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  • Chemistry  (101,586)
  • AERODYNAMICS  (4,300)
  • 1995-1999  (38,552)
  • 1980-1984  (35,806)
  • 1975-1979  (31,528)
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  • 1
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    Picosecond chemical and biological events (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentzepis, P M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):174-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694523" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Electrons ; *Kinetics ; Lasers ; Protons ; *Retinal Pigments ; *Rhodopsin ; Spectrum Analysis/*methods ; Temperature ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Rational approaches to chemotherapy: antisickling agents (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Phase transition and crystal structure of the 37 degrees C form of cholesterol (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cytochrome a3 structure in carbon monoxide-bound cytochrome oxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 7
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    Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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  • 8
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    Amphiphilic secondary structure: design of peptide hormones (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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  • 9
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    Fourier transform mass spectrometry (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 10
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    Studying enzyme mechanism by 13C nuclear magnetic resonance (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 11
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    What is the risk from chlorofluorocarbons? (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Pyrolysis mass spectrometry of complex organic materials (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 13
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    Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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  • 14
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    beta-Carotene: an unusual type of lipid antioxidant (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 15
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 16
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    Phenylalanine transfer RNA: molecular dynamics simulation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 17
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    Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 18
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    Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 20
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    DNA-binding proteins (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 21
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    A nitrogen pressure of 50 atmospheres does not prevent evolution of hydrogen by nitrogenase (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Foreign aid support of science and economic growth (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    Nonvolatile mutagens in drinking water: production by chlorination and destruction by sulfite (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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    Automated synthesis of gene fragments (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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    Chitin: New facets of research (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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    DNA sequencing and gene structure (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 27
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Reversible chemical modification of the scrapie agent (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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  • 29
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    Nonenzymatic browning in vivo: possible process for aging of long-lived proteins (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    The National Science Foundation looks to the future (1981)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 32
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Antiviral agents (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Metastable species of hemoglobin: room temperature transients and cryogenically trapped intermediates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 35
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 36
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    The glycosylation of hemoglobin: relevance to diabetes mellitus (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Gabbay, K H -- Gallop, P M -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):21-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635569" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Glucose/metabolism ; Chemical Phenomena ; Chemistry ; Diabetes Complications ; Diabetes Mellitus/*blood/diagnosis ; Diphosphoglyceric Acids/blood ; Glycosides/blood ; Glycosuria/etiology ; Hemoglobin A/*metabolism ; Hemoglobins/*analysis/*metabolism ; Humans ; Kinetics ; Oxygen/blood ; Structure-Activity Relationship
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 37
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    N-formyliminodiacetic acid, a new compound from the reaction of nitrilotriacetic acid and chlorine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 38
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    HCN did not condense to give heteropolypeptides on the primitive earth (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Trace chemistries of fire: a source of chlorinated dioxins (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 40
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    Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 41
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    Curved-flow, rolling-flow, and oscillatory pure-yawing wind-tunnel test methods for determination of dynamic stability derivatives (1981)
    In:  CASI
    Details
    Publication Date: 2011-10-14
    Description: The test capabilities of the Stability Wind Tunnel of the Virginia Polytechnic Institute and State University are described, and calibrations for curved and rolling flow techniques are given. Oscillatory snaking tests to determine pure yawing derivatives are considered. Representative aerodynamic data obtained for a current fighter configuration using the curved and rolling flow techniques are presented. The application of dynamic derivatives obtained in such tests to the analysis of airplane motions in general, and to high angle of attack flight conditions in particular, is discussed.
    Keywords: AERODYNAMICS
    Type: AGARD Dyn. Stability Parameters; 13 p
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  • 42
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    Buffeting tests in a cryogenic windtunnel (1995)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Measurements of wing buffeting, using root strain gages, were made in the NASA Langley 0.3 m cryogenic wind tunnel to refine techniques which will be used in larger cryogenic facilities such as the United States National Transonic Facility (NTF) and the European Transonic Wind Tunnel (ETW). The questions addressed included the relative importance variations in frequency parameter and Reynolds number, the choice of model material (considering both stiffness and damping) and the effects of static aeroelastic distortion. The main series of tests was made on three half models of slender 65 deg delta wings with a sharp leading edge. The three delta wings had the same planform but widely differing bending stiffnesses and frequencies (obtained by varying both the material and the thickness of the wings). It was known that the steady flow on this configuration would be insensitive to variations in Reynolds number. On this wing at vortex breakdown the spectrum of the unsteady excitation is unusual, having a sharp peak at particular frequency parameter. Additional tests were made on one unswept half-wing of aspect ratio 1.5 with an NPL 9510 aerofoil section, known to be sensitive to variations in Reynolds number at transonic speeds. The test Mach numbers were M = 0.21 and 0.35 for the delta wings and to M = 0.30 for the unswept wing. On this wing the unsteady excitation spectrum is fairly flat (as on most wings). Hence correct representation of the frequency parameter is not particularly important.
