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  • United States  (684)
  • Cells, Cultured
  • American Association for the Advancement of Science (AAAS)  (798)
  • Academic Press
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • Cornell University Press
  • University Press of Colorado
  • transcript Verlag
  • 2010-2014  (798)
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  • American Association for the Advancement of Science (AAAS)  (798)
  • Academic Press
  • American Association of Petroleum Geologists (AAPG)
  • Bonn: Institute of Labor Economics (IZA)
  • Cornell University Press
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):29. doi: 10.1126/science.344.6179.29.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700839" target="_blank"〉PubMed〈/a〉
    Keywords: *Administrative Personnel ; Biomedical Research/*economics/organization & administration ; Budgets ; Financing, Government ; Illinois ; National Institutes of Health (U.S.)/economics ; Research Support as Topic/*organization & administration ; United States ; Universities/*economics/organization & administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Mar 28;343(6178):1460-1. doi: 10.1126/science.343.6178.1460.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24675951" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Breast Neoplasms ; Female ; Humans ; *Patient Advocacy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):26. doi: 10.1126/science.344.6179.26.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700836" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Financing, Government ; Humans ; National Institutes of Health (U.S.)/*economics ; Parkinson Disease ; Research Personnel/*economics ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-08-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arita, Isao -- Francis, Donald -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1010. doi: 10.1126/science.345.6200.1010-a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Director Emeritus, National Hospital Organization, Kumamoto Medical Center, Kumamoto 861-8068, Japan. ; Executive Director, Global Solutions for Infectious Diseases, South San Francisco, CA 94080, USA. dfrancis@gsid.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170141" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Biological Warfare Agents ; *Disease Eradication ; Humans ; Risk Assessment ; Russia ; Smallpox/epidemiology/*prevention & control/virology ; United States ; *Variola virus ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):238. doi: 10.1126/science.343.6168.238.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436398" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Air Pollutants/*adverse effects/analysis ; Air Pollution/*adverse effects/prevention & control ; Ammonia/*adverse effects/analysis ; Animals ; Fertilizers/*adverse effects ; Health/*economics ; Heart Diseases/chemically induced ; Humans ; Livestock ; Models, Biological ; North Carolina ; Particulate Matter/*adverse effects/analysis ; Respiratory Tract Diseases/chemically induced ; United States ; United States Environmental Protection Agency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2014-05-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 May 16;344(6185):679. doi: 10.1126/science.344.6185.679.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24833367" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation/*standards ; Animals ; Biomedical Research/*standards ; Cells ; Female ; Male ; Mice ; National Institutes of Health (U.S.) ; Sex Factors ; United States ; X Chromosome ; Y Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clery, Daniel -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):290-1. doi: 10.1126/science.346.6207.290.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324365" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chemistry ; Mice ; Microscopy, Fluorescence/*methods ; *Nobel Prize ; Organelles/ultrastructure ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):6. doi: 10.1126/science.1250035.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385608" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Gross Domestic Product/trends ; Research/*economics/*trends ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):229. doi: 10.1126/science.1250475.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436391" target="_blank"〉PubMed〈/a〉
    Keywords: Disclosure/*standards ; *Guidelines as Topic ; Humans ; National Institute of Neurological Disorders and Stroke ; *Peer Review, Research ; Reproducibility of Results ; Translational Medical Research/standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):24-5. doi: 10.1126/science.344.6179.24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700835" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; Budgets ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic/trends ; United States ; Universities/economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):15. doi: 10.1126/science.343.6166.15.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385614" target="_blank"〉PubMed〈/a〉
    Keywords: Research Report ; Social Control, Formal ; United States ; *United States Environmental Protection Agency ; *Wetlands
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
    Publication Date: 2014-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):359. doi: 10.1126/science.343.6169.359.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458618" target="_blank"〉PubMed〈/a〉
    Keywords: Consumer Organizations ; *Embryonic Stem Cells ; Humans ; *Patents as Topic ; Stem Cell Research/*legislation & jurisprudence ; Supreme Court Decisions ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woolley, Mary -- Leshner, Alan I -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):791. doi: 10.1126/science.aaa2692.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mary Woolley is the president and chief executive officer of Research!America. mwoolley@researchamerica.org. ; Alan I. Leshner is the chief executive officer of the American Association for the Advancement of Science and executive publisher of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395507" target="_blank"〉PubMed〈/a〉
    Keywords: Earthquakes ; *Federal Government ; Floods ; Hemorrhagic Fever, Ebola ; Humans ; Petroleum Pollution ; Politics ; Science/*economics/*trends ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1441-2. doi: 10.1126/science.345.6203.1441.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237082" target="_blank"〉PubMed〈/a〉
    Keywords: Africa, Western/epidemiology ; Communicable Disease Control/*economics ; Disease Outbreaks/*prevention & control ; Drug Industry/*economics ; Drugs, Investigational/*economics ; Ebola Vaccines/*economics ; Hemorrhagic Fever, Ebola/*epidemiology/*prevention & control ; Humans ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):13. doi: 10.1126/science.346.6205.13. Epub 2014 Oct 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Donald Kennedy is president emeritus at Stanford University, Stanford, CA, and a former editor-in-chief of Science. kennedyd@stanford.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25278586" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/economics/*trends ; Research/economics/*trends ; United States ; United States Department of Agriculture
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):33. doi: 10.1126/science.344.6179.33.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700842" target="_blank"〉PubMed〈/a〉
    Keywords: BK Virus ; Biomedical Research/*economics ; Financing, Government ; National Institutes of Health (U.S.)/*economics ; *Research Support as Topic/economics/organization & administration ; Salaries and Fringe Benefits ; Travel/economics ; United States ; Virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhattacharjee, Yudhijit -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1306-9. doi: 10.1126/science.343.6177.1306.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653017" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; DNA, Intergenic/genetics ; Databases, Nucleic Acid ; *Genome, Human ; *Genomics ; History, 20th Century ; History, 21st Century ; Humans ; Molecular Sequence Annotation ; Mutation ; National Human Genome Research Institute (U.S.) ; Transcription Factors/metabolism ; Transcription, Genetic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):247-8. doi: 10.1126/science.345.6194.247.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035464" target="_blank"〉PubMed〈/a〉
    Keywords: *Anthrax ; Biohazard Release/*prevention & control ; Centers for Disease Control and Prevention (U.S.) ; Humans ; *Influenza, Human ; *Laboratories ; National Institutes of Health (U.S.) ; Public Health ; *Safety ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kerr, Richard A -- New York, N.Y. -- Science. 2014 Apr 11;344(6180):138-9. doi: 10.1126/science.344.6180.138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24723588" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Research Personnel/*economics ; *Solar System ; Space Flight/*economics ; United States ; United States National Aeronautics and Space Administration/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bloom, Barry R -- Marcuse, Edgar -- Mnookin, Seth -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):339. doi: 10.1126/science.1254834.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Barry R. Bloom is a professor at the Harvard School of Public Health, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763557" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; Disease Outbreaks/*prevention & control ; *Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Parents/*psychology ; *Research ; Research Design ; *Treatment Refusal/psychology ; United States ; *Vaccination/psychology/utilization
