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  • Chemistry  (425)
  • Animals  (24)
  • 2005-2009  (14)
  • 2000-2004  (6)
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  • 1980-1984  (159)
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  • 1
    Electronic Resource
    Electronic Resource
    Übergangsmetall-Carben-Komplexe, CXXVII. Kinetische und mechanistische Untersuchungen von Übergangsmetall-Komplex-Reaktionen, XIII. Diethylamino(phenyltelluro)carben- und Diethylaminocarbin-(phenyltelluro)-Komplexe des Chroms: Präparative Untersuchungen und Kinetik der C, Cr-Wanderung von PhTe (1983)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 116 (1983), S. 1009-1016 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Transition Metal Carbene Complexes, CXXVII. Kinetic and Mechanistic Investigations of Transition Metal Complex Reactions, XI11 2. Diethylamino(phenyltel1uro)carbene- and Diethylaminocarbyne(phenyltelluro) Complexes of Chromium: Preparative Investigations and Kinetics of the C, Cr-Migration of PhTePentacarbonyl(diethylaminocarbyne)chromium tetrafluoroborate, [(CO)5CrCNEt2]BF4 (1), reacts with lithium tellurophenolate, Li[TePh], with addition of the tellurophenolate anion to the carbyne carbon atom to give pentacarbonyl[diethylamino(phenyltelluro)carbene]chromium, (CO)5Cr[C(TePh)NEt2] (2). On heating in solution, the complex 2 rearranges with CO-elimination and C, Cr-migration of TePh to give trans-tetracarbonyl(diethylaminocarbyne)(phenyltelluro)chromium, trans-(PhTe)(CO)4CrCNEt2 (3). The rearrangement follows a first order rate law (-d[2]/dt = k[2]; ΔH≠ = 108 ± 1 kJmol-1; ΔS≠ = 42 ± 4 Jmol-1K-1; in 1,1,2-trichloroethane). In solution, 3 dimerizes with CO-elimination to give bis(μ-phenyltelluro)-bis[tricarbonyl(diethylaminocarbyne)chromium], (μ-PhTe)2[(CO)3CrCNEt2]2 (4). Addition of PPh3 to solutions of 2 does not influence the rate of the rearrangement but leads to a different product, mer-(PhTe)(CO)3(PPh3)CrCNEt2 (5).
    Notes: Pentacarbonyl(diethylaminocarbin)chrom-tetrafluoroborat, [(CO)5CrCNEt2]BF4 (1), reagiert mit Lithium-tellurophenolat, Li[TePh], unter Addition des Tellurophenolat-Anions an das Carbin-kohlenstoffatom und Bildung von Pentacarbonyl[diethylamino(phenyltelluro)carben]chrom, (CO)5Cr[C(TePh)NEt2] (2). Beim Erwärmen in Lösung lagert sich der Komplex 2 unter CO-Abspaltung und C, Cr-Wanderung von TePh nach einem Geschwindigkeitsgesetz erster Ordnung (-d[2]/dt = k[2]; ΔH≠ = 108 ± 1 kJmol-1; ΔS≠ = Jmol-1K-1; in 1,1,2-Trichlorethan) zu trans-Tetracarbonyl(diethylaminocarbin)(phenyltelluro)chrom, trans-(PhTe)(CO)4-CrCNEt2 (3), um. In Lösung dimerisiert 3 unter CO-Eliminierung zu Bis(μ-phenyltelluro)-bis[tricarbonyl(diethylaminocarbin)chrom], (μ-PhTe)2[(CO)3CrCNEt2]2 (4). Zusatz von PPh3 zu Lösungen von 2 beeinflußt zwar die Umlagerungsgeschwindigkeit nicht, liefert jedoch als Reaktionsprodukt mer-(PhTe)(CO)3(PPh3)CrCNEt2 (5).
