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  • 1
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    Pseudotypes in HIV-infected mice (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-11-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- Namikawa, R -- Shih, C C -- Rabin, L -- Kaneshima, H -- New York, N.Y. -- Science. 1990 Nov 23;250(4984):1152-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2174574" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Containment of Biohazards ; *Disease Models, Animal ; HIV/*genetics/pathogenicity ; HIV Infections/*microbiology ; Immunologic Deficiency Syndromes/*microbiology ; Leukemia Virus, Murine/*genetics/physiology ; Mice ; Mice, Mutant Strains ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Suppression of HIV infection in AZT-treated SCID-hu mice (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-02-02
    Description: The SCID-hu mouse, engrafted with human hematolymphoid organs, is permissive for infection with the human immunodeficiency virus (HIV). This mouse model was used to test compounds for antiviral efficacy. Two weeks after infection with HIV, 100 percent (40/40) of SCID-hu mice were positive for HIV by the polymerase chain reaction. When first treated with 3'-azido-3'-deoxythymidine (AZT), none (0/17) were HIV-positive by this assay. However, AZT-treated SCID-hu mice did have a few infected cells; after AZT treatment was stopped, viral spread was detected by polymerase chain reaction in such mice. Thus, the SCID-hu mouse provides a means to directly compare new antiviral compounds with AZT and to further improve antiviral efficacy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- Namikawa, R -- Shih, C C -- Rabin, L -- Kaneshima, H -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):564-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉HIV Group, SyStemix, Palo Alto, CA 94303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2300816" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Viral/genetics/isolation & purification ; HIV/drug effects/genetics/isolation & purification ; HIV Infections/*drug therapy ; Humans ; Mice ; Mice, Mutant Strains ; Nucleic Acid Hybridization ; Polymerase Chain Reaction ; Spleen/microbiology ; Thymus Gland/microbiology/transplantation ; Transplantation, Heterologous ; Zidovudine/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-12-06
    Description: As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self-reactive cells. Here, we show that the human fetal immune system takes advantage of an additional mechanism: the generation of regulatory T cells (Tregs) that suppress fetal immune responses. We find that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of CD4+CD25highFoxP3+ Tregs that suppress fetal antimaternal immunity and persist at least until early adulthood. These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648820/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648820/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mold, Jeff E -- Michaelsson, Jakob -- Burt, Trevor D -- Muench, Marcus O -- Beckerman, Karen P -- Busch, Michael P -- Lee, Tzong-Hae -- Nixon, Douglas F -- McCune, Joseph M -- AI40312/AI/NIAID NIH HHS/ -- AI68498/AI/NIAID NIH HHS/ -- DP1 OD000329/OD/NIH HHS/ -- DP1 OD000329-01/OD/NIH HHS/ -- DP1 OD000329-02/OD/NIH HHS/ -- DP1 OD000329-03/OD/NIH HHS/ -- DP1 OD000329-04/OD/NIH HHS/ -- HD00850/HD/NICHD NIH HHS/ -- HL083388/HL/NHLBI NIH HHS/ -- OD000329/OD/NIH HHS/ -- R01 HL083388/HL/NHLBI NIH HHS/ -- R01 HL083388-02/HL/NHLBI NIH HHS/ -- R37 AI040312/AI/NIAID NIH HHS/ -- R37 AI040312-09/AI/NIAID NIH HHS/ -- R37 AI040312-10/AI/NIAID NIH HHS/ -- R37 AI040312-11/AI/NIAID NIH HHS/ -- R37 AI040312-12/AI/NIAID NIH HHS/ -- R37 AI040312-13/AI/NIAID NIH HHS/ -- RR024131/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2008 Dec 5;322(5907):1562-5. doi: 10.1126/science.1164511.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Experimental Medicine, Department of Medicine, University of California at San Francisco (UCSF), San Francisco, CA 94110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19056990" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Antigen-Presenting Cells/immunology ; Cells, Cultured ; Child ; Chimerism ; Female ; Fetus/*immunology ; Forkhead Transcription Factors/metabolism ; Gene Expression Profiling ; Humans ; *Immune Tolerance ; Isoantigens/*immunology ; Lymph Nodes/cytology/*immunology ; Lymphocyte Activation ; *Maternal-Fetal Exchange ; Pregnancy ; Self Tolerance ; T-Lymphocytes, Regulatory/*immunology ; Thymus Gland/immunology ; Transforming Growth Factors/genetics/metabolism ; Tumor Necrosis Factors/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Animal models of HIV-1 disease (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- New York, N.Y. -- Science. 