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 21
    Publication Date: 2014-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collins, Francis S -- Wilder, Elizabeth L -- Zerhouni, Elias -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):274-6. doi: 10.1126/science.1255860. Epub 2014 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. francis.collins@nih.gov. ; National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035478" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Financial Management ; Humans ; National Institutes of Health (U.S.)/*economics ; United States
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 22
    Publication Date: 2014-08-30
    Description: Cells use actomyosin contractility to move through three-dimensional (3D) extracellular matrices. Contractility affects the type of protrusions cells use to migrate in 3D, but the mechanisms are unclear. In this work, we found that contractility generated high-pressure lobopodial protrusions in human cells migrating in a 3D matrix. In these cells, the nucleus physically divided the cytoplasm into forward and rear compartments. Actomyosin contractility with the nucleoskeleton-intermediate filament linker protein nesprin-3 pulled the nucleus forward and pressurized the front of the cell. Reducing expression of nesprin-3 decreased and equalized the intracellular pressure. Thus, the nucleus can act as a piston that physically compartmentalizes the cytoplasm and increases the hydrostatic pressure between the nucleus and the leading edge of the cell to drive lamellipodia-independent 3D cell migration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petrie, Ryan J -- Koo, Hyun -- Yamada, Kenneth M -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1062-5. doi: 10.1126/science.1256965.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA. petrier@mail.nih.gov kyamada@mail.nih.gov. ; Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4370, USA. Center for Oral Biology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104-6030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170155" target="_blank"〉PubMed〈/a〉
    Keywords: Actomyosin/physiology ; Cell Movement/*physiology ; Cell Nucleus/*physiology ; Cells, Cultured ; Cytoplasm/physiology ; Extracellular Matrix/*physiology/ultrastructure ; Fibroblasts/*physiology ; Humans ; Hydrostatic Pressure ; Microfilament Proteins ; Pseudopodia/*physiology ; Vimentin/metabolism
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-09-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hand, Eric -- New York, N.Y. -- Science. 2014 Sep 12;345(6202):1233. doi: 10.1126/science.345.6202.1233.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25214586" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/analysis/*standards ; Air Pollution/analysis/*legislation & jurisprudence ; China ; Climate Change ; Ozone/analysis/*standards ; United States ; United States Environmental Protection Agency/economics/legislation & ; jurisprudence ; Wind
    Print ISSN: 0036-8075
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1298. doi: 10.1126/science.343.6177.1298-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653013" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Financing, Government ; *Politics ; Public Policy ; *Research Support as Topic ; United States ; United States Government Agencies/economics/*legislation & ; jurisprudence/organization & administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 23;344(6186):836-7. doi: 10.1126/science.344.6186.836.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855257" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Policy Making ; Social Mobility/*statistics & numerical data/*trends ; Taxes ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1298-9. doi: 10.1126/science.343.6177.1298-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653012" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; *Politics ; Public Policy ; *Research Support as Topic ; United States ; United States Government Agencies/*legislation & jurisprudence/organization & ; administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):830. doi: 10.1126/science.343.6173.830.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558139" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; *Federal Government ; Research/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: This Review presents basic facts regarding the long-run evolution of income and wealth inequality in Europe and the United States. Income and wealth inequality was very high a century ago, particularly in Europe, but dropped dramatically in the first half of the 20th century. Income inequality has surged back in the United States since the 1970s so that the United States is much more unequal than Europe today. We discuss possible interpretations and lessons for the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piketty, Thomas -- Saez, Emmanuel -- New York, N.Y. -- Science. 2014 May 23;344(6186):838-43. doi: 10.1126/science.1251936.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, Paris School of Economics, Paris, France. thomas.piketty@psemail.eu. ; Department of Economics, University of California at Berkeley, Berkeley, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855258" target="_blank"〉PubMed〈/a〉
    Keywords: *Economic Development ; Europe ; History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Income/history/*statistics & numerical data/*trends ; Socioeconomic Factors/history ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):357. doi: 10.1126/science.343.6169.357.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458616" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics ; *Budgets ; *Financing, Government ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):596-8. doi: 10.1126/science.343.6171.596.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503830" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/*trends ; Clinical Trials as Topic/economics/trends ; Financing, Organized ; Humans ; *National Institutes of Health (U.S.) ; *Peer Review, Research ; Publications/*statistics & numerical data ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):237. doi: 10.1126/science.343.6168.237.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436397" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/education ; *Budgets ; Physics/economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):125-6. doi: 10.1126/science.343.6167.125.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408407" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Curriculum ; Science/*education ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cordova, France -- Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 30;344(6187):959-61. doi: 10.1126/science.344.6187.959.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876473" target="_blank"〉PubMed〈/a〉
    Keywords: *Foundations ; Science/*economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-07-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carney, Joanne Padron -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):243. doi: 10.1126/science.1258492.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Joanne Padron Carney is the director of government relations at AAAS, Washington, DC. jcarney@aaas.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035462" target="_blank"〉PubMed〈/a〉
    Keywords: *Communication ; *Federal Government ; Policy ; *Policy Making ; *Science ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carswell, Cally -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):154-6. doi: 10.1126/science.346.6206.154.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cally Carswell is a freelance science and environment writer in Santa Fe.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Pinus/*parasitology ; Plant Bark/*parasitology ; Trees/*parasitology ; United States ; *Weevils
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  • 36
    Publication Date: 2014-11-15
    Description: Lightning plays an important role in atmospheric chemistry and in the initiation of wildfires, but the impact of global warming on lightning rates is poorly constrained. Here we propose that the lightning flash rate is proportional to the convective available potential energy (CAPE) times the precipitation rate. Using observations, the product of CAPE and precipitation explains 77% of the variance in the time series of total cloud-to-ground lightning flashes over the contiguous United States (CONUS). Storms convert CAPE times precipitated water mass to discharged lightning energy with an efficiency of 1%. When this proxy is applied to 11 climate models, CONUS lightning strikes are predicted to increase 12 +/- 5% per degree Celsius of global warming and about 50% over this century.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romps, David M -- Seeley, Jacob T -- Vollaro, David -- Molinari, John -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):851-4. doi: 10.1126/science.1259100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth and Planetary Science, University of California, Berkeley, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. romps@berkeley.edu. ; Department of Earth and Planetary Science, University of California, Berkeley, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. ; Department of Atmospheric and Environmental Sciences, State University of New York at Albany, Albany, NY, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395536" target="_blank"〉PubMed〈/a〉
    Keywords: *Convection ; *Global Warming ; *Lightning ; United States
