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  • 1
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    Equitable allocations in northern fisheries: bridging the divide for Labrador Inuit (2021)
    Frontiers Media
    Details
    Publication Date: 2022-10-26
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kourantidou, M., Hoagland, P., Dale, A., & Bailey, M. Equitable allocations in northern fisheries: bridging the divide for Labrador Inuit. Frontiers in Marine Science, 8, (2021): 590213, https://doi.org/10.3389/fmars.2021.590213.
    Description: Canada has undertaken commitments to recognize the rights of Indigenous Peoples in fisheries through policies and agreements, including Integrated Fishery Management Plans, the Reconciliation Strategy, and Land Claim Agreements (LCAs). In addition to recognizing rights, these commitments were intended to respect geographic adjacency principles, to enhance the economic viability of Indigenous communities, and to be reflective of community dependence on marine resources. We examined the determinants of quota allocations in commercial fisheries involving Nunatsiavut, Northern Labrador, the first self-governing region for the Inuit peoples in Canada. It has been argued that current fishery allocations for Nunatsiavut Inuit have not satisfied federal commitments to recognize Indigenous rights. Indicators that measure equity in commercial allocations for the turbot or Greenland halibut (Reinhardtius hippoglossoides) and northern shrimp (Pandalus borealis) fisheries were identified and assessed. In these two cases, historical allocations continue to predominate for allocations based upon equity or other social or economic considerations. We illustrate equity-enhancing changes in the quota distribution under scenarios of different levels of inequality aversion, and we make qualitative assessments of the effects of these allocations to Nunatsiavut for socioeconomic welfare. This approach could benefit fisheries governance in Northern Labrador, where federal commitments to equity objectives continue to be endorsed but have not yet been integrated fully into quota allocations.
    Description: This research was undertaken with funding from the Canada First Research Excellence Fund through the Ocean Frontier Institute (MK and MB) and the Johnson Endowment of the Woods Hole Oceanographic Institution’s (WHOI) Marine Policy Center (PH).
    Keywords: Fisheries ; Allocations ; Equity ; Indigenous rights ; Access
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
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    Experiments on the induced spawning and larval rearing of the milkfish, Chanos chanos (Forsskal) in 1979 (2021)
    In:  aqdchief@seafdec.org.ph | http://aquaticcommons.org/id/eprint/18569 | 2002 | 2015-11-15 16:06:30 | 18569 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Description: This paper summarizes the results of the experiments on the induced breeding and larval rearing of milkfish (Chanos chanos) during the 1979 season. Milkfish larvae could be reared successfully without the use of trochophore larvae of oysters as feed during the first few days. In order to induce the ovulation of wild adult milkfish a higher dose of human chorionic gonadotropin hormone is required.
    Keywords: Fisheries ; Chanos chanos ; ISEW ; Philippines ; marine environment ; Brood stocks ; Fish culture ; Fish larvae ; Food organisms ; Induced breeding ; Larval development ; Sex hormones
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 1-3
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  • 3
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    Knowing Asian aquaculture and fisheries. Part 1 (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20100 | 17342 | 2016-02-24 22:18:26 | 20100 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Description: An outline is given of aquaculture and fisheries in Asia, providing information of use to students whose work can influence laws, rules, policy and regulations on aquaculture and fisheries, with the view in mind to sustainable aquaculture. In this issue, the following countries are examined: China, Indonesia, and Bangladesh.
    Keywords: Aquaculture ; Fisheries ; Fishery management ; Aquaculture development ; Aquaculture regulations ; Marine aquaculture ; Freshwater aquaculture ; Fishery industry ; Asia ; Bangladesh ; China
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 7-8
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  • 4
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    Knowing Asian aquaculture and fisheries. Part 4 (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20067 | 2002 | 2016-03-04 15:16:24 | 20067 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Vietnam ; Sri Lanka ; Sri Lanka ; Vietnam ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture techniques ; Brackishwater aquaculture ; Feed ; Fish culture ; Fish diseases ; Fisheries ; Fishery data ; Food organisms ; Freshwater aquaculture ; Marine aquaculture ; Marine fisheries ; Mollusc culture ; Pond culture ; Seaweed culture ; Shrimp culture
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: pp.9-10, 27
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  • 5
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    Knowing Asian aquaculture and fisheries (2021)
    In:  library@seafdec.org.ph | http://aquaticcommons.org/id/eprint/20055 | 2002 | 2016-03-03 11:33:32 | 20055 | Southeast Asian Fisheries Development Center, Aquaculture Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Aquaculture ; Asia ; Cambodia ; India ; Asia ; Cambodia ; India ; Myanmar ; Myanmar ; brackishwater environment ; freshwater environment ; marine environment ; Aquaculture ; Aquaculture development ; Aquaculture economics ; Aquaculture techniques ; Brackishwater aquaculture ; Catching methods ; Culture effects ; Environmental impact ; Fish culture ; Fisheries ; Fishery development ; Fishery resources ; Fishery statistics ; Freshwater aquaculture ; Marine aquaculture ; Shrimp culture ; Sustainability ; Trade
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: pp.9-10, 29
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  • 6
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    Regional survey of heavy metals in fish and fish products: Indonesia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26291 | 23782 | 2019-04-08 09:42:05 | 26291 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Pollution ; Indonesia ; Heavy metals ; Chemical pollution ; Pollution monitoring
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 10-19
    Format: 10
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  • 7
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    Regional survey of heavy metals in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26293 | 23782 | 2019-03-22 03:49:21 | 26293 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Heavy metals ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 38-46
    Format: 9
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  • 8
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    Round scad exploration by purse seine in the South China Sea, Area III: Western Philippines (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26259 | 2002 | 2019-03-01 05:56:06 | 26259 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: Round scad exploration by purse seine in the waters of western Philippines was conducted from April 22 to May 7, 1998 for a period of five (5) fishing days with a total catch of 7.3 tons and an average of 1.5 tons per setting. Dominant species caught were Decapterus spp. having 70.09% of the total catch, followed by Selar spp. at 12.66% and Rastrelliger spp. 10.70%. Among the Decapterus spp. caught, D. macrosoma attained the highest total catch composition by species having 68.81% followed by D. kurroides and D.russelli with 0.31% and 1.14% respectively. The round scad fishery stock was composed mainly of juvenile fish (less than 13 cm) and Age group II (13 cm to 14 cm). Few large round scad at Age group IV and V (20 cm to 28 cm) stayed at the fishery. Other fishes caught were: Auxis rochei (0.85%), A. thazard (0.12%), Caranx spp. (0.45%), Emmilichthys nitidus (0.58%), Euthynnus affinis (0.42%), Leiognathus ruconius (0.58%), Loligo sp. (0.31%), Megalaspis cordyla (0.09%), Rastrelliger spp. (10.70%), Sardinella longiceps (0.03%), Scomberoides lysan (0.24%), Selar spp. (12.66%), Sphyraena spp. (0.90%), Thunnus albacares (0.96%) and others (1.02%). Tuna and tuna like fishes such as yellowfin tuna, eastern little tuna, bullet tuna, frigate tuna and oceanic squid are distributed in the upper latitudes of the survey area. On the other hand, round scads, big-eyed scads and Indian mackerels are dominantly present in the lower latitudes of the survey area.
    Keywords: Fisheries ; Exploratory fishing ; Purse seining ; Age composition ; Catch composition ; Fishery surveys ; Carangid fisheries ; South China Sea ; Philippines ; Rastrelliger ; Decapterus
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 49-64
    Format: 16
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  • 9
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    Fisheries in Brunei Darussalam (2021)
    Training Department, Southeast Asian Fisheries Development Center | Samut Prakarn, Thailand
    In:  http://aquaticcommons.org/id/eprint/26215 | 17342 | 2019-02-08 06:25:54 | 26215 | Southeast Asian Fisheries Development Center, Training Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in this paper is the status of the fishery industry in Brunei Darussalam. Specifically, it discussed the following topics: fishery management strategies, zonation scheme, licencing, the use of poisons and explosives, the minimum cod-end mesh size for trawlers, closed areas, enhancement of fishing grounds, and the enforcement activities.
    Keywords: Fisheries ; Fishery resources ; Fishery management ; Fisheries ; Ecological zonation ; Licensing ; Fish poisoning ; Catching methods ; Illegal fishing ; Explosive fishing ; Fishing gear ; Season regulations ; Fishing grounds
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 34-40
    Format: 7
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  • 10
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    Regional survey of heavy metals in fish and fish products: Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26295 | 23782 | 2019-03-22 08:39:12 | 26295 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Thailand ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 53-58
    Format: 6
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  • 11
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    Regional survey of heavy metals in fish and fish products: Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26292 | 23782 | 2019-03-22 03:43:09 | 26292 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Malaysia ; Cadmium ; Lead ; Mercury ; Biological sampling ; Fish ; Fishery products ; Seafood
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 20-37
    Format: 18
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  • 12
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    Tuna resource exploration with longline in the South China Sea, Area III: Western Philippines (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26258 | 2002 | 2019-03-01 06:00:19 | 26258 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: An exploratory tuna longline fishing survey was conducted using the research and training vessels of the Southeast Asian Fisheries Development Center, the 1,178 GT MV SEAFDEC and the Bureau of Fisheries and Aquatic Resources, the 165 GT MV MAYA-MAYA in the South China Sea Waters, West of the Philippines from April to May, 1998. A total of 3,796 hooks was set in sixteen (16) fishing stations. There were no tuna caught during the entire survey but only minor and irrelevant species like the Pacific lancetfish, sharks and an opah species, Lampris guttatus. The important fishing and oceanographic factors during the survey and other research results on longline are described and analyzed. Additional longline studies within and near the Philippines territorial waters are also presented to substantiate the research results of the joint SEAFDEC/BFAR resource exploratory.
