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  • Chemistry  (101,586)
  • Physics  (5,775)
  • INSTRUMENTATION AND PHOTOGRAPHY
  • 1995-1999  (39,119)
  • 1980-1984  (37,652)
  • 1975-1979  (33,147)
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  • 1
    Unknown
    Amsterdam ; New York : North-Holland Pub. Co
    Keywords: DDC 530.1 ; LC QC20 ; Mathematical physics ; Physics ; Quantum theory ; Relativity (Physics)
    ISBN: 9780444875853
    Language: English
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  • 2
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    In:  J. Geophys. Res., Warszawa, American Geophysical Union, vol. 103, no. B7, pp. 15,239-15,253, pp. L08304, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Stress ; Rock mechanics ; Fracture ; Physical properties of rocks ; Laboratory measurements ; 5104 ; Fracture ; and ; flow ; 8010 ; Structural ; geology ; Fractures ; and ; faults ; 8168 ; Tectonophysics ; Stresses--general ; 8439 ; Volcanology ; Physics ; and ; chemistry ; of ; magma ; bodies ; Muller ; JGR
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  • 3
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    In:  J. Geophys. Res., Kalamazoo, Michigan 49001, The Upjohn Company, vol. 103, no. B8, pp. 18,295-18,324, pp. L09603, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Elasticity ; Volcanology ; 8434 ; Volcanology ; Magma ; migration ; 8145 ; Tectonophysics ; JGR ; Physics ; of ; magma ; and ; magma ; bodies ; 8414 ; Eruption ; mechanisms
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  • 4
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    In:  Geophys. Res. Lett., New York, Conseil de l'Europe, vol. 25, no. 12, pp. 2237-2240, pp. B06307, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Volcanology ; Earthquake precursor: chemical (Rn, water(-level,...) ; TIDES ; Earth tides ; Physical properties of rocks ; 8135 ; Tectonophysics ; GRL ; Hydrothermal ; systems ; (8424) ; 8439 ; Volcanology ; Physics ; and ; chemistry ; of ; magma ; bodies ; 7223 ; Seismology ; Seismic ; hazard ; assessment ; and ; prediction ; 1832 ; Hydrology ; Groundwater ; transport
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  • 5
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    In:  Geophys. Res. Lett., Kobe, 1, vol. 26, no. 23, pp. 3437-3440, pp. 8010, (ISBN: 0534351875, 2nd edition)
    Publication Date: 1999
    Description: The formation of ocean crust along the midocean ridge system is volumetrically one of the most important geological processes on the surface of the earth. Volcanic eruptions along the ridge can be catastrophic events during which magma rises to the surface of the sea floor to release heat and gases into turbulent megaplumes that disrupt the overlying water column, initiate and rejuvenate hydrothermal circulation, and trigger an outpouring of microbial debris. Though these events may persist only a few weeks or months at one site, taken together, they may play a major role in the oceanic biogeochemical cycle. Axial Volcano on the Juan de Fuca Ridge has become a laboratory for the study of ephemeral aspects of sea floor volcanism, including results from expeditionary, rapid response, and permanent instrument installations. The geological context and description of the most significant magmatic event on the Juan de Fuca Ridge in the past decade is provided by Embley et al. [3425]. Dziak and Fox [3429], describe a rapid increase in the seismicity remotely monitored by the U.S. Navy hydrophone array. The increase in seismic swarms is the earliest indicator that an eruption has begun. Within hours, volcanic deflation is observed in concert with increases in the bottom water temperature due to venting. Instruments in place for the first time during such a midocean ridge volcanic event measured ground deformation and caldera subsidence resulting from the extraction of magma as described by Fox [3437] and Chadwick et al. [3441], while a coincident outpouring of hot water recorded on moored temperature sensors is described in Baker et al. [3445]. A rapid response cruise in February brought researchers to the site only 14 days after the eruption began and in the midst of winter storms. Sohn et al. [3433] describe local seismicity derived from a network of sea floor hydrophones deployed during the February cruise. Repeated measurements of helium anomalies in the water column before and after the eruption are used by Lupton et al. [3449] to fingerprint the hydrothermal plume associated with the eruption, extending a considerable distance off-axis. Water samples collected during the February 1998 cruise were analyzed for hydrothermal methane and hydrogen by McLaughlin-West et al. [3453]. They find both species to be significantly elevated near the vents and invoke microbial processes to explain the observations.
