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  • 1
    Publication Date: 2013-04-19
    Description: Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown or overexpression, have led to the widespread use of zebrafish in the detailed investigation of vertebrate gene function and increasingly, the study of human genetic disease. However, for effective modelling of human genetic disease it is important to understand the extent to which zebrafish genes and gene structures are related to orthologous human genes. To examine this, we generated a high-quality sequence assembly of the zebrafish genome, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map. Detailed automatic and manual annotation provides evidence of more than 26,000 protein-coding genes, the largest gene set of any vertebrate so far sequenced. Comparison to the human reference genome shows that approximately 70% of human genes have at least one obvious zebrafish orthologue. In addition, the high quality of this genome assembly provides a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebrafish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703927/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703927/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, Kerstin -- Clark, Matthew D -- Torroja, Carlos F -- Torrance, James -- Berthelot, Camille -- Muffato, Matthieu -- Collins, John E -- Humphray, Sean -- McLaren, Karen -- Matthews, Lucy -- McLaren, Stuart -- Sealy, Ian -- Caccamo, Mario -- Churcher, Carol -- Scott, Carol -- Barrett, Jeffrey C -- Koch, Romke -- Rauch, Gerd-Jorg -- White, Simon -- Chow, William -- Kilian, Britt -- Quintais, Leonor T -- Guerra-Assuncao, Jose A -- Zhou, Yi -- Gu, Yong -- Yen, Jennifer -- Vogel, Jan-Hinnerk -- Eyre, Tina -- Redmond, Seth -- Banerjee, Ruby -- Chi, Jianxiang -- Fu, Beiyuan -- Langley, Elizabeth -- Maguire, Sean F -- Laird, Gavin K -- Lloyd, David -- Kenyon, Emma -- Donaldson, Sarah -- Sehra, Harminder -- Almeida-King, Jeff -- Loveland, Jane -- Trevanion, Stephen -- Jones, Matt -- Quail, Mike -- Willey, Dave -- Hunt, Adrienne -- Burton, John -- Sims, Sarah -- McLay, Kirsten -- Plumb, Bob -- Davis, Joy -- Clee, Chris -- Oliver, Karen -- Clark, Richard -- Riddle, Clare -- Elliot, David -- Threadgold, Glen -- Harden, Glenn -- Ware, Darren -- Begum, Sharmin -- Mortimore, Beverley -- Kerry, Giselle -- Heath, Paul -- Phillimore, Benjamin -- Tracey, Alan -- Corby, Nicole -- Dunn, Matthew -- Johnson, Christopher -- Wood, Jonathan -- Clark, Susan -- Pelan, Sarah -- Griffiths, Guy -- Smith, Michelle -- Glithero, Rebecca -- Howden, Philip -- Barker, Nicholas -- Lloyd, Christine -- Stevens, Christopher -- Harley, Joanna -- Holt, Karen -- Panagiotidis, Georgios -- Lovell, Jamieson -- Beasley, Helen -- Henderson, Carl -- Gordon, Daria -- Auger, Katherine -- Wright, Deborah -- Collins, Joanna -- Raisen, Claire -- Dyer, Lauren -- Leung, Kenric -- Robertson, Lauren -- Ambridge, Kirsty -- Leongamornlert, Daniel -- McGuire, Sarah -- Gilderthorp, Ruth -- Griffiths, Coline -- Manthravadi, Deepa -- Nichol, Sarah -- Barker, Gary -- Whitehead, Siobhan -- Kay, Michael -- Brown, Jacqueline -- Murnane, Clare -- Gray, Emma -- Humphries, Matthew -- Sycamore, Neil -- Barker, Darren -- Saunders, David -- Wallis, Justene -- Babbage, Anne -- Hammond, Sian -- Mashreghi-Mohammadi, Maryam -- Barr, Lucy -- Martin, Sancha -- Wray, Paul -- Ellington, Andrew -- Matthews, Nicholas -- Ellwood, Matthew -- Woodmansey, Rebecca -- Clark, Graham -- Cooper, James D -- Tromans, Anthony -- Grafham, Darren -- Skuce, Carl -- Pandian, Richard -- Andrews, Robert -- Harrison, Elliot -- Kimberley, Andrew -- Garnett, Jane -- Fosker, Nigel -- Hall, Rebekah -- Garner, Patrick -- Kelly, Daniel -- Bird, Christine -- Palmer, Sophie -- Gehring, Ines -- Berger, Andrea -- Dooley, Christopher M -- Ersan-Urun, Zubeyde -- Eser, Cigdem -- Geiger, Horst -- Geisler, Maria -- Karotki, Lena -- Kirn, Anette -- Konantz, Judith -- Konantz, Martina -- Oberlander, Martina -- Rudolph-Geiger, Silke -- Teucke, Mathias -- Lanz, Christa -- Raddatz, Gunter -- Osoegawa, Kazutoyo -- Zhu, Baoli -- Rapp, Amanda -- Widaa, Sara -- Langford, Cordelia -- Yang, Fengtang -- Schuster, Stephan C -- Carter, Nigel P -- Harrow, Jennifer -- Ning, Zemin -- Herrero, Javier -- Searle, Steve M J -- Enright, Anton -- Geisler, Robert -- Plasterk, Ronald H A -- Lee, Charles -- Westerfield, Monte -- de Jong, Pieter J -- Zon, Leonard I -- Postlethwait, John H -- Nusslein-Volhard, Christiane -- Hubbard, Tim J P -- Roest Crollius, Hugues -- Rogers, Jane -- Stemple, Derek L -- 095908/Wellcome Trust/United Kingdom -- 098051/Wellcome Trust/United Kingdom -- 1 R01 DK55377-01A1/DK/NIDDK NIH HHS/ -- P01 HD022486/HD/NICHD NIH HHS/ -- P01 HD22486/HD/NICHD NIH HHS/ -- R01 GM085318/GM/NIGMS NIH HHS/ -- R01 OD011116/OD/NIH HHS/ -- R01 RR010715/RR/NCRR NIH HHS/ -- R01 RR020833/RR/NCRR NIH HHS/ -- England -- Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23594743" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes/genetics ; Conserved Sequence/*genetics ; Evolution, Molecular ; Female ; Genes/genetics ; Genome/*genetics ; Genome, Human/genetics ; Genomics ; Humans ; Male ; Meiosis/genetics ; Molecular Sequence Annotation ; Pseudogenes/genetics ; Reference Standards ; Sex Determination Processes/genetics ; Zebrafish/*genetics ; Zebrafish Proteins/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-05-22
    Description: We report the discovery of KELT-10b, the first transiting exoplanet discovered using the KELT-South telescope. KELT-10b is a highly inflated sub-Jupiter mass planet transiting a relatively bright V = 10.7 star (TYC 8378-64-1), with T eff = 5948 ± 74 K, log g = $4.319_{-0.030}^{+0.020}$ and [Fe/H] = $0.09_{-0.10}^{+0.11}$ , an inferred mass M * = $1.112_{-0.061}^{+0.055}$ M and radius R * = $1.209_{-0.035}^{+0.047}$ R . The planet has a radius R p = $1.399_{-0.049}^{+0.069}$ R J and mass M p = $0.679_{-0.038}^{+0.039}$ M J . The planet has an eccentricity consistent with zero and a semimajor axis a = $0.052\,50_{-0.000\,97}^{+0.000\,86}$ au. The best-fitting linear ephemeris is T 0 = 2457 066.720 45 ± 0.000 27 BJD TDB and P = 4.166 2739 ± 0.000 0063 d. This planet joins a group of highly inflated transiting exoplanets with a larger radius and smaller mass than that of Jupiter. The planet, which boasts deep transits of 1.4 per cent, has a relatively high equilibrium temperature of T eq = $1377_{-23}^{+28}$  K, assuming zero albedo and perfect heat redistribution. KELT-10b receives an estimated insolation of $0.817_{-0.054}^{+0.068}$ x 10 9  erg s –1  cm –2 , which places it far above the insolation threshold above which hot Jupiters exhibit increasing amounts of radius inflation. Evolutionary analysis of the host star suggests that KELT-10b may not survive beyond the current subgiant phase, depending on the rate of in-spiral of the planet over the next few Gyr. The planet transits a relatively bright star and exhibits the third largest transit depth of all transiting exoplanets with V 〈 11 in the Southern hemisphere, making it a promising candidate for future atmospheric characterization studies.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    BioEssays 14 (1992), S. 385-393 