    Keywords: Fisheries ; Exploratory fishing ; Catch composition ; Fishery surveys ; Longlining ; Tuna fisheries ; South China Sea ; Philippines
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 39-48
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  • 13
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    Regional survey of pesticide residues in fish and fish products: Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26299 | 23782 | 2019-03-27 06:00:01 | 26299 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Malaysia ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Biochemical analysis ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 71-74
    Format: 4
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  • 14
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    Regional survey of pesticide residues in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26300 | 23782 | 2019-03-27 05:58:36 | 26300 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Aquaculture ; Chemistry ; Fisheries ; Myanmar ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 75-83
    Format: 9
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  • 15
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    Regional survey of histamine in fish and fish products: Indonesia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26307 | 23782 | 2019-03-27 03:35:56 | 26307 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Indonesia ; Histamines ; Biological sampling ; Fish ; Fishery products ; Quality control
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 116-123
    Format: 8
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  • 16
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    Regional survey of pesticide residues in fish and fish products: Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26303 | 23782 | 2019-03-27 05:51:15 | 26303 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Chemistry ; Fisheries ; Thailand ; Pesticides ; Biological sampling ; Fish ; Fishery products ; Dried products ; Lethal limits
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 100-105
    Format: 6
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  • 17
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    Regional survey of histamine in fish and fish products: Myanmar (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26309 | 23782 | 2019-03-27 03:49:31 | 26309 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Keywords: Fisheries ; Myanmar ; Histamines ; Biological sampling ; Biochemical analysis ; Fish ; Fishery products
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 129-133
    Format: 5
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  • 18
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    Determination of chemical properties of meat: Determination of K value (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26826 | 23782 | 2019-11-21 00:56:12 | 26826 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the determination of K value which is an index to measure the enzymatic freshness of fish and squid. Specifically, reagents, apparatus and the analytical procedures needed and the calculations are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-6.1-B-6.7
    Format: 7
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  • 19
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    Determination of chemical properties of meat: Freshness testing paper (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26825 | 23782 | 2019-11-21 00:52:35 | 26825 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in measuring K value in fish meat by means of the freshness testing paper technique.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fish inspection ; Fishery industry ; Food technology ; Standards ; Specifications
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: B-7.1-B-7.2
    Format: 2
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  • 20
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    Determination of physical properties of meat: Measurement of pH (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26802 | 23782 | 2019-11-12 05:28:20 | 26802 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: Presented in the paper is the standard procedure in the measurement of pH in the fresh fish meat. Specifically, the procedures in sampling and sample preparation, apparatus and reagents required, and the analytical procedures are presented.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Microbiological analysis ; Fishery products ; Processed fishery products ; Fish inspection ; Fishery industry ; Food additives ; Food technology ; Standards ; Specifications ; pH
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: A-3.1-A-3.2
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  • 21
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    Analysis of additives: Determination of starch (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26842 | 23782 | 2019-11-15 07:54:48 | 26842 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: Starch is commonly used in the production of fish jelly products as an extender and as binding agent. The paper provides the methodology in the determination of starch in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the starch in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Starch ; Additives ; Food additives
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: D-4.1-D-4.4
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  • 22
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    Red tides and paralytic shellfish poisoning in the Philippines (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26881 | 23782 | 2019-11-05 02:46:02 | 26881 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Monitoring and investigative work undertaken in the Philippines regarding dinoflagellate blooms are described. Chronological observations of the occurrence of red tides, aerial surveys, spatial distribution of the dinoflagellate and the physical environment are discussed. Fishing and the examination of gut content of fish and mussels and bioassay tests are detailed. Incidents of paralytic shellfish poisoning in the Philippines are considered briefly.
    Keywords: Fisheries ; Health ; Environmental monitoring ; Red tides ; Public health ; Medicine ; Dangerous organisms ; Philippines
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 52-79
    Format: 28
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  • 23
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    Red tide and paralytic shellfish poisoning phenomena in Thailand (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26885 | 23782 | 2019-11-05 02:23:34 | 26885 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: A report is made of the first incidence occurring of paralytic shellfish poisoning in Thailand in May 1983, following an extensive bloom of Trichodesmium erythraeum. Investigations undertaken regarding the source of the toxicity are outlined.
    Keywords: Fisheries ; Health ; Biological poisons ; Public health ; Red tides ; Shellfish ; Dangerous organisms ; Thailand
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 90-91
    Format: 2
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  • 24
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    Red tide and paralytic shellfish poisoning in Sabah, Malaysia (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26879 | 23782 | 2019-11-05 02:54:38 | 26879 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: A brief account is given of recent cases of paralytic shellfish poisoning in Sabah, Malaysia, and toxicological studies undertaken. Hydrography surveys, underwater observations after the occurrence of the red tides and plankton studies and monitoring of red tides are discussed.
    Keywords: Fisheries ; Health ; Shellfish ; Toxicity tests ; Red tides ; Public health ; Dangerous organisms ; Malaysia
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: 35-42
    Format: 8
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  • 25
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    Microbiological procedure: Vibrio cholera (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26852 | 23782 | 2019-11-15 07:36:44 | 26852 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
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    Publication Date: 2022-08-02
    Description: Cholera is an acute specific infection caused by the organism, Vibrio cholera. Diagnosis may be confirmed by the presence of large numbers of the comma-shaped bacilli on direct microscopic examination of a fecal or vomitus smear, and by the isolation of the organism on culture. Fish and shellfish have been identified as vehicles of cholera. Large numbers of V. cholera must usually be ingested to cause cholera. Thus problems often occur when poor handling and inadequate refrigeration have allowed the organism to multiply. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio cholerae
    Repository Name: AquaDocs
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    Format: application/pdf
    Format: application/pdf
    Format: E-7.1-E-7.5
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  • 26
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    Fisheries statistics in Brunei Darussalam (2021)
    Secretariat, Southeast Asian Fisheries Development Center | Bangkok, Thailand
    In:  http://aquaticcommons.org/id/eprint/26890 | 23782 | 2019-11-14 01:01:29 | 26890 | Southeast Asian Fisheries Development Center, Secretariat
    Details
    Publication Date: 2022-08-02
    Description: Fishery statistics in Brunei Darussalam have been collected by the Department of Fisheries since the 1940s. In the early 1980s, a number of statistics were collected, such as catch and effort data of artisanal fishermen, aquaculture statistics, processing statistics as well as data from major wet markets focusing on the amount, prices of marketed fish either from the local fishermen or imported. In 1984, the collection of statistics on commercial fishing was started. The statistics have been used in the formulation of fishery management and development policies as well as for sectoral development. Following a brief account of the responsibility and statistic collections of the Department of Fisheries, an examination is made of employment in the fishery sector, fisheries production, fish marketed and the GDP for the fishery industry. Fisheries in Brunei Darussalam is a very healthy industry, where production is well below the maximum allowable harvestable limit of 20,000 tons at 30%. The Department is embarking to increase production from the capture fishery to reduce the country's dependence on imported fish; the same applies for aquaculture, in order to complement production from the capture fisheries. The processing sector is also increasing in importance, especially with the increase in the number of capture fishery licenses, and the demand for quality and value-added products.
    Keywords: Fisheries ; Marine fisheries ; Fishery statistics ; Aquaculture development ; Aquaculture statistics ; Fish catch statistics ; Marine aquaculture ; Freshwater aquaculture ; Fishery development ; Marine ; Brackish ; Freshwater
    Repository Name: AquaDocs
    Type: book_section
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    Format: application/pdf
    Format: 6-14
    Format: 9
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    Analysis of additives: Determination of salt (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26843 | 23782 | 2019-11-15 07:52:55 | 26843 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Sodium chloride is an important additive for the production of fish jelly products. It extracts the salt soluble protein to give the gel strength of the final product. The paper provides the methodology in the determination of the amount of sodium chloride in fish jelly products. Instructions for sample preparation and the reagents needed are presented. Detailed procedures in the determination of the salt in a sample are provided.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Chemical analysis ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Additives ; Food additives ; Salts ; Sodium chloride
    Repository Name: AquaDocs
    Type: book_section
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    Format: application/pdf
    Format: D-5.1-D-5.2
    Format: 2
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    Microbiological procedure: Vibrio parahaemolyticus (2021)
    Marine Fisheries Research Department, Southeast Asian Fisheries Development Center | Singapore
    In:  http://aquaticcommons.org/id/eprint/26851 | 23782 | 2019-11-14 01:29:31 | 26851 | Southeast Asian Fisheries Development Center, Marine Fisheries Research Department
    Details
    Publication Date: 2022-08-02
    Description: Food poisoning due to Vibrio parahaemolyticus is a food-borne infection resulting from the ingestion of a large number of this organism (about 106-109 viable cells). The major symptoms are diarrhea and abdominal pain with headache, fever, and vomiting also occurring. The organisms are excreted during the acute stage of the illness after which they decrease rapidly. The differentiation of V. parahaemolyticus from other pathogenic species of Vibrio is based mainly on salt tolerance, Voges-Proskauer reaction, fermentation of sucrose, and growth at 43°C. Presented in the paper is the methodology of determining the presence of Vibrio cholera in fish and fishery products.
