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  • Artikel  (496)
  • Pregnancy
  • American Association for the Advancement of Science (AAAS)  (496)
  • Blackwell Publishing Ltd
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  • Artikel  (496)
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  • 1
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    Stromal effects on mammary gland development and breast cancer (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-11
    Beschreibung: Breast cancer manifests itself in the mammary epithelium, yet there is a growing recognition that mammary stromal cells also play an important role in tumorigenesis. During its developmental cycle, the mammary gland displays many of the properties associated with breast cancer, and many of the stromal factors necessary for mammary development also promote or protect against breast cancer. Here we review our present knowledge of the specific factors and cell types that contribute to epithelial-stromal crosstalk during mammary development. To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788989/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788989/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wiseman, Bryony S -- Werb, Zena -- CA57621/CA/NCI NIH HHS/ -- R01 CA057621/CA/NCI NIH HHS/ -- R01 CA057621-07/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 May 10;296(5570):1046-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004111" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipocytes/cytology/physiology ; Animals ; Apoptosis ; Breast/cytology/embryology/*growth & development/physiology ; Breast Neoplasms/pathology/*physiopathology ; Cell Communication ; Epithelial Cells/physiology ; Extracellular Matrix/physiology ; Female ; Humans ; Mammary Glands, Animal/cytology/embryology/*growth & development/physiology ; Mammary Neoplasms, Animal/pathology/*physiopathology ; Morphogenesis ; Neoplasm Metastasis ; Pregnancy ; Signal Transduction ; Stromal Cells/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Historical essay. Prospects for the future (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallo, Robert C -- Montagnier, Luc -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1730-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459577" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Vaccines/immunology/therapeutic use ; *Acquired Immunodeficiency Syndrome/drug therapy/prevention & ; control/transmission/virology ; Anti-HIV Agents/therapeutic use ; Biomedical Research ; Clinical Trials as Topic ; Developed Countries ; Developing Countries ; Drug Costs ; Female ; HIV/drug effects ; Health Services/economics ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; International Cooperation ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Research Support as Topic ; Technology Transfer ; United Nations
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Bid for better beef gives Japan a leg up on cattle (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, D -- New York, N.Y. -- Science. 1998 Dec 11;282(5396):1975-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9874644" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Husbandry/*methods ; Animals ; Blastocyst ; Cattle/embryology/*genetics ; Cell Differentiation ; Cells, Cultured ; *Cloning, Organism ; Embryo Transfer/veterinary ; Fallopian Tubes/cytology ; Female ; Japan ; *Nuclear Transfer Techniques ; Oocytes ; Ovarian Follicle/cytology ; Pregnancy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Cocaine exposure and children: the meaning of subtle effects (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-12-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lester, B M -- LaGasse, L L -- Seifer, R -- U10 DA024119/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):633-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brown University School of Medicine, Providence, RI 02905-2499, USA. barryvlester@brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9841414" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Child Language ; Cocaine/*adverse effects ; Cocaine-Related Disorders/therapy ; Cognition Disorders/*chemically induced/prevention & control ; Costs and Cost Analysis ; Education, Special/economics ; Female ; Humans ; Intelligence/*drug effects ; Language Disorders/*chemically induced/prevention & control ; Meta-Analysis as Topic ; Pregnancy ; Pregnancy Complications/therapy ; *Prenatal Exposure Delayed Effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Intracytoplasmic sperm injection (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-10-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hawkins, M M -- Barratt, C L -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):51-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532889" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Congenital Abnormalities/etiology ; Developmental Disabilities/etiology ; Female ; Fertilization in Vitro/*adverse effects ; Great Britain ; Humans ; Male ; Neoplasms/etiology ; Pregnancy ; Pregnancy Outcome ; Registries ; Risk Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    HIV. French-led therapy fund kicks off in Africa (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-06-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, M -- New York, N.Y. -- Science. 1999 May 14;284(5417):1101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10366339" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/*therapeutic use ; Cote d'Ivoire ; Female ; *Financial Support ; France ; Fund Raising ; HIV Infections/*drug therapy/*prevention & control/transmission ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; *International Agencies/economics ; Pilot Projects ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Prospects for in utero human gene therapy (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-10-16
    Beschreibung: Gene therapy for the treatment of disease in children and adults is being actively pursued at many medical centers. However, a number of genetic disorders result in irreversible damage to the fetus before birth. In these cases, as well as for those with genetic diseases who may benefit from therapy before symptoms are manifested, in utero gene therapy (IUGT) could be beneficial. Although some successes with in utero gene transfer have been reported in animals, significant questions remain to be answered before IUGT clinical trials would be acceptable. This review analyzes the state of the art and delineates the studies that still need to be performed before it would be appropriate to consider human IUGT.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zanjani, E D -- Anderson, W F -- New York, N.Y. -- Science. 1999 Sep 24;285(5436):2084-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Veterans Administration Medical Center, University of Nevada, Reno, NV 89520, USA. zanjani@scs.unr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10523208" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Female ; Fetal Diseases/*therapy ; *Fetus ; Gene Transfer Techniques ; Genetic Diseases, Inborn/*therapy ; *Genetic Therapy/adverse effects ; Genetic Vectors ; Germ Cells ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology/physiology ; Humans ; Pregnancy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    South Africa's new enemy (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-15
    Beschreibung: Many South Africans long dreamed of the day when the oppressive apartheid system would end. That day has come, but now the country faces a new disaster: one of the world's worst HIV epidemics--and most confusing government responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2000 Jun 23;288(5474):2168-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10896606" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acquired Immunodeficiency Syndrome/epidemiology ; Anti-HIV Agents/therapeutic use ; Disease Outbreaks ; Female ; Government ; HIV Infections/drug therapy/epidemiology ; Humans ; Male ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Public Policy ; *Research ; South Africa/epidemiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Neurobiology. A new clue to how alcohol damages brains (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-02-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):947-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10691562" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Apoptosis ; Benzodiazepines/adverse effects/toxicity ; Brain/cytology/*drug effects/growth & development ; Ethanol/blood/*toxicity ; Female ; Humans ; Infant, Newborn ; Nerve Degeneration ; Neurons/cytology/*drug effects ; Pregnancy ; Rats ; Receptors, GABA/*drug effects/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*drug effects/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Pig cloning by microinjection of fetal fibroblast nuclei (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-08-19
    Beschreibung: Pig cloning will have a marked impact on the optimization of meat production and xenotransplantation. To clone pigs from differentiated cells, we microinjected the nuclei of porcine (Sus scrofa) fetal fibroblasts into enucleated oocytes, and development was induced by electroactivation. The transfer of 110 cloned embryos to four surrogate mothers produced an apparently normal female piglet. The clonal provenance of the piglet was indicated by her coat color and confirmed by DNA microsatellite analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onishi, A -- Iwamoto, M -- Akita, T -- Mikawa, S -- Takeda, K -- Awata, T -- Hanada, H -- Perry, A C -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1188-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Animal Breeding and Genetics, National Institute of Animal Industry, Tsukuba Norin Danchi, Ibaraki-ken 305-0901, Japan. onishi@niai.affrc.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947985" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Cloning, Organism/*methods ; Electric Stimulation ; Embryo Transfer ; Embryonic and Fetal Development ; Female ; Fetus/cytology ; Fibroblasts/ultrastructure ; Microinjections ; Microsatellite Repeats ; *Nuclear Transfer Techniques ; Oocytes ; Pregnancy ; *Swine/embryology/genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    South Africa in crisis on HIV/AIDS treatment (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-07-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, T T -- New York, N.Y. -- Science. 2001 Jun 29;292(5526):2431-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441877" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*drug therapy/prevention & ; control/transmission ; Anti-HIV Agents/*therapeutic use ; Drug Industry ; Female ; Health Policy ; Health Services Accessibility ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Nevirapine/therapeutic use ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; South Africa
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Transgenic monkeys produced by retroviral gene transfer into mature oocytes (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-02-24
    Beschreibung: Transgenic rhesus monkeys carrying the green fluorescent protein (GFP) gene were produced by injecting pseudotyped replication-defective retroviral vector into the perivitelline space of 224 mature rhesus oocytes, later fertilized by intracytoplasmic sperm injection. Of the three males born from 20 embryo transfers, one was transgenic when accessible tissues were assayed for transgene DNA and messenger RNA. All tissues that were studied from a fraternal set of twins, miscarried at 73 days, carried the transgene, as confirmed by Southern analyses, and the GFP transgene reporter was detected by both direct and indirect fluorescence imaging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, A W -- Chong, K Y -- Martinovich, C -- Simerly, C -- Schatten, G -- New York, N.Y. -- Science. 2001 Jan 12;291(5502):309-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oregon Regional Primate Research Center, Center for Women's Health, and Departments of Cell-Developmental Biology and Obstetrics-Gynecology, Oregon Health Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11209082" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Genetically Modified ; Animals, Newborn ; Blotting, Southern ; Embryo Transfer ; Embryonic and Fetal Development ; Female ; Fluorescent Antibody Technique ; Gene Expression ; *Gene Transfer Techniques ; *Gene Transfer, Horizontal ; Genetic Vectors ; Green Fluorescent Proteins ; Luminescent Proteins/*genetics ; Macaca mulatta/*genetics ; Male ; Moloney murine leukemia virus/genetics ; Oocytes ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Outcome ; Sperm Injections, Intracytoplasmic ; Transgenes
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Role of nonimmune IgG bound to PfEMP1 in placental malaria (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-09-15
