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  • Articles  (30,572)
  • American Association for the Advancement of Science (AAAS)  (24,129)
  • Blackwell Publishing Ltd  (4,119)
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  • Articles  (30,572)
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  • 1
    Electronic Resource
    Electronic Resource
    Introducing new computer-based systems into Zenbank (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the author examines the development and implementation of a computer-based system within a financial services organization. It highlights emerging paradoxes within the developments of systems design which utilise quality management methodologies to support IT intensive business processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1994.tb00055.x
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  • 2
    Electronic Resource
    Electronic Resource
    Power and EDP departments: a case study (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The productivity of white-collar workers in heavily computerized sectors of the economy has collapsed in recent years. This paper suggests that one reason for this involves inefficiencies generated by EDP departments, which have created systems of control enmeshing not only workers but senior management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00042.x
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  • 3
    Electronic Resource
    Electronic Resource
    The involvement of trade unions in quality: evidence from EC enterprises (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: In 1987–88 a large attitudinal survey covering all 12 Member States of the European Community was carried out by the European Foundation for the Improvement of Living and Working Conditions in Dublin which focused on various aspects of participation by employee representatives in new information technology. This paper presents evidence on one important aspect of technological change—that of participation in product and service quality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00043.x
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  • 4
    Electronic Resource
    Electronic Resource
    The employment effects of new technology and organizational change: an empirical study (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Studies of the relationship between technological change and employment are placed in a conceptual framework prior to an empirical study of the direct employment effects of new technology and a comparison with the effects of organizational change. It shows that the latter are considerably greater than the former, though both are relatively minor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00044.x
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  • 5
    Electronic Resource
    Electronic Resource
    Construction robotics: technological change and work organization (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Attempts to develop robots for use on construction sites are following different paths in Britain and Japan. Japanese construction firms have invested heavily in modification of existing equipment to improve productivity and quality by making good use of machine operators' skills. In contrast, British researchers are attempting to make ‘quantum leaps' in construction technologies by developing automated machinery which requires minimal human intervention and operator skills. The article assesses the viability of these two contrasting approaches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00029.x
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  • 6
    Electronic Resource
    Electronic Resource
    Information technology, organizational restructuring and the future of middle management (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article examines the impact of information technology as one of the factors affecting the numbers and roles of middle managers. The authors highlight the need to empirically examine middle management work in the context of the complexity of changes affecting the job of middle managers and the complexity of reactions to these changes, if further assertions about the future of middle management are to be avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00030.x
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  • 7
    Electronic Resource
    Electronic Resource
    Book Reviews (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviews in this article:Technology and Organization: power, meaning and design Harry Scarbrough and J. Martin CorbettRoads to Participation in the European Community—Increasing prospects of employee representatives in technological change Dieter Fröhlich, Colin Gill and Hubert KriegerAdvanced Technology in Commerce, Offices and Health Services Fe Josefina Dy (Ed.)Industrial Dislocation: The case of global shipbuilding Daniel ToddCompany and Campus Partnership: Supporting Technology Transfer D. Jane BowerHigh-Tech Fantasies: Science Parks in Society, Science and Space Doreen Massey, Paul Quintas and David WieldTechnological Change: The Role of Scientists and Engineers Derek Bosworth, Rob Wilson and Paul TaylorFarewell to Flexibility Anna Pollert (ed.)Industrial Training in a Cold Climate Peter J. SenkerManaging New Technological Change: Case Studies in the Reorganization of Work P. WilkinsOther Publications Received Dodgson, M.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00045.x
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  • 8
    Electronic Resource
    Electronic Resource
    Workplace implications of FMS and CIM in Denmark and Sweden (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Drawing on experiences from the introduction of FMS and CIM in Denmark and Sweden this article deals with the impact on social relations between management and employees and the new challenges faced by the unions. The authors call for a stronger profile in union policy concerning technology and work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00031.x
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  • 9
    Electronic Resource
    Electronic Resource
    Production restructuring in the textiles and clothing industries (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article analyses the processes of restructuring in the textiles and clothing industries in a locality. Particular attention here is focused on new technology, labour flexibility, sub-contracting patterns and skill factors. The extent to which the process of restructuring involves a conscious and deliberate move to new patterns of work organization is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00033.x
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  • 10
    Electronic Resource
    Electronic Resource
    Taylorism, new technology and just-in-time systems in Japanese manufacturing (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article attempts to examine what is believed to be a significant overall Taylorist influence in Japanese manufacturing as well as a specific manifestation of this phenomenon, namely the unique flow requirements of the generic Toyota system (JIT). The use of unbufferred flow, it is argued, is feasible only with consistent quality, thus making non-discretionary Taylorist job design a necessary condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00032.x
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  • 11
    Electronic Resource
    Electronic Resource
    Industrial relations in UK clearing banks: a comment on Cressey and Scott (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the author explores the manifestations of discontent resulting from conflictual industrial relations in banking. This has brought about changes, it is argued, that are of equal significance to those referred to by Cressey and Scott.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00035.x
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  • 12
    Electronic Resource
    Electronic Resource
    From coal mining to a high technology economy? the case of an innovation centre in South Yorkshire (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The deep coal mining industry was in rapid decline in Britain in the 1980s and 1990s. In many localities formerly associated with the industry, there was a need to encourage diversification and innovation as a means of economic regeneration. The activities of one project which aimed at this are examined here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00034.x
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  • 13
    Electronic Resource
    Electronic Resource
    Careers and industrial action in banking: reply to a comment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00036.x
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  • 14
    Electronic Resource
    Electronic Resource
    Book Reviews (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviews in this article:Design at Work: Cooperative Design of Computer Systems Joan Greenbaum and Morten Kyng (Eds.)Flexible Manufacturing Technologies and International Competitiveness Joseph TiddCase Studies in Information Technology, People and Organizations Karen LeggeReshaping Work: The Cadbury Experience Chris Smith, John Child and Mike Rowlinson
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1993.tb00037.x
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  • 15
    Electronic Resource
    Electronic Resource
    Employment, technology and industrial relations in the UK clearing banks: is the honeymoon over? (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Employment in UK retail banking has begun to decline as all the major institutions shed workers. Technological, organizational and market-driven reasons for the job losses in the major clearing banks are discussed. Irrevocable long-term changes in employers' industrial relations and human resource strategies are identified as necessary accompaniments to pushing the current retrenchment through in the context of a developing general crisis in employment relations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00023.x
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  • 16
    Electronic Resource
    Electronic Resource
    Pushing back the frontiers: management control and work intensification under JIT/TQM factory regimes (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Drawing on primary and secondary sources the authors argue that the JIT/TQM manufacturing system intensifies work as a result of increased surveillance and monitoring of workers' activities, heightened responsibility and accountability, the harnessing of peer pressure within ‘teams' and via ‘customers', and the fostering of ‘involvement’ in waste elimination and the continuous improvement of the production process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00024.x
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  • 17
    Electronic Resource
    Electronic Resource
