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  • Rats, Inbred Strains  (50)
  • American Association for the Advancement of Science (AAAS)  (50)
  • 2005-2009
  • 1990-1994
  • 1980-1984  (50)
  • 1945-1949
  • 1925-1929
  • 1984  (32)
  • 1981  (18)
  • 1929
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (50)
Years
  • 2005-2009
  • 1990-1994
  • 1980-1984  (50)
  • 1945-1949
  • 1925-1929
Year
  • 1
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    Increased intracranial self-stimulation in rats after long-term administration of desipramine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: The effects of long- and short-term administration of the tricyclic antidepressant desipramine on intracranial self-stimulation in rats were studied with electrodes in the A10 region of the dopamine-containing cell bodies of the ventromedial tegmentum. Long-term desipramine administration resulted in a significant shift to the left in the ascending portion of the rate--current intensity function, indicating that the activity of the mesolimbic dopamine system was enhanced. These findings point to a possible dopaminergic mechanism of action of antidepressants and support speculations concerning the role of dopamine-containing neurons in the pathophysiology of depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fibiger, H C -- Phillips, A G -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):683-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7197394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Depression/physiopathology ; Desipramine/*administration & dosage ; Dopamine/*physiology ; Humans ; Limbic System/*physiology ; Male ; Rats ; Rats, Inbred Strains ; Self Stimulation/*drug effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Dietary restriction retards the age-associated loss of rat striatal dopaminergic receptors (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: In male Wistar rats subjected to dietary restriction by alternate days of feeding and fasting the normal age-associated loss of striatal dopamine receptors in the brain was substantially retarded. The mean survival time of the rats on the restricted diet was increased by approximately 40 percent compared to control rats given free access to food. Dopamine receptor concentrations in striata of 24-month-old rats that had been on a restricted diet since weaning were 50 percent higher than those of control animals of the same age, and essentially comparable to 3- and 6-month-old control rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levin, P -- Janda, J K -- Joseph, J A -- Ingram, D K -- Roth, G S -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):561-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291993" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Corpus Striatum/*metabolism ; *Diet ; Fasting ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Modulation of parallel fiber excitability by postsynaptically mediated changes in extracellular potassium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-16
    Description: Field potentials and extracellular potassium concentration ([K+]o) were simultaneously monitored in the molecular layer of the rat cerebellar cortex during stimulation of the parallel fibers. The synaptic field potential elicited by stimulation was reduced by several methods. Reduction of synaptic field potentials was accompanied by a marked increase in the excitability of the parallel fibers. This change in excitability was related to the degree of extracellular K+ accumulation associated with parallel fiber stimulation. These findings support the proposal that increases in [K+]o associated with activity in postsynaptic elements can modulate the excitability of presynaptic afferent fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malenka, R C -- Kocsis, J D -- Ransom, B R -- Waxman, S G -- NS 15589/NS/NINDS NIH HHS/ -- NS-00473/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280695" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/*physiology ; Animals ; Calcium/physiology ; Cerebellar Cortex/*physiology ; Evoked Potentials ; Extracellular Space/physiology ; Male ; Manganese/pharmacology ; Membrane Potentials ; Potassium/*physiology ; Rats ; Rats, Inbred Strains ; Synapses/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Electroconvulsive shock increases tyrosine hydroxylase activity in the brain and adrenal gland of the rat (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: A single application of electroconvulsive shock produced a rapid but short-lasting increase in tyrosine hydroxylase activity above control values in the rat adrenal medulla and striatum. After repeated electroconvulsive shock treatment (once per day for 7 days), tyrosine hydroxylase activity increased significantly in the locus ceruleus, nucleus of the tractus solitarius, hippocampus, cerebellum, and frontal cortex and remained elevated for 4 to 8 days. Adrenal tyrosine hydroxylase activity increased 1 day after the termination of repeated electroconvulsive shock treatments and remained elevated for at least 24 days, possibly reflecting the establishment of a new and higher steady-state level of catecholamine biosynthesis in the adrenal. These findings suggest that the persistent changes in tyrosine hydroxylase activity produced by repeated electroconvulsive shock may be a factor contributing to the long-lasting antidepressant effects of this treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masserano, J M -- Takimoto, G S -- Weiner, N -- NS 07927/NS/NINDS NIH HHS/ -- NS 09199/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):662-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117127" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*enzymology ; Animals ; Brain/*enzymology ; Corpus Striatum/enzymology ; *Electroshock ; Enzyme Induction ; Locus Coeruleus/enzymology ; Male ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine 3-Monooxygenase/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-23
    Description: Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altura, B M -- Altura, B T -- Gebrewold, A -- Ising, H -- Gunther, T -- HL18015/HL/NHLBI NIH HHS/ -- HL29600/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1315-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701524" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arterioles/pathology ; *Blood Pressure ; Capillaries/pathology ; Magnesium/blood ; Magnesium Deficiency/pathology/*physiopathology ; Male ; *Microcirculation ; Rats ; Rats, Inbred Strains ; *Vasoconstriction ; Venules/pathology
    Print ISSN: 0036-8075
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  • 6
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    Inhibition of aldosterone production by an atrial extract (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-01
