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  • Life Sciences (General)  (2,833)
  • Astronomy  (2,749)
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  • 1
    Publication Date: 2014-08-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennicutt, Mahlon C 2nd -- Chown, Steven L -- Cassano, John J -- Liggett, Daniela -- Massom, Rob -- Peck, Lloyd S -- Rintoul, Steve R -- Storey, John W V -- Vaughan, David G -- Wilson, Terry J -- Sutherland, William J -- England -- Nature. 2014 Aug 7;512(7512):23-5. doi: 10.1038/512023a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Texas A&M University, College Station, Texas, USA, and past-president of the Scientific Committee on Antarctic Research. ; Monash University, Victoria, Australia. ; Cooperative Institute for Research in Environmental Sciences, Department of Atmospheric and Oceanic Sciences, University of Colorado, Boulder, Colorado, USA. ; Gateway Antarctica, University of Canterbury, Christchurch, New Zealand. ; Australian Antarctic Division, and Antarctic Climate and Ecosystems Cooperative Research Centre, Hobart, Australia. ; British Antarctic Survey, Cambridge, UK. ; Antarctic Climate and Ecosystems Cooperative Research Centre, Hobart, Tasmania, Australia. ; School of Physics, University of New South Wales, Sydney, Australia. ; School of Earth Sciences, Ohio State University, Columbus, Ohio, USA. ; Conservation Science Group, Department of Zoology, University of Cambridge, Cambridge, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25100467" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Astronomy ; Atmosphere/chemistry ; Biological Evolution ; Budgets ; *Climate Change ; Conservation of Natural Resources/methods ; Ecology ; Exobiology ; Ice Cover ; International Cooperation ; Oceans and Seas ; *Policy Making ; Research/economics/*trends
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-06-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Catanzaro, Michele -- Miranda, Giuliana -- Palmer, Lisa -- Bajak, Aleszu -- England -- Nature. 2014 Jun 12;510(7504):204-6. doi: 10.1038/510204a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24919907" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Alternative Splicing ; Argentina ; Astronomy ; Brazil ; Chile ; Colombia ; Gross Domestic Product ; Research Personnel/education/standards/supply & distribution ; Science/economics/*standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2019-07-27
    Description: In May 2007, what was then the Space Life Sciences Directorate published the 2007 Space Life Sciences Strategy for Human Space Exploration, which resulted in the development and implementation of new business models and significant advances in external collaboration over the next five years. The strategy was updated on the basis of these accomplishments and reissued as the NASA Human Health and Performance Strategy in 2012, and continues to drive new approaches to innovation for the directorate. This short paper describes the open innovation successes and collaborative projects developed over this timeframe, including the efforts of the NASA Human Health and Performance Center (NHHPC), which was established to advance human health and performance innovations for spaceflight and societal benefit via collaboration in new markets.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30438
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  • 4
    Publication Date: 2019-07-27
    Description: The United Kingdom Infrared Telescope has been operating for 35 years on the summit of Mauna Kea as a premier Infrared astronomical facility. In its 35th year the telescope has been turned over to a new operating group consisting of University of Arizona, University of Hawaii and the LM Advanced Technology Center. UKIRT will continue its astronomical mission with a portion of observing time dedicated to orbital debris and Near Earth Object detection and characterization. During the past 10 years the UKIRT Wide Field CAMera (WFCAM) has been performing large area astronomical surveys in the J, H and K bands. The data for these surveys have been reduced by the Cambridge Astronomical Survey Unit in Cambridge, England and archived by the Wide Field Astronomy Unit in Edinburgh, Scotland. During January and February of 2014 the Wide Field CAMera (WFCAM) was used to scan through the geostationary satellite belt detecting operational satellites as well as nearby debris. Accurate photometric and astrometric parameters have been developed by CASU for each of the detections and all data has been archived by WFAU.
    Keywords: Astronomy
    Type: JSC-CN-31078 , AMOS Surveillance Technologies Conference 2014; 10-13 Sept. 2014; Maui, HI; United States
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  • 5
    Publication Date: 2019-08-03
    Description: The case for life on Mars grows stronger. Investigations at Gale Crater by Curiosity have revealed fine-grained sedimentary rocks inferred to represent an ancient lake environment suited to support life. In addition, Curiosity tentatively found a heterogeneous distribution of organic carbon within these sediments, consistent with the detection of native organic C in Mars meteorites. Furthermore, modern potentially habitable environments have been recognized on Mars including the N. Polar region visited by Phoenix, gully features suggesting modern water flows, and RSLs that occur seasonally suggest liquid processes. The time is ripe for missions to Mars incorporating a search for biochemical evidence of life.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN15436 , International Conference on Mars; Jul 14, 2014 - Jul 18, 2014; Pasadena, CA; United States
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  • 6
    Publication Date: 2019-07-19
    Description: We have become impatient waiting for a web page to load, but the first member of our species evolved about 150,000 years ago - a geological instant as brief and as transitory as a text message. The shortest generation time of a bacterium is a sprint at under ten minutes, whereas a 200-year old whale, turtle or tree is not unknown. Life is a phenomenon that integrates processes ranging from the near instantaneous reactions of photosynthesis to the more stately pace of evolution. Here I will elucidate these processes with radically different time scales that go to creating and maintaining the diversity of life on earth, the clocks that nature uses to time them, and how modern biology is being used to alter the natural time scales.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN11984 , Spring 2014 Biology Seminar Series; Mar 20, 2014; Williamsburg, VA; United States
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  • 7
    Publication Date: 2019-07-19
    Description: The roots of the Lunar and Planetary Laboratory (LPL) extend deep into the rich fabric of G. P. Kuiper's view of the Earth as a planet and planetary systems as expected companions to most stars, as well as the post-war emergent technology of infrared detectors suitable for astronomy. These concepts and events began with Kuiper's theoretical work at Yerkes Observatory on the origin of the Solar System, his discovery of two planetary satellites and observational work with his near-infrared spectrometer on the then-new McDonald 82-inch telescope in the mid- to late-1940s. A grant for the production of a photographic atlas of the Moon in the mid-1950s enabled him to assemble the best existing images of the Moon and acquire new photographs. This brought E. A. Whitaker and D. W. G. Arthur to Yerkes. Others who joined in the lunar work were geologist Carl S. Huzzen and grad student E. P. Moore, as well as undergrad summer students A. B. Binder and D. P. Cruikshank (both in 1958). The Atlas was published in 1959, and work began on an orthographic lunar atlas. Kuiper's view of planetary science as an interdisciplinary enterprise encompassing astronomy, geology, and atmospheric physics inspired his vision of a research institution and an academic curriculum tuned to the combination of all the scientific disciplines embraced in a comprehensive study of the planets. Arrangements were made with the University of Arizona (UA) to establish LPL in affiliation with the widely recognized Inst. of Atmospheric Physics. Kuiper moved to the UA in late 1960, taking the lunar experts, graduate student T. C. Owen (planetary atmospheres), and associate B. M. Middlehurst along. G. van Biesbroeck also joined the migration to Tucson; Binder and Cruikshank followed along as new grad students. Astronomy grad student W. K. Hartmann came into the academic program at UA and the research group at LPL in 1961. Senior faculty affiliating with LPL in the earliest years were T. Gehrels, A. B. Meinel, H. L. Johnson, and F. J. Low, each with their own grad students and associates. Work began on IR spectroscopy and a rectified lunar atlas. Kuiper and Johnson started the search for future observatory sites in N. America and Hawaii.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18014 , Annual Meeting:Division for Planetary Science; Nov 09, 2014 - Nov 14, 2014; Tucson, AZ; United States
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  • 8
    Publication Date: 2019-07-19
    Description: Starting in 2015, the NASA Bioculture System will be available to the science community to conduct cell biology and microbiology experiments on ISS. The Bioculture System carries ten environmentally independent Cassettes, which house the experiments. The closed loop fluids flow path subsystem in each Cassette provides a perfusion-based method for maintain specimen cultures in a shear-free environment by using a biochamber based on porous hollow fiber bioreactor technology. Each Cassette contains an incubator and separate insulated refrigerator compartment for storage of media, samples, nutrients and additives. The hardware is capable of fully automated or manual specimen culturing and processing, including in-flight experiment initiation, sampling and fixation, up to BSL-2 specimen culturing, and the ability to up to 10 independent cultures in parallel for statistical analysis. The incubation and culturing of specimens in the Bioculture System is a departure from standard laboratory culturing methods. Therefore, it is critical that the PI has an understanding the pre-flight test required for successfully using the Bioculture System to conduct an on-orbit experiment. Overall, the PI will conduct a series of ground tests to define flight experiment and on-orbit implementation requirements, verify biocompatibility, and determine base bioreactor conditions. The ground test processes for the utilization of the Bioculture System, from experiment selection to flight, will be reviewed. Also, pre-flight test schedules and use of COTS ground test equipment (CellMax and FiberCell systems) and the Bioculture System will be discussed.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN16080 , Annual Meeting of the American Society for Gravitational And Space Research; Oct 22, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 9
    Publication Date: 2019-07-19
    Description: The European Modular Cultivation System, EMCS, was developed by ESA for plant experiments. We performed ground testing to determine whether ARC EMCS seed cassettes could be adapted for use with tardigrades for future spaceflight experiments. Tardigrades (water bears) are small invertebrates that enter the tun state in response to desiccation or other environmental stresses. Tardigrade tuns have suspended metabolism and have been shown to be survive exposure to space vacuum, high pressure, temperature and other stresses. For spaceflight experiments using the EMCS, the organisms ideally must be able to survive desiccation and storage in the cassette at ambient temperature for several weeks prior to the initiation of the experiment by the infusion of water to the cassette during spaceflight. The ability of tardigrades to survive extremes by entering the tun state make them ideal candidates for growth experiments in the EMCS cassettes. The growth substratum in the cassettes is a gridded polyether sulfone (PES) membrane. A blotter beneath the PES membrane contains dried growth medium. The goals of our study were to (1) determine whether tardigrades survive and reproduce on PES membranes, (2) develop a consistent method for dehydration of the tardigrades with high recovery rates upon rehydration, (3) to determine an appropriate food source for the tardigrades that can also be dehydrated/rehydrated and (4) successful mock rehydration experiment in cassettes with appropriate food source. We present results that show successful multigenerational growth of tardigrades on PES membranes with a variety of wet food sources. We have successfully performed a mock rehydration with tardigrades and at least one candidate food, protonema of the moss Polytrichum, that supports multigenerational growth and whose spores germinate quickly enough to match tardigrade feeding patterns post rehydration. Our results indicate that experiments on the ISS using the tardigrade, Hypsibius dujardini and other similar species could successfully be performed in the flight verified hardware of the EMCS seed cassettes.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN16154 , Annual Meeting of the American Society for Gravitational and Space Research; Oct 23, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 10
    Publication Date: 2019-07-19
    Description: Accurate X-ray polarimetry can provide unique information on high-energy-astrophysical processes and sources. As there have been no meaningful X-ray polarization measurements of cosmic sources since our pioneering work in the 1970's, the time is ripe to explore this new parameter space in X-ray astronomy. To accomplish this requires a well-calibrated and well understood system that-particularly for an Explorer mission-has technical, cost, and schedule credibility. The system that we shall present satisfies these conditions, being based upon completely calibrated imaging- and polarization-sensitive detectors and proven X-ray-telescope technology.
    Keywords: Astronomy
    Type: M14-3644 , High Energy Astrophysics Division (HEAD) Divisional Meeting; Aug 17, 2014 - Aug 21, 2014; Chicago, IL; United States
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  • 11
    Publication Date: 2019-07-19
    Description: Since 2008 we have been monitoring accreting pulsars using the Gamma ray Burst Monitor (GBM) on Fermi. This monitoring program includes daily blind full sky searches for previously unknown or previously quiescent pulsars and source specific analysis to track the frequency evolution of all detected pulsars. To date we have detected outbursts from 23 transient accreting pulsars, including 21 confirmed or likely Be/Xray binaries. I will describe our techniques and highlight results for selected pulsars.
    Keywords: Astronomy
    Type: M14-3642 , Be X-Ray Binary Systems (BeXRB) 2014 Worksbop; Jul 07, 2014 - Jul 11, 2014; Valencia; Spain
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  • 12
    Publication Date: 2019-07-19
    Description: The parent of the Geminids, 3200 Phaethon, is a unique body in that it is classified as an asteroid, however is responsible for one of the most prolific meteor showers of the year and has shown comet-like behavior in its past (Jewitt and Li 2010). The Geminid meteor shower is also anomalous as its rates have been increasing since it was first detected. Understanding the composition and properties of meteoroids that belong to this meteor shower is an important area of study and of interest to both theoreticians and experimentalists. Using the light curve and decelerations of ten double-station Geminids as seen in the Meteoroid Environment Office's widefield meteor cameras, densities were able to be approximated using a model of meteoroid ablation by Campbell-Brown et al (2013) which employs thermal disruption to model the release of grains during ablation. Bulk densities of Geminids give unique insight into the composition of Phaethon that would only be derived by going to the asteroid itself. The bulk densities of these ten Geminids were found to be between 2.6 and 3.0 g/cm(3), supporting results from Babadzhanov (2009) and Borovicka et al (2010) which prove Phaethon has a much lower porosity than most other meteor shower parents. NASA's Meteoroid Environment Office established these two wide-field meteor cameras to observe meteors in the milligram-mass-range. Each camera consists of a 17 mm focal length Schneider lens (f/0.95) on a Watec 902U2 Ultimate CCD video camera, producing a 21.7x15.5 degree field-of-view. This configuration sees meteors down to a magnitude of +6. Data from these cameras are currently being used to calculate daily automated meteor fluxes. On the first night of operation, December 13-14, 2012, 18 double-station and 53 unique single-station Geminids were detected. The Geminid flux results from this system will be presented as well as ZHR's over the peak of the Geminids. The average flux density over the night was 0.058, 0.052, and 0.062 meteors/km(2)/hour down to a limiting magnitude of +6.5, for the double-station results and each single-station's results. This equates to ZHR's of 113, 102, and 122 respectively. Included in the flux algorithm is a process to find the collecting area per height and a method to find the limiting meteor magnitude per 10 minute time period.