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Volcanology ; 3035 ; Marine ; geology ; and ; geophysics ; Midocean ; ridge ; processes ; 8145 ; Tectonophysics ; Physics ; of ; magma ; and ; magma ; bodies ; 8419 ; Volcanology ; Eruption ; monitoring ; (7280) ; 8434 ; Magma ; migration ; GRL
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  • 6
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    In:  Geophys. Res. Lett., London, Pergamon, vol. 24, no. 13, pp. 1559-1562, pp. B05401, (ISBN: 0534351875, 2nd edition)
    Publication Date: 1997
    Keywords: Volcanology ; Stress ; Iceland ; 8145 ; Tectonophysics ; Physics ; of ; magma ; and ; magma ; bodies ; 8414 ; Volcanology ; Eruption ; mechanisms ; GRL
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  • 7
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    In:  Geophys. Res. Lett., Dordrecht, National Academy of Sciences of the USA, vol. 24, no. 15, pp. 1843-1846, pp. TC5003, (ISSN: 1340-4202)
    Publication Date: 1997
    Keywords: Iceland ; SAR ; InSAR ; Plate tectonics ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; 1209 ; Geodesy ; Gravimetry, Gravitation ; 8145 ; Tectonophysics ; Physics ; of ; magma ; and ; magma ; bodies ; 8150 ; Plate ; boundary ; general ; Massonet ; (3040) ; 3035 ; Marine ; geology ; and ; geophysics ; Midocean ; ridge ; processes ; Volcanology ; GRL
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  • 8
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    In:  Geophys. Res. Lett., Hannover, Dt. Geophys. Ges. e. V., vol. 25, no. 10, pp. 1549-1552, pp. 1058, (ISSN: 1340-4202)
    Publication Date: 1998
    Keywords: Volcanology ; Modelling ; InSAR ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; 1243 ; Geodesy ; and ; gravity ; Space ; geodetic ; surveys ; 3210 ; Mathematical ; geophysics ; (new ; field) ; Modeling ; 8145 ; Tectonophysics ; Physics ; of ; magma ; and ; magma ; bodies ; 8499 ; Volcanology ; General ; or ; miscellaneous ; GRL
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1996-02-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubes, G -- New York, N.Y. -- Science. 1996 Feb 9;271(5250):767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8628989" target="_blank"〉PubMed〈/a〉
    Keywords: Behavioral Sciences ; *Computer Communication Networks ; Costs and Cost Analysis ; Peer Review, Research ; *Periodicals as Topic/economics/standards ; Physical Phenomena ; Physics ; *Publishing/economics/standards
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-10-13
    Description: Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentzepis, P M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):174-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694523" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Electrons ; *Kinetics ; Lasers ; Protons ; *Retinal Pigments ; *Rhodopsin ; Spectrum Analysis/*methods ; Temperature ; *Vision, Ocular
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-08-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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  • 13
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Keywords: Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-07-20
    Description: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-05-06
    Description: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-01-20
    Description: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-10-19
    Description: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-08-31
    Description: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Keywords: Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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  • 21
    Publication Date: 1984-10-19
    Description: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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  • 22
    Publication Date: 1984-08-31
    Description: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-05-11
    Description: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Keywords: Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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  • 24
    Publication Date: 1983-12-16
    Description: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-03-16
    Description: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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  • 26
    Publication Date: 1984-11-16
    Description: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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  • 27
    Publication Date: 1984-06-15
    Description: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Keywords: Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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  • 28
    Publication Date: 1984-11-02
    Description: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-09-09
    Description: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1984-06-08
    Description: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-03-17
    Description: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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  • 32
    Publication Date: 1980-01-04
    Description: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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  • 33
    Publication Date: 1981-10-16
    Description: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Keywords: Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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  • 34
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-05-15
    Description: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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  • 35
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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  • 36
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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  • 37
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-12-11
    Description: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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  • 38
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-01-30
    Description: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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  • 39
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-03-13
    Description: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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  • 40
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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  • 41
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 42
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1983-06-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Keywords: Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 43
    Publication Date: 1983-05-06
    Description: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Keywords: Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 44
    Publication Date: 1983-04-15
    Description: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Keywords: Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 45
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-04-07
    Description: Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Gabbay, K H -- Gallop, P M -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):21-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635569" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Glucose/metabolism ; Chemical Phenomena ; Chemistry ; Diabetes Complications ; Diabetes Mellitus/*blood/diagnosis ; Diphosphoglyceric Acids/blood ; Glycosides/blood ; Glycosuria/etiology ; Hemoglobin A/*metabolism ; Hemoglobins/*analysis/*metabolism ; Humans ; Kinetics ; Oxygen/blood ; Structure-Activity Relationship
