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  • 11
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    Tracking hydrocarbon plume transport and biodegradation at Deepwater Horizon (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-21
    Description: The Deepwater Horizon blowout is the largest offshore oil spill in history. We present results from a subsurface hydrocarbon survey using an autonomous underwater vehicle and a ship-cabled sampler. Our findings indicate the presence of a continuous plume of oil, more than 35 kilometers in length, at approximately 1100 meters depth that persisted for months without substantial biodegradation. Samples collected from within the plume reveal monoaromatic petroleum hydrocarbon concentrations in excess of 50 micrograms per liter. These data indicate that monoaromatic input to this plume was at least 5500 kilograms per day, which is more than double the total source rate of all natural seeps of the monoaromatic petroleum hydrocarbons in the northern Gulf of Mexico. Dissolved oxygen concentrations suggest that microbial respiration rates within the plume were not appreciably more than 1 micromolar oxygen per day.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Camilli, Richard -- Reddy, Christopher M -- Yoerger, Dana R -- Van Mooy, Benjamin A S -- Jakuba, Michael V -- Kinsey, James C -- McIntyre, Cameron P -- Sylva, Sean P -- Maloney, James V -- New York, N.Y. -- Science. 2010 Oct 8;330(6001):201-4. doi: 10.1126/science.1195223. Epub 2010 Aug 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Applied Ocean Physics and Engineering Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. rcamilli@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20724584" target="_blank"〉PubMed〈/a〉
    Keywords: Atlantic Ocean ; Bacteria/*metabolism ; *Biodegradation, Environmental ; *Environmental Pollution ; *Hydrocarbons/metabolism ; *Petroleum/metabolism ; *Seawater/chemistry/microbiology ; *Water Pollutants/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Crystal structure of human adenovirus at 3.5 A resolution (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-08-28
    Description: Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom resolution of the 150-megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions between the major capsid protein (hexon) and several accessory molecules that stabilize the capsid. The virus structure also reveals an altered association between the penton base and the trimeric fiber protein, perhaps reflecting an early event in cell entry. The high-resolution structure provides a substantial advance toward understanding the assembly and cell entry mechanisms of a large double-stranded DNA virus and provides new opportunities for improving adenovirus-mediated gene transfer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929978/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929978/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, Vijay S -- Natchiar, S Kundhavai -- Stewart, Phoebe L -- Nemerow, Glen R -- AI042929/AI/NIAID NIH HHS/ -- EY011431/EY/NEI NIH HHS/ -- HL054352/HL/NHLBI NIH HHS/ -- R01 AI070771/AI/NIAID NIH HHS/ -- R01 AI070771-03/AI/NIAID NIH HHS/ -- R01 EY011431/EY/NEI NIH HHS/ -- R01 EY011431-13/EY/NEI NIH HHS/ -- R01 HL054352/HL/NHLBI NIH HHS/ -- R01 HL054352-17/HL/NHLBI NIH HHS/ -- R29 AI042929/AI/NIAID NIH HHS/ -- R29 AI042929-06/AI/NIAID NIH HHS/ -- Y1-CO-1020/CO/NCI NIH HHS/ -- Y1-GM-1104/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1071-5. doi: 10.1126/science.1187292.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. reddyv@scripps.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20798318" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/*chemistry/physiology/*ultrastructure ; Capsid/*chemistry/*ultrastructure ; Capsid Proteins/*chemistry/ultrastructure ; Crystallography, X-Ray ; Genetic Vectors ; Hydrogen Bonding ; Models, Molecular ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits/chemistry ; Virus Internalization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 13
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    Spontaneous ferroelectric order in a bent-core smectic liquid crystal of fluid orthorhombic layers (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-02
    Description: Macroscopic polarization density, characteristic of ferroelectric phases, is stabilized by dipolar intermolecular interactions. These are weakened as materials become more fluid and of higher symmetry, limiting ferroelectricity to crystals and to smectic liquid crystal stackings of fluid layers. We report the SmAP(F), the smectic of fluid polar orthorhombic layers that order into a three-dimensional ferroelectric state, the highest-symmetry layered ferroelectric possible and the highest-symmetry ferroelectric material found to date. Its bent-core molecular design employs a single flexible tail that stabilizes layers with untilted molecules and in-plane polar ordering, evident in monolayer-thick freely suspended films. Electro-optic response reveals the three-dimensional orthorhombic ferroelectric structure, stabilized by silane molecular terminations that promote parallel alignment of the molecular dipoles in adjacent layers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, R Amaranatha -- Zhu, Chenhui -- Shao, Renfan -- Korblova, Eva -- Gong, Tao -- Shen, Yongqiang -- Garcia, Edgardo -- Glaser, Matthew A -- Maclennan, Joseph E -- Walba, David M -- Clark, Noel A -- New York, N.Y. -- Science. 2011 Apr 1;332(6025):72-7. doi: 10.1126/science.1197248.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, Liquid Crystal Materials Research Center, University of Colorado, Boulder, CO 80309-0215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21454782" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Color and albedo heterogeneity of Vesta from Dawn (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-05-15