    Keywords: Astronomy
    Type: M14-3403 , Asteroids Comets Meteors (ACM) 2014; Jun 30, 2014 - Jul 04, 2014; Helsinki; Finland
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  • 13
    Publication Date: 2019-07-19
    Description: The Moon's surface is covered by a layer of fine, potential reactive dust. Lunar dust contain about 12% of very fine respirable dust (less than 3 micrometers). The habitable area of any lunar landing vehicle and outpost would inevitably be contaminated with lunar dust that could pose a health risk. The purpose of the study is to evaluate the toxicity of Apollo moon dust in rodents to assess the health risk of dust exposures to humans. One of the particular interests in the study is to evaluate dustinduced changes of the expression of fibrosisrelated genes, and to identify specific signaling pathways involved in lunar dustinduced toxicity. F344 rats were exposed for 4 weeks (6h/d; 5d/wk) in noseonly inhalation chambers to concentrations of 0 (control air), 2.1, 6.8, 21, and 61 milligrams per cubic meters of lunar dust. Five rats per group were euthanized at 1 day, 1 week, 1 month, and 3 months after the last inhalation exposure. The bronchoalveolar lavage fluid (BALF) was collected by lavaging with phosphatebuffered saline (PBS). A zymosaninduced luminolbased chemiluminescence assay was used to assess the activity of BAL cells. The lavaged lung tissue was snap frozen in LN2 and total RNA was isolated using the Qigen RNeasy kit. The expression of 84 fibrosisrelated genes were analyzed using the RT2 Profiler PCR Array technique. The expression of 18 genes of interest were further measured using realtime PCR technique in all the samples. 10 out of 18 genes of interest showed persistently significant expression changes in the local lung tissue exposed to lunar dust, indicating a prolonged proinflammatory response. The expressions of several of these genes were dose and timedependent and were significantly correlated with other pathological parameters. The potential signaling pathways and upstream regulators were further analyzed using IPA pathway analysis tool based on the gene expression data. The data presented in this study, for the first time, explore the molecular mechanisms of lunar dust induced toxicity, contributing not only the risk assessment for future space exploration, but also understandings of the dustinduced toxicity in humans on earth.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30593 , COSPAR Meeting; Aug 02, 2014 - Aug 10, 2014; Moscow; Russia
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  • 14
    Publication Date: 2019-07-19
    Description: Seven x-ray mirror modules are being fabricated at the Marshall Space Flight Center (MSFC) for the Astronomical Roentgen Telescope (ART) instrument to be launched on board of the Spektrum Roentgen Gamma (SRG) Mission. As they are completed, the modules are tested and calibrated at the MSFC's 104-m Stray Flight Facility. The results of these calibration measurements and comparisons with theoretical models will be presented.
    Keywords: Astronomy
    Type: M13-3146 , SPIE Astronomical Telescopes + Instrumentation 2014; Jun 22, 2014 - Jun 27, 2014; Montreal, Quebec; Canada
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  • 15
    Publication Date: 2019-07-19
    Description: A reasonable initial condition on Earth after the Moonforming impact is that it begins as a hot global magma ocean1,2. We therefore begin our study with the mantle as a liquid ocean with a surface temperature on the order of 3000- 4000 K at a time some 100-1000 years after the impact, by which point we can hope that early transients have settled down. A 2nd initial condition is a substantial atmosphere, 100-1000 bars of H2O and CO2, supplemented by smaller amounts of CO, H2, N2, various sulfur-containing gases, and a suite of geochemical volatiles evaporated from the magma. Third, we start the Moon with its current mass at the relevant Roche limit. The 4th initial condition is the angular momentum of the Earth-Moon system. Canonical models hold this constant, whilst some recent models begin with considerably more angular momentum than is present today. Here we present a ruthlessly simplified model of Earth's cooling magmasphere based on a full-featured atmosphere and including tidal heating by the newborn Moon. Thermal blanketing by H2O-CO2 atmospheres slows cooling of a magma ocean. Geochemical volatiles - chiefly S, Na, and Cl - raise the opacity of the magma ocean's atmosphere and slow cooling still more. We assume a uniform mantle with a single internal (potential) temperature and a global viscosity. The important "freezing point" is the sharp rheological transition between a fluid carrying suspended crystals and a solid matrix through which fluids percolate. Most tidal heating takes place at this "freezing point" in a gel that is both pliable and viscous. Parameterized convection links the cooling rate to the temperature and heat generation inside the Earth. Tidal heating is a major effect. Tidal dissipation in the magma ocean is described by viscosity. The Moon is entwined with Earth by the negative feedback between thermal blanketing and tidal heating that comes from the temperature-dependent viscosity of the magma ocean. Because of this feedback, the rate that the Moon's orbit evolves is limited by the modest radiative cooling rate of Earth's atmosphere, which in effect tethers the Moon to the Earth. Consequently the Moon's orbit evolves orders of magnitude more slowly than in conventional models. Slow orbital evolution promotes capture by orbital resonances that may have been important in the Earth-Moon system
    Keywords: Astronomy
    Type: ARC-E-DAA-TN14502 , NCTS#18576-14 Goldschmidt Conference; Jun 08, 2014 - Jun 13, 2014; Sacramento, CA; United States
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  • 16
    Publication Date: 2019-07-19
    Description: Methane and ammonia both first appear at lower effective temperatures in brown dwarf atmospheres than equilibrium chemistry models would suggest. This has traditionally been understood as a consequence of vertical mixing timescales being shorter than chemical equilibration timescales in brown dwarf photospheres. Indeed the eddy diffusivity, a variable accounting for the vigor of vertical mixing, has become a standard part of the description of brown dwarf atmosphere models, along with Teff and log g. While some models have suggested that methane is less favored at lower gravity, the almost complete absence of methane in the atmospheres of directly imaged planets, such as those orbiting HR 8799, even at effective temperatures where methane is readily apparent in brown dwarf spectra, has been puzzling. To better understand the paucity of methane in low gravity atmospheres we have revisited the problem of methane chemistry and mixing. We employed a 1-D atmospheric chemistry code augmented with an updated and complete network of the chemical reactions that link CO to CH4. We find the methane abundance at altitudes at or above the effective photosphere is a strong function of surface gravity because higher g shifts the p-T structure to higher pressures (i.e., a given optical depth is proportional to p/g, a relation mitigated somewhat by pressure broadening). Thus quenching in more massive brown dwarfs occurs at a lower temperature and higher pressure, both favoring CH4. We predict that in the lowest mass young giant planets, methane will appear very late, at effective temperatures as low as 600 K rather than the 1200 K seen among field brown dwarfs. This methane deficiency has important implications for the interpretation of spectra as well as methane-based planetary companion searches, such as the NICI survey. The GPI and SPHERE surveys will test these ideas and probe atmospheric chemistry and composition in an entire new range of parameter space. A caveat is that these calculations presume that the C to O ratio is comfortably less than one; the behavior is quite different if C and O are equally abundant, and of course CH4 is always present if C exceeds O.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN13516 , Cool Stars 18; Jun 09, 2014 - Jun 13, 2014; Flagstaff, AZ; United States
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  • 17
    Publication Date: 2019-07-19
    Description: Amorphous silicates in chondritic porous interplanetary dust particles (CP-IDPs) coming from comets are dominated by glass with embedded metal and sulfides (GEMS). GEMS grains are submicron-sized rounded objects (typically 100-500) nm in diameter) with anaometer-sized (10-50 nm) Fe-Ni metal and sulfide grains embedded in an amorphous silicate matrix. Several formation processes for GEMS grains have been proposed so far, but these models are still being debated [2-5]. Bradley et al. proposed that GEMS grains are interstellar silicate dust that survived various metamorphism or alteration processes in the protoplanetary disk and that they are amorphiation products of crystalline silicates in the interstellar medium by sputter-deposition of cosmic ray irradiation, similar to space weathering [2,4]. This consideration is based on the observation of nano-sized crystals (approximately 10 nm) called relict grains in GEMS grains and their shapes are pseudomorphs to the host GEMS grains. On the other hand, Keller and Messenger proposed that most GEMS formed in the protoplanetary disk as condensates from high temperature gas [3,5]. This model is based on the fact that most GEMS grains have solar isotopic compositions and have extremely heterogeneous and non-solar elemental compositions. Keller and Messenger (2011) also reported that amorphous silicates in GEMS grains are surrounded by sulfide grains, which formed as sulfidization of metallic iron grains located on the GEMS surface. The previous studies were performed with 2D observation by using transmission electron microscopy (TEM) or scanning TEM (STEM). In order to understand the structure of GEMS grains described above more clearly, we observed 3D structure of GEMS grains by electron tomography using a TEM/STEM (JEM-2100F, JEOL) at Kyoto University. Electron tomography gives not only 3D structures but also gives higher spatial resolution (approximately a few nm) than that in conventional 2D image, which is restricted by sample thickness ) approx. or greater than 50 nm). Three cluster IDPs (L2036AA5 cluster4, L2009L8 cluster 13 and W726A2) were used for the observations. ID W726A2 was collected without silicon oil, which is ordinary used to collect IDPs, so this sample has no possibility of contaminations caused by silicon oil or solvent to rinse it [6]. The samples were embedded in epoxy risin and sliced into ultrathin sections (50-300 nm) using an ultramicotome. The sections were observed by BF-TEM and HAADF-STEM (high angle annular dark field-scanning TEM) modes. Images were obtained by rotating the sample tilt angle over a range of +/- 65 deg in 1 deg steps. The obtained images were reconstructed to slice images. Mineral phases in the slice images were estimated by comparing with a 2D elemental map obtained by an EDS (energy dispersive X-ray spectroscopy) system equipped in the TEM/STEM. Careful examination of the slice images confirmed that iron grains are embedded in the amorphous silicate matrix of the GEMS grains, but sulfide grains were mainly present on the surface of the amorphous silicate. These results are consistent with the model that GEMS grains formed as condensates [3,5], although more data are needed to conclude the origin of GEMS grains. The present study is the first successful example adapting the electron tomography to the IDPs. This type of analysis will be important for planetary material sciences in the future.
    Keywords: Astronomy
    Type: JSC-CN-30643 , Japan Geoscience Union Meeting 2014; Apr 28, 2014 - May 02, 2014; Yokohama; Japan
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  • 18
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    Publication Date: 2019-07-19
    Description: Today Mars is a cold, dry, desert planet. The atmosphere is thin and liquid water is not stable. But there is evidence that very early in its history it was warmer and wetter. Since Mariner 9 first detected fluvial features on its ancient terrains researchers have been trying to understand what climatic conditions could have permitted liquid water to flow on the surface. Though the evidence is compelling, the problem is not yet solved. The main issue is coping with the faint young sun. During the period when warmer conditions prevailed 3.5-3.8 Gy the sun's luminosity was approximately 25% less than it is today. How can we explain the presence of liquid water on the surface of Mars under such conditions? A similar problem exists for Earth, which would have frozen over under a faint sun even though the evidence suggests otherwise. Attempts to solve the "Faint Young Sun Paradox" rely on greenhouse warming from an atmosphere with a different mass and composition than we see today. This is true for both Mars and Earth. However, it is not a straightforward solution. Any greenhouse theory must (a) produce the warming and rainfall needed, (b) have a plausible source for the gases required, (c) be sustainable, and (d) explain how the atmosphere evolved to its present state. These are challenging requirements and judging from the literature they have yet to be met. In this talk I will review the large and growing body of work on the early Mars climate system. I will take a holistic approach that involves many disciplines since our goal is to present an integrated view that touches on each of the requirements listed in the preceding paragraph. I will begin with the observational evidence, which comes from the geology, mineralogy, and isotopic data. Each of the data sets presents a consistent picture of a warmer and wetter past with a thicker atmosphere. How much warmer and wetter and how much thicker is a matter of debate, but conditions then were certainly different than what they are today. I will then discuss the origin and evolution of the early atmosphere from accretion and core formation to the end of the late heavy bombardment, including estimates of the volatile inventory, outgassing history, and potential escape mechanisms. This sets the stage for a comprehensive look at the climate system of early Mars and the attempts to solve the faint young sun problem. I will review the basic physics involved and then step through the different ideas highlighting their strengths and weaknesses. I will then conclude with a summary and a discussion of potentially promising avenues of future research
    Keywords: Astronomy
    Type: ARC-E-DAA-TN13292 , Colloquium at York University, Dept. of Earth and Space Science and Engineering; May 14, 2014; Toronto; Canada
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  • 19
    Publication Date: 2019-07-20
    Description: Rodent research in space is needed to advance our understanding of the health risks,consequences and possible countermeasures to protect crew during future, long duration missions. TheAnimal Enclosure Module (AEM) was designed originally to support habitation of rats and mice onrelatively short duration, Shuttle missions (〈19 days). The AEM was flown previously on 27 SpaceShuttle missions, and recently was modified extensively to support future long duration space biology andbiomedical research on the International Space Station (ISS). In consultation with a Science WorkingGroup comprised of veterinarians and investigators experienced in rodent spaceflight experimentation inspace, the Rodent Habitat project team at Ames Research Center modified existing hardware, developednew hardware, operations, and science activities, and performed a series of ground-based operational andscience habitat verification tests in preparation for the first validation flight.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN12037 , NASA Human Research Program Investigatorsý Workshop (HRP 2014); Feb 12, 2014 - Feb 13, 2014; Galveston, TX; United States
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  • 20
    Publication Date: 2019-07-13
    Description: The far-infrared and submillimeter portions of the electromagnetic spectrum provide a unique view of the astrophysical processes present in the early universe. Our ability to fully explore this rich spectral region has been limited, however, by the size and cost of the cryogenic spectrometers required to carry out such measurements. Micro-Spec (u-Spec) is a high-sensitivity, direct-detection spectrometer concept working in the 450-1000 micromillimeter wavelength range which will enable a wide range of flight missions that would otherwise be challenging due to the large size of current instruments with the required spectral resolution and sensitivity. The spectrometer design utilizes two internal antenna arrays, one for transmitting and one for receiving, superconducting microstrip transmission lines for power division and phase delay, and an array of microwave kinetic inductance detectors (MKIDs) to achieve these goals. The instrument will be integrated on a approximately 10 square cm silicon chip and can therefore become an important capability under the low background conditions accessible via space and high-altitude borne platforms. In this paper, an optical design methodology for Micro-Spec is presented, with particular attention given to its twodimensional diffractive region, where the light of different wavelengths is focused on the different detectors. The method is based on the maximization of the instrument resolving power and minimization of the RMS phase error on the instrument focal plane. This two-step optimization can generate geometrical configurations given specific requirements on spectrometer size, operating spectral range and performance. A point design with resolving power of 257, an RMS phase error less than 0.1 radians and four stigmatic points was developed for initial demonstration and will be the basis of future instruments with resolving power up to about 1200.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN18906 , International Astronautical Congress; Sep 29, 2014 - Oct 03, 2014; Toronto; Canada
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  • 21
    Publication Date: 2019-07-13
    Description: NGC6872, hereafter the Condor, is a large spiral galaxy that is interacting with its closest companion, the S0 galaxy IC 4970. The extent of the Condor provides an opportunity for detailed investigation of the impact of the interaction on the current star formation rate and its history across the galaxy, on the age and spatial distribution of its stellar population, and on the mechanism that drives the star formation activity. To address these issues we analyzed the far-ultraviolet (FUV) to near-infrared (near-IR) spectral energy distribution of seventeen 10 kpc diameter regions across the galaxy, and derived their star formation history, current star formation rate, and stellar population and mass. We find that most of the star formation takes place in the extended arms, with very little star formation in the central 5 kpc of the galaxy, in contrast to what was predicted from previous numerical simulations. There is a trend of increasing star formation activity with distance from the nucleus of the galaxy, and no evidence for a recent increase in the current star formation rate due to the interaction. The nucleus itself shows no significant current star formation activity. The extent of the Condor also provides an opportunity to test the applicability of a single standard prescription for conversion of the FUV + IR (22 micrometer) intensities to a star formation rate for all regions. We find that the conversion factor differs from region to region, arising from regional differences in the stellar populations.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN17892 , The Astrophysical Journal; 795; 1; 89
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  • 22
    Publication Date: 2019-07-13
    Description: We describe the science motivation and development of a pair production telescope for medium-energy (approximately 5-200 Mega electron Volts) gamma-ray polarimetry. Our instrument concept, the Advanced Energetic Pair Telescope (AdEPT), takes advantage of the Three-Dimensional Track Imager, a low-density gaseous time projection chamber, to achieve angular resolution within a factor of two of the pair production kinematics limit (approximately 0.6 deg at 70 Mega electron Volts), continuum sensitivity comparable with the Fermi-LAT front detector (is less than 3 x 10(exp -6) Mega electron Volts per square centimeter per second at 70 Mega electron Volts), and minimum detectable polarization less than 10% for a 10 milliCrab source in 10(exp 6) s.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN17829 , Astroparticle Physics; 59; 18-28
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  • 23
    Publication Date: 2019-07-13
    Description: The recurrent nova T Pyx underwent its sixth historical outburst in 2011, and became the subject of an intensive multi-wavelength observational campaign.We analyze data from the Swift and Suzaku satellites to produce a detailed X-ray light curve augmented by epochs of spectral information. X-ray observations yield mostly non-detections in the first four months of outburst, but both a super-soft and hard X-ray component rise rapidly after Day 115. The super-soft X-ray component, attributable to the photosphere of the nuclear-burning white dwarf, is relatively cool (approximately 45 electron volts) and implies that the white dwarf in T Pyx is significantly below the Chandrasekhar mass (approximately 1 M). The late turn-on time of the super-soft component yields a large nova ejecta mass (approximately greater than 10(exp 5) solar mass), consistent with estimates at other wavelengths. The hard X-ray component is well fit by a approximately 1 kiloelectron volt thermal plasma, and is attributed to shocks internal to the 2011 nova ejecta. The presence of a strong oxygen line in this thermal plasma on Day 194 requires a significantly super-solar abundance of oxygen and implies that the ejecta are polluted by white dwarf material. The X-ray light curve can be explained by a dual-phase ejection, with a significant delay between the first and second ejection phases, and the second ejection finally released two months after outburst. A delayed ejection is consistent with optical and radio observations of T Pyx, but the physical mechanism producing such a delay remains a mystery.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN16953 , The Astrophysical Journal; 788; 2; 130
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  • 24
    Publication Date: 2019-07-13
    Description: The future of x-ray astronomy depends upon development of x-ray telescopes with larger aperture areas (approx. = 3 square meters) and fine angular resolution (approx. = 1 inch). Combined with the special requirements of nested grazing-incidence optics, the mass and envelope constraints of space-borne telescopes render such advances technologically and programmatically challenging. Achieving this goal will require precision fabrication, alignment, mounting, and assembly of large areas (approx. = 600 square meters) of lightweight (approx. = 1 kilogram/square meter areal density) high-quality mirrors at an acceptable cost (approx. = 1 million dollars/square meter of mirror surface area). This paper reviews relevant technological and programmatic issues, as well as possible approaches for addressing these issues-including active (in-space adjustable) alignment and figure correction.