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 46
    Publication Date: 1979-06-08
    Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 47
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 48
    Publication Date: 1980-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 49
    Publication Date: 1984-05-25
    Description: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 50
    Publication Date: 2004-12-03
    Description: This paper reports a new balance for the measurement of three components of force - lift, drag and pitching moment - in impulsively starting flows which have a duration of about one millisecond. The basics of the design of the balance are presented and results of tests on a 15 deg semi-angle cone set at incidence in the T4 shock tunnel are compared with predictions. These results indicate that the prototype balance performs well for a 1.9 kg, 220 mm long model. Also presented are results from initial bench tests of another application of the deconvolution force balance to the measurement of thrust produced by a 2D scramjet nozzle.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Shock Tunnel Studies of Scramjet Phenomena 1993; p 107-112
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  • 51
    Publication Date: 2011-08-24
    Description: The concept of the well-known Langley plot technique, used for the calibration of ground-based instruments, has been generalized for application to satellite instruments. In polar regions, near summer solstice, the solar backscattered ultraviolet (SBUV) instrument on the Nimbus 7 satellite samples the same ozone field at widely different solar zenith angles. These measurements are compared to assess the long-term drift in the instrument calibration. Although the technique provides only a relative wavelength-to-wavelength calibration, it can be combined with existing techniques to determine the drift of the instrument at any wavelength. Using this technique, we have generated a 12-year data set of ozone vertical profiles from SBUV with an estimated accuracy of +/- 5% at 1 mbar and +/- 2% at 10 mbar (95% confidence) over 12 years. Since the method is insensitive to true changes in the atmospheric ozone profile, it can also be used to compare the calibrations of similar SBUV instruments launched without temporal overlap.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; D2; p. 2997-3004
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  • 52
    Publication Date: 2004-12-04
    Description: An improved 4 to 18 micron array camera system was developed at NASA Goddard SFC for astronomical photometry, using an Aerojet Electro Systems Corp. 16 x 16 Si:Bi accumulation mode charge injection device (AMCID) which could be suitable for eventual low-background spaceflight applications. An astronomical observing program using this device was carried out as a collaboration between NASA Goddard (Infrared and Radio Astronomy Branch and Micro Electronics Branch), the Harvard/Smithsonian Center for Astrophysics, and Steward Observatory of the University of Arizona. In 1983 the camera system was revised, and a new Aeroject Si:Bi array with 16 x 16 active pixels was obtained from NASA/Ames Research Center as part of a new scientific collaboration between the Ames and Goddard infrared array research groups. The 16 x 16 device had sufficiently good sensitivity, uniformity and noise characteristics to be used for successful observations at the Mt. Lemmon 60 and 61 inch telescopes in May 1983. Complete laboratory characterization of the 16 x 16 array was carried out in summer of 1983. Initial results indicate that this detector has sensitivity and noise characteristics comparable to other devices from the same generation of Aerojet arrays.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Ames Research Center, Infrared Detector Technology Workshop; 12 p
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  • 53
    Publication Date: 2006-02-14
    Description: The use of laser holography for measuring the distortion of antennas under space simulation conditions is described. The subject is the so-called double exposure procedure which allows to measure the distortion in the order of 1 to 30/micrometers + or - 0.5 per hologramme of an area of 4 m diameter max. The method of holography takes into account the constraints of the space simulation facility. The test method, the test set up and the constraints by the space simulation facility are described. The results of the performed tests are presented and compared with the theoretical predictions. The test on the K-Band Antenna e.g., showed a distortion of approximately 140/micrometers + or - 5/micrometers measured during the cool down from -10 C to -120 C.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center 13th Space Simulation Conf.; p 309-319
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  • 54
    Publication Date: 2006-02-14
    Description: Conventional schemes for digitizing large volumes of photographic data are far too costly and time consuming to encourage the undertaking of the ambitious projects using traditional technology. There is a distinct need for fast digitizing systems such as could be derived from development of large format, optically multiplexed CCD systems designed to address these problems. The use of CCD chips for data handling and the capability of using polaroids in the optical path for reduced light scattering are discussed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 419-427
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  • 55
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    In:  CASI
    Publication Date: 2006-02-14
    Description: Parameters of the UK 1.2 meter Schmidt telescope are described. Plates taken with this instrument are in two categories, those for systematic sky surveys and those taken at the request of research users. A collaborative project with the European Southern Observatory was undertaken to obtain a two-color survey of the sky south of -20 deg declination to complement the Palomar survey. A near infrared survey of the Galactic Plane and the Megallanic Clouds is being done. The area south of -20 deg and the zone between 0 deg and -15 deg are also being surveyed. Pending a decision on survey parameters, all available A quality prism plates are being retained to form a basis for systematic survey. Nearly half the plates taken on a service basis for the UK astronomical community are to fulfill nonsurvey requests. Plates taken for surveys which are not of A grade quality are also made available for research purposes.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 379-385
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  • 56
    Publication Date: 2006-02-14
    Description: Some software facilities used mainly for information retrieval and analysis at the Padova-Asiago Observatory are discussed. These facilities help guest and resident astronomers to make easier the preparation of plate measurements. The problems connected with the creation, use and management of a data base in a scientific (astronomical) environment are reviewed on the basis of the experience gathered during the last three years. The development plan of the user session environment and its possible applications in a computer network are briefly sketched.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 361-369
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  • 57
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    In:  CASI
    Publication Date: 2006-02-14