    Beschreibung: Infections with Plasmodium falciparum during pregnancy lead to the accumulation of parasitized red blood cells (infected erythrocytes, IEs) in the placenta. IEs of P. falciparum isolates that infect the human placenta were found to bind immunoglobulin G (IgG). A strain of P. falciparum cloned for IgG binding adhered massively to placental syncytiotrophoblasts in a pattern similar to that of natural infections. Adherence was inhibited by IgG-binding proteins, but not by glycosaminoglycans or enzymatic digestion of chondroitin sulfate A or hyaluronic acid. Normal, nonimmune IgG that is bound to a duffy binding-like domain beta of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) might at the IE surface act as a bridge to neonatal Fc receptors of the placenta.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flick, K -- Scholander, C -- Chen, Q -- Fernandez, V -- Pouvelle, B -- Gysin, J -- Wahlgren, M -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2098-100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Microbiology and Tumor Biology Center (MTC), Karolinska Institutet and Swedish Institute for Infectious Disease Control, Box 280, S-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557894" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Adhesion ; Chondroitin ABC Lyase/metabolism ; Chondroitin Sulfates/metabolism/pharmacology ; Cloning, Molecular ; Erythrocytes/metabolism/*parasitology ; Female ; Humans ; Hyaluronic Acid/pharmacology ; Hyaluronoglucosaminidase/metabolism ; Immunoglobulin G/immunology/*metabolism ; Malaria, Falciparum/immunology/*parasitology ; Placenta/blood supply/immunology/*parasitology ; Placenta Diseases/immunology/parasitology ; Plasmodium falciparum/genetics/immunology/metabolism ; Pregnancy ; Pregnancy Complications, Parasitic/immunology/*parasitology ; Protein Structure, Tertiary ; Protozoan Proteins/chemistry/immunology/*metabolism ; Receptors, Fc/*metabolism ; Recombinant Fusion Proteins ; Staphylococcal Protein A/metabolism/pharmacology ; Trophoblasts/immunology/parasitology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Epigenetic instability in ES cells and cloned mice (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-07-07
    Beschreibung: Cloning by nuclear transfer (NT) is an inefficient process in which most clones die before birth and survivors often display growth abnormalities. In an effort to correlate gene expression with survival and fetal overgrowth, we have examined imprinted gene expression in both mice cloned by nuclear transfer and in the embryonic stem (ES) cell donor populations from which they were derived. The epigenetic state of the ES cell genome was found to be extremely unstable. Similarly, variation in imprinted gene expression was observed in most cloned mice, even in those derived from ES cells of the same subclone. Many of the animals survived to adulthood despite widespread gene dysregulation, indicating that mammalian development may be rather tolerant to epigenetic aberrations of the genome. These data imply that even apparently normal cloned animals may have subtle abnormalities in gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Humpherys, D -- Eggan, K -- Akutsu, H -- Hochedlinger, K -- Rideout , W M 3rd -- Biniszkiewicz, D -- Yanagimachi, R -- Jaenisch, R -- 5-R35-CA44339/CA/NCI NIH HHS/ -- R01-CA84198/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):95-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441181" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Birth Weight ; Cell Nucleus/*genetics ; Cesarean Section ; *Cloning, Organism/methods ; Congenital Abnormalities/genetics ; DNA Methylation ; Embryo Loss/genetics ; Embryo Transfer ; Embryo, Mammalian/*cytology/metabolism ; Female ; Fetal Death/genetics ; *Gene Expression Regulation, Developmental ; Gene Silencing ; Genomic Imprinting/*genetics ; Mice ; Oocytes/metabolism ; Placenta/metabolism ; Placentation ; Polyploidy ; Pregnancy ; RNA, Messenger/genetics/metabolism ; Respiration ; Stem Cells/*cytology/*metabolism ; Survival Rate
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    Quirks of fetal environment felt decades later (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-06-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2167-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077397" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Birth Weight ; Diabetes Mellitus, Type 2/epidemiology/etiology/physiopathology ; Diet ; *Disease Susceptibility ; Embryo Implantation ; Embryonic and Fetal Development ; Female ; Heart Diseases/epidemiology/etiology/physiopathology ; Humans ; Hydrocortisone/metabolism ; Hypertension/epidemiology/etiology/physiopathology ; *Infant, Low Birth Weight ; Infant, Newborn ; Placenta/physiology ; Pregnancy ; Pregnancy Complications/physiopathology ; *Prenatal Exposure Delayed Effects ; Risk Factors ; Stress, Physiological/physiopathology
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    Endocrinology. This hormone has been relaxin' too long! (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ivell, Richard -- New York, N.Y. -- Science. 2002 Jan 25;295(5555):637-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany. ivell@ihf.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11809958" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cyclic AMP/metabolism ; Endometrium/metabolism ; Endothelial Growth Factors/metabolism ; Female ; Humans ; Insulin ; Leydig Cells/metabolism ; Lymphokines/metabolism ; Male ; *Membrane Proteins ; Neovascularization, Physiologic ; Ovary/metabolism ; Pregnancy ; Proteins/chemistry/physiology ; Receptors, Cell Surface/chemistry/*physiology ; *Receptors, G-Protein-Coupled ; Receptors, Peptide/chemistry/*physiology ; Relaxin/blood/*physiology ; Reproduction ; Signal Transduction ; Testis/physiology ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Vasodilation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-11
    Beschreibung: Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors in meiotic chromosome segregation. Here, we show that the absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation. The abnormal oocyte karyotype is inherited by embryos, which die in utero at an early stage of development. In addition, embryo death in SCP3-deficient females increases with advancing maternal age. We found that SCP3 is required for chiasmata formation and for the structural integrity of meiotic chromosomes, suggesting that altered chromosomal structure triggers nondisjunction. SCP3 is thus linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yuan, Li -- Liu, Jian-Guo -- Hoja, Mary-Rose -- Wilbertz, Johannes -- Nordqvist, Katarina -- Hoog, Christer -- New York, N.Y. -- Science. 2002 May 10;296(5570):1115-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genomics and Bioinformatics and Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004129" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aneuploidy ; Animals ; Chromosome Segregation ; Chromosomes/*physiology/ultrastructure ; Crossing Over, Genetic ; *Embryo Loss ; Female ; Karyotyping ; Litter Size ; Male ; Maternal Age ; *Meiosis ; Mice ; Mice, Inbred C57BL ; Mutation ; Nondisjunction, Genetic ; Nuclear Proteins/genetics/*physiology ; Oocytes/*physiology ; Pregnancy ; Recombination, Genetic ; Synaptonemal Complex/physiology/ultrastructure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    A South African perspective on 2001 (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Timothy Trengove -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2015.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11898821" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/*therapeutic use ; Drug Industry/legislation & jurisprudence ; Female ; HIV Infections/*drug therapy/prevention & control/transmission ; Humans ; Infant ; Infectious Disease Transmission, Vertical/*prevention & control ; Jurisprudence ; Nevirapine/therapeutic use ; *Politics ; Pregnancy ; Preventive Health Services/*legislation & jurisprudence ; South Africa
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 19
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    Generation of live young from xenografted mouse ovaries (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-09-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Snow, Melanie -- Cox, Shae-Lee -- Jenkin, Graham -- Trounson, Alan -- Shaw, Jillian -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2227.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Monash University, Victoria, Australia, 3800.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12351780" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Embryo Loss ; Embryo Transfer ; Embryonic and Fetal Development ; Female ; Fertility ; Fertilization in Vitro ; Gonadotropins, Equine/administration & dosage ; Male ; Mice ; Mice, Inbred Strains ; Mice, Nude ; Oocytes/*physiology ; Ovariectomy ; Ovary/*transplantation ; Pregnancy ; Pregnancy Outcome ; Rats ; *Reproductive Techniques, Assisted ; *Transplantation, Heterologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    KDR receptor: a key marker defining hematopoietic stem cells (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-09-08
    Beschreibung: Studies on pluripotent hematopoietic stem cells (HSCs) have been hindered by lack of a positive marker, comparable to the CD34 marker of hematopoietic progenitor cells (HPCs). In human postnatal hematopoietic tissues, 0.1 to 0.5% of CD34(+) cells expressed vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR). Pluripotent HSCs were restricted to the CD34+KDR+ cell fraction. Conversely, lineage-committed HPCs were in the CD34+KDR- subset. On the basis of limiting dilution analysis, the HSC frequency in the CD34+KDR+ fraction was 20 percent in bone marrow (BM) by mouse xenograft assay and 25 to 42 percent in BM, peripheral blood, and cord blood by 12-week long-term culture (LTC) assay. The latter values rose to 53 to 63 percent in LTC supplemented with VEGF and to greater than 95 percent for the cell subfraction resistant to growth factor starvation. Thus, KDR is a positive functional marker defining stem cells and distinguishing them from progenitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ziegler, B L -- Valtieri, M -- Porada, G A -- De Maria, R -- Muller, R -- Masella, B -- Gabbianelli, M -- Casella, I -- Pelosi, E -- Bock, T -- Zanjani, E D -- Peschle, C -- New York, N.Y. -- Science. 1999 Sep 3;285(5433):1553-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Hematology and Oncology, University of Tubingen, Otfried-Muller-Strasse 10, D-72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10477517" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antigens, CD34/*analysis ; Bone Marrow Cells/cytology ; Cell Lineage ; Cell Separation ; Cells, Cultured ; Endothelial Growth Factors/pharmacology ; Female ; Fetal Blood/cytology ; Fetus ; Flow Cytometry ; *Hematopoiesis ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/chemistry/*cytology/drug effects/physiology ; Humans ; Lymphokines/pharmacology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Phenotype ; Pregnancy ; Receptor Protein-Tyrosine Kinases/*analysis/physiology ; Receptors, Growth Factor/*analysis/physiology ; Receptors, Vascular Endothelial Growth Factor ; Sheep ; Transplantation, Heterologous ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Cheap treatment cuts HIV transmission (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-03-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1999 Feb 12;283(5404):916-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10075556" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Anti-HIV Agents/*therapeutic use ; *Controlled Clinical Trials as Topic ; Drug Therapy, Combination ; Ethics, Medical ; Female ; HIV Infections/drug therapy/prevention & control/*transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Labor, Obstetric ; Lamivudine/therapeutic use ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Zidovudine/therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    A critical role for murine complement regulator crry in fetomaternal tolerance (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-01-22
    Beschreibung: Complement is a component of natural immunity. Its regulation is needed to protect tissues from inflammation, but mice with a disrupted gene for the complement regulator decay accelerating factor were normal. Mice that were deficient in another murine complement regulator, Crry, were generated to investigate its role in vivo. Survival of Crry-/- embryos was compromised because of complement deposition and concomitant placenta inflammation. Complement activation at the fetomaternal interface caused the fetal loss because breeding to C3-/- mice rescued Crry-/- mice from lethality. Thus, the regulation of complement is critical in fetal control of maternal processes that mediate tissue damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, C -- Mao, D -- Holers, V M -- Palanca, B -- Cheng, A M -- Molina, H -- R01 AI40576-01/AI/NIAID NIH HHS/ -- R01 AI44912-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):498-501.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10642554" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Complement Activation ; Complement C3/analysis/immunology ; Embryo, Mammalian/*immunology/metabolism ; *Embryonic and Fetal Development ; Female ; Gene Targeting ; *Immune Tolerance ; Mice ; Neutrophil Infiltration ; Pregnancy ; Receptors, Complement/genetics/*physiology ; Trophoblasts/immunology/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-07