    Keywords: Astronomy
    Type: M14-4110 , SPIE Optics + Photonics; Aug 17, 2014 - Aug 21, 2014; San Diego, CA; United States
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  • 25
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    In:  CASI
    Publication Date: 2019-07-13
    Description: Presentation to POIWG meeting at MSFC to discuss planned operations for upcoming FFL-01 mission on SpaceX-5. Will show hardware suite used, on-orbit operations, training strategy, and data handling architecture.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13057 , Payload Operations and Integration Working Group (POIWG); Jan 28, 2014; Huntsville, AL; United States
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  • 26
    Publication Date: 2019-07-13
    Description: Surveys above 10 keV represent one of the best resources to provide an unbiased census of the population of active galactic nuclei (AGNs). We present the results of 60 months of observation of the hard X-ray sky with Swift/Burst Alert Telescope (BAT). In this time frame, BAT-detected (in the 15-55 keV band) 720 sources in an all-sky survey of which 428 are associated with AGNs, most of which are nearby. Our sample has negligible incompleteness and statistics a factor of approx. 2 larger over similarly complete sets of AGNs. Our sample contains (at least) 15 bona fide Compton-thick AGNs and 3 likely candidates. Compton-thick AGNs represent approx. 5% of AGN samples detected above 15 keV. We use the BAT data set to refine the determination of the log N-log S of AGNs which is extremely important, now that NuSTAR prepares for launch, toward assessing the AGN contribution to the cosmic X-ray background. We show that the log N-log S of AGNs selected above 10 keV is now established to approx. 10% precision. We derive the luminosity function of Compton-thick AGNs and measure a space density of 7.9(+4.1/2.9) 10(exp 5)/cubic Mpc for objects with a de-absorbed luminosity larger than 2 10(exp 42) erg / s. As the BAT AGNs are all mostly local, they allow us to investigate the spatial distribution of AGNs in the nearby universe regardless of absorption. We find concentrations of AGNs that coincide spatially with the largest congregations of matter in the local (much 〈 85 Mpc) universe. There is some evidence that the fraction of Seyfert 2 objects is larger than average in the direction of these dense regions..
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN9517 , The Astrophysical Journal; 749; 1; 21
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  • 27
    Publication Date: 2019-07-13
    Description: Our understanding of the dynamical process in the space environment has increased dramatically. A relatively new field of study called "Space Weather" has emerged in the last few decades. Fundamental to the study of space weather is an understanding of how space weather events such as solar flares and coronal mass ejections impact spacecraft in varying orbits and distances around the Sun. Specialized space weather satellite monitoring systems operated by the National Aeronautics and Space Administration (NASA) and the National Oceanic and Atmospheric Administration (NOAA) allow scientists to predict space weather events affecting critical systems on and orbiting the Earth. However, the Spitzer Space Telescope is in an orbit far outside the areas covered by those space weather monitoring systems. This poses a challenge for the Spitzer's Mission Operations Team in determining whether space weather events affect Spitzer.
    Keywords: Astronomy
    Type: International Conference on Space Operations (SpaceOps 2014); May 05, 2014 - May 09, 2014; Pasadena, CA; United States
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  • 28
    Publication Date: 2019-07-13
    Description: A Starshade is a sunflower-shaped satellite with a large inner disk structure surrounded by petals that flies in formation with a space-borne telescope, creating a deep shadow around the telescope over a broad spectral band to permit nearby exoplanets to be viewed. Removing extraneous starlight before it enters the observatory optics greatly loosens the tolerances on the telescope and instrument that comprise the optical system, but the nature of the Starshade dictates a large deployable structure capable of deploying to a very precise shape. These shape requirements break down into key mechanical requirements, which include the rigid-body position and orientation of each of the petals that ring the periphery of the Starshade. To verify our capability to meet these requirements, we modified an existing flight-like Astromesh reflector, provided by Northrup Grumman, as the base ring to which the petals attach. The integrated system, including 4 of the 30 flight-like subscale petals, truss, connecting spokes and central hub, was deployed tens of times in a flight-like manner using a gravity compensation system. After each deployment, discrete points in prescribed locations covering the petals and truss were measured using a highly-accurate laser tracker system. These measurements were then compared against the mechanical requirements, and the as-measured data shows deployment accuracy well within our milestone requirements and resulting in a contrast ratio consistent with exoplanet detection and characterization.
    Keywords: Astronomy
    Type: SPIE Astronomical Telescopes + Instrumentation 2014 Symposium; Jun 22, 2014 - Jun 27, 2014; Montreal, QC; Canada
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  • 29
    Publication Date: 2019-07-13
    Description: Understanding the genetic, physiological, and behavioral effects of spaceflight on living organisms and elucidating the molecular mechanisms that underlie these effects are high priorities for NASA. Certain organisms, known as model organisms, are widely studied to help researchers better understand how all biological systems function. Small model organisms such as nem-atodes, slime mold, bacteria, green algae, yeast, and moss can be used to study the effects of micro- and reduced gravity at both the cellular and systems level over multiple generations. Many model organisms have sequenced genomes and published data sets on their transcriptomes and proteomes that enable scientific investigations of the molecular mechanisms underlying the adaptations of these organisms to space flight.
    Keywords: Life Sciences (General)
    Type: NASA-FS-2014-10-01-ARC , ARC-E-DAA-TN18374 , American Society for Gravitational and Space Research (ASGSR 2014) Meeting; Oct 22, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 30
    Publication Date: 2019-07-13
    Description: Rodent Research on the International Space Station (ISS) is one of the highest priority science activities being supported by NASA and is planned for up to two flights per year. The first Rodent Research flight, Rodent Research-1 (RR-1) validates the hardware and basic science operations (dissections and tissue preservation). Subsequent flights will add new capabilities to support rodent research on the ISS. RR-1 will validate the following capabilities: animal husbandry for up to 30 days, video downlink to support animal health checks and scientific analysis, on-orbit dissections, sample preservation in RNA. Later and formalin, sample transfer from formalin to ethanol (hindlimbs), rapid cool-down and subsequent freezing at -80 of tissues and carcasses, sample return and recovery. RR-2, scheduled for SpX-6 (Winter 20142015) will add the following capabilities: animal husbandry for up to 60 days, RFID chip reader for individual animal identification, water refill and food replenishment, anesthesia and recovery, bone densitometry, blood collection (via cardiac puncture), blood separation via centrifugation, soft tissue fixation in formalin with transfer to ethanol, and delivery of injectable drugs that require frozen storage prior to use. Additional capabilities are also planned for future flights and these include but are not limited to male mice, live animal return, and the development of experiment unique equipment to support science requirements for principal investigators that are selected for flight. In addition to the hardware capabilities to support rodent research the Crew Office has implemented a training program in generic rodent skills for all USOS crew members during their pre-assignment training rotation. This class includes training in general animal handling, euthanasia, injections, and dissections. The dissection portion of this training focuses on the dissection of the spleen, liver, kidney with adrenals, brain, eyes, and hindlimbs. By achieving and maintaining proficiency in these basic skills as part of the nominal astronaut training curriculum this allows the rodent research program to focus the mission specific crew training on scientific requirements of research and operations flow.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN18472 , Annual American Society for Gravitational and Space Research; Oct 23, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 31
    Publication Date: 2019-07-13
    Description: We have shown using ESA's Biopan facility flown in Earth orbit that when exposed to the space environment for 2 weeks the survival rate of Synechococcus (Nageli), a halophilic cyanobacterium isolated from the evaporitic gypsum-halite crusts that form along the marine intertidal, and Halorubrum chaoviator a member of the Halobacteriaceae isolated from an evaporitic NaCl crystal obtained from a salt evaporation pond, were higher than all other test organisms except Bacillus spores. These results led to the EXPOSE-R mission to extend and refine these experiments as part of the experimental package for the external platform space exposure facility on the ISS. The experiment was flown in February 2009 and the organisms were exposed to low-Earth orbit for nearly 2 years. Samples were either exposed to solar ultraviolet (UV)-radiation (lambda is greater than 110 nm or lambda is greater than 200 nm, cosmic radiation (dosage range 225-320 mGy), or kept in darkness shielded from solar UV-radiation. Half of each of the UV-radiation exposed samples and dark samples were exposed to space vacuum and half kept at 105 pascals in argon. Duplicate samples were kept in the laboratory to serve as unexposed controls. Ground simulation control experiments were also performed. After retrieval, organism viability was tested using Molecular Probes Live-Dead Bac-Lite stain and by their reproduction capability. Samples kept in the dark, but exposed to space vacuum had a 90 +/- 5% survival rate compared to the ground controls. Samples exposed to full UV-radiation for over a year were bleached and although results from Molecular Probes Live-Dead stain suggested approximately 10% survival, the data indicate that no survival was detected using cell growth and division using the most probable number method. Those samples exposed to attenuated UV-radiation exhibited limited survival. Results from of this study are relevant to understanding adaptation and evolution of life, the future of life beyond earth, the potential for interplanetary transfer of viable microbes via meteorites and dust particles as well as spacecraft, and the physiology of halophiles.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN23546 , International Journal of Astrobiology; 14; 1; 123-128
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  • 32
    Publication Date: 2019-07-12
    Description: The goal of this project is to select and advance methods to enable real-time sampling, microbiological analysis, and sanitation of crops grown on the International Space Station (ISS). These methods would validate the microbiological quality of crops grown for consumption to ensure safe and palatable fresh foods. This would be achieved through the development / advancement of microbiological sample collection, rapid pathogen detection and effective sanitation methods that are compatible with a microgravity environment.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN14972
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  • 33
    Publication Date: 2019-07-12
    Description: To demonstrate and model a long range-co-operative attractive force between a pair of satellites in order to fly satellite formations for future interferometer and telescope applications
    Keywords: Astronomy
    Type: KSC-E-DAA-TN14644
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  • 34
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN13837
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  • 35
    Publication Date: 2019-07-12
    Description: During hindlimb unloading (HU) dramatic fluid shifts occur within minutes of the suspension, leading to a less precise matching of blood flow to O2 demands of skeletal muscle. Vascular resistance directs blood away from certain muscles, such as the soleus (SOL). The muscle volume gradually reduces in these muscles so that eventually the relative blood flow returns to normal. It is generally believed that muscle volume change is not due to O2 depletion, but a consequence of disuse. However, the volume of the unloaded rat muscle declines over the course of weeks, whereas the redistribution of blood flow occurs immediately. Using a Krogh Cylinder Model, the distribution of O2 was predicted in two skeletal muscles: SOL and gastrocnemius (GAS). Effects of the muscle blood flow, volume, capillary density, and O2 uptake, are included to calculate the pO2 at rest and after 10 min and 15 days of unloading. The model predicts that 32 percent of the SOL muscle tissue has a pO2 1.25 mm Hg within 10 min, whereas the GAS maintains normal O2 levels, and that equilibrium is reached only as the SOL muscle cells degenerate. The results provide evidence that there is an inadequate O2 supply to the mitochondria in the SOL muscle after 10 min HU.