    Description: A 256 diode-array will be installed as detector on the ESO OPTRONICS S-3000 measuring machine in order to increase the acquisition rate. A high intensity LED will be used as light source in a pulse mode. The data will be stored on a random access mass storage device as density values for later education. The scanning time for a 30 cm x 30 cm plate with a step size of 10 micron will be less than 10 hours while the dynamic range of the data is expected to be 2.5 density units with an offset of at least 1 unit.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 317-328
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  • 58
    Publication Date: 2006-02-14
    Description: The design and performance of the automated photographic measuring facility at Cambridge is described. It consists of a precision laser scanning microdensitometer connected to a series of computers that process the data on-line. Plates up to 350 mm square can be measured. The microdensitometer samples the plate to 12 bit accuracy at a speed of 230,000 samples/second. The positional accuracy is better than a micron. Other features include platen rotation and automatic focus.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 277-288
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  • 59
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The expected performance of the Minnesota automated dual-plate scanner (APS) is discussed with regard to photometry, position measurement accuracy, and ability to classify images. In addition, a fast algorithm for calculating image parameters is described.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 267-276
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  • 60
    Publication Date: 2006-02-14
    Description: Various aspects of the performance of the PDS 1010A microdensitometer are described. The primary points in an upgrade propsal for the unit are outlined. Photometric instabilities in the PDS are mentioned.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 129-134
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  • 61
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    In:  CASI
    Publication Date: 2006-02-14
    Description: Minor modifications of electronic components in the PDS 1010A microdensitometer are discussed. The operational requirements and performance limitations of the PDS are noted. Replacement of the photomultiplier and front-end analog circuitry significantly improved the photometric performance of the PDS. The improvement in density repeatability is marked, and the permissible density slew speed is greatly increased.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 121-128
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  • 62
    Publication Date: 2006-02-14
    Description: High Altitude Observatory HAO microdensitometer undergoes monthly testing to assure its consistent performance. These tests check positional and photometric stability at the 10 micron aperture level. The HAO test procedure is designed to run without operator intervention following initial configuration of the microdensitometer for each subprocedure. Specialized test software is resident in the PDP 8. The operator selects the proper subprocedure by entering commands. Once computer control is established, it is not relinquished until the test is complete.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Astron. Microdensitometry Conf.; p 19-34
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  • 63
    Publication Date: 2006-02-14
    Description: A number of diagnostic tests are developed for the Photometric Data System PDS 2020G microdensitometer to monitor its performance and to isolate various electromechanical problems. A number of tests which help to diagnose problems with the photometer, positional accuracy and data collection are described. The tests include: (1) scanning a razor blade edge to study the response of the photometer and zero point losses in the coordinate system, (2) scanning a long straight line to evaluate the drunkness of the stage motions, (3) scanning photometric step wedge calibrations to study the response of the photometer, and (4) measurement of a series of high signal to noise plates of the same region of the sky to evaluate the overall performance of the microdensitometer. A variety of electronic tests to isolate electromechanical problems are also performed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 3-18
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  • 64
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The behavior of ruled and holographic gratings with various coatings after extended exposure to the space environments was examined. The coatings and differentiating between the influences of vacuum and solar illumination were examined. In the past, several ruled and holographic gratings with various coatings were successfully flown on rocket experiments. Future utilizations of such gratings are considered for the Space Telescope and for various Spacelab projects under development. The techniques which is used to replicate gratings can also be used to obtain a wide range of lightweight optical components, including sophisticated aspherical, highly polished mirrors.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 163-164
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  • 65
    Publication Date: 2006-02-14
    Description: Electro-optic holographic recording systems were developed. The spaceworthiness of electro-optic crystals for use in ultrahigh capacity space data storage and retrieval systems are examined. The crystals for this experiment are included with the various electro-optical components of LDEF experiment. The effects of long-duration exposure on active optical system components is investigated. The concept of data storage in an optical-phase holographic memory is illustrated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 152-153
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  • 66
    Publication Date: 2006-02-14
    Description: The specific scientific objectives of this experiment are to measure the spatial distribution, size, velocity, radiance, and composition of microparticles in near-Earth space. The technological objectives are to measure erosion rates resulting from microparticle impacts and to evaluate thin-foil meteor 'bumpers'. The combinations of sensitivity and reliability in this experiment will provide up to 1000 impacts per month for laboratory analysis and will extend current sensitivity limits by 5 orders of magnitude in mass.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Langley Research Center Long Duration Exposure Facility (LDEF); p 117-120
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  • 67
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    In:  CASI
    Publication Date: 2006-06-04
    Description: The active cavity radiometer (ACR) experiment on the Spacelab 1 mission to measure the total solar irradiance is discussed. Short and long term variations in the total solar output of optical energy are studied. Solar total irradiance observation provides information on the solar cycle and other long term trends in solar output that are of climatological significance as well as short term solar physics phenomena. The interaction of solar radiation with the Earth's atmosphere, oceans, and land masses provides the primary driving forces for the formation of weather systems and the determination of climate. Astrophysical measurements determine the total energy flux. The principal role of the ACR observations support extended solar irradiance experiments on free flying satellites. Solar irradiance measurements are important in the establishment of the radiation scale at the solar total flux level in the international system of units (SI).