    Beschreibung: Hypertension and pregnancy-related hypertension are major public health problems of largely unknown causes. We describe a mutation in the mineralocorticoid receptor (MR), S810L, that causes early-onset hypertension that is markedly exacerbated in pregnancy. This mutation results in constitutive MR activity and alters receptor specificity, with progesterone and other steroids lacking 21-hydroxyl groups, normally MR antagonists, becoming potent agonists. Structural and biochemical studies indicate that the mutation results in the gain of a van der Waals interaction between helix 5 and helix 3 that substitutes for interaction of the steroid 21-hydroxyl group with helix 3 in the wild-type receptor. This helix 5-helix 3 interaction is highly conserved among diverse nuclear hormone receptors, suggesting its general role in receptor activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geller, D S -- Farhi, A -- Pinkerton, N -- Fradley, M -- Moritz, M -- Spitzer, A -- Meinke, G -- Tsai, F T -- Sigler, P B -- Lifton, R P -- New York, N.Y. -- Science. 2000 Jul 7;289(5476):119-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, Room 154, 295 Congress Avenue, New Haven, CT 06510, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10884226" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Aldosterone/*metabolism ; Amino Acid Sequence ; Amino Acid Substitution ; Base Sequence ; Binding, Competitive ; Dimerization ; Female ; Heterozygote ; Humans ; Hypertension/etiology/*genetics/metabolism ; Male ; Models, Molecular ; Molecular Sequence Data ; Pedigree ; Point Mutation ; Pregnancy ; *Pregnancy Complications, Cardiovascular/etiology/metabolism ; Progesterone/*metabolism ; Protein Conformation ; Protein Structure, Secondary ; Receptors, Mineralocorticoid/chemistry/*genetics/*metabolism ; Receptors, Steroid/chemistry/metabolism ; Steroids/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    Profile: McIntyre and Gray have a will and a way (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-15
    Beschreibung: At the Chris Hani Baragwanath Hospital here, where HIV infects more than 20% of the 17,000 pregnant women who give birth here each year, pediatrician Glenda Gray and obstetrician James McIntyre aggressively try to help HIV-infected pregnant women stop the virus from infecting their babies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2000 Jun 23;288(5474):2163.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10896602" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/diagnosis/drug therapy/prevention & control/*transmission ; History, 20th Century ; Humans ; *Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis/*drug therapy ; South Africa
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 25
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    Embryos attacked by mom's natural defenses (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-02-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hagmann, M -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):408.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10671158" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Complement Activation ; Complement System Proteins/*immunology ; Embryo, Mammalian/*immunology ; Female ; Humans ; *Immune Tolerance ; Immunity, Innate ; Mice ; Mice, Knockout ; Pregnancy ; Receptors, Complement/genetics/*physiology ; Trophoblasts/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 26
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    Zoo biology. A fertile mind on wildlife conservation's front lines (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-11-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1271-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11701910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Zoo/anatomy & histology/physiology ; Conservation of Natural Resources ; Cryopreservation ; *Elephants/anatomy & histology/physiology ; Female ; Genitalia, Female/*ultrasonography ; Insemination, Artificial/*veterinary ; Male ; Pregnancy ; Semen Preservation ; Ultrasonography/*veterinary
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 27
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    Mother-to-child HIV transmission and ARVs (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Vlas, Sake J -- Nagelkerke, Nico J D -- Jha, Prabhat -- Plummer, Frank A -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481779" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/economics/*therapeutic use ; Child ; Developing Countries ; Drug Costs ; Drug Resistance, Viral ; Female ; HIV/drug effects/physiology ; HIV Infections/drug therapy/prevention & control/*transmission/virology ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Viral Load
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 28
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    A gender gap in autoimmunity (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-03-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Whitacre, C C -- Reingold, S C -- O'Looney, P A -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1277-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Microbiology and Immunology, Ohio State University, Columbus, OH 43210, USA. whitacre.3@osu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10084932" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibody Formation ; *Autoimmune Diseases/genetics/immunology/therapy ; *Autoimmunity ; Cytokines/biosynthesis/immunology ; Female ; Genetic Predisposition to Disease ; Gonadal Steroid Hormones/physiology ; Hormones/physiology ; Humans ; Immunity, Cellular ; Male ; Pregnancy ; Pregnancy Complications/immunology ; *Sex Characteristics ; Th1 Cells/immunology ; Th2 Cells/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 29
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    How embryos may avoid immune attack (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-09-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1998 Aug 21;281(5380):1122-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9735025" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Embryo, Mammalian/*immunology ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; *Immune Tolerance ; Male ; Mice ; Placenta/enzymology ; Pregnancy ; T-Lymphocytes/*immunology/metabolism ; Trophoblasts/*enzymology ; Tryptophan/analogs & derivatives/*metabolism/pharmacology ; Tryptophan Oxygenase/antagonists & inhibitors/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 30
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    Animal cloning. Clones: a hard act to follow (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-06
    Beschreibung: Often left out of news reports of cloned animals is the fact that for every 100 attempts, just two or three live offspring typically result. Now many researchers are going back to the lab to attempt to find out why. They are probing fundamental questions of cell biology, as well as trying to figure out whether there is something inherently flawed in "asexual" reproduction in mammals, or whether some problem lies in the in vitro component of the process. For now, the serious obstacles suggest that human cloning may be a long way off.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- Vogel, G -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1722-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877684" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Domestic/embryology/genetics ; Animals, Genetically Modified ; Bioethics ; Cell Differentiation ; Cell Division ; *Cloning, Organism/adverse effects/economics/methods ; Embryo Transfer ; Embryo, Mammalian/cytology ; Female ; Gene Targeting ; Gene Transfer Techniques ; Humans ; Mice/embryology/genetics ; Nuclear Transfer Techniques ; Pregnancy ; Primates/embryology/genetics
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Biotechnology. Perseverance leads to cloned pig in Japan (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-09-02
    Beschreibung: Low success rates and unpredictable results have plagued cloning researchers, particularly those trying to clone pigs. Now, on page 1188, Japanese researchers offer the first scientific report of a cloned pig, named Xena, raising hopes that pigs could one day provide an unlimited supply of organs for transplantation thanks to their close physiological relationship to humans. But this week those hopes were dealt a blow by more evidence suggesting that pig retroviruses can infect human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- Normile, D -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1118-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10970216" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cloning, Organism/*methods ; Embryo Transfer ; Female ; Fibroblasts/ultrastructure ; Japan ; Microinjections ; Nuclear Transfer Techniques ; Pregnancy ; *Swine/embryology/genetics ; Transplantation, Heterologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 32
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    Hypertension. Mutation points to salt recycling pathway (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-08-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wickelgren, I -- New York, N.Y. -- Science. 2000 Jul 7;289(5476):23-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10928921" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aldosterone/metabolism ; Female ; Humans ; Hypertension/etiology/*genetics/metabolism ; Kidney/metabolism ; Male ; *Point Mutation ; Pregnancy ; Pregnancy Complications, Cardiovascular/etiology/metabolism ; Progesterone/*metabolism ; Protein Structure, Secondary ; Receptors, Mineralocorticoid/chemistry/*genetics/*metabolism ; Sodium Chloride/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-02-11
    Beschreibung: The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABA(A) receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain. Vulnerability coincides with the period of synaptogenesis, which in humans extends from the sixth month of gestation to several years after birth. During this period, transient ethanol exposure can delete millions of neurons from the developing brain. This can explain the reduced brain mass and neurobehavioral disturbances associated with human fetal alcohol syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ikonomidou, C -- Bittigau, P -- Ishimaru, M J -- Wozniak, D F -- Koch, C -- Genz, K -- Price, M T -- Stefovska, V -- Horster, F -- Tenkova, T -- Dikranian, K -- Olney, J W -- AG 11355/AG/NIA NIH HHS/ -- DA 05072/DA/NIDA NIH HHS/ -- MH 38894/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):1056-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatric Neurology, Charite, Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10669420" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Apoptosis ; Benzodiazepines/pharmacology ; Dose-Response Relationship, Drug ; Ethanol/administration & dosage/blood/*toxicity ; Female ; Fetal Alcohol Spectrum Disorders/*pathology ; GABA Modulators/pharmacology ; Humans ; *Nerve Degeneration ; Neurons/cytology/pathology ; Organ Size/drug effects ; Pregnancy ; Prosencephalon/cytology/*drug effects/embryology/growth & development ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A/*drug effects/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/*drug effects/metabolism ; Synapses/drug effects/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    Clonal propagation of primate offspring by embryo splitting (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-01-15
    Beschreibung: Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. A total of 368 multiples were created by the splitting of 107 rhesus embryos with four pregnancies established after 13 embryo transfers (31% versus 53% in vitro fertilization controls). The birth of Tetra, a healthy female cloned from a quarter of an embryo, proves that this approach can result in live offspring.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, A W -- Dominko, T -- Luetjens, C M -- Neuber, E -- Martinovich, C -- Hewitson, L -- Simerly, C R -- Schatten, G P -- New York, N.Y. -- Science. 2000 Jan 14;287(5451):317-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oregon Regional Primate Research Center, Beaverton, OR 97006, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10634789" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Apoptosis ; Blastocyst/physiology ; Blastomeres/*physiology ; Cleavage Stage, Ovum/*physiology ; Cloning, Organism/*methods ; Embryo Transfer ; *Embryonic and Fetal Development ; Female ; Macaca mulatta/*embryology ; Pregnancy ; Twins, Monozygotic ; Zona Pellucida/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Childhood cancer (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-02-12
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, J A -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):427.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10671164" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Child ; Data Collection ; Environmental Exposure/adverse effects ; Female ; Genetic Predisposition to Disease ; Humans ; Interviews as Topic ; Leukemia/etiology/genetics ; Neoplasms/*etiology/genetics ; Pregnancy ; Prenatal Exposure Delayed Effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    The mother of all HIV challenges (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-15