    Subcontracting in banking: some evidence from Britain and France (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The oversimplified analysis of subcontracting in terms of the relations between small and large firms needs to be abandoned in favour of a broader societal approach. Drawing on empirical evidence from Britain and France it is argued that such an approach can identify a wider range of political, social and economic factors affecting the decision to subcontract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00025.x
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  • 18
    Electronic Resource
    Electronic Resource
    CNC technology, job design and training: the scope for personnel strategies (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Drawing on empirical material from a research project on new technology and skills, the author discusses the scope for personnel strategies within a context of varying social constraints. He concludes that within a given production and at a given level of technology, a variation of strategies for staff training and development may emerge. It is argued that the style of management plays a considerable role in determining job design and skill development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00026.x
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  • 19
    Electronic Resource
    Electronic Resource
    Local perspectives on new process technology and employment (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article examines the introduction of new process technology into a local labour market in the late 1980s and relates variations in adoption rates to establishment characteristics. The authors highlight the contrasts in the employment outcomes and training requirements in adopting and non-adopting establishments and find that ‘adopters' expect more changes in employment, more skills shortages and have a greater awareness of future training needs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00027.x
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  • 20
    Electronic Resource
    Electronic Resource
    Book Reviews (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviews in this article:Poor Work: Disadvantage and the Division of Labour Phillip Brown and Richard Scase (eds.)Critical Theory of Technology Andrew FeenbergBuilding Capitalism: Historical Change & the Labour Process in the Production of the Built Environment Linda ClarkeRestructuring a Traditional Industry: Construction Employment and Skills in Europe Helen Rainbird and Gerd Syben (eds.)Science Policy Research: Implications and Applications Darcy F. De Almeida (ed.)Connections: New Ways of Working in the Networked Organisation L. Sproull and S. KieslerOrganizational Structure and Information Technology Jon HarringtonManufacturing Knowledge: A History of the Hawthorne Experiments Richard Gillespie
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00028.x
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  • 21
    Electronic Resource
    Electronic Resource
    Work practice barriers to flexible manufacturing in the US and the UK (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Work practice barriers to flexible manufacturing are studied in the British and American unionized engineering industries and a comparison made of the influence of the industrial relations systems on the potential for overcoming these barriers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00016.x
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  • 22
    Electronic Resource
    Electronic Resource
    Where are they now? Some changes in firms located on UK Science Parks in 1986 (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article looks at changes in the performance and operation of a group of high technology firms over a four year period, in particular comparing their record of employment creation with that of small new firms as a whole; examining the existence of the often discussed ‘soft-hard transition’ in products; and the importance of ownership change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00017.x
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  • 23
    Electronic Resource
    Electronic Resource
    Work organization and occupational development in CIM: the case of Swedish NC machine shops (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article reports the results of a large survey of Swedish manufacturing companies employing numerically-controlled technology, on work organization and the changing nature of operator skills. The results are assessed in the light of likely changes in organizational structures and skill composition in future forms of computer-integrated manufacturing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00018.x
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  • 24
    Electronic Resource
    Electronic Resource
    Police management, office automation and organizational change (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Police forces, in common with much of the UK system of public administration, continue to come under pressure to engage in managerial and administrative modernisation. This article looks at the role office automation systems play in these processes and at the case for organizational change to accompany the adoption of these systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00019.x
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  • 25
    Electronic Resource
    Electronic Resource
    Bank computerization and organizational innovations: the long winding road to the bank of the future (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Despite increasing customer orientation and a more proactive IT policy in the services offered by Dutch banks, organizational innovation has been partial and segmented. Changes in organizational structure are complicated by the current wave of mergers between banks and insurance companies.[1]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00020.x
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  • 26
    Electronic Resource
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    Enterprise size, information technology and the service sector—the employment implications (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Using data gained from a study of the insurance and accounting industries, this article demonstrates the importance of the relationship between enterprise size and enterprise susceptibility to the employment effects of information technology in the service sector.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00021.x
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  • 27
    Electronic Resource
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    Book Reviews (1992)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 7 (1992), S. 0 
    Details
    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Managing Innovation: a Study of British and Japanese Factories D. H. Whittaker Systems that Support Decision Makers: Description and Analysis Mark S. Silver Modern Organisations; Organisation Studies in the Postmodern World Stewart Clegg Office Automation: Context, Experience and Future Andrew Doswell The Quest for Productivity Bruce W. Ahlstrand Feminism Confronts Technology Judy Wajcman
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1992.tb00022.x
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  • 28
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    The art of building a car: the Swedish experience re-examined (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The Swedish automobile industry has recently encountered significant difficulties. This article reviews a major study of the relationships between production, technology and work organisation in Volvo and Saab. It compares the Swedish approach to automobile production with those of the American and Japanese companies and speculates on whether the Swedish industry will survive in the coming decade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00134.x
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  • 29
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    Changing technology and design work in the British engineering industry, 1981–1988 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Technologies and management strategies change over time and interact. Longitudinal studies can shed some light on this process, and can also contribute to understanding of how relationships between technology and working conditions change over time.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00135.x
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  • 30
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    The challenge of CAD/CAM: some experiences of British and Canadian engineering companies (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article considers factors which influence the readiness of management to associate organisational with technological change. Outcomes are related to the socio-political environment of firms and the position of engineers in the two countries.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00136.x
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  • 31
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    Restructuring, productivity and workplace relations: evidence from the textile industry (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This study analyses the nature of productivity improvements in the textile industry by focusing on the interplay between micro-electronic technologies and changes in work practices at two hosiery plants and a cotton spinning mill. The findings highlight the uneven impact of technological change on workplace relations and patterns of occupational segregation.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00138.x
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  • 32
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    New technologies and working time: The case of CAD introduction (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The introduction of new technology is often accompanied by changes in working time arrangements. These changes, however, are by no means homogeneous. They are contingent upon a variety of factors which may differ widely from organization to organization. Using findings from a study on the consequences of CAD application it is shown that among these factors the bargaining power of affected employee groups is particularly important.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00137.x
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  • 33
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    Skill changes in maintenance work in British Telecom: an alternative view (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the author presents an alternative view of recent changes in skilled work in British Telecom to that provided by Roger Penn in a recent article in NTWE. In particular, he argues for a detailed analysis of changing work tasks, a clear definition of skill, and a greater focus on the changing distribution of tasks and skills between different occupational groups.
