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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    DDC: 610.72
    Language: English
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  • 2
    Keywords: fractured reservoirs; hydrocarbon resources
    Description / Table of Contents: Advances in the study of naturally fractured hydrocarbon reservoirs: a broad integrated interdisciplinary applied topic / Guy H. Spence, Gary D. Couples, Tim G. Bevan, Roberto Aguilera, John W. Cosgrove, Jean-Marc Daniel and Jonathan Redfern / Geological Society, London, Special Publications, 374, 1-22, 9 July 2014, https://doi.org/10.1144/SP374.19 --- Investigating fracture networks using outcrop, core and geophysical data --- Sedimentological controls on the fracture distribution and network development in Mesaverde Group sandstone lithofacies, Uinta Basin, Utah, USA / Ryan Sonntag, James P. Evans, Paul La Pointe, Meagan Deraps, Hope Sisley and David Richey / Geological Society, London, Special Publications, 374, 23-50, 10 September 2012, https://doi.org/10.1144/SP374.4 --- Comparison of digital outcrop and conventional data collection approaches for the characterization of naturally fractured reservoir analogues / Thomas D. Seers and David Hodgetts / Geological Society, London, Special Publications, 374, 51-77, 19 April 2013, https://doi.org/10.1144/SP374.13 --- Fault linkage and damage zone architecture in tight carbonate rocks in the Suez Rift (Egypt): implications for permeability structure along segmented normal faults / A. Rotevatn and E. Bastesen / Geological Society, London, Special Publications, 374, 79-95, 10 September 2012, https://doi.org/10.1144/SP374.12 --- Quantifying fracture density and connectivity of fractured chalk reservoirs from core samples: implications for fluid flow / D. A. Sagi, M. Arnhild and J. F. Karlo / Geological Society, London, Special Publications, 374, 97-111, 26 June 2013, https://doi.org/10.1144/SP374.16 --- Characterizing discontinuities in naturally fractured outcrop analogues and rock core: the need to consider fracture development over geological time / S. R. Hencher / Geological Society, London, Special Publications, 374, 113-123, 9 May 2013, https://doi.org/10.1144/SP374.15 --- Numerical and statistical simulations and models --- What can we learn from high-resolution numerical simulations of single- and multi-phase fluid flow in fractured outcrop analogues? / Sebastian Geiger and Stephan Matthäi / Geological Society, London, Special Publications, 374, 125-144, 5 September 2012, https://doi.org/10.1144/SP374.8 --- Geomechanical impacts on flow in fractured reservoirs / Gary D. Couples / Geological Society, London, Special Publications, 374, 145-172, 25 June 2013, https://doi.org/10.1144/SP374.17 --- Geomechanical mechanisms involving faults and fractures for observed correlations between fluctuations in flowrates at wells in North Sea oilfields / Kes J. Heffer / Geological Society, London, Special Publications, 374, 173-186, 28 August 2012, https://doi.org/10.1144/SP374.2 --- Fluid flow through porous sandstone with overprinting and intersecting geological structures of various types / Xiaoxian Zhou, Mohammad Karimi-Fard, Louis J. Durlofsky and Atilla Aydin / Geological Society, London, Special Publications, 374, 187-209, 14 March 2013, https://doi.org/10.1144/SP374.11 --- Influences of nodular chert rhythmites on natural fracture networks in carbonates: an outcrop and two-dimensional discrete element modelling study / Guy H. Spence and Emma Finch / Geological Society, London, Special Publications, 374, 211-249, 7 March 2014, https://doi.org/10.1144/SP374.18 --- Sills as fractured hydrocarbon reservoirs: examples and models / Agust Gudmundsson and Ingrid F. Løtveit / Geological Society, London, Special Publications, 374, 251-271, 10 September 2012, https://doi.org/10.1144/SP374.5 --- A methodology to characterize fractured reservoirs constrained by statistical geological analysis and production: a real field case study / Matthieu Delorme, Rosane Oliveira Mota, Nina Khvoenkova, André Fourno and Benoit Nœtinger / Geological Society, London, Special Publications, 374, 273-288, 29 July 2013, https://doi.org/10.1144/SP374.14 --- Case studies --- Characterization of highly fractured basement, Say'un Masila Basin, Yemen / Ann Murray and David W. Montgomery / Geological Society, London, Special Publications, 374, 289-310, 27 July 2012, https://doi.org/10.1144/SP374.1 --- Characterizing