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  • Articles  (39)
  • Latest Papers from Table of Contents or Articles in Press  (39)
  • Rabbits  (21)
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  • EARTH RESOURCES AND REMOTE SENSING
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  • American Association for the Advancement of Science (AAAS)  (39)
  • 2020-2022
  • 1990-1994
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  • 1982  (39)
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  • Articles  (39)
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  • Latest Papers from Table of Contents or Articles in Press  (39)
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  • American Association for the Advancement of Science (AAAS)  (39)
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  • 1
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Role for the adenosine triphosphate-dependent proteolytic pathway in reticulocyte maturation (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-19
    Description: As reticulocytes mature into erythrocytes, organelles and many enzymes are lost. Protein degradation during reticulocyte maturation was measured by monitoring the release of tyrosine from cell proteins. Proteolysis in rabbit red blood cells was directly proportional to the number of reticulocytes and was low in erythrocytes. This process was inhibited by blockers of cellular adenosine triphosphate production and by agents, such as o-phenanthroline, N-ethylmaleimide, and hemin, which inhibit the soluble adenosine triphosphate-dependent proteolytic system. The breakdown of endogenous proteins in reticulocyte extracts was also inhibited by these agents and required adenosine triphosphate. Inhibitors of lysosomal function, however, did not affect proteolysis. Thus, the proteolytic system that degrades abnormal proteins also catalyzes the elimination of proteins during red cell development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boches, F S -- Goldberg, A L -- New York, N.Y. -- Science. 1982 Feb 19;215(4535):978-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7156977" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/*physiology ; Animals ; Blood Proteins/*metabolism ; Cell Differentiation ; Cyclophosphamide/pharmacology ; Deoxyglucose/pharmacology ; Dinitrophenols/pharmacology ; Lysosomes/enzymology ; Rabbits ; Reticulocytes/*physiology ; Tyrosine/analysis
    Print ISSN: 0036-8075
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  • 3
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
    Print ISSN: 0036-8075
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  • 4
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Significance of tissue myo-inositol concentrations in metabolic regulation in nerve (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Approximately 25 percent of resting energy utilization in isolated nerve endoneurium is inhibited by medium containing defatted albumin and selectively restored by arachidonic acid but is unaffected by indomethacin or nordihydroguaiaretic acid. The same component of energy utilization is inhibited by small decreases in endoneurial myo-inositol, which decrease incorporation of carbon-14-labeled arachidonic acid into phosphatidylinositol. The fraction of the resting oxygen uptake inhibited by ouabain is decreased 40 to 50 percent by a reduced tissue myo-inositol concentration or by defatted albumin. Metabolic regulation by rapid, basal phosphatidylinositol turnover is dependent on the maintenance of normal tissue myoinositol concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simmons, D A -- Winegrad, A I -- Martin, D B -- T32 AMO7314/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):848-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285474" target="_blank"〉PubMed〈/a〉
    Keywords: Albumins/pharmacology ; Animals ; Arachidonic Acid ; Arachidonic Acids/pharmacology ; Catechols/pharmacology ; Indomethacin/pharmacology ; Inositol/*metabolism ; Linolenic Acids/pharmacology ; Masoprocol ; Ouabain/pharmacology ; Oxygen Consumption ; Palmitic Acids/pharmacology ; Peripheral Nerves/*metabolism ; Phosphatidylinositols/metabolism ; Rabbits ; gamma-Linolenic Acid
    Print ISSN: 0036-8075
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  • 6
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    Evidence for the clonal origin of spontaneous metastases (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmadge, J E -- Wolman, S R -- Fidler, I J -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Aberrations ; Genetic Markers ; Karyotyping ; Lung Neoplasms/secondary ; Melanoma ; Mice ; Mice, Inbred C3H ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology
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  • 7
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    Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, N -- Okada, M -- Koyanagi, Y -- Kannagi, M -- Hinuma, Y -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6980467" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Cell Line ; Fetal Blood ; Genes, Viral ; Humans ; Karyotyping ; Leukocytes/*physiology ; Retroviridae/*genetics ; T-Lymphocytes/immunology ; *Transformation, Genetic
    Print ISSN: 0036-8075
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  • 8