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    Book Reviews (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviewed in this articleTechnology and the Labour ProcessUnder New Management: Australian Organisations in TransitionTechnological Development and the Improvement of Living and Working Conditions: Options for the FutureInformation Technology in European Services: Towards a Microelectronic FutureSkills, Wages and Productivity in the Service SectorThe Spatial Context of Technological DevelopmentThe Technical Challenges and Opportunities of a United EuropeTechnology and the Pursuit of Economic GrowthNew Explorations in the Economics of Technological ChangeR&D Management: Managing Products and New Processes (2nd edition)The Employment Impact of New TechnologyThe Strategic Management of Technological InnovationNew Firms in the Biotechnology Industry: Their Contribution to Innovation and Growth
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    Developing Japan's R & D staff: in search of a new personnel management? (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The traditional system of managing corporate manpower resources in Japan has fostered incremental innovation, diversification and organic growth. The establishment of R & D labs for frontier research has brought debate about the need to reform, or even abandon, traditional methods. The evidence to date suggests marginal rather than wholesale change.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1991.tb00127.x
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    The dynamics of just-in-time (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article analyses the impact of just-in-time production on the three resources of machines, materials and people, and suggests that JIT entails a redistribution of slack between these resources. The impact of JIT on an organization's human resources is particularly problematical; pressures towards both increased variety and intensity of work are apparent.
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    Organizational factors and technology-intensive industry: the US and Japan (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: High technology industry in the US and Japan can be thought of as distinct organizational models. Here the authors examine the historical evolution, major characteristics, and benefits and costs of these different models. This leads to the conclusion that organizational factors exert a powerful influence on the ability of firms, industries and nations to adapt to new technology-intensive industries.
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    Book Reviews (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviewed in this articleInnovation in Technology and OrganizationUnpacking the Clothing Industry: Gender, Racism and Class in ProductionComputer Systems Development: history, organisation and implementationEnvisioning A Sustainable Society: Learning Our Way OutComputers, Jobs and Skills: The Industrial Relations of Technological ChangeDeveloping Skills with Information TechnologyMaintaining Information Systems in OrganisationsHostile Brothers: Competition and Closure in the European Electronics Industry
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    A research note: information technology and company performance in the textile industry (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the authors examine the role of computer networks on organisations engaged in textile and clothing manufacture. The results reveal that companies with a computer network performed significantly better than those without, both in terms of growth in employment and return on sales over the period 1985–87
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    New technology and the restructuring of pit-level industrial relations in the British coal industry (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    ISSN: 1468-005X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Since the 1984–85 strike, British Coal has pursued its corporate objectives by restructuring operations, introducing new technology and intensifying work. The reconstruction of industrial relations which has accompanied these changes is analysed with particular emphasis on developments at colliery level.
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    New technologies, employment shifts and gender divisions within the textile industry (1991)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 6 (1991), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article examines the implications of the restructuring of the textile industry. In particular, the interlinked themes of technical change, employment restructuring and gender divisions are explored. The tensions which exist between production process and labour process transformations are considered, and a possible policy framework is offered.
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    Worker support for technical change (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The Workplace Industrial Relations Survey shows that in the large majority of cases the introduction of new technology is supported by the workers affected and their union representatives. In contrast, organisational change receives a more mixed response. Case studies reveal some of the principal reasons for the contrasting reactions to different forms of change.
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    In the name of progress? skill and attitudes towards technological change (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article uses case study data to explore the relationship between skill and workers’attitudes to technological change. A detailed model of skill is constructed to examine whether and how jobs are deskilled. The influence of a range of skill-based and other factors on attitudes is then assessed.
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    Labour process analysis and socio-technical design: living apart together? (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the authors explore how the labour process approach and the socio-technical approach can be used in the process of design and redesign of production organizations. The implications of both approaches are looked at in several cases of work reorganization in Rotterdam harbour.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1990.tb00124.x
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    Technological change and worker participation in Europe (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article analyses the extent, evaluation and strategies for the future of employees, representatives and management regarding participation in technological change. The results from interviews in the UK, France, Germany, Italy and Denmark show a low level of involvement, particularly in strategic decision making, a positive evaluation of participation by practitioners and the intention to increase levels of involvement on both sides of industry.
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    Skilled maintenance work at British Telecom: findings from the Social Change and Economic Life Research Initiative (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Here the author examines the relationship of technical change and job skills amongst maintenance workers in telecommunications in Britain. It demonstrates that there are significant variations within different areas of such maintenance work and strongly challenges the notion that such maintenance work is subject to a generic process of deskilling in the present era.
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    Book Reviews (1990)
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    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviewed in this articleComputers in the Human ContextThe Technical Fix: Education, Computers and IndustryOffice Automation: The Labour Process and Women's Work in BritainManagerial Strategy for New TechnologyTelecommunications Policy and Management
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    Technology agreements and industrial relations in Belgium (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Belgium has a very developed system of national collective bargaining and as a result, it is one of the few countries with a national technology agreement. An analysis revealed that this agreement was not used very much. This article looks at the use and importance of technology agreements for unions.
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    Barriers to growth: skills and training in telematics (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Great claims have been made about the growth prospects of the telematics sector, the primary source of communications networks and services. However, this article argues that the telematics sector faces some formidable barriers to growth, especially with respect to skills provision.
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    New technology, new careers: the impact of company employment policy (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Both upskilling and deskilling theses are frequently at fault in treating the unit of analysis as the skill residing in a particular group of workers, when it is the intersecting roles and labour markets, established over a period of time by recruitment, training, and job design policies, which are analytically significant.