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    Publication Date: 2014-11-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Francis S -- Heimer, Hakon -- Giedd, Jay N -- Lein, Edward S -- Sestan, Nenad -- Weinberger, Daniel R -- Casey, B J -- New York, N.Y. -- Science. 2014 Oct 31;346(6209):547-9. doi: 10.1126/science.1260497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. ; Schizophrenia Research Forum, Brain and Behavior Research Foundation, Providence, RI 02906, USA. Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. ; Division of Child and Adolescent Psychiatry, University of California, San Diego, CA 92123, USA. ; Allen Institute for Brain Science, Seattle, WA 98103, USA. ; Department of Neurobiology and Psychiatry, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA. ; Lieber Institute for Brain Development, Baltimore, MD 21205, USA. Department of Psychiatry, Neurology, Neuroscience, and the Institute of Genomic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 20215, USA. ; Sackler Institute, Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA. bjc2002@med.cornell.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25359951" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Adolescent Behavior ; *Adolescent Development ; Age of Onset ; Brain/*growth & development/physiology ; *Early Medical Intervention ; Humans ; Mental Disorders/diagnosis/epidemiology/*prevention & control ; *Mental Health ; National Institutes of Health (U.S.)/economics ; Neuroimaging ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazer, David -- Kennedy, Ryan -- King, Gary -- Vespignani, Alessandro -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1203-5. doi: 10.1126/science.1248506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lazer Laboratory, Northeastern University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626916" target="_blank"〉PubMed〈/a〉
    Keywords: Centers for Disease Control and Prevention (U.S.) ; Data Collection/statistics & numerical data ; Data Interpretation, Statistical ; *Disease Outbreaks ; Humans ; Influenza, Human/*epidemiology ; Office Visits/statistics & numerical data/*trends ; Prognosis ; Social Media/*utilization ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
    Publication Date: 2014-03-01
    Description: Understanding the spatial organization of gene expression with single-nucleotide resolution requires localizing the sequences of expressed RNA transcripts within a cell in situ. Here, we describe fluorescent in situ RNA sequencing (FISSEQ), in which stably cross-linked complementary DNA (cDNA) amplicons are sequenced within a biological sample. Using 30-base reads from 8102 genes in situ, we examined RNA expression and localization in human primary fibroblasts with a simulated wound-healing assay. FISSEQ is compatible with tissue sections and whole-mount embryos and reduces the limitations of optical resolution and noisy signals on single-molecule detection. Our platform enables massively parallel detection of genetic elements, including gene transcripts and molecular barcodes, and can be used to investigate cellular phenotype, gene regulation, and environment in situ.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140943/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140943/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Je Hyuk -- Daugharthy, Evan R -- Scheiman, Jonathan -- Kalhor, Reza -- Yang, Joyce L -- Ferrante, Thomas C -- Terry, Richard -- Jeanty, Sauveur S F -- Li, Chao -- Amamoto, Ryoji -- Peters, Derek T -- Turczyk, Brian M -- Marblestone, Adam H -- Inverso, Samuel A -- Bernard, Amy -- Mali, Prashant -- Rios, Xavier -- Aach, John -- Church, George M -- GM080177/GM/NIGMS NIH HHS/ -- MH098977/MH/NIMH NIH HHS/ -- P50 HG005550/HG/NHGRI NIH HHS/ -- RC2 HL102815/HL/NHLBI NIH HHS/ -- RC2HL102815/HL/NHLBI NIH HHS/ -- T32 GM007753/GM/NIGMS NIH HHS/ -- T32 GM080177/GM/NIGMS NIH HHS/ -- U01 MH098977/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1360-3. doi: 10.1126/science.1250212. Epub 2014 Feb 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wyss Institute, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24578530" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Cell Line ; Cells, Cultured ; DNA, Complementary ; Fluorescence ; Gene Expression Profiling/*methods ; Humans ; Induced Pluripotent Stem Cells ; RNA, Messenger/genetics/metabolism ; Sequence Analysis, RNA/*methods ; Single-Cell Analysis ; Transcription Initiation Site ; *Transcriptome ; Wound Healing
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Publication Date: 2014-06-21
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉H3Africa Consortium -- Rotimi, Charles -- Abayomi, Akin -- Abimiku, Alash'le -- Adabayeri, Victoria May -- Adebamowo, Clement -- Adebiyi, Ezekiel -- Ademola, Adebowale D -- Adeyemo, Adebowale -- Adu, Dwomoa -- Affolabi, Dissou -- Agongo, Godfred -- Ajayi, Samuel -- Akarolo-Anthony, Sally -- Akinyemi, Rufus -- Akpalu, Albert -- Alberts, Marianne -- Alonso Betancourt, Orlando -- Alzohairy, Ahmed Mansour -- Ameni, Gobena -- Amodu, Olukemi -- Anabwani, Gabriel -- Andersen, Kristian -- Arogundade, Fatiu -- Arulogun, Oyedunni -- Asogun, Danny -- Bakare, Rasheed -- Balde, Naby -- Baniecki, Mary Lynn -- Beiswanger, Christine -- Benkahla, Alia -- Bethke, Lara -- Boehnke, Micheal -- Boima, Vincent -- Brandful, James -- Brooks, Andrew I -- Brosius, Frank C -- Brown, Chester -- Bucheton, Bruno -- Burke, David T -- Burnett, Barrington G -- Carrington-Lawrence, Stacy -- Carstens, Nadia -- Chisi, John -- Christoffels, Alan -- Cooper, Richard -- Cordell, Heather -- Crowther, Nigel -- Croxton, Talishiea -- de Vries, Jantina -- Derr, Leslie -- Donkor, Peter -- Doumbia, Seydou -- Duncanson, Audrey -- Ekem, Ivy -- El Sayed, Ahmed -- Engel, Mark E -- Enyaru, John C K -- Everett, Dean -- Fadlelmola, Faisal M -- Fakunle, Eyitayo -- Fischbeck, Kenneth H -- Fischer, Anne -- Folarin, Onikepe -- Gamieldien, Junaid -- Garry, Robert F -- Gaseitsiwe, Simani -- Gbadegesin, Rasheed -- Ghansah, Anita -- Giovanni, Maria -- Goesbeck, Parham -- Gomez-Olive, F Xavier -- Grant, Donald S -- Grewal, Ravnit -- Guyer, Mark -- Hanchard, Neil A -- Happi, Christian T -- Hazelhurst, Scott -- Hennig, Branwen J -- Hertz-, Christiane -- Fowler -- Hide, Winston -- Hilderbrandt, Friedhelm -- Hugo-Hamman, Christopher -- Ibrahim, Muntaser E -- James, Regina -- Jaufeerally-Fakim, Yasmina -- Jenkins, Carolyn -- Jentsch, Ute -- Jiang, Pan-Pan -- Joloba, Moses -- Jongeneel, Victor -- Joubert, Fourie -- Kader, Mukthar -- Kahn, Kathleen -- Kaleebu, Pontiano -- Kapiga, Saidi H -- Kassim, Samar Kamal -- Kasvosve, Ishmael -- Kayondo, Jonathan -- Keavney, Bernard -- Kekitiinwa, Adeodata -- Khan, Sheik Humarr -- Kimmel, Paul -- King, Mary-Claire -- Kleta, Robert -- Koffi, Mathurin -- Kopp, Jeffrey -- Kretzler, Matthias -- Kumuthini, Judit -- Kyobe, Samuel -- Kyobutungi, Catherine -- Lackland, Daniel T -- Lacourciere, Karen A -- Landoure, Guida -- Lawlor, Rita -- Lehner, Thomas -- Lesosky, Maia -- Levitt, Naomi -- Littler, Katherine -- Lombard, Zane -- Loring, Jeanne F -- Lyantagaye, Sylvester -- Macleod, Annette -- Madden, Ebony B -- Mahomva, Chengetai R -- Makani, Julie -- Mamven, Manmak -- Marape, Marape -- Mardon, Graeme -- Marshall, Patricia -- Martin, Darren P -- Masiga, Daniel -- Mason, Robin -- Mate-Kole, Michael -- Matovu, Enock -- Mayige, Mary -- Mayosi, Bongani M -- Mbanya, Jean Claude -- McCurdy, Sheryl A -- McCarthy, Mark I -- McIlleron, Helen -- Mc'Ligeyo, S O -- Merle, Corrine -- Mocumbi, Ana Olga -- Mondo, Charles -- Moran, John V -- Motala, Ayesha -- Moxey-Mims, Marva -- Mpoloka, Wata Sununguko -- Msefula, Chisomo L -- Mthiyane, Thuli -- Mulder, Nicola -- Mulugeta, Gebregziab her -- Mumba, Dieuodonne -- Musuku, John -- Nagdee, Mo -- Nash, Oyekanmi -- Ndiaye, Daouda -- Nguyen, Anh Quynh -- Nicol, Mark -- Nkomazana, Oathokwa -- Norris, Shane -- Nsangi, Betty -- Nyarko, Alexander -- Nyirenda, Moffat -- Obe, Eileen -- Obiakor, Reginald -- Oduro, Abraham -- Ofori-Acquah, Solomon F -- Ogah, Okechukwu -- Ogendo, Stephen -- Ohene-Frempong, Kwaku -- Ojo, Akinlolu -- Olanrewaju, Timothy -- Oli, John -- Osafo, Charlotte -- Ouwe Missi Oukem-Boyer, Odile -- Ovbiagele, Bruce -- Owen, Andrew -- Owolabi, Mayowa Ojo -- Owolabi, Lukman -- Owusu-Dabo, Ellis -- Pare, Guillaume -- Parekh, Rulan -- Patterton, Hugh G -- Penno, Margaret B -- Peterson, Jane -- Pieper, Rembert -- Plange-Rhule, Jacob -- Pollak, Martin -- Puzak, Julia -- Ramesar, Rajkumar S -- Ramsay, Michele -- Rasooly, Rebekah -- Reddy, Shiksha -- Sabeti, Pardis C -- Sagoe, Kwamena -- Salako, Tunde -- Samassekou, Oumar -- Sandhu, Manjinder S -- Sankoh, Osman -- Sarfo, Fred Stephen -- Sarr, Marie -- Shaboodien, Gasnat -- Sidibe, Issa -- Simo, Gustave -- Simuunza, Martin -- Smeeth, Liam -- Sobngwi, Eugene -- Soodyall, Himla -- Sorgho, Hermann -- Sow Bah, Oumou -- Srinivasan, Sudha -- Stein, Dan J -- Susser, Ezra S -- Swanepoel, Carmen -- Tangwa, Godfred -- Tareila, Andrew -- Tastan Bishop, Ozlem -- Tayo, Bamidele -- Tiffin, Nicki -- Tinto, Halidou -- Tobin, Ekaete -- Tollman, Stephen Meir -- Traore, Mahamadou -- Treadwell, Marsha J -- Troyer, Jennifer -- Tsimako-Johnstone, Masego -- Tukei, Vincent -- Ulasi, Ifeoma -- Ulenga, Nzovu -- van Rooyen, Beverley -- Wachinou, Ablo Prudence -- Waddy, Salina P -- Wade, Alisha -- Wayengera, Misaki -- Whitworth, James -- Wideroff, Louise -- Winkler, Cheryl A -- Winnicki, Sarah -- Wonkam, Ambroise -- Yewondwos, Mengistu -- sen, Tadase -- Yozwiak, Nathan -- Zar, Heather -- 085349/Wellcome Trust/United Kingdom -- 095009/Wellcome Trust/United Kingdom -- 095201/Wellcome Trust/United Kingdom -- 098504/Wellcome Trust/United Kingdom -- 104111/Wellcome Trust/United Kingdom -- MC_U123292700/Medical Research Council/United Kingdom -- P20 MD006899/MD/NIMHD NIH HHS/ -- R01 AI104621/AI/NIAID NIH HHS/ -- RG/08/012/25941/British Heart Foundation/United Kingdom -- U01 HG007044/HG/NHGRI NIH HHS/ -- U41 HG006941/HG/NHGRI NIH HHS/ -- U54 AI110398/AI/NIAID NIH HHS/ -- U54 HG006938/HG/NHGRI NIH HHS/ -- U54 HG006939/HG/NHGRI NIH HHS/ -- U54 HG007479/HG/NHGRI NIH HHS/ -- UH2 HG007051/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948725" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Disease/*genetics ; England ; Genetics, Medical/trends ; Genome-Wide Association Study/*trends ; Genomics/*trends ; Health ; Humans ; National Institutes of Health (U.S.) ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, Thomas H -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1208-10. doi: 10.1126/science.1248080.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Hastings Center, Garrison, New York, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626919" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Embryo, Mammalian ; Guidelines as Topic ; Humans ; Insemination, Artificial ; Mitochondria/*genetics ; Mitochondrial Diseases/*genetics/*prevention & control ; Ovum ; Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence ; United States ; United States Food and Drug Administration