    Keywords: Life Sciences (General)
    Type: NASA/TM-2014-216631 , E-18834 , GRC-E-DAA-TN12351
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  • 36
    Publication Date: 2019-07-19
    Description: Life has had a profound impact on the geological history of our planet, which in turn has had a profound impact back on the evolution of life. Life has been able to adapt and spread into every planetary nook and cranny. At this point in history, life is becoming able to engineer itself, with extreme consequences we are only dimly able to foresee. One probable outcome will be the facilitation of the expansion of the range of life to beyond our planetary cradle, an evolutionary step as profound as the ancient transition from sea to land. Current efforts at NASA and aboard the International Space Station will be discussed in this context.
    Keywords: Life Sciences (General)
    Type: JSC-CN-32196
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  • 37
    Publication Date: 2019-07-19
    Description: Pollen from members of the Cupressaceae are major aeroallergens in many parts of the world. In the south central and southwest United States, Juniperus pollen is the most important member of this family with J. ashei (JA) responsible for severe winter allergy symptoms in Texas and Oklahoma. In New Mexico, pollen from J. monosperma (JM) and other Juniperus species are important contributors to spring allergies, while J. pinchotii (JP) pollinates in the fall affecting sensitive individuals in west Texas, southwest Oklahoma and eastern New Mexico. Throughout this region, JA, JM, and JP occur in dense woodland populations. Generally monitoring for airborne allergens is conducted in urban areas, although the source for tree pollen may be forested areas distant from the sampling sites. Improved pollen forecasts require a better understanding of pollen production at the source. The current study was undertaken to examine the aerobiology of several Juniperus species at their source areas for the development of new pollen forecasting initiatives.
    Keywords: Life Sciences (General)
    Type: M14-3771 , International Congress of Biometeorology; Sep 28, 2014 - Oct 02, 2014; Cleveland, OH; United States
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  • 38
    Publication Date: 2019-07-19
    Description: Using the Gamma Ray Burst Monitor (GBM) on-board Fermi, we are monitoring the hard X-ray/soft gamma ray sky using the Earth occultation technique (EOT). Each time a source in our catalog is occulted by (or exits occultation by) the Earth, we measure its flux using the change in count rates due to the occultation. Currently we are using CTIME data with 8 energy channels spanning 8 keV to 1 MeV for the GBM NaI detectors for daily monitoring. Light curves, updated daily, are available on our website http://heastro.phys.lsu.edu/gbm. Our software is also capable of performing the Earth occultation monitoring using up to 128 energy bands, or any combination of those bands, using our 128-channel, 4-s CSPEC data. The GBM BGO detectors, sensitive from about 200 keV to 40 keV, can also be used with this technique. In our standard application of the EOT, we use a catalog of sources to drive the measurements. To ensure that our catalog is complete, our team has developed an Earth occultation imaging method. In this talk, I will describe both techniques and the current data products available. I will highlight recent and important results from the GBM EOT, including the current status of our observations of hard X-ray variations in the Crab Nebula.
    Keywords: Astronomy
    Type: M14-3744 , Fermi Asian Network Workshop; Jul 28, 2014 - Aug 01, 2014; Yilan; Taiwan, Province of China
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  • 39
    Publication Date: 2019-07-19
    Description: In the summer of 2012, the High-resolution Coronal Imager (Hi-C) flew aboard a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore calculate how the intensity scales from a low-resolution (AIA) pixels to high-resolution (Hi-C) pixels for both the dynamic events and "background" emission (meaning, the steady emission over the 5 minutes of data acquisition time). We find there is no evidence of substructure in the background corona; the intensity scales smoothly from low-resolution to high-resolution Hi-C pixels. In transient events, however, the intensity observed with Hi-C is, on average, 2.6 times larger than observed with AIA. This increase in intensity suggests that AIA is not resolving these events. This result suggests a finely structured dynamic corona embedded in a smoothly varying background.
    Keywords: Astronomy
    Type: M14-3436 , American Astronomical Society (AAS) Meeting; Jun 01, 2014 - Jun 05, 2014; Boston, MA; United States
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  • 40
    Publication Date: 2019-07-19
    Description: Fischer-Tropsch Type (FTT) synthesis of organic compounds has been hypothesized to occur in the early solar nebula that formed our Solar System. FTT is a collection of abiotic chemical reactions that convert a mixture of carbon monoxide and hydrogen over nano-catalysts into hydrocarbons and other more complex aromatic compounds. We hypothesized that FTT can generate similar organic compounds as those seen in chondritic meteorites; fragments of asteroids that are characteristic of the early solar system. Specific goals for this project included: 1) determining the effects of different FTT catalyst, reaction temperature, and cycles on organic compounds produced, 2) imaging of organic coatings found on the catalyst, and 3) comparison of organic compounds produced experimentally by FTT synthesis and those found in the ordinary chondrite LL5 Chelyabinsk meteorite. We used Pyrolysis Gas Chromatography Mass Spectrometry (PY-GCMS) to release organic compounds present in experimental FTT and meteorite samples, and Scanning Electron Microscopy (SEM) to take images of organic films on catalyst grains.
    Keywords: Astronomy
    Type: JSC-CN-31649
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  • 41
    Publication Date: 2019-07-19
    Description: Subsequent to the detections AGILE and Fermi/LAT of the gammaray flares from the Crab Nebula in the fall of 2010, this team has been monitoring the XRay emission from the Crab on a regular basis. XRay observations have taken place typically once per month when viewing constraints allow and more recently four times per year. There have been notable exceptions, e.g. in April of 2011 and March 2013 when we initiated a set of Chandra Target of opportunity observations in conjunction with bright gammaray flares. For much of the time regular HST observations were made in conjunction with the Chandra observations. The aim of this program to further characterize, in depth, the XRay and optical variations that take place in the nebula, and by so doing determine the regions which contribute to the harder Xray variations and, if possible, determine the precise location within the Nebula of the origin of the gammaray flares. As part of this project members of the team have developed Singular Value Decomposition techniques to sequences of images in order to more accurately characterize features. The current status of the project will be presented highlighting studies of the inner knot and possible correlations with the flares.
    Keywords: Astronomy
    Type: M15-4153 , 15 Years of Science with Chandra Symposium; Nov 18, 2014 - Nov 21, 2014; Boston, MA; United States
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  • 42
    Publication Date: 2019-07-19
    Description: The aim of our ground testing was to demonstrate the capability of safely putting specific model organisms into dehydrated stasis, and to later rehydrate and successfully grow them inside flight proven ARC EMCS seedling cassettes. The ARC EMCS seedling cassettes were originally developed to support seedling growth during space flight. The seeds are attached to a solid substrate, launched dry, and then rehydrated in a small volume of media on orbit to initiate the experiment. We hypothesized that the same seedling cassettes should be capable of acting as culture chambers for a wide range of organisms with minimal or no modification. The ability to safely preserve live organisms in a dehydrated state allows for on orbit experiments to be conducted at the best time for crew operations and more importantly provides a tightly controlled physiologically relevant growth experiment with specific environmental parameters. Thus, we performed a series of ground tests that involved growing the organisms, preparing them for dehydration on gridded Polyether Sulfone (PES) membranes, dry storage at ambient temperatures for varying periods of time, followed by rehydration. Inside the culture cassettes, the PES membranes were mounted above blotters containing dehydrated growth media. These were mounted on stainless steel bases and sealed with plastic covers that have permeable membrane covered ports for gas exchange. The results showed we were able to demonstrate acceptable normal growth of C.elegans (nematodes), E.coli (bacteria), S.cerevisiae (yeast), Polytrichum (moss) spores and protonemata, C.thalictroides (fern), D.discoideum (amoeba), and H.dujardini (tardigrades). All organisms showed acceptable growth and rehydration in both petri dishes and culture cassettes initially, and after various time lengths of dehydration. At the end of on orbit ISS European Modular Cultivation System experiments the cassettes could be frozen at ultra-low temperatures, refrigerated, or chemically preserved before being returned to Earth for analyses. Our results suggest that with protocol modifications and future verification testing we can utilize the versatile EMCS to conduct tightly controlled experiments inside our culture cassettes for a wide variety of organisms. These physiological experiments would be designed to answer questions at the molecular level about the specific stress responses of space flight.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN15861 , Annual American Society for Gravitational and Space Research; Oct 23, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 43
    Publication Date: 2019-07-19
    Description: The Veggie hardware validation test, VEG-01, was conducted on the International Space Station during Expeditions 39 and 40 from May through June of 2014. The Veggie hardware and the VEG-01 experiment payload were launched to station aboard the SpaceX-3 resupply mission in April, 2014. Veggie was installed in an Expedite-the-Processing-of-Experiments-to-Space-Station (ExPRESS) rack in the Columbus module, and the VEG-01 validation test was initiated. Veggie installation was successful, and power was supplied to the unit. The hardware was programmed and the root mat reservoir and plant pillows were installed without issue. As expected, a small amount of growth media was observed in the sealed bags which enclosed the plant pillows when they were destowed. Astronaut Steve Swanson used the wet/dry vacuum to clean up the escaped particles. Water insertion or priming the first plant pillow was unsuccessful as an issue prevented water movement through the quick disconnect. All subsequent pillows were successfully primed, and the initial pillow was replaced with a backup pillow and successfully primed. Six pillows were primed, but only five pillows had plants which germinated. After about a week and a half it was observed that plants were not growing well and that pillow wicks were dry. This indicated that the reservoir was not supplying sufficient water to the pillows via wicking, and so the team reverted to an operational fix which added water directly to the plant pillows. Direct watering of the pillows led to a recovery in several of the stressed plants; a couple of which did not recover. An important lesson learned involved Veggie's bellows. The bellows tended to float and interfere with operations when opened, so Steve secured them to the baseplate during plant tending operations. Due to the perceived intensity of the LED lights, the crew found it challenging to both work under the lights and read crew procedures on their computer. Although the lights are not a safety hazard, for visual comfort crewmembers were advised to wear sunglasses when working with the plants and then they can lift glasses to read procedures. Steve Swanson had already trail-blazed this procedure when he initiated VEG-01. The temperature and humidity data logger was relocated mid-experiment to provide measurements on both sides of the unit. Images of the plants were downlinked weekly, and videos of installation and harvest were recorded. This imaging frequency was not sufficient to monitor and respond to changes in plant growth. Plants, samples, and data loggers will be returned on SpaceX-4, scheduled to return the fall of 2014. Lessons learned will be translated into hardware and operational modifications for future Veggie payloads.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN15514 , American Society for Gravitational and Space Research 2014; Oct 22, 2014 - Oct 26, 2014; Pasadena, CA; United States
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  • 44
    Publication Date: 2019-07-19
    Description: From its inception in 2000, one of the primary tasks of the Biomedical Data Reduction Analysis (BDRA) group has been translation of large amounts of data into information that is relevant to the audience receiving it. BDRA helps translate data into an integrated model that supports both operational and research activities. This data integrated model and subsequent visual data presentations have contributed to BDRA's success in delivering the message (i.e., the story) that its customers have needed to communicate. This success has led to additional collaborations among groups that had previously not felt they had much in common until they worked together to develop solutions in an integrated fashion. As more emphasis is placed on working with "big data" and on showing how NASA's efforts contribute to the greater good of the American people and of the world, it becomes imperative to visualize the story of our data to communicate the greater message we need to share. METHODS To create and expand its data integrated model, BDRA has incorporated data from many different collaborating partner labs and other sources. Data are compiled from the repositories of the Lifetime Surveillance of Astronaut Health and the Life Sciences Data Archive, and from the individual laboratories at Johnson Space Center that support collection of data from medical testing, environmental monitoring, and countermeasures, as designated in the Medical Requirements Integration Documents. Ongoing communication with the participating collaborators is maintained to ensure that the message and story of the data are retained as data are translated into information and visual data presentations are delivered in different venues and to different audiences. RESULTS We will describe the importance of storytelling through an integrated model and of subsequent data visualizations in today's scientific presentations and discuss the collaborative methods used. We will illustrate the discussion with examples of graphs from BDRA's past work supporting operations and/or research efforts.
    Keywords: Life Sciences (General)
    Type: JSC-CN-32245 , 2015 NASA Human Research Program Investigators'' Workshop (HRP IWS 2015); Jan 13, 2015 - Jan 15, 2015; Galveston, TX; United States
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  • 45
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-19
    Description: The Nuclear Spectroscopic Telescope Array (NuSTAR) mission was launched June 13, 2012. During the next two pears NuSTAR observed two Gamma Ray Bursts, GRBs 130427A and 130925A. I will describe here the NuSTAR GRB results and discuss their implications on the GRB field.
    Keywords: Astronomy
    Type: M14-3887 , COSPAR Scientific Assembly; Aug 04, 2014 - Aug 10, 2014; Moscow; Russia
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  • 46
    Publication Date: 2019-07-19
    Description: We present a historical (and personal) overview beginning with the pioneering contributions of Professor R. Novick and the team at the Columbia Astrophysics Laboratory. We will end with our (biased) outlook for the future.
    Keywords: Astronomy
    Type: M14-3607 , X-ray Polarisation in Astrophysics - A Window about to Open?; Aug 25, 2014 - Aug 28, 2014; Stockholm; Sweden
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  • 47
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-19
    Description: The launch of the Fermi mission has enabled critical improvements in the field of magnetars, in particular with the Gamma-ray Burst Monitor, which is a all sky high-energy transient detector (8 keV - 40 MeV). In the last six years, the instrument has detected emission from 8 sources, and co-discovered two in synergy with the Swift mission. I will present the 5-year GBM magnetar results, focusing on the burst emission properties (spectral and temporal) per source as well as comparisons across sources.