    Keywords: Chemistry ; Fisheries ; Manuals ; Culture media ; Analysis ; Analytical techniques ; Methodology ; Fishery products ; Fishery industry ; Food technology ; Standards ; Specifications ; Aerobic bacteria ; Microbiological analysis ; Microorganisms ; Pathogenic bacteria ; Pathogens ; Health and safety ; Public health ; Microbial contamination ; Vibrio parahaemolyticus ; Vibrio cholerae
    Repository Name: AquaDocs
    Type: book_section
    Format: application/pdf
    Format: application/pdf
    Format: E-8.1-E-8.6
    Format: 6
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    Magnetic field-cancer link: will it rest in peace? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):29.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9229766" target="_blank"〉PubMed〈/a〉
    Keywords: Case-Control Studies ; Child ; *Electric Wiring ; Electromagnetic Fields/*adverse effects ; Humans ; Leukemia, Radiation-Induced/*etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*etiology ; Radiation Dosage ; Risk Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Scientists probe feelings behind decision-making (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1269.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064783" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Damage, Chronic/physiopathology/*psychology ; *Decision Making ; *Emotions ; Gambling/psychology ; Humans ; *Intuition ; Prefrontal Cortex/*physiology/physiopathology ; Unconscious (Psychology)
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    STATs and gene regulation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-12
    Description: STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Darnell, J E Jr -- AI32489/AI/NIAID NIH HHS/ -- AI34420/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1630-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287210" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/*metabolism ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Dimerization ; *Gene Expression Regulation ; Humans ; Nuclear Proteins/metabolism ; Phosphorylation ; Phosphotyrosine/metabolism ; *Signal Transduction ; Trans-Activators/chemistry/genetics/*metabolism ; *Transcriptional Activation ; src Homology Domains
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Firefly gene lights up lab animals from inside out (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1993.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Recombinant ; Diagnostic Imaging/*methods ; *Gene Expression Regulation ; Genetic Therapy ; HIV/physiology ; HIV Infections/virology ; Luciferases/*genetics ; Luminescence ; Mice ; Mice, Transgenic ; Salmonella Infections, Animal/drug therapy/microbiology ; Virus Replication
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Acquiring language (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pinker, S -- New York, N.Y. -- Science. 1997 May 23;276(5316):1178; author reply 1180-1, 1276.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182320" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Language Development ; *Learning ; Vocabulary
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chow, C W -- Rincon, M -- Cavanagh, J -- Dickens, M -- Davis, R J -- CA58396/CA/NCI NIH HHS/ -- CA65831/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1638-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374467" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; COS Cells ; Calcineurin/metabolism ; Calcineurin Inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/*metabolism ; Cell Line ; Cell Nucleus/*metabolism ; Cyclosporine/pharmacology ; Cytoplasm/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Humans ; JNK Mitogen-Activated Protein Kinases ; Jurkat Cells ; Mitogen-Activated Protein Kinase Kinases ; *Mitogen-Activated Protein Kinases ; Mutation ; NFATC Transcription Factors ; *Nuclear Proteins ; Phosphorylation ; Protein Kinases/metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; T-Lymphocytes/metabolism ; Transcription Factors/genetics/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Initial genetic characterization of the 1918 "Spanish" influenza virus (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: The "Spanish" influenza pandemic killed at least 20 million people in 1918-1919, making it the worst infectious pandemic in history. Understanding the origins of the 1918 virus and the basis for its exceptional virulence may aid in the prediction of future influenza pandemics. RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase, nucleoprotein, matrix protein 1, and matrix protein 2. The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubenberger, J K -- Reid, A H -- Krafft, A E -- Bijwaard, K E -- Fanning, T G -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1793-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington DC 20306-6000, USA. taubenbe@email.afip.osd.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9065404" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Base Sequence ; *Genes, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; History, 20th Century ; Humans ; Influenza A virus/classification/*genetics/pathogenicity ; Influenza, Human/history/*virology ; Lung/virology ; Molecular Sequence Data ; Neuraminidase/genetics ; Nucleoproteins/genetics ; Phylogeny ; Polymerase Chain Reaction ; RNA, Viral/*genetics ; *RNA-Binding Proteins ; Viral Core Proteins/genetics ; Viral Matrix Proteins/genetics ; Virulence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Independent photoreceptive circadian clocks throughout Drosophila (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: Transgenic Drosophila that expressed either luciferase or green fluorescent protein driven from the promoter of the clock gene period were used to monitor the circadian clock in explanted head, thorax, and abdominal tissues. The tissues (including sensory bristles in the leg and wing) showed rhythmic bioluminescence, and the rhythms could be reset by light. The photoreceptive properties of the explanted tissues indicate that unidentified photoreceptors are likely to contribute to photic signal transduction to the clock. These results show that autonomous circadian oscillators are present throughout the body, and they suggest that individual cells in Drosophila are capable of supporting their own independent clocks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plautz, J D -- Kaneko, M -- Hall, J C -- Kay, S A -- MH-51573/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1632-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology and National Science Foundation Center for Biological Timing, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified ; Biological Clocks/*physiology ; Brain/physiology ; Chemoreceptor Cells/physiology ; Circadian Rhythm/*physiology ; Darkness ; Drosophila/genetics/*physiology ; Drosophila Proteins ; Gene Expression Regulation ; Genes, Insect ; Green Fluorescent Proteins ; Light ; Light Signal Transduction ; Luciferases/genetics ; Luminescence ; Luminescent Proteins/genetics ; Nuclear Proteins/genetics/*physiology ; Period Circadian Proteins ; Photoreceptor Cells, Invertebrate/*physiology ; Promoter Regions, Genetic ; Receptors, Cell Surface ; Recombinant Fusion Proteins
    Print ISSN: 0036-8075
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    Requirement of the DEAD-Box protein ded1p for messenger RNA translation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-07
    Description: The DED1 gene, which encodes a putative RNA helicase, has been implicated in nuclear pre-messenger RNA splicing in the yeast Saccharomyces cerevisiae. It is shown here by genetic and biochemical analysis that translation, rather than splicing, is severely impaired in two newly isolated ded1 conditional mutants. Preliminary evidence suggests that the protein Ded1p may be required for the initiation step of translation, as is the distinct DEAD-box protein, eukaryotic initiation factor 4A (eIF4A). The DED1 gene could be functionally replaced by a mouse homolog, PL10, which suggests that the function of Ded1p in translation is evolutionarily conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chuang, R Y -- Weaver, P L -- Liu, Z -- Chang, T H -- GM48752/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 7;275(5305):1468-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular, Cellular, and Developmental Biology Program, Ohio State University, Columbus, OH 43210, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9045610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytoplasm/metabolism ; DEAD-box RNA Helicases ; Eukaryotic Initiation Factor-4A ; Genes, Fungal ; Mice ; Mutation ; Peptide Initiation Factors/genetics/metabolism ; Phenotype ; *Protein Biosynthesis ; RNA Helicases ; RNA Nucleotidyltransferases/genetics/*metabolism ; RNA Splicing ; RNA, Fungal/*genetics ; RNA, Messenger/*genetics ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/enzymology/*genetics ; *Saccharomyces cerevisiae Proteins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Oncogenic transcription factors in the human acute leukemias (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-14
    Description: Chromosomal translocations in the human acute leukemias rearrange the regulatory and coding regions of a variety of transcription factor genes. The resultant protein products can interfere with regulatory cascades that control the growth, differentiation, and survival of normal blood cell precursors. Support for this interpretation comes from the results of gene manipulation studies in mice, as well as the sequence homology of oncogenic transcription factors with proteins known to regulate embryonic development in primitive organisms, including the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Many of these genetic alterations have important prognostic implications that can guide the selection of therapy. The insights gained from studies of translocation-generated oncogenes and their protein products should hasten the development of highly specific, and hence less toxic, forms of leukemia therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Look, A T -- CA-20180/CA/NCI NIH HHS/ -- CA-21765/CA/NCI NIH HHS/ -- CA-59571/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1059-64.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. 38163, USA. thomas.look@stjude.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353180" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Disease ; Animals ; Apoptosis ; Cell Transformation, Neoplastic ; *Gene Expression Regulation, Leukemic ; Genes, Homeobox ; Humans ; Leukemia, Myeloid/*genetics/pathology/therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology/therapy ; Prognosis ; Transcription Factors/*genetics ; *Translocation, Genetic
    Print ISSN: 0036-8075
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    Genetic testing for cancer risk (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-14
    Description: Genetic testing for cancer susceptibility is already part of the clinical management of families with some of the well-defined (but uncommon) inherited cancer syndromes. In cases where the risks associated with a predisposing mutation are less certain, or where there is no clearly effective intervention to offer those with a positive result, its use is more controversial. Careful evaluation of costs and benefits, and of the efficacy of interventions in those found to be at risk, is essential and is only just beginning. An immediate challenge is to ensure that both health professionals and the public understand clearly the issues involved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ponder, B -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1050-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Box 238, Level 3 Lab Block, Hills Road, Cambridge CB2 2QQ, UK. bajp@mole.bio.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353178" target="_blank"〉PubMed〈/a〉
