans ; Receptors, Androgen/drug effects ; Receptors, Estrogen/drug effects/*physiology ; Receptors, Glucocorticoid/drug effects/metabolism ; Receptors, Progesterone/drug effects/metabolism ; Stimulation, Chemical ; Translocation, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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