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19831160318
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  • 2
    Electronic Resource
    Electronic Resource
    P/O Ligand Systems: Facile Synthesis, Structure, and Catalytic Tests of 2′-Phosphanyl-1,1′ -phenyl-2-ols and 2′-Phosphanyl-1,1′-binaphthyl-2-ols (1997)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 130 (1997), S. 1663-1670 
    Details
    ISSN: 0009-2940
    Keywords: Lithiation ; P ligands ; NMR spectroscopy ; Molecular structure ; Hydrogenations ; Hydroformylations ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A facile synthesis of 2′-phosphanyl-1,1′-biphenyl- and 2′-phosphanyl-1,1′ -binaphthyl-2-ols and their silyl ethers has been developed, consisting of electron-transfer-catalyzed ring-opening of dibenzofuran and dinaphthofuran, respectively, subsequent reaction with chlorophosphanes, and work-up with acetic acid or ClSiMe3. Studies of the molecular and crystal structures reveals the presence of P - H - O bridging bonds in the more basic tBuPhP derivative and a nearly perpendicular arrangement of the aryl planes in the biphenyl derivatives. The barrier to rotation of the aryl planes about the C-C axis was determined by NMR in the case of the P-asymmetric derivative 3d, using the appearence of diastereoisomers by atropisomerism and P-asymmetry. Comparative screening tests of the title compounds, phosphanyl phenols and phosphanylnaphthols in homogeneous Rh-catalyzed reactions demonstrate catalytic activity in hydroformylation reactions and superior properties of the biphenyl- and binaphthyl-2-ol derivatives in relation to other P-O ligands.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19971301118
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  • 3
    Electronic Resource
    Electronic Resource
    Übergangsmetall-Carben-Komplexe, CXXII. Kinetische und mechanistische Untersuchungen von übergangsmetall-Komplex-Reaktionen, XII. Pentacarbonyl[diethylamino(triphenylplumbyl)carben]chrom und trans-Tetracarbonyl(diethylaminocarbin)(triphenyl-plumbyl)chrom: Präparative Untersuchungen und Kinetik der C,Cr-Wanderung von PbPh3 (1982)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 115 (1982), S. 2707-2713 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Transition Metal Carbene Complexes, CXXII. Kinetic and Mechanistic Investigations of Transition Metal Complex Reaction, XII. Pentacarbonyl[diethylamino(triphenylplumbyl)carbene]chromium and trans-Tetracarbonyl(diethylaminocarbyne)(triphenylplumbyl)chromium: Preparative Investigations and Kinetics of the C,Cr-Migration of PbPh3Pentacarbonyl(diethylaminocarbyne)chromium tetrafluoroborate, [(CO)5CrCNEt2]BF4 (2), reacts with lithium triphenylplumbate, LiPbPh3 (3), with addition of the plumbate anion to the carbyne carbon atom to give pentacarbonyl[diethylamino(triphenylplumbyl)carbene]chromium, (CO)5-Cr[C(PbPh3)NEt2] (4). Already at room temperature, the complex 4 rearranges with CO-elimination and C,Cr-migration of PbPh3 to give trans-tetracarbonyl(diethylaminocarbyne)(triphenylplumbyl)chromium, trans-(Ph3Pb)(CO)4CrNEt2 (5). The rearrangement follows a first-order rate law (ΔH≠ = 103 kJmol-1; ΔS≠ = 40 Jmol-1, K-1, in 1,1,2-trichloroethane). The compounds 4 und 5 were characterized by analytical and spectroscopic means.
    Notes: Pentacarbonyl(diethylaminocarbin)chrom-tetrafluoroborat, [(CO)5CrCNEt2]BF4 (2), reagiert mit Lithium-triphenylplumbat, LiPbPh3 (3), unter Addition des Plumbat-Anions an das Carbinkohlenstoffatom und Bildung von Pentacarbonyl[diethylamino(triphenylplumbyl)carben]chrom, (CO)5Cr[C(PbPh3)NEt2] (4). Bereits bei Raumtemperatur lagert sich der Komplex 4 unter CO-Abspaltung und C,Cr-Wanderung von PbPh3 nach einem Geschwindigkeitsgesetz erster Ordnung (ΔH≠ = 103 kJmol-1, ΔS≠ = 40 Jmol-1, K-1, in 1,1,2-Trichlorethan) zu trans-Tetracarbonyl-(diethylaminocarbin)(triphenylplumbyl)chrom, trans-(Ph3Pb)(CO)4CrCNEt2 (5), um. Die Verbindungen 4 und 5 wurden analytisch und spektroskopisch gesichert.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19821150804
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  • 4
    Electronic Resource
    Electronic Resource
    Übergangsmetall-Carben-Komplexe, CXVII1) [(Arylseleno)(diethylamino)carben]pentacarbonylchrom(0)-Komplexe (1981)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3209-3219 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Transition Metal Carbene Complexes, CXVII1) [(Arylseleno)(diethylamino)carbene]pentacarbonylchromium(0)Pentacarbonyl(diethylaminocarbyne)chromium tetrafluoroborate, [CO)5CrCNEt2]BF4, (1) reacts with lithium arylselenolate, LiSeR, (3) [R = 4-C6H4CF3 (a), 4-C6H4Br (b) 4-C6H4F (c), C6H5 (d), 4-C6H4CH3 (e), 4-C6H4OCH3 (f), 1-C10H7 (g)] with addition of the selenolate anion to the carbyne carbon atom to give [(arylseleno)(diethylamino)carbene]pentacarbonylchromium(0), (CO)5Cr[C(SeR)NEt2], (4a - g). The complexes 4 were characterized by elemental analyses, spectroscopic data and in the case fo 4d additionally by an X-ray analysis. On heating in solution, 4a - g rearrange with CO-elimination and C,Cr-migration of SeR to the corresponding trans-(arylseleno)tetracarbonyl(diethylaminocarbyne)chromium complexes, trans-RSe(CO)4-CrCNEt2, (5a - g).