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Underwood, Emily -- New York, N.Y. -- Science. 2014 May 23;344(6186):820-1. doi: 10.1126/science.344.6186.820.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855250" target="_blank"〉PubMed〈/a〉
    Keywords: Developed Countries/*economics/statistics & numerical data ; Developing Countries/*economics/statistics & numerical data ; Income/*statistics & numerical data ; Socioeconomic Factors ; United States
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  • 43
    Publication Date: 2014-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carmona, Richard -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):589. doi: 10.1126/science.343.6171.589.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24503826" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Inhalation ; Adult ; Child ; *Device Approval ; Humans ; Nicotine/*administration & dosage ; Smoking/*epidemiology/*prevention & control ; United States ; United States Food and Drug Administration
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  • 44
    Publication Date: 2014-01-25
    Description: The physical manifestation of learning and memory formation in the brain can be expressed by strengthening or weakening of synaptic connections through morphological changes. Local actin remodeling underlies some forms of plasticity and may be facilitated by local beta-actin synthesis, but dynamic information is lacking. In this work, we use single-molecule in situ hybridization to demonstrate that dendritic beta-actin messenger RNA (mRNA) and ribosomes are in a masked, neuron-specific form. Chemically induced long-term potentiation prompts transient mRNA unmasking, which depends on factors active during synaptic activity. Ribosomes and single beta-actin mRNA motility increase after stimulation, indicative of release from complexes. Hence, the single-molecule assays we developed allow for the quantification of activity-induced unmasking and availability for active translation. Further, our work demonstrates that beta-actin mRNA and ribosomes are in a masked state that is alleviated by stimulation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121734/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121734/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buxbaum, Adina R -- Wu, Bin -- Singer, Robert H -- GM84364/GM/NIGMS NIH HHS/ -- NS083085-19/NS/NINDS NIH HHS/ -- R01 NS083085/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):419-22. doi: 10.1126/science.1242939.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458642" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*biosynthesis/genetics ; Animals ; Cells, Cultured ; Dendrites/metabolism ; In Situ Hybridization, Fluorescence/methods ; Long-Term Potentiation/drug effects/*physiology ; Memory/physiology ; Mice ; Mice, Transgenic ; Neuronal Plasticity/drug effects/physiology ; Neurons/*metabolism ; *Protein Biosynthesis ; RNA, Messenger/analysis/*biosynthesis ; RNA, Ribosomal/metabolism ; Ribosomes/*metabolism ; Synapses/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-08-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, Nicholas Z -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):873-4. doi: 10.1126/science.1253506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics and Environmental Studies Program, Middlebury College, Middlebury, VT 05753 USA. Faculty Research Fellow, National Bureau of Economic Research, Cambridge, MA 02138 USA. nmuller@middlebury.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146270" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollution/*economics ; Environment ; Greenhouse Effect/*economics ; Gross Domestic Product/*trends ; United States
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  • 46
    Publication Date: 2014-08-12
    Description: Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans, SMN2, produces low, insufficient levels of functional SMN protein due to alternative splicing that truncates the transcript. The decreased levels of SMN protein lead to progressive neuromuscular degeneration and high rates of mortality. Through chemical screening and optimization, we identified orally available small molecules that shift the balance of SMN2 splicing toward the production of full-length SMN2 messenger RNA with high selectivity. Administration of these compounds to Delta7 mice, a model of severe SMA, led to an increase in SMN protein levels, improvement of motor function, and protection of the neuromuscular circuit. These compounds also extended the life span of the mice. Selective SMN2 splicing modifiers may have therapeutic potential for patients with SMA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Naryshkin, Nikolai A -- Weetall, Marla -- Dakka, Amal -- Narasimhan, Jana -- Zhao, Xin -- Feng, Zhihua -- Ling, Karen K Y -- Karp, Gary M -- Qi, Hongyan -- Woll, Matthew G -- Chen, Guangming -- Zhang, Nanjing -- Gabbeta, Vijayalakshmi -- Vazirani, Priya -- Bhattacharyya, Anuradha -- Furia, Bansri -- Risher, Nicole -- Sheedy, Josephine -- Kong, Ronald -- Ma, Jiyuan -- Turpoff, Anthony -- Lee, Chang-Sun -- Zhang, Xiaoyan -- Moon, Young-Choon -- Trifillis, Panayiota -- Welch, Ellen M -- Colacino, Joseph M -- Babiak, John -- Almstead, Neil G -- Peltz, Stuart W -- Eng, Loren A -- Chen, Karen S -- Mull, Jesse L -- Lynes, Maureen S -- Rubin, Lee L -- Fontoura, Paulo -- Santarelli, Luca -- Haehnke, Daniel -- McCarthy, Kathleen D -- Schmucki, Roland -- Ebeling, Martin -- Sivaramakrishnan, Manaswini -- Ko, Chien-Ping -- Paushkin, Sergey V -- Ratni, Hasane -- Gerlach, Irene -- Ghosh, Anirvan -- Metzger, Friedrich -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):688-93. doi: 10.1126/science.1250127.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA. ; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. ; PTC Therapeutics, 100 Corporate Court, South Plainfield, NJ 07080, USA. friedrich.metzger@roche.com speltz@ptcbio.com. ; SMA Foundation, 888 Seventh Avenue, Suite 400, New York, NY 10019, USA. ; Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. ; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland. ; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland. friedrich.metzger@roche.com speltz@ptcbio.com.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104390" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Alternative Splicing/*drug effects ; Animals ; Cells, Cultured ; Coumarins/*administration & dosage/chemistry ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Humans ; Isocoumarins/*administration & dosage/chemistry ; Longevity/*drug effects ; Mice ; Muscular Atrophy, Spinal/*drug therapy/genetics/metabolism ; Pyrimidinones/*administration & dosage/chemistry ; RNA, Messenger/genetics ; Sequence Deletion ; Small Molecule Libraries/*administration & dosage/chemistry ; Survival of Motor Neuron 2 Protein/*genetics/metabolism
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  • 47
    Publication Date: 2014-04-05
    Description: Adrenal Cushing's syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders. We performed whole-exome sequencing of 49 blood-tumor pairs and RNA sequencing of 44 tumors from cortisol-producing adrenocortical adenomas (ACAs), adrenocorticotropic hormone-independent macronodular adrenocortical hyperplasias (AIMAHs), and adrenocortical oncocytomas (ADOs). We identified a hotspot in the PRKACA gene with a L205R mutation in 69.2% (27 out of 39) of ACAs and validated in 65.5% of a total of 87 ACAs. Our data revealed that the activating L205R mutation, which locates in the P+1 loop of the protein kinase A (PKA) catalytic subunit, promoted PKA substrate phosphorylation and target gene expression. Moreover, we discovered the recurrently mutated gene DOT1L in AIMAHs and CLASP2 in ADOs. Collectively, these data highlight potentially functional mutated genes in adrenal Cushing's syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cao, Yanan -- He, Minghui -- Gao, Zhibo -- Peng, Ying -- Li, Yanli -- Li, Lin -- Zhou, Weiwei -- Li, Xiangchun -- Zhong, Xu -- Lei, Yiming -- Su, Tingwei -- Wang, Hang -- Jiang, Yiran -- Yang, Lin -- Wei, Wei -- Yang, Xu -- Jiang, Xiuli -- Liu, Li -- He, Juan -- Ye, Junna -- Wei, Qing -- Li, Yingrui -- Wang, Weiqing -- Wang, Jun -- Ning, Guang -- New York, N.Y. -- Science. 2014 May 23;344(6186):913-7. doi: 10.1126/science.1249480. Epub 2014 Apr 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. ; BGI-Shanghai, BGI-Shenzhen, Shenzhen, China. ; Department of Pathology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. ; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. guangning@medmail.com.cn wangj@genomics.org.cn wqingw@hotmail.com. ; BGI-Shanghai, BGI-Shenzhen, Shenzhen, China. Department of Biology, University of Copenhagen, Copenhagen, Denmark. King Abdulaziz University, Jeddah, Saudi Arabia. Macau University of Science and Technology, Macau, China. Department of Medicine, University of Hong Kong, Hong Kong. guangning@medmail.com.cn wangj@genomics.org.cn wqingw@hotmail.com. ; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), and Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. guangning@medmail.com.cn wangj@genomics.org.cn wqingw@hotmail.com.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700472" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Neoplasms/*genetics/*metabolism ; Adrenocortical Adenoma/*genetics/*metabolism ; Amino Acid Substitution ; Arginine/genetics ; Catalytic Domain/genetics ; Cells, Cultured ; Cushing Syndrome/*genetics ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/chemistry/*genetics ; Glucocorticoids/metabolism ; Humans ; Hydrocortisone/*metabolism ; Leucine/genetics ; Methyltransferases/genetics ; Microtubule-Associated Proteins/genetics ; Mutation
