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  • BIOSCIENCES  (685)
  • 1980-1984
  • 1970-1974  (685)
  • 1935-1939
  • 1973  (307)
  • 1972  (378)
  • 1938
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Years
  • 1980-1984
  • 1970-1974  (685)
  • 1935-1939
Year
  • 1
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    Auditory system (1973)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The physical correlations of hearing, i.e. the acoustic stimuli, are reported. The auditory system, consisting of external ear, middle ear, inner ear, organ of Corti, basilar membrane, hair cells, inner hair cells, outer hair cells, innervation of hair cells, and transducer mechanisms, is discussed. Both conductive and sensorineural hearing losses are also examined.
    Keywords: BIOSCIENCES
    Type: BioTechnol., Inc. Bioastronaut. Data Book, 2d Ed.; p 667-691
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  • 2
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    Toxicology (1973)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Oxygen toxicity is examined, including the effects of oxygen partial pressure variations on toxicity and oxygen effects on ozone and nitrogen dioxide toxicity. Toxicity of fuels and oxidizers, such as hydrazines, are reported. Carbon monoxide, spacecraft threshold limit values, emergency exposure limits, spacecraft contaminants, and water quality standards for space missions are briefly summarized.
    Keywords: BIOSCIENCES
    Type: BioTechnol., Inc. Bioastronaut. Data Book, 2d Ed.; p 455-487
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  • 3
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    Biomedical experiments. Part A: Biostack experiment (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The biostack experiment is described which was designed to study the biologic effects of individual heavy nuclei of galactic cosmic radiation during space flight outside the magnetosphere of the earth. Specifically, the biostack experiment was designed to promote research on the effects of high energy/high Z particles of galactic cosmic radiation on a broad spectrum of biologic systems, from the molecular to the highly organized and developed forms of life. The experiment was considered unique and scientifically meritorious because of its potential yield of information - currently unavailable on earth - on the interaction of biologic systems with the heavy particles of galactic cosmic radiation.
    Keywords: BIOSCIENCES
    Type: NASA. Lyndon B. Johnson Space Center Apollo 16 Prelim. Sci. Rept.; 10 p
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  • 4
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    The vestibular system (1973)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The end organs, central nervous system connections, and static and dynamic characteristics of the vestibular system are presented. Vestibular servation in man and vestibular side effect prevention from space missions involving artificial gravity generation are also considered. Vestibular models and design criteria for rotating space vehicles are appended.
    Keywords: BIOSCIENCES
    Type: BioTechnol., Inc. Bioastronaut. Data Book, 2d Ed.; p 533-609
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  • 5
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    Surveyor 3: Bacterium isolated from lunar retrieved television camera (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Microbial analysis was the first of several studies of the retrieved camera and was performed immediately after the camera was opened. The emphasis of the analysis was placed upon isolating microorganisms that could be potentially pathogenic for man. Every step in the retrieval of the Surveyor 3 television camera was analyzed for possible contamination sources, including camera contact by the astronauts, ingassing in the lunar and command module during the mission or at splashdown, and handling during quarantine, disassembly, and analysis at the Lunar Receiving Laboratory
    Keywords: BIOSCIENCES
    Type: Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 239-248
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  • 6
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    Microbial response to space environment, part B (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The performance of the microbial response to space environment experiment is considered excellent by all investigators. For most microbial systems, only preliminary survival data are available at this time. None of the available data indicate space flight-mediated changes in cell viability or recovery. One quite important observation has been made at this early date, however. The eggs produced after mice had been infected with N. dubius larvae demonstrated a significant decrease in hatchability when compared to identical ground controls. Except for the fact that the Apollo 16 flight larvae had been on board the command module, treatment of the flown larvae and ground control larvae was the same; neither had been exposed to UV irradiation. The significance and implications of this finding are currently being studied.
    Keywords: BIOSCIENCES
    Type: Apollo 16 Prelim. Sci. Rept.; 6 p
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  • 7
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    Visual light flash phenomenon, part C (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The Apollo 16 mission provided the opportunity to obtain additional data on the characteristics and frequency of the light flashes and also provided the first opportunity to obtain a direct physical record of incident cosmic ray particles with the Apollo light flash moving emulsion detector (ALFMED). The ALFMED is an electromechanical device that is worn on the head like a helmet and supports cosmic radiation-sensitive emulsions around the head of the test subject. Two light flash observation sessions were conducted during the mission: one during translunar coast and the second during transearth coast. Characteristics of the light flashes observed and reported by the Apollo crew members were generally similar to those reported on previous missions. Analyses of the ALFMED emulsion plates are proceeding as scheduled, although results are not yet available. The ALFMED results should provide conclusive evidence establishing the correlation, if any, between the incident cosmic ray particles and the perception of light flashes as reported by Apollo crew members.
    Keywords: BIOSCIENCES
    Type: Apollo 16 Prelim. Sci. Rept.; 4 p
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  • 8
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    Vision (1973)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: Some data on human vision, important in present and projected space activities, are presented. Visual environment and performance and structure of the visual system are also considered. Visual perception during stress is included.
    Keywords: BIOSCIENCES
    Type: BioTechnol., Inc. Bioastronaut. Data Book, 2d Ed.; p 611-665
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  • 9
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    Respiratory system (1973)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: The general anatomy and function of the human respiratory system is summarized. Breathing movements, control of breathing, lung volumes and capacities, mechanical relations, and factors relevant to respiratory support and equipment design are discussed.