    Beschreibung: AIDS researchers are finding cheaper and simpler ways to slow the spread of HIV from mother to child, and more pregnant women, even in the poorest countries, have access to anti-HIV drugs and formula--thanks to the largesse of donors, discounts from industry, new trade laws, and the tenacity of individual clinicians. But just as researchers offer ways to clear one enormous hurdle--drug availability--they run smack into other ones, ranging from social stigmas that discourage testing to disinterest on the part of cash-strapped health authorities to a deeply ingrained culture of breast-feeding--often supported by government policy for otherwise sound health reasons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 2000 Jun 23;288(5474):2160-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10896599" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): AIDS Serodiagnosis ; Africa South of the Sahara ; Anti-HIV Agents/*therapeutic use ; Breast Feeding/*adverse effects ; Clinical Trials as Topic ; Female ; HIV Infections/drug therapy/*prevention & control/*transmission ; Humans ; Infant, Newborn ; *Infectious Disease Transmission, Vertical ; Nevirapine/therapeutic use ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Social Conditions ; Zidovudine/therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Biomedicine. Turncoat antibodies (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-09-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duffy, P E -- Fried, M -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2009-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Seattle Biomedical Research Institute, Seattle, WA 98109, USA. pduffy@sbri.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557864" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Protozoan/immunology ; Cell Adhesion ; Chondroitin Sulfates/metabolism ; Erythrocytes/metabolism/*parasitology ; Female ; Humans ; Hyaluronic Acid/metabolism ; Immunoglobulin G/immunology/*metabolism ; Malaria Vaccines ; Malaria, Falciparum/immunology/*parasitology/prevention & control ; Placenta/metabolism/parasitology ; Placenta Diseases/immunology/parasitology ; Plasmodium falciparum/immunology ; Pregnancy ; Pregnancy Complications, Parasitic/immunology/*parasitology/prevention & control ; Protein Structure, Tertiary ; Protozoan Proteins/chemistry/immunology/*metabolism ; Receptors, Fc/*metabolism ; Trophoblasts/immunology/metabolism/parasitology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Transgenic animals. Infant monkey carries jellyfish gene (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-03-17
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, G -- New York, N.Y. -- Science. 2001 Jan 12;291(5502):226.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11253205" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Animals, Genetically Modified ; Embryo Transfer ; Female ; Gene Expression ; Gene Transfer Techniques ; Gene Transfer, Horizontal ; Green Fluorescent Proteins ; Luminescent Proteins/*genetics ; Macaca mulatta/*genetics ; Male ; Pregnancy ; Sperm Injections, Intracytoplasmic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 39
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    Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-05
    Beschreibung: The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lai, Liangxue -- Kolber-Simonds, Donna -- Park, Kwang-Wook -- Cheong, Hee-Tae -- Greenstein, Julia L -- Im, Gi-Sun -- Samuel, Melissa -- Bonk, Aaron -- Rieke, August -- Day, Billy N -- Murphy, Clifton N -- Carter, David B -- Hawley, Robert J -- Prather, Randall S -- R44 RR15198/RR/NCRR NIH HHS/ -- T32 RR07004/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1089-92. Epub 2002 Jan 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Animal Science, University of Missouri, Columbia, MO 65211, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778012" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Animals ; *Animals, Genetically Modified ; Cell Line ; *Cloning, Organism ; Embryo Transfer ; Female ; Fetus ; Fibroblasts ; Galactosyltransferases/*genetics ; *Gene Targeting ; Genetic Vectors ; Male ; Mutagenesis, Insertional ; Nuclear Transfer Techniques ; Pregnancy ; Recombination, Genetic ; Swine ; Swine, Miniature/embryology/*genetics ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 40
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    Improving the health of the global poor (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-16
    Beschreibung: We analyzed the technical basis for a major global program to reduce disease among the poor. Effective interventions exist against the few diseases which most account for excess mortality among the poor. Achieving high coverage of effective interventions requires a well-functioning health system, as well as overcoming a set of financial and nonfinancial constraints. The annual incremental cost would be between $40 billion and $52 billion by 2015 in 83 low-income and sub-Saharan African countries. Such a program is feasible and would avoid millions of child, maternal, and adult deaths annually in poor countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jha, Prabhat -- Mills, Anne -- Hanson, Kara -- Kumaranayake, Lilani -- Conteh, Lesong -- Kurowski, Christoph -- Nguyen, Son Nam -- Cruz, Valeria Oliveira -- Ranson, Kent -- Vaz, Lara M E -- Yu, Shengchao -- Morton, Oliver -- Sachs, Jeffrey D -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2036-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉World Health Organization (WHO), Geneva 01220, Switzerland. jhap@who.int〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896266" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Child ; *Delivery of Health Care/economics ; Female ; *Global Health ; Government ; Health Care Costs ; *Health Expenditures ; Health Services Accessibility ; *Health Status ; Humans ; Immunization Programs/economics ; *Medically Underserved Area ; *Poverty ; Pregnancy ; Preventive Health Services/economics ; Public Policy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 41
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    Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-04-16
    Beschreibung: The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants were viable and fertile, target organs such as uterus, prostate, testis, and mammary gland exhibited decreased growth and development in response to steroid hormones. Expression of RNA encoding TIF2, a member of the SRC-1 family, was increased in the SRC-1 null mutant, perhaps compensating partially for the loss of SRC-1 function in target tissues. The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, J -- Qiu, Y -- DeMayo, F J -- Tsai, S Y -- Tsai, M J -- O'Malley, B W -- New York, N.Y. -- Science. 1998 Mar 20;279(5358):1922-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9506940" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Drug Resistance ; Estradiol/blood/pharmacology ; Female ; Gene Targeting ; Genitalia, Male/drug effects/*growth & development ; Gonadal Steroid Hormones/*pharmacology ; Histone Acetyltransferases ; Male ; Mammary Glands, Animal/drug effects/*growth & development ; Mice ; Nuclear Receptor Coactivator 1 ; Nuclear Receptor Coactivator 2 ; Organ Size/drug effects ; Pregnancy ; Progesterone/blood/pharmacology ; Prostate/drug effects/growth & development ; Stem Cells ; Testis/drug effects/growth & development ; Testosterone/blood/pharmacology ; Transcription Factors/genetics/*physiology ; Uterus/drug effects/*growth & development
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 42
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    Solving the brain's energy crisis (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-06-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, A -- New York, N.Y. -- Science. 1998 May 29;280(5368):1345-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9634409" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Evolution ; Brain/*anatomy & histology/growth & development/metabolism ; Digestive System/*anatomy & histology/metabolism ; *Energy Metabolism ; Female ; Genomic Imprinting ; Humans ; Lactation ; Male ; Maternal-Fetal Exchange ; Mice ; Placenta/metabolism ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 43
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    Policy forum: human genetics. Ethical considerations in leaping from bench to bedside (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-10-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sugarman, J -- New York, N.Y. -- Science. 1999 Sep 24;285(5436):2071-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. sugar001@mc.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10523204" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Deaminase/deficiency ; Animals ; Clinical Trials as Topic/*standards ; *Ethics, Medical ; Female ; Fetal Diseases/*therapy ; Gene Transfer Techniques ; *Genetic Therapy/adverse effects ; *Human Experimentation ; Humans ; Informed Consent ; Nontherapeutic Human Experimentation ; Pregnancy ; Pregnant Women ; Research Design ; Safety ; Severe Combined Immunodeficiency/therapy ; alpha-Thalassemia/therapy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 44
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    Profits from precious pets (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-07-06
    Beschreibung: In 1998, an anonymous millionaire, hoping to clone his pet dog Missy, awarded a Texas A&M University animal scientist $2.3 million to develop the necessary techniques. Now several companies are cashing in on the boom in frozen-tissue storage of pets for future cloning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1726.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877685" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cats/embryology/genetics ; Cloning, Organism/*economics/methods ; Costs and Cost Analysis ; *Dogs/embryology/genetics ; Female ; Pregnancy ; Tissue Preservation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2000-09-16
    Beschreibung: In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. The SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of SK3 expression while retaining normal SK3 promoter function. An absence of SK3 did not present overt phenotypic consequences. However, SK3 overexpression induced abnormal respiratory responses to hypoxia and compromised parturition. Both conditions were corrected by silencing the gene. The results implicate SK3 channels as potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bond, C T -- Sprengel, R -- Bissonnette, J M -- Kaufmann, W A -- Pribnow, D -- Neelands, T -- Storck, T -- Baetscher, M -- Jerecic, J -- Maylie, J -- Knaus, H G -- Seeburg, P H -- Adelman, J P -- New York, N.Y. -- Science. 2000 Sep 15;289(5486):1942-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vollum Institute, Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, OR 97201, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10988076" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 5' Untranslated Regions ; Action Potentials ; Animals ; Anoxia/metabolism ; Brain/metabolism ; Crosses, Genetic ; Culture Techniques ; Doxycycline/pharmacology ; Female ; Gene Expression ; Gene Expression Regulation/drug effects ; Gene Targeting ; Labor, Obstetric/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Potassium Channels/genetics/*physiology ; *Potassium Channels, Calcium-Activated ; Pregnancy ; *Respiratory Physiological Phenomena ; Small-Conductance Calcium-Activated Potassium Channels
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Glycoprotein structure determination by mass spectrometry (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-03-28
    Beschreibung: The human genome encodes 30,000 to 40,000 proteins, and a major challenge is to understand how posttranslational events, such as glycosylation, affect the activities and functions of these proteins in health and disease. Glycosylated proteins are ubiquitous components of extracellular matrices and cellular surfaces where their oligosaccharide moieties are implicated in a wide range of cell-cell and cell-matrix recognition events. The power of ultrahigh-sensitivity mass spectrometric strategies for defining the primary structures of highly complex mixtures of glycoprotein glycoforms is set to revolutionize structural glycobiology in the coming postgenomic era.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dell, A -- Morris, H R -- New York, N.Y. -- Science. 2001 Mar 23;291(5512):2351-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK. a.dell@ic.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11269315" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbohydrate Metabolism, Inborn Errors/metabolism ; Female ; Glycoproteins/*chemistry/metabolism ; Glycosylation ; Humans ; *Mass Spectrometry/methods ; Mucins/chemistry ; Pregnancy ; Pregnancy Proteins/chemistry/metabolism ; Prions/chemistry/metabolism ; Protein Processing, Post-Translational ; Spectrometry, Mass, Electrospray Ionization ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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    Human cloning. Experts assail plan to help childless couples (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-03-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickrell, J -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2061-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11256389" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cloning, Organism/adverse effects ; Female ; Humans ; Internationality ; Male ; Oligospermia ; Pregnancy ; Pregnancy Complications ; Surrogate Mothers
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 48
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    Infectious diseases. Bed nets prove their mettle against malaria (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2001-12-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Enserink, M -- New York, N.Y. -- Science. 2001 Dec 14;294(5550):2271.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11743176" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Bedding and Linens ; Child ; Female ; Humans ; Infant ; *Insecticides ; Kenya ; Malaria/*prevention & control/*transmission ; Mosquito Control ; *Permethrin ; Placenta Diseases/parasitology/prevention & control ; Pregnancy ; Pregnancy Complications, Parasitic/prevention & control ; Randomized Controlled Trials as Topic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Xenotransplantation. Cloned pigs may help overcome rejection (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-01-05
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2002 Jan 4;295(5552):25-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11778016" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Genetically Modified ; *Cloning, Organism ; Embryo Transfer ; Female ; Galactosyltransferases/*genetics/immunology ; Genetic Vectors ; Graft Rejection/*prevention & control ; Humans ; Pregnancy ; Swine/*genetics ; *Transplantation, Heterologous
