Publication Date:
1998-06-20
Description:
In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altare, F -- Durandy, A -- Lammas, D -- Emile, J F -- Lamhamedi, S -- Le Deist, F -- Drysdale, P -- Jouanguy, E -- Doffinger, R -- Bernaudin, F -- Jeppsson, O -- Gollob, J A -- Meinl, E -- Segal, A W -- Fischer, A -- Kumararatne, D -- Casanova, J L -- New York, N.Y. -- Science. 1998 May 29;280(5368):1432-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U429, Hopital Necker-Enfants Malades, Paris 75015, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9603732" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cytotoxicity, Immunologic
;
Female
;
Granuloma/immunology
;
Humans
;
Hypersensitivity, Delayed
;
Interferon-gamma/biosynthesis/immunology/secretion
;
Interleukin-12/*immunology
;
Killer Cells, Natural/immunology
;
Lymphocyte Activation
;
Male
;
Mice
;
Mice, Knockout
;
Mutation
;
Mycobacterium avium-intracellulare Infection/*immunology
;
*Mycobacterium bovis
;
Pedigree
;
Receptors, Interferon/genetics/immunology
;
Receptors, Interleukin/deficiency/*genetics
;
Receptors, Interleukin-12
;
T-Lymphocytes/immunology
;
Tuberculosis/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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