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  • 1
    Electronic Resource
    Electronic Resource
    Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1057-1058 
    Details
    ISSN: 1420-9071
    Keywords: Acetylcholine ; endothelium-dependent vasodilation ; resistance vessel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Isolated resistance vessels in the rabbit ear preconstricted with histamine were relaxed by acetylcholine by a proportionately greater amount than the central ear artery. The relaxation was antagonized by atropine and also by endothelium removal. Our studies represent the first direct evidence that endothelium-dependent dilation can occur in resistance vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952142
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of inulin space in the rabbit thoracic aorta (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 55-56 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die ganze Länge und Dicke des extrazellulären Raumes der thorakalen Kaninchenaorta wurde gemessen. Der Raum ist unverändert die ganze Länge des Blutgefässes hindurch und entspricht 0,59 ml/g 0,39 ml/g für die Adventitia und die Media. In jeder dieser Tunicae ist der Raum durch ihre ganze Dicke gleichmässig verteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02137738
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of novel Tapasin polymorphisms and linkage disequilibrium to MHC class I alleles (2000)
    Springer
    Immunogenetics 52 (2000), S. 9-11 
    Details
    ISSN: 1432-1211
    Keywords: Tapasin Polymorphism MHC class I Intron Haplotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Tapasin is a M r 48,000 glycoprotein and has a specialized role in MHC class I-restricted antigen presentation. It is encoded by a gene which maps centromeric to the MHC class II region of human Chromosome 6 within 200 kb of HLA-DP. There is variable dependence upon tapasin for MHC class I expression among different MHC class I alleles. HLA-B*4402 and to a lesser extent HLA-A1 and B8 are tapasin dependent, whereas HLA-B27, A2 and to a lesser extent B7 and A3 are tapasin independent. We investigated whether tapasin is polymorphic and whether these Tapasin alleles are in linkage with any MHC class I alleles. We identified three new mutations within intron 4, which are in a particular linkage with the previously described exon 4 (G16003C) dimorphism. The intronic mutations are G16146T, G16232A, and T16317A (numbering according to cosmid clone F0811; GenBank accession number Z97184). The allele frequency of Tapasin*01 (G16003) was 0.47 and Tapasin*02 (C16003) was 0.53 in this UK population. Four of the eight possible intronic haplotypes were identified and their cis linkage with the tapasin dimorphism ascertained. Tapasin*01 was associated with all the identified haplotypes, while Tapasin*02 was only associated with the wild-type intronic sequence (GGT). There was no significant linkage (P〉0.01) of the Tapasin dimorphism or new Tapasin alleles to any of the MHC class I A, B, or C alleles studied or to the extended A1 B8 DR3 haplotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510000244
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  • 4
    Electronic Resource
    Electronic Resource
    H-2 restriction of cytolysis after immunization of minorH congenic pairs of mice (1976)
    Springer
    Immunogenetics 3 (1976), S. 177-184 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mice of three congenic resistant lines differing from C57BL/10 at theH-3, H-13, H-7, andH-8 minor histocompatibility loci were used to immunize, and were immunized with, C57BL/10. Cytotoxic cells which were capable of causing rapid lysis of cells from the immunizing strain were generated at least one-way in all combinations tested. In order for a target to be susceptible to cytolysis, it had to carry both the sameH-2 b haplotype and the same differential minor histocompatibility alleles as the immunizing strain. That is, B10.C(47N) (H-2 b ,H-7 b ) anti-C57BL/10 (H-2 b ,H-7 a ) cytotoxic cells lysed C57BL/10 targets but not B10.BR (H-2 k ,H-7 a ) targets, nor BALB.B (H-2 b ,H-7 b ) targets. Crossreactions in the cytotoxic assay suggest that theH-3, H-13 congenic pair —B10.LP and C57BL/10 —may differ in at least two more minor histocompatibility loci which have not yet been defined. Although 6 x 1066 C57BL/10 lymphoid cells primed B10.D2(57N) (H-8 b ) mice for a secondary in vitro cytotoxic response, a tenfold higher dose apparently made them tolerant. It is concluded that all minor histocompatibility differences can generate cytotoxic T cells which show specificity both for the minor and major histocompatibility alleles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576949
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  • 5
    Electronic Resource
    Electronic Resource
    Immunoselection of structural H-2Kb variants: Use of cloned cytolytic T cells to select for loss of a CTL-defined allodeterminant (1986)
    Springer