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    Clerical workers and information technology: gender relations and occupational change (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: A questionnaire and interview study of women office workers in the West Midlands, who had recently experienced technical change, is used to examine their perceptions both of changes in their jobs and of the implementation process. The consequences for women's opportunities are discussed.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1990.tb00118.x
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    Book reviews (1990)
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    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviewed in this articleWork-Oriented Design of Computer ArtifactsNew Technology in ContextStrategies for Success: Case Studies in Advanced Manufacturing TechnologyComputers and Democracy: A Scandinavian ChallengeTechnology and WorkOn Work: Historical, Comparative and Theoretical ApproachesPeople and Computers: how to evaluate your company's new technologyTechnology and Competition in the International Telecommunications IndustryTrading Technology: Europe and Japan in the Middle East
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    New office technology and the labour process in contemporary Japanese banking (1990)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 5 (1990), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Japanese banks account for the top nine of the world's ten biggest banks. Rationalization has led to increased control of employees in the sphere of labour management. This article examines labour management and working conditions in relation to the introduction of new office technology.
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    Computing occupations: organizational power, work transition and collective mobility (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The computing occupations are in a state of transition between a technical service and something more central to organizational power and decision-making. This process has had complex implications for the nature of computing work and for careers. There is no certainty that embryonic changes will carry through. But neither should the chances of these occupations of mounting a ‘collective mobility project’ be written off early.
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    URL: http://dx.doi.org/10.1111/j.1468-005X.1994.tb00049.x
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    The ‘transformation game’: information systems and process innovation in organizations (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: The relationship between new information and communication technology and organizations is the subject of considerable debate. So too is the nature of organizational transformation. ‘Business process re-engineering’, with its emphasis upon the strategic deployment of information systems, brings both debates together. But does it resolve any of the issues?
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    Transferring technology and expertise from universities to industry: Britain's Teaching Company Scheme (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Teaching Company Scheme programmes involve employing graduates known as Teaching Company Associates in companies on projects which are jointly supervised by academics and company staff. This article presents findings of a study of the effectiveness of these programmes in transferring university expertise in science, technology and management, to industry.
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    Taylorism, teams and technology in ‘reengineering’ work-organization (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article critically examines the phenomenon of ‘Reengineering’ (or Business Process Reengineering: as it is sometimes called) as a transfer of ‘just-in-time’ techniques developed in manufacturing to the office environment. The article concludes that its most likely diffusion will be for ‘downsizing’ and ‘cost-reduction’, and may result in a modest degree of success in only some of its applications to manufacturing and office environments.
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    Analyzing an industry in change: the Irish software manual printing industry (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article is concerned with the application in a case study of three inter-related theoretical issues: new perspectives on technological change, learning organizations, and the question of market versus hierarchy in the relationships between firms. The case study is of the software manual printing industry in Ireland, and its relationship with the major, international software companies.
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    Skill, gender and technical change in a Nordic environment: typesetting in Iceland and Sweden (1994)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Drawing on empirical material from comparative research on jobbing printing in Iceland and Sweden, the author argues that the typesetting process has been subjected to deskilling, and he stresses that the development has been far more complex than often is realised. He concludes that gender, firm size, and production run and variety, must be considered in order to explain the diversity in the typesetting process.
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    Volvo human-centred work organization—the end of the road? (1993)
    Oxford, UK : Blackwell Publishing Ltd
    New technology, work and employment 8 (1993), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Volvo recently announced the closure of their factories at Kalmar and Uddevalla which were internationally renowned for the innovative methods of work organization as an alternative to the assembly line. In this and the following article the authors question the rationale of management's reasons for the closure, and assess the effect of the closures for those social scientists who saw Volvo as a shining example of work redesign
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    Book reviews (1994)
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    New technology, work and employment 9 (1994), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Book reviews in this article:Technclogy in Working Order: Studies of Work, Interaction, and Technology Graham Button (Ed.)Communication, Technology and the Development of People Bernard WoodsPhotonic Technology and Industrial Policy: US Responses to Technological Change Ernest StembergBeyond Taylorism: Computerization and the New Industrial Relations Lorraine GiordanoJapanization at Work John BrattonWorking for the Japanese Stephanie JonesTechnology and Work in German Industry Norbert Altmann, Christoph Kohler and Pamela Meil (Eds.)Towards Global Localisation: The Computing and Telecommunications Industries in Britain and France Philip Cooke, Frank Moulaert, Erik Swyngedouw, Olivier Weinstein, Peter Wells, Martine Lemattre and Patrice GrevetNew Technology and Practical Police Work S. Ackroyd, R. Harper, J. A. Hughes, D. Shapiro and K. Soothill
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    Kalmar and Uddevalla: The demise of Volvo as a European Icon (1993)
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    New technology, work and employment 8 (1993), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
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    New technology and Hong Kong telephone workers (1993)
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    New technology, work and employment 8 (1993), S. 0 
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    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Most studies of technological change in telecommunications have researched incremental shifts within the analogue switching paradigm. This paper takes the case of the shift to digital switching in Hong Kong's public telephone network. It focuses upon how this change was managed and the consequential changes in labour relations.
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    Control, technology and the management offensive in newspapers (1993)
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    New technology, work and employment 8 (1993), S. 0 
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    Notes: Here the author explores the dynamics of workplace control in the provincial newspaper industry, and argues that direct input technology has led to structural changes that shift the locus of control from the printers (typesetters/compositors) to the journalists (sub-editors) by increasing the latter group's influence over strategic contingencies in the production process.
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    The Formation of Congressional Tax Policy Regarding Family Firms: Comments from Daniel Rostenkowski (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Family business review 5 (1992), S. 0 
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    ISSN: 1741-6248
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
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    Book Reviews (1992)
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    Family business review 5 (1992), S. 0 
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    ISSN: 1741-6248
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: Books reviewed in this article: Passing the Torch: Succession, Retirement, and Estate Planning for Owners of Family Businesses (rev. ed.) by Mike Cohn. Loving Trust: The Smart, Flexible Alternative to Wills and Probate , by Robert A. Esperti and Renno L. Peterson. Leaving Money Wisely: Creative Estate Planning for Middle-and Upper-Income Americans for the 1990's , by David W. Belin.
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    URL: http://dx.doi.org/10.1111/j.1741-6248.1992.00227.x
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    The Problem of the Plateaued Owner-Manager (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Family business review 5 (1992), S. 0 
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    ISSN: 1741-6248
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: This article discusses the phenomenon of plateaued, or suboptimizing behavior, by owner-managers of smaller companies. While it may appear that owner-managers have every reason to enjoy their professions and maximize the value of their businesses, we assert that many owner-managers devote their energies to activities outside the business. The article examines not only symptoms and possible causes of this type of behavior but also offers some alternatives for overcoming this problem.