    Description: Crude extracts of rat atria reduced the basal amount of aldosterone released from rat zona glomerulosa cells and partially inhibited aldosterone stimulation by adrenocorticotropic hormone and angiotensin II. The destruction of this activity by trypsin suggests that the active factor is a peptide, possibly atrial natriuretic factor. These data suggest that atrial natriuretic factor affects sodium excretion by the kidneys both directly and through the inhibition of aldosterone production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Atarashi, K -- Mulrow, P J -- Franco-Saenz, R -- Snajdar, R -- Rapp, J -- New York, N.Y. -- Science. 1984 Jun 1;224(4652):992-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326267" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/pharmacology ; Aldosterone/*biosynthesis ; Angiotensin II/pharmacology ; Animals ; *Atrial Function ; Dogs ; Female ; Kidney/drug effects/metabolism ; Mineralocorticoid Receptor Antagonists/pharmacology ; Natriuresis/drug effects ; Rats ; Rats, Inbred Strains ; Trypsin/pharmacology
    Print ISSN: 0036-8075
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  • 7
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    Fast and slow magnetic phenomena in focal epileptic seizures (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: The magnetic fields associated with penicillin-induced focal epilepsy were measured in laboratory rats. Interictal magnetic spikes were similar to those previously observed in humans with focal seizure disorders. The magnetic fields of the seizure itself displayed both slow and fast phenomena, reversing in direction on opposite sides of the head.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barth, D S -- Sutherling, W -- Beatty, J -- 1-R01-NS20806-01/NS/NINDS NIH HHS/ -- 1K07NS00678-01A1/NS/NINDS NIH HHS/ -- 5-S07 RR07009/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):855-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Electroencephalography ; *Electromagnetic Fields ; *Electromagnetic Phenomena ; Electrophysiology ; Epilepsies, Partial/*physiopathology ; Humans ; Penicillins/pharmacology ; Rats ; Rats, Inbred Strains ; Seizures/physiopathology
    Print ISSN: 0036-8075
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  • 8
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    Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baekkeskov, S -- Dyrberg, T -- Lernmark, A -- AM26190/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1348-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6374896" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/*immunology ; Diabetes Mellitus, Experimental/*immunology ; Diabetes Mellitus, Type 1/immunology ; Humans ; Islets of Langerhans/*immunology ; Rats ; Rats, Inbred Strains ; Rats, Mutant Strains
    Print ISSN: 0036-8075
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  • 9
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    Decreased neuronal inhibition in vitro after long-term administration of ethanol (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-22
    Description: The pathophysiology of brain dysfunction was studied with an animal model of chronic alcoholism. Rats were fed a liquid diet with or without ethanol for 20 weeks and then the diet without ethanol for three more weeks. Hippocampal slices were prepared and intracellular recordings were obtained from dentate granule and CA1 cells. Significant depression of orthodromically elicited inhibitory postsynaptic potentials and postspike afterhyperpolarizations was observed in neurons from ethanol-exposed animals. No differences were observed in other active or passive membrane characteristics. These results suggest that a loss of neuronal inhibition could contribute to brain dysfunction in chronic alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Durand, D -- Carlen, P L -- New York, N.Y. -- Science. 1984 Jun 22;224(4655):1359-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328654" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Alcoholism/physiopathology ; Animals ; Calcium/physiology ; Ethanol/*pharmacology ; Humans ; Ion Channels/drug effects ; Male ; Membrane Potentials/drug effects ; Neurons/*drug effects ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Intrahippocampal septal grafts ameliorate learning impairments in aged rats (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-03
    Description: Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2 1/2 to 3 months, the rats with grafts, but not the controls, had improved their performance in a spatial learning test. Their improvement was due, at least in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. Thus, the action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite for the observed functional recovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gage, F H -- Bjorklund, A -- Stenevi, U -- Dunnett, S B -- Kelly, P A -- AG 03766/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):533-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539949" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Disease Models, Animal ; Female ; Fetus ; Hippocampus/embryology/growth & development/*transplantation ; Humans ; *Learning ; Memory Disorders/*physiopathology ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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  • 11
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    Isolation and culture of a tetraploid subpopulation of smooth muscle cells from the normal rat aorta (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: Smooth muscle cells with 4C (double diploid) DNA content have been found in major arteries. The proportion of 4C cells increases with normal aging and with hypertension. These cells may represent a state of arrest at the G2 phase of the cell cycle or may be examples of true tetraploidy. Flow cytometric cell sorting was used to isolate 4C smooth muscle cells from the rat aorta, and the cells were cultured. Flow cytometry, Feulgen microdensitometry, and karyotyping of the progeny of the 4C cells established the presence of true tetraploid cells. These findings demonstrate the presence of reproductively viable tetraploid cells in a normal mammalian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Rosen, E M -- Shapiro, H M -- Zoller, L C -- Myrick, K -- Levenson, S E -- Christenson, L -- 5-P01-CA-12662/CA/NCI NIH HHS/ -- AG00599/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494901" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Thoracic/analysis/*cytology ; Cells, Cultured ; DNA/analysis ; Flow Cytometry ; Humans ; Karyotyping ; Muscle, Smooth, Vascular/analysis/*cytology ; *Polyploidy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, J D -- Lau, W -- Kwiat, G -- Goetzl, E J -- AM 32634/AM/NIADDK NIH HHS/ -- DE 05369/DE/NIDCR NIH HHS/ -- HL 31809/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):743-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6087456" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/*pharmacology ; Animals ; Bradykinin/pharmacology ; Dinoprostone ; Indomethacin/pharmacology ; Leukotriene B4/analogs & derivatives/*pharmacology ; Male ; Neutrophils/*drug effects/physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins E/pharmacology ; Rats ; Rats, Inbred Strains ; SRS-A/pharmacology
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  • 13