    Keywords: AERODYNAMICS
    Type: Aeronautical Journal (ISSN 0001-9240); 99; 981; p. 1-14
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  • 43
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    Economy of flight at supersonic speeds (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: Prandtl's theory is used to determine the airflow over bodies and wings adapted to supersonic flight. By making use of these results, and by incorporating in them an allowance for the probable skin friction, some estimates of expected lift-drag ratios are made for various flight speeds with the best configuration. At each speed a slender body and wings having the best angle of sweepback are considered. For the range of supersonic speeds shown an airplane of normal density and loading would be required to operate at an altitude of the order of 60,000 feet. The limiting value of 1-1/2 times the speed of sound corresponds to a flight speed of 1000 miles per hour. At this speed about 1.5 miles per gallon of fuel are expected. It is interesting to note that this value corresponds to a value of more than 15 miles per gallon when the weight is reduced to correspond to that of an ordinary automobile.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 499-514
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  • 44
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    Aeroelastic characteristics of an oblique wing (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: In theory, the most efficient wing shape for transonic and low supersonic speeds is simply a long narrow straight subsonic wing turned at an oblique angle to the flight direction. This theory has been verified by tests at Mach numbers from .6 to 1.4 in supersonic wind tunnel and by comparative studies of transonic transport designs.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 867-883
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  • 45
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    Aerodynamic design for supersonic speeds (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: Recent theoretical and experimental work in supersonic aerodynamics is reviewed with its practical application in mind. Several arrangements of supporting surfaces and bodies are discussed and in some cases comparisons of theory and experiment are made. Finally, certain phenomena connected with lift and drag in a rarefied medium are considered briefly.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 625-644
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  • 46
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    Theoretical determination of the minimum drag of airfoils at supersonic speeds (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: A method is reported for determining mathematically the combined disturbance field, and in certain cases the minimum drag, of wings at supersonic speeds. The simplest analytic example is provided by the wing of elliptic planform, which achieves its minimum drag when the lift is distributed uniformly over the surface. With a symmetrical distribution of thickness, the requirement of minimum drag for a given total volume is found to lead to profiles of constant curvature.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 567-578
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  • 47
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    The minimum drag of thin wings in frictionless flow (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: The assumptions of the thin airfoil theory are found to provide certain necessary conditions for the minimum drag of airfoils having a given total lift, a given maximum thickness, or a given volume. The conditions are applicable to steady or unsteady motions and to subsonic or supersonic speeds without restriction on the planform. The computation of drag and the statement of the conditions for minimum drag depend on the consideration of a combined flow field, which is obtained by superimposing the disturbance velocities in forward and reversed motions. If the planform of the airfoil and its total lift are given, it is found that, for minimum drag, the lift must be distributed in such a way that the downwash in the combined field is constant over the entire planform. If the planform is given and the thickness of the airfoil is required to contain a specified volume, then the thickness must be distributed over the planform in such a way that the pressure gradient of the combined field in the direction of flight is constant at all points of the wing.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 557-565
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  • 48
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    Calculation of the motion of an airplane under the influence of irregular disturbances (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: The application of mathematical advances made in electricity and other branches to problems of airplane dynamics is demonstrated. The Heaviside-Bromwich methods of solution of linear differential equations are described and it is shown how these methods avoid the consideration of boundary conditions and of particular or complementary integrals. It is pointed out that if the solution of the differential equation is obtained for the case of a unit disturbance, the effect of varying disturbances may be found therefrom by Carson's theorem. A graphical solution of Carson's integral for irregular disturbances is given. The procedure of obtaining unit solutions of the equations is then taken up and the analogy between Heaviside's symbolic series solution and a physical procedure of approximation is shown. It is suggested that a fictitious impulsive disturbance be used in the treatment of initial motions.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 21-29
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  • 49
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    Three-dimensional wings of minimum pressure drag (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: In linearized flow theory, certain very interesting extremal properties of wings can be derived under rather broad conditions without the use of a complicated mathematical apparatus. The present chapter reviews certain results of this theory and indicates some rather obvious extensions to incorporate various auxiliary conditions. Several examples illustrating the relation between the geometrical features of the wing and the lift distribution for minimum drag are given.