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    URL: http://dx.doi.org/10.1111/j.1741-6248.1992.00025.x
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    A Commentary: Alternative Uses of the Charitable Remainder Trust— Elaborating the Ideas of Hayes and Adams (FBR III:4) (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Family business review 5 (1992), S. 0 
    Details
    ISSN: 1741-6248
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1741-6248.1992.00077.x
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    PCR SSCP REVEALS HAPLOTYPE RELATED POLYMORPHISM OF PERB 1: A NEW MARKER FOR MHC β BLOCK TYPING (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Many new Major Histocompatibility Complex (MHC) genes have been discovered in the last 5 years. Defining the polymorphism of these new genes may elucidate their function and their relevance to diseases with MHC associations. Polymerase chain reaction and single stranded conformation polymorphism (PCR SSCP) analyses were used to detect sequence polymorphisms of PERB1 demonstrated by comparing the available genomic sequence of four haplotypes. This study showed that PCR SSCP of PERB 1 is reproducible. In addition, PERB1 alleles segregate within families together with MHC haplotypes. Typing results from the Forth Asia and Oceania Histocompatibility Workshop (4AOHW) cell panel indicate that the identified polymorphisms of PERB 1 are ‘haplotypic’, i.e., unrelated individuals carrying the same MHC ancestral haplotypes carry the same PERB1 SSCP pattern. Interestingly, PERB1 SSCP patterns allow the distinction of ancestral haplotypes which share HLA-B serological specificities, such as HLA-B44 and therefore this analysis can be used to further define MHC haplotypes and thus to improve our understanding of the evolution of this complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00216.x
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    THE ASSOCIATION BETWEEN COELIAC DISEASE, DERMATITIS HERPETIFORMIS AND CERTAIN HLA-ANTIGENS IN ICELANDERS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Twenty-eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland. Standard serological techniques were used for HLA typing. Twenty-five individuals with CD were typed, 21 (84%) of whom carried DR3, DQ2. Twelve of these 25 (48%) had DR3, DR7, DQ2, which makes them possibly homozygous for DQ2, and suggests that homozygosity of DQ2 increases the risk for CD. The four DH patients that were typed all had HLA-B8, DR3, DQ2. It is concluded that CD and DH are associated with DR3, DQZ in Icelanders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00218.x
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    T CELL RECEPTOR DELTA LOCUS POLYMORPHISM IN RHEUMATOID ARTHRITIS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In order to identify new susceptibility markers for Rheumatoid Arthritis (RA), we analysed the dinucleotide repeat polymorphism at the T cell receptor delta locus (TCRD) in 65 RA patients and 99 healthy Belgian controls. A significant under-representation of the A4-A5 TCRD genotype was observed in the RA population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00221.x
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    ANNOUNCEMENTS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00224.x
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    THE FIRST HLA ANTHROPOLOGICAL STUDY IN THE KUWAITI POPULATION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA antigens of the Kuwaiti population are not as well characterized as those of other international ethnic groups. We present results for HLA typing of Kuwaiti individuals using commercial Biotest sera. Six hundred and seventy one Kuwaiti were typed for HLA-A, -B, -C antigens and 399 were typed for HLA-DR, -DQ antigens. Antigen frequency and gene frequency were computed for each phenotype observed. The antigens with the highest frequencies were HLA-A2, A1 and A3; B5, B12 and B7; Cw″4 and Cw-l; DR52, DR5, DR3 and DR7; DQ1 and DQ2. HLA haplotypes with strong linkage disequilibrium and characteristic of Kuwaiti population are A2-B5, A1-B8, B7-DR7 and B8-DR3. A comparison study with other populations is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00200.x
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    MOLECULAR ANALYSIS OF CYP21 GENE MUTATIONS CARRIED ON HLA-B14 POSITIVE HAPLOTYPES (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-B14 positive haplotypes have increased frequencies in a group of patients with puberty disorders, IgA deficiency and cancer of the ovary. Clinical investigations demonstrated that all these patients have high values of 170H progesteron after the ACTH test which suggests an alterated function of 21 hydroxylase enzyme. In order to investigate whether these B14 positive haplotypes carry the same CYP21 mutation in the various diseases and controls, we have amplified by polymerase chain reaction (PCR) the sections of CYP21B gene which include amino acid positions 172 and 281 where typical mutations are known to occur in 21 hydroxylase deficiency. The presence or absence of the defined mutations was tested by oligonucleotide hybridization using oligonucleotides, labelled with DIG-ddUTP, designed to hybridize with the mutated or with the normal sequence. It was found that regardless of whether the subject tested was a patient or a healthy control the mutation at position 281 was found in all cases carrying HLA-B14, DR1 haplotype. Interestingly, this mutation does not seem to be in association with HLA-B14, DR7 haplotype.These findings suggest that CYP21 gene plays a role in all these differing diseases although it must be stressed that there may be alternative explanations for the observed data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00204.x
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    Gm and Km PHENOTYPE FREQUENCIES IN CHILDREN WITH CHRONIC ACTIVE HEPATITIS (CAH) B VIRUS INFECTION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Patients with CAH, extrahepatic HBV manifestation and healthy children were studied for presence of Gm 1,2,3,10,21 factors and Km 1 factor. Significantly higher frequency of Gm (1, 2, 3, 10, 21) phenotype was shown in CAH group as compared with the other two groups. Relationship between Km factors and examined groups was not found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00207.x
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    British Society for Histocompatibility and Immunogenetics (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00211.x
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    HLA-DQA1 AND DQB 1 ALLELE AND GENOTYPE CONTRIBUTION TO IDDM SUSCEPTIBILITY IN AN ETHNICALLY MIXED POPULATION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-DRB1, DQA1 and DQB1 alleles have been determined in 42 families with one IDDM proband and 64 healthy controls, by oligotyping (PCR-SSO) using primers and probes from the XI International Histocompatibility Workshop. A positive DRB1 *03 and DRB1 *04 association with the disease was observed, whereas DRB 1*11 and DRB 1 *07 showed negative association but 19% of patients carried DRB1 alleles different to DRB 1 *03 or *04. When single alleles were considered, DQA1 *03 showed the strongest association with susceptibility to the disease (RR = 8.2, Pc = 0.00001) but this association was outgrown by 2 and 3 allele combinations, with genotype DRB 1 *04-DQA 1 *03-DQB1*0302/DRB1*03- DQA 1*0501- DQB 1*0201 showing the strongest association (RR = 28, Pc = 0.002). Application of the relative predispositional effect (RPE) method to our data, revealed a further susceptibility risk provided by the DRB1*13-DQA1*0102-DQB 1*0604 haplotype once DR3 and DR4 haplotypes were removed. When DQA1-DQB1 genotypes were analysed for presence of Arg 52 (DQ α) and absence of Asp 57 (DQ β), genotypes SS/SS were found significantly increased in diabetics. Interestingly, one of the strongest associations with the disease was observed with the DQA 1*03-DQB 1*0201 combination encoded mainly by genes in trans (RR = 11.7 Pc = 0.00004). These observations and their comparison with DR-DQ haplotypes in more homogeneous ethnic groups support the stronger influence of the DQ molecule rather than the individual DR or DQ alleles in the susceptibility to IDDM. They also emphasize the need for detailed HLA haplotype studies in non-Caucasian and ethnically mixed populations to gain further insight into the nature of genetic and environmental factors contribution to autoimmunity.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00213.x