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 50
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    Ethics of AZT studies in poorer countries attacked (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-05-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, J -- New York, N.Y. -- Science. 1997 May 16;276(5315):1022.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9173534" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa ; Anti-HIV Agents/administration & dosage/*therapeutic use ; *Bioethics ; Caribbean Region ; *Control Groups ; Controlled Clinical Trials as Topic/*standards ; Female ; HIV Infections/drug therapy/prevention & control/*transmission ; Humans ; Infectious Disease Transmission, Vertical/*prevention & control ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; *Pregnant Women ; Thailand ; Therapeutic Human Experimentation ; Withholding Treatment ; Zidovudine/administration & dosage/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 51
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    Group brands AIDS trials unethical (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-04-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1997 Apr 25;276(5312):519.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148403" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*drug therapy/transmission ; Anti-HIV Agents/*therapeutic use ; *Controlled Clinical Trials as Topic/standards ; *Developing Countries ; *Ethics, Medical ; Female ; Humans ; Infant ; Infant, Newborn ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Zidovudine/therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Study shows one-fifth of female bison infected (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-06-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baskin, Y -- New York, N.Y. -- Science. 1997 Jun 20;276(5320):1786.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9206836" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Veterinary/microbiology ; Animals ; *Bison ; *Brucella abortus ; Brucellosis/*epidemiology/transmission ; Brucellosis, Bovine/*transmission ; Cattle ; Female ; Montana/epidemiology ; Pregnancy ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 53
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    AIDS: an international perspective (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1988-02-05
    Beschreibung: The acquired immunodeficiency syndrome (AIDS) and infection with the human immunodeficiency virus type 1 (HIV-1) constitute a worldwide public health problem. Whereas in Europe and in most of the Americas transmission of HIV-1 has occurred predominantly among homosexual men and intravenous drug abusers, in Africa a distinct epidemiologic pattern has emerged that indicates that HIV-1 infection is mainly heterosexually acquired. Heterosexual transmission appears to be increasing in some parts of Latin America and the Caribbean, and possibly in the United States. In addition to HIV-1, at least one other human retrovirus, namely HIV-2, has been implicated as a cause of AIDS in Africa and Europe. Factors that influence heterosexual transmission of HIV-1 include genital ulcerations, early or late stages of HIV-1 infection in the index case, and possibly oral contraception and immune activation. The rate of perinatal transmission is enhanced when the mother's illness is more advanced. AIDS and HIV-1 infection may have a significant impact not only on public health, but also on the demography and socioeconomic conditions of some developing countries. Programs for the prevention and control of AIDS should be an immediate priority in all countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piot, P -- Plummer, F A -- Mhalu, F S -- Lamboray, J L -- Chin, J -- Mann, J M -- New York, N.Y. -- Science. 1988 Feb 5;239(4840):573-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3277271" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/epidemiology/prevention & ; control/*transmission ; Female ; HIV/classification/pathogenicity ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Sexual Behavior
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 54
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    Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1988-07-15
    Beschreibung: In 1979, a mass poisoning occurred in Taiwan from cooking oil contaminated by thermally degraded polychlorinated biphenyls. Because these chemicals persist in human tissue, children born to female patients after the outbreak were exposed in utero. In 1985, 117 children born to affected women and 108 unexposed controls were examined and evaluated. The exposed children were shorter and lighter than controls; they had abnormalities of gingiva, skin, nails, teeth, and lungs more frequently than did controls. The exposed children showed delay of developmental milestones, deficits on formal developmental testing, and abnormalities on behavioral assessment. These findings are most consistent with a generalized disorder of ectodermal tissue. This syndrome is one of very few documented to result from transplacental exposure to pollutant chemicals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rogan, W J -- Gladen, B C -- Hung, K L -- Koong, S L -- Shih, L Y -- Taylor, J S -- Wu, Y C -- Yang, D -- Ragan, N B -- Hsu, C C -- New York, N.Y. -- Science. 1988 Jul 15;241(4863):334-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3133768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Conjunctivitis/chemically induced/congenital ; Female ; Growth Disorders/chemically induced ; Humans ; Lactation ; Maternal-Fetal Exchange ; Nails, Malformed ; Oils/*adverse effects ; Pigmentation Disorders/chemically induced/congenital ; Polychlorinated Biphenyls/*poisoning ; Pregnancy ; Taiwan
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 55
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    Molecular cloning of two types of GAP complementary DNA from human placenta (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1988-12-23
    Beschreibung: The ras p21 GTPase-activating protein (GAP) was purified from human placental tissue. Internal amino acid sequence was obtained from this 120,000-dalton protein and, by means of this sequence, two types of complementary DNA clones were isolated and characterized. One type encoded GAP with a predicted molecular mass of 116,000 daltons and 96% identity with bovine GAP. The messenger RNA of this GAP was detected in human lung, brain, liver, leukocytes, and placenta. The second type appeared to be generated by a differential splicing mechanism and encoded a novel form of GAP with a predicted molecular mass of 100,400 daltons. This protein lacks the hydrophobic amino terminus characteristic of the larger species, but retains GAP activity. The messenger RNA of this type was abundantly expressed in placenta and in several human cell lines, but not in adult tissues.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trahey, M -- Wong, G -- Halenbeck, R -- Rubinfeld, B -- Martin, G A -- Ladner, M -- Long, C M -- Crosier, W J -- Watt, K -- Koths, K -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1697-700.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Cetus Corp., Emeryville, CA 94608.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3201259" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Base Sequence ; Brain Chemistry ; *Cloning, Molecular ; DNA/*genetics/isolation & purification ; Female ; GTPase-Activating Proteins ; Gene Expression Regulation ; Humans ; Leukocytes/analysis ; Liver/analysis ; Lung/analysis ; Molecular Sequence Data ; Molecular Weight ; Nucleic Acid Hybridization ; Oligonucleotide Probes ; Placenta/*analysis ; Pregnancy ; Proteins/*genetics/isolation & purification ; RNA, Messenger/analysis/genetics ; Sequence Homology, Nucleic Acid ; ras GTPase-Activating Proteins
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 56
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    Fetal research (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1989-11-10
    Beschreibung: This article reviews some of the significant contributions of fetal research and fetal tissue research over the past 20 years. The benefits of fetal research include the development of vaccines, advances in prenatal diagnosis, detection of malformations, assessment of safe and effective medications, and the development of in utero surgical therapies. Fetal tissue research benefits vaccine development, assessment of risk factors and toxicity levels in drug production, development of cell lines, and provides a source of fetal cells for ongoing transplantation trials. Together, fetal research and fetal tissue research offer tremendous potential for the treatment of the fetus, neonate, and adult.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hansen, J T -- Sladek, J R Jr -- P01-NS24032/NS/NINDS NIH HHS/ -- P01-NS25778/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1989 Nov 10;246(4931):775-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY 14642.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2683082" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Congenital Abnormalities/diagnosis ; Female ; *Fetal Diseases ; *Fetal Research ; *Fetus/cytology/surgery ; Genetic Diseases, Inborn ; Humans ; Nontherapeutic Human Experimentation ; Pregnancy ; Prenatal Diagnosis ; *Research ; *Risk Assessment ; Therapeutic Human Experimentation ; Vaccines
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    The choosing of the NIH director (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1989-11-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1989 Nov 24;246(4933):981.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2587989" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Legal ; Female ; Humans ; National Institutes of Health (U.S.)/*organization & administration ; Politics ; Pregnancy ; United States ; United States Dept. of Health and Human Services
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 58
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    Toward safe and effective medical abortion (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-08-15
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ewart, W R -- Winikoff, B -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1998 Jul 24;281(5376):520-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Wellcome Trust, London, UK. population@wellcome.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9705721" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortifacient Agents/supply & distribution ; *Abortion, Induced ; Biomedical Research ; Delivery of Health Care ; Developing Countries ; Female ; Humans ; *Internationality ; Legislation, Drug ; Methotrexate ; *Mifepristone/supply & distribution ; Misoprostol ; Pregnancy ; Risk Assessment ; Therapeutic Human Experimentation ; Women's Health
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 59
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    Methylmercury risks (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-02-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weihe, P -- Grandjean, P -- New York, N.Y. -- Science. 1998 Jan 30;279(5351):639; author reply 641.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9471722" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Child ; Cognition/drug effects ; Female ; *Food Contamination ; Humans ; Methylmercury Compounds/*adverse effects ; Nervous System/drug effects ; Nutrition Policy ; Pregnancy ; *Prenatal Exposure Delayed Effects ; *Seafood ; United States ; United States Environmental Protection Agency
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 60
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    Eight calves cloned from somatic cells of a single adult (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-12-16
    Beschreibung: Eight calves were derived from differentiated cells of a single adult cow, five from cumulus cells and three from oviductal cells out of 10 embryos transferred to surrogate cows (80 percent success). All calves were visibly normal, but four died at or soon after birth from environmental causes, and postmortem analysis revealed no abnormality. These results show that bovine cumulus and oviductal epithelial cells of the adult have the genetic content to direct the development of newborn calves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kato, Y -- Tani, T -- Sotomaru, Y -- Kurokawa, K -- Kato, J -- Doguchi, H -- Yasue, H -- Tsunoda, Y -- New York, N.Y. -- Science. 1998 Dec 11;282(5396):2095-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Animal Reproduction, College of Agriculture and Research Institute for Animal Developmental Biotechnology, Kinki University, 3327-204, Nakamachi, Nara, 631-8505, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9851933" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Husbandry ; Animals ; Blastocyst/cytology ; Cattle/embryology/*genetics ; Cell Fusion ; Cells, Cultured ; Cloning, Organism/*methods ; Cytoplasm/physiology ; Embryo Transfer/veterinary ; Epithelial Cells/cytology ; Fallopian Tubes/*cytology ; Female ; Microsatellite Repeats ; *Nuclear Transfer Techniques ; Oocytes/*cytology ; Ovarian Follicle/*cytology ; Pregnancy ; Pregnancy, Multiple
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Choline, a vital amine (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-08-26