    Keywords: BIOSCIENCES
    Type: BioTechnol., Inc. Bioastronaut. Data Book, 2d Ed.; p 489-531
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  • 10
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    Microbiological sampling of returned Surveyor 3 electrical cabling (1972)
    In:  CASI
    Details
    Publication Date: 2005-11-30
    Description: A piece of electrical wiring bundle running from the television camera to another part of the spacecraft was selected for microbiological examination. Sampling methods are discussed. The results presented show that no viable microorganisms were recovered from the part of the Surveyor 3 cable which was tested. Factors that could have contributed to the sterility of the cable are thermal vacuum testing, natural dieoff, change in pressure during launch, and lunar vacuum and temperature.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Analysis of Surveyor 3 Mater. and Phot. Returned by Apollo 12; p 248-251
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  • 11
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    Subjective and nystagmus reactions considered in relation to models of vestibular function (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Modelling will become increasingly important as more knowledge is accumulated, because it offers advantages in predicting reactions of individuals in a variety of situations, including novel aerospace environments, and in specifying a few parameters which should have considerable clinical significance. However, the need for continuing experimental crosschecks of these models has been illustrated by several sets of results which would not have been predicted by any existing models.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 211-219
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  • 12
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    Artifacts produced during electrical stimulation of the vestibular nerve in cats (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Evidence is presented to indicate that evoked potentials in the recurrent laryngeal, the cervical sympathetic, and the phrenic nerve, commonly reported as being elicited by vestibular nerve stimulation, may be due to stimulation of structures other than the vestibular nerve. Experiments carried out in decerebrated cats indicated that stimulation of the petrous bone and not that of the vestibular nerve is responsible for the genesis of evoked potentials in the recurrent laryngeal and the cervical sympathetic nerves. The phrenic response to electrical stimulation applied through bipolar straight electrodes appears to be the result of stimulation of the facial nerve in the facial canal by current spread along the petrous bone, since stimulation of the suspended facial nerve evoked potentials only in the phrenic nerve and not in the recurrent laryngeal nerve. These findings indicate that autonomic components of motion sickness represent the secondary reactions and not the primary responses to vestibular stimulation.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 115-123
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  • 13
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    Perception of the upright and susceptibility to motion sickness as functions of angle of tilt and angular velocity in off-vertical rotation (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Motion sickness susceptibility of four normal subjects was measured in terms of duration of exposure necessary to evoke moderate malaise (MIIA) as a function of velocity in a chair rotated about a central axis tilted 10 deg with respect to gravitational upright. The subjects had little or no susceptibility to this type of rotation at 2.5 and 5.0 rpm, but with further increases in rate, the MIIA endpoint was always reached and with ever shorter test durations. Minimal provocative periods for all subjects were found at 15 or 20 rpm. Higher rotational rates dramatically reversed the vestibular stressor effect, and the subjects as a group tended to reach a plateau of relatively low susceptibility at 40 and 45 rpm. At these higher velocities, furthermore, the subjects essentially lost their sensation of being tilted off vertical. In the second half of the study, the effect of tilt angle was varied while the rotation rate was maintained at a constant 17.5 rpm. Two subjects were completely resistant to symptoms of motion sickness when rotated at 2.5 deg off vertical; with greater off-vertical angles, the susceptibility of all subjects increased sharply at first, then tapered off in a manner reflecting a Fechnerian function.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 99-103
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  • 14
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    Crew microbiology (DTO 71-19) (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: States of microbial imbalance as a result of human altitude chamber confinement occurred, for the most part, only in those genera and species of bacteria, yeast, and fungi which are classified as transients and are not part of the true indigenous flora of the crewmembers. Inasmuch as no crew illness events occurred and only subtle changes in the indigenous flora were noted, it appears that confinement of 56-days in a Skylab simulated environment does not mediate toward shifts in bacterial populations which have obvious clinical significance.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 12 p
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  • 15
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    Use of Lorente de No's neuron circuit model for describing acceleratory nystagmus (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Results of a previous metric analysis and an electronic simulation of acceleratory nystagmus are given. On this basis, a tentative mathematical model for describing acceleratory nystagmus is reported. The essential content of the model is Lorente de No's neuron circuit, to which the two-factor theory of excitation has been applied.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 263-272
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  • 16
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    Systems analysis of the vestibulo-ocular system (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The vestibulo-ocular system is examined from the standpoint of system theory. The evolution of a mathematical model of the vestibulo-ocular system in an attempt to match more and more experimental data is followed step by step. The final model explains many characteristics of the eye movement in vestibularly induced nystagmus. The analysis of the dynamic behavior of the model at the different stages of its development is illustrated in time domain, mainly in a qualitative way.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 237-249
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  • 17
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    Use of Steinhausen's model for describing periodic Coriolis star nystagmus (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Phase lag, maximal slow phase velocity, and beat frequency were measured in periodic Coriolis star nystagmus. The results have been described by Steinhausen's model of the semicircular canal system. Estimates of the biophysical constants have been obtained. It is concluded that this model is a good functional approximation for describing, and also for interpreting, the behavior of the system.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 251-262
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  • 18
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    On visual-vestibular interaction (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Experimental evidence is presented regarding visual vestibular interaction, and the results of three studies on the subject are briefly noted. An attempt to put together some of these observations with elementary notions of a visual vestibular interaction program is shown in the form of a flow chart representation of a possible model. This is a nonlinear model in which visual and vestibular influences are linearly weighted when they are in relative agreement but switch to the more believable one when they are in disagreement. A solution to the human space orientation problem is depicted by a schema for optimal subjective orientation based on several sensory modalities.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 205-210
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  • 19
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    Responses to rotating linear acceleration vectors considered in relation to a model of the otolith organs (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Human subjects were exposed to a linear acceleration vector that rotated in the transverse plane of the skull without angular counterrotation. Lateral eye movements showed a sinusoidal change in slow phase velocity and an asymmetry or bias in the same direction as vector rotation. A model is developed that attributes the oculomotor response to otolithic mechanisms. It is suggested that the bias component is the manifestation of torsion of the statoconial plaque relative to the base of the utricular macula and that the sinusoidal component represents the translational oscillation of the statoconia. The model subsumes a hypothetical neural mechanism which allows x- and y-axis accelerations to be resolved. Derivation of equations of motion for the statoconial plaque in torsion and translation, which take into account forces acting in shear and normal to the macula, yield estimates of bias and sinusoidal components that are in qualitative agreement with the diverse experimental findings.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 221-236
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  • 20
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    Otolithic influences on extraocular and intraocular muscles (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Selective stimulation of utricular gravireceptors leads to gross activation of the bulbar reticular formation where a strong interaction with evoked spino-bulbo-spinal reflex activity occurs. The utricular neurons encountered by microelectrodes in the lateral vestibular nuclei show four types of elicited activity; two of these display an increased firing rate, and two exhibit pronounced inhibitory effects. Application of a stimulus of long duration and constant intensity to the utricle has shown that rapid adaptation of the peripheral receptors is a prominent feature. The effects of selective utricular stimulation upon eye movements, as recorded by the corneoretinal potential method, have been studied in experiments on cats and monkeys and it can be firmly stated that prolonged stimulation of the utricle can evoke strong primary nystagmus, followed by a secondary nystagmus at the cessation of stimulation. The action of utricular stimulation on ocular reflexes has been examined further, with particular attention to evoked pupillary reactions in both cats and monkeys: constriction during the fast phase of the brisk conjugate eye movement, and dilatation during the flow phase.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 195-201
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  • 21
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    Habituation of vestibular responses: An overview (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: An historical survey of vestibular habituation experiments has been undertaken. Methodological problems are presented briefly, and the influence of arousal on vestibular responses is detailed. Data obtained from animals and from man are treated separately. At least for man, the term habituation may be better defined by a dynamic change in the form of vestibular responses than by a simple response reduction.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 157-193
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  • 22
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    Scanning electron microscopy of the vestibular end organs (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The vestibular end organs, after chemical fixation, were freeze dried, coated with gold and palladium, and studied in the scanning microscope. Scanning microscopy gives a good three dimensional view of the sensory areas and allows study of both gross anatomy and microstructures. Cross anatomical features of the structure of the ampullae are demonstrated. The form of the statoconia in different species of animals is shown. New aspects of the structure of the sensory hairs are revealed. The hair bundles in the central areas of the cristae and in the striola of the maculae differ structurally from the hair bundles at the periphery of the sensory regions. Furthermore, some hair bundles consisting of very short stereocilia were observed. The relationship between the cupula and the statoconial membrane to the epithelial surface is discussed.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 145-156
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  • 23
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    Anti-motion-sickness therapy (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Neither alterations in environmental temperature nor moderate intake of alcohol was found to alter susceptibility to motion sickness in subjects exposed to rotation in the Pensacola slow rotation room. Scopolamine with d-amphetamine was found to be the most effective preparation for the prevention of motion sickness under the experimental conditions of the studies reported here. Promethazine in combination with d-amphetamine was in the same range of effectiveness. Drug actions suggest that acetylcholine and norepinephrine may be involved in motion sickness.