    Keywords: AERODYNAMICS
    Type: NASA. Ames Res. Center Collected Works of Robert T. Jones; p 645-656
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  • 50
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    Some recent developments in the aerodynamics of wings for high speeds (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: The items discussed are: (1) a recently proposed correction formula for the effect of compressibility in two dimensional subsonic flow; (2) the equivalence rule and the area rule for transonic speeds; (3) reciprocal relations in linearized wing theory; and (4) some general results connected with the problem of minimum wave resistance. The paper concludes with an example showing indentation of the fuselage to obtain favorable interference with the wing at supersonic speeds.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 601-608
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  • 51
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    Theoretical correction for the lift of elliptic wings (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: In the wing section theory the magnitude of the circulation, and hence of the lift, is determined by the velocity that would be induced near the trailing edge of the section in a non-lifting potential flow. In three dimensional flow the problem is complicated by the presence of the wake and no simple basic solution has been found. Treatment of the problem of a wing of finite span is reported on the basis of the two dimensional theory, corrected for the effect of the wake.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 245-249
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  • 52
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    Reduction of wave drag by antisymmetric arrangement of wings and bodies (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: In theory, antisymmetric arrangements of wings and bodies can have smaller wave drag than corresponding mirror-symmetric arrangements. Thus, a long narrow oblique wing which presents the same aspect for two opposite directions of flight is potentially more efficient than corresponding (i.e., structurally equivalent) swept wing. The single continuous wing panel also adapts itself more readily to varying angles of obliquity, and hence, to varying flight speeds. Previous work on the aerodynamics and flight stability of oblique wing combinations is reviewed and a possible mode of application to transport aircraft operating at moderate supersonic speeds is suggested.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 657-664
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  • 53
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    The compressibility rule for drag of airfoil noses (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: It is shown that the drag of any semi-infinite airfoil section in purely subsonic inviscid flow follows precisely the Prandtl-Glauert compressibility rule. The result for the parabola has application to leading edge corrections in thin airfoil theory.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 619-623
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  • 54
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    Possibilities of efficient high-speed transport airplanes (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: Comparisons of wing-body combinations may not disclose the full effect of a loss in aerodynamic efficiency. If the thrust needs to be increased at a given altitude then more or larger engines will have to be used and the possibility of concealing them becomes less. In this process the lift drag ratio of the complete airplane may become still more unfavorable than indicated by the comparison. Primarily aerodynamic and structural considerations point toward the development of turbojet engines specifically adapted to operation in an atmosphere of one tenth normal density. In addition to the numerous other technological problems associated with operation at these high altitudes, the problems of safe descent and effective limitation to low speeds at low altitudes seem important.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 579-592
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  • 55
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    Leading-edge singularities in thin-airfoil theory (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: If the thin airfoil theory is applied to an airfoil having a rounded leading edge, a certain error will arise in the determination of the pressure distribution around the nose. It is shown that the evaluation of the drag of such a blunt nosed airfoil by the thin airfoil theory requires the addition of a leading edge force, analogous to the leading edge thrust of the lifting airfoil. The method of calculation is illustrated by application to: (1) The Joukowski airfoil in subsonic flow; and (2) the thin elliptic cone in supersonic flow. A general formula for the edge force is provided which is applicable to a variety of wing forms.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 533-538
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  • 56
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    The use of conical and cylindrical fields in supersonic wing theory (1976)
    In:  CASI
    Details
    Publication Date: 2010-11-08
    Description: Some of the recent advances in the theory of thin airfoils are presented with particular reference to extensions of the theory to three dimensional flows and to supersonic speeds. The problem discussed herein is the calculation of the small disturbance velocities u, v, and w in the external field produced by the flight velocity V of the airfoil.
    Keywords: AERODYNAMICS
    Type: Collected Works of Robert T. Jones; p 483-497
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  • 57
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    Transonic/supersonic inlet R and D past, present, and future (1977)
    In:  CASI
    Details
    Publication Date: 2004-10-07
    Keywords: AERODYNAMICS
    Type: NASA Lewis Research Center Inlet Workshop; p 427-480
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  • 58
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    Comments on wind-tunnel-flight correlations for the F-8 supercritical wing configurations (1977)
    In:  CASI
    Details
    Publication Date: 2004-12-03
    Keywords: AERODYNAMICS
    Type: Supercritical Wing Technol.: A Report on Flight Evaluation; p 111-120
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  • 59
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    A parametric experimental study of the slotted-wall boundary condition (1978)
    In:  CASI
    Details
    Publication Date: 2006-02-22
    Description: An experimental study of slotted upper and lower walls in a two dimensional transonic wind tunnel with solid sidewalls is reported. Results are presented for several slot spacings and slot openness ratios. The experimental data were pressure measurements which were made on an airfoil model and on a sidewall near one of the slotted walls. The slotted-wall boundary condition coefficient, which related the pressure and streamline curvature near the wall, was determined from the wall pressure measurements. The measured wall-induced interference was correlated with the experimental values for the boundary condition coefficient. This correlation was compared with theory.
    Keywords: AERODYNAMICS
    Type: Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 459-471
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    In-flight lift and drag measurements on a first generation jet transport equipped with winglets (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A KC-135A aircraft equipped with wing tip winglets was flight tested to demonstrate and validate the potential performance gain of the winglet concept as predicted from analytical and wind tunnel data. Flight data were obtained at cruise conditions for Mach numbers of 0.70, 0.75, and 0.80 at a nominal altitude of 36,000 ft. and winglet configurations of 15 deg cant/-4 deg incidence, 0 deg cant/-4 deg incidence, and baseline. For the Mach numbers tested the data show that the addition of winglets did not affect the lifting characteristics of the wing. However, both winglet configurations showed a drag reduction over the baseline configuration, with the best winglet configuration being the 15 deg cant/-4 deg incidence configuration. This drag reduction due to winglets also increased with increasing lift coefficient. It was also shown that a small difference exists between the 15 deg cant/-4 deg incidence flight and wind tunnel predicted data. This difference was attributed to the pillowing of the winglet skins in flight which would decrease the winglet performance.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 103-116
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  • 61
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    KC-135 winglet program overview (1982)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A joint NASA/USAF program was conducted to accomplish the following objectives: (1) evaluate the benefits that could be achieved from the application of winglets to KC-135 aircraft; and (2) determine the ability of wind tunnel tests and analytical analysis to predict winglet characteristics. The program included wind-tunnel development of a test winglet configuration; analytical predictions of the changes to the aircraft resulting from the application of the test winglet; and finally, flight tests of the developed configuration. Pressure distribution, loads, stability and control, buffet, fuel mileage, and flutter data were obtained to fulfill the objectives of the program.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 1-46
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  • 62
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    KC-135 wing and winglet flight pressure distributions, loads, and wing deflection results with some wind tunnel comparisons (1982)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A full-scale winglet flight test on a KC-135 airplane with an upper winglet was conducted. Data were taken at Mach numbers from 0.70 to 0.82 at altitudes from 34,000 feet to 39,000 feet at stabilized flight conditions for wing/winglet configurations of basic wing tip, 15/-4 deg, 15/-2 deg, and 0/-4 deg winglet cant/incidence. An analysis of selected pressure distribution and data showed that with the basic wing tip, the flight and wind tunnel wing pressure distribution data showed good agreement. With winglets installed, the effects on the wing pressure distribution were mainly near the tip. Also, the flight and wind tunnel winglet pressure distributions had some significant differences primarily due to the oilcanning in flight. However, in general, the agreement was good. For the winglet cant and incidence configuration presented, the incidence had the largest effect on the winglet pressure distributions. The incremental flight wing deflection data showed that the semispan wind tunnel model did a reasonable job of simulating the aeroelastic effects at the wing tip. The flight loads data showed good agreement with predictions at the design point and also substantiated the predicted structural penalty (load increase) of the 15 deg cant/-2 deg incidence winglet configuration.