    Description: Multispectral images (0.44 to 0.98 mum) of asteroid (4) Vesta obtained by the Dawn Framing Cameras reveal global color variations that uncover and help understand the north-south hemispherical dichotomy. The signature of deep lithologies excavated during the formation of the Rheasilvia basin on the south pole has been preserved on the surface. Color variations (band depth, spectral slope, and eucrite-diogenite abundance) clearly correlate with distinct compositional units. Vesta displays the greatest variation of geometric albedo (0.10 to 0.67) of any asteroid yet observed. Four distinct color units are recognized that chronicle processes--including impact excavation, mass wasting, and space weathering--that shaped the asteroid's surface. Vesta's color and photometric diversity are indicative of its status as a preserved, differentiated protoplanet.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reddy, Vishnu -- Nathues, Andreas -- Le Corre, Lucille -- Sierks, Holger -- Li, Jian-Yang -- Gaskell, Robert -- McCoy, Timothy -- Beck, Andrew W -- Schroder, Stefan E -- Pieters, Carle M -- Becker, Kris J -- Buratti, Bonnie J -- Denevi, Brett -- Blewett, David T -- Christensen, Ulrich -- Gaffey, Michael J -- Gutierrez-Marques, Pablo -- Hicks, Michael -- Keller, Horst Uwe -- Maue, Thorsten -- Mottola, Stefano -- McFadden, Lucy A -- McSween, Harry Y -- Mittlefehldt, David -- O'Brien, David P -- Raymond, Carol -- Russell, Christopher -- New York, N.Y. -- Science. 2012 May 11;336(6082):700-4. doi: 10.1126/science.1219088.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute for Solar System Research, Max-Planck-Strasse 2, 37191 Katlenburg-Lindau, Germany. reddy@mps.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22582258" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 15
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    Science and law. When scientific research and legal practice collide (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Camilli, R -- Bowen, A -- Reddy, C M -- Seewald, J S -- Yoerger, D R -- New York, N.Y. -- Science. 2012 Sep 28;337(6102):1608-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Applied Ocean Physics and Engineering Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. rcamilli@whoi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23019634" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/adverse effects ; Chemical Industry/*legislation & jurisprudence ; Disasters/prevention & control ; Drug Industry/*legislation & jurisprudence ; Expert Testimony/legislation & jurisprudence ; Research/*legislation & jurisprudence ; Tetrachlorodibenzodioxin/adverse effects ; United States ; United States Environmental Protection Agency/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Elemental mapping by Dawn reveals exogenic H in Vesta's regolith (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-09-22
    Description: Using Dawn's Gamma Ray and Neutron Detector, we tested models of Vesta's evolution based on studies of howardite, eucrite, and diogenite (HED) meteorites. Global Fe/O and Fe/Si ratios are consistent with HED compositions. Neutron measurements confirm that a thick, diogenitic lower crust is exposed in the Rheasilvia basin, which is consistent with global magmatic differentiation. Vesta's regolith contains substantial amounts of hydrogen. The highest hydrogen concentrations coincide with older, low-albedo regions near the equator, where water ice is unstable. The young, Rheasilvia basin contains the lowest concentrations. These observations are consistent with gradual accumulation of hydrogen by infall of carbonaceous chondrites--observed as clasts in some howardites--and subsequent removal or burial of this material by large impacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Prettyman, Thomas H -- Mittlefehldt, David W -- Yamashita, Naoyuki -- Lawrence, David J -- Beck, Andrew W -- Feldman, William C -- McCoy, Timothy J -- McSween, Harry Y -- Toplis, Michael J -- Titus, Timothy N -- Tricarico, Pasquale -- Reedy, Robert C -- Hendricks, John S -- Forni, Olivier -- Le Corre, Lucille -- Li, Jian-Yang -- Mizzon, Hugau -- Reddy, Vishnu -- Raymond, Carol A -- Russell, Christopher T -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):242-6. doi: 10.1126/science.1225354. Epub 2012 Sep 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Planetary Science Institute, 1700 East Fort Lowell, Suite 106, Tucson, AZ 85719-2395, USA. prettyman@psi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22997135" target="_blank"〉PubMed〈/a〉
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  • 17
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    Physiology. Rhythmic respiration (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-02