    Keywords: BIOSCIENCES
    Type: NASA, Washinton Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 109-114
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  • 24
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    The ferrioxalate actinometry system of the microbial response to space environment experiment (M191) (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: The fluid actinometry portion of the Microbial Response to Space Environment Experiment (M191) was designed for measurement of the solar energy that penetrates certain optical filter systems during exposure in space. Potassium ferrioxalate was used to measure energy at peak wavelengths of 254, 280, and 300 nanometers because of its high degree of sensitivity and its linear response to the middle ultraviolet regions.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 169-178
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  • 25
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    Effects of space environment on T-7 bacteriophage and spores of Bacillus subtilis 168 (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Two strains of Bacillus subtilis were exposed to components of the ultraviolet spectrum in space. Both strains possess multiple genetic markers, and one of the strains is defective in the ability to repair ultraviolet damage. The T-7 bacteriophage of Escherichia coli was also exposed to selected wavelengths and energy levels of ultraviolet light in space. Preliminary findings do not reveal anomalies in survival rates. Data are not yet available on detailed genetic analyses.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 65-85
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  • 26
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    Background and general design of the microbial response to space environment experiment (M191) system (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Nine different species of organisms were exposed to space flight conditions during the Apollo 16 mission. Each test system was selected because it provided a quantitative method of evaluating some medically important phenomenon. The experiment design and each of the test systems are discussed.
    Keywords: BIOSCIENCES
    Type: Proc. of the Microbial Response to Space Environ. Symp.; p 3-19
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  • 27
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    Infectivity and egg production of Nematospiroides dubius as affected by space flight and ultraviolet irradiation (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Nematospiroides dubius was tested to determine the infective potential of the third stage larvae and the egg-production and egg-viability rates of the resulting adults after they are exposed to space flight and solar ultraviolet irradiation. The results are indicative that space-flown larvae exposed to solar ultraviolet irradiation were rendered noninfective in C57 mice, whereas flight control larvae that received no solar ultraviolet irradiation matured at the same rate as the ground control larvae. However, depressed egg viability was evident in the flight control larvae.
    Keywords: BIOSCIENCES
    Type: Proc. of the Microbial Response to Space Environ. Symp.; p 51-64
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  • 28
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    Helicopter crew/passenger vibration sensitivity - (1972)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Helicopter crew and passenger vibration sensitivity are presented. Pilot subjective ratings are established for discrete frequencies and the impact of combinations of harmonic frequencies is examined. A passenger long term comfort level and a short term limit are defined for discrete frequencies and compared with pilot ratings. The results show reasonable agreement between pilot and passenger. Subjective comfort levels obtained for mixed frequency environments clearly demonstrate the need for a multi-frequency criterion.
    Keywords: BIOSCIENCES
    Type: NASA. Langley Res. Center Symp. on Vehicle Ride Quality; p 143-153
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  • 29
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    The high energy multicharged particle exposure of the microbial ecology evaluation device on board the Apollo 16 spacecraft (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: The high energy multicharged cosmic-ray-particle exposure of the Microbial Ecology Evaluation Device package on board the Apollo 16 spacecraft was monitored using cellulose nitrate, Lexan polycarbonate, nuclear emulsion, and silver chloride crystal nuclear-track detectors. The results of the analysis of these detectors include the measured particle fluences, the linear energy transfer spectra, and the integral atomic number spectrum of stopping particle density. The linear energy transfer spectrum is used to compute the fractional cell loss in human kidney (T1) cells caused by heavy particles. Because the Microbial Ecology Evaluation Device was better shielded, the high-energy multicharged particle exposure was less than that measured on the crew passive dosimeters.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 179-189
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  • 30
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    Thermoluminescent dosimetry for the Apollo 16 microbial response to space environment experiment (M191) (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Lithium fluoride thermoluminescent chips were used to provide an integrated dose from the broad spectrum of ionizing radiation to the Microbial Response to Space Environment Experiment (M191). The chips were positioned in the flight hardware to provide data on ionizing radiation within specific volume segments. A uniform radiation dose of 4.8 x 0.001 plus or minus 2 x 0.0001 joule/kg resulted.
    Keywords: BIOSCIENCES
    Type: Proc. of the Microbial Response to Space Environ. Symp.; p 191-197
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  • 31
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    Effect of solar irradiation on extracellular enzymes of Aeromonas proteolytica (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: The bacterium Aeromonas proteolytica was selected for studying the effects of solar irradiation on extracellular enzymes because it produces an endopeptidase that is capable of degrading proteins and a hemolysin that is active in lysing human erythrocytes. Possible alterations in the rate of enzyme production in response to the test conditions are currently underway and are not available for this preliminary report. Completed viability studies are indicative that little difference exists among the survival curves derived for cells exposed to various components of ultraviolet irradiation in space.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 137-151
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  • 32
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    Postflight analyses of Bacillus thuringiensis organisms exposed to space flight conditions (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Cultures of B. thuringiensis returned from space flight appeared to be normal to slightly affected adversely in their ability to produce three toxins that affect insects. In addition, it can be stated that B. thuringiensis spores are very resistant to ultraviolet irradiation at the individual wavelengths and energy levels previously described. Full sunlight, however, does have a detrimental effect on the viability of B. thuringiensis spores.
    Keywords: BIOSCIENCES
    Type: Proc. of the Microbial Response to Space Environ. Symp.; p 105-120
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  • 33
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    Mycological studies housed in the Apollo 16 microbial ecology evaluation device (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Survival, death, and phenotype count have yielded variation in the number of fungi recovered from the controls and the flight exposed cuvettes during preliminary analysis of postflight first phase data. Also the preliminary analysis was indicative that fungi exposed to specific space flight conditions demonstrated variable survival rates and phenotype counts. Specific space flight conditions included full light space exposure for Chaetomium globosum, exposure at 300- and 254-nanometer wavelengths for Rhodotorula rubra, full light and 280-nanometer wavelength exposure for Trichophyton terrestre, and 254-nanometer wavelength exposure for Saccharomyces cerevisiae. In general, phenotype counts for flight cuvettes and survival rates for control cuvettes were higher compared with the remaining cuvettes.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 121-135
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  • 34
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    Effects of space vacuum and solar ultraviolet irradiation (254 nanometers) on the colony forming ability of Bacillus subtilis spores (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-26
    Description: Bacillus subtilis spores are highly resistant to harsh environments. Therefore, in the Apollo 16 Microbial Response to Space Environment Experiment (M191), these spores were exposed to space vacuum or solar ultraviolet irradiation, or both, to estimate the change of survival for terrestrial organisms in space. The survival of the spores was determined in terms of colony-forming ability. Comparison of the flight results with results of simulation experiments on earth applying high vacuum or ultraviolet irradiation, or both, revealed no remarkable difference. Simultaneous exposure to both these space factors resulted in a synergistic effect (that is, an ultraviolet supersensitivity). Therefore, the change of survival in space is assumed to depend on the degree of protection against solar ultraviolet irradiation.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Proc. of the Microbial Response to Space Environ. Symp.; p 87-103
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  • 35
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    Fungi and bacteria (1973)
    In:  CASI
    Details
    Publication Date: 2006-04-02
    Description: Spacecraft equipment is usually protected from fungi and bacteria by incorporating a fungicide-bactericide in the material, by a fungicide-bactericide spray, or by reducing the relative humidity to a degree where growth will not take place. A unique method to protect delicate, expensive bearings in equipment was to maintain a pressure (with dry air or nitrogen) slightly above the outside atmosphere (few millibars) within the working parts of the equipment, thus preventing fungi from entering equipment.