    Keywords: Astronomy
    Type: M14-3401 , Committee on Space Research (COSPAR) Scientific Assembly; Aug 02, 2014 - Aug 10, 2014; Moscow; Russia
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  • 48
    Publication Date: 2019-07-19
    Description: The Moon's surface is covered by a layer of fine, potential reactive dust. Lunar dust contain about 12% respirable very fine dust (less than 3 micrometers). The habitable area of any lunar landing vehicle and outpost would inevitably be contaminated with lunar dust that could pose a health risk. The purpose of the study is to analyze the dynamics of global gene expression changes in lung tissues of rats exposed to lunar dust particles. F344 rats were exposed for 4 weeks (6h/d; 5d/wk) in noseonly inhalation chambers to concentrations of 0 (control air), 2.1, 6.8, 21, and 61 mg/m3 of lunar dust. Animals were euthanized at 1 day and 13 weeks after the last inhalation exposure. After being lavaged, lung tissue from each animal was collected and total RNA was isolated. Four samples of each dose group were analyzed using Agilent Rat GE v3 microarray to profile global gene expression of 44K transcripts. After background subtraction, normalization, and log transformation, t tests were used to compare the mean expression levels of each exposed group to the control group. Correction for multiple testing was made using the method of Benjamini, Krieger, and Yekuteli (1) to control the false discovery rate. Genes with significant changes of at least 1.75 fold were identified as genes of interest. Both low and high doses of lunar dust caused dramatic, dosedependent global gene expression changes in the lung tissues. However, the responses of lung tissue to low dose lunar dust are distinguished from those of high doses, especially those associated with 61mg/m3 dust exposure. The data were further integrated into the Ingenuity system to analyze the gene ontology (GO), pathway distribution and putative upstream regulators and gene targets. Multiple pathways, functions, and upstream regulators have been identified in response to lunar dust induced damage in the lung tissue.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30592 , COSPAR Meeting; Aug 02, 2014 - Aug 10, 2014; Moscow; Russia
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  • 49
    Publication Date: 2019-07-19
    Description: Supra-arcade downflows (SADs) observed above flaring active regions during long-duration events are theorized to be signatures of magnetic reconnection. Observations of SADs strongly indicate an association with shrinking reconnected flux tubes characterized by a specific magnetic topology. Plasmoids comprise another proposed group of observational reconnection signatures. While some plasmoids occur under nearly the same conditions as SADs, the magnetic configuration of the two phenomena are quite incongruous, yet they are often categorized together. We present distinguishing characteristics between SADs and plasmoids and indicate how their respective observations may yield insight into the conditions within the current sheet above eruptive active regions.
    Keywords: Astronomy
    Type: M14-3685 , American Astronomical Society (AAS) Meeting; Jun 01, 2014 - Jun 05, 2014; Boston, MA; United States
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  • 50
    Publication Date: 2019-07-19
    Description: Chromosomal translocations and inversions are considered stable, and cells containing these types of chromosome aberrations can survive multiple cell divisions. An efficient method to detect an inversion is multi-color banding fluorescent in situ hybridization (mBAND) which allows identification of both inter- and intrachromosome aberrations simultaneously. Post irradiation, chromosome aberrations may also arise after multiple cell divisions as a result of genomic instability. To investigate the stable or late-arising chromosome aberrations induced after radiation exposure, we exposed human lymphocytes to gamma rays and Fe ions ex vivo, and cultured the cells for multiple generations. Chromosome aberrations were analyzed in cells collected at first mitosis and at several time intervals during the culture period post irradiation. With gamma irradiation, about half of the damages observed at first mitosis remained after 7 day- and 14 day- culture, suggesting the transmissibility of damages to the surviving progeny. Detailed analysis of chromosome break ends participating in exchanges revealed a greater fraction of break ends involved in intrachromosome aberrations in the 7- and 14-day samples in comparison to the fraction at first mitosis. In particular, simple inversions were found at 7 and 14 days, but not at the first mitosis, suggesting that some of the aberrations might be formed days post irradiation. In contrast, at the doses that produced similar frequencies of gamma-induced chromosome aberrations as observed at first mitosis, a significantly lower yield of aberrations remained at the same population doublings after Fe ion exposure. At these equitoxic doses, more complex type aberrations were observed for Fe ions, indicating that Fe ion-induced initial chromosome damages are more severe and may lead to cell death. Comparison between low and high doses of Fe ion irradiation in the induction of late damages will also be discussed.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30645 , COSPAR Scientific Assembly; Aug 02, 2014 - Aug 10, 2014; Moscow; Russia
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  • 51
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-19
    Description: RNA world theories figure prominently in many scenarios for the origin and early evolution of life. These theories posit that RNA molecules played a much larger role in ancient biology than they do now, acting both as the dominant biocatalysts and as the repository of genetic information. Many features of modern RNA biology are potential examples of molecular fossils from an RNA world, such as the pervasive involvement of nucleotides in coenzymes, the existence of natural aptamers that bind these coenzymes, the existence of natural ribozymes, a biosynthetic pathway in which deoxynucleotides are produced from ribonucleotides, and the central role of ribosomal RNA in protein synthesis in the peptidyl transferase center of the ribosome. Here, we uses both a top-down approach that evaluates RNA function in modern biology and a bottom-up approach that examines the capacities of RNA independent of modern biology. These complementary approaches exploit multiple in vitro evolution techniques coupled with high-throughput sequencing and bioinformatics analysis. Together these complementary approaches advance our understanding of the most primitive organisms, their early evolution, and their eventual transition to modern biochemistry.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13642 , Origins 2014 International Conference; Jul 06, 2014 - Jul 11, 2014; Nara; Japan
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  • 52
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-20
    Description: The Aviation Safety Reporting System (ASRS) in a partnership between the National Aeronautics and Space Administration (NASA), the Federal Aviation Administration (FAA), participating carriers, and labor organizations. It is designed to improve the National Airspace System by collecting and studying reports detailing unsafe conditions and events in the aviation industry. Employees are able to report safety issues or concerns with confidentiality and without fear of discipline. Safety reports highlighting fuel policies and alternate requirements for the aviation community highlight the human element in the complex aviation system.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13826 , Aviation Safety InfoShare; Mar 04, 2014; Seattle, WA; United States
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  • 53
    facet.materialart.
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    In:  CASI
    Publication Date: 2019-07-20
    Description: Project Overview: SporeSat is a fundamental space biology science space mission to investigate biophysical mechanisms of plant gravity sensing using a "lab-on-a-chip" experimental approach. The unicellular germinating Ceratopteris richardii fern spore will be studied in outer space. Science Objective: SporeSat shall determine gravity thresholds for calcium ion (Ca2+) channel activation in wild-fern spores. Why This is Important: Ion channels are critical to the functioning of biological organisms, including humans. Ion channels are key components of the nervous system as well as cardiac, skeletal, and smooth muscle function, transport of nutrients and ions, T-cell activation, and pancreatic beta-cell insulin release. Ion channels are often the target of the search for new drugs.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN15447 , Certamen Nacional "Misiones Espaciales Mexico"; May 29, 2014 - May 30, 2014; Mexico City; Mexico
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  • 54
    Publication Date: 2019-07-24
    Description: As does Earth, Mars presents pronounced global atmospheric circulation patterns. Solar differential heating drives mean meridional overturning (Hadley) circulations which are deep and intense, are hemispherically asymmetric, and where a cross-equatorial single cell dominates. Within middle and high latitudes, thermally indirect eddy-driven (Ferrel) circulation cells have been indicated. Differently, however, large-amplitude orography on planetary and continental scales on Mars can force very non-Earth-like hemispheric circulation patterns. Recent observations from the Mars Reconnaissance Orbiter, "Mars Color Imager" (MARCI) instrument are utilized that emphasize water ice clouds in ultra-violet (UV) wavelengths, and these measurements have been binned into "daily global maps" (DGMs) of water-ice cloud optical depth. The presence of large-scale, extratropical quasi-stationary atmospheric wave disturbances in middle and late winter of the northern hemisphere have been found to be present in such DGMs. In combination with such observations, a full-physics Mars global climate model (NASA ARC marsgcm 2.1) is applied to place the observations into context. During late northern winter, it is found that strong, forced Rossby modes (i.e., planetary waves) exist, and with direct correlation to columnintegrated cloud opacity undulating spatial patterns. At this season, zonal wavenumber s = 2 dominates (in contrast to wavenumber s = 1), consistent with MGS/TES analyses at this particular season (Banfield et al., 2003). Large-scale, planetary waves dictate the "coherence" of the northern polar vortex. Fundamentally, such forced planetary waves influence the polar vortex's impermeability (wave-induced) to tracer transport (e.g., dust and water-ice aerosol) and temporal mean water vapor spatial variations. The large-scale dynamical features of such planetary waves will be highlighted and discussed.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18963 , American Geophysical Union Fall 2014 Meeting; Dec 15, 2014 - Dec 19, 2014; San Francisco, CA; United States
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  • 55
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-24
    Description: Today Mars is a cold, dry, desert planet. The atmosphere is thin and liquid water is not stable at the surface. But there is evidence that very early in its history, some 3.7-4.1 billion years ago, the climate system supported much warmer conditions including an active hydrological cycle with rainfall and runoff. Given the importance of liquid water to astrobiology and NASAs Mars Exploration Program, researchers have been trying to understand the ancient martian climate system since the early 1970s when the Mariner 9 spacecraft first detected fluvial features on its oldest terrains. Though the evidence for warm wet conditions is compelling, the problem is not yet solved. The main issue is coping with the faint young sun. During the period when warmer conditions prevailed the suns luminosity was ~25% less than it is today. How can we explain the presence of liquid water on the surface of ancient Mars under such conditions? A similar problem exists for Earth, which would have frozen over under a faint sun even though the evidence suggests otherwise. Attempts to solve the Faint Young Sun Paradox, as it is commonly known, rely on greenhouse warming from an atmosphere with a different mass and composition than we see today. This is true for both Mars and Earth. However, for Mars there is no solution in sight. Long-lived continuously warm and wet atmospheres are difficult to produce and sustain. And a new and emerging idea - that ancient Mars was fundamentally a cold planet with transient episodes of warm wet conditions brought about by external forcings such as impacts, volcanism, and/or orbital changes also has issues. In this seminar I will review this fascinating topic and discuss some of the recent ideas on how to solve it, the issues they raise, and what I believe are some promising avenues for future research.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18544 , Scientific Seminar at Oregon State University; Nov 04, 2014; Corvallis, OR; United States
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  • 56
    Publication Date: 2019-07-20
    Description: Kepler-36 is an extreme planetary system, consisting of two transiting sub-Neptune-size planets orbiting around a sub-giant star with periods of 13.84 and 16.24 days. Mutual gravitational interactions between the two planets perturb the planets' transit times, allowing the planets' masses to be measured. Despite the similarity of their masses and orbital radii, the planets show a stark contrast in their mean densities: the inner planet (Kepler-36 b) is more than eight times as dense as its outer companion planet (Kepler-36 c). We perform a photo-dynamical analysis of the Kepler-36 system based on more than three years of Kepler photometry. With N-body integrations of initial conditions sampled from the photo-dynamical fits, we further refine the properties of the system by ruling out solutions that show large scale instability within 5 billion days. Ultimately, we measure the planets' masses with 4.2% precision and the planets' radii with 1.8% precision. Kepler-36 b is the rocky exoplanet with the most precisely measured mass and radius. Kepler-36 b's mass and radius are consistent with an Earth-like composition, whereas an iron-enhanced Mercury-like composition is ruled out.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN17623 , Annual Meeting of the Division for Planetary Sciences; Nov 09, 2014 - Nov 14, 2014; Tucson, AZ; United States
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  • 57
    Publication Date: 2019-07-20
    Description: Disk disperse in a few million years, before which they must form planets. Photoevaporation and viscosity are mainly responsible for disk dispersal. EUV, FUV and X-rays have all been suggested as photoevaporation agents, disk evolutionary scenarios and predicted mass loss rates in each case differ. Stellar mass and radiation field, disk properties, magnitude of viscosity, and dust evolution all play significant roles in determining the evolution of the disk and its lifetime. Observational diagnostics of photoevaperative flows include [Nell] and perhaps [OI]. These are at present inconclusive and better diagnostics are needed.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN17213 , The Disk in Relation to The Formation of Planets And Their Protoatmospheres; Aug 25, 2014 - Aug 29, 2014; Beijing; China
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  • 58
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-20
    Description: During spaceflight, astronauts experience weightlessness and are exposed to novel types of radiation. These environmental conditions may contribute to bone loss and reduction of structural integrity of the skeleton, which have negative implications for long-duration missions. The aim of this talk is to provide an overview of skeletal changes observed both in astronauts and in ground-based models of spaceflight, focusing on the fundamental biology and the prevention of deleterious skeletal changes.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN17133 , Ames Director''s Coloquim; Aug 05, 2014; Moffett Field, CA; United States
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  • 59
    Publication Date: 2019-07-20
    Description: DNA, RNA and proteins within a lipid-bound membrane are the core components of life, but the order of their appearance during the origin of life is still under debate. The widely accepted RNA World hypothesis states that RNA likely emerged prior to proteins and DNA since RNA can serve both replicative and catalytic roles. While biochemists have reproduced the synthesis, polymerization, and replication of nucleotides and RNA under controlled prebiotic conditions, it is clear that such complex organic molecules were are not present in significant amounts in the the starting prebiotic material on Earth either from endogenous production or meteoritic input. In contrast, amino acids are naturally abundant in various prebiotic contexts such as carbonaceous chondrites and Urey-Miller type experiments, and many studies have demonstrated that under plausible prebiotic conditions amino acids could condense or polymerize to give rise to short peptides. These findings support the basis of a Protein World hypothesis for life, however little has been done to study the functions of such primitive peptides. Here we present our novel synthetic biology-based approach to the de novo synthesis of billions of primitive peptidesproteins derived from a limited set of naturally abundant proteinogenic amino acids such as glycine, alanine, aspartic acid, glutamic acid, valine and serine. Of these peptides, the ones with divalent metal-binding capability are of particular interest and will be screened and identified. Certain divalent metals were likely present in prebiotic environments. Not only do they coordinate well with amino acids, but they also catalyze reactions, which are difficult to achieve in organic chemistry. Since D-chiral and non-proteinogenic amino acids are also abundant in the universe and may provide insight into the pathway by which life developed, we will also discuss methods to analyze primitive peptides consisting of these amino acids and D-chiral and non-proteinogenic amino acids. By understanding this naturalistic pathway, we will be able to better understand how life developed here on Earth. Since these amino acids are abundant in universe, this work provide insight into pathways by which life developed on Earth and, by extension, the probability of life arising elsewhere.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13514 , Origins 2014; Jul 06, 2014 - Jul 11, 2014; Nara; Japan
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  • 60
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    In:  CASI
    Publication Date: 2019-07-26
