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  • International Union of Crystallography  (175)
  • American Association for the Advancement of Science (AAAS)  (93)
  • American Physical Society (APS)
  • 1995-1999  (268)
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Year
  • 1
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    In vivo endoscopic optical biopsy with optical coherence tomography (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-27
    Description: Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as "optical biopsy," was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tearney, G J -- Brezinski, M E -- Bouma, B E -- Boppart, S A -- Pitris, C -- Southern, J F -- Fujimoto, J G -- NIH-1-R29-HL55686-01A1/HL/NHLBI NIH HHS/ -- NIH-9-RO1-EY11289/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1997 Jun 27;276(5321):2037-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Electrical Engineering and Computer Science, Building 36-357, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9197265" target="_blank"〉PubMed〈/a〉
    Keywords: Anatomy, Cross-Sectional ; Animals ; Biopsy ; Catheterization/instrumentation ; Endoscopes ; Epithelium/anatomy & histology ; Esophagoscopes ; Esophagus/*anatomy & histology/blood supply ; Fiber Optic Technology ; Interferometry/instrumentation ; Lasers ; Mucous Membrane/anatomy & histology ; Rabbits ; Scattering, Radiation ; Tomography/instrumentation/*methods ; Trachea/*anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    In situ observations of a high-pressure phase of H2O Ice (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-08-07
    Description: A previously unknown solid phase of H2O has been identified by its peculiar growth patterns, distinct pressure-temperature melting relations, and vibrational Raman spectra. Morphologies of ice crystals and their pressure-temperature melting relations were directly observed in a hydrothermal diamond-anvil cell for H2O bulk densities between 1203 and 1257 kilograms per cubic meter at temperatures between -10 degrees and 50 degreesC. Under these conditions, four different ice forms were observed to melt: two stable phases, ice V and ice VI, and two metastable phases, ice IV and the new ice phase. The Raman spectra and crystal morphology are consistent with a disordered anisotropic structure with some similarities to ice VI.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chou -- Blank -- Goncharov -- Mao -- Hemley -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):809-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉I. Chou, 955 National Center, U.S. Geological Survey, Reston, VA 20192, USA. J. G. Blank, A. F. Goncharov, H. Mao, R. J. Hemley, Geophysical Laboratory and Center for High Pressure Research, Carnegie Institution of Washington, 5251 Broad.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9694649" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-06
    Description: The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild-type allele, COI1, was mapped to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie, D X -- Feys, B F -- James, S -- Nieto-Rostro, M -- Turner, J G -- New York, N.Y. -- Science. 1998 May 15;280(5366):1091-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9582125" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates/pharmacology ; Amino Acid Sequence ; Arabidopsis/*genetics/growth & development/physiology ; *Arabidopsis Proteins ; Chromosome Mapping ; Cyclopentanes/*metabolism/pharmacology ; *Genes, Plant ; Genetic Complementation Test ; Molecular Sequence Data ; Mutation ; Open Reading Frames ; Oxylipins ; Plant Growth Regulators/*metabolism ; Plant Proteins/chemistry/*genetics/*physiology ; Plants, Genetically Modified ; Polymorphism, Genetic ; Repressor Proteins/metabolism ; Signal Transduction ; Transformation, Genetic ; Ubiquitins/metabolism
    Print ISSN: 0036-8075
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  • 4
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    Knowing where and getting there: a human navigation network (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-05-23
    Description: The neural basis of navigation by humans was investigated with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town. Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between them. Getting to those places quickly was strongly associated with activation of the right caudate nucleus. These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigation. These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maguire, E A -- Burgess, N -- Donnett, J G -- Frackowiak, R S -- Frith, C D -- O'Keefe, J -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 May 8;280(5365):921-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK. e.maguire@fil.ion.ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9572740" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Mapping ; Caudate Nucleus/blood supply/*physiology/radionuclide imaging ; Cues ; Frontal Lobe/blood supply/*physiology/radionuclide imaging ; Hippocampus/blood supply/*physiology/radionuclide imaging ; Humans ; Male ; Memory ; Neural Pathways ; *Orientation ; Parietal Lobe/blood supply/*physiology/radionuclide imaging ; Psychomotor Performance ; Regional Blood Flow ; *Space Perception ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Physician-scientists: staying alive (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perpich, J G -- New York, N.Y. -- Science. 1999 Apr 23;284(5414):591-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10328741" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; *Education, Graduate ; Education, Medical, Graduate ; Fellowships and Scholarships ; *Physicians ; *Research ; *Research Personnel ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-29
    Description: A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expulsion of the side chain upon opening of the beta-lactam ring retained antibacterial activity while safely expelling the immunodominant epitope. L-786,392 was well tolerated in animal safety studies and had significant in vitro and in vivo activities against methicillin- and vancomycin-resistant Staphylococci and vancomycin-resistant Enterococci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosen, H -- Hajdu, R -- Silver, L -- Kropp, H -- Dorso, K -- Kohler, J -- Sundelof, J G -- Huber, J -- Hammond, G G -- Jackson, J J -- Gill, C J -- Thompson, R -- Pelak, B A -- Epstein-Toney, J H -- Lankas, G -- Wilkening, R R -- Wildonger, K J -- Blizzard, T A -- DiNinno, F P -- Ratcliffe, R W -- Heck, J V -- Kozarich, J W -- Hammond, M L -- New York, N.Y. -- Science. 1999 Jan 29;283(5402):703-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Merck Research Laboratories, Rahway, NJ 07065, USA. hugh_rosen@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9924033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/blood ; *Bacterial Proteins ; Carbapenems/chemistry/*immunology/metabolism/*pharmacology/toxicity ; Carrier Proteins/metabolism ; Dipeptidases/metabolism ; *Drug Design ; Drug Resistance, Microbial ; Drug Resistance, Multiple ; Enterococcus/drug effects ; Erythrocytes/immunology ; Haptens ; *Hexosyltransferases ; Humans ; Immunodominant Epitopes ; Immunoglobulin G/blood ; Lactams/chemical synthesis/chemistry/metabolism/*pharmacology ; Lymphocyte Activation ; Macaca mulatta ; Mice ; Mice, Inbred DBA ; Microbial Sensitivity Tests ; Muramoylpentapeptide Carboxypeptidase/metabolism ; Penicillin-Binding Proteins ; *Peptidyl Transferases ; Staphylococcal Infections/drug therapy ; Staphylococcus/drug effects ; Thiazoles/chemical synthesis/chemistry/metabolism/*pharmacology
    Print ISSN: 0036-8075
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  • 7
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    Principles for Sustainable Governance of the Oceans (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-11
    Description: Pressures being exerted on the ocean ecosystems through overfishing, pollution, and environmental and climate change are increasing. Six core principles are proposed to guide governance and use of ocean resources and to promote sustainability. Examples of governance structures that embody these principles are given.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costanza -- Andrade -- Antunes -- den Belt M -- Boersma -- Boesch -- Catarino -- Hanna -- Limburg -- Low -- Molitor -- Pereira -- Rayner -- Santos -- Wilson -- Young -- New York, N.Y. -- Science. 1998 Jul 10;281(5374):198-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉R. Costanza, Univ. of Maryland Center for Environmental Science, Biology Dept., and Inst. for Ecological Economics, P.O. Box 38, Solomons, MD 20688, USA. F. Andrade, Marine Laboratory of Guia, Sciences Faculty of Lisbon Univ. (FCUL), Estrada do Guincho, 2750 Cascais, Portugal. P. Antunes and R. Santos, Ecoman Center, Dept. of Environmental Sciences and Engineering, New University of Lisbon, Quinta da Torre, 2825 Monte da Caparica, Portugal. M. van den Belt, Ecological Economics Research and Applications, Inc., P.O. Box 1589, Solomons, MD 20688, USA. D. Boersma, Dept. of Zoology, Univ. of Washington, Seattle, WA 98195, USA. D. Boesch, Univ. of Maryland Center for Environmental Science, P.O. Box 775, Cambridge, MD 21613, USA. F. Catarino, Faculty of Sciences, Univ. of Lisbon, Rua Escola Politecnica, 58, 1250 Lisbon, Portugal. S. Hanna, Dept. of Agricultural and Resource Economics, Oregon State Univ., Corvalis, OR 97331-3601, USA. K. Limburg, Dept. of Systems Ecology, Univ. of Stockholm, S-106 91 Stockholm, Sweden. B. Low, School of Natural Resources, Univ. of Michigan, Ann Arbor MI 48109-1115, USA. M. Molitor, Dept. of Earth and Environmental Sciences, Columbia Univ., P.O. Box 689, Oracle, AZ 85623, USA. J. G. Pereira, Dept. of Oceanography and Fisheries, Univ. of the Azores, PT 9900 Horta, Azores, Portugal. S. Rayner, Battelle, 901 D Street SW, Suite 900, Washington, DC 20024-2115, USA. J. Wilson, School of Marine Sciences, Univ. of Maine, Orono, ME 04469-5741, USA. M. Young, CSIRO Land and Water, Private Bag No. 2, Glen Osmond, Australia 5064.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9660740" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 8