    Keywords: Confidentiality ; Cost-Benefit Analysis ; Female ; Genetic Counseling ; Genetic Predisposition to Disease ; Genetic Services ; *Genetic Testing ; Genetic Variation ; Humans ; Insurance, Health ; Insurance, Life ; Male ; Mutation ; Neoplasms/*diagnosis/*genetics ; Resource Allocation ; Risk Assessment ; Risk Factors ; Uncertainty
    Print ISSN: 0036-8075
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    Spectral technique paints cells in vivid new colors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1990.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221504" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Nucleus/ultrastructure ; Chromosomes, Human/ultrastructure ; Coloring Agents ; *Cytological Techniques ; Female ; Humans ; Image Processing, Computer-Assisted ; Microscopy, Interference/*methods ; Spectrum Analysis ; Uterine Cervical Dysplasia/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Can cloning help save beleaguered species? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 30;276(5317):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9190674" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Zoo/genetics ; Cloning, Molecular ; *Conservation of Natural Resources ; Costs and Cost Analysis ; Cryopreservation ; Female ; Fibroblasts/cytology ; *Genetic Engineering/economics ; Genetic Variation ; Reproduction, Asexual ; Sheep ; Species Specificity
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Metal ion chaperone function of the soluble Cu(I) receptor Atx1 (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-05
    Description: Reactive and potentially toxic cofactors such as copper ions are imported into eukaryotic cells and incorporated into target proteins by unknown mechanisms. Atx1, a prototypical copper chaperone protein from yeast, has now been shown to act as a soluble cytoplasmic copper(I) receptor that can adopt either a two- or three-coordinate metal center in the active site. Atx1 also associated directly with the Atx1-like cytosolic domains of Ccc2, a vesicular protein defined in genetic studies as a member of the copper-trafficking pathway. The unusual structure and dynamics of Atx1 suggest a copper exchange function for this protein and related domains in the Menkes and Wilson disease proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pufahl, R A -- Singer, C P -- Peariso, K L -- Lin, S J -- Schmidt, P J -- Fahrni, C J -- Culotta, V C -- Penner-Hahn, J E -- O'Halloran, T V -- GM-38047/GM/NIGMS NIH HHS/ -- GM-50016/GM/NIGMS NIH HHS/ -- GM-54111/GM/NIGMS NIH HHS/ -- R01 GM054111/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Oct 31;278(5339):853-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9346482" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; *Carrier Proteins ; *Cation Transport Proteins ; Copper/*metabolism ; Escherichia coli ; Fungal Proteins/metabolism/*physiology ; Humans ; Molecular Chaperones/*physiology ; Molecular Sequence Data ; Recombinant Proteins ; Saccharomyces cerevisiae/metabolism/*physiology ; *Saccharomyces cerevisiae Proteins ; Sequence Homology, Amino Acid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Sexual selection in Asian elephants (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tiedemann, R -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1550-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411772" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Elephants/*anatomy & histology/*physiology ; Female ; Incisor/anatomy & histology ; India ; Male ; Models, Biological ; Models, Statistical ; *Sexual Behavior, Animal ; Sri Lanka
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    Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell-specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maisonpierre, P C -- Suri, C -- Jones, P F -- Bartunkova, S -- Wiegand, S J -- Radziejewski, C -- Compton, D -- McClain, J -- Aldrich, T H -- Papadopoulos, N -- Daly, T J -- Davis, S -- Sato, T N -- Yancopoulos, G D -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):55-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9204896" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Angiopoietin-1 ; Angiopoietin-2 ; Animals ; Blood Vessels/embryology/*metabolism ; Cells, Cultured ; Cloning, Molecular ; Embryo, Mammalian/metabolism ; Endothelial Growth Factors/genetics/metabolism ; Endothelium, Vascular/*cytology/metabolism ; Female ; Humans ; Ligands ; Lymphokines/genetics/metabolism ; Membrane Glycoproteins/antagonists & inhibitors/metabolism ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; *Neovascularization, Physiologic ; Phosphorylation ; Proteins/chemistry/*metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism ; Receptor, TIE-2 ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
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    Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: Both subjective and electroencephalographic arousal diminish as a function of the duration of prior wakefulness. Data reported here suggest that the major criteria for a neural sleep factor mediating the somnogenic effects of prolonged wakefulness are satisfied by adenosine, a neuromodulator whose extracellular concentration increases with brain metabolism and which, in vitro, inhibits basal forebrain cholinergic neurons. In vivo microdialysis measurements in freely behaving cats showed that adenosine extracellular concentrations in the basal forebrain cholinergic region increased during spontaneous wakefulness as contrasted with slow wave sleep; exhibited progressive increases during sustained, prolonged wakefulness; and declined slowly during recovery sleep. Furthermore, the sleep-wakefulness profile occurring after prolonged wakefulness was mimicked by increased extracellular adenosine induced by microdialysis perfusion of an adenosine transport inhibitor in the cholinergic basal forebrain but not by perfusion in a control noncholinergic region.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599777/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599777/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porkka-Heiskanen, T -- Strecker, R E -- Thakkar, M -- Bjorkum, A A -- Greene, R W -- McCarley, R W -- R01 MH039683/MH/NIMH NIH HHS/ -- R37 MH39,683/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1997 May 23;276(5316):1265-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Harvard Medical School, Brockton Veterans Administration Medical Center (VAMC), 116 A, 940 Belmont Street, Brockton, MA 02401, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157887" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/antagonists & inhibitors/*physiology ; Animals ; Cats ; Electrophysiology ; Microdialysis ; Prosencephalon/physiology ; Sleep/*physiology ; Sleep Deprivation ; Thioinosine/analogs & derivatives/pharmacology ; Time Factors ; Wakefulness/*physiology
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    NCI reverses one expert panel, sides with another (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):27-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122702" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Age Factors ; Breast Neoplasms/*prevention & control/radiography ; Consensus Development Conferences, NIH as Topic ; Female ; Humans ; *Mammography ; *Mass Screening ; Middle Aged ; *National Institutes of Health (U.S.) ; Randomized Controlled Trials as Topic ; Risk Factors ; United States
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    Human genome agreements (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorimer, B G -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):601-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9019811" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Base Sequence ; DNA, Complementary/*genetics ; Databases, Factual ; *Genome, Human ; Humans ; Intellectual Property ; Publishing ; Research Support as Topic ; Sequence Analysis, DNA ; United States
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    Integrating genetic approaches into the discovery of anticancer drugs (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-14
    Description: The discovery of anticancer drugs is now driven by the numerous molecular alterations identified in tumor cells over the past decade. To exploit these alterations, it is necessary to understand how they define a molecular context that allows increased sensitivity to particular compounds. Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors. Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context. This article outlines some of the ways that yeast genetics can be used to streamline anticancer drug discovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hartwell, L H -- Szankasi, P -- Roberts, C J -- Murray, A W -- Friend, S H -- N01-BC65017/BC/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 7;278(5340):1064-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Seattle Project, Molecular Pharmacology Department, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9353181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents/pharmacology/therapeutic use ; *Drug Design ; *Drug Screening Assays, Antitumor ; Humans ; Mutation ; Neoplasms/*drug therapy/genetics ; Signal Transduction ; Yeasts/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hautamaki, R D -- Kobayashi, D K -- Senior, R M -- Shapiro, S D -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):2002-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9302297" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Count ; Chemokine CCL2/pharmacology ; Gene Targeting ; Lung/pathology ; Macrophages, Alveolar/*enzymology/physiology ; Matrix Metalloproteinase 12 ; Metalloendopeptidases/genetics/*metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Neutrophils ; Plants, Toxic ; Pulmonary Alveoli/pathology ; Pulmonary Emphysema/enzymology/*etiology/pathology ; Smoke/adverse effects ; Smoking/*adverse effects ; Tobacco
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    Pain affect encoded in human anterior cingulate but not somatosensory cortex (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-08-15
    Description: Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in pain affect, hypnotic suggestions were used to alter selectively the unpleasantness of noxious stimuli, without changing the perceived intensity. Positron emission tomography revealed significant changes in pain-evoked activity within anterior cingulate cortex, consistent with the encoding of perceived unpleasantness, whereas primary somatosensory cortex activation was unaltered. These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rainville, P -- Duncan, G H -- Price, D D -- Carrier, B -- Bushnell, M C -- New York, N.Y. -- Science. 1997 Aug 15;277(5328):968-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉D-epartement de Psychologie and Centre de Recherche en Sciences Neurologiques, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9252330" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Affect/*physiology ; *Brain Mapping ; Female ; Frontal Lobe/blood supply/*physiology/radionuclide imaging ; Gyrus Cinguli/blood supply/*physiology/radionuclide imaging ; Humans ; Hypnosis ; Male ; Middle Aged ; Pain/*physiopathology/*psychology ; Pain Measurement ; Regional Blood Flow ; Regression Analysis ; Somatosensory Cortex/blood supply/*physiology/radionuclide imaging ; Thermosensing ; Tomography, Emission-Computed
