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  • 1
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    Low-voltage harmonic multiplying gyrotron traveling-wave amplifier in G band (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-12-19
    Description: Harmonic multiplying operation in a gyrotron traveling-wave amplifier (gyro-TWA) permits for magnetic field reduction and frequency multiplication. Lowering a beam voltage is an important step toward miniaturization of a harmonic multiplying gyro-TWA. However, the additional degree of freedom that is provided by the multitude cyclotron harmonics in a low-voltage harmonic multiplying gyro-TWA still easily generates various competing modes. An improved mode-selective circuit, using circular waveguides with various radii, can provide the rejection points within the frequency range to suppress competing modes. Simulated results reveal that the mode-selective circuit can provide an attenuation of more than 14 dB to suppress the competing modes. Furthermore, the performance of the gyro-TWA is analyzed for studying the sensitivity of the saturated output power and full width at half maximum bandwidth of the gyro-TWA to the beam voltage and the magnetic field. A stable low-voltage harmonic multiplying gyro-TWA with the mode-selective circuit is predicted to yield a peak output power of 24 kW at 200.4 GHz, corresponding to a saturated gain of 56 dB at an interaction efficiency of 20%. The full width at half maximum bandwidth is 3.0 GHz.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 2
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    WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma (2013)
    Springer Nature
    Details
    Publication Date: 2013-09-06
    Description: WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma Cell Death and Disease 4, e792 (September 2013). doi:10.1038/cddis.2013.308 Authors: C-W Tsai, F-J Lai, H-M Sheu, Y-S Lin, T-H Chang, M-S Jan, S-M Chen, P-C Hsu, T-T Huang, T-C Huang, M-C Sheen, S-T Chen, W-C Chang, N-S Chang & L-J Hsu
    Keywords: tumor suppressormethotrexatechemotherapyautophagyapoptosis
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
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    Requirement of the DEAD-Box protein ded1p for messenger RNA translation (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-03-07
    Description: The DED1 gene, which encodes a putative RNA helicase, has been implicated in nuclear pre-messenger RNA splicing in the yeast Saccharomyces cerevisiae. It is shown here by genetic and biochemical analysis that translation, rather than splicing, is severely impaired in two newly isolated ded1 conditional mutants. Preliminary evidence suggests that the protein Ded1p may be required for the initiation step of translation, as is the distinct DEAD-box protein, eukaryotic initiation factor 4A (eIF4A). The DED1 gene could be functionally replaced by a mouse homolog, PL10, which suggests that the function of Ded1p in translation is evolutionarily conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chuang, R Y -- Weaver, P L -- Liu, Z -- Chang, T H -- GM48752/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Mar 7;275(5305):1468-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular, Cellular, and Developmental Biology Program, Ohio State University, Columbus, OH 43210, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9045610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytoplasm/metabolism ; DEAD-box RNA Helicases ; Eukaryotic Initiation Factor-4A ; Genes, Fungal ; Mice ; Mutation ; Peptide Initiation Factors/genetics/metabolism ; Phenotype ; *Protein Biosynthesis ; RNA Helicases ; RNA Nucleotidyltransferases/genetics/*metabolism ; RNA Splicing ; RNA, Fungal/*genetics ; RNA, Messenger/*genetics ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/enzymology/*genetics ; *Saccharomyces cerevisiae Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Architecture and evolution of a minute plant genome (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-05-15