    Keywords: AERODYNAMICS
    Type: KC-135 Winglet Program Rev.; p 47-102
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  • 63
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    Status of advanced airfoil tests in the Langley 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A joint NASA/U.S. industry program to test advanced technology airfoils in the Langley 0.3-meter Transonic Tunnel (TCT) was formulated under the Langley ACEE Project Office. The objectives include providing U.S. industry an opportunity to compare their most advanced airfoils to the latest NASA designs by means of high Reynolds number tests in the same facility. At the same time, industry would again experience in the design and construction of cryogenic test techniques. The status and details of the test program are presented. Typical aerodynamic results obtained, to date, are presented at chord Reynolds number up to 45 x 10(6) and are compared to results from other facilities and theory. Details of a joint agreement between NASA and the Deutsche Forschungs- und Versuchsantalt fur Luft- and Raumfahrt e.V. (DFVLR) for tests of two airfoils are also included. Results of these tests will be made available as soon as practical.
    Keywords: AERODYNAMICS
    Type: Advan. Aerodyn.: Selected NASA Res.; p 37-53
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  • 64
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    A procedure for analyzing transonic flow over harmonically oscillating airfoils (1978)
    In:  CASI
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    Publication Date: 2006-02-22
    Description: Finite difference procedures were successfully used to solve the steady transonic flow about airfoils and appear to provide a practical means for calculating the corresponding unsteady flow. The purpose of the paper is to describe a finite difference procedure derived from the equations for the potential flow by assuming small perturbations and harmonic motion. The velocity potential is divided into steady and unsteady parts, and the resulting unsteady equation is linearized on the basis of small amplitudes of oscillation. The steady velocity potential, which must be calculated first, is described by the classical nonlinear transonic differential equation.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Res. Center Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 657-670
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  • 65
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    Section drag coefficients from pressure probe transverses of a wing wake at low speeds (1978)
    In:  CASI
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    Publication Date: 2006-02-22
    Description: An in-flight wing wake section drag investigation was conducted using traversing pitot and static probes. The primary objective was to develop measurement techniques and improve the accuracy of in-flight wing profile drag measurements for low values of dynamic pressure and Reynolds number. Data were obtained on a sailplane for speeds from about 40 knots to 125 knots at chord Reynolds numbers between 1,000,000 and 3,000,000. Tests were conducted with zero flap deflection, deflected flaps, and various degrees of surface roughness, and for smooth and rough atmospheric conditions. Several techniques were used to increase data reliability and to minimize certain bias errors. A discussion of the effects of a total pressure probe in a pressure gradient, and the effects of discrete turbulence levels, on the data presented and other experimental results is also included.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Res. Center Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 601-621
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  • 66
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    Some calculations of transonic potential flow for the NACA 64A006 airfoil with oscillating flap (1978)
    In:  CASI
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    Publication Date: 2006-02-22
    Description: A method for calculating the transonic flow over steady and oscillating airfoils was developed by Isogai. It solves the full potential equation with a semi-implicit, time-marching, finite difference technique. Steady flow solutions are obtained from time asymptotic solutions for a steady airfoil. Corresponding oscillatory solutions are obtained by initiating an oscillation and marching in time for several cycles until a converged periodic solution is achieved. In this paper the method is described in general terms, and results are compared with experimental data for both steady flow and for oscillations at several values of reduced frequency. Good agreement for static pressures is shown for subcritical speeds, with increasing deviation as Mach number is increased into the supercritical speed range. Fair agreement with experiment was obtained at high reduced frequencies with larger deviations at low reduced frequencies.
