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  • 1
    Online Resource
    Online Resource
    Nuclear Receptors in Human Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    URL: https://doi.org/10.1007/978-3-031-11836-4
    DOI: 10.1007/978-3-031-11836-4
    DDC: 610.72
    Language: English
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  • 2
    Series available for loan
    Series available for loan
    Progressive contact metamorphism of the Biwabik Iron-formation, Mesabi range, Minnesota (1968)
    Minneapolis, Minn. : Univ. of Minnesota Press
    Associated volumes
    Details Availability
    Call number: SR 90.1041(45)
    In: Bulletin
    Type of Medium: Series available for loan
    Pages: XVI, 103 S.
    Series Statement: Bulletin / Minnesota Geological Survey 45
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 3
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    Advances in the Study of Fractured Reservoirs (2014)
    London : The Geological Society
    Details
    Keywords: fractured reservoirs; hydrocarbon resources
    Description / Table of Contents: Advances in the study of naturally fractured hydrocarbon reservoirs: a broad integrated interdisciplinary applied topic / Guy H. Spence, Gary D. Couples, Tim G. Bevan, Roberto Aguilera, John W. Cosgrove, Jean-Marc Daniel and Jonathan Redfern / Geological Society, London, Special Publications, 374, 1-22, 9 July 2014, https://doi.org/10.1144/SP374.19 --- Investigating fracture networks using outcrop, core and geophysical data --- Sedimentological controls on the fracture distribution and network development in Mesaverde Group sandstone lithofacies, Uinta Basin, Utah, USA / Ryan Sonntag, James P. Evans, Paul La Pointe, Meagan Deraps, Hope Sisley and David Richey / Geological Society, London, Special Publications, 374, 23-50, 10 September 2012, https://doi.org/10.1144/SP374.4 --- Comparison of digital outcrop and conventional data collection approaches for the characterization of naturally fractured reservoir analogues / Thomas D. Seers and David Hodgetts / Geological Society, London, Special Publications, 374, 51-77, 19 April 2013, https://doi.org/10.1144/SP374.13 --- Fault linkage and damage zone architecture in tight carbonate rocks in the Suez Rift (Egypt): implications for permeability structure along segmented normal faults / A. Rotevatn and E. Bastesen / Geological Society, London, Special Publications, 374, 79-95, 10 September 2012, https://doi.org/10.1144/SP374.12 --- Quantifying fracture density and connectivity of fractured chalk reservoirs from core samples: implications for fluid flow / D. A. Sagi, M. Arnhild and J. F. Karlo / Geological Society, London, Special Publications, 374, 97-111, 26 June 2013, https://doi.org/10.1144/SP374.16 --- Characterizing discontinuities in naturally fractured outcrop analogues and rock core: the need to consider fracture development over geological time / S. R. Hencher / Geological Society, London, Special Publications, 374, 113-123, 9 May 2013, https://doi.org/10.1144/SP374.15 --- Numerical and statistical simulations and models --- What can we learn from high-resolution numerical simulations of single- and multi-phase fluid flow in fractured outcrop analogues? / Sebastian Geiger and Stephan Matthäi / Geological Society, London, Special Publications, 374, 125-144, 5 September 2012, https://doi.org/10.1144/SP374.8 --- Geomechanical impacts on flow in fractured reservoirs / Gary D. Couples / Geological Society, London, Special Publications, 374, 145-172, 25 June 2013, https://doi.org/10.1144/SP374.17 --- Geomechanical mechanisms involving faults and fractures for observed correlations between fluctuations in flowrates at wells in North Sea oilfields / Kes J. Heffer / Geological Society, London, Special Publications, 374, 173-186, 28 August 2012, https://doi.org/10.1144/SP374.2 --- Fluid flow through porous sandstone with overprinting and intersecting geological structures of various types / Xiaoxian Zhou, Mohammad Karimi-Fard, Louis J. Durlofsky and Atilla Aydin / Geological Society, London, Special Publications, 374, 187-209, 14 March 2013, https://doi.org/10.1144/SP374.11 --- Influences of nodular chert rhythmites on natural fracture networks in carbonates: an outcrop and two-dimensional discrete element modelling study / Guy H. Spence and Emma Finch / Geological Society, London, Special