    Notes: Pentacarbonyl(diethylaminocarbin)chrom-tetrafluoroborat, [(CO)5CrCNEt2]BF4, (1) reagiert mit Lithium -arylselenolat, LiSeR, (3) [R = 4-C6H4CF3 (a), 4-C6H4Br (b) 4-C6H4 (c), C6H5 (d), 4-C6H4CH3 (e), 4-C6H4OCH3 (f), 1-C10H7 (g)] unter Addition des Selenolat-Anions an das Carbinkohlenstoffatom und Bildung von [Arylseleno)(diethylamino)carben]pentacarbonylchrom(0), (CO)5Cr[C(SeR)NEt2], (4a-g). Die Komplexe 4 wurden elementaranalytisch, spektroskopisch sowie im Fall von 4d zusätzlich durch eine Röntgenstrukturanalyse gesichert. Beim Erwärmen in Lösung lagern sich 4a-g unter CO-Abspaltung und C, Cr-Wanderung von SeR zu den entsprechenden trans-(Arylseleno)tetracarbonyl(diethylaminocarbin)chrom-Komplexen, trans-RSe(CO)4(CrCNEt2, (5a-g) um.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19811141003
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  • 5
    Electronic Resource
    Electronic Resource
    Übergangsmetall-Carben-Komplexe, CXVIII1) Kinetische und mechanistische Untersuchungen von Übergangsmetall-Komplex-Reaktionen, VIII2) C, Cr-Wanderung von SeR in (CO)5Cr[C(SeR)NEt2]: Kinetische, mechanistische und präparative Untersuchungen (1981)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3220-3232 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Transition Metal Carbene Complexes, CXVIII1) Kinetic and Mechanistic Investigations of Transition Metal Complex Reactions, VIII2) C, Cr-Migration of SeR in (CO)5Cr[C(SeR)NEt2]: Kinetic, Mechanistic and Preparative InvestigationsOn heating in solution, [(arylseleno)(diethylamino)carbene]pentacarbonylchromium complexes, (CO)5Cr[C(SeR)NEt2], (2) [R = 4-C6H4CF3 (a), 4-C6H4Br (b), 4-C6H4F (c), C6H5 (d), 4-C6H4CH3 (e), 4-C6H4OCH3 (f), 1-C10H7 (g)] rearrange with CO-elimination and C, Cr-migration of SeR to form the corresponding trans-(arylseleno)tetracarbonyl(diethylaminocarbyne) chromium complexes, trans-RSe(CO)4CrCNEt2, (3a-g). The rearrangement follows a first-order rate law. Free carbon monoxide does not influence the reaction rate whereas the Polarity of the solvent and the type of the substituent R only influence the rate of the reaction to a very small extent. The activation enthalpies are ΔH≠ = 101-104 kj mol-1, the activation entropies ΔS = 27-33 j mol-1 K-1. Addition of PPh3 to solutions of 2d does not influence the rate of the rearrangement but leads to a different reaction product, mer-(CO)3(PPh)3(SePh)CrCNEt2 (4d). Complex (4d). is also formed by photolysis of 2d in the presence of PPh3, The compounds 3a - d and 4d are characterized by analytical and spectroscopic means, 3c, additionally by an X-ray analysis.