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768352/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768352/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rey, Guillaume -- Reddy, Akhilesh B -- 100333/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Nov 1;342(6158):570-1. doi: 10.1126/science.1246658.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24179212" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Circadian Clocks/*physiology ; *Energy Metabolism ; Mitochondria, Liver/*metabolism ; NAD/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Virus sharing, genetic sequencing, and global health security (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-09-13
    Description: This Perspective focuses on the future of the Pandemic Influenza Preparedness (PIP) Framework, which was initially established to promote the fair sharing of public health-related pandemic influenza samples between countries. We examine the changes that need to be made to address the growing likelihood that genetic sequence data might be shared instead of physical virus samples, as well as the need to expand the PIP framework's scope and to improve its fairness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gostin, Lawrence O -- Phelan, Alexandra -- Stoto, Michael A -- Kraemer, John D -- Reddy, K Srinath -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1295-6. doi: 10.1126/science.1257622.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC 20001, USA. ; Department of Health Systems Administration, Georgetown University, Washington, DC 20057, USA. ; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC 20001, USA. Department of Health Systems Administration, Georgetown University, Washington, DC 20057, USA. ; President, Public Health Foundation of India, New Delhi 110070, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214618" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disaster Planning ; *Global Health ; Health Services Accessibility ; Humans ; Influenza A Virus, H1N1 Subtype/*genetics ; Influenza A Virus, H5N1 Subtype/*genetics ; *Influenza Vaccines ; Influenza in Birds/epidemiology/prevention & control ; Influenza, Human/epidemiology/*prevention & control/virology ; Intellectual Property ; Orthomyxoviridae Infections/prevention & control/virology ; Pandemics/*prevention & control/veterinary ; Poultry ; Sequence Analysis, DNA ; Swine
    Print ISSN: 0036-8075
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  • 19
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    Two abundant bioaccumulated halogenated compounds are natural products (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-02-12
    Description: Methoxylated polybrominated diphenyl ethers (MeO-PBDEs) have been found bioaccumulated in the tissues of a variety of aquatic animals and at concentrations comparable to those of anthropogenic halogenated organic compounds, including polychlorinated biphenyls (PCBs). The origin of the MeO-PBDEs has been uncertain; circumstantial evidence supports a natural and/or an industrial source. By analyzing the natural abundance radiocarbon content of two MeO-PBDEs isolated from a True's beaked whale (Mesoplodon mirus), we show that these compounds were naturally produced.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teuten, Emma L -- Xu, Li -- Reddy, Christopher M -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):917-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705850" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*chemistry/metabolism ; Animals ; Anisoles/*analysis/chemistry/isolation & purification/metabolism ; Biotransformation ; Carbon Radioisotopes/analysis ; Diet ; Environmental Exposure ; Hydroxylation ; Methylation ; Molecular Structure ; Phenyl Ethers/*analysis/chemistry/isolation & purification/metabolism ; Polybrominated Biphenyls/*analysis/chemistry/isolation & purification/metabolism ; Whales/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Reconstructing the origin of Andaman Islanders (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-05-14
    Description: The origin of the Andaman "Negrito" and Nicobar "Mongoloid" populations has been ambiguous. Our analyses of complete mitochondrial DNA sequences from Onges and Great Andaman populations revealed two deeply branching clades that share their most recent common ancestor in founder haplogroup M, with lineages spread among India, Africa, East Asia, New Guinea, and Australia. This distribution suggests that these two clades have likely survived in genetic isolation since the initial settlement of the islands during an out-of-Africa migration by anatomically modern humans. In contrast, Nicobarese sequences illustrate a close genetic relationship with populations from Southeast Asia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thangaraj, Kumarasamy -- Chaubey, Gyaneshwer -- Kivisild, Toomas -- Reddy, Alla G -- Singh, Vijay Kumar -- Rasalkar, Avinash A -- Singh, Lalji -- New York, N.Y. -- Science. 2005 May 13;308(5724):996.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Cellular and Molecular Biology, Hyderabad-500 007, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890876" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Asia ; Asia, Southeastern ; Chromosomes, Human, Y/genetics ; DNA, Mitochondrial/*genetics ; Emigration and Immigration ; Ethnic Groups/*genetics ; Founder Effect ; Genetic Drift ; Genetics, Population ; Geography ; Haplotypes ; Humans ; India ; Mutation ; Phylogeny ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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