    Keywords: AERODYNAMICS
    Type: Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 689-700
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  • 67
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    Applications of dynamic measurement techniques to wind-tunnel testing (1978)
    In:  CASI
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    Publication Date: 2006-02-22
    Description: The uses of laser Doppler velocimeter, hot wire, and surface hot film techniques in the study of turbulent flows are described, and data obtained in compressible flows are discussed. Applications are illustrated with measurements of wind tunnel freestream turbulence characteristics and with data obtained in transitional, turbulent, and separated shear flows. A new method which was developed for the study of time dependent and unsteady turbulent flows is also presented.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Res. Center Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 571-588
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  • 68
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    Component testing for dynamic model verification (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Dynamic model verification is the process whereby an analytical model of a dynamic system is compared with experimental data, adjusted if necessary to bring it into agreement with the data, and then qualified for future use in predicting system response in a different dynamic environment. These are various ways to conduct model verification. The approach taken here employs Bayesian statistical parameter estimation. Unlike curve fitting, whose objective is to minimize the difference between some analytical function and a given quantity of test data (or curve), Bayesian estimation attempts also to minimize the difference between the parameter values of that funciton (the model) and their initial estimates, in a least squares sense. The objectives of dynamic model verification, therefore, are to produce a model which: (1) is in agreement with test data; (2) will assist in the interpretation of test data; (3) can be used to help verify a design; (4) will reliably predict performance; and (5) in the case of space structures, will facilitate dynamic control.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 15 p
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  • 69
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    Post and a random-walk search mode (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Multidisciplinary analysis often requires optimization of nonlinear systems that are subject to constraints. Trajectory optimization is one example of this situation. The Program to Optimize Simulated Trajectories (POST) was used successfully for a number of problems. The purpose is to describe POST and a new optimization approach that has been incorporated into it. Typical uses of POST will also be illustrated. The projected-gradient approach to optimization is the preferred option in POST and is discussed. A new approach to optimization, the random-walk approach, is described, and results with the random-walk approach are presented.
    Keywords: AERODYNAMICS
    Type: Recent Experiences in Multidisciplinary Analysis and Optimization, Part 2; 23 p
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  • 70
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    Wall interference measurements for three-dimensional models in transonic wind tunnels: Experimental difficulties (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The purpose is not to provide a detailed discussion of several wall interference experiments, but rather to use these experiments (recently accomplished in the Boeing Transonic Wind Tunnel (BTWT) to illustrate the problems associated with many of the measurements required by current wall interference assessment/correction (WIAC) procedures. The wall correction to lift is emphasized. It is shown that, because conventional tunnels and relatively small models continue to be used, the flow field or flow boundary measurements to be made impose severe requirements on the experiment itself. In some cases, existing instrumentation and test techniques may not be adequate to obtain the data accuracies needed.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 21-42
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  • 71
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    Adaptation of a four-wall interference assessment/correction procedure for airfoil tests in the 0.3-m TCT (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Based upon limited, initial observations of wall interference corrections obtained for one airfoil test, there is a need for assessing the upstream flow direction. If there is no direct measurement then a two-pass correction procedure similar to the one described here is required. Questions have arisen pertaining to the correct interpretation of the pressure coefficients measured on the slats of a slotted tunnel wall, the interpretation of just what the calculated equivalent body encompasses or should include, and what can or should be considered as quantitative criteria for data correctability. Further studies using this modified procedure will address these questions. Hopefully, a meaningful WIAC procedure can be validated for the airfoil tests in the 0.3-m TCT.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 393-414
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  • 72
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    Some experience with Barnwell-Sewall type correction to two-dimensional airfoil data (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A series of airfoils were tested in the Langley 0.3-Meter Transonic Cryogenic Tunnel (TCT) at Reynolds numbers from 2 to 50 million. The 0.3-m TCT is equipped with Barnwell slots designed to minimize blockage due to the tunnel flow and ceiling. This design suggests that sidewall corrections for blockage is needed, and that a lifting airfoil produces a change in angle of attack. Sidewall correction methods were developed for subsonic and subsonic-transonic flow. Comparisons of theory with experimental data obtained in the 0.3-m TCT for two airfoils, the British NPL 9510 and the German R-4 are presented. The NPL 9510 was tested as part of the NASA/United Kingdom Joint Aeronautical Program and R-4 was tested as part f the DFVLR/NASA Advanced Airfoil Research Program. For the NPL 9510 airfoil, only those test points that one would anticipate being difficult to predict theoretically are presented.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 375-392
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  • 73
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    Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 345-360
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  • 74
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    An inerference assessment approach for a three-dimensional slotted tunnel with sparse wall pressure data (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The various procedures referred to as wall interference assessment and correction procedures presume the existence of a surface distribution of data (usually static pressure) measured over a surface on or near the tunnel walls for each test point to be assessed. An alternative approach in which a reasonably sophisticated computer model of the test section flow would be fitted parametrically to a sparse set of measured data is presented. The measurements provides line distributions of static pressure near the center lines of the top, side and bottom walls. The development of a test section model incorporating explicit recognition of discrete slots of finite length with controlled flow reentry into the solid wall downstream portion of the tunnel is shown.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 323-334
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  • 75
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    Aircraft (1977)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: The physical principles of flight, and the consideration of atmospheric composition and aerodynamic forces in the design and construction of various types of aircraft are discussed. Flight characteristics are described for helicopters, rotary-wing aircraft, short and vertical takeoff aircraft, and tailess or variable geometry wing aircraft. Flow characteristics at various speeds are also discussed.
    Keywords: AERODYNAMICS
    Type: Soviet Aircraft and Rockets (NASA-TT-F-770); p 24-80
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  • 76
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    Executive summary of Aircraft Icing Specialists Workshop (1979)
    In:  CASI
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    Publication Date: 2006-01-12
    Description: In a period of escalating development costs for new aircraft, there is growing interest in a renewed and coordinated icing research effort to achieve an updating or modernization of each aspect of the technological issues that are involved. This includes the data base, analysis methods, test techniques, and test facilities.
