Publication Date:
1988-09-23
Description:
The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- Namikawa, R -- Kaneshima, H -- Shultz, L D -- Lieberman, M -- Weissman, I L -- AI09072/AI/NIAID NIH HHS/ -- CA03352/CA/NCI NIH HHS/ -- CA20408/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 23;241(4873):1632-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2971269" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/physiology
;
Cell Differentiation
;
*Chimera
;
Hematopoietic Stem Cells/*physiology
;
Humans
;
Liver/cytology
;
Liver Transplantation
;
Lymph Nodes/transplantation
;
Mice
;
Mice, Mutant Strains/*immunology
;
*Models, Biological
;
T-Lymphocytes/physiology
;
T-Lymphocytes, Helper-Inducer/immunology
;
T-Lymphocytes, Regulatory/immunology
;
Thymus Gland/anatomy & histology/physiology/transplantation
;
Transplantation, Heterologous
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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