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):404. doi: 10.1126/science.346.6208.404.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342775" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronavirus ; Federal Government ; Humans ; Influenza A Virus, H5N1 Subtype ; Mice ; Risk ; Security Measures ; United States ; Virology/*economics/*trends ; Virus Diseases/*prevention & control/*transmission
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1115. doi: 10.1126/science.345.6201.1115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25190776" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research ; Federal Government ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza A Virus, H7N9 Subtype/*pathogenicity ; Risk Management ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):150-1. doi: 10.1126/science.346.6206.150.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301595" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Biomedical Research/*economics ; Humans ; National Institutes of Health (U.S.)/economics/legislation & jurisprudence ; Research Personnel/statistics & numerical data ; Research Support as Topic/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1464-7. doi: 10.1126/science.344.6191.1464.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970074" target="_blank"〉PubMed〈/a〉
    Keywords: Climate Change ; Ecosystem ; Environmental Pollution ; *Natural Gas/economics/toxicity ; *Oil and Gas Fields ; United States ; Water Quality
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Jul 25;345(6195):366-7. doi: 10.1126/science.345.6195.366.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25061183" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; Financing, Organized ; Humans ; National Institute of General Medical Sciences (U.S.)/economics ; National Institutes of Health (U.S.)/*economics ; Research Personnel/*economics ; United States
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  • 53
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1186-7. doi: 10.1126/science.343.6176.1186.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626907" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Federal Government ; Science/*economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Jun 20;344(6190):1327. doi: 10.1126/science.344.6190.1327.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24948712" target="_blank"〉PubMed〈/a〉
    Keywords: Child ; *Health Status ; Humans ; National Institute of Child Health and Human Development (U.S.)/*trends ; *Patient Selection ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):13. doi: 10.1126/science.343.6166.13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385612" target="_blank"〉PubMed〈/a〉
    Keywords: Commerce/*economics ; Federal Government ; Investments/*legislation & jurisprudence ; Research/*economics ; Tax Exemption/*legislation & jurisprudence ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):350. doi: 10.1126/science.344.6182.350.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763564" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Financing, Government ; *National Institutes of Health (U.S.)/economics/organization & administration ; Peer Review, Research ; *Research Support as Topic ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1070-1. doi: 10.1126/science.344.6188.1070.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24904132" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*standards ; Air Pollution/*prevention & control ; Carbon Dioxide/*standards ; Global Warming/*prevention & control ; Greenhouse Effect/*prevention & control ; United States ; United States Environmental Protection Agency/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-08-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, David -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):988. doi: 10.1126/science.345.6200.988.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170127" target="_blank"〉PubMed〈/a〉
    Keywords: *Accreditation ; Animal Welfare/*standards ; Animals ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stokstad, Erik -- New York, N.Y. -- Science. 2014 Mar 21;343(6177):1301. doi: 10.1126/science.343.6177.1301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24653015" target="_blank"〉PubMed〈/a〉
    Keywords: Colorado ; *Ecosystem ; *Floods ; Groundwater ; Mexico ; *Rivers ; Salinity ; Trees/*growth & development ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gronewold, Andrew D -- Stow, Craig A -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1084-5. doi: 10.1126/science.1249978.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Oceanic and Atmospheric Administration (NOAA), Great Lakes Environmental Research Laboratory (GLERL), Ann Arbor, MI, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24604186" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; *Climate Change ; *Environmental Monitoring ; *Lakes ; United States ; *Water Resources
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Publication Date: 2014-03-08
    Description: River networks evolve as migrating drainage divides reshape river basins and change network topology by capture of river channels. We demonstrate that a characteristic metric of river network geometry gauges the horizontal motion of drainage divides. Assessing this metric throughout a landscape maps the dynamic states of entire river networks, revealing diverse conditions: Drainage divides in the Loess Plateau of China appear stationary; the young topography of Taiwan has migrating divides driving adjustment of major basins; and rivers draining the ancient landscape of the southeastern United States are reorganizing in response to escarpment retreat and coastal advance. The ability to measure the dynamic reorganization of river basins presents opportunities to examine landscape-scale interactions among tectonics, erosion, and ecology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willett, Sean D -- McCoy, Scott W -- Perron, J Taylor -- Goren, Liran -- Chen, Chia-Yu -- New York, N.Y. -- Science. 2014 Mar 7;343(6175):1248765. doi: 10.1126/science.1248765.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Geological Institute, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24604204" target="_blank"〉PubMed〈/a〉
    Keywords: Climate ; Geologic Sediments ; Models, Theoretical ; *Rivers ; Soil ; Taiwan ; United States ; *Water Movements
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin-Frankel, Jennifer -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):28-9. doi: 10.1126/science.344.6179.28.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700838" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*economics ; Brain/growth & development ; Faculty ; Financing, Government ; National Institutes of Health (U.S.)/economics ; *Research Personnel/economics/education ; *Research Support as Topic ; United States ; Zebrafish
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):815. doi: 10.1126/science.1251932.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt is Editor-in-Chief of Science.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558130" target="_blank"〉PubMed〈/a〉
    Keywords: Canada ; *Conservation of Natural Resources ; *Extraction and Processing Industry ; *Fossil Fuels ; Petroleum ; *Renewable Energy ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Publication Date: 2014-10-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kalokairinou, Louiza -- Howard, Heidi Carmen -- Borry, Pascal -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):296-8. doi: 10.1126/science.1256396. Epub 2014 Oct 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Public Health and Primary Care, University of Leuven, B-3000 Leuven, Belgium. ; Center for Research Ethics and Bioethics, Uppsala University, SE-751 22 Uppsala, Sweden. ; Department of Public Health and Primary Care, University of Leuven, B-3000 Leuven, Belgium. pascal.borry@med.kuleuven.be.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324369" target="_blank"〉PubMed〈/a〉
    Keywords: *Consumer Advocacy ; European Union ; Genetic Privacy/*legislation & jurisprudence ; Genetic Services/*legislation & jurisprudence ; Genetic Testing ; Genomics/*legislation & jurisprudence ; *Guidelines as Topic ; Humans ; Risk Assessment/classification ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, John Edward -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1207. doi: 10.1126/science.1256929.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉John Edward Porter is a former U.S. congressman, a partner in the law firm of Hogan Lovells, and chair of Research!America.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24925988" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/*economics/*trends ; Budgets ; Capital Financing/*organization & administration/trends ; Humans ; *Information Dissemination ; National Institutes of Health (U.S.)/*economics ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glaeser, Edward L -- Shleifer, Andrei -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1233. doi: 10.1126/science.1256540.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Harvard University, Boston, MA, USA. ; Harvard University, Boston, MA, USA. shleifer@fas.harvard.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926006" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavior ; Economics/*history ; History, 20th Century ; History, 21st Century ; Humans ; Investments/history ; Nobel Prize ; Racism/history/psychology ; Sociology/*history ; Training Support/history ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 May 23;344(6186):826-7. doi: 10.1126/science.344.6186.826.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855253" target="_blank"〉PubMed〈/a〉