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
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  • 9
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    Destruction of noradrenergic neurons in rabbit brainstem elevates plasma vasopressin, causing hypertension (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-13
    Description: When A1 noradrenergic neurons in the caudal ventrolateral medulla of rabbits are destroyed electrolytically or by local injection of the neurotoxin kainic acid, the concentration of vasopressin in plasma increases, causing hypertension. The A1 neurons may tonically inhibit the activity of vasopressin-secreting neuroendocrine cells through a direct hypothalamic projection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blessing, W W -- Sved, A F -- Reis, D J -- HL 1894/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 13;217(4560):661-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124043" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*physiology ; Animals ; Arginine Vasopressin/*blood ; Blood Pressure ; Brain Stem/*physiology ; Glutamates/pharmacology ; Glutamic Acid ; Hypertension/*etiology ; Hypothalamus/physiology ; Kainic Acid/pharmacology ; Male ; Neurosecretion ; Norepinephrine/physiology ; Rabbits
    Print ISSN: 0036-8075
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  • 10
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    Lyme disease-a tick-borne spirochetosis? (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burgdorfer, W -- Barbour, A G -- Hayes, S F -- Benach, J L -- Grunwaldt, E -- Davis, J P -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1317-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7043737" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachnid Vectors/*microbiology ; Arthritis, Infectious/*microbiology ; Digestive System/microbiology ; Fluorescent Antibody Technique ; Humans ; Microscopy, Electron ; Microvilli/microbiology/ultrastructure ; Rabbits ; Seasons ; Spirochaetales/ultrastructure ; Spirochaetales Infections/*microbiology ; Ticks/*microbiology
    Print ISSN: 0036-8075
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  • 11
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    Naloxone reverses neonatal depression caused by fetal asphyxia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-11
    Description: Pregnant near-term rabbits were given an intravenous dose of saline or the opiate antagonist naloxone and then asphyxiated. The fetuses were delivered by cesarean section and evaluated for respiration, color, muscle tone, response to stimulation, and general activity at 1, 3, 5, 10, 15, and 30 minutes of age. The naloxone-treated pups had significantly better scores during the first 15 minutes after birth than the saline-treated pups. Naloxone did not adversely affect the scores of nonasphyxiated pups. These data suggest that endogenous opiates worsen the neonatal depression caused by intrauterine asphyxia and that this effect can be reversed by naloxone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chernick, V -- Craig, R J -- New York, N.Y. -- Science. 1982 Jun 11;216(4551):1252-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7200636" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Asphyxia Neonatorum/complications/*physiopathology ; Depression/prevention & control ; Disease Models, Animal ; Humans ; Infant, Newborn ; Naloxone/*pharmacology ; Rabbits
    Print ISSN: 0036-8075
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  • 12
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    Migration inhibition of endothelial cells by lymphokine-containing supernatants (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M C -- Picciano, P T -- Douglas, W J -- Yoshida, T -- Kreutzer, D L -- Cohen, S -- AI-12477/AI/NIAID NIH HHS/ -- HL-25015/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797069" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Migration Inhibition ; Cell Movement/drug effects ; Endothelium/cytology/*drug effects ; Humans ; Leukocyte Migration-Inhibitory Factors/pharmacology ; Lymphokines/*pharmacology ; Macrophages/drug effects ; Mast-Cell Sarcoma/physiopathology
    Print ISSN: 0036-8075
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  • 13
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    Phagocyte impotence caused by an invasive bacterial adenylate cyclase (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-03
    Description: For unknown reasons, humans infected with the bacterium Bordetella pertussis are exceptionally vulnerable to secondary infections. Bordetella species elaborate a soluble, heat-stable, and highly active adenylate cyclase. This enzyme is internalized by phagocytic cells and catalyzes the unregulated formation of adenosine 3',5'-monophosphate (cyclic AMP), thereby disrupting normal cellular function. This unusual phenomenon may explain Bordetella-induced aphylaxis and may prove to be useful for investigating a variety of cyclic AMP-governed processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Confer, D L -- Eaton, J W -- 5T32H- L07062/PHS HHS/ -- New York, N.Y. -- Science. 1982 Sep 3;217(4563):948-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287574" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Bordetella pertussis/*enzymology ; Cells, Cultured ; Cyclic AMP/biosynthesis ; Humans ; Macrophages/physiology ; Neutrophils/physiology ; Phagocytes/*physiology ; Rabbits ; Superoxides/metabolism ; Temperature