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    Dioxin in soil: bioavailability after ingestion by rats and guinea pigs (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McConnell, E E -- Lucier, G W -- Rumbaugh, R C -- Albro, P W -- Harvan, D J -- Hass, J R -- Harris, M W -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695194" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aryl Hydrocarbon Hydroxylases/biosynthesis ; Biological Availability ; Body Weight/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Dioxins/*metabolism ; Eating ; Enzyme Induction ; Female ; Guinea Pigs ; Intestinal Absorption ; Liver/drug effects ; Male ; Microsomes, Liver/enzymology ; Organ Size/drug effects ; Rats ; Rats, Inbred Strains ; *Soil Pollutants/toxicity ; Tetrachlorodibenzodioxin/*metabolism/toxicity ; Thymus Gland/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-07
    Description: Two micrograms of prostaglandin E2 injected into the lateral ventricle of the brain in rats had the same anorectic and gastrointestinal motor effect as central administration of 0.02 unit of calcitonin. The effects of calcitonin were blocked by a previous intracerebroventricular administration of 0.25 milligram of indomethacin. These results suggest that both anorectic and gastrointestinal motor effects of calcitonin are centrally mediated by the release of prostaglandins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fargeas, M J -- Fioramonti, J -- Bueno, L -- New York, N.Y. -- Science. 1984 Sep 7;225(4666):1050-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6591429" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/*physiology ; Calcitonin/administration & dosage/*pharmacology ; Dinoprostone ; Feeding Behavior/*drug effects ; Gastrointestinal Motility/*drug effects ; Indomethacin/administration & dosage/pharmacology ; Injections, Intraventricular ; Male ; Prostaglandins E/administration & dosage/*pharmacology ; Rats ; Rats, Inbred Strains
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  • 15
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    Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-07
    Description: Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faris, P L -- McLaughlin, C L -- Baile, C A -- Olney, J W -- Komisaruk, B R -- ES-07066/ES/NIEHS NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505689" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Cholecystokinin/immunology/*physiology ; *Drug Tolerance ; Immunization ; Male ; Morphine/*pharmacology ; Pain/*physiology ; Rats ; Rats, Inbred Strains ; Time Factors
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  • 16
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    Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-27
    Description: An important early event in mammalian gustatory transduction with respect to sodium chloride has been found to be the passage of sodium ions through specific transport pathways in the apical region of the taste bud. The inward current caused by sodium chloride placed on the mucosal surface of an in vitro preparation of rat dorsal lingual epithelium can be substantially reduced by the blocker of sodium ion transport, amiloride. The data show (i) that amiloride is a specific blocker of the chorda tympani response to sodium chloride, but not to potassium chloride, (ii) that the sodium and potassium gustatory systems are largely independent at the peripheral level, and (iii) that the classical ion taste "receptor" is actually a specific transport pathway permitting the cation to enter the taste-bud cell and thereby to spread depolarizing current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heck, G L -- Mierson, S -- DeSimone, J A -- NS 13767/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 27;223(4634):403-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6691151" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/*pharmacology ; Animals ; Biological Transport/drug effects ; Epithelium/metabolism ; Potassium Chloride/pharmacology ; Pyrazines/*pharmacology ; Rats ; Rats, Inbred Strains ; Sodium/*metabolism ; Sodium Chloride/pharmacology ; Taste/*physiology ; Taste Buds/innervation/*metabolism
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  • 17
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    Surface-active biomaterials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-09
    Description: Since the discovery in 1969 of a man-made surface-active material that would bond to bone, a range of materials with the same ability has been developed. These include glass, glass-ceramic, and ceramic materials which have a range of reaction rates and from which it should be possible to select a surface-active material for a specific application. The available materials and their similarities, differences, and current clinical applications are reviewed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hench, L L -- Wilson, J -- New York, N.Y. -- Science. 1984 Nov 9;226(4675):630-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6093253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biocompatible Materials/metabolism/therapeutic use ; Bone Cements/therapeutic use ; Bone and Bones/metabolism ; Ceramics ; Dogs ; Durapatite ; Glass ; Humans ; Hydroxyapatites/therapeutic use ; Male ; Orthodontics ; Rabbits ; Rats ; Rats, Inbred Strains ; Surface Properties ; Tissue Adhesives/therapeutic use
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Frequency-dependent noradrenergic modulation of long-term potentiation in the hippocampus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield. Similar results were obtained with isoproterenol, whereas propranolol or timolol reversibly blocked long-term potentiation. Norepinephrine had little apparent effect on responses obtained during low-frequency stimulation of the mossy fibers. These data suggest that norepinephrine can mediate long-lasting, frequency-dependent modulation of synaptic transmission in the mammalian brain. Furthermore, the results suggest a plausible mechanism for some of the known associative interactions between synaptic inputs to hippocampal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hopkins, W F -- Johnston, D -- NS11535/NS/NINDS NIH HHS/ -- NS15772/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):350-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6091272" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Electric Stimulation ; Evoked Potentials ; Hippocampus/drug effects/*physiology ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Norepinephrine/pharmacology/*physiology ; Propranolol/pharmacology ; Rats ; Rats, Inbred Strains ; Synapses/physiology ; Synaptic Transmission/drug effects ; Timolol/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Increased numbers of thoracic dorsal root axons in rats given antibodies to nerve growth factor (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-03
    Description: Sensory axons were counted in untreated 1-month-old rats and in littermates that were injected with antibodies to nerve growth factor. There were 45 percent more unmyelinated and 17 percent more myelinated axons in dorsal roots of the fifth thoracic spinal segment in treated rats. This suggests that the number of sensory axons can be changed by postnatal inactivation of nerve growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hulsebosch, C E -- Coggeshall, R E -- Perez-Polo, J R -- NS 18707/NS/NINDS NIH HHS/ -- S07-RR05427/RR/NCRR NIH HHS/ -- S07-RR07205/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Aug 3;225(4661):525-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740324" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; *Antibodies ; Antigen-Antibody Complex ; Axons/*physiology/ultrastructure ; Microscopy, Electron ; Myelin Sheath/physiology/ultrastructure ; Nerve Growth Factors/immunology/*physiology ; Rats ; Rats, Inbred Strains ; Spinal Cord/*growth & development/ultrastructure