    Keywords: *Capitalism ; Databases, Factual ; France ; History, 18th Century ; History, 21st Century ; Income/history/statistics & numerical data/*trends ; Income Tax/history/statistics & numerical data/*trends ; Socioeconomic Factors/history ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, Eliot -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):27. doi: 10.1126/science.344.6179.27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700837" target="_blank"〉PubMed〈/a〉
    Keywords: Biochemistry ; Biomedical Research/*economics ; Financing, Government ; National Institutes of Health (U.S.)/economics ; Peer Review, Research ; Research Personnel/*economics ; *Research Support as Topic ; United States ; United States Government Agencies/economics
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernstein, Rachel -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):798. doi: 10.1126/science.346.6211.798.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395513" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Engineering/manpower ; Faculty ; Female ; Humans ; Mathematics/manpower ; Physics/manpower ; Science/*manpower ; *Sexism ; United States ; Universities ; *Women
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pringle, Heather -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):364-7. doi: 10.1126/science.343.6169.364.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Commerce ; Dinosaurs ; *Fossils ; Horses ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-24
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159256/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159256/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xie, Yu -- R24 HD041028/HD/NICHD NIH HHS/ -- R24HD041028/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2014 May 23;344(6186):809-10. doi: 10.1126/science.1252743.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA. Center for Social Research, Peking University, Beijing 100871, China. yuxie@umich.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24855244" target="_blank"〉PubMed〈/a〉
    Keywords: Democracy ; Employment/*statistics & numerical data ; Internationality ; Reward ; Science/*economics/*trends ; Socioeconomic Factors ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-01-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennel, Charles -- Dressler, Alan -- New York, N.Y. -- Science. 2014 Jan 10;343(6167):140-1. doi: 10.1126/science.1244231.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24408421" target="_blank"〉PubMed〈/a〉
    Keywords: Cost-Benefit Analysis ; Planning Techniques ; Space Flight/*economics/*statistics & numerical data ; *Uncertainty ; United States ; United States National Aeronautics and Space Administration/economics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):408-9. doi: 10.1126/science.346.6208.408-b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342780" target="_blank"〉PubMed〈/a〉
    Keywords: Capital Financing/trends ; *Federal Government ; National Institutes of Health (U.S.)/*economics ; *Policy ; Science/*economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):408-9. doi: 10.1126/science.346.6208.408-a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342779" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Federal Government ; Peer Review ; *Policy ; Science/*economics ; United States ; Water Resources
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-10-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Oct 10;346(6206):152-3. doi: 10.1126/science.346.6206.152.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25301597" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Financing, Government ; *Foundations ; *Peer Review, Research ; Science/*economics ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Sep 19;345(6203):1442. doi: 10.1126/science.345.6203.1442.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25237083" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; *Federal Government ; *Policy ; Research/economics ; Science/*economics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-08-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):608. doi: 10.1126/science.345.6197.608.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104363" target="_blank"〉PubMed〈/a〉
    Keywords: *Censuses ; Costs and Cost Analysis ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 May 30;344(6187):960-1. doi: 10.1126/science.344.6187.960.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876474" target="_blank"〉PubMed〈/a〉
    Keywords: Climate Change ; Federal Government ; Foundations/*legislation & jurisprudence ; Research/economics ; Research Support as Topic/*economics ; Science/*economics ; Technology/*economics ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):718. doi: 10.1126/science.343.6172.718.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531947" target="_blank"〉PubMed〈/a〉
    Keywords: Annual Reports as Topic ; Engineering/economics/*trends ; Foundations ; Policy Making ; Science/economics/*trends ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-11-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McNutt, Marcia -- New York, N.Y. -- Science. 2014 Nov 21;346(6212):895. doi: 10.1126/science.aaa1728.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Marcia McNutt Editor-in-Chief Science Journals.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25414278" target="_blank"〉PubMed〈/a〉
    Keywords: *Data Curation ; *Schools ; Science/*education ; Students ; United States ; Volunteers
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 81
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1437-8. doi: 10.1126/science.346.6216.1437.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525219" target="_blank"〉PubMed〈/a〉
    Keywords: *Budgets ; Organizations ; Science/*economics ; United States
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  • 82
    Publication Date: 2014-01-05
    Description: In 2008, Oregon initiated a limited expansion of a Medicaid program for uninsured, low-income adults, drawing names from a waiting list by lottery. This lottery created a rare opportunity to study the effects of Medicaid coverage by using a randomized controlled design. By using the randomization provided by the lottery and emergency-department records from Portland-area hospitals, we studied the emergency department use of about 25,000 lottery participants over about 18 months after the lottery. We found that Medicaid coverage significantly increases overall emergency use by 0.41 visits per person, or 40% relative to an average of 1.02 visits per person in the control group. We found increases in emergency-department visits across a broad range of types of visits, conditions, and subgroups, including increases in visits for conditions that may be most readily treatable in primary care settings.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955206/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955206/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubman, Sarah L -- Allen, Heidi L -- Wright, Bill J -- Baicker, Katherine -- Finkelstein, Amy N -- P30 AG012810/AG/NIA NIH HHS/ -- P30AG012810/AG/NIA NIH HHS/ -- R01 AG034151/AG/NIA NIH HHS/ -- R01AG0345151/AG/NIA NIH HHS/ -- RC2 AG036631/AG/NIA NIH HHS/ -- RC2AGO36631/RC/CCR NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):263-8. doi: 10.1126/science.1246183. Epub 2014 Jan 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Bureau of Economic Research (NBER), Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24385603" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Ambulatory Care/statistics & numerical data ; Emergency Service, Hospital/*utilization ; Female ; Humans ; Inpatients/statistics & numerical data ; Insurance, Health ; Male ; Medicaid/*economics ; *Medically Uninsured ; Oregon ; Poverty ; United States
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  • 83
    Publication Date: 2014-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- Malakoff, David -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):796-7. doi: 10.1126/science.346.6211.796.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395511" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate Change ; Federal Government ; *Politics ; *Science ; United States
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  • 84
    Publication Date: 2014-08-02
