Publication Date:
1998-01-07
Description:
Dorsoventral patterning of vertebrate and Drosophila embryos requires bone morphogenetic proteins (BMPs) and antagonists of BMP activity. The Drosophila gene tolloid encodes a metalloprotease similar to BMP-1 that interacts genetically with decapentaplegic, the Drosophila homolog of vertebrate BMP-2/4. Zebrafish embryos overexpressing a zebrafish homolog of tolloid were shown to resemble loss-of-function mutations in chordino, the zebrafish homolog of the Xenopus BMP-4 antagonist Chordin. Furthermore, Chordin was degraded by COS cells expressing Tolloid. These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blader, P -- Rastegar, S -- Fischer, N -- Strahle, U -- New York, N.Y. -- Science. 1997 Dec 12;278(5345):1937-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C.U. de Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9395394" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
Bone Morphogenetic Protein 4
;
Bone Morphogenetic Protein Receptors
;
Bone Morphogenetic Proteins/antagonists & inhibitors/*metabolism
;
COS Cells
;
Cell Lineage
;
*Drosophila Proteins
;
Embryo, Nonmammalian/metabolism
;
Gene Expression Regulation, Developmental
;
Glycoproteins/*metabolism
;
Insect Proteins/genetics/*metabolism
;
*Intercellular Signaling Peptides and Proteins
;
RNA, Messenger/genetics/metabolism
;
Receptors, Cell Surface/metabolism
;
*Receptors, Growth Factor
;
Signal Transduction
;
Tolloid-Like Metalloproteinases
;
Transfection
;
Xenopus Proteins
;
Zebrafish/*embryology/genetics/metabolism
;
Zebrafish Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