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blusztajn, J K -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):794-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA. jbluszta@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9714685" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/metabolism ; Aging ; Animals ; Apoptosis ; Brain/cytology/*embryology/growth & development/*physiology ; Cell Division ; Choline/*administration & dosage/*metabolism ; Choline Deficiency/physiopathology ; Cognition ; Diet ; Female ; Hippocampus/metabolism ; Humans ; Long-Term Potentiation ; Maternal-Fetal Exchange ; Memory ; Nutrition Policy ; Pregnancy ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 62
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    HIV vaccine trials (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1998-03-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalebic, T -- New York, N.Y. -- Science. 1998 Mar 6;279(5356):1434-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9508712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/therapeutic use ; Controlled Clinical Trials as Topic/*standards ; *Developing Countries ; *Ethics, Medical ; Female ; HIV Infections/*drug therapy/prevention & control/transmission ; Humans ; Placebos ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Socioeconomic Factors ; Zidovudine/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 63
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    Bangkok study adds fuel to AIDS ethics debate (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1997-12-31
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, J -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1553.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9411773" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anti-HIV Agents/*therapeutic use ; Controlled Clinical Trials as Topic ; Ethics, Medical ; Female ; HIV Infections/*drug therapy/transmission ; Humans ; Infant ; Infectious Disease Transmission, Vertical ; *Placebos ; Pregnancy ; Pregnancy Complications, Infectious/*drug therapy ; Pregnant Women ; Thailand ; Zidovudine/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 64
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    Expression of T cell antigen receptor heterodimers in a lipid-linked form (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-08-10
    Beschreibung: The interaction of the T cell receptor for antigen (TCR) with its antigen-major histocompatibility complex ligand is difficult to study because both are cell surface multimers. The TCR consists of two chains (alpha and beta) that are complexed to the five or more nonpolymorphic CD3 polypeptides. A soluble form of the TCR was engineered by replacing the carboxyl termini of alpha and beta with signal sequences from lipid-linked proteins, making them susceptible to enzymatic cleavage. In this manner, TCR heterodimers can be expressed independently of the CD3 polypeptides and in significant quantities (0.5 milligram per week). This technique seems generalizable to biochemical and structural studies of many other cell surface molecules as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, A Y -- Devaux, B -- Green, A -- Sagerstrom, C -- Elliott, J F -- Davis, M M -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):677-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1696397" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkaline Phosphatase/genetics ; Amino Acid Sequence ; Animals ; Antigens, CD3 ; Antigens, CD55 ; Antigens, Differentiation, T-Lymphocyte/genetics ; Cell Line ; Complement Inactivator Proteins/genetics ; Female ; Humans ; Macromolecular Substances ; Membrane Proteins/genetics ; Molecular Sequence Data ; Placenta/enzymology ; Pregnancy ; Protein Sorting Signals/genetics ; Receptors, Antigen, T-Cell/*genetics ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 65
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    Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-05-04
    Beschreibung: The amino acid sequences of three fragments of cyanogen bromide-digested human placental inositol 1,2-cyclic phosphate 2-phosphohydrolase, an enzyme of the phosphatidylinositol signaling pathway, are identical to sequences within lipocortin III, a member of a family of homologous calcium- and phospholipid-binding proteins that do not have defined physiological functions. Lipocortin III has also been previously identified as placental anticoagulant protein III (PAP III) and calcimedin 35 alpha. Antibodies to PAP III detected PAP III and inositol 1,2-cyclic phosphate 2-phosphohydrolase with identical reactivity on immunoblotting. In addition, inositol 1,2-cyclic phosphate 2-phosphohydrolase was stimulated by the same acidic phospholipids that bind lipocortins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, T S -- Tait, J F -- Majerus, P W -- HLBI 14147/HL/NHLBI NIH HHS/ -- HLBI 16634/HL/NHLBI NIH HHS/ -- HLBI 40801/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1990 May 4;248(4955):605-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2159184" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Annexin A3 ; Annexins ; Calcium-Binding Proteins/*genetics ; Female ; Humans ; Immunoblotting ; Kinetics ; Molecular Sequence Data ; Phosphoric Diester Hydrolases/*genetics/isolation & purification/metabolism ; Placenta/*enzymology ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    Psychological responses after abortion (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-04-06
    Beschreibung: A review of methodologically sound studies of the psychological responses of U.S. women after they obtained legal, nonrestrictive abortions indicates that distress is generally greatest before the abortion and that the incidence of severe negative responses is low. Factors associated with increased risk of negative response are consistent with those reported in research on other stressful life events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, N E -- David, H P -- Major, B N -- Roth, S H -- Russo, N F -- Wyatt, G E -- New York, N.Y. -- Science. 1990 Apr 6;248(4951):41-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2181664" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Induced/*psychology ; Adaptation, Psychological ; Adolescent ; Emotions ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, First ; *Pregnant Women ; Risk Assessment ; Social Support ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 67
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    Reproductive behavior and health in consanguineous marriages (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-05-10
    Beschreibung: In many regions of Asia and Africa, consanguineous marriages currently account for approximately 20 to 50% of all unions, and preliminary observations indicate that migrants from these areas continue to contract marriages with close relatives when resident in North America and Western Europe. Consanguinity is associated with increased gross fertility, due at least in part to younger maternal age at first livebirth. Morbidity and mortality also may be elevated, resulting in comparable numbers of surviving offspring in consanguineous and nonconsanguineous families. With advances in medicine and public health, genetic disorders will account for an increased proportion of disease worldwide. Predictably, this burden will fall more heavily on countries and communities in which consanguinity is strongly favored, as the result of the expression of deleterious recessive genes. However, studies conducted in such populations indicate that the adverse effects associated with inbreeding are experienced by a minority of families.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bittles, A H -- Mason, W M -- Greene, J -- Rao, N A -- New York, N.Y. -- Science. 1991 May 10;252(5007):789-94.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉King's College, University of London.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2028254" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Congenital Abnormalities/epidemiology ; *Consanguinity ; Female ; Humans ; India ; Infertility ; Marriage ; Maternal Age ; Parity ; Pregnancy ; Pregnancy Outcome ; Regression Analysis ; Sexual Behavior/*statistics & numerical data
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 68
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    Improvements seen for RU-486 abortions (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maurice, J -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):198, 200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925574" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Induced ; Female ; Humans ; Internationality ; Mifepristone/*therapeutic use ; Pregnancy ; Pregnant Women ; *Risk Assessment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 69
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    FISHing cuts the angst in amniocentesis (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-10-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roberts, L -- New York, N.Y. -- Science. 1991 Oct 18;254(5030):378-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925595" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; *Genetic Techniques ; Humans ; *Nucleic Acid Hybridization ; Pregnancy ; Prenatal Diagnosis/*methods ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 70
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    Feminist group dissents on RU-486 use for abortion (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-10-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffman, M -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):199.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925575" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Induced ; Female ; Humans ; Mifepristone/*therapeutic use ; Pregnancy ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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    Abortion stirs the neuroscience gumbo (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barinaga, M -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):514.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948022" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Legal ; *Ethics, Professional ; Female ; Humans ; Louisiana ; *Neurology ; Pregnancy ; *Societies, Scientific ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 72
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    Changes in the sensory processing of olfactory signals induced by birth in sheep (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-05-08
    Beschreibung: After giving birth, sheep and many other species form a selective bond with their offspring based on the sense of smell. Processing of olfactory signals is altered to allow the animals to perform this selective recognition. Lamb odors have little effect on either neurotransmitter release or electrical activity of neurons in the olfactory bulb before birth. However, after birth there is an increase in the number of mitral cells, the principal cells of the olfactory bulb, that respond to lamb odors, which is associated with increased cholinergic and noradrenergic neurotransmitter release. Selective recognition of lambs is accompanied by increased activity of a subset of mitral cells and release of glutamate and gamma-aminobutyric acid (GABA) from the dendrodendritic synapses between the mitral and granule cells. The relation between the release of each transmitter after birth also suggests an increased efficacy of glutamate-evoked GABA release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kendrick, K M -- Levy, F -- Keverne, E B -- New York, N.Y. -- Science. 1992 May 8;256(5058):833-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Agricultural and Food Research Council, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1589766" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Female ; Glutamates/secretion ; Labor, Obstetric ; *Maternal Behavior ; Models, Neurological ; Neurons/physiology ; Odors ; Olfactory Bulb/*physiology ; Olfactory Nerve/physiology ; Pregnancy ; Regression Analysis ; Sheep ; *Smell ; Time Factors ; gamma-Aminobutyric Acid/secretion
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 73
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    Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-02-28
    Beschreibung: Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolinsky, S M -- Wike, C M -- Korber, B T -- Hutto, C -- Parks, W P -- Rosenblum, L L -- Kunstman, K J -- Furtado, M R -- Munoz, J L -- AI-32535/AI/NIAID NIH HHS/ -- HD26619-01/HD/NICHD NIH HHS/ -- P01-25569/PHS HHS/ -- New York, N.Y. -- Science. 1992 Feb 28;255(5048):1134-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1546316" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/congenital/microbiology/*transmission ; Amino Acid Sequence ; Base Sequence ; Female ; Genotype ; Glycosylation ; HIV Antigens/genetics ; HIV Envelope Protein gp120/genetics/immunology ; HIV-1/*genetics/immunology ; Humans ; Infant ; Maternal-Fetal Exchange ; Molecular Sequence Data ; Oligodeoxyribonucleotides/chemistry ; Polymerase Chain Reaction ; Pregnancy ; Selection, Genetic ; Sequence Alignment
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 74
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    The Molecule of the Year (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1989-12-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guyer, R L -- Koshland, D E Jr -- New York, N.Y. -- Science. 1989 Dec 22;246(4937):1543-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2688087" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Induced ; Cystic Fibrosis/genetics ; DNA/*genetics ; DNA-Directed DNA Polymerase ; Female ; *Genetic Techniques ; Humans ; Microscopy, Electron, Scanning ; Mifepristone ; Nucleic Acid Amplification Techniques ; Pregnancy ; Research/*trends
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 75
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    A class I antigen, HLA-G, expressed in human trophoblasts (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-04-13