Publications, 374, 211-249, 7 March 2014, https://doi.org/10.1144/SP374.18 --- Sills as fractured hydrocarbon reservoirs: examples and models / Agust Gudmundsson and Ingrid F. Løtveit / Geological Society, London, Special Publications, 374, 251-271, 10 September 2012, https://doi.org/10.1144/SP374.5 --- A methodology to characterize fractured reservoirs constrained by statistical geological analysis and production: a real field case study / Matthieu Delorme, Rosane Oliveira Mota, Nina Khvoenkova, André Fourno and Benoit Nœtinger / Geological Society, London, Special Publications, 374, 273-288, 29 July 2013, https://doi.org/10.1144/SP374.14 --- Case studies --- Characterization of highly fractured basement, Say'un Masila Basin, Yemen / Ann Murray and David W. Montgomery / Geological Society, London, Special Publications, 374, 289-310, 27 July 2012, https://doi.org/10.1144/SP374.1 --- Characterizing seismic-scale faults pre- and post-drilling; Lewisian Basement, West of Shetlands, UK / Clare Slightam / Geological Society, London, Special Publications, 374, 311-331, 11 September 2012, https://doi.org/10.1144/SP374.6 --- Integration of outcrop and subsurface data during the development of a naturally fractured Eocene carbonate reservoir at the East Ras Budran concession, Gulf of Suez, Egypt / William Bosworth, Samir Khalil, Alan Clare, Joe Comisky, Hany Abdelal, Tom Reed and George Kokkoros / Geological Society, London, Special Publications, 374, 333-360, 31 July 2012, https://doi.org/10.1144/SP374.3 --- The Machar Oil Field, UK Central North Sea: impact of seismic reprocessing on the development of a complex fractured chalk field / M. V. Ward, C. Pearse, Y. Jehanno, M. O'Hanlon, A. Zett and D. Houliston / Geological Society, London, Special Publications, 374, 361-377, 17 October 2012, https://doi.org/10.1144/SP374.10 --- Dual-porosity fractured Miocene syn-rift dolomite reservoir in the Issaran Field (Gulf of Suez, Egypt): a case history of the zonal isolation of highly fractured water carrier bed / Ati Saoudi, Adel R. Moustafa, Ramadan I. Farag, Maher M. Omara, Hossam Wally, Ahmed Fouad, Amr Tag and Ramy Z. Ragab / Geological Society, London, Special Publications, 374, 379-394, 5 September 2012, https://doi.org/10.1144/SP374.7 --- The importance of natural fractures in a tight reservoir for potential CO2 storage: a case study of the upper Triassic–middle Jurassic Kapp Toscana Group (Spitsbergen, Arctic Norway) / K. Ogata, K. Senger, A. Braathen, J. Tveranger and S. Olaussen / Geological Society, London, Special Publications, 374, 395-415, 10 September 2012, https://doi.org/10.1144/SP374.9
    Pages: Online-Ressource (VI, 425 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781862396609
    URL: https://sp.lyellcollection.org/content/374/1
    Language: English
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  • 4
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    The Physics of the B Factories (2021)
    Springer Nature
    Details
    Publication Date: 2024-04-04
    Description: Physics
    Keywords: Physics ; bic Book Industry Communication::P Mathematics & science::PH Physics ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 5
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    The Physics of the B Factories (2021)
    Springer Nature
    Details
    Publication Date: 2024-04-04
    Description: This comprehensive work thoroughly introduces and reviews the set of results from Belle and BaBar - after more than two decades of independent and complementary work - all the way from the detectors and the analysis tools used, up to the physics results, and the interpretation of these results. The world’s two giant B Factory collaborations, Belle at KEK and BaBar at SLAC, have successfully completed their main mission to discover and quantify CP violation in the decays of B mesons. CP violation is a necessary requirement to distinguish unambiguously between matter and antimatter. The shared primary objective of the two B Factory experiments was to determine the shape of the so-called unitarity triangle, an abstract triangle representing interactions of quarks, the elementary constituents of matter. The area of the triangle is a measure of the amount of CP violation associated with the weak force. Many other measurements have been performed by the B Factories and are also discussed in this work.