    Keywords: AERODYNAMICS
    Type: Aircraft Icing; p 1-16
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  • 77
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    Safety hazard of aircraft icing (1979)
    In:  CASI
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    Publication Date: 2006-01-12
    Description: The problem of aircraft icing is reported as well as the type of aircraft affected, the pilots involved, and an identification of the areas where reduction in icing accidents are readily accomplished.
    Keywords: AERODYNAMICS
    Type: NASA. Lewis Res. Center Aircraft Icing; p 21-27
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  • 78
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    The lateral flying qualities of the Bell XP-77 airplane as estimated from full-scale tunnel tests, 16 June 1944 (1976)
    In:  CASI
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    Publication Date: 2006-01-16
    Description: Results are presented for tests made of the full scale model of the airplane in the NACA full scale tunnel. These tests were planned so as to cover as completely as possible the lateral flying quality requirements for pursuit-type airplanes contracted for by the United States Army Air Forces.
    Keywords: AERODYNAMICS
    Type: Collected Works of Charles J. Donlan; 23 p
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  • 79
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    Civil Helicopter icing problems (1979)
    In:  CASI
    Details
    Publication Date: 2006-01-12
    Description: The ice capabilities of rotary wing aircraft are examined. Recommendations are given to improve the inadequacies of the weather forecasts pertaining to ice, and to adopt a low maintenance anti-ice system.
    Keywords: AERODYNAMICS
    Type: NASA. Lewis Res. Center Aircraft Icing; p 29-30
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  • 80
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    Overview of helicopter ice protection system developments (1979)
    In:  CASI
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    Publication Date: 2006-01-12
    Description: Helicopter ice protection design criteria was developed and technological shortcoming in meeting helicopter mission requirements is that of helicopter rotor blade ice protection. Airframe components are protected using existing technology while the rotor blade protected using the cyclic electrothermal deicing concept.
    Keywords: AERODYNAMICS
    Type: NASA. Lewis Res. Center Aircraft Icing; p 39-65
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  • 81
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    A review of the icing situation from the standpoint of general aviation (1979)
    In:  CASI
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    Publication Date: 2006-01-12
    Description: An overview of the present situation in the field of aircraft icing with respect to certification and operation of nontransport category airplanes is given. Problems of definition and inconsistencies are pointed out. Problems in the forecasting and measurement of icing intensities are discussed. The present regulatory environment is examined with respect to its applicability and appropriateness to nontransport airplanes.
    Keywords: AERODYNAMICS
    Type: NASA. Lewis Res. Center Aircraft Icing; p 31-38
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  • 82
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    Icing of aircraft Some remarks with an historical slant from a cloud physicist (1979)
    In:  CASI
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    Publication Date: 2006-01-12
    Description: Three areas of interest are commented on: cloud physics, nowcasting, and instrumentation. A comparison is made of what was done 30 years ago to what might be done in light of developments in related areas of cloud physics, weather modification and instrumentation.
    Keywords: AERODYNAMICS
    Type: NASA. Lewis Res. Center Aircraft Icing; p 17-19
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  • 83
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    Computational aerodynamics (1975)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: The application of computer techniques for solving Navier-Stokes equations in support of wind tunnel tests is discussed. The ILLIAC IV computer is considered for this purpose and its limitations are analyzed. The author states that improved computers will make it possible to solve many aerodynamic problems and reduce the amount of wind tunnel testing required for adequate data processing.
    Keywords: AERODYNAMICS
    Type: NASA/Univ. Conf. on Aeron.; p 211-212
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  • 84
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    On wake vortex alleviation (1975)
    In:  CASI
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    Publication Date: 2006-01-11
    Description: Research within NASA relating to the nature of lift-induced vortex wakes behind large aircraft and the means whereby the hazard they represent to smaller aircraft can be alleviated is reviewed. The research, carried out in ground based facilities and in flight shows that more rapid dispersion of the wake can be effected by several means and that the modification of span-loading by appropriate flap deflection holds promise of early practical application.