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  • 14
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    Coupling of histone and DNA synthesis in the somatic cell cycle (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delegeane, A M -- Lee, A S -- 2S07RR05356/RR/NCRR NIH HHS/ -- CA27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cricetinae ; DNA/biosynthesis ; *DNA Replication ; Histones/*biosynthesis ; Mutation
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  • 15
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    Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Progesterone 21-hydroxylase activity varies extensively among liver microsomes prepared from individual New Zealand White (NZW) rabbits. The 21-hydroxylase activities are distributed between two groupings that differ by more than tenfold in mean activity. Both male and female animals are represented in the two groupings. However, females exhibited the higher activity more frequently than males. The 21-hydroxylation of progesterone is catalyzed by one of the liver microsomal cytochrome P-450 isozymes, form 1, and these differences in activity are suggestive of differences in the occurrence of this isozyme among NZW rabbits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dieter, H H -- Muller-Eberhard, U -- Johnson, E F -- HD04445/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):741-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6808664" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytochrome P-450 Enzyme System/metabolism ; Desoxycorticosterone/metabolism ; Female ; Isoenzymes/metabolism ; Liver/*enzymology ; Male ; Microsomes, Liver/metabolism ; NADPH-Ferrihemoprotein Reductase/metabolism ; Progesterone/*metabolism ; Rabbits ; Sex Factors ; Steroid 21-Hydroxylase/*metabolism ; Steroid Hydroxylases/*metabolism
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  • 16
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    Biological diversity in metastatic neoplasms: origins and implications (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- Hart, I R -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):998-1003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112116" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/pathology ; Clone Cells ; Humans ; Immunity ; Melanoma/genetics/pathology ; Mice ; Mice, Inbred Strains ; Mutation ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology ; Phenotype ; Skin Neoplasms/genetics/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cholinergic agonists induce vectorial release of serotonin from duodenal enterochromaffin cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: Serotonin-containing enterochromaffin cells in the rabbit duodenal mucosa span the tissue contacting both the luminal and serosal sides. When the serosal surface is stimulated with carbachol in vitro, serotonin is secreted on the serosal side but not the mucosal side. Carbachol added to the luminal side is ineffective. Atropine but not hexamethonium blocks the effect of carbachol. Acetylcholine on the serosal surface also stimulates serotonin release on the serosal side. These findings indicate that enterochromaffin cells possess on their serosal surfaces muscarinic receptors that mediate vectorial release of serotonin when activated by cholinergic agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forsberg, E J -- Miller, R J -- DA 02121/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):355-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089569" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/pharmacology ; Animals ; Atropine/pharmacology ; Carbachol/pharmacology ; Chromaffin System/*secretion ; Duodenum/physiology ; Enterochromaffin Cells/*secretion ; Hexamethonium Compounds/pharmacology ; In Vitro Techniques ; Intestinal Mucosa/drug effects ; Parasympathomimetics/*pharmacology ; Rabbits ; Receptors, Muscarinic/metabolism ; Serotonin/*secretion ; Serous Membrane/drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Sugar infusion can enhance feeding (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-29
    Description: An investigation was made of the role of glucose in the regulation of hunger and satiety in the rabbit. Glucose, when infused intraduodenally at a low rate (1 milliliter per minute), produced a decrease in food intake. However, when glucose was infused into the duodenum at a high rate (3 milliliters per minute), the rabbits nearly doubled their food intake during the first half-hour after infusion. It is hypothesized that the rapid arrival and glucose in the duodenum may produce hunger.