    Keywords: BIOSCIENCES
    Type: Terrest. Environ. (Climatic) Criteria Guidelines for Use in Aerospace Vehicle Develop., 1973 Rev.; 2 p
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  • 36
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    Brain blood-flow changes during motion sickness (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The possibility of diminished blood flow in the brain is studied as one of the factors resulting from an increase in skeletal muscle blood volume concomitant with other characteristics of motion sickness. Thermistors are implanted in the thalamus of dogs and blood flow changes are recorded while they are subjected to sinusoidal movement on a two pole swing. Results of these initial steps in a proposed long term exploration of different areas of the brain are presented.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 105-107
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  • 37
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    Environmental noise experiment (DTO 71-22) (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Only general conclusions can be reached of the effect of Skylab simulation chamber noise on the crewmen. Two crewmen experienced a small hearing decrement in-chamber, but there was no pattern as to the ear and frequency affected. Temporary hearing threshold shifts were observed in all three crewmen postchamber. These postchamber threshold shifts were perhaps the most significant finding of the study. However, no lasting detrimental effects on the crew's hearing were found.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 8 p
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  • 38
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    Sleep-monitoring, experiment M133 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The Skylab sleep-monitoring experiment simulated the timelines and environment expected during a 56-day Skylab mission. Two crewmembers utilized the data acquisition and analysis hardware, and their sleep characteristics were studied in an online fashion during a number of all night recording sessions. Comparison of the results of online automatic analysis with those of postmission visual data analysis was favorable, confirming the feasibility of obtaining reliable objective information concerning sleep characteristics during the Skylab missions. One crewmember exhibited definite changes in certain sleep characteristics (e.g., increased sleep latency, increased time Awake during first third of night, and decreased total sleep time) during the mission.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Expt. Altitude Test (SMEAT); 21 p
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  • 39
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    Metabolic activity, experiment M171 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The Skylab metabolic activity experiment determines if man's metabolic effectiveness in doing mechanical work is progressively altered by a simulated Skylab environment, including environmental factors such as slightly increased pCO2. This test identified several hardware/procedural anomalies. The most important of these were: (1) the metabolic analyzer measured carbon dioxide production and expired water too high; (2) the ergometer load module failed under continuous high workload conditions; (3) a higher than desirable number of erroneous blood pressure measurements were recorded; (4) vital capacity measurements were unreliable; and (5) anticipated crew personal exercise needs to be more structured.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 15 p
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  • 40
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    Mineral balance, experiment M071 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Concern for the long term metabolic consequences of weightless flight was the basis for the conception of the Skylab medical experiment to measure mineral balance. Proper interpretation of obtained data that diminished atmospheric pressure has no appreciable effect, or at least no protective effect, on calcium metabolism. The absence of changes in calcium metabolism indicates that a stable baseline observation has been made for Skylab as far as the effects of atmosphere or calcium metabolism are concerned.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 12 p
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  • 41
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    Lower body negative pressure, experiment M092 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Evaluation of orthostatic intolerance has been achieved by the use of lower body negative pressure (LBNP). The LBNP technique, though independent of gravity, simulates its effect by exposing the legs and the lower abdomen to reduced ambient pressures. This LBNP experiment, conducted during the 56-day simulation of the Skylab environment, was designed to supply baseline information on cardiovascular responses to periodic orthostatic stress. Impaired orthostatic tolerance, manifested by the increased heart rate, diminished systolic and pulse pressure, and increased tendency to syncope in the upright position, or during LBNP, was not observed in this experiment.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 6 p
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  • 42
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    Vestibular mechanisms underlying certain problems in a rotating spacecraft (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Vestibular side effects are discussed with the aid of a conceptual framework based on an analysis of vestibular input-output relations. These side effects tend to fall into two main categories: (1) Reflex phenomena, and (2) motion sickness, a delayed epiphenomenon. Although the symptomatology of motion sickness is similar wherever experienced, both the eliciting stimuli and the opportunity to adapt may differ in different motion environments. These differences not only are exemplified when motion sickness is compared in a weightless and in a rotating environment, but they also point to important differences in the problem of preventing (or treating) motion sickness in these two very different environments.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 35-39
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  • 43
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    Red blood cell metabolism (M114), part D (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Statistically significant differences were found between Skylab simulation crews and controls for glycolytic enzymes. The absence of simultaneous controls for the pre- and postchamber analyses leaves the significance of the findings in the crew during these periods indeterminate.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Expt. Altitude Test (SMEAT); 2 p
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  • 44
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    Special hematologic effects (M115), part E (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: All routine hematological measurements for the Skylab simulation test were within normal astronaut population limits for the CDR, SPT, and PLT, with one exception: A significant lymphopenia was observed in the PLT during the post test period, possibly the reflection of increased adrenal corticoid secretion. No ultrastructural red cell membrane abnormalities were observed in any of the subjects, nor were any red corpuscle morphological abnormalities noted. Slight elevations in the PLT's red corpuscular potassium were observed in the younger corpuscles after chamber entrance and again upon egress. This probably represents newly released young red cells from hematopoietic tissue. Flame photometric analyses confirm the fact that potassium is indeed higher in the younger cells of all subjects examined.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 12 p
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  • 45
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    Investigation of man's immune system (M112), part B (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Fifty-six days of residence in a Skylab-type environment produce essentially no change in the reactivity of the human immune system, as typified by the rate of RNA or DNA synthesis in small lymphocytes. The one point of divergence between the Skylab simulation crew and previous Apollo crews, a marked depression in synthesis rates on the fourteenth day after the chamber study, may be due to some technical difficulty in the experiment. Lymphocyte morphology changes paralleled functional changes.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Expt. Altitude Test (SMEAT); 6 p
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  • 46
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    Hematology/immunology (M110 series) (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The hematology/immunology experiments in the Skylab mission study various aspects of the red blood cell, including its metabolism and life span, and blood volume changes under zero gravity conditions to determine the precise mechanism of the transient changes which have been seen on the relatively brief missions of the past.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 5 p
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  • 47
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    The role of perilymph in the response of the semicircular canals to angular acceleration (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: A new model for the response of the semicircular canals to angular motion is postulated. This model is based on evidence that the bony canal is not compartmentalized and assumes that the ampulla wall is highly flexible. It is shown that the perilymph induces a cupula displacement far greater than that produced by the endolymph alone. The predicted dynamic behavior of the canals on the basis of this model is found to be consistent with experimental observations.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 135-141
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  • 48
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    The vestibular system of the owl (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Five owls were given vestibular examinations, and two of them were sacrificed to provide serial histological sections of the temporal bones. The owls exhibited a curious variability in the postrotatory head nystagmus following abrupt deceleration; sometimes a brisk nystagnus with direction opposite to that appropriate to the stimulus would occur promptly after deceleration. It was found also that owls can exhibit a remarkable head stability during angular movement of the body about any axis passing through the skull. The vestibular apparatus in the owl is larger than in man, and a prominent crista neglecta is present. The tectorial membrane, the cupula, and the otolithic membranes of the utricle, saccule, and lagena are all attached to surfaces in addition to the surfaces hearing hair cells. These attachments are very substantial in the utricular otolithic membrane and in the cupula.