    Notes: Beim Erwärmen in Lösung lagern sich die [(Arylseleno)(diethylamino)carben]pentacarbonyl-chrom-Komplexe, (CO)5Cr[C(SeR)NEt2], (2) [R = 4-C6H4CF3 (a), 4-C6H4Br (b), 4-C6H4 (c_, C6H4 (d), 4-C6H4OCH3 (e) 4-C6H4OCH3 (f), 1-C10H7 (g)] unter CO-Abspaltung und C, Cr-Wanderung von SeR zu den entsprechenden trans-(Arylseleno)tetracarbonyl(diethylaminocarbin)-chrom-Komplexen, trans-RSe(CO)4CrCNEt2, (3a-g) nach einem Geschwindigkeitsgesetz erster Ordnung um. Freies Kohlenmonoxid ist ohne, die Polarität des Solvens sowie die Art des Substituenten R sind nur von geringem Einfluß auf die Reaktionsgeschwindigkeit. Die Aktivierungsenthalpien betragen ΔH≠ = 101 104 kj mol-1, die Aktivierungsentropien ΔS≠ = 27-33 j mol-1 K-1. Zusatz von PPh3 zu Lösungen von 2d beeinflußt zwar die Umlagerungsgeschwindigkeit nicht, man erhält jedoch mer-(CO)3(PPh)3(SePh)CrCNEt2 (4d) als Reaktionsprodukt. Photolyse von 2d in THF in Anwesenheit von PPh3 liefert ebenfalls 4d. Die Verbindungen 3a-d und 4d wurden analytisch und spektroskopisch gesichert, 3c zusätzlich durch eine Röntgenstrukturanalyse.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19811141004
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  • 6
    Electronic Resource
    Electronic Resource
    Rubber toughening of polystyrene-acrylonitrile copolymers (1997)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 48 (1997), S. 553-561 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The efficiency of rubber toughening of PSAN depends on the size of the rubber particles, their agglomeration, the deformation rate, the temperature, and the orientation of the polymer molecules. Large particles are more effective than small particles. By a suitable choice of processing, however, small particles can agglomerate, forming large soft units and improving in this way impact toughness. At high deformation rates crazing or/and stretching of the matrix wall between the rubber particles must be activated for ductility, otherwise the material is brittle. The temperature at impact must be above the glass transition temperature of the rubbery phase for toughening. Increasing the orientation of the material decreases the tendency for craze formation with the consequence of embrittlement, if stretching is not activated.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1997.010481205
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  • 7
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    Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altare, F -- Durandy, A -- Lammas, D -- Emile, J F -- Lamhamedi, S -- Le Deist, F -- Drysdale, P -- Jouanguy, E -- Doffinger, R -- Bernaudin, F -- Jeppsson, O -- Gollob, J A -- Meinl, E -- Segal, A W -- Fischer, A -- Kumararatne, D -- Casanova, J L -- New York, N.Y. -- Science. 1998 May 29;280(5368):1432-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U429, Hopital Necker-Enfants Malades, Paris 75015, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9603732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytotoxicity, Immunologic ; Female ; Granuloma/immunology ; Humans ; Hypersensitivity, Delayed ; Interferon-gamma/biosynthesis/immunology/secretion ; Interleukin-12/*immunology ; Killer Cells, Natural/immunology ; Lymphocyte Activation ; Male ; Mice ; Mice, Knockout ; Mutation ; Mycobacterium avium-intracellulare Infection/*immunology ; *Mycobacterium bovis ; Pedigree ; Receptors, Interferon/genetics/immunology ; Receptors, Interleukin/deficiency/*genetics ; Receptors, Interleukin-12 ; T-Lymphocytes/immunology ; Tuberculosis/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    Localization of a short-term memory in Drosophila (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-04-28
    Description: Memories are thought to be due to lasting synaptic modifications in the brain. The search for memory traces has relied predominantly on determining regions that are necessary for the process. However, a more informative approach is to define the smallest sufficient set of brain structures. The rutabaga adenylyl cyclase, an enzyme that is ubiquitously expressed in the Drosophila brain and that mediates synaptic plasticity, is needed exclusively in the Kenyon cells of the mushroom bodies for a component of olfactory short-term memory. This demonstrates that synaptic plasticity in a small brain region can be sufficient for memory formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zars, T -- Fischer, M -- Schulz, R -- Heisenberg, M -- New York, N.Y. -- Science. 