    Description: Many RNA regulatory proteins controlling pre-messenger RNA splicing contain serine:arginine (SR) repeats. Here, we found that these SR domains bound hydrogel droplets composed of fibrous polymers of the low-complexity domain of heterogeneous ribonucleoprotein A2 (hnRNPA2). Hydrogel binding was reversed upon phosphorylation of the SR domain by CDC2-like kinases 1 and 2 (CLK1/2). Mutated variants of the SR domains changing serine to glycine (SR-to-GR variants) also bound to hnRNPA2 hydrogels but were not affected by CLK1/2. When expressed in mammalian cells, these variants bound nucleoli. The translation products of the sense and antisense transcripts of the expansion repeats associated with the C9orf72 gene altered in neurodegenerative disease encode GRn and PRn repeat polypeptides. Both peptides bound to hnRNPA2 hydrogels independent of CLK1/2 activity. When applied to cultured cells, both peptides entered cells, migrated to the nucleus, bound nucleoli, and poisoned RNA biogenesis, which caused cell death.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459787/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459787/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kwon, Ilmin -- Xiang, Siheng -- Kato, Masato -- Wu, Leeju -- Theodoropoulos, Pano -- Wang, Tao -- Kim, Jiwoong -- Yun, Jonghyun -- Xie, Yang -- McKnight, Steven L -- U01 GM107623/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2014 Sep 5;345(6201):1139-45. doi: 10.1126/science.1254917. Epub 2014 Jul 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA. ; Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA. ; Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA. steven.mcknight@utsouthwestern.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25081482" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Amyotrophic Lateral Sclerosis/genetics/*metabolism/pathology ; Astrocytes/*metabolism/pathology ; Cell Death ; Cell Nucleolus/*metabolism ; Cells, Cultured ; Dipeptides/genetics/*metabolism/pharmacology ; Frontotemporal Dementia/genetics/*metabolism/pathology ; Glutamate Plasma Membrane Transport Proteins/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*metabolism ; Humans ; Hydrogel ; Phosphorylation ; Protein Biosynthesis ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/metabolism ; Proteins/*genetics ; RNA, Antisense/antagonists & inhibitors/biosynthesis ; RNA, Messenger/antagonists & inhibitors/biosynthesis ; RNA, Ribosomal/antagonists & inhibitors/biosynthesis ; Repetitive Sequences, Amino Acid ; Transcription, Genetic
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  • 85
    Publication Date: 2014-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reperant, L A -- van de Burgwal, L H M -- Claassen, E -- Osterhaus, A D M E -- New York, N.Y. -- Science. 2014 Oct 24;346(6208):433-4. doi: 10.1126/science.346.6208.433-b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Department of Viroscience, Erasmus MC, 3000 CA Rotterdam, Netherlands. ; Athena Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, Netherlands. ; Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Athena Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, Netherlands. ; Artemis One Health Research Foundation, 3584 CL Utrecht, Netherlands. Department of Viroscience, Erasmus MC, 3000 CA Rotterdam, Netherlands. a.osterhaus@erasmusmc.nl.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25342793" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/therapeutic use ; Communicable Disease Control/economics/*methods ; Drug Discovery ; Ebola Vaccines/administration & dosage ; *Ebolavirus ; Hemorrhagic Fever, Ebola/drug therapy/epidemiology/*prevention & control ; Humans ; National Institute of Allergy and Infectious Diseases (U.S.) ; Private Sector/economics ; Public Sector/economics ; Public-Private Sector Partnerships/*economics ; United States ; Vaccination
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 86
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-04-20
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206184/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206184/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dominici, Francesca -- Greenstone, Michael -- Sunstein, Cass R -- R01 ES012054/ES/NIEHS NIH HHS/ -- R01 ES019560/ES/NIEHS NIH HHS/ -- R21 ES020152/ES/NIEHS NIH HHS/ -- R21 ES02147/ES/NIEHS NIH HHS/ -- R21 ES022585/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 18;344(6181):257-9. doi: 10.1126/science.1247348.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24744361" target="_blank"〉PubMed〈/a〉
    Keywords: Air Pollutants/*adverse effects ; Air Pollution/adverse effects/*legislation & jurisprudence/prevention & control ; Confounding Factors (Epidemiology) ; Government Regulation ; Humans ; Models, Statistical ; Observational Studies as Topic ; Particulate Matter/*adverse effects ; *Public Health/legislation & jurisprudence ; Public Policy ; Research Design ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 87
    Publication Date: 2014-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brandt, A R -- Heath, G A -- Kort, E A -- O'Sullivan, F -- Petron, G -- Jordaan, S M -- Tans, P -- Wilcox, J -- Gopstein, A M -- Arent, D -- Wofsy, S -- Brown, N J -- Bradley, R -- Stucky, G D -- Eardley, D -- Harriss, R -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):733-5. doi: 10.1126/science.1247045.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University, Stanford, CA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531957" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere/*chemistry ; Decision Making ; *Global Warming ; Methane/*analysis ; Natural Gas/*analysis ; *Policy Making ; United States
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-12-06
    Description: Every day, acts of violence injure more than 6000 people in the United States. Despite decades of social science arguing that joblessness among disadvantaged youth is a key cause of violent offending, programs to remedy youth unemployment do not consistently reduce delinquency. This study tests whether summer jobs, which shift focus from remediation to prevention, can reduce crime. In a randomized controlled trial among 1634 disadvantaged high school youth in Chicago, assignment to a summer jobs program decreases violence by 43% over 16 months (3.95 fewer violent-crime arrests per 100 youth). The decline occurs largely after the 8-week intervention ends. The results suggest the promise of using low-cost, well-targeted programs to generate meaningful behavioral change, even with a problem as complex as youth violence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heller, Sara B -- New York, N.Y. -- Science. 2014 Dec 5;346(6214):1219-23. doi: 10.1126/science.1257809.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Criminology, University of Pennsylvania, Philadelphia, PA, USA. University of Chicago Crime Lab, Chicago, IL, USA. hellersa@sas.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477459" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Crime Victims ; Employment/*statistics & numerical data ; Female ; Humans ; Male ; Poverty/*statistics & numerical data ; Seasons ; United States ; Violence/*prevention & control/statistics & numerical data
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tononi, Giulio -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1457. doi: 10.1126/science.1257185.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Wisconsin, 6001 Research Park Boulevard, Madison, WI 53719, USA. gtononi@wisc.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970069" target="_blank"〉PubMed〈/a〉
    Keywords: Biology/history ; Brain/physiology ; History, 20th Century ; History, 21st Century ; Neuronal Plasticity ; Neurosciences/history ; Nobel Prize ; United States
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  • 90
    Publication Date: 2014-10-18
    Description: Whether or not climate change has had an impact on the occurrence of tornadoes in the United States has become a question of high public and scientific interest, but changes in how tornadoes are reported have made it difficult to answer it convincingly. We show that, excluding the weakest tornadoes, the mean annual number of tornadoes has remained relatively constant, but their variability of occurrence has increased since the 1970s. This is due to a decrease in the number of days per year with tornadoes combined with an increase in days with many tornadoes, leading to greater variability on annual and monthly time scales and changes in the timing of the start of the tornado season.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooks, Harold E -- Carbin, Gregory W -- Marsh, Patrick T -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):349-52. doi: 10.1126/science.1257460.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Oceanic and Atmospheric Administration (NOAA)/National Severe Storms Laboratory, Norman, OK 73072, USA. harold.brooks@noaa.gov. ; NOAA/National Weather Service Storm Prediction Center, Norman, OK 73072, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324388" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate Change ; Tornadoes/*statistics & numerical data ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
    Publication Date: 2014-02-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morell, Virginia -- New York, N.Y. -- Science. 2014 Feb 14;343(6172):719. doi: 10.1126/science.343.6172.719.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24531948" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Endangered Species ; Humans ; Population Dynamics ; United States ; *Wolves
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hvistendahl, Mara -- New York, N.Y. -- Science. 2014 May 30;344(6187):953-4. doi: 10.1126/science.344.6187.953.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876469" target="_blank"〉PubMed〈/a〉
    Keywords: China ; Civil Disorders/*history ; *Democracy ; History, 20th Century ; Homicide/*history ; Humans ; Research/history/*trends ; United States
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  • 93
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fink, Gerald R -- Leshner, Alan I -- Turekian, Vaughan C -- New York, N.Y. -- Science. 2014 Jun 6;344(6188):1065. doi: 10.1126/science.1256312.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gerald R. Fink is president of AAAS and a professor at the Whitehead Institute of the Massachusetts Institute of Technology, Cambridge, MA. gfink@wi.mit.edu. ; Alan I. Leshner is chief executive officer of AAAS and executive publisher of Science. aleshner@aaas.org. ; Vaughan C. Turekian is chief international officer of AAAS and director of the AAAS Center for Science Diplomacy. vturekia@aaas.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24904126" target="_blank"〉PubMed〈/a〉