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geiselman, P J -- Novin, D -- NS7687/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):490-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123251" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Glucose/physiology ; Duodenum/*physiology ; Female ; Glucose/administration & dosage/*pharmacology ; Rabbits ; Satiation/*drug effects ; Satiety Response/*drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Interspecies variations in mammalian lens metabolites as detected by phosphorus-31 nuclear magnetic resonance (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: Multiple interspecies differences were detected between humans and seven other mammals in 15 of the 24 metabolites measured in the intact crystalline lens and lens perchloric acid extracts. Generally, the number of statistically significant metabolite differences among the various species, relative to the human, increase in the following order: cat or approximately dog greater than pig greater than rat greater than sheep greater than rabbit greater than cow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kopp, S J -- Glonek, T -- Greiner, J V -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1622-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071581" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Animals ; Carbohydrate Metabolism ; Cats ; Choline/metabolism ; Dogs ; Humans ; Lens, Crystalline/*metabolism ; Magnetic Resonance Spectroscopy ; Phosphocreatine/metabolism ; Rabbits ; Rats ; Species Specificity
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  • 21
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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  • 22
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    New angiogenesis inhibitor identified (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1304.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6177046" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/blood supply ; Neovascularization, Pathologic/*drug effects ; Protamines/*pharmacology ; Rabbits
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Sleep-promoting factor isolated (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6124035" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetylmuramyl-Alanyl-Isoglutamine/*analogs & derivatives ; Alanine/analysis ; Animals ; Cats ; Diaminopimelic Acid/analysis ; Glutamates/analysis ; Glutamic Acid ; Glycopeptides/*urine ; Humans ; Intestines/microbiology ; Muramic Acids/analysis ; Polysaccharides, Bacterial/analysis ; Rabbits ; Rats ; Sleep/*drug effects
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 24
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    Selective, naloxone-reversible morphine depression of learned behavioral and hippocampal responses (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: Morphine administered intravenously causes immediate and complete abolition of a simple learned response (classically conditioned nictitating membrane extension in rabbit) and of the associated learning-induced increase in hippocampal neuron activity. Both effects are completely reversed by low doses of naloxone. Morphine has no effect at all on behavioral performance of the unconditioned reflex response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M D -- Warren, J T -- Thompson, R F -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Conditioning (Psychology)/*drug effects ; Hippocampus/*physiology ; Memory/drug effects ; Morphine/antagonists & inhibitors/*pharmacology ; Naloxone/pharmacology ; Rabbits
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  • 25
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    Neonatal treatment with antiserum to prolactin lowers blood pressure in rats (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: Prolactin administration reportedly increases blood pressure in rats and rabbits. To study the effects of prolactin deficiency on blood pressure, rats were given saline, normal rabbit serum, or rabbit antiserum to rat prolactin on postnatal days 2 to 5. Both males and females given antiserum had significantly lower blood pressure at 14 weeks than rats given saline or normal rabbit serum. Blood pressure differences between females given antiserum and females given saline disappeared during and following pregnancy. The antiserum also lowered the concentration of prolactin in plasma 49 percent in males and decreased the prolactin response to ether stress in both sexes. These results suggest that endogenous prolactin is involved in blood pressure regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mills, D E -- Buckman, M T -- Peake, G T -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):162-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Blood Pressure ; Female ; Immune Sera/pharmacology ; Male ; Pregnancy ; Pregnancy, Animal ; Prolactin/blood/immunology/*physiology ; Rabbits ; Rats ; Rats, Inbred Strains ; Sex Characteristics ; Sodium Chloride/pharmacology
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  • 26
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    Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-10-08
    Description: Protein phosphorylation in cerebral cell-free preparations from neonate rabbits was inhibited by bilirubin and promoted by aminophylline when these substances had been administered intravenously. In animals given both compounds, the bilirubin-induced inhibition of phosphorylation was partly reversed by aminophylline. Adenosine 3',5'-monophosphate added in vitro during the assays also increased protein phosphorylation. These data introduce new concepts in the pathogenesis of kernicterus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morphis, L -- Constantopoulos, A -- Matsaniotis, N -- Papaphilis, A -- New York, N.Y. -- Science. 1982 Oct 8;218(4568):156-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123226" target="_blank"〉PubMed〈/a〉