    Immunogenetics 23 (1986), S. 52-59 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Functional studies concerning the unique interaction between class I H-2 allodeterminants and cytolytic T lymphocyte (CTL) antigen receptors have benefitted from the development of H-2Kb mutant mouse strains and somatic H-2 variants selected with monoclonal antibody. Here, we describe the development of a novel approach to immunoselection of somatic H-2Kb variants employing a Kb-specific CTL clone as the negative selective agent. The rationale for this method is that the use of an alloreactive CTL clone as the selective agent should enable us to detect the emergence of structural Kb variants based on their loss of the relevant CTL-defined allodeterminant. Thus, these structural variants are well suited to an in-depth analysis of the functional relationship between H-2 antigens and receptor recognition by CTL. Using this approach, we successfully isolated two types of structural Kb variants, as well as numerous Kb-loss variants. The functional studies described in this paper indicate that these structural variants exhibit alterations in expression of both CTL-defined and serologically defined H-2Kb allodeterminants. The structural characterization of such variants should enable us to identify the precise amino acid residues responsible for the creation of the relevant CTL-defined Kb allodeterminants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376522
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of the Qa-4 allodeterminant (1985)
    Springer
    Immunogenetics 21 (1985), S. 511-516 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430934
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  • 7
    Electronic Resource
    Electronic Resource
    The ability of H-2+ and H-2− cell lines to induce or be lysed by Cytotoxic T cells (1977)
    Springer
    Immunogenetics 4 (1977), S. 7-16 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have studied the T cell-mediated lysis of two C58 lymphoma lines: R1(TL+), which bears serologically detectable H-2k and TL1,2,3 antigens, and R1(TL−), an immunoselected variant which lacks these antigens. Unlike R1(TL+) cells, the variant cells are not sensitive to specific lysis by T cells directed against either H-2k or minor H antigens of C58 mice. An injection of R1(TL+) cells into allogeneic H-2-identical or H-2-different mice primes for an excellent secondary cytotoxic response in vitro to R1(TL+); but not to R1(TL−). Immunization in vivo and in vitro with R1(TL)−) leads to little or no priming or generation of cytotoxic T cells. Both cell lines, however, are sensitive to nonspecific lysis by cytotoxic cells in the presence of PHA or Con A, although even under these conditions, R1(TL+) is killed more effectively than is R1(TL−). We conclude that R1(TL−) does not express any form of H-2 antigen which can be detected by immunization or by sensitivity to cytotoxic T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575642
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  • 8
    Electronic Resource
    Electronic Resource
    Sub-Doppler excited molecule energy transfer spectroscopy (1982)
    Springer
    Applied physics 27 (1982), S. 153-156 
    Details
    ISSN: 1432-0649
    Keywords: 33 ; 42.80 ; 07.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A sub-Doppler spectroscopic technique involving the detection of vibrational energy transfer in excited molecules with selected velocity components at a microphone diaphragm is demonstrated. The technique is applied to the investigation of thev 3 R(16) transition in HCN and the results compared with a previously derived theoretical model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00694641
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  • 9
    Electronic Resource
    Electronic Resource
    New FIR laser lines from optically pumped DCOF (1983)
    Springer
    Applied physics 30 (1983), S. 1-4 
    Details
    ISSN: 1432-0649
    Keywords: 33 ; 42.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Twenty FIR laser lines with wavelengths between 146 and 2000 μm have been observed from deuterated formyl fluoride (DCOF) optically pumped with isotopic CO2 lasers. Tunable diode laser measurements on thev 4 band of DCOF were combined with earlier high precision spectroscopic data on thev 3 andv 4 bands, and enabled identification of the transitions responsible for 9 of the new FIR lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692650
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  • 10
    Electronic Resource
    Electronic Resource
    1H and 15N NMR studies of protonation and hydrogen-bonding in the binding of trimethoprim to dihydrofolate reductase (1985)
    Springer
    European biophysics journal 11 (1985), S. 211-218 
    Details
    ISSN: 1432-1017
    Keywords: Dihydrofolate reductase ; trimethoprim ; NMR (15N, 1H) ; hydrogen bonding ; protonation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The binding of trimethoprim and [1,3,2-amino-15N3]-trimethoprim to Lactobacillus casei dihydrofolate reductase has been studied by 15N and 1H NMR spectroscopy. 15N NMR spectra of the bound drug were obtained by using polarisation transfer pulse sequences. The 15N chemical shifts and 1H-15N spin-coupling constants show unambiguously that the drug is protonated on N1 when bound to the enzyme. The N1-proton resonance in the complex has been assigned using the 15N-enriched molecule. The temperature-dependence of the linewidth of this resonance has been used to estimate the rate of exchange of this proton with the solvent: 160±10s-1 at 313 K, with an activation energy of 75 (±9) kJ·mole-1. This is considerably faster than the dissociation rate of the drug from this complex, demonstrating that there are local fluctuations in the structure of the complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261997
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