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  • 20
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    Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-23
    Description: Injections of leupeptin (a thiol proteinase inhibitor) or chloroquine (a general lysosomal enzyme inhibitor) into the brains of young rats induced the formation of lysosome-associated granular aggregates (dense bodies) which closely resembled the ceroid-lipofuscin that accumulates in certain disease states and during aging. The dense material increased in a dose- and time-dependent fashion and was differentially distributed across brain regions and cell types. These observations provide clues to the origins of ceroid-lipofuscin and suggest means for studying the consequences of its accumulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ivy, G O -- Schottler, F -- Wenzel, J -- Baudry, M -- Lynch, G -- AG 00538/AG/NIA NIH HHS/ -- NS 18950/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 23;226(4677):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects/*ultrastructure ; Chloroquine/*pharmacology ; Leupeptins/*pharmacology ; Lysosomes/drug effects/enzymology/*ultrastructure ; Microscopy, Electron ; Oligopeptides/*pharmacology ; Rats ; Rats, Inbred Strains
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
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    A monoclonal antibody to limbic system neurons (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: A monoclonal antibody produced against hippocampal cell membranes labeled the surface of neurons in the rat limbic system. With a few exceptions, all nonlimbic components were unstained. This specific distribution of immunopositive neurons provides strong evidence of molecular specificity among functionally related neurons in the mammalian brain and supports the concept of a limbic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levitt, P -- NS 19606/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6199842" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Axons/immunology ; Brain Stem/immunology ; Cell Membrane/immunology ; Cerebellum/immunology ; Cerebral Cortex/immunology ; Diencephalon/immunology ; Epitopes/*analysis ; Female ; Hippocampus/*immunology ; Hypothalamus/immunology ; Immunoenzyme Techniques ; Limbic System/cytology/*immunology ; Neurons/*immunology ; Rats ; Rats, Inbred Strains ; Spinal Cord/immunology ; Telencephalon/immunology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
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    Separation of morphine analgesia from physical dependence (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-26
    Description: Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ling, G S -- MacLeod, J M -- Lee, S -- Lockhart, S H -- Pasternak, G W -- DA 002615/DA/NIDA NIH HHS/ -- NS 00415/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):462-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6541807" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; Humans ; Male ; Morphine/*pharmacology ; Naloxone/*analogs & derivatives/pharmacology ; Rats ; Rats, Inbred Strains ; Substance Withdrawal Syndrome ; *Substance-Related Disorders
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  • 23
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    High-resolution proton nuclear magnetic resonance analysis of metastatic cancer cells (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-21
    Description: High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane-bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mountford, C E -- Wright, L C -- Holmes, K T -- Mackinnon, W B -- Gregory, P -- Fox, R M -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1415-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505699" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/analysis ; Cholesterol Esters/analysis ; *Magnetic Resonance Spectroscopy ; Membrane Lipids/analysis ; Neoplasm Metastasis/*etiology ; Neoplasms, Experimental/*analysis/pathology ; Rats ; Rats, Inbred Strains ; Triglycerides/analysis
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  • 24
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    Insulin: carrier potential for enzyme and drug therapy (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-23
    Description: Several carrier systems and targeting agents have been considered as means of delivering enzymes and drugs to specific tissues or cells. In this report insulin is shown to be effective in delivering enzyme-albumin conjugates to cells and tissues rich in insulin receptors. The complex is transported into cells by a process that resembles receptor-mediated endocytosis and can be identified in a lysosomal fraction. The enzyme-albumin-insulin complex retains its enzymatic activity and its ability to bind antibodies to insulin. It also has a hypoglycemic effect; however, plasma glucose concentrations can be maintained by glucose administration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poznansky, M J -- Singh, R -- Singh, B -- Fantus, G -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1304-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6367042" target="_blank"〉PubMed〈/a〉
    Keywords: Albumins ; Animals ; Cell Membrane/metabolism ; Chick Embryo ; Chloroquine/pharmacology ; Female ; Glucosidases/*administration & dosage ; Insulin/*metabolism ; Lysosomes/metabolism ; Mice ; Mice, Inbred BALB C ; Muscles ; Rats ; Rats, Inbred Strains ; Receptor, Insulin/metabolism ; Spleen ; Temperature ; alpha-Glucosidases/*administration & dosage/metabolism
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  • 25
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    Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-02
    Description: Localization of [3H]estradiol in tyrosine hydroxylase-containing neurons of rat brain was shown by a combined technique of autoradiography and immunohistochemistry. [3H]Estradiol was concentrated in the nuclei of tyrosine hydroxylase-containing neurons in the nucleus arcuatus, nucleus periventricularis hypothalami, and the zona incerta. These results suggest that estradiol acts directly on dopamine-producing neurons of the tuberoinfundibular system and incertohypothalamic system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sar, M -- NS 00914/NS/NINDS NIH HHS/ -- NS 17479/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 2;223(4639):938-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6141639" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arcuate Nucleus of Hypothalamus/analysis/enzymology ; Cell Nucleus/analysis ; Estradiol/*analysis ; Female ; Hypothalamus/*analysis/enzymology ; Neurons/*analysis/enzymology ; Paraventricular Hypothalamic Nucleus/analysis/enzymology ; Rats ; Rats, Inbred Strains ; Tyrosine 3-Monooxygenase/*metabolism
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  • 26