    Description: The rings are changing before our eyes; structure varies on all timescales and unexpected things have been discovered. Many questions have been answered, but some answers remain elusive. Here we highlight the major ring science progress over the mission to date, and describe new observations planned for Cassinis final three years. Ring Composition and particle sizes: The rings are nearly all water ice with no other ices so why are they reddish? The C Ring and Cassini Division are dirtier than the more massive B and A Rings, as shown by near- IR and, recently, microwave observations. Particle sizes, from stellar and radio occultation's, vary from place to place. Ring structure, micro and macro: numerous spiral density waves and ubiquitous self-gravity wakes reveal processes which fostered planet formation in the solar system and elsewhere. However, big puzzles remain regarding the main ring divisions, the C Ring plateau structures, and the B Ring irregular structure. Moonlets, inside and out, seen and unseen: Two gaps contain sizeable moonlets, but more gaps seem to contain none; even smaller embedded propeller objects wander, systematically or randomly, through the A ring. Rubble pile ring moons just outside the rings may escaped from the rings, and the recently discovered Peggy may be trying this as we watch. Impact bombardment of the rings: Comet fragments set the rings to rippling on century-timescales, and boulders crash through hourly; meanwhile, the constant hail of in falling Kuiper belt material has a lower mass flux than previously thought. Origin and Age of the Rings: The ring mass and bombardment play key roles. The ring mass is well known everywhere but in the B Ring (where most of it is). New models suggest how tidal breakup of evolving moons may have formed massive ancient rings, of which the current ring is just a shadow. During its last three years, the Cassini tour profile will allow entirely new observations: direct measurement of the still-unknown ring mass; direct in-situ sampling of ring particle composition (targeting the iron- or carbon based red non-icy component); and radar backscattering observations.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18917 , American Geophysical Union Fall 2014 Meeting; Dec 15, 2014 - Dec 19, 2014; San Francisco, CA; United States
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  • 61
    Publication Date: 2019-07-26
    Description: Xenon in Earth's atmosphere is severely mass fractionated and depleted compared to any plausible solar system source material, yet Kr is unfractionated. These observations seem to imply that Xe has escaped from Earth. But to date no process has been identified that can cause Xe, which is heavier than Kr, to escape while Kr does not. Vigorous hydrodynamic hydrogen escape can produce mass fractionation in heavy gases. The required hydrogen flux is very high but within the possible range permitted by solar Extreme Ultraviolet radiation (EUV, which here means radiation at wavelengths short enough to be absorbed efficiently by hydrogen) heating when Earth was on the order of 100 Myrs old or younger. However this model cannot explain why Xe escapes but Kr does not. Recently, what appears to be ancient atmospheric xenon has been recovered from several very ancient (3-3.5 Ga) terrestrial hydrothermal barites and cherts. What is eye-catching about this ancient Xe is that it is less fractionated that Xe in modern air. In other words, it appears that a process was active on Earth some 3 to 3.5 billion years ago that caused xenon to fractionate. By this time the Sun was no longer the EUV source that it used to. If xenon was being fractionated by escape currently the only viable hypothesis it had to be in the less unfamiliar context of Earths Archean atmosphere and under rather modest levels of EUV forcing. This requires a new model. Here we address the circumstances in which Xe, but not Kr, could escape from Earth as an ion. In a hydrodynamically escaping hydrogen wind the hydrogen is partially photo-ionized. The key concepts are that ions are much more strongly coupled to the escaping flow than are neutrals (so that a relatively modest flow of H and H+ to space could carry Xe+ along with it), and that xenon alone among the noble gases is more easily ionized than hydrogen. This sort of escape is possible if not prevented by a planetary magnetic field. The best prospects for Earth are therefore escape along the polar field lines, although a very weak or absent magnetic field would likely work as well. As applied to the Archean Earth the discussion will be constrained by diffusion-limited hydrogen escape. The extended history of hydrogen escape implicit in Xe escape in the Archean is consistent with suggestions that hydrogen escape from the anoxic Archean atmosphere was considerable, because biogenic methane is expected to have been rather abundant. Hydrogen escape plausibly played the key role in creating oxidizing condition at the surface of the Earth and setting the stage for the creation of an O2 atmosphere.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18793 , American Geophysical Union Fall 2014; Dec 15, 2014 - Dec 19, 2014; San Francisco, CA; United States
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  • 62
    Publication Date: 2019-07-26
    Description: The Mojave Volatiles Prospector (MVP) project is a science-driven field program with the goal to produce critical knowledge for conducting robotic exploration of the Moon. MVP will feed science, payload, and operational lessons learned to the development of a real-time, short-duration lunar polar volatiles prospecting mission. MVP achieves these goals through a simulated lunar rover mission to investigate the composition and distribution of surface and subsurface volatiles in a natural and a priori unknown environment within the Mojave Desert, improving our understanding of how to find, characterize, and access volatiles on the Moon. The MVP field site is the Mojave Desert, selected for its low, naturally occurring water abundance. The Mojave typically has on the order of 2-6% water, making it a suitable lunar analog for this field test. MVP uses the Near Infrared and Visible Spectrometer Subsystem (NIRVSS), Neutron Spectrometer Subsystem (NSS), and a downward facing GroundCam camera on the KREX-2 rover to investigate the relationship between the distribution of volatiles and soil crust variation. Through this investigation, we mature robotic in situ instruments and concepts of instrument operations, improve ground software tools for real time science, and carry out publishable research on the water cycle and its connection to geomorphology and mineralogy in desert environments. A lunar polar rover mission is unlike prior space missions and requires a new concept of operations. The rover must navigate 3-5 km of terrain and examine multiple sites in in just ~6 days. Operational decisions must be made in real time, requiring constant situational awareness, data analysis and rapid turnaround decision support tools. This presentation will focus on the first science results and operational architecture findings from the MVP field deployment relevant to a lunar polar rover mission.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN18863 , American Geophysical Union Fall 2014 Meeting; Dec 15, 2014 - Dec 19, 2014; San Francisco, CA; United States
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  • 63
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-20
    Description: The Aviation Safety Reporting System (ASRS) in a partnership between the National Aeronautics and Space Administration (NASA), the Federal Aviation Administration (FAA), participating carriers, and labor organizations. It is designed to improve the National Airspace System by collecting and studying reports detailing unsafe conditions and events in the aviation industry. Employees are able to report safety issues or concerns with confidentiality and without fear of discipline.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13716 , Aviation Safety InfoShare; Mar 04, 2014; Seattle, WA; United States
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  • 64
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-20
    Description: Two presentations, a technical and a non-technical with information about the Kepler Mission. Includes graphics on the telescope, how it works, the planets it has found. The technical includes couple of slides on the software pipeline architecture that helps detect the planets using Kepler Data. None of the Kepler graphics are newly created. Except the About Me slide everything else has been borrowed from not one but several different presentations, ones that I deemed helpful to me while doing my talks.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN15041 , Kepler Talk; Jun 25, 2014; Jalgaon, Maharashtra State; India
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  • 65
    Publication Date: 2019-07-20
    Description: The Fruit Fly Lab is a hardware suite being designed to support research on the International Space Station (ISS) for use by the entire Drosophila research community. A validation mission will launch and return on SpaceX-5 in late 2014, followed by Principal Investigator-lead science flights thereafter. Space flight experiments are selected via peer-reviewed proposals open to the Drosophila community. The cassettes (containers) that will house the Drosophila cultures were successfully used to conduct an immunity study on the Space Shuttle. Results showed that the innate immune system of Drosophila melanogaster was affected by space flight with a reduction in phagocytosis function of plasmatocytes, changes in antimicrobial peptides and other gene expression levels, as well as changes in development of the animals. Scientific research topics that are of interest to NASA will be presented. Each cassette used to house the Drosophila has a removable food tray that can be replaced to sustain the growth of the culture, or can be transferred to another cassette, along with embryos and burrowed larvae, enabling multi-generational studies. The cassette can be frozen in the Minus Eighty Laboratory Freezer for ISS to preserve samples until post-flight analysis, expanding the applications of the hardware. Utilization of a centrifuge allows for on-orbit 1g controls for microgravity experiments, as well as variable g-levels for lunar or Mars environment studies. The standard form factor used also allows for implementation of modular upgrades. An observation system, circadian rhythm lighting system, and fixation capability are upgrades currently in development for near-term implementation. This hardware suite, with its flight- proven design and ability to utilize existing on-board facilities, offers the whole Drosophila research community a platform to address several key areas of the National Research Councils decadal survey, supporting the utilization of ISS for science discovery.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN13412 , Annual Drosophila Research Conference; Mar 26, 2014 - Mar 30, 2014; San Diego, CA; United States
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  • 66
    Publication Date: 2019-07-27
    Description: The Optical Measurements Group (OMG) within the NASA Orbital Debris Program Office (ODPO) addresses U.S. National Space Policy goals by monitoring and characterizing debris. Since 2001, the OMG has used the Michigan Orbital Debris Survey Telescope (MODEST) at Cerro Tololo Inter-American Observatory (CTIO) in Chile for general orbital debris surveys. The 0.6-m Schmidt MODEST provides calibrated astronomical data of GEO targets, both catalogued and uncatalogued debris, with excellent image quality. The data are utilized by the ODPO modeling group and are included in the Orbital Debris Engineering Model (ORDEM) v. 3.0. MODEST and the CTIO/SMARTS (Small and Moderate Aperture Research Telescope System) 0.9 m are both employed to acquire filter photometry data as well as synchronously observe targets in selected optical filters. Obtaining data synchronously yields data for material composition studies as well as longer orbital arc data on the same target without time delay or bias from a rotating, tumbling, or spinning target. Observations of GEO orbital debris using the twin 6.5-m Magellan telescopes at Las Campanas Observatory in Chile for deep imaging (Baade) and spectroscopic data (Clay) began in 2011. Through the data acquired on Baade, debris has been detected that reaches approx. 3 magnitudes fainter than detections with MODEST, while the spectral data from Clay provide better resolved information used in material characterization analyses. To better characterize and model optical data, the Optical Measurements Center (OMC) at NASA/JSC has been in operation since 2005, resulting in a database of comparison laboratory data. The OMC is designed to emulate illumination conditions in space using equipment and techniques that parallel telescopic observations and sourcetarget- sensor orientations. Lastly, the OMG is building the Meter Class Autonomous Telescope (MCAT) at Ascension Island. The 1.3-m telescope is designed to observe GEO and LEO targets, using a modified Ritchey-Chrtien configuration on a double horseshoe equatorial mount to allow tracking objects at LEO rates through the dome's keyhole at zenith. Through the data collection techniques employed at these unique facilities, NASA's ODPO has developed a multifaceted approach to characterize the orbital debris risk to satellites in various altitudes and provide insight leading toward material characterization of debris via photometric and spectroscopic measurements. Ultimately, the data are used in conjunction with in-situ and radar measurements to provide accurate data for models of our space environment and for facilitating spacecraft risk assessment.
    Keywords: Astronomy
    Type: PaperID: 7106936 , JSC-CN-31931 , AMOS Technologies Conference 2014; 9-12 Sept. 2014; Maui, HI; United States
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  • 67
    Publication Date: 2019-08-24
    Description: The realization of a large, space-based 10 meter class telescope for far-infrared/THz studies has long been a goal of NASA. Such a telescope could study the origins of stars, planets, molecular clouds, and galaxies; providing a much needed means of following-up on tantalizing results from recent successful missions such as Spitzer, Herschel, and SOFIA. Indeed, Herschel began its life in the US space program as the Large Deployable Reflector (LDR) to be assembled in low Earth orbit by shuttle astronauts. Escalating costs and smaller federal budget allocations resulted in a downsizing of the mission. However, by combining successful suborbital balloon and ground-based telescope technologies, the dream of a 10 meter class telescope free of ~99% of the Earth's atmospheric absorption in the far-infrared can be realized. The same telescope can also be used to perform sensitive, high spectral and spatial resolution limb sounding studies of the Earth's atmosphere in greenhouse gases such as CO, ClO, O3, and water, as well as serve as a high flying hub for any number of telecommunications and surveillance activities. Flight times of 100+ days will be possible, with instruments having mass and power requirements in excess of ~500 kg and ~1 kW.Here we present the results of our NIAC Step 1, Phase B design study where each key aspect of the LBR concept is discussed and recommendations made for further study in Phase II.These aspects include realization of a large spherical reflecting surface, spherical corrector, pointing system, instrument module, and service module/gondola. Once each hardware component is introduced, a typical LBR Mission profile is described that enables the realization of a stratospheric 10 meter THz observatory and limb sounder. Verification of the design approach was achieved by using a combination of analytical modelling, lab testing of materials and techniques, and building a 3 meter rooftop LBR prototype.
    Keywords: Astronomy
    Type: HQ-E-DAA-TN63093
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  • 68
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-12
    Description: The 2013 Nutrition Risk Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on November 20 - 21, 2013. The SRP reviewed the new Evidence Report for the Risk Factor of Inadequate Nutrition (from here on referred to as the 2013 Nutrition Evidence Report), as well as the Research Plan for this Risk. Overall, the SRP thinks the well-qualified research team has compiled an excellent summary of background information in the 2013 Nutrition Evidence Report. The SRP would like to commend the authors in general and particularly note that while the 2013 Nutrition Evidence Report has been written using a single nutrient approach, the research plan takes a much more integrated and physiologically based approach.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30328
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  • 69
    Publication Date: 2019-07-12
    Description: On December 5, 2013, the Pharmacology Risk SRP, participants from the JSC, HQ, the NSBRI, and NRESS participated in a WebEx/teleconference. The purpose of the call (as stated in the Statement of Task) was to allow the SRP members to: 1. Receive an update by the HRP Chief Scientist or Deputy Chief Scientist on the status of NASA's current and future exploration plans and the impact these will have on the HRP. 2. Receive an update on any changes within the HRP since the 2012 SRP meeting. 3. Receive an update by the Element or Project Scientist(s) on progress since the 2012 SRP meeting. 4. Participate in a discussion with the HRP Chief Scientist, Deputy Chief Scientist, and the Element regarding possible topics to be addressed at the next SRP meeting.
    Keywords: Life Sciences (General)
    Type: JSC-CN-30327
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  • 70
    Publication Date: 2019-07-12
    Description: We study the relationship between the structure and star-formation rate (SFR) of X-ray selected low and moderate luminosity active galactic nuclei (AGNs) in the two Chandra Deep Fields, using Hubble Space Telescope imaging from the Cosmic Assembly Near Infrared Extragalactic Legacy Survey (CANDELS) and deep far-infrared maps from the PEP+GOODS-Herschel survey. We derive detailed distributions of structural parameters and FIR luminosities from carefully constructed control samples of galaxies, which we then compare to those of the AGNs. At z is approximately 1, AGNs show slightly diskier light profiles than massive inactive (non-AGN) galaxies, as well as modestly higher levels of gross galaxy disturbance (as measured by visual signatures of interactions and clumpy structure). In contrast, at z 2, AGNs show similar levels of galaxy disturbance as inactive galaxies, but display a red central light enhancement, which may arise due to a more pronounced bulge in AGN hosts or due to extinguished nuclear light. We undertake a number of tests of both these alternatives, but our results do not strongly favour one interpretation over the other. The mean SFR and its distribution among AGNs and inactive galaxies are similar at z greater than 1.5. At z less than 1, however, clear and significant enhancements are seen in the SFRs of AGNs with bulge-dominated light profiles. These trends suggest an evolution in the relation between nuclear activity and host properties with redshift towards a minor role for mergers and interactions at z greater than 15
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN19052
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  • 71
    Publication Date: 2019-07-12
    Description: This paper reports the results from three targeted searches of Milagro TeV sky maps: two extragalactic point source lists and one pulsar source list. The first extragalactic candidate list consists of 709 candidates selected from the Fermi-LAT 2FGL catalog. The second extragalactic candidate list contains 31 candidates selected from the TeVCat source catalog that have been detected by imaging atmospheric Cherenkov telescopes (IACTs). In both extragalactic candidate lists Mkn 421 was the only source detected by Milagro. This paper presents the Milagro TeV flux for Mkn 421 and flux limits for the brighter Fermi- LAT extragalactic sources and for all TeVCat candidates. The pulsar list extends a previously published Milagro targeted search for Galactic sources. With the 32 new gamma-ray pulsars identified in 2FGL, the number of pulsars that are studied by both Fermi-LAT and Milagro is increased to 52. In this sample, we find that the probability of Milagro detecting a TeV emission coincident with a pulsar increases with the GeV flux observed by the Fermi-LAT in the energy range from 0.1 GeV to 100 GeV.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN23133
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  • 72
    facet.materialart.