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 4 p
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  • 68
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    In:  CASI
    Publication Date: 2006-06-04
    Description: The study of galactic and faint extragalactic extended sources and peculiar ultraviolet objects by a very wide field of view camera, operated in the ultraviolet photometric and spectrometric modes is discussed. The photometric mode is direct photography through filters for observation of the following sources: (1) large scale distribution of ultraviolet radiation in the Milky Way; (2) diffusion of the galactic light above the galactic plane and in front of the large absorbing clouds; (3) the optical emission of the interstellar matter; (4) stars, and starlike objects with diameters less than 3 arc minutes. In the spectrometric mode (nebular spectrograph) the light from the center of the photometric field is concentrated on a slit covering 10 degrees by 10 arc minutes on the sky.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 3 p
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  • 69
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    In:  CASI
    Publication Date: 2006-06-05
    Description: The use of a personal miniature electrophysiological tape recorder to measure the physiological reactions of space flight personnel to space flight stress and weightlessness is described. The Oxford Instruments Medilog recorder, a battery-powered, four-channel cassette tape recorder with 24 hour endurance is carried on the person and will record EKG, EOG, EEG, and timing and event markers. The data will give information about heart rate and morphology changes, and document adaptation to zero gravity on the part of subjects who, unlike highly trained astronauts, are more representative of the normal population than were the subjects of previous space flight studies.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 2 p
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  • 70
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-06-04
    Description: A test of the mapping capabilities of high resolution space photography taken at the resolution limit of image motion on large film format is planned. The metric camera system and its planned operation are described.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 4 p
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  • 71
    facet.materialart.
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    In:  CASI
    Publication Date: 2006-06-04
    Description: Photography and measurement of cloud-like structures of bright parallel bands observed in near infrared photography of the night sky is planned. The instrument is described and the purpose of the experiment summarized.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 2 p
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  • 72
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    In:  CASI
    Publication Date: 2006-06-04
    Description: High resolution infrared spectroscopic observations of the Earth's limb in the wavelength range characteristic of the vibrational-rotational lines of trace atmospheric constituents is planned. The instrument and its operation and the purpose of the experiments are summarized.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center Spacelab Mission 1 Expt. Descriptions; 3 p
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  • 73
    Publication Date: 2006-02-22
    Description: The measurement capabilities of laser velocimetry and holographic interferometry in transonic airfoil testing were demonstrated. Presented are representative results obtained with these two nonintrusive techniques on a 15.24 cm chord airfoil section. These results include the density field about the airfoil, flow angles in the inviscid flow and viscous flow properties including the turbulent Reynolds stresses. The accuracies of the density fields obtained by interferometry were verified from comparisons with surface pressure and laser velocimeter measurements.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Langley Res. Center Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 589-599
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  • 74
    Publication Date: 2006-02-22
    Description: Two dimensional airfoil testing was conducted at the Wichita State University Beech Wind Tunnel for a number of years. The instrumentation developed and adapted during this period of testing for determination of flow fields along with traversing mechanisms for these probes are discussed. In addition, some of the techniques used to account for interference effects associated with the apparatus used for this two dimensional testing are presented. The application of a minicomputer to the data reduction and presentation is discussed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Langley Res. Center Advanced Technol. Airfoil Res., Vol. 1, Pt. 2; p 539-558
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  • 75
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The counter is a static thermal diffusion chamber which has been modified to include an optical system for the determination of droplet concentration by the measurement of scattered light. The determination of concentration is made by measurement of the peak scattered light signal from the cloud of growing droplets which is a function of both the droplet concentration and chamber supersaturation. Because the formation of the peak is related to the rate of growth of the droplets and sedimentation, both of which are determined by supersaturation, the system calibration can be uniquely determined by comparison with an absolute counter such as a static diffusion chamber with a photographic recording system.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 40-41
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  • 76
    Publication Date: 2006-02-14
    Description: Unlike typical CCN counters, this device counts the numbers of water droplets condensed on aerosol particles sampled on a microcover glass at various different relative humidities. The relative humidities ranged from 75 percent to a calculated value of 110 percent. A schematic of the apparatus is shown. The individual CCN can be identified in an optical micrograph and scanning electron micrograph and may be inspected for their chemical composition later.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 35-36