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    Endogenous opiates and stress-induced eating (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Antelman, S M -- Rowland, N -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1149-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302588" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Endorphins/*physiology ; Feeding Behavior/drug effects/*physiology ; Humans ; Naloxone/pharmacology ; Rats ; Rats, Inbred Strains ; Stress, Psychological/*physiopathology
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  • 27
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    Reduction in oocyte number following prenatal exposure to a diet high in galactose (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-04
    Description: When pregnant rats were fed a 50 percent galactose diet there was a striking reduction in oocyte number in the offspring. The most prominent effects were noted after exposure to galactose during the premeiotic stages of oogenesis. Prenatal exposure to galactose or its metabolites may contribute to the premature ovarian failure characteristic of human galactosemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Y T -- Mattison, D R -- Feigenbaum, L -- Fukui, H -- Schulman, J D -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1145-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302587" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dietary Carbohydrates/*physiology ; Female ; Fetus/drug effects/physiology ; Galactose/*pharmacology ; Maternal-Fetal Exchange ; Oocytes/drug effects/*physiology ; Ovum/*physiology ; Pregnancy ; Rats ; Rats, Inbred Strains
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  • 28
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    Detection of circulating metallothionein in rats injected with zinc or cadmium (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-13
    Description: Circulating metallothionein was measured by radioimmunoassay over a 13-day period in male Sprague-Dawley rats that received a sequence of three intraperitoneal injections (at 3-day intervals) of either 5 milligrams of zinc or 0.8 milligrams of cadmium per kilogram of body weight. These amounts of zinc and cadmium produced metallothionein concentrations in the range of 2 to 5 nanograms per milliliter of serum (zinc) and 2 to 15 nanograms per milliliter of serum (cadmium). In control rats given saline injections over the same period the metallothionein concentration ranged from 1 to 3 nanograms per milliliter of serum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garvey, J S -- Chang, C C -- ES 01629/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1981 Nov 13;214(4522):805-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292012" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cadmium/*pharmacology ; Dose-Response Relationship, Drug ; Male ; Metalloproteins/*blood ; Metallothionein/*blood/immunology ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Zinc/*pharmacology
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  • 29
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    Brain aging correlates: retardation by hormonal-pharmacological treatments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-30
    Description: Mid-aged rats were either adrenalectomized and chronically maintained, or left intact and treated daily for a 9- to 10-month period with a potent analog of the peptide adrenocorticotropin (residues 4 to 9), which has some stimulant properties, or with the neural stimulant pentylenetetrazole. All three treatments reduced hippocampal morphologic correlates of brain aging (neuronal loss, glial reactivity). The pentylenetetrazole and peptide treatments also improved reversal learning. These results suggest that certain endogenous peptides, with stimulant properties, may also exert long-term, trophic effects on brain structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landfield, P W -- Baskin, R K -- Pitler, T A -- AG 01552/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):581-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270791" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenalectomy ; Adrenocorticotropic Hormone/*pharmacology ; *Aging ; Animals ; Brain/*physiology ; Hippocampus/cytology/physiology ; Learning/physiology ; Pentylenetetrazole/*pharmacology ; Peptide Fragments/*pharmacology ; Rats ; Rats, Inbred Strains
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  • 30
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    Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-20
    Description: The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, R A -- Miller, L P -- Lovenberg, W -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):919-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117945" target="_blank"〉PubMed〈/a〉
    Keywords: Aminohydrolases/*metabolism ; Animals ; Biopterin/analogs & derivatives/*metabolism ; Corpus Striatum/drug effects/*metabolism ; Dopamine/*metabolism ; GTP Cyclohydrolase/*metabolism ; Hydroxydopamines/pharmacology ; Male ; Pteridines/*metabolism ; Rats ; Rats, Inbred Strains ; Substantia Nigra/drug effects/metabolism ; Tyrosine 3-Monooxygenase/*metabolism
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  • 31
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    Dopamine receptor binding is increased in diabetic rats (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-11-27
    Description: The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lozovsky, D -- Saller, C F -- Kopin, I J -- New York, N.Y. -- Science. 1981 Nov 27;214(4524):1031-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6458088" target="_blank"〉PubMed〈/a〉
    Keywords: Alloxan/pharmacology ; Animals ; Blood Glucose/metabolism ; Cell Membrane/metabolism ; Corpus Striatum/*metabolism ; Diabetes Mellitus, Experimental/drug therapy/*metabolism ; Insulin/therapeutic use ; Kinetics ; Male ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/drug effects/*metabolism ; Spiperone/metabolism ; Streptozocin/pharmacology
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  • 32
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    Hypothyroidism elicits electrophysiological noradrenergic subsensitivity in rat cerebellum (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: discharge rats of Purkinje neurons were compared in control and hypothyroid adult rats. Purkinje neurons in hypothyroid rats fired significantly faster and were less sensitive to iontophoretically applied norepinephrine than those in control rats. The subsensitivity of the Purkinje neurons appeared to be primarily due to an alteration in the beta-receptor--adenylate cyclase complex, because the sensitivity of these cells to locally applied N6-monobutyryl adenosine 3'-5'-monophosphate (N6 cyclic AMP) did not change significantly. The sensitivity of the Purkinje neurons to norepinephrine could be restored in hypothyroid rats by administration of triiodothyronine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marwaha, J -- Prasad, K N -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):675-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6270792" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Adenylyl Cyclases/metabolism ; Adrenergic Fibers/*physiopathology ; Animals ; Cerebellum/*physiopathology ; Cyclic AMP/metabolism ; Hypothyroidism/*physiopathology ; Male ; Norepinephrine/*physiology ; Purkinje Fibers/physiopathology ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic/*physiology ; Receptors, Adrenergic, beta/*physiology ; Triiodothyronine/*pharmacology