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    TNF Nco-I RFLP IS NOT AN INDEPENDENT RISK FACTOR IN RHEUMATOID ARTHRITIS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The human TNF genes are located within the MHC class-III region on chromosome 6. The presence or absence of an Nco-I restriction site in the 5’ non-coding sequence of the TNFβ gene defines two alleles (TNFB*1 and TNFB*2). The segregation of these alleles has been associated with levels of TNFα or TNFβ production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in healthy control individuals.Rheumatoid arthritis (RA) is characterized by high levels of TNFα within the synovial fluid and to address the question of whether this could be brought about by a genetic predisposition to high TNF production by RA individuals, we examined the distribution of this Nco-I polymorphism in 98 healthy volunteers and 123 patients with active rheumatoid arthritis. No difference was observed between the normal and RA groups with respect to haplotype segregation or allelic frequency. Furthermore, no difference was observed between DR4+ or DR4- individuals in the control or RA groups.These data demonstrate that the high level of TNFα seen in the joints of RA patients is unlikely to be due to a genetic predisposition of these patients to high TNFα production, as defined by the TNF Nco-I restriction fragment length polymorphism (RFLP).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00219.x
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    NOMENCLATURE FOR FACTORS OF THE HLA SYSTEM, 1994 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00222.x
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    INDICATIONS OF AN AUTOIMMUNE COMPONENT IN LP(a) ASSOCIATED DISORDERS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The exceptionally strong independent association found between Lp(a) lipoprotein [Lp(a)] levels and atherosclerotic disorders indicate that Lp(a) is a factor of considerable importance in the pathogenesis of atherosclerosis. The association between Lp(a) and diabetes, rheumatoid arthritis and renal diseases suggest that Lp(a) may be involved in immunological mechanisms.Lp(a) has a great tendency to aggregate and bind to glucosaminoglycans, fibrin and fibronectin and is preferentially retained in the extracellular matrix during development of atherosclerosis and is in vitro phagocytosed by macrophages, probably as small aggregates. It was previously found that the Lp(a) level is significantly related to the HLA class II genotype in male patients with early coronary artery disease. In this paper additional results of interleukin determinations in relation to HLA type and Lp(a) levels are presented and discussed. It is suggested that an autoimmune process, perhaps triggered by a concomitant intracellular infection may occur, especially in patients with inherited high Lp(a) levels in combination with certain inherited HLA class II genotypes.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00201.x
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    DPB1 LOCUS PCR-RFLP TYPING OF THE FOURTH ASIA-OCEANIA HISTOCOMPATIBILITY WORKSHOP CELL PANEL REVEALS A NOVEL DPB1 ALLELE (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: DPB1 locus typing of the 155 cell 4AOHW panel was performed using a PCR-RFLP method. Ambiguity of allele assignment was resolved by amplification using sequence-specific primers. Of the 150 cells for which typings were achieved, three exhibited unusual restriction enzyme fragment patterns, suggesting the possibility of novel DPB1 alleles. Sequence analysis revealed one allele present in the currently reported 46, one novel allele (4AOHW/107) not present among the 46, and one from a non-human primate which is being investigated. Twenty-six (26) of the 34 10IHW cells have been studied previously by cDNA RFLP, and strong haplotypic associations have been demonstrated between DPA1 and DPB1 locus alleles. It is proposed that exploitation of intron polymorphisms marking haplotypes will be an integral part of future DPB 1 typing as a ‘first-pass’ stratification process to minimize the requirement for sequence-based methods to definitively assign DPB 1 alleles.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00205.x
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    DISTRIBUTION OF HLA-A*28 ALLELES IN A SPANISH POPULATION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: DNA oligotyping was used to determine HLA-A28 subtypes in 25 unrelated Caucasian individuals living in or around Seville, Spain. Results showed that HLA-A*6802 was the most frequent allele, found in 14 individuals (53.8%), followed by HLA-68.3, which was present in eight subjects (30.8%), and both combined represented 84.6% of A28+ individuals in the area. The HLA-A*6801 allele was found in three individuals (11.5%), whereas HLA-A*6901 was present in one subject only (3.8%). Results indicate that the distribution of HLA-A28 alleles can vary among different Caucasoid populations. In this way, the high frequency obtained for A*6802 supports previous studies suggesting that the HLA-A*6802 allele was prevalent in people of the Mediterranean basin, in contrast to A*6801, prevalent in northern European populations.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00181.x
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    ANNOUNCEMENTS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00185.x
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    MHC IN SYSTEMIC LUPUS ERYTHEMATOSUS: A STUDY ON A KUWAITI POPULATION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA alleles were studied in Kuwaiti patients with Systemic lupus erythematosus (SLE). Although significant association of B5, B8, and DR3 has been reported in the literature, the most common phenotype for our patients is A3, DR2 as susceptible alleles and DQ1 as a protective gene.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00171.x
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    SEROLOGICAL IDENTIFICATION OF A NEW HLA-B7 VARIANT ANTIGEN –HLA-B7QUI (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A new HLA-B antigen, HLA-B7Qui that appears to be a variant of HLA-B7 has been identified. This antigen, which is HLA-Bw6 associated, reacts with approximately two-thirds of cytotoxic antisera stimulated by HLA-B7 or B27 that lack a B27 or B7 component, respectively. All anti-B7+27 antisera (stimulated by either B7 or B27) react with B7Qui as do most B22-stimulated sera possessing a B7 component. However, sera stimulated by B60, with or without a B7 component, fail to react with B7Qui.Family studies show the B7Qui allele to be unique to the haplotype –HLA-A32 CW6 B7Qui Bf*S C4A*6 C4B*1 DR11 DQ7 (GL02). Six Caucasoid subjects on the panel of 6861 HLA-typed potential bone marrow donors have this antigen (phenotype frequency, 0.08745%; gene frequency, 0.04473%). Work undertaken during the 11th International Histocompatibility Workshop (Reekers et al., 1992) showed that B7Qui has the same isoelectric point as HLA-B702 and HLA-B703 (Bpot) and that B7Qui is distinct from the HLA-B7 variants B703, B7SL, BDT, B7x40, BRI, and B41v.
