Publication Date:
1998-07-04
Description:
Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garside, P -- Ingulli, E -- Merica, R R -- Johnson, J G -- Noelle, R J -- Jenkins, M K -- AI27998/AI/NIAID NIH HHS/ -- AI35296/AI/NIAID NIH HHS/ -- AI39614/AI/NIAID NIH HHS/ -- Wellcome Trust/United Kingdom -- etc. -- New York, N.Y. -- Science. 1998 Jul 3;281(5373):96-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9651253" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
*Antibody Formation
;
Antigen Presentation
;
B-Lymphocytes/cytology/*immunology
;
CD4-Positive T-Lymphocytes/cytology/*immunology
;
CD40 Ligand
;
Cell Movement
;
Dendritic Cells/immunology
;
Germinal Center/immunology
;
Immunization
;
Immunoglobulin M/analysis
;
Lymph Nodes/cytology/*immunology
;
*Lymphocyte Activation
;
Membrane Glycoproteins/immunology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Plasma Cells/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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