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Flounders Pleuronectes flesus with an implanted vascular catheter were exposed to a 50% dilution of the water soluble fraction (WSF) of Omani crude oil (c. 6ppm total aromatic hydrocarbons) and serial blood samples taken to determine their endocrine status (cortisol, catecholamines and thyroid hormones) and the resultant and/or causal physiological (haematological, ionoregulatory and respiratory) disturbances. This resulted in a progressive increase in plasma cortisol concentrations from 3 h onwards (rising from 18 to 51 ng ml−1 after 48-h exposure), and increased plasma glucose concentrations indicating a generalized stress response. Plasma T3 and T4 concentrations of both control and WSF-exposed groups declined progressively over the experimental period; exposure to the WSF of crude oil further depressed plasma T4 concentrations but not plasma T3 concentrations relative to those of control fish. Plasma osmolality and sodium and chloride concentrations were stable in WSF-exposed fish, however, plasma potassium concentrations were increased significantly at the 24-and 48-h sampling points. The most profound physiological disturbance in WSF-exposed fish was a dramatic decline in blood oxygen content (CvO2) (from 2–8 to 0–8 ml 100 ml−1 after 48-h exposure), which is likely to be the cause of the increased plasma noradrenaline concentrations from 3 h onwards. Increased noradrenaline is likely in turn to have been responsible for the significant increase in blood haematocrit and blood haemoglobin at the 3-h sampling point, although the dominant effect in the longer-term was a significant decline in both of these haematological parameters.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2012-08-01
    Description: The high-grade Flying Fox komatiite-hosted Ni sulfide deposit, located in the Forrestania greenstone belt of the Archean Yilgarn Craton, Western Australia, is hosted in a deformed and metamorphosed volcano-metasedimentary succession. Postmineralization events have sheared and modified the texture and composition of the original massive sulfide ore, creating up to 11 distinct ore shoots including massive, stringer/vein, and breccia sulfides composed of pyrrhotite, pentlandite, chalcopyrite, and variable abundances of pyrite ranging up to 40 vol %. Nickel and platinum group elements (PGE) tenor variations were investigated in two ore shoots, T4 and T5. All mineralization styles show considerable variability in Ni tenor. PGEs show strong linear correlations between Ir, Os, Ru, and Rh, but poor correlation between Pt, Pd, and Cu. The normalized molar proportions of Fe, Ni, and S, projected into the Fe-Ni-S ternary system, show a distinct linear trend of pyrite addition to a typical primary magmatic composition and no correlation with mineralization style. The high pyrite content present throughout the Flying Fox ore is also associated with elevated Cu and As contents and is interpreted to be primarily due to the addition of pyrite from circulating Fe-, S-, Cu-, and As-enriched fluids creating pyrite-pentlandite intergrowths. Localized mechanical segregation of pyrite, sulfidation of pyrrhotite to pyrite, and oxidation of pyrrhotite to pyrite + magnetite has also contributed to these increased pyrite contents, although to a lesser extent. The addition and segregation of pyrite has diluted the Ni tenor, with no evidence to suggest chemical mobilization of Ni.