    Keywords: BIOSCIENCES
    Type: NASA, Washington Fifth Symp. on the Role of the Vestibular Organs in Space Exploration; p 127-132
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  • 49
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    Medical operations: Crew surgeon's report (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: To assure the safety and well being of the Skylab environment simulation crewmembers it was necessary to develop a medical safety plan with emergency procedures. All medical and nonmedical test and operations personnel, except those specifically exempted, were required to meet the medical standards and proficiency levels as established. Implemented programs included health care of the test crew and their families, occupational medical services for chamber operating personnel, clinical laboratory support and hypobaric and other emergency support.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 15 p
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  • 50
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    Effects of SMEAT on the oral health of crewmen (DTO 71-2) (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The oral health status of three astronauts was monitored before, during and after a 56-day simulation of the Skylab mission. Laboratory and clinical parameters which are considered to be ultimately related to dental impairments were evaluated. The most notable changes were observed in increased counts of mycoplasma and S. mutans, decreased counts of enteric bacilli, decreased saliva flow rates, increased secretory IgA and salivary lysozyme levels, and increased clinical scores of dental plaque, calculus and inflammation.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Expt. Altitude Test (SMEAT); 6 p
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  • 51
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    Bioassay of body fluids, experiment M073 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Body fluids were assayed in this experiment to demonstrate changes which might have occurred during the 56-day chamber study in fluid and electrolyte balance, in regulation of calcium metabolism, in overall physiological and emotional adaptation to the environment, and in regulation of metabolic processes.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 14 p
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  • 52
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    Bone mineral measurement, experiment M078 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Measurement tests revealed few deviations from baseline bone mineral measurements after 56 days in a Skylab-type environment. No mineral change was observed in the right radius. One individual, however, showed a possible mineral loss in the left os calcis and another gained mineral in the right ulna. The cause of the gain is unclear but may be attributable to the heavy exercise routines engaged in by the crewmember in question. Equipment problems were identified during the experiment and rectified.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 6 p
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  • 53
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    Blood volume and red cell life span (M113), part C (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Prechamber, in-chamber, and postchamber blood samples taken from Skylab simulation crewmembers did not indicate significant shortening of the red cell life span during the mission. This does not suggest that the space simulation environment could not be associated with red cell enzyme changes. It does show that any changes in enzymes were not sufficiently great to significantly shorten red cell survival. There was no evidence of bone marrow erythropoetic suppression nor was there any evidence of increased red cell destruction.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Expt. Altitude Test (SMEAT); 4 p
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  • 54
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    Cytogenetic studies of the blood (M111), part A (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The cytogenetic study of the crew appears to indicate that Skylab-type environmental conditions have no deleterious effect upon chromosomal material. The findings are, however, less clear-cut than might be desired, due in large measure to confounding of the experimental design by the administration of isotope injections for the purposes of other experiments and to the lack of control subjects.
    Keywords: BIOSCIENCES
    Type: NASA. Johnson Space Center Skylab Med. Altitude Test (SMEAT); 3 p
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  • 55
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    Program organization (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The Skylab medical experiments altitude test plan is outlined. Described are the scope and objectives of the program, the management system under which it would be conducted, requirements for configuration of the test facility, test control documentation, data processing, and detailed test objectives.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 5 p
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  • 56
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    Introduction (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: The objective of the Skylab medical experiment altitude test was to provide a nearly full scale simulation of a 56-day Skylab mission for studying physiological changes produced in man by the long term exposure to space conditions. Evaluated in the altitude chamber tests were human cardiovascular/hemodynamic responses, musculoskeletal/metabolic effects, endocrine/electrode factors, and neurophysiological indices.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 6 p
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  • 57
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    Construction of a mathematical model of the human body, taking the nonlinear rigidity of the spine into account (1973)
    In:  CASI
    Details
    Publication Date: 2006-03-28
    Description: A mathematical model of the human body was constructed, under the action of harmonic vibrations, in the 2.5-7 Hz frequency range. In this frequency range, the model of the human body as a vibrating system, with concentrated parameters is considered. Vertical movements of the seat and vertical components of vibrations of the human body are investigated.
    Keywords: BIOSCIENCES
    Type: Cybernetic Diagnostics of Mech. Systems with Vibro-acoustic Phenomena (NASA-TT-F-14899); p 38-40
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  • 58
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    A centre for accommodative vergence motor control (1973)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Latencies in accommodation, accommodative-vergence, and pupil-diameter responses to changing accommodation stimuli, as well as latencies in pupil response to light-intensity changes were measured. From the information obtained, a block diagram has been derived that uses the least number of blocks for representing the accommodation, accommodative-vergence, and pupil systems. The signal transmission delays over the various circuits of the model have been determined and compared to known experimental physiological-delay data. The results suggest the existence of a motor center that controls the accommodative vergence and is completely independent of the accommodation system.
    Keywords: BIOSCIENCES
    Type: Vision Research; 13; Dec. 197
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  • 59
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    Cardiac beta-adrenergic receptors and coronary hemodynamics in the conscious dog during hypoxic hypoxia. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: The mechanisms by which acute hypoxia (10% and 5% oxygen) mediates changes in coronary blood flow and cardiac function were investigated in the conscious dog. When the dogs breathed hypoxic gas mixtures through a tracheostomy, both arterial and coronary sinus oxygen tensions were significantly decreased. With 5% oxygen, there were significant increases in heart rate (25%), maximum left ventricular dP/dt (39%), left circumflex coronary artery blood flow (163%), and left ventricular oxygen consumption (52%), which were attenuated by beta-adrenergic blockage with propranolol. When electrical pacing was used to keep the ventricular rate constant during hypoxia, there was no significant difference in coronary blood flow before and after beta blockade. Beta-adrenergic receptor activity in the myocardium participates in the integrated response to hypoxia although it may not cause active vasodilation of the coronary vessels.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 43; Apr. 197
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  • 60
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    Effects of pentobarbital on plasma glucose and free fatty acids in the rat. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Hyperglycemia and hypolipemia were observed in rats after the injection of sodium pentobarbital. The observed changes were independent of whether the blood was collected by decapitation or by needle puncture of the aorta. The hyperglycemic response was caused by two factors including the stress of the injection per se and the pharmacological action of the drug. Hyperlipemia was observed at 5 min postinjection. However, pentobarbital decreased plasma free fatty acids by 15 min postinjection. Both the hyperglycemia and hypolipemia responses were dose dependent.
    Keywords: BIOSCIENCES
    Type: Society for Experimental Biology and Medicine; vol. 139
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  • 61
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    Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: This investigation set out to answer two questions: (1) are the distal alveoli in the terminal lung units less well perfused than the proximal alveoli, i.e., is there stratification of blood flow; and (2) if so, does this enhance gas exchange in the presence of stratified inequality of ventilation. Excised dog lungs were ventilated with saline and perfused with blood. Following single inspirations of xenon 133 in saline and various periods of breath holding, the expired xenon concentration against volume was measured and it confirmed marked stratified inequality of ventilation under these conditions. By measuring the rate of depletion of xenon from alveoli during a period of blood flow, we showed that the alveoli which emptied at the end of expiration had 16% less blood flow than those exhaling earlier. However, by measuring the xenon concentration in pulmonary venous blood, we found that about 10% less tracer was transferred from the alveoli into the blood when the inspired xenon was stratified within the respiratory zone. Thus while stratification of blood flow was confirmed, it was shown to impair rather than enhance the efficiency of gas transfer.
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 32; Mar. 197
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  • 62
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    Viruslike particles in the tissues of normal and gamma-irradiated Drosophila melanogaster. (1972)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: A new finding of viruslike particles in the salivary and accessory glands, muscles, and nerves of normal and gamma-irradiated Drosophila melanogaster is discussed. In morphology and size, the particles seemed identical to those described in earlier reports. On the basis of the available results, it cannot be affirmed that these particles infect only dividing cells, since they are found in all the Drosophila tissues so far examined. Their relation to the aging process is felt to be an interesting subject for further study.