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    CHARACTERIZATION OF HUMAN TERATOMA CELL LINES FOR THEIR IN VITRO DEVELOPMENTAL PROPERTIES AND EXPRESSION OF EMBRYONIC AND MAJOR HISTOCOMPATIBILITY LOCUS-ASSOCIATED ANTIGENS (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 8 (1981), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Five human teratoma cell lines have been characterized for the presence of a certain number of marker antigens whose presence or absence has been shown to be characteristic of mouse embryonal carcinoma (EC) cells. Four out of the five lines have been shown to respond to at least some of the criteria associated with murine EC cells even though only limited in vitro differentiation could be demonstrated. The significance of certain unusual marker antigen combinations present on the cell line Tera I and its clones and so far unobserved for the murine model is discussed. The observation in Tera I populations of cells carrying simultaneously both the F9 and β2-microglobulin or HLA antigens, suggest that the human cell lines may represent a novel material for the study of mammalian differentiation.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1981.tb00752.x
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    BOOK REVIEW (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 8 (1981), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Principles of Gene Manipulation. Studies in Microbiology
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1981.tb00753.x
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    GENE FREQUENCY AND LINKAGE DISEQUILIBRIUM ANALYSIS OF HLA-DRB1*04 HAPLOTYPES IN A SOUTH WALES POPULATION (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA-DRB1*04 allele frequencies have been determined in 184 HLA-DR4-positive unrelated blood donors from the South Wales area, using group-specific polymerase chain reaction (PCR) amplification and hybridization with sequence-specific oligonucleotide probes, PCR amplification with sequence-specific primers, and PCR single-strand conformation polymorphism analysis.Eight of the fifteen known HLA-DR4 sequences were detected in this study. Linkage disequilibrium analysis of HLA-DRB1 *04 and HLA-B, -DR and -DQ alleles revealed distinct haplotypic associations for all the major alleles detected in this population, including the novel linkage of HLA-B55 with DRB1*0407.These results are relevant to the role of HLA-DRB 1*04 haplotypes in determining allogeneic histocompatibility and disease susceptibility.
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    A CLASS I cDNA FROM SPAFAS LINE-11 CHICKENS (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A chicken MHC class I (B-F) cDNA from SPAFAS line 11 embryonic liver tissue was isolated and characterized by nucleotide sequencing. Comparing this sequence with previously described B-FcDNAs highlights clustered nucleotide substitutions in exon 3, encoding amino acids located on the a-helical region of the α2 domain.
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    HLA DOA-DQB HAPLOTYPES IN A SWEDISH POPULATION (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
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    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Samples from 94 Swedish blood donors were analysed for HLA-DQA1 and -DQB1 alleles by the PCR-SSO technique used in the XIth Histocompatibility Workshop. Seven DQA1 and 12 DQB1 alleles were identified and a total of 17 haplotype combinations were found deduced from the most probable allele combinations. Frequencies calculated from these haplotypes were compared to those calculated from the phenotypes according to Mattiuz et al. (1970). There was no significant difference in the frequencies of the 17 haplotype combinations deduced. Eight haplotype combinations had exactly the same frequencies and four had approximately the same frequencies independent of the calculation method used. The DQA1*0301-DQB 1*0302, DQA1*0501-DQB1*0201, DQA1* 0101-DQB1* 0501, and DQA1*0102-DQB1*0602 were the most frequent haplotypes with frequencies over 0.130.
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    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00166.x
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  • 91
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    British Society for Histocompatibility and Immunogenetics (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00168.x
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  • 92
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    T-CELL RECEPTOR α, δ, AND γ CHAIN GENES IN INSULIN-DEPENDENT DIABETES MELLITUS (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We have studied the genotypic, haplotypic, and allelic distribution of germline Restriction Fragment Length Polymorphism (RFLP) of T-cell receptor (Tcr) α, γ, and δ loci in 75 insulin-dependent diabetes mellitus (IDDM) patients and 84 healthy blood donors as control population. The restriction endonuclease PvuII produces three allelic fragments of Tcr C-γ (TcrCG) gene segment of 16,13, and 11.3 Kb respectively. Our observations revealed that PvuII/TcrCG RFLP allelic distributions were not significantly different in the IDDM and the control group. However, 85% of IDDM patients carried HLA DR3 and/or DR4 haplotypes, and when comparing these patients with a second group of HLA DR3+ and/or DR4+ healthy individuals, the 11Kb/PvuII fragment of TcrCG gene was found to be associated with IDDM patients (χ= 11.4, P= 0.003). 54.9% of IDDM patients carried at least one 11.3 Kb allele vs. 21% in controls (χ= 10.77, P = 0.004). No significant association was found between RFLP in Tcr, Cα, Cδ, Vγ9 loci and IDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00151.x
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  • 93
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    GENETIC CONTROL OF LEISHMANIA MAJOR INFECTION IN CONGENIC, RECOMBINANT INBRED AND F2 POPULATIONS OF MICE (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The outcome of subcutaneous infection with L. major NIH 173 was evaluated in a series of recombinant inbred and congenic strains, as well as F2 progeny generated from a genetic linkage testing stock carrying the visible markers Ra, Os, and Pt. The disease parameters monitored were the incidence of open or necrotic lesions and footpad depths of infected feet, and the incidence and number of amastigotes in livers following infection. Regions of mouse chromosomes 2, 4, 7, 8, 12 and 15 were excluded from linkage to a gene (Scl-1)involved in the susceptibility of inbred strains of mice to cutaneous infection with L. major NIH 173 by F2 and congenic strain analyses. Strain distribution patterns generated for Scl-1 in the CXB and CXS recombinant inbred strains suggested linkage to the distal end of mouse Chromosome 11.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00153.x
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  • 94