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    Net primary production of a forest ecosystem with experimental CO2 enrichment (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-15
    Description: The concentration of atmospheric carbon dioxide was increased by 200 microliters per liter in a forest plantation, where competition between organisms, resource limitations, and environmental stresses may modulate biotic responses. After 2 years the growth rate of the dominant pine trees increased by about 26 percent relative to trees under ambient conditions. Carbon dioxide enrichment also increased litterfall and fine-root increment. These changes increased the total net primary production by 25 percent. Such an increase in forest net primary production globally would fix about 50 percent of the anthropogenic carbon dioxide projected to be released into the atmosphere in the year 2050. The response of this young, rapidly growing forest to carbon dioxide may represent the upper limit for forest carbon sequestration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DeLucia -- Hamilton -- Naidu -- Thomas -- Andrews -- Finzi -- Lavine -- Matamala -- Mohan -- Hendrey -- Schlesinger -- New York, N.Y. -- Science. 1999 May 14;284(5417):1177-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biology, University of Illinois, Urbana, IL 61801, USA. Department of Biology, West Virginia University, Morgantown, WV 26506, USA. Department of Botany, Institute of Statistics and Decision Science, Duke Universi.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10325230" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 9
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    Regulation of chamber-specific gene expression in the developing heart by Irx4 (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-02-19
    Description: The vertebrate heart consists of two types of chambers, the atria and the ventricles, which differ in their contractile and electrophysiological properties. Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois-related homeobox gene, Irx4, was identified that has a ventricle-restricted expression pattern at all stages of heart development. Irx4 protein was shown to regulate the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (VMHC1) and suppressing the expression of the atrial myosin heavy chain-1 (AMHC1) in the ventricles. Thus, Irx4 may play a critical role in establishing chamber-specific gene expression in the developing heart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bao, Z Z -- Bruneau, B G -- Seidman, J G -- Seidman, C E -- Cepko, C L -- New York, N.Y. -- Science. 1999 Feb 19;283(5405):1161-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10024241" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; *Atrial Myosins ; *Avian Proteins ; Chick Embryo ; *Gene Expression Regulation, Developmental ; Heart Atria/*embryology/metabolism/virology ; Heart Ventricles/*embryology/metabolism/virology ; Homeodomain Proteins/chemistry/genetics/*physiology ; In Situ Hybridization ; Molecular Sequence Data ; Muscle Proteins/*genetics ; Myosin Heavy Chains/genetics ; Myosins/*genetics ; Phenotype ; Recombinant Fusion Proteins ; Retroviridae/genetics/physiology
    Print ISSN: 0036-8075
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  • 10
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    Visualization of specific B and T lymphocyte interactions in the lymph node (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-04
    Description: Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garside, P -- Ingulli, E -- Merica, R R -- Johnson, J G -- Noelle, R J -- Jenkins, M K -- AI27998/AI/NIAID NIH HHS/ -- AI35296/AI/NIAID NIH HHS/ -- AI39614/AI/NIAID NIH HHS/ -- Wellcome Trust/United Kingdom -- etc. -- New York, N.Y. -- Science. 1998 Jul 3;281(5373):96-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9651253" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Animals ; *Antibody Formation ; Antigen Presentation ; B-Lymphocytes/cytology/*immunology ; CD4-Positive T-Lymphocytes/cytology/*immunology ; CD40 Ligand ; Cell Movement ; Dendritic Cells/immunology ; Germinal Center/immunology ; Immunization ; Immunoglobulin M/analysis ; Lymph Nodes/cytology/*immunology ; *Lymphocyte Activation ; Membrane Glycoproteins/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Plasma Cells/immunology
    Print ISSN: 0036-8075
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