    Beschreibung: The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kovats, S -- Main, E K -- Librach, C -- Stubblebine, M -- Fisher, S J -- DeMars, R -- AI-15586/AI/NIAID NIH HHS/ -- HD-24495/HD/NICHD NIH HHS/ -- P0I HD-24180/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Apr 13;248(4952):220-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Oncology, University of Wisconsin, Madison 53706.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2326636" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Monoclonal ; Cell Line ; Choriocarcinoma/immunology ; Female ; Gene Expression ; *Genes, MHC Class I ; HLA Antigens/*genetics ; HLA-G Antigens ; Histocompatibility Antigens Class I/*genetics ; Humans ; Macromolecular Substances ; Pregnancy ; Pregnancy Trimester, First ; Trophoblasts/*immunology ; Tumor Cells, Cultured/immunology ; Uterine Neoplasms/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 76
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    Olfactory recognition: a simple memory system (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-11-30
    Beschreibung: Mice have an olfactory (pheromone) recognition memory located at the first relay in the sensory system. It is acquired with one-trial learning, contingent upon norepinephrine activation at mating, and lasts for several weeks. The mechanism involves Hebbian (association-dependent) changes in synaptic efficacy at dendrodendritic synapses in the accessory olfactory bulb. As a result of this memory, males made familiar by mating are recognized by the females, thereby mitigating pregnancy block. Such a memory function is biologically important to the female, as it is required to sustain pregnancy in the presence of her stud male's odors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brennan, P -- Kaba, H -- Keverne, E B -- New York, N.Y. -- Science. 1990 Nov 30;250(4985):1223-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sub-Department of Animal Behaviour, University of Cambridge, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2147078" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amygdala/drug effects/physiology ; Animals ; Female ; Hypothalamus/physiology ; Lidocaine/pharmacology ; Male ; Memory/*physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; N-Methylaspartate/antagonists & inhibitors/physiology ; Norepinephrine/physiology ; Olfactory Bulb/drug effects/physiology ; Olfactory Pathways/drug effects/physiology ; *Pheromones/urine ; Pregnancy ; Pregnancy, Animal/*physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; Reproduction/physiology ; Smell/*physiology ; Synapses/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 77
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    Effect of light chain V region duplication on IgG oligomerization and in vivo efficacy (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-05-03
    Beschreibung: A human immunoglobulin G1 (IgG1) antibody oligomer was isolated from a transfected myeloma cell line that produced a monoclonal antibody to group B streptococci. Compared to the IgG1 monomer, the oligomer was significantly more effective at protecting neonatal rats from infection in vivo. The oligomer was also shown to cross the placenta and to be stable in neonatal rats. Immunochemical analysis and complementary DNA sequencing showed that the transfected cell line produced two distinct kappa light chains: a normal light chain (Ln) with a molecular mass of 25 kilodaltons and a 37-kilodalton species (L37), the domain composition of which was variable-variable-constant (V-V-C). Cotransfection of vectors encoding the heavy chain and L37 resulted in production of oligomeric IgG.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shuford, W -- Raff, H V -- Finley, J W -- Esselstyn, J -- Harris, L J -- New York, N.Y. -- Science. 1991 May 3;252(5006):724-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immune Sciences, Bristol-Myers Squibb Pharmaceutical Research Institute-Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1902593" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Antibodies, Bacterial/biosynthesis/immunology/pharmacokinetics ; Antibodies, Monoclonal/biosynthesis/immunology/pharmacokinetics ; Cell Line ; Female ; Humans ; Immunization, Passive ; Immunoglobulin G/*biosynthesis/genetics/immunology ; Immunoglobulin M/genetics ; Immunoglobulin Variable Region/*biosynthesis/genetics/immunology ; Immunoglobulin kappa-Chains/*biosynthesis/genetics/immunology ; Macromolecular Substances ; Maternal-Fetal Exchange ; Multiple Myeloma ; Pregnancy ; Rats ; Streptococcal Infections/prevention & control ; Streptococcus agalactiae/immunology ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 78
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    Folic acid. Agencies split on nutrition advice (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-09-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palca, J -- New York, N.Y. -- Science. 1992 Sep 25;257(5078):1857.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1301026" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Diet ; Female ; *Folic Acid ; Humans ; Neural Tube Defects/prevention & control ; Pregnancy
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 79
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    The tissue bank's shaky underpinnings (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-08-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamilton, D P -- New York, N.Y. -- Science. 1992 Aug 14;257(5072):869.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1502549" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aborted Fetus ; Abortion, Induced ; Abortion, Spontaneous ; Costs and Cost Analysis ; Federal Government ; Female ; *Fetal Research ; *Fetal Tissue Transplantation ; Fetus ; Humans ; National Institutes of Health (U.S.) ; Pregnancy ; Pregnancy, Ectopic ; Tissue Banks/economics/*organization & administration ; United States ; United States Dept. of Health and Human Services
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 80
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    Miscarriage study (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-07-17
    Beschreibung: In the letter of 19 June 1992 (p. 1613) by Ellen C. Weaver and Stephanie J. Bird of the Association for Women in Science (AWIS), an incorrect phone number was given for the AWIS mentoring program. The correct number is 800-886-AWIS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Byrne, J -- New York, N.Y. -- Science. 1992 Jul 17;257(5068):310.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1631547" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Abortion, Spontaneous/*etiology ; Bacterial Infections/complications ; Female ; *Fetal Tissue Transplantation ; Fetus/*microbiology ; Humans ; Pregnancy ; Virus Diseases/complications
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 81
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    Fetal brain signals time for birth (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-09-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palca, J -- New York, N.Y. -- Science. 1991 Sep 20;253(5026):1360.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1896846" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/embryology/*physiology ; *Delivery, Obstetric ; Female ; Fetus/*physiology ; Humans ; Paraventricular Hypothalamic Nucleus/embryology/*physiology ; Pregnancy ; Sheep
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 82
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    Sullivan overrules NIH on sex survey (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-08-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, E -- New York, N.Y. -- Science. 1991 Aug 2;253(5019):502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1857975" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/prevention & control ; Adolescent ; Child ; Female ; *Health Surveys ; Humans ; Interviews as Topic ; Male ; National Institutes of Health (U.S.) ; Pregnancy ; Pregnancy in Adolescence ; *Research Design ; *Sexual Behavior ; United States ; United States Public Health Service/organization & administration
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 83
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    Fetal tissue. Banking for transplantation research (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-05-29
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palca, J -- New York, N.Y. -- Science. 1992 May 29;256(5061):1274.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1598567" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Induced ; *Abortion, Spontaneous ; Congenital Abnormalities ; Female ; *Fetal Tissue Transplantation ; Humans ; National Institutes of Health (U.S.) ; *Politics ; Pregnancy ; Research ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 84
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    Infection with selection: HIV in human infants (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-02-28
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palca, J -- New York, N.Y. -- Science. 1992 Feb 28;255(5048):1069.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1546308" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/congenital/microbiology/*transmission ; Female ; HIV-1/*genetics ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*microbiology ; Maternal-Fetal Exchange ; Pregnancy ; Selection, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 85
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    Analysis of junctional diversity during B lymphocyte development (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-11-09
    Beschreibung: Immunoglobulin rearrangement is central to generating antibody diversity because of heterogeneity generated during recombination by deletion or addition of nucleotides at coding joints by the recombinase machinery. Examination of these junctional modifications revealed that the addition of nongermline-encoded nucleotides was more prevalent in adult versus fetal B cells, thus partially limiting the fetal antibody repertoire. In contrast, deletion of nucleotides occurs equivalently in B cells at different stages of development and at different points in B cell ontogeny. Finally, the bias in murine immunoglobulins for one DH segment reading frame occurs at the DHJH intermediate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meek, K -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):820-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2237433" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging/genetics/immunology ; Animals ; Animals, Newborn ; *Antibody Diversity ; B-Lymphocytes/*immunology ; Blotting, Southern ; Electrophoresis, Polyacrylamide Gel ; Female ; *Gene Rearrangement, B-Lymphocyte ; Immunoglobulin Joining Region/*genetics ; Mice ; Nucleic Acid Hybridization ; Polymerase Chain Reaction ; Pregnancy ; Restriction Mapping
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 86
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    Low-dose radiation exposure (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, R W -- Brent, R L -- New York, N.Y. -- Science. 1990 Mar 9;247(4947):1166.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2315688" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Female ; Humans ; Intellectual Disability/*etiology ; Pregnancy ; *Prenatal Exposure Delayed Effects ; Radiation Dosage ; *Radiation Injuries
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 87
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    Linkage of early-onset familial breast cancer to chromosome 17q21 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-12-21
    Beschreibung: Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible for inherited breast cancer may also allow the identification of early lesions that are critical for the development of breast cancer in the general population. Chromosome 17q21 appears to be the locale of a gene for inherited susceptibility to breast cancer in families with early-onset disease. Genetic analysis yields a lod score (logarithm of the likelihood ratio for linkage) of 5.98 for linkage of breast cancer susceptibility to D17S74 in early-onset families and negative lod scores in families with late-onset disease. Likelihood ratios in favor of linkage heterogeneity among families ranged between 2000:1 and greater than 10(6):1 on the basis of multipoint analysis of four loci in the region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, J M -- Lee, M K -- Newman, B -- Morrow, J E -- Anderson, L A -- Huey, B -- King, M C -- CA27632/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1990 Dec 21;250(4988):1684-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Public Health, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2270482" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Breast Neoplasms/diagnosis/etiology/*genetics ; Chromosome Mapping ; *Chromosomes, Human, Pair 17 ; Female ; Humans ; Male ; Pedigree ; Polymorphism, Genetic ; Pregnancy ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 88
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    HIV risk higher for first-born twins (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-12-20
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palca, J -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1729.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1763322" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*transmission ; *Birth Order ; Cesarean Section ; Delivery, Obstetric ; *Diseases in Twins ; Female ; HIV Infections/*transmission ; Humans ; Labor, Obstetric ; Pregnancy ; Pregnancy Complications, Infectious/physiopathology ; Risk Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 89