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    DNA synthesis in cultured adult cardiocytes (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-30
    Description: Trypsin-dissociated atrial cardiocytes from adult rats were exposed to [3H]thymidine for sequential 24-hour periods from day 2 to day 12 of culture. On day 3 and each day thereafter, cells were prepared for ultrastructural radioautography and examined with an electron microscope. Maximal incorporation occurred on day 5, when 63 percent of the cardiocytes were labeled. Mitotic activity was never present in more than 0.5 percent of the cardiocytes examined. Incorporation of [3H]thymidine and mitosis occurred only in immature cardiocytes characterized by subsarcolemmal primary filaments and Z bands with or without specific granules; more mature cardiocytes were never labeled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantin, M -- Ballak, M -- Beuzeron-Mangina, J -- Anand-Srivastava, M B -- Tautu, C -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):569-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; Female ; Mitosis ; Myocardium/*cytology ; Rats ; Rats, Inbred Strains ; Time Factors
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  • 34
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    Neuroleptic drug-induced dopamine receptor supersensitivity: antagonism by L-prolyl-L-leucyl-glycinamide (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-11
    Description: An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible functional coupling of the putative PLG receptor with neuroleptic-dopamine receptor complex and clinical implications for tardive dyskinesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chiu, S -- Paulose, C S -- Mishra, R K -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1261-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117947" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Butyrophenones/*metabolism ; Chlorpromazine/*pharmacology ; Corpus Striatum/*metabolism ; Haloperidol/*pharmacology ; Kinetics ; MSH Release-Inhibiting Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine/drug effects/*metabolism ; Spiperone/*metabolism
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    Cerebral cortex responds rapidly to thyroid hormones (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: In rats subjected to thyroidectomy there was a two- to fourfold increase in cerebral cortex iodothyronine 5'-deiodinase activity within 24 hours. This increase was prevented by thyroxine replacement. The increased cortical 5'-deiodinase in chronically hypothyroid rats was normalized within 4 hours by a single intravenous injection of triiodothyronine. These results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leonard, J L -- Kaplan, M M -- Visser, T J -- Silva, J E -- Larsen, P R -- AM00727/AM/NIADDK NIH HHS/ -- AM18616/AM/NIADDK NIH HHS/ -- AM25340/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):571-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291997" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*enzymology ; Iodide Peroxidase/*metabolism ; Liver/metabolism ; Male ; Peroxidases/*metabolism ; Rats ; Rats, Inbred Strains ; Thyroidectomy ; Thyroxine/*metabolism ; Time Factors ; Triiodothyronine/*metabolism ; Triiodothyronine, Reverse/metabolism
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  • 36
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    Intraventricular calcitonin inhibits gastric acid secretion (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-11-06
    Description: Parenteral and intracerebroventricular administration of calcitonin in rats resulted in the suppression of gastric acid secretion. This suppression also occurred in rats with insulin-induced hypoglycemia and after the administration of thyrotropin-releasing hormone. Intracerebroventricularly administered calcitonin was 1000 times more effective than parenterally administered calcitonin in suppressing gastric acid secretion. Calcitonin also inhibited the development of stress-induced ulcers in rats.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morley, J E -- Levine, A S -- Silvis, S E -- New York, N.Y. -- Science. 1981 Nov 6;214(4521):671-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7292006" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*drug effects ; Calcitonin/administration & dosage/*pharmacology ; Gastric Juice/*secretion ; Injections, Intraventricular ; Male ; Peptic Ulcer/etiology ; Rats ; Rats, Inbred Strains ; Stress, Physiological/complications
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    Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-10-30
    Description: Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollard, M -- Luckert, P H -- CA 00295/CA/NCI NIH HHS/ -- CA 15957/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):558-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dimethylnitrosamine/*analogs & derivatives/antagonists & inhibitors ; Indomethacin/*pharmacology ; Intestinal Neoplasms/*chemically induced ; Male ; Neoplasms, Experimental/chemically induced ; Rats ; Rats, Inbred Strains ; Species Specificity
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  • 38
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    Trauma-induced protein in rat tissues: a physiological role for a "heat shock" protein? (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-02
    Description: Hyperthermic shock induces the synthesis of a novel protein (P71) in many rat tissues in vivo. In incubated rat tissue slices P71 is the major protein synthesized even though it is undetectable in the tissues of a normal, unstressed rat. P71 is "heat shock" protein, and it may be induced in vivo by stimuli other than hyperthermia. These results indicate that caution must be used in studies of protein synthesis in tissue explants, since the pattern of proteins synthesized by rat tissue slices is characteristic of stressed tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Currie, R W -- White, F P -- New York, N.Y. -- Science. 1981 Oct 2;214(4516):72-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280681" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Heat-Shock Proteins ; *Hot Temperature ; Isoelectric Point ; Male ; Molecular Weight ; Myocardium/metabolism ; *Protein Biosynthesis ; Rats ; Rats, Inbred Strains ; Stress, Physiological/*metabolism ; Tissue Distribution
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  • 39
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    Intestinal diffusion barrier: unstirred water layer or membrane surface mucous coat? (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-11