    Print ISSN: 0361-0128
    Topics: Geosciences
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  • 7
    Publication Date: 2012-11-01
    Description: The Flying Fox komatiite-hosted Ni deposit is located in the Forrestania greenstone belt of the Yilgarn craton in Western Australia. The host volcanosedimentary succession has been metamorphosed to amphibolite facies and deformation has sheared and dismembered the orebody, creating 11 distinct ore shoots. The ore shoots are hosted at the base of a komatiite sequence structurally overlying deformed metasedimentary rocks. The Ni sulfide orebody has undergone six phases of deformation: (1) D 1aReg : E-W compression resulted in tilting of the stratigraphy, (2) D 1bFF : continued E-W compression resulted in coaxial flattening along the footwall sedimentary rock-sulfide/komatiite contact and the basalt-hanging-wall sedimentary rock contact, (3) D 2FF : ENE-WSW compression resulted in noncoaxial shearing of the D 1bFF structures, (4) D 3FF : ESE-WNW compression resulted in shallow-angle thrusts, (5) D 4FF : during E-W extension, normal ductile-brittle faults formed by the pooling and dilation of granitic magma along the F 2 structural contact between the footwall sedimentary and komatiite rocks, and (6) D 5FF : intrusion of a Proterozoic dolerite dike during N-S extension accompanied by late-stage brittle normal faulting. During deformation the Ni sulfides reverted to monosulfide solid solution (MSS) and were mechanically relocated along the footwall sedimentary rock-komatiite contact, offset into the footwall sedimentary rocks, and entrained in the granitic magma, creating atypical granite-hosted sulfides. The Ni sulfides were mobilized up to 5 m away from the ultramafic rocks during the D 1 and D 2 events; however, subsequent dismemberment of the original orebody into separate ore shoots along flat-lying faults during the D 3 event led to offsets of up to 300 m. The detailed structural analysis of the Flying Fox deposit has shown that restoration of the lithostratigraphy along known faults can be used to define the volcanic stratigraphy, including primary Ni ore horizons. This information can be used as a guide to the location of concealed extensions to known ore shoots or completely unknown orebodies at depth or along strike.
    Print ISSN: 0361-0128
    Topics: Geosciences
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  • 8
    Publication Date: 2012-12-19
    Description: We report a group of optical imaging probes, comprising upconverting lanthanide nanoparticles (UCNPs) and polyanionic dendrimers. Dendrimers with rigid cores and multiple carboxylate groups at the periphery are able to tightly bind to surfaces of UCNPs pretreated with NOBF4, yielding stable, water-soluble, biocompatible nanomaterials. Unlike conventional linear polymers, dendrimers adhere...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2011-01-04
    Description: We report a one-pot chemical approach for the synthesis of highly monodisperse colloidal nanophosphors displaying bright upconversion luminescence under 980 nm excitation. This general method optimizes the synthesis with initial heating rates up to 100 °C/minute generating a rich family of nanoscale building blocks with distinct morphologies (spheres, rods, hexagonal prisms, and plates) and upconversion emission tunable through the choice of rare earth dopants. Furthermore, we employ an interfacial assembly strategy to organize these nanocrystals (NCs) into superlattices over multiple length scales facilitating the NC characterization and enabling systematic studies of shape-directed assembly. The global and local ordering of these superstructures is programmed by the precise engineering of individual NC’s size and shape. This dramatically improved nanophosphor synthesis together with insights from shape-directed assembly will advance the investigation of an array of emerging biological and energy-related nanophosphor applications.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2011-08-24
    Description: The meridional distribution of NO(x) in the lower stratosphere and upper troposphere is inferred form 10 flights of the NASA DC-8 in the northern winter of 1992 along with like distributions of NO(y), NO(x)/NO(y), CO, and C2Cl4. In the lowest few km of the stratosphere there is little vertical gradient in NO(x) over the range of latitiudes measured (40 deg-90 deg N). There is a substantial latitudinal gradient, with 50 pptv above the pole and 120 pptv near 40 deg N. In the uppermost few km of the troposphere, background values range from 30 pptv over the pole to 90 pptv near 40 deg N. On two occasions higher values, up to 140 pptv in the mean, were seen 2-3 km below the tropopause in association with frontal systems. The meridional distributions of CO and C2Cl4 show the same feature, suggesting that the source of the elevated NO(x) is near the earth's system.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 21; 23; p. 2583-2586
    Format: text
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