    Keywords: Aminophylline/pharmacology ; Animals ; Animals, Newborn ; Bilirubin/metabolism/*pharmacology ; Brain/drug effects/*metabolism ; Kinetics ; Nerve Tissue Proteins/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rabbits
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  • 27
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    Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-22
    Description: A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, K M -- Goldberger, G -- Colten, H R -- Aden, D P -- Knowles, B B -- AM 16392/AM/NIADDK NIH HHS/ -- CA 18470/CA/NCI NIH HHS/ -- CA 25875/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):399-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Complement C3/*biosynthesis ; Humans ; Liver Neoplasms, Experimental/*metabolism ; Macromolecular Substances ; Molecular Weight ; Protein Precursors/metabolism
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    Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-15
    Description: Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, H M -- Chen, I -- DeVault, M R -- Lewis, A E -- N01-CB-84316/CB/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181563" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Breast/*physiology ; Female ; Humans ; Iris/*blood supply ; Middle Aged ; *Neovascularization, Pathologic ; Precancerous Conditions/*physiopathology ; Rabbits ; Time Factors
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  • 29
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    Mucus secretion-stimulating activity in human lymphoblastoid cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Two fractions isolated from cultured lymphoblastoid cells stimulated mucus secretion from the urn cell complex of the marine invertebrate Sipunculus nudus. The activity detected in the nuclear fraction was trypsin-sensitive, and it increased in response to specific nucleotides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kulemann-Kloene, H -- Krag, S S -- Bang, F B -- 5P50 HL-19157/HL/NHLBI NIH HHS/ -- CA-00640/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):736-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Fractionation ; Cell Line ; Cell Nucleus/analysis ; Cytoplasm/analysis ; Deoxyribonuclease I ; Deoxyribonucleases/pharmacology ; Endonucleases/pharmacology ; Humans ; Lymphocytes/*metabolism ; Mucus/*secretion ; Nematoda/*metabolism ; Temperature ; Trypsin/pharmacology
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 31
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    Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-24
    Description: Both 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) increased the short-circuit current (Isc) in rabbit colonic mucosa mounted in vitro in Ussing chambers. Measurements of chlorine-36 fluxes indicated that the Isc response to 5-HPETE is due to stimulation of active chlorine secretion. 9-, 11-, and 12-HPETE's and leukotrienes C4 and B4 produced either very small increases in Isc or no increase. In contrast to results in rabbit colon, no HPETE, HETE, or leukotriene was effective in rabbit ileal mucosa. The effects of 5-HPETE in the rabbit colon were unaffected by mepacrine, but could be partially blocked by indomethacin. These results suggest that drugs which block both cyclooxygenase and lipoxygenase may be effective antidiarrheals in patients with colitis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Musch, M W -- Miller, R J -- Field, M -- Siegel, M I -- AM 21345/AM/NIADDK NIH HHS/ -- DA 02121/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 24;217(4566):1255-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810465" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/*pharmacology ; Bicarbonates/metabolism ; Chlorides/metabolism ; Colitis/physiopathology ; Colon/*physiopathology ; Diarrhea/*physiopathology ; *Hydroxyeicosatetraenoic Acids ; Ileum/physiopathology ; Indomethacin/pharmacology ; *Leukotrienes ; *Lipoxygenase Inhibitors ; Rabbits
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  • 32
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Hybridomas: the making of a revolution (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1073-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7038873" target="_blank"〉PubMed〈/a〉
    Keywords: Allergy and Immunology/*history ; Animals ; Cell Line ; History, 20th Century ; Hybridomas/*immunology ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 34
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    Crypts are the site of intestinal fluid and electrolyte secretion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-17
    Description: The site of adenosine 3',5'-monophosphate-mediated fluid and electrolyte secretion across mammalian large intestine was found to be the crypts of Lieberkuhn by means of two techniques. First, the formation of fluid droplets was visualized on the oil-covered mucosal surface directly over crypt duct openings when secretion was stimulated. Second, microelectrode impalement of individual surface and crypt cells revealed that only crypts cells produced a pattern of secretagogue induced alterations in membrane potential and resistance that was characteristic of secretory epithelia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Welsh, M J -- Smith, P L -- Fromm, M -- Frizzell, R A -- AM-27524/AM/NIADDK NIH HHS/ -- AM-31091/AM/NIADDK NIH HHS/ -- HL-07159/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Dec 17;218(4578):1219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6293054" target="_blank"〉PubMed〈/a〉