    Keywords: Cuba ; *International Cooperation ; Science/*trends ; United States
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  • 94
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-05-31
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hwang, Thomas J -- Carpenter, Daniel -- Kesselheim, Aaron S -- New York, N.Y. -- Science. 2014 May 30;344(6187):967-9. doi: 10.1126/science.1251419.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA. Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. tjhwang@post.harvard.edu akesselheim@partners.org. ; Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA. Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA 02138, USA. ; Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. tjhwang@post.harvard.edu akesselheim@partners.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24876477" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Bacterial Agents/adverse effects/supply & distribution/*therapeutic use ; Biomedical Research/economics/legislation & jurisprudence/trends ; Capital Financing ; Clinical Trials, Phase I as Topic/statistics & numerical data ; Clinical Trials, Phase II as Topic/statistics & numerical data ; Clinical Trials, Phase III as Topic/statistics & numerical data ; Communicable Diseases/*drug therapy ; Drug Approval/legislation & jurisprudence ; Drug Discovery/legislation & jurisprudence/*trends ; Drug Prescriptions/standards ; Humans ; Policy Making ; Small Business/economics/statistics & numerical data/*trends ; United States ; United States Food and Drug Administration
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-03-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hyman, Steven E -- New York, N.Y. -- Science. 2014 Mar 14;343(6176):1177. doi: 10.1126/science.1252603.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Steven E. Hyman is director of the Stanley Center for Psychiatric Research at the Broad Institute of Harvard and the Massachusetts Institute of Technology in Cambridge, MA, and a professor in the Department of Stem Cell and Regenerative Biology at Harvard University, Cambridge, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24626901" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/drug therapy ; Antipsychotic Agents/adverse effects/*therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; *Drug Discovery ; Drug Industry/trends ; Drug Prescriptions ; Humans ; International Cooperation ; Lupus Erythematosus, Systemic/drug therapy ; National Institutes of Health (U.S.) ; Schizophrenia/*drug therapy/genetics ; United States
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2014-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2014 Feb 21;343(6173):827-8. doi: 10.1126/science.343.6173.827.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24558137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Mitochondrial/*genetics ; Embryo, Mammalian ; *Fathers ; Female ; Genetic Diseases, Inborn/genetics/*prevention & control ; Genetic Therapy/*ethics ; Humans ; *Mothers ; *Oocyte Donation ; *Reproductive Techniques, Assisted ; Tissue Donors ; United States ; United States Food and Drug Administration
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  • 97
    Publication Date: 2014-05-03
    Description: A key question for climate change adaptation is whether existing cropping systems can become less sensitive to climate variations. We use a field-level data set on maize and soybean yields in the central United States for 1995 through 2012 to examine changes in drought sensitivity. Although yields have increased in absolute value under all levels of stress for both crops, the sensitivity of maize yields to drought stress associated with high vapor pressure deficits has increased. The greater sensitivity has occurred despite cultivar improvements and increased carbon dioxide and reflects the agronomic trend toward higher sowing densities. The results suggest that agronomic changes tend to translate improved drought tolerance of plants to higher average yields but not to decreasing drought sensitivity of yields at the field scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lobell, David B -- Roberts, Michael J -- Schlenker, Wolfram -- Braun, Noah -- Little, Bertis B -- Rejesus, Roderick M -- Hammer, Graeme L -- New York, N.Y. -- Science. 2014 May 2;344(6183):516-9. doi: 10.1126/science.1251423.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Environmental Earth System Science and Center on Food Security and the Environment, Stanford University, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24786079" target="_blank"〉PubMed〈/a〉
    Keywords: *Acclimatization ; *Adaptation, Physiological ; Climate Change ; Crops, Agricultural/*growth & development ; *Droughts ; Soybeans/growth & development ; *Stress, Physiological ; United States ; Zea mays/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 98
    Publication Date: 2014-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fowlie, Meredith -- Goulder, Lawrence -- Kotchen, Matthew -- Borenstein, Severin -- Bushnell, James -- Davis, Lucas -- Greenstone, Michael -- Kolstad, Charles -- Knittel, Christopher -- Stavins, Robert -- Wara, Michael -- Wolak, Frank -- Wolfram, Catherine -- New York, N.Y. -- Science. 2014 Nov 14;346(6211):815-6. doi: 10.1126/science.1261349.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California Berkeley, Berkeley, CA 94720, USA. fowlie@berkeley.edu. ; Stanford University, Palo Alto, CA 94305, USA. ; Yale University, New Haven, CT 06511, USA. ; University of California Berkeley, Berkeley, CA 94720, USA. ; University of California Davis, Davis, CA 95616, USA. ; University of Chicago, Chicago, IL 60637, USA. ; Massachusetts Institute of Technology, Cambridge, MA 02412, USA. ; Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25395524" target="_blank"〉PubMed〈/a〉
    Keywords: Carbon Dioxide/*economics ; Cost-Benefit Analysis ; *Environmental Policy ; Power Plants/*economics ; United States ; United States Environmental Protection Agency/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
    Publication Date: 2014-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorsch, Jon R -- Collins, Francis S -- Lippincott-Schwartz, Jennifer -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1452-3. doi: 10.1126/science.1259110.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Director, National Institute of General Medical Sciences, Bethesda, MD 20892, USA. jon.lorsch@nih.gov. ; Director, National Institutes of Health, Bethesda, MD 20892, USA. ; President, American Society for Cell Biology, Bethesda, MD 20814, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525228" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Specimen Banks/*standards ; Biomedical Research/*standards ; *Cell Line ; Drug Evaluation, Preclinical/*standards ; Humans ; National Institutes of Health (U.S.) ; Policy ; *Reproducibility of Results ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
    Publication Date: 2014-06-28
    Description: Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor alpha-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LAMP1. Iterative haploid screens revealed that the sialyltransferase ST3GAL4 was required for the interaction of the virus glycoprotein with LAMP1. A single glycosylated residue in LAMP1, present in susceptible species but absent in birds, was essential for interaction with the Lassa virus envelope protein and subsequent infection. The resistance of Lamp1-deficient mice to Lassa virus highlights the relevance of this receptor switch in vivo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239993/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239993/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jae, Lucas T -- Raaben, Matthijs -- Herbert, Andrew S -- Kuehne, Ana I -- Wirchnianski, Ariel S -- Soh, Timothy K -- Stubbs, Sarah H -- Janssen, Hans -- Damme, Markus -- Saftig, Paul -- Whelan, Sean P -- Dye, John M -- Brummelkamp, Thijn R -- AI081842/AI/NIAID NIH HHS/ -- AI109740/AI/NIAID NIH HHS/ -- R01 AI081842/AI/NIAID NIH HHS/ -- T32 AI007245/AI/NIAID NIH HHS/ -- U19 AI109740/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Jun 27;344(6191):1506-10. doi: 10.1126/science.1252480.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. ; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. ; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA. ; Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. ; Biochemisches Institut, Christian Albrechts-Universitat Kiel, 24118 Kiel, Germany. ; Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. t.brummelkamp@nki.nl john.m.dye1.civ@mail.mil sean_whelan@hms.harvard.edu. ; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA. t.brummelkamp@nki.nl john.m.dye1.civ@mail.mil sean_whelan@hms.harvard.edu. ; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. t.brummelkamp@nki.nl john.m.dye1.civ@mail.mil sean_whelan@hms.harvard.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24970085" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Cell Membrane/metabolism/virology ; Cells, Cultured ; Chickens ; Dystroglycans/genetics/metabolism ; Glycosylation ; Humans ; Hydrogen-Ion Concentration ; Lassa Fever/virology ; Lassa virus/*physiology ; Lysosomal-Associated Membrane Protein 1/chemistry/*metabolism ; Lysosomes/metabolism/virology ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Protein Binding ; Receptors, Virus/*metabolism ; Sialyltransferases/metabolism ; Viral Envelope Proteins/*metabolism ; *Virus Internalization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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