seismic-scale faults pre- and post-drilling; Lewisian Basement, West of Shetlands, UK / Clare Slightam / Geological Society, London, Special Publications, 374, 311-331, 11 September 2012, https://doi.org/10.1144/SP374.6 --- Integration of outcrop and subsurface data during the development of a naturally fractured Eocene carbonate reservoir at the East Ras Budran concession, Gulf of Suez, Egypt / William Bosworth, Samir Khalil, Alan Clare, Joe Comisky, Hany Abdelal, Tom Reed and George Kokkoros / Geological Society, London, Special Publications, 374, 333-360, 31 July 2012, https://doi.org/10.1144/SP374.3 --- The Machar Oil Field, UK Central North Sea: impact of seismic reprocessing on the development of a complex fractured chalk field / M. V. Ward, C. Pearse, Y. Jehanno, M. O'Hanlon, A. Zett and D. Houliston / Geological Society, London, Special Publications, 374, 361-377, 17 October 2012, https://doi.org/10.1144/SP374.10 --- Dual-porosity fractured Miocene syn-rift dolomite reservoir in the Issaran Field (Gulf of Suez, Egypt): a case history of the zonal isolation of highly fractured water carrier bed / Ati Saoudi, Adel R. Moustafa, Ramadan I. Farag, Maher M. Omara, Hossam Wally, Ahmed Fouad, Amr Tag and Ramy Z. Ragab / Geological Society, London, Special Publications, 374, 379-394, 5 September 2012, https://doi.org/10.1144/SP374.7 --- The importance of natural fractures in a tight reservoir for potential CO2 storage: a case study of the upper Triassic–middle Jurassic Kapp Toscana Group (Spitsbergen, Arctic Norway) / K. Ogata, K. Senger, A. Braathen, J. Tveranger and S. Olaussen / Geological Society, London, Special Publications, 374, 395-415, 10 September 2012, https://doi.org/10.1144/SP374.9
    Pages: Online-Ressource (VI, 425 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781862396609
    Language: English
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  • 3
    Series available for loan
    Series available for loan
    Minneapolis, Minn. : Univ. of Minnesota Press
    Associated volumes
    Call number: SR 90.1041(45)
    In: Bulletin
    Type of Medium: Series available for loan
    Pages: XVI, 103 S.
    Series Statement: Bulletin / Minnesota Geological Survey 45
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 4
    Monograph available for loan
    Monograph available for loan
    London [u.a.] : Academic Press
    Call number: M 01.0058
    Type of Medium: Monograph available for loan
    Pages: xxiii, 663 S.
    ISBN: 0125309902
    Classification:
    C.3.7.
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 28 (1988), S. 311-329 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 1986-10-10
    Description: Vascular smooth muscle from different arteries of the rabbit varies in sensitivity to norepinephrine, even when factors known to contribute to this variation are excluded. Sensitivity to norepinephrine mediated through the alpha-adrenoceptor is linearly related to the agonist dissociation constant, but is not significantly related to receptor reserve. These results suggest that agonist affinity is the primary determinant of sensitivity to norepinephrine, at least in these arteries, and that this is a locally regulated characteristic which may account for regional sensitivity changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevan, J A -- Oriowo, M A -- Bevan, R D -- HL 32383/HL/NHLBI NIH HHS/ -- HL 32985/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):196-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteries ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/*drug effects/physiology ; Norepinephrine/*pharmacology ; Rabbits ; Receptors, Adrenergic, alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 1988-03-01
    Print ISSN: 0165-6147
    Electronic ISSN: 1873-3735
    Topics: Biology , Medicine
    Published by Cell Press
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  • 8
    Publication Date: 1977-12-01
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
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  • 9
    Publication Date: 2003-07-01
    Print ISSN: 1086-9379
    Electronic ISSN: 1945-5100
    Topics: Geosciences , Physics
    Published by Wiley
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  • 10
    Publication Date: 1988-04-01
    Print ISSN: 0362-1642
    Electronic ISSN: 1545-4304
    Topics: Chemistry and Pharmacology , Medicine
    Published by Annual Reviews
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