    Description: The dimensions of the small intestinal diffusion barrier interposed between luminal nutrients and their membrane receptors were determined from kinetic analysis of substrate hydrolysis by integral surface membrane enzymes. The calculated equivalent thickness of the unstirred water layer was too large to be compatible with the known dimensions of rat intestine. The discrepancy could be reconciled by consideration of the mucous coat overlying the intestinal surface membrane. Integral surface membrane proteins could not be labeled by an iodine-125 probe unless the surface coat was first removed. The mucoprotein surface coat appears to constitute an important diffusion barrier for nutrients seeking their digestive and transport sites on the outer intestinal membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithson, K W -- Millar, D B -- Jacobs, L R -- Gray, G M -- AM 05418/AM/NIADDK NIH HHS/ -- AM 11270/AM/NIADDK NIH HHS/ -- AM 15802/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1241-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7302593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/*metabolism ; Diffusion ; Disaccharides/metabolism ; *Intestinal Absorption ; Jejunum/*metabolism/ultrastructure ; Kinetics ; Male ; Microscopy, Electron ; Microvilli/*metabolism/ultrastructure ; Rats ; Rats, Inbred Strains
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    Epinephrine enables Pavlovian fear conditioning under anesthesia (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-02-10
    Description: Rats under Pavlovian defensive conditioning (noise paired with shock) while under general anesthesia. Peripheral administration of epinephrine (0.01 to 1.0 milligram per kilogram of body weight) during training resulted in the acquisition of conditioned fear, as shown 10 days later by conditioned suppression of water drinking. Analysis of heart rate and measurement of reflexes during training indicated that epinephrine did not lighten the state of anesthesia. These results indicate that epinephrine enables the learning of conditioned fear in the anesthetized brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberger, N M -- Gold, P E -- Sternberg, D B -- AL 01642/PHS HHS/ -- MH 12526/MH/NIMH NIH HHS/ -- MH 31144/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):605-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695173" target="_blank"〉PubMed〈/a〉
    Keywords: *Anesthesia, General ; Animals ; Chloral Hydrate ; Conditioning (Psychology)/*drug effects ; Epinephrine/*pharmacology ; Fear ; Male ; Pentobarbital ; Rats ; Rats, Inbred Strains ; *Reinforcement (Psychology)
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    Growth hormone-releasing factor: direct effects on growth hormone, glucose, and behavior via the brain (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-10-26
    Description: Intracerebroventricular administration of human pancreatic growth hormone-releasing factor caused a dose-dependent inhibition of growth hormone secretion, elevated plasma glucose concentrations, and produced marked behavioral and motor effects. Immunoneutralization with antiserum to somatostatin did not reverse the suppression of growth hormone. These findings suggest that hypothalamic growth hormone-releasing factor may regulate its own neurosecretion through an "ultrashort-loop" negative feedback mechanism and may have important neurotransmitter and neuromodulatory functions in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, G S -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):464-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6436973" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; *Blood Glucose ; Dose-Response Relationship, Drug ; Feedback ; Growth Hormone/*secretion ; Growth Hormone-Releasing Hormone/*pharmacology ; Male ; Rats ; Rats, Inbred Strains
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  • 42
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    Intestinal uptake and metabolism of auranofin, a new oral gold-based antiarthritis drug (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-07-27
    Description: Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-(triethy lphosphine)- gold(I), an experimental antiarthritis pharmaceutical, metabolized in contact with hamster or rat gut wall to yield the deacetylated form of the drug. This product, 1-thio-beta-D-glucopyranosato-S-(triethylphosphine)gold(I), passed through hamster or rat intestinal wall in an everted gut experiment. The metabolite was separated by high-performance liquid chromatography and characterized by retention time, chemical reactivity to yield a known product, and comparison to a synthetic sample of the metabolite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tepperman, K -- Finer, R -- Donovan, S -- Elder, R C -- Doi, J -- Ratliff, D -- Ng, K -- New York, N.Y. -- Science. 1984 Jul 27;225(4660):430-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6429854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Inflammatory Agents/*metabolism ; Auranofin ; Aurothioglucose/*analogs & derivatives/metabolism ; Chromatography, High Pressure Liquid ; Cricetinae ; Gold/*analogs & derivatives ; *Intestinal Absorption ; Mesocricetus ; Rats ; Rats, Inbred Strains
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    Decreased oxidation of labeled glucose by dissociated brain cells in the presence of fetal bovine serum (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-05-25
    Description: The effect of serum on the rate of substrate oxidation by dissociated brain cells in vitro was examined. At a serum protein concentration of approximately 0.55 milligram per milliliter, oxidation of [6-14C]glucose to 14CO2 was decreased more than 50 percent. Oxidation of [3-14C]-3-hydroxybutyrate and [U-14C]glutamine was decreased much less. Serum from cows, rats, horses, and humans produced similar effects, as did serum from young and old animals and from both sexes. The effect on [6-14C]glucose oxidation was proportional to serum protein concentration, and significant inhibitory activity was obtained with dialyzed serum. Heating (80 degrees C for 10 minutes) significantly reduced the inhibitory activity. These results suggest the presence of a factor in serum that can preferentially decrease glucose oxidation. Such a factor would have profound implications for metabolic regulation in vivo and for studies of cells in vitro in which serum is included in the growth medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tildon, J T -- Stevenson, J H -- New York, N.Y. -- Science. 1984 May 25;224(4651):903-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6719124" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood ; Brain/*metabolism ; Cells, Cultured ; *Culture Media ; Glucose/*metabolism ; Glutamine/metabolism ; Hydroxybutyrates/metabolism ; Oxidation-Reduction ; Rats ; Rats, Inbred Strains
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  • 44
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    Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-07-06
    Description: An ethanol-preferring line of rats, developed by selective breeding, consumed as much as 9.4 +/- 1.7 grams of ethanol per kilogram of body weight per day through intragastric self-infusions, yielding blood ethanol concentrations of 92 to 415 milligrams per 100 milliliters. By contrast, the ethanol- nonpreferring line self-administered only 0.7 +/- 0.2 gram per kilogram per day. These findings indicate that the reinforcing effect of ethanol is postabsorptive and is not mediated by the drug's smell or taste. Hence the ethanol-preferring line of rats may be suitable animal model of alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waller, M B -- McBride, W J -- Gatto, G J -- Lumeng, L -- Li, T K -- AA-03243/AA/NIAAA NIH HHS/ -- MH-00203/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Jul 6;225(4657):78-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6539502" target="_blank"〉PubMed〈/a〉