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  • 77
    Publication Date: 2006-02-14
    Description: In performing the data analysis of the measurements achieved during the Workshop with the device, a global approach was preferred rather than an individual analysis, in order to illustrate some main characteristics in the behavior of the device with respect to a mean behavior resulting from a general survey of all the equipments involved in each experiment. The device tends generally to overestimate the CCN concentrations measured near the high supersaturations and sometimes underestimates the concentrations close to 0.1% or 0.2% of supersaturation. Despite the fact that it belongs to a type of static diffusion chamber, it shows, however, similar spectra to those obtained with other types of chambers (continuous flow diffusion chamber and haze chamber).
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 17-19
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  • 78
    Publication Date: 2006-02-14
    Description: The group's CCN counter is described. It is a static, horizontal, parallel plate thermal gradient diffusion chamber. Examples of the application of the CCN are presented and include the CCN spectra measured during the winter of 1978-79 near Elk Mountain, Wyoming. Comparisons of droplet concentrations derived from upwind CCN spectra are covered.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 11-13
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  • 79
    Publication Date: 2006-02-14
    Description: A parallel beam of X-rays (approximately monoenergetic) passing through a rectangular slit and scattering from two flat mirrors comprise the X-ray test. The two mirrors are arranged in a periscope geometry so that the final reflected beam is parallel to the incident beam but displaced laterally by given amount. One of the detectors used to intercept the reflected X-rays is a one dimensional gas-filled proportional counter which is sensitive to the position (in 1 dimension) at which the X-rays are incident within its detecting "window". The total length of the anode wire of the proportional counter is 120 mm and this length can be divided electronically into a maximum of 1,024 parts. Hence, the output of an experimental run would be the number of incident X-rays that registered on each of the 1,024 channels. Each channel would represent an X-ray at a different spatial location and, hence, at a different scattering angle. In order to look at a wider range of scattering angles, the detector is placed on an optical table which can be rotated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 6 p
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  • 80
    Publication Date: 2006-02-14
    Description: The size distribution was measured in the size range between 0.0057 and 0.57 micrometer radius. A description of the instrumentation and data analysis is given, together with the measured size distributions calculated for 23 experiments.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 69-78
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  • 81
    Publication Date: 2006-02-14
    Description: The experiments performed at the Workshop were undertaken to confirm the calculated sample volume, determine the usable range of supersaturation, and minimum detectable size. Comparison of absolute CCN concentrations with other state-of-the-art continuous flow diffusion chambers at supersaturations near 1 percent indicated that the volume used produced CCN concentrations well within the range of CCN concentrations determined at the workshop. This agreement is interpreted to mean the sample volume was correct. Direct measurements of the beam geometry done in the laboratory indicated a factor of 4-5 error. This error is apparently due to the larger apparent visible beam diameter versus the actual usable beam diameter given the droplet illumination, chamber optical geometry, microscope optics and film characteristics.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 44-45
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  • 82
    Publication Date: 2006-01-16
    Description: A multi-channel chopper system designed and built to stringent specifications is providing an excellent performance for a total ozone mapping spectrometer (TOMS). State of the art machining technology, suitable material selection, and a way to hold and position the slit plate resulted in the instrument's better than expected performance. A shutter method used for internal calibration allows compensation for the occurrence of an unlikely wavelength shift during testing, launch, or during the orbiting life of the instrument. The TOMS is part of a payload on Nimbus 7 launched on October 24, 1978.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center The 15th aerospace Mech. Symp.; p 63-75
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  • 83
    Publication Date: 2006-02-14
    Description: A brief comparative description is made of the chambers. Overall, comparisons for the various types of experiments - monodisperse, polydisperse and ambient aerosol - showed agreement among these chambers to within 15% in most cases. A careful analysis of the results indicated that a proper accounting of certain parameters would bring about much closer agreement among four of these instruments.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Third Intern. Cloud Condensation Nuclei Workshop; p 79-84
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  • 84
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    In:  CASI
    Publication Date: 2006-02-14