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    Key player: Kevin Kinsella. The industry's top showman (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036538" target="_blank"〉PubMed〈/a〉
    Keywords: Biotechnology/history/*organization & administration ; Genetics, Medical/history/*organization & administration ; Genome, Human ; History, 20th Century ; Humans ; Industry/history/organization & administration ; Molecular Biology/history/*organization & administration ; United States
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    Developing prescriptions with a personal touch (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 Feb 7;275(5301):776.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036540" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; *Drug Industry ; Genotype ; Humans ; *Pharmacogenetics
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    Biology recapitulates phylogeny (1997)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1997-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hillis, D M -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):218-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Texas, Austin, TX 78712 USA. hillis@bull.zo.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9132943" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Humans ; Likelihood Functions ; Models, Biological ; *Phylogeny ; Software
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    Control of vertebrate left-right asymmetry by a snail-related zinc finger gene (1997)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1997-02-28
    Description: A gene encoding a zinc finger protein of the Snail family, cSnR, is expressed in the right-hand lateral mesoderm during normal chick development. Antisense disruption of cSnR function during the hours immediately preceding heart formation randomized the normally reliable direction of heart looping and subsequent embryo torsion. Implanted ectopic sources of intercellular signal proteins that are involved in establishing normal left-right information randomized the handedness of heart development and also altered the asymmetry of cSnR expression. cSnR thus appears to act downstream of these signals, or perhaps in parallel with the latest expressed of them, the Nodal protein, in controlling the anatomical asymmetry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isaac, A -- Sargent, M G -- Cooke, J -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1301-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036854" target="_blank"〉PubMed〈/a〉
    Keywords: Activin Receptors ; Amino Acid Sequence ; Animals ; Body Patterning/*genetics ; Chick Embryo ; Culture Techniques ; DNA-Binding Proteins/chemistry/*genetics/physiology ; Embryonic Induction/genetics/physiology ; *Gene Expression Regulation, Developmental ; Heart/*embryology ; Hedgehog Proteins ; Levocardia/embryology/genetics ; Mesoderm/*metabolism ; Molecular Sequence Data ; Nodal Protein ; Oligonucleotides, Antisense ; Proteins/genetics/physiology ; RNA, Messenger/genetics/metabolism ; Receptors, Growth Factor/genetics/physiology ; Somites/metabolism ; *Trans-Activators ; *Transforming Growth Factor beta ; Up-Regulation ; Zinc Fingers/*genetics
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    Wound healing--aiming for perfect skin regeneration (1997)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1997-04-04
    Description: The healing of an adult skin wound is a complex process requiring the collaborative efforts of many different tissues and cell lineages. The behavior of each of the contributing cell types during the phases of proliferation, migration, matrix synthesis, and contraction, as well as the growth factor and matrix signals present at a wound site, are now roughly understood. Details of how these signals control wound cell activities are beginning to emerge, and studies of healing in embryos have begun to show how the normal adult repair process might be readjusted to make it less like patching up and more like regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martin, P -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):75-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. paul.martin@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9082989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Coagulation ; Cicatrix/etiology ; Endopeptidases/metabolism ; Epidermis/cytology/embryology ; Epithelial Cells ; Epithelium/physiology ; Growth Substances/physiology ; Hair/physiology ; Humans ; Keratinocytes/physiology ; Keratins/physiology ; Leukocytes/physiology ; Neovascularization, Physiologic ; *Regeneration ; Skin/blood supply/embryology/innervation ; *Skin Physiological Phenomena ; Sweat Glands/physiology ; Transforming Growth Factor beta/physiology ; *Wound Healing
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    Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-21
    Description: Many neuropeptides and peptide hormones require amidation at the carboxyl terminus for activity. Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the amidation of these diverse physiological regulators. The amino-terminal domain of the bifunctional PAM protein is a peptidylglycine alpha-hydroxylating monooxygenase (PHM) with two coppers that cycle through cupric and cuprous oxidation states. The anomalous signal of the endogenous coppers was used to determine the structure of the catalytic core of oxidized rat PHM with and without bound peptide substrate. These structures strongly suggest that the PHM reaction proceeds via activation of substrate by a copper-bound oxygen species. The mechanistic and structural insight gained from the PHM structures can be directly extended to dopamine beta-monooxygenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prigge, S T -- Kolhekar, A S -- Eipper, B A -- Mains, R E -- Amzel, L M -- DK32949/DK/NIDDK NIH HHS/ -- GM44692/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1300-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9360928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Catalysis ; Copper/chemistry/metabolism ; Crystallography, X-Ray ; Dipeptides/metabolism ; Dopamine beta-Hydroxylase/chemistry/metabolism ; Electrons ; Hydroxylation ; Ligands ; Mixed Function Oxygenases/*chemistry/metabolism ; Models, Molecular ; *Multienzyme Complexes ; Oxidation-Reduction ; Oxygen/metabolism ; Peptides/metabolism ; *Protein Conformation ; Protein Structure, Secondary ; Rats
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    Rescue of a Drosophila NF1 mutant phenotype by protein kinase A (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase-activating protein. However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated adenosine 3', 5'-monophosphate-dependent protein kinase (PKA). Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉The, I -- Hannigan, G E -- Cowley, G S -- Reginald, S -- Zhong, Y -- Gusella, J F -- Hariharan, I K -- Bernards, A -- NS22229/NS/NINDS NIH HHS/ -- NS34779/NS/NINDS NIH HHS/ -- NS36084/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 May 2;276(5313):791-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital Cancer Center and Harvard Medical School Building 149, 13th Street, Charlestown, MA 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115203" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Count ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics/*metabolism ; Drosophila/cytology/*genetics/growth & development/metabolism ; *Drosophila Proteins ; GTP Phosphohydrolases/metabolism ; Genes, Insect ; Insect Proteins/chemistry/genetics/*metabolism ; Molecular Sequence Data ; Mutation ; *Nerve Tissue Proteins ; Neurofibromin 1 ; Phenotype ; Proteins/chemistry/genetics ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; *ras GTPase-Activating Proteins ; ras Proteins/metabolism
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    Recombinant DNA technique and sickle cell anemia research (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, K R -- Capecchi, M R -- New York, N.Y. -- Science. 1997 Mar 7;275(5305):1404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9072801" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Anemia, Sickle Cell/*genetics ; B-Lymphocytes ; Cells, Cultured ; DNA, Recombinant ; *Gene Conversion ; Hemoglobin, Sickle/*genetics ; Humans ; Mutation ; Oligonucleotides/*genetics
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    Planned tests in Thailand spark debate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 23;276(5316):1197.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182330" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines ; Acquired Immunodeficiency Syndrome/epidemiology ; *Clinical Trials as Topic/economics ; HIV Envelope Protein gp120 ; Humans ; Thailand/epidemiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    PH domains--a universal membrane adapter (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hemmings, B A -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1899.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute, Post Office Box 2543, Basel, Switzerland. hemmings@fmi.ch〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122692" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/*chemistry ; Cell Adhesion Molecules/metabolism ; Cell Membrane/*metabolism ; GTP-Binding Proteins/metabolism ; *GTPase-Activating Proteins ; Guanine Nucleotide Exchange Factors ; Inositol Phosphates/metabolism ; Phosphatidylinositol 3-Kinases ; Phosphatidylinositol Phosphates/metabolism ; *Phosphoproteins ; Phosphotransferases (Alcohol Group Acceptor)/chemistry/*metabolism ; Proteins/metabolism ; Receptors, Cytoplasmic and Nuclear/metabolism ; Second Messenger Systems ; *Signal Transduction
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ethics of AZT studies in poorer countries attacked (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 16;276(5315):1022.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9173534" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Anti-HIV Agents/administration & dosage/*therapeutic use ; *Bioethics ; Caribbean Region ; *Control Groups ; Controlled Clinical Trials as Topic/*standards ; Female ; HIV Infections/drug therapy/prevention & control/*transmission ; Humans ; Infectious Disease Transmission, Vertical/*prevention & control ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; *Pregnant Women ; Thailand ; Therapeutic Human Experimentation ; Withholding Treatment ; Zidovudine/administration & dosage/*therapeutic use