2000 Apr 28;288(5466):672-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Theodor Boveri Institut fur Biowissenschaften, Lehrstuhl fur Genetik, (Biozentrum) Am Hubland, D97074, Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10784450" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/genetics/*metabolism ; Animals ; Avoidance Learning ; Brain/enzymology/physiology ; Brain Mapping ; DNA-Binding Proteins ; Drosophila/enzymology/genetics/*physiology ; Electroshock ; Enhancer Elements, Genetic ; Fungal Proteins/genetics ; *Memory, Short-Term ; Mutation ; *Neuronal Plasticity ; Neurons/enzymology/*physiology ; Olfactory Pathways ; *Saccharomyces cerevisiae Proteins ; Smell ; Synapses/*physiology ; Transcription Factors/genetics ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-01-07
    Description: Dorsoventral patterning of vertebrate and Drosophila embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The Drosophila gene tolloid encodes a metalloprotease similar to BMP-1 that interacts genetically with decapentaplegic, the Drosophila homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blader, P -- Rastegar, S -- Fischer, N -- Strahle, U -- New York, N.Y. -- Science. 1997 Dec 12;278(5345):1937-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9395394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Patterning ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Protein Receptors ; Bone Morphogenetic Proteins/antagonists & inhibitors/*metabolism ; COS Cells ; Cell Lineage ; *Drosophila Proteins ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation, Developmental ; Glycoproteins/*metabolism ; Insect Proteins/genetics/*metabolism ; *Intercellular Signaling Peptides and Proteins ; RNA, Messenger/genetics/metabolism ; Receptors, Cell Surface/metabolism ; *Receptors, Growth Factor ; Signal Transduction ; Tolloid-Like Metalloproteinases ; Transfection ; Xenopus Proteins ; Zebrafish/*embryology/genetics/metabolism ; Zebrafish Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-12-02
    Description: MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in various disease states including cardiac disease. Whereas previous studies of cardiac disease have focused on microRNAs that are primarily expressed in cardiomyocytes, the role of microRNAs expressed in other cell types of the heart is unclear. Here we show that microRNA-21 (miR-21, also known as Mirn21) regulates the ERK-MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function. miR-21 levels are increased selectively in fibroblasts of the failing heart, augmenting ERK-MAP kinase activity through inhibition of sprouty homologue 1 (Spry1). This mechanism regulates fibroblast survival and growth factor secretion, apparently controlling the extent of interstitial fibrosis and cardiac hypertrophy. In vivo silencing of miR-21 by a specific antagomir in a mouse pressure-overload-induced disease model reduces cardiac ERK-MAP kinase activity, inhibits interstitial fibrosis and attenuates cardiac dysfunction. These findings reveal that microRNAs can contribute to myocardial disease by an effect in cardiac fibroblasts. Our results validate miR-21 as a disease target in heart failure and establish the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thum, Thomas -- Gross, Carina -- Fiedler, Jan -- Fischer, Thomas -- Kissler, Stephan -- Bussen, Markus -- Galuppo, Paolo -- Just, Steffen -- Rottbauer, Wolfgang -- Frantz, Stefan -- Castoldi, Mirco -- Soutschek, Jurgen -- Koteliansky, Victor -- Rosenwald, Andreas -- Basson, M Albert -- Licht, Jonathan D -- Pena, John T R -- Rouhanifard, Sara H -- Muckenthaler, Martina U -- Tuschl, Thomas -- Martin, Gail R -- Bauersachs, Johann -- Engelhardt, Stefan -- R01 CA059998/CA/NCI NIH HHS/ -- R01 CA78711/CA/NCI NIH HHS/ -- England -- Nature. 2008 Dec 18;456(7224):980-4. doi: 10.1038/nature07511. Epub 2008 Nov 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine I, Interdisziplinares Zentrum fur Klinische Forschung (IZKF), University of Wuerzburg, 97080 Wuerzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19043405" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cardiomyopathies/*genetics/*metabolism/pathology/therapy ; Cell Line ; Cell Survival ; Cells, Cultured ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibroblasts/*metabolism ; Gene Silencing ; Humans ; *MAP Kinase Signaling System ; Male ; Mice ; Mice, Transgenic ; MicroRNAs/*genetics ; Myocytes, Cardiac/cytology/metabolism ; Rats
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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