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    "Matrix algebra" heals life's wounds (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-05-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skerrett, P J -- New York, N.Y. -- Science. 1991 May 24;252(5009):1064-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2031178" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Extracellular Matrix/physiology ; Female ; Fetal Diseases/therapy ; Growth Substances/*physiology/therapeutic use ; Humans ; Keratinocytes/physiology ; Pregnancy ; Transforming Growth Factor beta/physiology ; Wound Healing/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 90
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    Fetal tissue research (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-07-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koshland, D E Jr -- New York, N.Y. -- Science. 1992 Jun 26;256(5065):1741.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1615314" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aborted Fetus ; *Abortion, Induced ; Animals ; Biomedical Research ; Ethics, Medical ; Female ; *Fetal Research ; *Fetal Tissue Transplantation ; Humans ; Mice ; National Institutes of Health (U.S.)/economics ; Pregnancy ; Research ; *Risk Assessment ; *Tissue and Organ Procurement ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 91
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    Fetal tissue. Congress considers testing Bush's plan (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-07-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1992 Jul 3;257(5066):24-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1621090" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Abortion, Induced ; Diabetes Mellitus/surgery ; Female ; *Fetal Tissue Transplantation ; Humans ; National Institutes of Health (U.S.) ; Parkinson Disease/surgery ; Politics ; Pregnancy ; Research Support as Topic/*legislation & jurisprudence ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 92
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    Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2006-04-08
    Beschreibung: Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-beta (TGF-beta) family of cytokines. We show that aortic aneurysm in a mouse model of MFS is associated with increased TGF-beta signaling and can be prevented by TGF-beta antagonists such as TGF-beta-neutralizing antibody or the angiotensin II type 1 receptor (AT1) blocker, losartan. AT1 antagonism also partially reversed noncardiovascular manifestations of MFS, including impaired alveolar septation. These data suggest that losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with MFS and has the potential to prevent the major life-threatening manifestation of this disorder.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482474/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482474/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Habashi, Jennifer P -- Judge, Daniel P -- Holm, Tammy M -- Cohn, Ronald D -- Loeys, Bart L -- Cooper, Timothy K -- Myers, Loretha -- Klein, Erin C -- Liu, Guosheng -- Calvi, Carla -- Podowski, Megan -- Neptune, Enid R -- Halushka, Marc K -- Bedja, Djahida -- Gabrielson, Kathleen -- Rifkin, Daniel B -- Carta, Luca -- Ramirez, Francesco -- Huso, David L -- Dietz, Harry C -- K08 HL067056/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 7;312(5770):117-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16601194" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenergic beta-Antagonists/administration & dosage/therapeutic use ; Angiotensin II Type 1 Receptor Blockers/administration & dosage/*therapeutic use ; Animals ; Antibodies/immunology ; Aorta/pathology ; Aortic Aneurysm/etiology/*prevention & control ; *Disease Models, Animal ; Elastic Tissue/pathology ; Female ; Losartan/administration & dosage/*therapeutic use ; Lung/pathology ; Lung Diseases/drug therapy/pathology ; Marfan Syndrome/complications/*drug therapy/metabolism/pathology ; Mice ; Microfilament Proteins/genetics ; Mutation ; Neutralization Tests ; Pregnancy ; Pregnancy Complications/drug therapy ; Propranolol/administration & dosage/therapeutic use ; Pulmonary Alveoli/pathology ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; Transforming Growth Factor beta/antagonists & inhibitors/immunology/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
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    The baby deficit (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2006-07-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balter, Michael -- New York, N.Y. -- Science. 2006 Jun 30;312(5782):1894-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16809522" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aging ; *Birth Rate ; *Developed Countries ; Developing Countries ; Emigration and Immigration ; Family Characteristics ; Female ; Humans ; Male ; Parental Leave ; Population Dynamics ; *Population Growth ; Pregnancy ; Public Policy ; *Reproductive Behavior
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    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
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    Neuroscience. Maternal effects on schizophrenia risk (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-10-27
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, Paul H -- New York, N.Y. -- Science. 2007 Oct 26;318(5850):576-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. php@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17962542" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal ; Cytokines/physiology ; Female ; Humans ; Influenza, Human/immunology ; Maternal Exposure ; *Maternal-Fetal Exchange ; Placenta/*physiology ; Pregnancy ; *Pregnancy Complications, Infectious/immunology ; *Prenatal Exposure Delayed Effects ; *Respiratory Tract Infections/immunology ; Risk Factors ; Schizophrenia/*etiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
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    Endocrine disrupters. Controversy continues after panel rules on bisphenol A (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-08-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2007 Aug 17;317(5840):884-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17702917" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Advisory Committees ; Animals ; Benzhydryl Compounds ; Child ; Endocrine Disruptors/administration & dosage/*toxicity ; Female ; Humans ; Male ; Mice ; Phenols/administration & dosage/*toxicity ; Pregnancy ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 96
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    Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-11-03
    Beschreibung: During pregnancy, maternal pancreatic islets grow to match dynamic physiological demands, but the mechanisms regulating adaptive islet growth in this setting are poorly understood. Here we show that menin, a protein previously characterized as an endocrine tumor suppressor and transcriptional regulator, controls islet growth in pregnant mice. Pregnancy stimulated proliferation of maternal pancreatic islet beta-cells that was accompanied by reduced islet levels of menin and its targets. Transgenic expression of menin in maternal beta-cells prevented islet expansion and led to hyperglycemia and impaired glucose tolerance, hallmark features of gestational diabetes. Prolactin, a hormonal regulator of pregnancy, repressed islet menin levels and stimulated beta-cell proliferation. These results expand our understanding of mechanisms underlying diabetes pathogenesis and reveal potential targets for therapy in diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Karnik, Satyajit K -- Chen, Hainan -- McLean, Graeme W -- Heit, Jeremy J -- Gu, Xueying -- Zhang, Andrew Y -- Fontaine, Magali -- Yen, Michael H -- Kim, Seung K -- T32DK007217-32/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Nov 2;318(5851):806-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17975067" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Proliferation ; Diabetes, Gestational/*etiology/metabolism ; Female ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/*physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Obesity/metabolism ; Pregnancy ; Prolactin/metabolism ; Proto-Oncogene Proteins/*physiology ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
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    Medicine. Tumor suppressor may also affect gestational diabetes (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-11-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2007 Nov 2;318(5851):729.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17975038" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Diabetes, Gestational/*metabolism ; Female ; Humans ; Insulin-Secreting Cells/cytology ; Mice ; Pregnancy ; Prolactin/physiology ; Proto-Oncogene Proteins/genetics/*physiology ; Tumor Suppressor Proteins/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
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    Comment on "Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery" (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-07-14
    Beschreibung: Tyzio et al. (Reports, 15 December 2006, p. 1788) reported that maternal oxytocin triggers a transient excitatory-to-inhibitory switch of gamma-aminobutyric acid (GABA) signaling during labor, thus protecting the fetal rat brain from anoxic injury. However, a body of evidence supports the possibility that oxytocin is released from the fetal pituitary during delivery, not only from the mother, particularly under conditions of hypoxic stress.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carbillon, Lionel -- New York, N.Y. -- Science. 2007 Jul 13;317(5835):197; author reply 197.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Obstetrics and Gynecology, Assistance Publique-Hopitaux de Paris, Paris 13 University, Hopital Jean Verdier, Avenue du 14 Juillet, 93143 Bondy Cedex, France. lionel.carbillon@jvr.aphp.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17626868" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Brain/*embryology/metabolism ; Female ; Fetal Hypoxia/physiopathology/prevention & control ; Fetus/*metabolism ; Hippocampus/embryology/metabolism ; Oxytocin/metabolism/*physiology ; *Parturition ; Pituitary Gland/embryology/metabolism ; Pregnancy ; Rats ; *Signal Transduction ; gamma-Aminobutyric Acid/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
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    Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2008-12-06
    Beschreibung: As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self-reactive cells. Here, we show that the human fetal immune system takes advantage of an additional mechanism: the generation of regulatory T cells (Tregs) that suppress fetal immune responses. We find that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of CD4+CD25highFoxP3+ Tregs that suppress fetal antimaternal immunity and persist at least until early adulthood. These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648820/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648820/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mold, Jeff E -- Michaelsson, Jakob -- Burt, Trevor D -- Muench, Marcus O -- Beckerman, Karen P -- Busch, Michael P -- Lee, Tzong-Hae -- Nixon, Douglas F -- McCune, Joseph M -- AI40312/AI/NIAID NIH HHS/ -- AI68498/AI/NIAID NIH HHS/ -- DP1 OD000329/OD/NIH HHS/ -- DP1 OD000329-01/OD/NIH HHS/ -- DP1 OD000329-02/OD/NIH HHS/ -- DP1 OD000329-03/OD/NIH HHS/ -- DP1 OD000329-04/OD/NIH HHS/ -- HD00850/HD/NICHD NIH HHS/ -- HL083388/HL/NHLBI NIH HHS/ -- OD000329/OD/NIH HHS/ -- R01 HL083388/HL/NHLBI NIH HHS/ -- R01 HL083388-02/HL/NHLBI NIH HHS/ -- R37 AI040312/AI/NIAID NIH HHS/ -- R37 AI040312-09/AI/NIAID NIH HHS/ -- R37 AI040312-10/AI/NIAID NIH HHS/ -- R37 AI040312-11/AI/NIAID NIH HHS/ -- R37 AI040312-12/AI/NIAID NIH HHS/ -- R37 AI040312-13/AI/NIAID NIH HHS/ -- RR024131/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1562-5. doi: 10.1126/science.1164511.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Experimental Medicine, Department of Medicine, University of California at San Francisco (UCSF), San Francisco, CA 94110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056990" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Antigen-Presenting Cells/immunology ; Cells, Cultured ; Child ; Chimerism ; Female ; Fetus/*immunology ; Forkhead Transcription Factors/metabolism ; Gene Expression Profiling ; Humans ; *Immune Tolerance ; Isoantigens/*immunology ; Lymph Nodes/cytology/*immunology ; Lymphocyte Activation ; *Maternal-Fetal Exchange ; Pregnancy ; Self Tolerance ; T-Lymphocytes, Regulatory/*immunology ; Thymus Gland/immunology ; Transforming Growth Factors/genetics/metabolism ; Tumor Necrosis Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
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    Retrovirus meeting. Back-to-basics push as HIV prevention struggles (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2008-02-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2008 Feb 15;319(5865):888. doi: 10.1126/science.319.5865.888.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276859" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *AIDS Vaccines ; Animals ; Anti-HIV Agents/therapeutic use ; Female ; *HIV/genetics/pathogenicity ; *HIV Infections/immunology/prevention & control/transmission/virology ; Humans ; Infant ; Pregnancy ; Pregnancy Complications, Infectious/virology ; T-Lymphocyte Subsets/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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