    Keywords: BIOSCIENCES
    Type: Journal of Invertebrate Pathology; 19; Jan. 197
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  • 63
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    Effects of exposing rats to 100% oxygen at 450 and 600 mm Hg on in vitro liver and adipose tissue lipid synthesis. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: Male rats (260-285 gm) were exposed to 100% oxygen at 450 or 600 mm Hg for 1 to 4 days. Rats maintained at 450 mm Hg ate 92% the amount of food eaten by ad libitum controls maintained at sea level conditions. At 600 mm Hg, the food intake was 77% of the ad libitum controls. No difference was found in the plasma level of glucose, free fatty acids, and corticosterone between oxygen exposed rats and their respective pair-fed controls. The in vitro conversion of acetate into fatty acids by adipose tissue from rats exposed at 450 mm Hg for 2, 3, or 4 days was significantly increased above pair-fed controls and ad libitum controls. Increasing the oxygen pressure to 600 mm Hg abolished this increase, and in fact, reversed the increased synthesis to a significant decrease for the 4-day exposure.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 43; Mar. 197
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  • 64
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    Urological considerations in space medicine. (1972)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Urological problems encountered during the preparation phases of Biosatellite III, flight of Bonny the Space Monkey, are detailed. The solution to each problem is detailed. The catheter system employed, antibiotic coverage used, and bacteria encountered in the urine of the five animals are detailed. Urinary calcium levels in three ground based animals are illustrated. Testicular alterations encountered in all animals are mentioned. It is concluded that space flights of duration beyond nine days may present serious problems of a urological nature.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 43; Mar. 197
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  • 65
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    Organic molecules in space. (1972)
    In:  Other Sources
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    Publication Date: 2011-08-16
    Description: Examination of the question of chemical evolution. Observational evidence for the occurrence of some organic compounds in space is presented, and the likely existence of more complex molecules which are as yet undetected or unidentified is pointed out. This implies that massive solid objects, i.e., planets and asteroids, were accumulated from material which already contained a variety of organic compounds. The objects or regions of the galaxy studied are comets, interstellar space, prestellar nebulae, and cool stellar atmospheres.
    Keywords: BIOSCIENCES
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    Potential targets in the search for extraterrestrial life. (1972)
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    Publication Date: 2011-08-16
    Description: Discussion of the potential for increasing understanding of the origins of terrestrial life by examination of other planets. If living organisms should be found on another planet, they could only have been transported from an inhabited planet or originated independently. The fundamental chemical and structural attributes of terrestrial organisms are so remarkably uniform that any living forms outside the terrestrial blueprint would almost certainly be regarded as alien organisms. It has been shown experimentally by various investigators that life can exist in an extremely wide range of temperatures and pressures. The presence of an atmosphere appears to be necessary.
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  • 67
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    Planetary atmospheres. (1972)
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    Publication Date: 2011-08-16
    Description: Study of the composition of the atmospheres of the planets. Their wide variety is of interest in view of the fact that all nine planets were probably formed at the same time and out of the same chemically homogeneous mixture of gas and dust, i.e., the primitive solar nebula. The most likely explanation for this diversity in composition seems to be that the planetary atmospheres have undergone important evolutionary changes during their history of about 4.5 billion years. The early history of the earth's atmosphere is reviewed, as well as that of Venus and Mars. The most interesting aspect of Jupiter is that its present atmosphere seems to be composed of the same gases, hydrogen, methane, and ammonia, out of which the first living organisms are believed to have been synthesized on the earth.
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  • 68
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    Ultrastructure of Pseudomonas saccharophila at early and late log phase of growth. (1972)
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    Publication Date: 2011-08-16
    Description: Description of the fine structure of Pseudomonas saccarophila at the early log phase and the late log phase of growth, such as shown by electron microscopy with the aid of various techniques of preparation. The observations reported suggested that, under the experimental conditions applied, P. saccharophila multiplies by the method of constrictive division.
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 109; Feb. 197
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  • 69
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    Distribution and significance of carbon compounds on the moon. (1972)
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    Publication Date: 2011-08-16
    Description: Exploration of available information concerning carbon on the moon, following review of what is known about carbon on the earth, and consideration of the results of studies of meteorites, which have provided the first direct clues about extraterrestrial carbon. Carbon and carbon isotope composition data taken from Apollo 11 samples are tabulated. Carbon compounds produced by pyrolysis, extracted with benzene-methanol, extracted with water, and freed by acid treatment are discussed. Carbon and carbon compounds in lunar rocks and soils appear to be distributed heterogeneously.
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  • 70
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    Dietary carbohydrate increases brain tryptophan and decreases serum-free tryptophan (1973)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Nature; 244; July 6
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  • 71
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    Possibilities for the evolution of the genetic code from a preceding form (1973)
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    Publication Date: 2011-08-16
    Description: Analysis of the interaction between mRNA codons and tRNA anticodons suggests a model for the evolution of the genetic code. Modification of the nucleic acid following the anticodon is at present essential in both eukaryotes and prokaryotes to ensure fidelity of translation of codons starting with A, and the amino acids which could be coded for before the evolution of the modifying enzymes can be deduced.
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    Type: Nature; 246; Nov. 2
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  • 72
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    Noise coupling between accommodation and accommodative vergence (1973)
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    Publication Date: 2011-08-16
    Description: For monocular viewing, the fluctuations in accommodative lens power in the frequency range from 0.5 to 3 Hz were found to be considerably greater than those in accommodative vergence movements of the covered eye. Considering the close synkinesis between these motor responses for step changes or slow variations in accommodative stimulus, this finding is unexpected. This apparent lack of synkinesis is found to result mainly from the fact that the decrease in small-signal linear gain with increasing frequency is more rapid in the case of the accommodative vergence system than in the case of the accommodation system, rather than from some nonlinear phenomenon.
    Keywords: BIOSCIENCES
    Type: Vision Research; 13; Dec. 197
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  • 73
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    The effect of bedrest on adrenal function (1973)
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    Publication Date: 2011-08-16
    Description: Eight male subjects were subjected to continuous bedrest for 24-80 weeks for the purpose of studying metabolic responses. Three of the subjects did supine exercises daily during part of the study. Adrenal function was examined in relation to adrenal cortical and medullary excretions. The results reveal an increase in hydrocortisone throughout the test period, a decrease in norepinephrine and no change in epinephrine. These data suggest that exercise could decrease the severity of deconditioning caused by bedrest.
    Keywords: BIOSCIENCES
    Type: Space Life Sciences; 4; Sept
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  • 74
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    Prebiotic activation processes. (1973)
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    Publication Date: 2011-08-16
    Description: Questions regarding the combination of amino acids and ribonucleotides to polypeptides and polynucleotides are investigated. Each of the reactions considered occurs in the solid state in plausible prebiotic conditions. Together they provide the basis for a unified scheme of amino acid and nucleotide activation. Urea, imidazole and Mg(++) are essential catalytic components of the reaction mixtures. However, these compounds could probably be replaced by other organic molecules.