    Keywords: Alcohol Drinking ; Alcoholism/*physiopathology ; Animals ; Disease Models, Animal ; Ethanol/*administration & dosage/blood/metabolism ; Humans ; Male ; Rats ; Rats, Inbred Strains ; Reinforcement (Psychology) ; Stomach/metabolism
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    Salt-sensitive hypertension: contribution of chloride (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-03-30
    Description: The effect of the anion associated with sodium loading on the development of hypertension in the Dahl salt-sensitive rat was determined. For 5 weeks rats were fed a diet containing normal or high concentrations of sodium chloride or high concentrations of sodium provided as a mixture of sodium bicarbonate, phosphate, and amino acids. After 1 week on these diets and until the end of the study the rats receiving high concentrations of sodium chloride had higher systolic blood pressures than the rats in the other two groups. There were no statistically significant group differences in plasma volume, arterial pH, or plasma concentrations of Na+, K+, Cl-, Ca2+, or creatinine, or in renomedullary prostaglandin E2 production. Compared to the animals receiving normal concentrations of sodium chloride, those receiving high concentrations of sodium chloride or amino acids showed decreased plasma renin activity and plasma aldosterone concentrations. Thus, the anion ingested with sodium alters the development and severity of hypertension in the Dahl salt-sensitive rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitescarver, S A -- Ott, C E -- Jackson, B A -- Guthrie, G P Jr -- Kotchen, T A -- AM-32395/AM/NIADDK NIH HHS/ -- HL-00941/HL/NHLBI NIH HHS/ -- HL-22390/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 30;223(4643):1430-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322303" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicarbonates/adverse effects ; Blood Pressure/drug effects ; Chlorides/*adverse effects ; Diet ; Hypertension/*chemically induced ; Kidney/physiopathology ; Loop of Henle/physiopathology ; Male ; Phosphates/adverse effects ; Rats ; Rats, Inbred Strains ; Sodium Bicarbonate ; Sodium Chloride/adverse effects
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    GM1 ganglioside treatment facilitates behavioral recovery from bilateral brain damage (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-07-20
    Description: Adult rats with bilateral lesions of the caudate nucleus were treated with GM1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabel, B A -- Slavin, M D -- Stein, D G -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):340-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6740316" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Brain Injuries/*drug therapy/psychology ; Caudate Nucleus/drug effects/injuries ; G(M1) Ganglioside/pharmacology/*therapeutic use ; Gangliosides/*therapeutic use ; Humans ; Learning/drug effects ; Male ; Rats ; Rats, Inbred Strains
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    A conformationally constrained vasopressin analog with antidiuretic antagonistic activity (1984)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1984-10-26
    Description: Application of information derived from a three-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a bicyclic vasopressin analog, [5,8-cyclo(1-beta-mercaptopropionic acid,2-phenylalanine,5-aspartic acid,8-lysine)]vasopressin. The analog acts as an antagonist of the antidiuretic activity of vasopressin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skala, G -- Smith, C W -- Taylor, C J -- Ludens, J H -- New York, N.Y. -- Science. 1984 Oct 26;226(4673):443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6541806" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arginine Vasopressin/*analogs & derivatives ; Lypressin/*analogs & derivatives ; Male ; Rats ; Rats, Inbred Strains ; Structure-Activity Relationship
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 48
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    Metabolic mapping of the brain during rewarding self-stimulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-20
    Description: Local rates of cerebral glucose utilization were measured in rats by the quantitative 2-deoxy-D-[14C]glucose autoradiographic method during electrical stimulation of the ventral tegmental area. Rats trained in intracranial self-stimulation showed a pattern of changes in forebrain metabolic activity distinctly different from the pattern seen in rats stimulated by the experimenter. These findings provide information about the distribution of local cerebral activity specific to reinforced instrumental behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porrino, L J -- Esposito, R U -- Seeger, T F -- Crane, A M -- Pert, A -- Sokoloff, L -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):306-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710145" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Behavior, Animal ; Brain/*metabolism ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Diencephalon/metabolism ; Electric Stimulation ; Male ; Rats ; Rats, Inbred Strains ; Reinforcement (Psychology) ; *Reward ; Self Stimulation/*physiology ; Telencephalon/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 49
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    Spinal sympathetic pathway: an enkephalin ladder (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-17
    Description: Enkephalin distribution was examined in autonomic areas of the rat thoracic spinal cord. The localization of enkephalin fibers coincided with nuclear regions containing sympathetic preganglionic neurons. Horizontal sections revealed a pattern for enkephalin fibers resembling Laruelle's description of the localization of sympathetic preganglionic neurons as rungs of a ladder.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romagnano, M A -- Hamill, R W -- New York, N.Y. -- Science. 1984 Aug 17;225(4663):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6463650" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autonomic Fibers, Preganglionic/physiology ; Cats ; Colchicine ; Enkephalins/*physiology ; Female ; Male ; Rats ; Rats, Inbred Strains ; Spinal Cord/*physiology ; Sympathetic Nervous System/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 50
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    Receptor binding studies (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siiteri, P K -- New York, N.Y. -- Science. 1984 Jan 13;223(4632):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318319" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Female ; Hormones/*metabolism ; *Radioligand Assay ; Rats ; Rats, Inbred Strains ; Receptors, Cell Surface/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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