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    Fluorescence-based isolation of bacterial genes expressed within host cells (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: A selection strategy was devised to identify bacterial genes preferentially expressed when a bacterium associates with its host cell. Fourteen Salmonella typhimurium genes, which were under the control of at least four independent regulatory circuits, were identified to be selectively induced in host macrophages. Four genes encode virulence factors, including a component of a type III secretory apparatus. This selection methodology should be generally applicable to the identification of genes from pathogenic organisms that are induced upon association with host cells or tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valdivia, R H -- Falkow, S -- AI26195/AI/NIAID NIH HHS/ -- DK38707/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):2007-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. valdivia@cmgm.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9302299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Proteins/genetics ; Cell Line ; Cloning, Molecular ; Female ; Flow Cytometry ; Fluorescence ; *Gene Expression Regulation, Bacterial ; Green Fluorescent Proteins ; HeLa Cells ; Humans ; Luminescent Proteins/genetics ; Macrophages/*microbiology ; Mice ; Mice, Inbred BALB C ; Microscopy, Fluorescence ; Molecular Sequence Data ; Open Reading Frames ; Promoter Regions, Genetic ; Recombinant Fusion Proteins ; Salmonella Infections, Animal/microbiology ; Salmonella typhimurium/*genetics/isolation & purification/*pathogenicity ; Spleen/microbiology ; Transcription Factors/genetics ; Virulence/genetics
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Regulation of replicon size in Xenopus egg extracts (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: Once a specific number of cells have been produced in the early Xenopus laevis embryo, replicon size during the S phase of the cell cycle increases. Here, it is reported that similar increase in replicon size occurred when the concentration of nuclei in replication-competent Xenopus egg extracts exceeded a critical threshold. In this system, the origin recognition complex (ORC) did not become stoichiometrically limiting for initiation, and similar amounts of this complex bound to chromatin regardless of replicon size. These data suggest that in early development, an unidentified factor controls how many preformed ORC-DNA complexes initiate DNA replication.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walter, J -- Newport, J W -- 1F32FM17980-01/PHS HHS/ -- R01FM44656/PHS HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):993-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Cycle Proteins/metabolism ; Chromatin/metabolism ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins/pharmacology ; Cytarabine/pharmacology ; DNA/*metabolism ; *DNA Replication ; DNA-Binding Proteins/*metabolism ; Enzyme Inhibitors/pharmacology ; Female ; Origin Recognition Complex ; Ovum/*metabolism ; Replication Origin ; *Replicon ; S Phase ; Xenopus laevis
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    Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: Transport of macromolecules into and out of nuclei, essential steps in gene expression, are potential points of control. The matrix protein (M protein) of vesicular stomatitis virus (VSV) was shown to block transport of RNAs and proteins between the nucleus and cytoplasm of Xenopus laevis oocytes. The pattern of inhibition indicated that M protein interfered with transport that is dependent on the ras-like nuclear guanosine triphosphatase (GTPase) Ran-TC4 and its associated factors. This inhibition of nuclear transport by M protein explains several observations about the effects of VSV infection on host cell gene expression and suggests that RNA export is closely coupled to protein import.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Her, L S -- Lund, E -- Dahlberg, J E -- GM30220/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1845-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188527" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Cell Nucleus/*metabolism ; Cytoplasm/metabolism ; GTP Phosphohydrolases/*metabolism ; Nuclear Envelope/metabolism ; Nuclear Proteins/*metabolism ; Oocytes ; Proteins/*metabolism ; RNA/*metabolism ; RNA Caps ; RNA Precursors/metabolism ; RNA, Messenger/metabolism ; RNA, Ribosomal/metabolism ; RNA, Small Nuclear/metabolism ; RNA, Transfer, Amino Acid-Specific/metabolism ; *Vesicular stomatitis Indiana virus ; Viral Matrix Proteins/*physiology ; Wheat Germ Agglutinins/pharmacology ; Xenopus laevis ; alpha Karyopherins ; ran GTP-Binding Protein
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    A mouse model with features of familial combined hyperlipidemia (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-17
    Description: Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human apolipoprotein C-III (APOC3) transgene with mice deficient in the LDL receptor. A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis. This mouse model may provide clues to the origin of human FCHL.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Masucci-Magoulas, L -- Goldberg, I J -- Bisgaier, C L -- Serajuddin, H -- Francone, O L -- Breslow, J L -- Tall, A R -- HL 21006/HL/NHLBI NIH HHS/ -- HL 54591/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Columbia University, 630 West 168 Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8994037" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apolipoprotein C-III ; Apolipoproteins B/blood ; Apolipoproteins C/*genetics ; Apolipoproteins E/blood ; Arteriosclerosis/etiology ; Carrier Proteins/genetics ; Cholesterol/blood ; Cholesterol Ester Transfer Proteins ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cholesterol, VLDL/blood ; Diet ; *Disease Models, Animal ; Disease Susceptibility ; Female ; *Glycoproteins ; Humans ; *Hyperlipidemia, Familial Combined/blood/genetics ; Hyperlipoproteinemia Type IV/genetics ; Lipoproteins/blood ; Lipoproteins, VLDL/blood ; Male ; Mice ; Mice, Inbred C57BL ; *Mice, Transgenic ; Receptors, LDL/*genetics/metabolism ; Transgenes ; Triglycerides/blood
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    A womb with a view (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1397-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Computer Simulation ; Databases, Factual ; *Diagnostic Imaging ; Embryo, Mammalian/*anatomy & histology/ultrasonography ; *Embryonic and Fetal Development ; Gene Expression Regulation, Developmental ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging/*methods ; Microscopy, Confocal ; Models, Anatomic ; Motion Pictures as Topic
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Aquaporins and ion conductance (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deen, P M -- Mulders, S M -- Kansen, S M -- van Os, C H -- New York, N.Y. -- Science. 1997 Mar 7;275(5305):1491; author reply 1492.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9072810" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-3-isobutylxanthine/pharmacology ; Animals ; Aquaporin 1 ; *Aquaporins ; Blood Group Antigens ; Cations/*metabolism ; *Cell Membrane Permeability/drug effects ; Colforsin/pharmacology ; Cyclic AMP/metabolism ; Humans ; Ion Channels/genetics/*physiology ; Ion Transport ; Oocytes ; Patch-Clamp Techniques ; RNA, Complementary/genetics ; Water/*metabolism ; Xenopus
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    Candid cameras for the nanoworld (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amato, I -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1982-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA/metabolism ; DNA-Directed RNA Polymerases/metabolism ; *Microscopy, Atomic Force/instrumentation/methods ; *Microscopy, Scanning Tunneling/instrumentation/methods ; Nuclear Envelope/physiology/ultrastructure ; Synaptic Vesicles/physiology/ultrastructure
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    'Living fossil' fish is dethroned (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1436.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9304212" target="_blank"〉PubMed〈/a〉
    Keywords: Amphibians/*genetics ; Animals ; *Biological Evolution ; DNA, Mitochondrial/genetics ; Fishes/classification/*genetics ; Phylogeny ; Sequence Analysis, DNA
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    Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in fibroblasts stimulated by extracellular signals such as lysophosphatidic acid (LPA). Rho-kinase is activated by Rho and may mediate some biological effects of Rho. Microinjection of the catalytic domain of Rho-kinase into serum-starved Swiss 3T3 cells induced the formation of stress fibers and focal adhesions, whereas microinjection of the inactive catalytic domain, the Rho-binding domain, or the pleckstrin-homology domain inhibited the LPA-induced formation of stress fibers and focal adhesions. Thus, Rho-kinase appears to mediate signals from Rho and to induce the formation of stress fibers and focal adhesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amano, M -- Chihara, K -- Kimura, K -- Fukata, Y -- Nakamura, N -- Matsuura, Y -- Kaibuchi, K -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1308-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036856" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Actins/*metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; *Cell Adhesion ; Cell Line ; DNA, Complementary/genetics ; Enzyme Inhibitors/pharmacology ; GTP Phosphohydrolases/metabolism ; Intracellular Signaling Peptides and Proteins ; Lysophospholipids/pharmacology ; Mice ; Mutation ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Staurosporine/pharmacology ; rho-Associated Kinases
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    Dictyostelium development in the absence of cAMP (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-11
    Description: Adenosine 3',5'-monophosphate (cAMP) and cAMP-dependent protein kinase (PKA) are regulators of development in many organisms. Dictyostelium uses cAMP as an extracellular chemoattractant and as an intracellular signal for differentiation. Cells that are mutant in adenylyl cyclase do not develop. Moderate expression of the catalytic subunit of PKA in adenylyl cyclase-null cells led to near-normal development without detectable accumulation of cAMP. These results suggest that all intracellular cAMP signaling is effected through PKA and that signals other than extracellular cAMP coordinate morphogenesis in Dictyostelium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, B -- Kuspa, A -- R01 GM052359/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jul 11;277(5323):251-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9211856" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Cloning, Molecular ; Cyclic AMP/*metabolism ; Cyclic AMP-Dependent Protein Kinases/*metabolism ; Dictyostelium/genetics/*growth & development/metabolism ; Enzyme Activation ; Gene Expression Regulation ; Genes, Protozoan ; Morphogenesis ; Signal Transduction ; Transformation, Genetic
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    Chemical selection for catalysis in combinatorial antibody libraries (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-14