    Description: In the IHC the critical supersaturation is inferred from the measurement of the size of particles which have grown to their equilibrium size at exactly 100 percent RH. The largest size channel corresponds to a critical supersaturation of 0.014 percent. The growth time required for particles of this size to reach their equilibrium size exceeds the 110 second residence time in the IHC. Since the supersaturation spectrum is always very steep in this region, the contribution of these larger particles which have not yet attained their equilibrium size to smaller size channels is negligible. However, failure of these particles to reach their equilibrium size could result in a significant lowering of the count in the size channel corresponding to the smaller critical supersaturation.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 42-43
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  • 85
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The chamber geometry and optical arrangement are described. The supersaturation range is given and consists of readings taken at five fixed points: 0.25%, 0.5%, 0.75%, 1.0%, and 1.25%. The detection system is described including light source, cameras, and photocell detectors. The temperature control and the calibration of the chamber are discussed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 26-27
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  • 86
    Publication Date: 2006-02-14
    Description: The NRL thermal gradient diffusion cloud chamber (TGDCC) consists of two plates 7.5 cm in diameter separated by 1.25 cm and covered with saturated filter paper. The cylindrical wall separating the plates is glass. The top plate is at room temperature and the bottom plate is cooled with a thermoelectric cooler. The temperature difference is measured with several sets of thermocouples. The CCN concentration was determined from the video recording. This procedure of averaging the maximum count obtained on several successive recordings at the same supersaturation results in concentrations which are somewhat higher than concentrations calculated from an average across the plateau.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 14-16
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  • 87
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    Publication Date: 2006-01-16
    Description: The selection of measurement systems for experiments conducted in the context of a space flight must be guided by the criteria applicable to any scientific study requiring objective measurements of physiological variables. Steps fundamental to the process of choosing the best instrumentation system are identified and the key factors in matching the operational characteristics of the instrumentation to its intended use are discussed. Special problems in obtaining data from nonhuman primates, whether restrained or unrestrained, are explored. Choices for data processing are evaluated as well as the use of prototype flight tests and simulations to assess future life science experiments for spacelab or payloads for the space shuttle biomedical scientific satellite.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Use of Nonhuman Primates in Space; p 225-243
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  • 88
    Publication Date: 2006-01-12
    Description: The infrared radiation from the earth in two spectral bands during both day and night portions of the orbit is measured. Pictures of cloud cover, three dimensional mappings of cloud cover, temperature mappings of clouds, land, and ocean surface, cirrus cloud content, atmospheric contamination, and relative humidity are provided.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Nimbus 7 User's Guide 247-262 (SEE N79-20148 11-12)
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  • 89
    Publication Date: 2006-01-12
    Description: Ocean momentum and energy transfer parameters on a nearly all weather operational basis are obtained and used. The winds, water vapor, liquid water content, temperature, and mean cloud droplet size are derived from low altitude parameters.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Nimbus 7 User's Guide; p 213-246
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  • 90
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    Publication Date: 2006-01-12
    Description: The CZCS is used to map chlorophyll concentration, sediment distribution, gelbstroffe concentration, and temperature of coastal waters and the open ocean. The data processing techniques used to enhance contrasts over the ocean and to remove the effect of the backscattered atmosphere are presented. The multi-channel scanning radiometer of CZCS is described. The content of water is determined primarily by the CZCS measurement.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center The Nimbus 7 User's Guide; p 19-32
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  • 91
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    Publication Date: 2006-02-14
    Description: Two instruments were used to size dry aerosols for the CCN experiments: the Naval Research Laboratory (NRL) instrument which uses an electrical mobility analyzer to separate the aerosol size fractions and a diffusion chamber to grow and count the particles and the University of Wyoming (WYO) aerosol monitoring system. Measurements from these two systems were usually found to be in agreement during the CCN Workshop. Two examples are presented to compare aerosol size distribution measurements of the two instruments: experiment 8 (monodisperse NaCl) and experiment 27 (polydisperse AgI). Differential (dN/dR) and cumulative plots are shown for both instruments for experiment 8 and experiment 27; also shown are Aitken particle measurements for comparison.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 106-107
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  • 92
    Publication Date: 2006-02-14
    Description: Nine CCN counters of the static diffusion (SDC) type were compared with one another and with continuous flow diffusion (CFD) chambers. The nine SDCs showed a considerable amount of variation, largely attributable to newness and/or lack of prior calibration of some units. The five more consistent instruments agreed quite well, to within at least 20 percent of the NRL mobility analyzer and to within 10 percent at 1 percent supersaturation. There was satisfactory agreement between the more reliable SDC and CFD chambers.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 57-63