1997 Dec 19;278(5346):2141-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, University of California, San Francisco 94110-9100, USA. mike_mccune.giv@quickmail.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9432722" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-HIV Agents/pharmacology ; *Disease Models, Animal ; Genetic Therapy ; *HIV Infections/drug therapy/therapy/virology ; *HIV-1/drug effects/physiology ; Hematopoiesis ; Humans ; Lentivirus Infections ; Mice ; Mice, SCID ; Mice, Transgenic ; Thymus Gland/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Public health. A sound rationale needed for phase III HIV-1 vaccine trials (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, Dennis R -- Desrosiers, Ronald C -- Doms, Robert W -- Feinberg, Mark B -- Gallo, Robert C -- Hahn, Beatrice -- Hoxie, James A -- Hunter, Eric -- Korber, Bette -- Landay, Alan -- Lederman, Michael M -- Lieberman, Judy -- McCune, Joseph M -- Moore, John P -- Nathanson, Neal -- Picker, Louis -- Richman, Douglas -- Rinaldo, Charles -- Stevenson, Mario -- Watkins, David I -- Wolinsky, Steven M -- Zack, Jerome A -- New York, N.Y. -- Science. 2004 Jan 16;303(5656):316.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Research Institute, La Jolla, California, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14726576" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*immunology ; *Clinical Trials, Phase III as Topic/economics ; Costs and Cost Analysis ; HIV Envelope Protein gp120/*immunology ; HIV Infections/*immunology/prevention & control/therapy ; HIV-1/*immunology ; Humans ; Immunization Schedule ; Immunization, Secondary ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Thailand ; United States ; Vaccines, Synthetic/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Infection of the SCID-hu mouse by HIV-1 (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-12-23
    Description: SCID-hu mice with human fetal thymic or lymph node implants were inoculated with the cloned human immunodeficiency virus-1 isolate, HIV-1JR-CSF. In a time- and dose-dependent fashion, viral replication spread within the human lymphoid organs. Combination immunohistochemistry and in situ hybridization revealed only viral RNA transcripts in most infected cells, but some cells had both detectable viral transcripts and viral protein. Infected cells were always more apparent in the medulla than in the cortex of the thymus. These studies demonstrate that an acute infection of human lymphoid organs with HIV-1 can be followed in the SCID-hu mouse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Namikawa, R -- Kaneshima, H -- Lieberman, M -- Weissman, I L -- McCune, J M -- AR5P40RR03624-029/AR/NIAMS NIH HHS/ -- CA03352/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Dec 23;242(4886):1684-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3201256" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome ; Animals ; Chimera ; *Disease Models, Animal ; HIV/genetics/*physiology ; Humans ; Immunohistochemistry ; Lymph Nodes/microbiology/transplantation ; Mice ; Mice, Mutant Strains ; Nucleic Acid Hybridization ; RNA, Viral/genetics ; Thymus Gland/microbiology/transplantation ; Transcription, Genetic ; Viral Proteins/biosynthesis ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-23
    Description: The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- Namikawa, R -- Kaneshima, H -- Shultz, L D -- Lieberman, M -- Weissman, I L -- AI09072/AI/NIAID NIH HHS/ -- CA03352/CA/NCI NIH HHS/ -- CA20408/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 23;241(4873):1632-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2971269" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/physiology ; Cell Differentiation ; *Chimera ; Hematopoietic Stem Cells/*physiology ; Humans ; Liver/cytology ; Liver Transplantation ; Lymph Nodes/transplantation ; Mice ; Mice, Mutant Strains/*immunology ; *Models, Biological ; T-Lymphocytes/physiology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland/anatomy & histology/physiology/transplantation ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    A plea for justice for jailed medical workers (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahuja, Sunil K -- Aiuti, Fernando -- Berkhout, Ben -- Biberfeld, Peter -- Burton, Dennis R -- Colizzi, Vittorio -- Deeks, Steven G -- Desrosiers, Ronald C -- Dierich, Manfred P -- Doms, Robert W -- Emerman, Michael -- Gallo, Robert C -- Girard, Marc -- Greene, Warner C -- Hoxie, James A -- Hunter, Eric -- Klein, George -- Korber, Bette -- Kuritzkes, Daniel R -- Lederman, Michael M -- Malim, Michael H -- Marx, Preston A -- McCune, Joseph M -- McMichael, Andrew -- Miller, Christopher -- Miller, Veronica -- Montagnier, Luc -- Montefiori, David C -- Moore, John P -- Nixon, Douglas F -- Overbaugh, Julie -- Pauza, C David -- Richman, Douglas D -- Saag, Michael S -- Sattentau, Quentin -- Schooley, Robert T -- Shattock, Robin -- Shaw, George M -- Stevenson, Mario -- Trkola, Alexandra -- Wainberg, Mark A -- Weiss, Robin A -- Wolinsky, Steven -- Zack, Jerome A -- New York, N.Y. -- Science. 2006 Nov 10;314(5801):924-5. Epub 2006 Oct 24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17062652" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Disease Outbreaks ; HIV Infections/*epidemiology/transmission ; Hiv-1 ; Health Personnel/*legislation & jurisprudence ; Humans ; Jurisprudence ; Libya/epidemiology ; *Prisoners ; *Social Justice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-12-18
    Description: Although the mammalian immune system is generally thought to develop in a linear fashion, findings in avian and murine species argue instead for the developmentally ordered appearance (or "layering") of distinct hematopoietic stem cells (HSCs) that give rise to distinct lymphocyte lineages at different stages of development. Here we provide evidence of an analogous layered immune system in humans. Our results suggest that fetal and adult T cells are distinct populations that arise from different populations of HSCs that are present at different stages of development. We also provide evidence that the fetal T cell lineage is biased toward immune tolerance. These observations offer a mechanistic explanation for the tolerogenic properties of the developing fetus and for variable degrees of immune responsiveness at birth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276679/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276679/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mold, Jeff E -- Venkatasubrahmanyam, Shivkumar -- Burt, Trevor D -- Michaelsson, Jakob -- Rivera, Jose M -- Galkina, Sofiya A -- Weinberg, Kenneth -- Stoddart, Cheryl A -- McCune, Joseph M -- AG033314/AG/NIA NIH HHS/ -- AI40312/AI/NIAID NIH HHS/ -- CA049605/CA/NCI NIH HHS/ -- DP1 OD000329/OD/NIH HHS/ -- DP1 OD000329-05/OD/NIH HHS/ -- N01-AI-70002/AI/NIAID NIH HHS/ -- OD000329/OD/NIH HHS/ -- OD00329/OD/NIH HHS/ -- R37 AI040312/AI/NIAID NIH HHS/ -- R37 AI040312-15/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 17;330(6011):1695-9. doi: 10.1126/science.1196509.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94143-1234, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21164017" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Adult Stem Cells/cytology/physiology ; Aging/immunology ; Animals ; Bone Marrow/embryology ; Bone Marrow Cells ; CD4-Positive T-Lymphocytes/immunology ; *Cell Lineage ; Cytoprotection ; Fetus/cytology/*immunology ; Gene Expression ; Hematopoietic Stem Cells/*physiology ; Humans ; *Immune Tolerance ; Liver/cytology/embryology ; Lymphocyte Activation ; Lymphopoiesis ; Mice ; Mice, SCID ; Oligonucleotide Array Sequence Analysis ; T-Lymphocyte Subsets/immunology/physiology ; T-Lymphocytes/*immunology/*physiology ; T-Lymphocytes, Regulatory/*immunology/physiology ; Thymus Gland/cytology/immunology ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
    Electronic Resource
    Electronic Resource
    Today's SCID-hu mouse (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 561-562 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE haematolymphoid system of the laboratory mouse has been extensively explored. Nevertheless, it is difficult to extrapolate findings made in the mouse to events as they occur in man. First, one cannot be certain that concordant physiological and pathophysiological attributes will be shared and, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348561a0
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