    Description: For the past decade the immune system has been exploited as a rich source of de novo catalysts. Catalytic antibodies have been shown to have chemoselectivity, enantioselectivity, large rate accelerations, and even an ability to reroute chemical reactions. In many instances catalysts have been made for reactions for which there are no known natural or man-made enzymes. Yet, the full power of this combinatorial system can only be exploited if there was a system that allows for the direct selection of a particular function. A method that allows for the direct chemical selection for catalysis from antibody libraries was so devised, whereby the positive aspects of hybridoma technology were preserved and re-formatted in the filamentous phage system to allow direct selection of catalysis. This methodology is based on a purely chemical selection process, making it more general than biologically based selection systems because it is not limited to reaction products that perturb cellular machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janda, K D -- Lo, L C -- Lo, C H -- Sim, M M -- Wang, R -- Wong, C H -- Lerner, R A -- GM-43858/GM/NIGMS NIH HHS/ -- GM-44154/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):945-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020070" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibodies, Catalytic/genetics/metabolism ; Catalysis ; Cloning, Molecular ; Coliphages ; Dithiothreitol ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli/genetics/metabolism ; Galactosides/metabolism ; Haptens ; Hybridomas ; Immunoglobulin Fab Fragments/genetics/metabolism ; Indoles/metabolism ; Isopropyl Thiogalactoside/metabolism ; Mice ; Nitrophenylgalactosides/metabolism ; *Peptide Library ; Polymerase Chain Reaction ; Serum Albumin, Bovine ; Transformation, Bacterial ; beta-Galactosidase/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Highly variable mutation rates in commensal and pathogenic Escherichia coli (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matic, I -- Radman, M -- Taddei, F -- Picard, B -- Doit, C -- Bingen, E -- Denamur, E -- Elion, J -- New York, N.Y. -- Science. 1997 Sep 19;277(5333):1833-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9324769" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; DNA Repair/genetics ; Escherichia coli/*genetics/*pathogenicity ; Humans ; *Mutation ; Phenotype ; Virulence
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Tooling around: dates show early Siberian settlement (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1268.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064782" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Archaeology ; *Hominidae ; Humans ; Siberia
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Human subjects research (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vander Hamm, D G -- New York, N.Y. -- Science. 1997 Apr 4;276(5309):17.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122694" target="_blank"〉PubMed〈/a〉
    Keywords: Government Agencies ; *Human Experimentation ; Humans ; *Informed Consent ; *Military Medicine ; Research
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Local hormone networks and intestinal T cell homeostasis (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-28
    Description: Neuroendocrine hormones of the hypothalamus-pituitary-thyroid axis can exert positive or negative immunoregulatory effects on intestinal lymphocytes. Small intestine epithelial cells were found to express receptors for thyrotropin-releasing hormone (TRH) and to be a primary source of intestine-derived thyroid-stimulating hormone (TSH). The gene for the TSH receptor (TSH-R) was expressed in intestinal T cells but not in epithelial cells, which suggested a hormone-mediated link between lymphoid and nonhematopoietic components of the intestine. Because mice with congenitally mutant TSH-R (hyt/hyt mice) have a selectively impaired intestinal T cell repertoire, TSH may be a key immunoregulatory mediator in the intestine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, J -- Whetsell, M -- Klein, J R -- DK35566/DK/NIDDK NIH HHS/ -- R01 DK035566/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 28;275(5308):1937-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Science and Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, Tulsa, OK 74104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9072972" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Homeostasis ; *Immunity, Mucosal ; Intestinal Mucosa/cytology/*immunology/metabolism ; Intestine, Small/cytology/immunology/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Nude ; Point Mutation ; Receptors, Thyrotropin/genetics/metabolism ; Receptors, Thyrotropin-Releasing Hormone/genetics/metabolism ; T-Lymphocyte Subsets/immunology/metabolism ; T-Lymphocytes/*immunology/metabolism ; Thyrotropin/genetics/*metabolism ; Thyrotropin-Releasing Hormone/*metabolism/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Conditional mutator phenotypes in hMSH2-deficient tumor cell lines (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-05
    Description: Two human tumor cell lines that are deficient in the mismatch repair protein hMSH2 show little or no increase in mutation rate relative to that of a mismatch repair-proficient cell line when the cells are maintained in culture conditions allowing rapid growth. However, mutations accumulate at a high rate in these cells when they are maintained at high density. Thus the mutator phenotype of some mismatch repair-deficient cell lines is conditional and strongly depends on growth conditions. These observations have implications for tumor development because they suggest that mutations may accumulate in tumor cells when growth is limited.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richards, B -- Zhang, H -- Phear, G -- Meuth, M -- R01-CA-62244/CA/NCI NIH HHS/ -- T32-CA-09602/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 5;277(5331):1523-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncological Sciences, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9278518" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Count ; *Cell Division ; *DNA Repair ; DNA Replication ; *DNA-Binding Proteins ; Drug Resistance, Neoplasm ; Female ; Frameshift Mutation ; Humans ; Hypoxanthine Phosphoribosyltransferase/genetics ; Microsatellite Repeats ; MutS Homolog 2 Protein ; *Mutation ; Neoplasms/*genetics/pathology ; Ouabain/pharmacology ; Ovarian Neoplasms/genetics/pathology ; Phenotype ; Proto-Oncogene Proteins/genetics/*physiology ; Tumor Cells, Cultured ; Uterine Neoplasms/genetics/pathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Phylogenetic methods come of age: testing hypotheses in an evolutionary context (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-11
    Description: The use of molecular phylogenies to examine evolutionary questions has become commonplace with the automation of DNA sequencing and the availability of efficient computer programs to perform phylogenetic analyses. The application of computer simulation and likelihood ratio tests to evolutionary hypotheses represents a recent methodological development in this field. Likelihood ratio tests have enabled biologists to address many questions in evolutionary biology that have been difficult to resolve in the past, such as whether host-parasite systems are cospeciating and whether models of DNA substitution adequately explain observed sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huelsenbeck, J P -- Rannala, B -- GM40282/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Apr 11;276(5310):227-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Integrative Biology, University of California, Berkeley, CA 94720, USA. john@mws4.biol.berkeley.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9092465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; *Biological Evolution ; Computer Simulation ; *DNA/genetics ; Electron Transport Complex IV/genetics ; *Evolution, Molecular ; Hantavirus/genetics ; Likelihood Functions ; Mutation ; Phthiraptera/genetics ; *Phylogeny ; RNA, Viral/genetics ; Rodentia/genetics
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    Population diversity: its extent and extinction (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-24
    Description: Genetically distinct populations are an important component of biodiversity. This work estimates the number of populations per area of a sample of species from literature on population differentiation and the average range area of a species from a sample of distribution maps. This yields an estimate of about 220 populations per species, or 1.1 to 6.6 billion populations globally. Assuming that population extinction is a linear function of habitat loss, approximately 1800 populations per hour (16 million annually) are being destroyed in tropical forests alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, J B -- Daily, G C -- Ehrlich, P R -- New York, N.Y. -- Science. 1997 Oct 24;278(5338):689-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9381179" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; *Genetics, Population ; Mathematics ; Plants ; Polymorphism, Restriction Fragment Length ; Population Density
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    World AIDS--the worst is still to come (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 Dec 5;278(5344):1715.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411791" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*epidemiology ; Africa, Southern/epidemiology ; Asia/epidemiology ; Family ; *Global Health ; Humans ; India/epidemiology
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    Receptor offers clues to how 'good' cholesterol works (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Husten, L -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1228.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411750" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/metabolism ; Animals ; Antigens, CD36/genetics/*metabolism ; Arteriosclerosis/etiology/metabolism ; *Carrier Proteins ; Cholesterol/blood/metabolism ; Cloning, Molecular ; Humans ; Lipoproteins, HDL/blood/*metabolism ; Liver/metabolism ; *Membrane Proteins ; Mice ; Mice, Knockout ; *RNA-Binding Proteins ; *Receptors, Immunologic ; Receptors, Lipoprotein/genetics/*metabolism ; Receptors, Scavenger ; Scavenger Receptors, Class B
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    SIV hunt leads to baboon virus discovery (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 May 2;276(5313):685.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Betaretrovirus/genetics/*isolation & purification ; DNA, Viral/analysis ; Genes, Viral ; Papio/genetics/*virology ; Simian Immunodeficiency Virus/genetics/isolation & purification
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    New lesion found in diseased brains (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 Jul 4;277(5322):31-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9229767" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/metabolism/*pathology ; Amyloid beta-Peptides/immunology ; Antibodies/immunology ; Binding Sites ; Brain/*pathology ; Brain Chemistry ; Humans ; Phosphates/metabolism ; tau Proteins/immunology/metabolism
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    Mammalian genome debate heats up (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1733.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9122675" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Husbandry ; Animals ; Animals, Genetically Modified ; *Bioethics ; Cloning, Molecular ; Federal Government ; *Genetic Engineering ; Genetic Research ; Government Regulation ; Humans ; Public Policy ; Risk Assessment ; United States
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    Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-12-31