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    In:  CASI
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Astronomy
    Type: M15-4156
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  • 73
    Publication Date: 2019-08-13
    Description: Based on previously reported procedures for permeabilizing vegetative bacterial cells, and numerous trial-and-error attempts with bacterial endospores, a protocol was developed for effectively permeabilizing bacterial spores, which facilitated the applicability of fluorescent in situ hybridization (FISH) microscopy. Bacterial endospores were first purified from overgrown, sporulated suspensions of B. pumilus SAFR-032. Purified spores at a concentration of approx equals 10 million spores/mL then underwent proteinase-K treatment, in a solution of 468.5 L of 100 mM Tris-HCl, 30 L of 10% SDS, and 1.5 microL of 20 mg/mL proteinase-K for ten minutes at 35 C. Spores were then harvested by centrifugation (15,000 g for 15 minutes) and washed twice with sterile phosphate-buffered saline (PBS) solution. This washing process consisted of resuspending the spore pellets in 0.5 mL of PBS, vortexing momentarily, and harvesting again by centrifugation. Treated and washed spore pellets were then resuspended in 0.5 mL of decoating solution, which consisted of 4.8 g urea, 3 mL Milli-Q water, 1 mL 0.5M Tris, 1 mL 1M dithiothreitol (DTT), and 2 mL 10% sodium-dodecylsulfate (SDS), and were incubated at 65 C for 15 minutes while being shaken at 165 rpm. Decoated spores were then, once again, washed twice with sterile PBS, and subjected to lysozyme/mutanolysin treatment (7 mg/mL lysozyme and 7U mutanolysin) for 15 minutes at 35 C. Spores were again washed twice with sterile PBS, and spore pellets were resuspended in 1-mL of 2% SDS. This treatment, facilitating inner membrane permeabilization, lasted for ten minutes at room temperature. Permeabilized spores were washed two final times with PBS, and were resuspended in 200 mkcroL of sterile PBS. At this point, the spores were permeable and ready for downstream processing, such as oligonucleotideprobe infiltration, hybridization, and microscopic evaluation. FISH-microscopic imagery confirmed the effective and efficient (50% successful permeabilization and recovery) permeabilization of numerous spore preparations. The novelty of the technology developed here is in its applicability to bacterial endospores. While protocols abound for the effective permeabilization of bacterial, archaeal, and eukaryotic vegetative cells, there are no such reliable methods for decoating and permeabilizing bacterial endospores in a manner that is amenable to downstream FISH microscopic analyses. This innovation enables the direct visualization and enumeration of spores via FISH-based microscopic techniques, circumventing the complications that accompany previously required germination regimes. The synergistic enzymatic weakening of the many spore layers facilitates a structural compromise that is just enough to render the spores permeable without degrading the spore to a level, which precludes it from recognition.
    Keywords: Life Sciences (General)
    Type: NPO-48035 , NASA Tech Briefs, January 2014; 13
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  • 74
    Publication Date: 2019-08-13
    Description: RNA isolation is a ubiquitous need, driven by current emphasis on microarrays and miniaturization. With commercial systems requiring 100,000 to 1,000,000 cells for successful isolation, there is a growing need for a small-footprint, easy-to-use device that can harvest nucleic acids from much smaller cell samples (1,000 to 10,000 cells). The process of extraction of RNA from cell cultures is a complex, multi-step one, and requires timed, asynchronous operations with multiple reagents/buffers. An added complexity is the fragility of RNA (subject to degradation) and its reactivity to surface. A novel, microfluidics-based, integrated cartridge has been developed that can fully automate the complex process of RNA isolation (lyse, capture, and elute RNA) from small cell culture samples. On-cartridge cell lysis is achieved using either reagents or high-strength electric fields made possible by the miniaturized format. Traditionally, silica-based, porous-membrane formats have been used for RNA capture, requiring slow perfusion for effective capture. In this design, high efficiency capture/elution are achieved using a microsphere-based "microfluidized" format. Electrokinetic phenomena are harnessed to actively mix microspheres with the cell lysate and capture/elution buffer, providing important advantages in extraction efficiency, processing time, and operational flexibility. Successful RNA isolation was demonstrated using both suspension (HL-60) and adherent (BHK-21) cells. Novel features associated with this development are twofold. First, novel designs that execute needed processes with improved speed and efficiency were developed. These primarily encompass electric-field-driven lysis of cells. The configurations include electrode-containing constructs, or an "electrode-less" chip design, which is easy to fabricate and mitigates fouling at the electrode surface; and the "fluidized" extraction format based on electrokinetically assisted mixing and contacting of microbeads in a shape-optimized chamber. A secondary proprietary feature is in the particular layout integrating these components to perform the desired operation of RNA isolation. Apart from a novel functional capability, advantages of the innovation include reduced or eliminated use of toxic reagents, and operator-independent extraction of RNA.
    Keywords: Life Sciences (General)
    Type: MSC-24375-1 , NASA Tech Briefs, January 2014; 13-14
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  • 75
    Publication Date: 2019-08-13
    Description: Long-term spaceflight causes profound changes to the musculoskeletal system attributable to unloading and fluid shifts in microgravity. Future space explorations beyond the earths magnetosphere will expose astronauts to space radiation, which may cause additional skeletal deficits that are not yet fully understood. Our long-term goals are twofold: to define the mechanisms and risk of bone loss in the spaceflight environment and to facilitate the development of effective countermeasures if necessary. Our central hypothesis is that oxidative stress plays a key role in progressive bone loss and vascular dysfunction caused by spaceflight. In animals models, overproduction of free radicals is associated with increased bone resorption, lower bone formation, and decrements in bone mineral density and structure which can ultimately lead to skeletal fragility. Evidence in support of a possible causative role for oxidative stress in spaceflight-induced bone loss derive from knockout and transgenic mouse studies and the use of pharmacological interventions with known anti-oxidant properties. In our studies to simulate spaceflight, 16-wk old, male C56Bl/6J mice were assigned to one of four groups: hind limb unloading to simulate weightlessness (HU), normally loaded Controls (NL) (sham irradiated, no hind limb unloading), irradiated at NASA Space Radiation Laboratory IR with 1-2Gy of (600MeV/n) alone, or in combination with protons (0.5Gy Protons/0.5Gy 56Fe), (IR) or both hind limb unloaded and irradiated, HU+IR. Mice were exposed to radiation 3 days after initiating HU and tissues harvested were 1-14 days after initiating treatments for analyses. Results from our laboratories, which employ various biochemical, gene expression, functional, and transgenic animal model methods, implicate dynamic regulation of redox-related pathways by spaceflight-related environmental factors. As one example, we found that combined HU and radiation exposure caused oxidative damage in skeletal tissues (lipid peroxidation) of wildtype mice, whereas bone from transgenic mice that overexpress human catalase in mitochondria were protected. Interestingly, marrow cells grown under culture conditions that select for endothelial progenitor cells (EPC), showed that HU but not IR reduced EPC cell migration; in contrast HU and IR each inhibited growth of marrow-derived osteoblast progenitors. Taken together, these results indicate that unloading and ionizing elicit distinct effects on progenitor and mature cells of vascular and skeletal tissue, and that oxidative damage may contribute to skeletal and vascular deficits that may emerge during extended space travel.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN18527 , Human Research Program Investigators'' Workshop; Feb 12, 2014 - Feb 13, 2014; Galveston, TX; United States
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  • 76
    Publication Date: 2019-08-13
    Description: Research using rodents is an essential tool for advancing biomedical research on Earth and in space. The National Research Counsels Decadal survey (1) emphasized the importance of expanding NASAs life sciences research to perform long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, flight hardware, operations, and science capabilities were developed at NASA ARC to support both commercial and government-sponsored research. In preparation for the maiden voyage of the Rodent Habitat hardware and operations system (Rodent Research-1), and in close consultation with a Science Working Group comprised of veterinarians and experienced spaceflight investigators, we modified existing Animal Enclosure Module hardware, developed new hardware, operations, and science activities, and performed a series of ground-based verification tests. Preflight, ground based hardware tests included a simulation of SpaceX Dragon launch conditions (vibration and hypergravity) using the Transporter, and also two long-term biocompatibility tests (32 and 92 days) using the Habitat developed for long term housing on the ISS. The launch simulation test showed that adult mice housed in Transporter hardware adapted well, even if launch simulation was followed by a period of simulated weightlessness (via hind limb unloading). The biocompatibility tests demonstrated that the Habitat successfully supported animal health and also provided a useful video imaging system that enables frequent monitoring of animal health and behavior by veterinary and scientific experts on the ground, independent of ISS crew intervention. At the conclusion of all tests, mice were deemed healthy and suitable for conducting biological research. Additional preflight analyses of tissues preserved by freezing or fixation for gene expression analyses revealed that spleen and liver tissues recovered under conditions that simulated on-orbit activities yielded high quality RNA (RIN values 8-10) and liver enzyme activities and protein content (e.g. catalase). In addition, new methods were developed to optimize future science return by dissecting tissues post-euthanasia and storage. Various tissues were harvested from either intact or partially dissected, frozen carcasses after storage for ~2-6 months; most of the tissues (brain, heart, kidney, eye, adrenal glands and skeletal muscle) were of high RNA quality for science return, whereas some tissues (small intestine, bone marrow and bones) were not. These data demonstrated the protocols developed for future flight experiments supported science return despite delayed preservation post-euthanasia or prolonged storage, and furthermore, that high-quality RNA samples from many different tissues can be recovered by dissection following prolonged storage of the tissue in situ at -80C. The first flight experiments carrying 20 mice were launched on Sept 21, 2014 in an unmanned Dragon Capsule, SpaceX4; Rodent Research-1 is dedicated to achieving both NASA validation and CASIS science objectives. Ground based control groups (housed in flight hardware or standard cages) were maintained in environmental chambers at Kennedy Space Center. Crewmembers previously trained in animal handling transferred mice from the Transporter into Habitats under simultaneous veterinary supervision by video streaming and were deemed healthy. Health and behavior of all mice on the ISS was monitored by video feed on a daily basis. The 10 mice for validation (16wk old, female C57Bl6/J) ambulated freely and actively throughout the Habitat, relying heavily on their forelimbs for locomotion. The first on-orbit dissections of mice were performed successfully on Oct 12 and 13, 2014, and the validation mice will reside on ISS for up to 30 days. In conclusion, new capability for long duration rodent research is under development, including in-flight sample collection (which avoids the complication of reentry); results obtained to date will be described. This new Rodent Research system enables achievement of both basic science and translational research objectives to advance human exploration of space.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN18479 , Human Research Program Investigators Workshop; Feb 12, 2014 - Feb 13, 2014; Galveston, TX; United States
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  • 77
    Publication Date: 2019-08-13
    Description: Long-term spaceflight leads to extensive changes in the musculoskeletal system attributable, in part, to unloading during microgravity exposure. Additionally, irradiation at doses similar to that of a solar flare or a round-trip sojourn to Mars may cause significant depletion of stem/progenitor cell pools throughout the body as well as inflammation associated with prompt skeletal-tissue degradation. Previously, we demonstrated that irradiation leads to rapid bone loss, which can be mitigated in the short term by injection of a potent antioxidant (-lipoic acid). Furthermore, simulated weightlessness in adult mice adversely affects skeletal responses to low linear energy transfer (LET) radiation (137Cs). Here, we hypothesized that simulated weightlessness exacerbates the adverse effects of simulated space radiation (including both protons and 56Fe ions) by adversely affecting skeletal structure and functions as well as associated vasculature. Furthermore, we hypothesized that an antioxidant cocktail, which has been shown to be protective in other tissues, mitigates space radiation induced bone loss.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN12029 , NASA Human Research Program Investigators'' Workshop (HRP 2014); Feb 12, 2014 - Feb 13, 2014; Glaveston, TX; United States
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  • 78
    Publication Date: 2019-08-13
    Description: Alterations and impairment of immune responses in humans present a health risk for space exploration missions. The molecular mechanisms under pinning innate immune defense can be confounded by the complexity of the acquired immune system of humans. Drosophila (fruit fly) innate immunity is simpler, and shares many similarities with human innate immunity at the level of molecular and genetic pathways. The goals of this study were to elucidate fundamental immune processes in Drosophila affected by spaceflight and to measure host-pathogen responses post-flight. Five containers, each containing ten female and five male fruit flies, were housed and bred on the space shuttle (average orbit altitude of330.35 km) for 12 days and 18.5 hours. A new generation of flies was reared in microgravity. In larvae, the immune system was examined by analyzing plasmatocyte number and activity in culture. In adults, the induced immune responses were analyzed by bacterial clearance and quantitative real-time polymerase chain reaction (qPCR) of selected genes following infection with E. coli. The RNA levels of relevant immune pathway genes were determined in both larvae and adults by microarray analysis. The ability of larval plasmatocytes to phagocytose E. coli in culture was attenuated following spaceflight, and in parallel, the expression of genes involved in cell maturation was down regulated. In addition, the level of constitutive expression of pattern recognition receptors and opsonins that specifically recognize bacteria, and of lysozymes, antimicrobial peptide (AMP) pathway and immune stress genes, hallmarks of humoral immunity, were also reduced in larvae. In adults, the efficiency of bacterial clearance measured in vivo following a systemic infection with E. coli post-flight, remained robust. We show that spaceflight altered both cellular and humoral immune responses in Drosophila and that the disruption occurs at multiple interacting pathways.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN12039 , NASA Human Research Program Investigators'' Workshop (HRP 2014); Feb 12, 2014 - Feb 13, 2014; Glaveston, TX; United States
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  • 79
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    Unknown
    In:  CASI
    Publication Date: 2019-08-28
    Description: A method of measuring motion blur is disclosed comprising obtaining a moving edge temporal profile r(sub 1)(k) of an image of a high-contrast moving edge, calculating the masked local contrast m(sub1)(k) for r(sub 1)(k) and the masked local contrast m(sub 2)(k) for an ideal step edge waveform r(sub 2)(k) with the same amplitude as r(sub 1)(k), and calculating the measure or motion blur Psi as a difference function, The masked local contrasts are calculated using a set of convolution kernels scaled to simulate the performance of the human visual system, and Psi is measured in units of just-noticeable differences.