    Keywords: QC1-999 ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: English
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  • 6
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    How Did Britain Come to This? (2023)
    LSE Press
    Details
    Publication Date: 2023-11-17
    Description: If every system is perfectly designed to get the results it gets, what is wrong with the design of the systems that govern Britain? And how have they resulted in failures in housing, privatisation, outsourcing, education and healthcare? In How Did Britain Come to This? Gwyn Bevan examines a century of varieties of systemic failures in the British state. The book begins and ends by showing how systems of governance explain scandals in NHS hospitals, and the failures and successes of the UK and Germany in responding to Covid-19 before and after vaccines became available. The book compares geographical fault lines and inequalities in Britain with those that have developed in other European countries and argues that the causes of Britain’s entrenched inequalities are consequences of shifts in systems of governance over the past century. Clement Attlee’s postwar government aimed to remedy the failings of the prewar minimal state, while Margaret Thatcher’s governments in the 1980s in turn sought to remedy the failings of Attlee’s planned state by developing the marketised state, which morphed into the financialised state we see today. This analysis highlights the urgent need for a new political settlement of an enabling state that tackles current systemic weaknesses from market failures and over-centralisation. This book offers an accessible, analytic account of government failures of the past century, and is essential reading for anyone who wants to make an informed contribution to what an innovative, capable state might look like in a post-pandemic world.
    Keywords: British politics; Public policy; Governance ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::A The arts::AM Architecture::AMG Public buildings: civic, commercial, industrial, etc
    Language: English
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  • 7
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    Validation And Comparison Of Ice Velocity Fields From SAR Data Results Of The ESA Glaciers_CCI Round Robin Experiment (2013)
    In:  Proceedings
    Details
    Publication Date: 2020-03-19
    Description: Ice velocity is an important parameter to evaluate the dynamic response of glaciers to climate change. Repeat pass SAR data enable the measuring of ice motion with high accuracy through differential processing techniques, including SAR interferometry and offset tracking. In order to validate and inter-compare ice velocity maps generated by various techniques at different institutions, Round Robin Exercises were initiated in the frame of the ESA Glacier Climate Change Initiative (CCI) project. Standardised datasets (SAR and optical repeat pass satellite scenes) were prepared for three different test sites. The participants were invited to select a data set, apply their software/technique of choice for ice flow mapping, and return the results together with a feedback form describing the processing steps and selected parameters in detail. Here we summarise the results of the comparisons only for the SAR data sets over three test sites.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 8
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    Sensitivity of Neoproterozoic Snowball-Earth inceptions to continental configuration, orbital geometry, and volcanism (2023)
    In:  Climate of the Past
    Details
    Publication Date: 2023-12-15
    Description: The Cryogenian period (720–635 million years ago) in the Neoproterozoic era featured two phases of global or near-global ice cover, termed ‘Snowball Earth’. Climate models of all kinds indicate that the inception of these phases must have occurred in the course of a self-amplifying ice–albedo feedback that forced the climate from a partially ice-covered to a Snowball state within a few years or decades. The maximum concentration of atmospheric carbon dioxide (CO₂) allowing such a drastic shift depends on the choice of model, the boundary conditions prescribed in the model, and the amount of climatic variability. Many previous studies report values or ranges for this CO₂ threshold but typically test only very few different boundary conditions or exclude variability due to volcanism. Here we present a comprehensive sensitivity study determining the CO₂ threshold in different scenarios for the Cryogenian continental configuration, orbital geometry, and short-term volcanic cooling effects in a consistent model framework, using the climate model of intermediate complexity CLIMBER-3α. The continental configurations comprise two palaeogeographic reconstructions for each of both Snowball-Earth onsets, as well as two idealised configurations with either uniformly dispersed continents or a single polar supercontinent. Orbital geometries are sampled as multiple different combinations of the parameters obliquity, eccentricity, and argument of perihelion. For volcanic eruptions, we differentiate between single globally-homogeneous perturbations, single zonally-resolved perturbations, and random sequences of globally-homogeneous perturbations with realistic statistics. The CO₂ threshold lies between 10 and 250 ppm for all simulations. While the idealised continental configurations span a difference of around 200 ppm for the threshold, the CO₂ thresholds for the continental reconstructions differ by only 20–40 ppm. Changes in orbital geometry account for variations in the CO₂ threshold by up to 32 ppm. The effects of volcanic perturbations largely depend on the orbital geometry and the corresponding structure of coexisting stable states. A very large peak reduction of net solar radiation by around 20 W m⁻² can shift the CO₂ threshold by the same order of magnitude as or less than the orbital geometry. Exceptionally large eruptions of up to −40 W m⁻² shift the threshold by up to 50 ppm for one orbital configuration. Eruptions near the equator tend to, but do not always, cause larger shifts than eruptions at high latitudes. The effect of realistic eruption sequences is mostly determined by their largest events. In the presence of particularly intense small-magnitude volcanism, this effect can go beyond the ranges expected from single eruptions.
    Language: English
    Type: info:eu-repo/semantics/article
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