    Keywords: AERODYNAMICS
    Type: NASA/Univ. Conf. on Aeron.; p 143-168
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  • 85
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    Interference from slotted walls (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Wall interference is made predominant in tunnel models and by wall geometries to facilitate the study of slot flow. The viscous effects in slots are studied by two dimensional measurements of flow. Wall interference is assessed by measuring pressure distributions at two levels near the walls. Interference on lifting delta wings is calculated. Pressure distributions at inner boundaries show basis axisymetries between the pressure side and the suction side, pointing to the necessity of having wider slots on the pressure side.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 293-300
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  • 86
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    Development in UK of a method for calculating tunnel wall corrections from flow measurements (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Classical methods for calculation of wall corrections which are not satisfactory for a number of flows of interest are discussed. To meet these objections, a number of methods were developed which use measurements of the low at or close to the tunnel walls as an outer boundary condition to define wall interference. The development, assessment and application of one such method is summarized.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 259-271
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  • 87
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    NLR activities in the field of wind tunnel wall interference (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Measured field data as a boundary condition for calculating the interference flow field were applied. They are divided into two categories. In the first category, the field data must consist of distributions of a single velocity component, and an accurate estimate of the hypothetical free air contribution of the model to this component is required. The differences between measured values and estimated model contributions are attributed to wall interference and they establish the boundary condition. The associated field data measurements are simple, yet the necessary model representation generally is a serious drawback. The second category requires field data which consist of velocity vector distributions at the price of multicomponent measurements, but at the profit that no information at all is required about the model. In solid wall test sections, the price is reduced to virtually zero but the profit remains.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 221-229
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  • 88
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    Performance of two transonic airfoil wind tunnels utilizing limited ventilation (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A limited-zone ventilated wall panel was developed for a closed-wall icing tunnel which permitted correct simulation of transonic flow over model rotor airfoil sections with and without ice accretions. Candidate porous panels were tested in the Ohio State University 6- x 12-inch transonic airfoil tunnel and result in essentially interference-free flow, as evidenced by pressure distributions over a NACA 0012 airfoil for Mach numbers up to 0.75. Application to the NRC 12- x 12-inch icing tunnel showed a similar result, which allowed proper transonic flow simulation in that tunnel over its full speed range.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 165-170
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  • 89
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    Investigations of flow field perturbations induced on slotted transonic-tunnel walls (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The free-stream interference caused by the flow through the slotted walls of the test sections of transonic wind tunnels has continuously a problem in transonic tunnel testing. The adaptive-wall transonic tunnel is designed to actively control the near-wall boundary conditions by sucking or blowing through the wall. In order to make the adaptive-wall concept work, parameters for computational boundary conditions must be known. These parameters must be measured with sufficient accuracy to allow numerical convergence of the flow field computations and must be measured in an inviscid region away from the model that is placed inside the wind tunnel. The near-wall flow field was mapped in detail using a five-port cone probe that was traversed in a plane transverse to the free-stream flow. The initial experiments were made using a single slot and recent measurements used multiple slots, all with the tunnel empty. The projection of the flow field velocity vectors on the transverse plane revealed the presence of a vortex-like flow with vorticity in the free stream. The current research involves the measurement of the flow field above a multislotted system with segmented plenums behind it, in which the flow is controlled through several plenums simultaneously. This system would be used to control a three-dimensional flow field.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 119-142
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  • 90
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    Assessment of lift- and blockage-induced wall interference in a three-dimensional adaptive-wall tunnel (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A three-dimensional adaptive-wall wind tunnel experiment was conducted at Ames Research Center. This experiment demonstrated the effects of wall interference on the upwash distribution on an imaginary surface surrounding a lifting wing. This presentation demonstrates how the interference assessment procedure used in the adaptive-wall experiments to determine the wall adjustments can be used to separately assess lift- and blockage-induced wall interference in a passive-wall wind tunnel. The effects of lift interference on the upwash distribution and on the model lift coefficient are interpreted by a simple horseshoe vortex analysis.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 89-100
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    Wind tunnel wall interference in closed, ventilated and adaptive test sections (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A wall interference correction method for closed rectangular test sections was developed which uses measured wall pressures. Measurements with circular discs for blockage and a rectangular wing as a lift generator in a square closed test section validate this method. These measurements are intended to be a basis of comparison for measurements in the same tunnel using ventilated (in these case, slotted) walls. Using the vortex lattice method and homogeneous boundary conditions, calculations were performed which show sufficiently high pressure levels at the walls for correction purposes in test sections with porous walls. In Gottingen, an adaptive test section (which is a deformable rubber tube of 800 mm diameter) was built and a computer program was developed which is able to find the necessary wall adaptation for interference-free measurements in a single step. To check the program prior to the first run, the vortex lattice method was used to calculate wall pressure distributions in the nonadapted test section as input data for the one-step method. Comparison of the pressure distribution in the adapted test section with free-flight data shows nearly perfect agreement. An extension of the computer program can be made to evaluate the remaining interference corrections.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 61-78
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  • 92
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    Review of the advanced technology airfoil test program in the 0.3-meter transonic cryogenic tunnel (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The following areas were addressed: interchangeable test sections in the 0.3-M Transonic Cryogenic Tunnel (TCT); typical airfoil installation; airfoil capability; advanced technology airfoil test (ATAT); effects of the Reynolds number on the normal force coefficient; effects of the Reynolds number on the drag coefficient; and comparison of experimental results with theory.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 361-374
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  • 93
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    Determination of equivalent model geometry for tunnel wall interference assessment/correction (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A formula for the determination of equivalent model geometry with two variables measured at the interface is derived, based on two dimensional subsonic flow. This predicted model profile is a reasonable initial estimate for transonic flow as long as the sonic region does not reach the interface. A general formula is given in two forms. One is in terms of complex variable functions and the other is an integral equation. The complex-function formula has the advantage of using analytic expressions. The integral equation form requires a numerical solution after assuming the model geometry as a polynomial function. Examples are given to illustrate the application of the formulas.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 335-342
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  • 94
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    An analytic solution to the classical two-body problem with drag (1981)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The two body problem was analyzed with a specific drag model. The model treats drag as a force proportional to the vector velocity and inversely proportional to the distance to the center of attraction. The solution is expressed in terms of known functions and is of a simple and compact form. The time of flight is expressed as a quadrature in the true anomaly. The results are: (1) development of a vector differential equation which allows analysis of an infinite number of gravitational and drag models; and (2) obtaining the solution of a linear differential equation using the inverse method of laplace transforms.