    Description: It has been argued that the evolution of plant genome size is principally unidirectional and increasing owing to the varied action of whole-genome duplications (WGDs) and mobile element proliferation. However, extreme genome size reductions have been reported in the angiosperm family tree. Here we report the sequence of the 82-megabase genome of the carnivorous bladderwort plant Utricularia gibba. Despite its tiny size, the U. gibba genome accommodates a typical number of genes for a plant, with the main difference from other plant genomes arising from a drastic reduction in non-genic DNA. Unexpectedly, we identified at least three rounds of WGD in U. gibba since common ancestry with tomato (Solanum) and grape (Vitis). The compressed architecture of the U. gibba genome indicates that a small fraction of intergenic DNA, with few or no active retrotransposons, is sufficient to regulate and integrate all the processes required for the development and reproduction of a complex organism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibarra-Laclette, Enrique -- Lyons, Eric -- Hernandez-Guzman, Gustavo -- Perez-Torres, Claudia Anahi -- Carretero-Paulet, Lorenzo -- Chang, Tien-Hao -- Lan, Tianying -- Welch, Andreanna J -- Juarez, Maria Jazmin Abraham -- Simpson, June -- Fernandez-Cortes, Araceli -- Arteaga-Vazquez, Mario -- Gongora-Castillo, Elsa -- Acevedo-Hernandez, Gustavo -- Schuster, Stephan C -- Himmelbauer, Heinz -- Minoche, Andre E -- Xu, Sen -- Lynch, Michael -- Oropeza-Aburto, Araceli -- Cervantes-Perez, Sergio Alan -- de Jesus Ortega-Estrada, Maria -- Cervantes-Luevano, Jacob Israel -- Michael, Todd P -- Mockler, Todd -- Bryant, Douglas -- Herrera-Estrella, Alfredo -- Albert, Victor A -- Herrera-Estrella, Luis -- 4367/Howard Hughes Medical Institute/ -- England -- Nature. 2013 Jun 6;498(7452):94-8. doi: 10.1038/nature12132. Epub 2013 May 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratorio Nacional de Genomica para la Biodiversidad, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, 36821 Irapuato, Guanajuato, Mexico.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23665961" target="_blank"〉PubMed〈/a〉
    Keywords: Angiosperms/*genetics ; DNA, Intergenic/genetics ; *Evolution, Molecular ; Gene Duplication/genetics ; Genes, Plant/genetics ; Genome, Plant/*genetics ; Models, Genetic ; Solanum/genetics ; Synteny/genetics ; Vitis/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Notum deacylates Wnt proteins to suppress signalling activity (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-03-04
    Description: Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wnt proteins from the cell surface. However, this view fails to explain specificity, as glypicans bind many extracellular ligands. Here we provide genetic evidence in Drosophila that Notum requires glypicans to suppress Wnt signalling, but does not cleave their glycophosphatidylinositol anchor. Structural analyses reveal glycosaminoglycan binding sites on Notum, which probably help Notum to co-localize with Wnt proteins. They also identify, at the active site of human and Drosophila Notum, a large hydrophobic pocket that accommodates palmitoleate. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376489/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376489/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kakugawa, Satoshi -- Langton, Paul F -- Zebisch, Matthias -- Howell, Steven A -- Chang, Tao-Hsin -- Liu, Yan -- Feizi, Ten -- Bineva, Ganka -- O'Reilly, Nicola -- Snijders, Ambrosius P -- Jones, E Yvonne -- Vincent, Jean-Paul -- 090532/Wellcome Trust/United Kingdom -- 090532/Z/09/Z/Wellcome Trust/United Kingdom -- 294523/European Research Council/International -- A10976/Cancer Research UK/United Kingdom -- C375/A10976/Cancer Research UK/United Kingdom -- G0900084/Medical Research Council/United Kingdom -- MC_U117584268/Medical Research Council/United Kingdom -- U117584268/Medical Research Council/United Kingdom -- WT093378MA/Wellcome Trust/United Kingdom -- WT099197MA/Wellcome Trust/United Kingdom -- England -- Nature. 2015 Mar 12;519(7542):187-92. doi: 10.1038/nature14259. Epub 2015 Feb 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC's National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. ; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. ; Glycosciences Laboratory, Imperial College London, Department of Medicine, Du Cane Road, London W12 0NN, UK. ; Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25731175" target="_blank"〉PubMed〈/a〉
    Keywords: Acylation ; Animals ; Binding Sites ; Carboxylesterase/chemistry/*metabolism ; Drosophila Proteins/chemistry/*metabolism ; Esterases/chemistry/genetics/*metabolism ; Fatty Acids, Monounsaturated/metabolism ; Glycosylphosphatidylinositols/metabolism ; Glypicans/metabolism ; Humans ; Kinetics ; Ligands ; Mass Spectrometry ; Models, Molecular ; Protein Binding ; Wnt Proteins/*chemistry/*metabolism ; *Wnt Signaling Pathway
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    An adaptive workflow coupled with Random Forest algorithm to identify intact N-glycopeptides detected from mass spectrometry (2014)
    Oxford University Press
    Details
    Publication Date: 2014-06-27