    Keywords: Amiloride/pharmacology ; Animals ; Chlorides/secretion ; Cyclic AMP/physiology ; In Vitro Techniques ; Intestine, Large/anatomy & histology/*physiology ; Prostaglandins E/pharmacology ; Rabbits ; Secretory Rate/drug effects ; Sodium/physiology ; *Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Substance P: a putative sensory transmitter in mammalian autonomic ganglia (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Repetitive presynaptic stimulation elicited slow membrane depolarization in neurons of inferior mesenteric ganglia from guinea pigs. This response was not blocked by cholinergic antagonists but was specifically and reversibly inhibited by a substance P analog, (D-Pro2, D-Phe7, D-Trp9)-substance P, which also depressed the depolarization induced by exogenously applied substance P. The atropine-sensitive slow excitatory and slow inhibitory postsynaptic potentials evoked in neurons of rabbit superior cervical ganglia were not affected by the substance P analog. These and previous results provide strong support for the hypothesis that substance P or a closely related peptide is the transmitter mediating the slow depolarization. The latter may represent a sensory input from the gastrointestinal tract to neurons of the prevertebral ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Z -- Dun, N J -- Karczmar, A G -- NS15848/NS/NINDS NIH HHS/ -- RR05368/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):739-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6179162" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Atropine/pharmacology ; Digestive System/physiopathology ; Ganglia, Autonomic/*drug effects ; Ganglia, Sympathetic/drug effects ; Gonadotropin-Releasing Hormone/pharmacology ; Guinea Pigs ; Membrane Potentials/drug effects ; Neurotransmitter Agents ; Peptides/*pharmacology ; Rabbits ; Substance P/analogs & derivatives/*physiology ; Tubocurarine/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 36
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    Cell biology yields clues to lung cancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):38-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289431" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma, Small Cell/*physiopathology ; Cell Division ; Cell Line ; Humans ; Lung Neoplasms/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 37
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    Control of vascular contractility by the cardiac pacemaker (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-26
    Description: Rhythmic contractile activity, synchronized with pulsatile pressure changes, was recorded from rabbit aorta in vivo. The contractions were locked in frequency to the pulsatile activity of the heart even when the heart was electrically paced to rates as high as 600 cycles per minute; termination of cardiac contractility resulted in their elimination. When the atria and ventricles contracted at different rates, the pulse-synchronized contractions were locked to the atrial rate. Excision of the right atrium, but not the left, resulted in the abolition of pulse-synchronized contractions. It is concluded that common pacemaker controls cardiac and vascular contractility, coordinating events in the two tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mangel, A -- Fahim, M -- van Breemen, C -- New York, N.Y. -- Science. 1982 Mar 26;215(4540):1627-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071582" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta/*physiology ; Heart/physiology ; Heart Rate ; Muscle Contraction ; Muscle, Smooth, Vascular/*physiology ; Myocardial Contraction ; Rabbits ; Sinoatrial Node/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    Impulse conduction in the mammalian brain: physiological properties of individual axons monitored for several months (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: Microelectrode recordings were used in conjunction with antidromic activation to monitor impulse conduction along individual mammalian cerebral axons for periods of up to 165 days. Approximately half of the axons studied showed a stable conduction velocity and stable aftereffects of impulse activity. The remaining axons showed slow and progressive increases or decreases in conduction velocity overtime. In these latter axons, changes in the magnitude of the aftereffects of impulse conduction were far less pronounced than were changes in axonal conduction velocity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swadlow, H A -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):911-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Brain/*physiology ; Neural Conduction ; Rabbits ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Oncogenes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, R E -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1069-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146895" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Mice ; *Oncogenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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