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    ROLE OF A GENETIC REGION ON CHROMOSOME 4 IN THE REGULATION OF NATURAL KILLER CELL ACTIVITY IN MICE (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Natural killer cell (NK) activity is regulated by both the H-2 and non-H-2 genes. Using bilineal congenic HW26C and HW13 mice which differ from the background strain C57BL/6By (B6) in a region of chromosome 4, we investigated the role played by a gene/genes in a segment of chromosome 4 of BALB/cBy on NK cell activity. Percoll separated low density spleen cells from young HW26C and HW13 mice showed a 3.5 fold higher NK activity than the B6. We also observed that the increase in NK activity of HW26C was not due to an increase in the number of NK cells. Using five other bilineal congenics containing different regions of chromosome 4 of BALB/cBy, we observed that the putative gene(s) regulating NK activity may be located between b and IFN-α/β genes of chromosome 4. The level of NK activity of (B6xHW26C)F1 ranked between the HW26C and B6 suggesting that the gene product described is inherited in an incompletely dominant fashion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00157.x
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  • 95
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    HLA CLASS II TYPING IN A MICROTITRE PLATE FORMATE USING DIGOXIGENIN-LABELLED AMPLIFIED DNA AND BIOTIN-LABELLED OLIGONUCLEOTIDE PROBES (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We describe a new, non-radioactive microtitre plate assay for the analysis of genetic variations at the DNA level. The new method combines hybridization of oligonucleotides with PCR amplified DNA in liquid phase with detection in solid phase using an elisa-reader. Genomic DNA is labelled with digoxigenin during PCR using a nucleotide mix containing DIG-11-2′-deoxy-uridine-5′-triphosphate (DIG-11-dUTP) DIG labelled, amplified genomic DNA is hybridized in solution with an oligon de which is labelled with one biotin at its 3′-end, using biotin-16,2′,3′-dideoxy ine-5′-triphosphate (BIO-16-ddUTP) and DNA deoxynucleotidylexo-transferase (TdT). The hybridized complex is immobilized in a streptavidin (SA) coated microtitre plate via the biotin and detection of digoxigenin is performed using anti-digoxigenin horseradish peroxidase, fab fragments (anti-DIG-POD), and the colorimetric substrate 2,2′-Azino-di-(3-ethylbenzthiazolinsulfonat[6]) (ABTS®). The resulting absorbtion of the assay is analysed in a microtitre plate reader. This method results in highly specific and sensitive hybridization signals and with the 15 oligonucleotides chosen, allows the typing of DR1-DR10.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00161.x
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  • 96
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    Electronic Resource
    A NEW Pk PHENOTYPE IN THE P BLOOD GROUP SYSTEM (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A healthy 22-year-old woman was noted to have erythrocytes of the Pk phenotype: a strong Pk antigen, no detectable P antigen and anti-P antibody in her serum. Her erythrocytes contained four to six times as much Pk glycolipid (globotriaosylceramide or CTH) and approximately half as much P glycolipid (globotertraosylceramide or globoside) as normal red cells. The structures of CTH and globoside were characterized by analysis of permethylated sugars and complement fixation in addition to chromaographic mobility and sugar composition. Inasmuch as the erythrocytes of two Pk individuals that were analysed previously (Marcus et al., 1976) contained no detectable globoside, these abnormalities appear o represent a new phenotype in the P blood group system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00738.x
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  • 97
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    HIGH FREQUENCY OF THE PROPERDIN FACTOR Bf F1 AND ITS LINKAGE TO HLA IN FRENCH BASQUES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We studied 201 unrelated French Basque individuals for HLA and Bf polymorphisms. The haplotypes of eighty-seven of them were deduced from family studies. The results show the frequency of the Bf F1 allele (0.1393) which is the highest one currently reported. They confirm the high frequencies of HLA-Aw19.2 and B18 previously reported in that population and show that a whole haplotype with strong linkage disequilibria, namely Aw19.2, Cw5, B18, Bf F1, DRw3 is frequent. On the other hand, the gene frequency of Bf S is decreased (0.5497) as compared with the other European Caucasoïd populations, while a slight increase in the Bf F gene frequency (0.2960) appears. These results point out that it is of importance to consider the genetic background in choosing the population where linkage disequilibria are to be studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00739.x
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  • 98
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    NON-H-2-LINKED GENETIC CONTROL OF RESISTANCE TO BALB/c FIBROSARCOMA METH-A (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 7 (1980), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The genetic control of hybrid resistance to BALB/c fibrosarcoma Meth-A was investigated. A Meth-A tumour grew slower in (BALB/c X C57BL/6)F1 and reciprocal hybrid mice than in syngeneic BALB/c mice and was also found to grow slower in females than in males. Significant F1 resistance was demonstrated after both subcutaneous and intraperitoneal injection of tumour cells. However, (BALB/c X DBA/2)F1 mice did not show any significant resistance to Meth-A. In H-2 linkage studies of [BALB/c X (BALB/c X C57BL/6)] backcross mice, no statistically significant differences in the resistance of H-2 heterozygotes and homozygotes to Meth-A were observed. These results indicated that F1 hybrid resistance to Meth-A was controlled by non-H-2-linked resistance factor(s). No linkage was observed between resistance to Meth-A and coat colour c- and b-loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00740.x
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  • 99
    Electronic Resource
    Electronic Resource
    Nomenclature for human complement factor B (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In this note is recommended a unified nomenclature for allotypes and variants of human complement factor B, which was approved by the Nomenclature Committee of the International Union of Immunological Societies (IUIS).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00149.x
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  • 100
    Electronic Resource
    Electronic Resource
    QUANTITATION OF HLA CLASS II ANTIGENS ON B-CELL LINES (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: By quantitation of elutable immunoglobulin G in a recently described elisa, the number of HLA class I and II molecules on B-cell lines was determined using monomorphic monoclonal antibodies. An average number of 183 000 binding sites per cell for HLA class I-, 99000 for HLA-DR-, 63000 for DQ- and 42000 for DP-specific monoclonal antibodies were determined. The small amount of HLA class II molecules can in part explain the difficulties observed in HLA class II typing or in detection of class II antibodies using the lymphocytotoxicity text.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1993.tb00109.x
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