    Description: A lymphocyte subpopulation, the Valpha14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Valpha14 and Jalpha281 gene segments. Mice with a deletion of the Jalpha281 gene segment were found to exclusively lack this subpopulation. The Valpha14 NKT cell-deficient mice could no longer mediate the interleukin-12 (IL-12)-induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, Valpha14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cui, J -- Shin, T -- Kawano, T -- Sato, H -- Kondo, E -- Toura, I -- Kaneko, Y -- Koseki, H -- Kanno, M -- Taniguchi, M -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Bacterial Agents/pharmacology ; *Cytotoxicity, Immunologic ; Gene Deletion ; Gene Targeting ; Genes, RAG-1 ; Genes, T-Cell Receptor alpha ; Interferon-gamma/immunology ; Interleukin-12/*immunology ; Killer Cells, Natural/*immunology ; *Macrolides ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neoplasms, Experimental/*immunology ; Poly I-C/pharmacology ; Proton-Translocating ATPases/antagonists & inhibitors ; Receptors, Antigen, T-Cell, alpha-beta/genetics/*immunology ; T-Lymphocyte Subsets/*immunology
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    Sequencers call for faster data release (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 May 23;276(5316):1189-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182326" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Computer Communication Networks ; *Dna ; Europe ; Germany ; Humans ; *Information Dissemination ; Intellectual Property ; *Internationality ; *Patents as Topic ; Time Factors ; United States
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    Neurons and reaction times (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richer, F -- Achim, A -- New York, N.Y. -- Science. 1997 Jan 10;275(5297):144; author reply 144-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8999542" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*physiology ; Neurons/*physiology ; Reaction Time/*physiology ; Synaptic Transmission
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    Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-20
    Description: A leucine-rich nuclear export signal (NES) allows rapid export of proteins from cell nuclei. Microinjection studies revealed a role for the guanosine triphosphatase (GTPase) Ran in NES-mediated export. Nuclear injection of a Ran mutant (Thr24 --〉 Asn) blocked protein export but not import, whereas depletion of the Ran nucleotide exchange factor RCC1 blocked protein import but not export. However, injection of Ran GTPase-activating protein (RanGAP) into RCC1-depleted cell nuclei inhibited export. Coinjection with Ran mutants insensitive to RanGAP prevented this inhibition. Therefore, NES-mediated protein export appears to require a Ran-GTP complex but does not require Ran-dependent GTP hydrolysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richards, S A -- Carey, K L -- Macara, I G -- EST3207122/ES/NIEHS NIH HHS/ -- GM 50526/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1842-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Vermont, Burlington, VT 05405, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9188526" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport ; Carrier Proteins/metabolism ; *Cell Cycle Proteins ; Cell Line ; Cell Nucleus/*metabolism ; Cricetinae ; Cytoplasm ; DNA-Binding Proteins/metabolism ; GTP Phosphohydrolases/*metabolism ; GTP-Binding Proteins/metabolism ; *GTPase-Activating Proteins ; Glutathione Transferase/metabolism ; Green Fluorescent Proteins ; *Guanine Nucleotide Exchange Factors ; Guanosine Triphosphate/*metabolism ; Luminescent Proteins/metabolism ; Mutation ; Nuclear Envelope/metabolism ; Nuclear Localization Signals ; Nuclear Proteins/genetics/*metabolism ; Receptors, Glucocorticoid/metabolism ; Recombinant Fusion Proteins/metabolism ; Temperature ; ran GTP-Binding Protein
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    Panel weighs a law against cloning (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1997 May 23;276(5316):1185-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182324" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Bioethics ; Cloning, Molecular ; Embryo Research ; Embryo, Mammalian ; *Ethics Committees ; Federal Government ; Financing, Government/legislation & jurisprudence ; Genetic Engineering/*legislation & jurisprudence ; *Government Regulation ; Humans ; Nuclear Transfer Techniques ; Private Sector/legislation & jurisprudence ; Public Policy ; Research Support as Topic/*legislation & jurisprudence ; Sheep
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Polyalanine expansion in synpolydactyly might result from unequal crossing-over of HOXD13 (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warren, S T -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):408-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9005557" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Sequence ; Base Sequence ; *Crossing Over, Genetic ; Homeodomain Proteins/chemistry/*genetics ; Humans ; Molecular Sequence Data ; Mutation ; Peptides/analysis/*genetics ; Polydactyly/*genetics ; Syndactyly/*genetics ; *Transcription Factors ; Trinucleotide Repeats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Biospherian viewpoints (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dempster, W F -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1247-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064774" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arizona ; Atmosphere ; *Ecological Systems, Closed ; *Ecosystem ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Why can't a computer be more like a brain? (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, A -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):1934-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9333946" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Brain/*physiology ; *Computers ; Humans ; Nerve Net/*physiology ; *Neural Networks (Computer) ; Neurons/physiology ; *Robotics ; Transistors, Electronic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Antisense aims for a renaissance (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 May 23;276(5316):1192-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9182327" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotechnology ; Clinical Trials as Topic ; Humans ; Oligonucleotides, Antisense/adverse effects/chemistry/*therapeutic use
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    From science fiction to ethics quandary (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-11-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Sep 19;277(5333):1753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9324757" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; *Bioethics ; Federal Government ; *Genetic Engineering ; *Genetic Enhancement ; *Genetic Research ; *Genetic Therapy ; *Genetics, Medical ; Government Regulation ; Humans ; National Institutes of Health (U.S.) ; Social Change ; United States ; Wedge Argument
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 95
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    Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-14
    Description: Brain research on mental illnesses has made substantial advances in recent years, supported by conceptual and technological developments in cognitive neuroscience. Brain-based cognitive models of illnesses such as schizophrenia and depression have been tested with a variety of techniques, including the lesion method, tract tracing, neuroimaging, animal modeling, single-cell recording, electrophysiology, neuropsychology, and experimental cognitive psychology. A relatively sophisticated picture is emerging that conceptualizes mental illnesses as disorders of mind arising in the brain. Convergent data using multiple neuroscience techniques indicate that the neural mechanisms of mental illnesses can be understood as dysfunctions in specific neural circuits and that their functions and dysfunctions can be influenced or altered by a variety of cognitive and pharmacological factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andreasen, N C -- MH-CRC43271/MH/NIMH NIH HHS/ -- MH31593/MH/NIMH NIH HHS/ -- MH40856/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Mar 14;275(5306):1586-93.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mental Health Clinical Research Center, The University of Iowa Hospitals and Clinics and College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9054346" target="_blank"〉PubMed〈/a〉
    Keywords: Affect ; Animals ; Brain/*physiopathology ; Conditioning, Classical ; Depressive Disorder/*physiopathology/psychology ; Hallucinations/physiopathology ; Humans ; Memory, Short-Term ; Mental Disorders/*physiopathology/psychology ; *Mental Processes ; Prefrontal Cortex/physiopathology ; *Psychopathology ; Psychophysiology ; Schizophrenia/*physiopathology ; Schizophrenic Psychology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 96
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    Whitehead, three firms splice a deal (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roush, W -- New York, N.Y. -- Science. 1997 May 9;276(5314):891.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9163032" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics ; *Biotechnology/economics ; Budgets ; *Drug Industry/economics ; *Genetics, Medical ; *Human Genome Project ; Humans ; Patents as Topic ; Publishing ; Research Support as Topic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    Searching for living relics of the cell's early days (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-10-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1604.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9312854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; DNA, Mitochondrial/*genetics ; Eukaryota/genetics/ultrastructure ; *Eukaryotic Cells/physiology/ultrastructure ; *Genes, Bacterial ; Giardia lamblia/physiology/ultrastructure ; Microsporida/physiology/ultrastructure ; *Mitochondria/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
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    Yeast protein acting alone triggers prion-like process (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Jul 18;277(5324):314.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9518359" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fungal Proteins/*chemistry/isolation & purification/physiology ; Peptide Termination Factors ; Prions/*chemistry ; Protein Biosynthesis ; *Protein Conformation ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Saccharomyces cerevisiae/*chemistry/genetics ; *Saccharomyces cerevisiae Proteins ; Solubility
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    NCI plans attack on HIV resistance (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 May 2;276(5313):667.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9157541" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*drug therapy/virology ; Anti-HIV Agents/*pharmacology/therapeutic use ; Drug Resistance, Microbial ; HIV/*drug effects ; Humans ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Gene discovery offers tentative clues to Parkinson's (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):1973.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9221499" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; Chromosomes, Human, Pair 4 ; Genetic Markers ; Humans ; Lewy Bodies/chemistry ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/analysis/chemistry/*genetics ; Oxidative Stress ; Parkinson Disease/etiology/*genetics ; Point Mutation ; Protein Conformation ; Protein Folding ; Rats ; Synucleins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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