    Description: Motivation: Despite many attempts for algorithm development in recent years, automated identification of intact glycopeptides from LC-MS 2 spectral data is still a challenge in both sensitivity and precision. Results: We implemented a supervised machine learning algorithm, Random Forest, in an automated workflow to identify N-glycopeptides using spectral features derived from ion trap-based LC-MS 2 data. The workflow streamlined high-confident N-glycopeptide spectral data and enabled adaptive model optimization with respect to different sampling strategies, training sample size and feature set. A critical evaluation of the features important for glycopeptide identification further facilitated effective feature selection for model improvement. Using split sample testing method from 577 high-confident N-glycopeptide spectral data, we demonstrated that an optimal true-positive rate, precision and false-positive rate of 73, 88 and 10%, respectively, can be attained for overall N-glycopeptide identification Availability and implementation: The workflow developed in this work and the application suite, Sweet-Heart, that the workflow supports for N-glycopeptide identification are available for download at http://sweet-heart.glycoproteomics.proteome.bc.sinica.edu.tw/ . Contact: syliang@gate.sinica.edu.tw or kkhoo@gate.sinica.edu.tw Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 7
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    Frequency-dependent cavity lifetime and apparent superluminality in Fabry-Pérot-like interferometers (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-11-29
    Description: Author(s): H. Y. Yao, N. C. Chen, T. H. Chang, and H. G. Winful Extraordinary group delays shorter than the transit time of light propagating at c through an equal distance have been experimentally demonstrated in single-Fabry-Pérot (FP) waveguide systems and cascaded-FP structures under off-resonant conditions. These “superluminal” phenomena are well explained ... [Phys. Rev. A 86, 053832] Published Wed Nov 28, 2012
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Determination of direction of littoral transport along the north shore of Santa Rosa Island, Florida (2021)
    Coastal and Oceanographic Engineering Department, University of Florida | Gainesville, FL
    In:  http://aquaticcommons.org/id/eprint/1474 | 3 | 2011-09-29 20:31:13 | 1474 | Oceanographic Engineering Program, Department of Civil and Coastal Engineering, University of Florida
    Details
    Publication Date: 2021-07-08
    Description: The purpose of this study was to determinethe actual direction of littoral transport along the north shore of SantaRosa Island in the vicinity of Pensacola Beach, Florida. To accomplish thisobjective the sand tracer method was used for the study. Visual observationsand instrument recordings of the environment factors were also made duringthe tracing operations. The investigation covered a time span from September14, 1976 to March 12, 1977.(PDF contains 68 pages.)
    Description: Sponsor: Department-of the Army Mobile District, Corps of Engineers Mobile, Alabama
    Keywords: Oceanography ; Engineering ; Santa Rosa Island ; Florida ; Longshore sediment transport
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Rubidium-87 dynamic-angle spinning NMR spectroscopy of inorganic rubidium salts (1992)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 7489-7493 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00045a023
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  • 10
    Electronic Resource
    Electronic Resource
    Dual-function circular polarization converter for microwave/plasma processing systems (1999)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 1530-1534 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Generation of a uniform density plasma has been a key consideration in the design of microwave/plasma processing systems. A circularly polarized wave can generate a plasma with good azimuthal uniformity as well as provide strong resonant interaction with the plasma electrons. In this article, we report the development of a three-port polarization converter which efficiently converts the TE10 wave of a standard rectangular waveguide into a circularly polarized TE11 wave of a cylindrical waveguide. Employing the same principle for mode conversion, the converter is also made to function as a protective device of the high power microwave source by providing a separate port for the return and damping of the reflected wave. Such a converter has been analyzed, constructed, and tested. At the operating frequency of 2.45 GHz, test results indicate a 25 dB return loss, 97% end-to-end polarization conversion efficiency, and better than 20 dB rejection of the reflected wave. The structural simplicity of the device allows high power operation as well as easy construction for system research and applications. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149619
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