    Keywords: Life Sciences (General)
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  • 80
    Publication Date: 2019-11-06
    Description: Mars reveals similar, yet also rather different, atmospheric circulation patterns compared to those on Earth. In both atmospheres, solar differential heating drives global Hadley circulation cells. However during solstice on Mars, its Hadley cells are hemispherically asymmetric: an intense, deep, cross-hemisphere single cell dominates with rising motion in the summer hemisphere and sinking motion in the winter hemisphere. Both planets also exhibit thermally indirect (i.e., eddy-driven) Ferrel circulation cells in middle and high latitudes. In addition, Earth and Mars exhibit distinctive large-scale orography and, in a broadly defined context, continentality. For Mars northern midlatitudes, Tharsis in the western hemisphere, and Arabia Terra and Elysium in the eastern hemisphere, are the primary large-scale topographic features. In the southern-midlatitudes, Tharsis and Argyre in the western hemisphere, and Hellas in the eastern hemisphere are the key topographic features which can influence large-scale circulation patterns. Such underlying orographic complexes not only cause significant latitudinal excursions of the seasonal mean westerly circumnavigating polar vortex but also significantly modulate the intensity and preferred geographic regions of traveling baroclinic weather systems.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN15068 , International Conference on Mars; Jul 14, 2014 - Jul 18, 2014; Pasadena, CA; United States
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  • 81
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Astronomy
    Type: International Conference on Space Operations (SpaceOps 2014); May 05, 2016 - May 09, 2016; Pasadena, CA; United States
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  • 82
    Publication Date: 2019-07-13
    Description: We report on multifrequency observations performed during 2012 December-2013 August of the first narrow-line Seyfert 1 galaxy detected in gamma rays, PMN J0948+0022 (z equal to 0.5846). A gamma-ray flare was observed by the Large Area Telescope on board Fermi during 2012 December-2013 January, reaching a daily peak flux in the 0.1-100 GeV energy range of (155 plus or minus 31)10(exp 8) ph cm (exp 2) s (exp 1) on 2013 January 1, corresponding to an apparent isotropic luminosity of approximately 1.510)exp 48) erg s(exp 1). The gamma-ray flaring period triggered Swift and VERITAS observations in addition to radio and optical monitoring by OVRO, MOJAVE, and CRTS. A strong flare was observed in optical, UV, and X- rays on 2012 December 30, quasi-simultaneously to the gamma-ray flare, reaching a record flux for this source from optical to gamma rays. VERITAS observations at very high energy (E greater than 100 GeV) during 2013 January 6-17 resulted in an upper limit of F(sub greater than 0.2 TeV) less than 4.0 10(exp 12) ph cm(exp 2) s(exp 1). We compared the spectral energy distribution (SED) of the flaring state in 2013 January with that of an intermediate state observed in 2011. The two SEDs, modelled as synchrotron emission and an external Compton scattering of seed photons from a dust torus, can be modelled by changing both the electron distribution parameters and the magnetic field.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN24339 , Monthly Notices of the Royal Astronomical Society (ISSN 0035-8711) (e-ISSN 1365-2966); 446; 3; 2456-2467
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  • 83
    Publication Date: 2019-07-13
    Description: On September 21-22, 2013, the High Energy Replicated Optics to Explore the Sun (HEROES) hard X-ray telescope, flew as a balloon payload from Ft. Sumner, N.M. HEROES observed the Sun, the black hole binary GRS 1915+105, and the Crab Nebula during its 27 hour flight. In this paper we describe laboratory calibration measurements of the HEROES detectors using line and continuum sources, applications of these measurements to define channel to energy (gain) corrections for observed events and to define detector response matrices. We characterize the HEROES X-ray grazing incidence optics using measurements taken in the Stray-Light (SLF) Facility in Huntsville, AL, and using ray traces.
    Keywords: Astronomy
    Type: M14-3875 , Journal of Astronomical Instrumentation; 3; 2
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  • 84
    Publication Date: 2019-07-13
    Description: We present an analysis of the diffuse X-ray emission in 19 compact groups (CGs) of galaxies observed with Chandra. The hottest, most X-ray luminous CGs agree well with the galaxy cluster X-ray scaling relations in L(x-T) and (L(x-sigma), even in CGs where the hot gas is associated with only the brightest galaxy. Using Spitzer photometry, we compute stellar masses and classify Hickson CGs 19, 22, 40, and 42, and RSCGs 32, 44, and 86 as fossil groups using a new definition for fossil systems that includes a broader range of masses. We find that CGs with total stellar and Hi masses are great than or equal to 10(sup (11.3) solar mass are often X-ray luminous, while lower-mass CGs only sometimes exhibit faint, localized X-ray emission. Additionally, we compare the diffuse X-ray luminosity against both the total UV and 24 micron star formation rates of each CG and optical colors of the most massive galaxy in each of the CGs. The most X-ray luminous CGs have the lowest star formation rates, likely because there is no cold gas available for star formation, either because the majority of the baryons in these CGs are in stars or the X-ray halo, or due togas stripping from the galaxies in CGs with hot halos. Finally, the optical colors that trace recent star formation histories of the most massive group galaxies do not correlate with the X-ray luminosities of the CGs, indicating that perhaps the current state of the X-ray halos is independent of the recent history of stellar mass assembly in the most massive galaxies.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN23809 , The Astrophysical Journal; 790; 2; 132
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  • 85
    Publication Date: 2019-07-13
    Description: We report on Hubble Space Telescope (HST) observations of three Kuiper Belt Objects (KBOs), discovered in our dedicated ground-based search campaign, that are candidates for long-range observations from the New Horizons spacecraft: 2011 epochY31, 2011 HZ102, and 2013 LU35. Astrometry with HST enables both current and future critical accuracy improvements for orbit precision, required for possible New Horizons observations, beyond what can be obtained from the ground. Photometric colors of all three objects are red, typical of the Cold Classical dynamical population within which they reside; they are also the faintest KBOs to have had their colors measured. None are observed to be binary with HST above separations of approx. 0.02 arcsec (approx. 700 km at 44 AU) and delta m less than or equal to 0.5.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN22030 , Icarus; 246; 15; 369-374
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  • 86
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: JSC-CN-32010
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  • 87
    Publication Date: 2019-07-12
    Description: A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.
    Keywords: Life Sciences (General)
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  • 88
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    Unknown
    In:  CASI
    Publication Date: 2019-07-12
    Description: Provided herein are an isolated or enriched population of tumor initiating cells derived from normal cells, cells susceptible to neoplasia, or neoplastic cells. Methods of use of the cells for screening for anti-hyperproliferative agents, and use of the cells for animal models of hyperproliferative disorders including metastatic cancer, diagnostic methods, and therapeutic methods are provided.
    Keywords: Life Sciences (General)
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  • 89
    Publication Date: 2019-07-12
    Description: Recently, a parallel pathway model to describe ankle dynamics was proposed. This model provides a relationship between ankle angle and net ankle torque as the sum of a linear and nonlinear contribution. A technique to identify parameters of this model in discrete-time has been developed. However, these parameters are a nonlinear combination of the continuous-time physiology, making insight into the underlying physiology impossible. The stable and accurate estimation of continuous-time parameters is critical for accurate disease modeling, clinical diagnosis, robotic control strategies, development of optimal exercise protocols for longterm space exploration, sports medicine, etc. This paper explores the development of a system identification technique to estimate the continuous-time parameters of ankle dynamics. The effectiveness of this approach is assessed via simulation of a continuous-time model of ankle dynamics with typical parameters found in clinical studies. The results show that although this technique improves estimates, it does not provide robust estimates of continuous-time parameters of ankle dynamics. Due to this we conclude that alternative modeling strategies and more advanced estimation techniques be considered for future work.
    Keywords: Life Sciences (General)
    Type: NASA/TM-2014-218314 , DFRC-E-DAA-TN14535
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  • 90
    Publication Date: 2019-07-12
    Description: Mitigate microbial risk to crew health, safety, and performance during the human exploration of space
    Keywords: Life Sciences (General)
    Type: JSC-CN-31814
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  • 91
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: JSC-CN-31812
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  • 92
    Publication Date: 2019-07-12
    Description: No abstract available
    Keywords: Life Sciences (General)
    Type: JSC-CN-31683
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  • 93
    Publication Date: 2019-07-12
    Description: Spatially resolved scattered-light images of circumstellar debris in exoplanetary systems constrain the physical properties and orbits of the dust particles in these systems. They also inform on co-orbiting (but unseen) planets, the systemic architectures, and forces perturbing the starlight-scattering circumstellar material. Using HST/STIS broadband optical coronagraphy, we have completed the observational phase of a program to study the spatial distribution of dust in a sample of ten circumstellar debris systems, and one "mature" protoplanetrary disk all with HST pedigree, using PSF-subtracted multi-roll coronagraphy. These observations probe stellocentric distances greater than or equal to 5 AU for the nearest systems, and simultaneously resolve disk substructures well beyond corresponding to the giant planet and Kuiper belt regions within our own Solar System. They also disclose diffuse very low-surface brightness dust at larger stellocentric distances. Herein we present new results inclusive of fainter disks such as HD92945 (F (sub disk) /F (sub star) = 5x10 (sup -5) confirming, and better revealing, the existence of a narrow inner debris ring within a larger diffuse dust disk. Other disks with ring-like sub-structures and significant asymmetries and complex morphologies include: HD181327 for which we posit a spray of ejecta from a recent massive collision in an exo-Kuiper belt; HD61005 suggested to be interacting with the local ISM; HD15115 and HD32297, discussed also in the context of putative environmental interactions. These disks, and HD15745, suggest that debris system evolution cannot be treated in isolation. For AU Mic's edge-on disk we find out-of-plane surface brightness asymmetries at greater than or equal to 5 AU that may implicate the existence of one or more planetary perturbers. Time resolved images of the MP Mus proto-planetary disk provide spatially resolved temporal variability in the disk illumination. These and other new images from our HST/STIS GO/12228 program enable direct inter-comparison of the architectures of these exoplanetary debris systems in the context of our own Solar System.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN16483
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  • 94
    Publication Date: 2019-07-12
    Description: The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve.
    Keywords: Life Sciences (General)
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  • 95
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2019-07-12
    Description: We propose to develop a national center of excellence in Regolith Radiative Transfer (RRT), i.e., in modeling spectral reflectivity and emissivity of grainy or structured surfaces. The focus is the regime where the structural elements of grainy surfaces have grain sizes and separations of tens of microns, comparable to the wavelengths carrying diagnostic compositional information. This regime is of fundamental interest to remote sensing of planetary and terrestrial surfaces.
    Keywords: Astronomy
    Type: ARC-E-DAA-TN15014
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  • 96
    Publication Date: 2019-07-13
    Description: The article Measuring the Hubble constant by Mario Livio and Adam Riess (Physics Today, October 2013, page 41) reviewed studies of the expanding universe from the 1920s to the present. Although the history of the subject underwent considerable compression to fit the length of a magazine article, we think it may leave a misleading impression of some of the key steps to our current understanding. We therefore offer the following clarifications. Most significantly, papers by Arthur Eddington and by Willem de Sitter in 1930, who successfully promoted Georges Lematres 1927 article for the Scientific Society of Brussels, effected a paradigm shift in interpretation of extragalactic redshifts in 1930. Before then, the astronomical community was generally unaware of the existence of nonstatic cosmological solutions and did not broadly appreciate that redshifts could be thought of locally as Doppler shifts in an expanding matter distribution. Certainly, in 1929 Edwin Hubble referred only to the de Sitter solution of 1917. At the time, the relation between distance and redshift predicted in that model was generally seen purely as a manifestation of static spacetime curvature.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN18347 , Physics Today; 67; 7; 8
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  • 97
    Publication Date: 2019-07-13
    Description: Photosynthetic and growth data were collected on APH Root Module. Described Stand pipe system for active moisture control. Tested germination in wicks. Evaluated EC-5 moisture sensors. Demonstrated that Wheat plants can grow in the APH Root Module.
    Keywords: Life Sciences (General)
    Type: KSC-E-DAA-TN18441 , American Society for Gravitational and Space Research; Oct 22, 2014 - Oct 26, 2014; Pasadena CA; United States
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  • 98
    Publication Date: 2019-07-13
    Description: We present a spectral analysis of three simultaneous Nuclear Spectroscopy Telescope Array and Swift/XRT observations of the transient Be-neutron star binary KS 1947+300 taken during its outburst in 2013/2014. These broadband observations were supported by Swift/XRTmonitoring snapshots every three days, which we use to study the evolution of the spectrum over the outburst.We find strong changes of the power-law photon index, which shows a weak trend of softening with increasing X-ray flux. The neutron star shows very strong pulsations with a period of P [almost equal to] 18.8 s. The 0.8-79 keV broadband spectrum can be described by a power law with an exponential cutoff and a blackbody component at low energies. During the second observation we detect a cyclotron resonant scattering feature at 12.5 keV, which is absent in the phase-averaged spectra of observations 1 and 3. Pulse phase-resolved spectroscopy reveals that the strength of the feature changes strongly with pulse phase and is most prominent during the broad minimum of the pulse profile. At the same phases the line also becomes visible in the first and third observation at the same energy. This discovery implies that KS 1947+300 has a magnetic field strength of B [almost equal to] 1.1 1012(1 + z) G, which is at the lower end of known cyclotron line sources.
    Keywords: Astronomy
    Type: GSFC-E-DAA-TN16207 , GSFC-E-DAA-TN21840 , Astrophysical Journal Letters; 784; 2; L40
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  • 99
    Publication Date: 2019-07-13
    Description: The lunar surface is covered by a layer of fine, reactive dust. Very little is known regarding the toxicity of lunar dust on human physiology. This study assessed the toxicity of airborne lunar dust exposure in rats on pulmonary and systemic immune parameters.
    Keywords: Life Sciences (General)
    Type: JSC-CN-31994 , Annual Clinical Cytometry Meeting & Course; Oct 10, 2014 - Oct 14, 2014; Seattle, WA; United States
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  • 100
    Publication Date: 2019-07-13
    Description: No abstract available
    Keywords: Astronomy
    Type: M14-3805 , Asteroids, Comets, Meteors (ACM 2014); Jun 30, 2014 - Jul 04, 2014; Helsinki; Finland
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