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HIGH FREQUENCY OF THE PROPERDIN FACTOR Bf F1 AND ITS LINKAGE TO HLA IN FRENCH BASQUES (1980)

Ohayon, E. ; Mouzon, A. de ; Hauptmann, G. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

International journal of immunogenetics 7 (1980), S. 0

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ISSN: 1744-313X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: We studied 201 unrelated French Basque individuals for HLA and Bf polymorphisms. The haplotypes of eighty-seven of them were deduced from family studies. The results show the frequency of the Bf F1 allele (0.1393) which is the highest one currently reported. They confirm the high frequencies of HLA-Aw19.2 and B18 previously reported in that population and show that a whole haplotype with strong linkage disequilibria, namely Aw19.2, Cw5, B18, Bf F1, DRw3 is frequent. On the other hand, the gene frequency of Bf S is decreased (0.5497) as compared with the other European Caucasoïd populations, while a slight increase in the Bf F gene frequency (0.2960) appears. These results point out that it is of importance to consider the genetic background in choosing the population where linkage disequilibria are to be studied.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1744-313X.1980.tb00739.x

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