    Keywords: BIOSCIENCES
    Type: Nature; 244; Aug. 17
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  • 75
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    Effect of simulated lunar impact on the survival of bacterial spores. (1973)
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    Publication Date: 2011-08-16
    Description: In order to test the effect of impact on organisms, the survival of bacterial spores after being propelled at high velocity in Pyrex and plastic beads into crushed basalt was measured. The beads were fired into sterilized canisters by both a conventional powder and a light gas gun. Results indicate that at the minimum (2.4 km/sec) lunar capture velocity, the number of colony forming units (CFUs) decreased by five orders of magnitude, and at 5.5 km/sec, statistically a more probable capture velocity, no CFUs were found. The decrease in CFUs observed with increasing velocity indicates that the spores were most probably killed by the impact.
    Keywords: BIOSCIENCES
    Type: Space Life Sciences; 4; Apr. 197
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  • 76
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    Brain calcium - Role in temperature regulation. (1973)
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    Publication Date: 2011-08-16
    Description: Perfusion of the preoptic-anterior hypothalamus with excess calcium ion in ground squirrels produces a drop in core temperature. The magnitude of the drop is directly dependent on ambient temperature. Respiration, heart rate, and oxygen consumption are also reduced during perfusion of calcium ion. It is concluded that the depression of body temperature during calcium ion perfusion is due to generalized depression of the neurons of the preoptic-anterior hypothalamus.
    Keywords: BIOSCIENCES
    Type: Science; 181; Aug. 17
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  • 77
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    Changes in functional construction of bone in rats under conditions of simulated increased gravity. (1973)
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    Publication Date: 2011-08-16
    Description: An investigation was conducted to determine experimentally whether femur bones are altered in cross-sectional area or cross-sectional shape by chronic centrifugation at different G-levels in conformance to Wolff's law. It was found that the centrifuged animals exhibit on the average smaller body masses, femur lengths and femur cross sections, as compared to their corresponding age controls. The mean inhibitory effect of chronic centrifugation upon body and femur growth can be measured in a shortcut approximation by calculating the decrease of body masses and femoral dimensions on a percentage basis.
    Keywords: BIOSCIENCES
    Type: Zeitschrift fuer Anatomie und Entwicklungsgeschichte; 139; 1973
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  • 78
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    The presence of P700 in chloroplast fragments prepared by short time incubation with Triton X-100. (1972)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Biochimica et Biophysica Acta; 275; 1972
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  • 79
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    Lactate dehydrogenase from an extremely thermophilic bacillus. (1972)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Archiv fuer Mikrobiologie; 85; 1972
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  • 80
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    Disproportional changes in hematocrit, plasma volume, and proteins during exercise and bed rest. (1972)
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    Publication Date: 2011-08-16
    Description: The interrelationships between the changes in plasma volume, hematocrit, and plasma proteins during muscular exercise and bed rest were investigated. Proportionally, the changes in hematocrit are always smaller than the changes in plasma volume. For this reason changes in the concentration of blood constituents can only be quantitated on the basis of plasma volume changes. During short periods of intensive exercise, there was a small loss of plasma proteins. With prolonged submaximal exercise there was a net gain in plasma protein, which contributes to stabilization of the vascular volume. Prolonged bed rest induced hypoproteinemia; this loss of plasma protein probably plays an important role in recumbency hypovolemia.
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 33; July 197
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  • 81
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    Effect of artificial gravity on thermoregulation, respiratory metabolism and intermediary metabolism of animals (1973)
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    Publication Date: 2011-08-16
    Description: Metabolic alterations in animals exposed to radial acceleration are reported. Temperatures in acutely stressed animals dropped profoundly in correlation with decreased food consumption. Repeated exposure of the acutely stressed animal caused a decrease in hypothermic response whereas deceleration or reduction of G load did not significantly change body temperatures. Adrenal corticosteroids affected significantly the animal's recovery rate. No changes occured in body temperature patterns of chronically centrifuged animals after full adaptation; their respiratory rate increased very significantly in terms of CO2 output as did their glucose uptake by muscle tissues and their insulin responsiveness or sensitivity.
    Keywords: BIOSCIENCES
    Type: Regulatory Biol.: Depressed Metab.; p 27-51
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  • 82
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    Kinetic principles of interaction of components in complex biological systems (1973)
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    Publication Date: 2011-08-16
    Description: A biomathematical analysis of component interaction in biological systems is given. Two primary types of systems are discussed - open systems and closed systems. The applicability of these systems to life support equipment in spacecraft is analyzed and formulae are provided to demonstrate the effect (theoretical) of closed and open systems in life support systems.
    Keywords: BIOSCIENCES
    Type: Probl. of Space Biol., Vol. 19 (NASA-TT-F-761); p 173-278
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  • 83
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    Mass-energy metabolic characteristics of algae (1973)
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    Publication Date: 2011-08-16
    Description: A mathematical analysis is given for the mass energy characteristics of photosynthesizing algae. An engineering-biological approach to this allows for a detailed analysis of the characteristics for a broad spectrum of environmental situations in which such algae are used as a component of a life support system. Models of such systems are constructed and are employed to demonstrate actual and hypothetical situations. Computers are employed for this purpose.
    Keywords: BIOSCIENCES
    Type: Probl. of Space Biol., Vol. 19 (NASA-TT-F-761); p 77-171
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  • 84
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    The limits of the adaptation of life to extreme conditions (in connection with problems of exobiology) (1973)
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    Publication Date: 2011-08-16
    Description: Accommodation is discussed as a universal evolutionary principle which essentially will apply to all life forms, regardless of chemical base (carbon, silicon, etc.). Life forms must either adapt to extreme conditions or perish, and for any life form an extremum factor is any significant deviation in environmental parameters. The possibility of life forms existing in specific extraterrestrial environments is discussed, and a conclusion is drawn which unequivocally states that through many forms of accommodation life is possible in many different environments.
    Keywords: BIOSCIENCES
    Type: Probl. of Space Biol., Vol. 19 (NASA-TT-F-761); p 1-76
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  • 85
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    Effect of iron and salt on prodigiosin synthesis in Serratia marcescens. (1973)
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    Publication Date: 2011-08-16
    Description: Iron requirements of Serratia marcescens for growth and prodigiosin synthesis are investigated. Sodium chloride of sea salt is shown to be responsible for inhibition of prodigiosin synthesis in the microorganism. The role of sodium chloride in the terminal biosynthetic pathway of the pigment is discussed.
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 114; June 197
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  • 86
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    The prospect of life on Jupiter. (1973)
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    Publication Date: 2011-08-16
    Description: We have simulated electrical discharges in the Jovian atmosphere, using anhydrous methane-ammonia mixtures, and shown the formation of simple aliphatic nitriles, amino-nitriles, and their oligomers. Including hydrogen sulfide in the gas mixture, it appears that sulfur-containing amino-nitriles are not formed, since the hydrolysate of the products did not contain the corresponding amino-acids. There is a strong analogy between these reactions and the classical spark reactions simulating the primitive earth's atmosphere. We are attempting a closer simulation of Jupiter's atmosphere by using appropriate temperature and pressure conditions. It seems that prebiotic synthesis on Jupiter may have reached an advanced state. As an alternative approach we have tested the survival ability of common terrestrial microorganisms in aqueous media at 102 atmospheres pressure and at 20 C in a simulated Jovian atmosphere. E. coli, S. marcescens, A. aerogenes, and B. subtilis will all tolerate 24 hr under these conditions with little death.