    Keywords: AERODYNAMICS
    Type: Houston Univ. The 1981 NASA ASEE Summer Fac. Fellowship Program, Vol. 2; 22 p
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  • 95
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    Wind tunnel wall interference correction for aircraft models (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Wall interference correction procedures seek to determine the required changes in certain flow or geometric parameters so that the difference between the flow properties at the model's surface in the tunnel and free air are minimized. A transonic and a linear correction procedure were developed for aircraft models. In addition to Mach number and angle of attack corrections, an estimate of the accuracy of the corrections is provided by the transonic correction procedure. Lift, pitching moment and pressure measurements near the tunnel walls are required. The efficiency and accuracy of the correction procedure are improved. Moreover, correction of both the wing and tail angles of attack is allowed. The procedure is valid for transonic as well as subcritical flows. However, for subcritical flows further approximations and simplifying assumptions are made, leading to a very simple and efficient correction procedure.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 301-322
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  • 96
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    Tunnel constraint for a jet in crossflow (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: A facet of a unified tunnel correction scheme which uses wall pressures to determine tunnel induced blockage and upwash is described. With this method, there is usually no need to use data concerning model forces or power settings to find the interference; it follows directly from the pressures and tunnel dimensions. However, highly inclined jets do not produce good pressure signatures and are highly three dimensional, so they must be treated differently. Flow modeling is also discussed.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center. Wind Tunnel Wall Interference Assessment and Correction, 1983; p 273-290
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    Progress in wind tunnel wall interference assessment/correction procedures at the NAE (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: Wall corrections as a function of wall porosity in the transonic wall interference problem was assessed. Effective porosities primarily for the two dimensional case were established as follows: (1) comparison of experimental data for two geometrically similar models of different chord/height ratio, an overall value of wall porosity could be deduced; (2) theoretical development which allows for unequal porosity for the floor and ceiling and wall boundary pressure measurements, porosities for floor and ceiling could be deduced; (3) a scheme was developed which allowed unequal porosity of floor and ceiling and streamwise varying porosity. The boundary layer development along the perforated floor and ceiling under the influence of the model pressure field, variations in boundary layer thickness underlining the difficulties in deducing meaningful values of wall porosity were determined. Wall boundary pressure measurement, in combination with singularity modelling of the airfoil, was sufficient to yield required information on the wall interference flow without having to establish some value for wall porosity. The singularity modelling of the airfoil initially covered only lift and volume but was extended to include drag and pitching moment, and second order volume term. It is shown by asymptotic transonic small disturbance analysis, that the derived corrections to angle of attack and free stream Mach number are correct to the first order.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 231-257
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  • 98
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    Asymptotic methods for wind tunnel wall corrections at transonic speed (1984)
    In:  CASI
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    Publication Date: 2006-02-14
    Description: The effort to develop classical methods to compute wall interference at transonic speeds is outlined. The two-dimensional theory and three-dimensional development are discussed. Also, some numerical application of the two-dimensional work are indicated. The basic advantages of the asymptotic theory are noted.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 193-203
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  • 99
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    Effect of boundary layers on solid walls in three-dimensional subsonic wind tunnels (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: A solution for the tunnel wall boundary layer effects for three-dimensional subsonic tunnels is presented. The model potentials are represented with simple singularities placed on the centerline of the tunnel and Laplace's equation in cylindrical coordinates is solved for either the conventional homogeneous slotted-wall boundary condition, the solid-wall viscous boundary condition, or a combination of them. The most pronounced wall boundary layer effect is on solid blockage for completely closed wind tunnels. Boundary layers on the wall reduce the blockage from the solid-wall, no-boundary-layer case in a manner similar to opening slots in a solid wall. Additionally, for solid-wall tunnel configurations, the streamline curvature interference factor is reduced by a significant amount, whereas the lift interference factor at the model station does not depend on the boundary layer parameter. For combination wall configurations, the slot effect of the horizontal walls dominates the viscous effect of the solid sidewalls.
    Keywords: AERODYNAMICS
    Type: Wind Tunnel Wall Interference Assessment and Correction, 1983; p 205-218
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    Experiments suitable for wind tunnel wall interference assessment/correction (1984)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Three experiments suitable for wall interference assessment and evaluation of proposed correction methods are presented. The experiments are: (1) a series of airfoil tests using a newly designed transonic flow facility that employs side-wall boundary layer suction and upper- and lower-wall shaping; (2) tests on a swept airfoil section spanning a solid-wall wind tunnel with fixed contouring on all four walls; and (3) tests on a swept wing of aspect ratio 3 mounted in a solid-wall wind tunnel with fixed flat walls. Each of the experiments provides data on the airfoil sections as well as on the wind tunnel walls. All the experiments were performed in solid wall wind tunnels corrected for boundary layer displacement effects. Although the experiments were performed primarily to evaluate computer code performance, it is believed that they also provide information that can be used to evaluate methods for assessing and correcting wall interference effects.
    Keywords: AERODYNAMICS
    Type: NASA. Langley Research Center Wind Tunnel Wall Interference Assessment and Correction, 1983; p 171-190
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