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  • 93
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    In:  CASI
    Publication Date: 2006-02-14
    Description: The diffusion tube was designed to operate below about 0.25 percent of water supersaturation. It is simply a long tube lined on the inside with a damp chamois cloth, and heated isothermally to a few degrees centigrade above the incoming air. The diffusion coefficient for water vapor is slightly larger than that for heat, making it possible to supersaturate the airflow. This is the same principle by which transient supersaturations may occur in parallel plate cloud chambers. Only the diffusion of vapor and heat from the walls into the moving air are considered.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 37-39
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  • 94
    Publication Date: 2006-02-14
    Description: The chamber is a thermal gradient diffusion type with the upper plate at room temperature and the lower plate thermoelectrically cooled. The light from a 25W projector bulb is focused in a beam of approximations 1x3 mm in the central part of the chamber. The light scattered by drops is viewed in the forward direction (40 deg) by a microscope and a sensitive photodetector. Experiments were performed to relate the peak output from the photocell with the maximum number of drops in the beam recorded photographically. The microscope is used to check the calibration at low concentrations of CCN. The results of the experiments and the performance of the counter are reported.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Desert Research Inst. The Third Intern. Cloud Condensation Nuclei Workshop; p 33-34
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  • 95
    Publication Date: 2006-01-12
    Description: A water vapor radiometer (WVR) was developed that measures the atmospheric noise temperature at two different frequencies near 22 GHz. These noise temperature are used in empirical-theoretical equations that yield tropospheric range delay, in centimeters, through the atmosphere along the beam of the WVR. This range correction is then applied, as needed, to measurements concerning spacecraft range and to VLBI baseline determinations. The WVR design and calibration techniques are discussed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Deep Space Network; p 129-135
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  • 96
    Publication Date: 2006-01-16
    Description: The calibration coefficients of existing water vapor radiometers are dependent upon meteorology profiles. This is shown to be due mainly to incorrect frequency pairs. By properly selecting an optimum frequency pair, the dependency can be reduced to a relatively small amount which can be handily adjusted by surface measurement alone. Hence, a universal calibration equation is applicable to all environmental conditions - site, seasonal and diurnal variations. Optimum frequency pairs are systematically searched. Error analysis indicates that calibration for the water vapor phase delay accurate to less than 2 cm is possible at all elevation angles greater than 15 degrees.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Deep Space Network; p 67-81
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  • 97
    Publication Date: 2006-01-16
    Description: The Deep Space Network is in the process of fielding high-density digital instrumentation recorders for support of the Pioneer Venus 1978 entry experiment and other related tasks. It has long been obvious that these recorders would also serve well as the recording medium for very long base interferometry (VLBI) experiments with relatively weak radio sources, provided that a suitable correlation processor for these tape recordings could be established. The overall design and current status of a VLBI correlator designed to mate with these tape recorders are described.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: The Deep Space Network; p 90-98
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  • 98
    Publication Date: 2006-02-14
    Description: One of the principal advantages of electrography when compared to photography is the nearly linear relationship between source intensity versus resulting image density. This property allows for simplified and more accurate photometric calibration and permits a certain degree of extrapolation of the calibration to beyond the limits of the faintest photoelectric standard on an exposure. The desires to extract quantitative photometric information from electrographic (or photographic) negatives and to convert this information into a digital format for computer analysis or enhancement led to the widespread use of scanning microdensitometers to perform this A-to-D conversion. Therefore it is of vital importance to understand and, if practical, to avoid any nonlinearities which may be introduced during microdensitometry of electrographic emulsions.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 429-431
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  • 99
    Publication Date: 2006-02-14
    Description: The scanning of a direct plate with the automatic plate measuring machine which results in the automated selection and description of images is described. The selection of QSO candidates based on color-color diagrams constructed from the APM image data and the analysis of APM raster data for QSOs selected visually from objective prism plates are also discussed.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 417-418
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  • 100
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    Publication Date: 2006-02-14
    Description: The fundamental limitations of microdensitometers are reviewed and the design of a high microdensitometer described. The system will digitize to 16 bits in transmission at a speed of 100 kHz using a laser beam moving over the emulsion. Other features are automatic platen rotation and autofocus. The cost will be of order $200,000.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Goddard Space Flight Center Astron. Microdensitometry Conf.; p 333-341
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