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  • 87
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    Cardiac arrhythmias during exercise testing in healthy men. (1973)
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    Publication Date: 2011-08-16
    Description: Clinically healthy male executives who participate in a long-term physical conditioning program have demonstrated cardiac arrhythmia during and after periodic ergometric testing at submaximal and maximal levels. In 1,385 tests on 248 subjects, it was found that 34% of subjects demonstrated an arrhythmia at some time and 13% of subjects developed arrhythmia on more than one test. Premature systoles of ventricular origin were most common, but premature systoles of atrial origin, premature systoles of junctional origin, paroxysmal atrial tachycardia, atrioventricular block, wandering pacemaker, and pre-excitation were also seen. Careful post-test monitoring and pulse rate regulated training sessions are suggested for such programs.
    Keywords: BIOSCIENCES
    Type: Aerospace Medicine; 44; Mar. 197
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  • 88
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    Survival of Arthrobacter crystallopoietes during prolonged periods of extreme desiccation. (1973)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 113; Jan. 197
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  • 89
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    Circadian rhythm asynchrony in man during hypokinesis. (1972)
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    Publication Date: 2011-08-16
    Description: Posture and exercise were investigated as synchronizers of certain physiologic rhythms in eight healthy male subjects in a defined environment. Four subjects exercised during bed rest. Body temperature (BT), heart rate, plasma thyroid hormone, and plasma steroid data were obtained from the subjects for a 6-day ambulatory equilibration period before bed rest, 56 days of bed rest, and a 10-day recovery period after bed rest. The results indicate that the mechanism regulating the circadian rhythmicity of the cardiovascular system is rigorously controlled and independent of the endocrine system, while the BT rhythm is more closely aligned to the endocrine system.
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 33; Nov. 197
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  • 90
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    Method for analyses of cyclic physiological data that are nonstationary in time. (1972)
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    Publication Date: 2011-08-16
    Description: The proposed method of studying biologic rhythms permits the biologist to view physiological data dynamically without assuming that the data are stationary in time. Vector representation of data points is employed, and the summation of the vectors (train of vectors) produces a summation dial that is able to detect dynamic changes in the time of the peak as well as random walks (arrhythmia).
    Keywords: BIOSCIENCES
    Type: Journal of Applied Physiology; 33; Nov. 197
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  • 91
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    Properties of phosphoribulokinase from Thiobacillus neapolitanus. (1972)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 112; Oct. 197
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  • 92
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    Studies of the electron transport chain of extremely halophilic bacteria. VIII - Respiration-dependent detergent dissolution of cell envelopes. (1972)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Biochimica et Biophysica Acta; 282; 1972
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  • 93
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    Isolation of a polyvalent bacteriophage for Escherichia coli, Klebsiella pneumoniae, and Aerobacter aerogenes. (1972)
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    Publication Date: 2011-08-16
    Keywords: BIOSCIENCES
    Type: Journal of Virology; 9; May 1972
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  • 94
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    Lipid composition of growing and starving cells of Arthrobacter crystallopoietes. (1972)
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    Publication Date: 2011-08-16
    Description: Missing abstr.
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 111
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  • 95
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    Escape conditioning and low-frequency whole-body vibration - The effects of frequency, amplitude, and controls for noise and activation. (1972)
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    Publication Date: 2011-08-16
    Description: Seven experiments are reported on low-frequency whole-body vibration and rats' escape conditioning in a modified Skinner box. In the first three studies, conditioning was observed but was independent of frequency. In experiment four, the number of escape responses was directly related to vibration amplitude. Experiment five was a control for vibration noise and noise termination; experiments six and seven studied vibration-induced activation. Noise termination did not produce conditioning. In experiment six, subjects made more responses when responding led to termination than when it did not. In experiment seven, subjects preferred a bar which terminated vibration to one which did not.
    Keywords: BIOSCIENCES
    Type: Psychonomic Science; 27; May 10
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  • 96
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    Isolation and characterization of ultraviolet light-sensitive mutants of the blue-green alga Anacystis nidulans. (1972)
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    Publication Date: 2011-08-16
    Description: Three independently isolated ultraviolet light sensitive (uvs) mutants of Anacystis nidulans were characterized. Strain uvs-1 showed the highest sensitivity to UV by its greatly reduced photoreactivation capacity following irradiation. Pretreatment with caffeine suppressed the dark-survival curve of strain uvs-1, thus indicating the presence of excision enzymes involved in dark repair. Under 'black' and 'white' illumination, strain uvs-1 shows photorecovery properties comparable with wild-type cultures. Results indicate that strains uvs-1, uvs-35, and uvs-88 are probably genetically distinct UV-sensitive mutants.
    Keywords: BIOSCIENCES
    Type: Journal of Bacteriology; 110; June 197
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  • 97
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    Exobiology, Jupiter and life. (1972)
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    Publication Date: 2011-08-16
    Description: Recent experiments in an environmental chamber have shown that not even hardy terrestrial bacteria can survive on the Martian surface. The planet Jupiter is now considered by many to be the most likely place to find nonterrestrial life. Atmospheric simulation experiments for Jupiter that have been performed involve spark or semicorona discharges in mixtures of methane and ammonia at room temperature and a pressure lower than atmospheric. Terrestrial microorganisms have been shown capable of surviving 24 hr under a range of possible Jovian atmospheric conditions. The final mode of approach to the question of Jovian life concerns theoretical studies on the sort of chemical systems from which life could be generated.
    Keywords: BIOSCIENCES
    Type: Spaceflight; 14; June 197
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  • 98
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    Acute changes in the central nervous system of monkeys exposed to protons. (1972)
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    Publication Date: 2011-08-16
    Description: Study of the changes occurring in simian brain exposed to protons of varied energy, given in wide dose and dose-rate ranges. Results show that inflammatory reaction and glycogen accumulation in astrocytes occurred practically in all animals. Cerebral cortical necrosis, granule cell pyknosis, and inflammatory reaction occurred at doses far lower than effective for high-energy gamma radiation given other series of monkeys at comparable dose rates. Metallic impregnation, carried out in virtually all the animals tested, revealed a wide variation in glial response even at equal doses and dose rates in the same proton energy series. Proton energy effect, dose effect, dose-time effect, and dose-rate effect were evident in the various morphological categories investigated, but inconsistencies were encountered.
    Keywords: BIOSCIENCES
    Type: Journal of Neuropathology and Experimental Neurology; 31; Jan. 197
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  • 99
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    Methods for study of cardiovascular adaptation of small laboratory animals during exposure to altered gravity (1973)
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    Publication Date: 2011-08-16
    Description: Several new techniques are reported for studying cardiovascular circulation in small laboratory animals kept in metabolic chambers. Chronical cannulation, miniaturized membrane type heart-lung machines, a prototype walking chamber, and a fluorocarbon immersion method to simulate weightlessness are outlined. Differential hypothermia work on rat cancers provides localized embedding of radionuclides and other chemotherapeutical agents in tumors and increases at the same time blood circulation through the warmed tumor as compared to the rest of the cold body. Some successful clinical applications of combined chemotherapy and differential hypothermia in skin cancer, mammary tumors, and brain gliomas are described.
    Keywords: BIOSCIENCES
    Type: NASA. Wallops Station Regulatory Biol.: Depressed Metab.; p 158-177
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  • 100
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    The role of brown adipose tissue in temperature regulation (1973)
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    Publication Date: 2011-08-16
    Description: The thermogenetic capacities of brown adipose tissue were studied on marmots, rats and monkeys in response to cold exposure. All experiments indicated that the brown fat produced heat and slowed the cooling of tissues.
    Keywords: BIOSCIENCES
    Type: NASA. Wallops Station Regulatory Biol.: Depressed Metab.; p 139-157
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