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  • Molecular Diversity Preservation International  (223,279)
  • Oxford University Press  (72,378)
  • National Academy of Sciences  (30,232)
  • Annual Reviews
  • Springer Science + Business Media
  • 2020-2022  (244,823)
  • 2000-2004  (58,473)
  • 1980-1984  (29,496)
  • 1935-1939  (4,325)
Collection
Publisher
Years
Year
  • 1
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Philosophy, Introductions.
    Notes: Mind -- Knowledge -- Language -- Science -- Morality -- Politics -- Law -- Metaphysics -- Philosophy
    Pages: xviii, 412 p.
    ISBN: 0-19-518393-2
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  • 2
    Unknown
    New York : Oxford University Press
    Keywords: Anti-globalization movement. ; Globalization, Economic aspects. ; Globalization, Social aspects.
    Notes: I. Coping with anti-globalization -- 1. Anti-globalization: why? -- 2. Globalization: socially, not just economically, benign -- 3. Globalization is good but not good enough -- 4. Non-government organizations -- II. Globalization's human face: trade and corporations -- 5. Poverty: enhanced or diminished? -- 6. Child labor: increased or reduced? -- 7. Women: harmed or helped? -- 8. Democracy at bay? -- 9. Culture imperiled or enriched? -- 10. Wages and labor standards at stake? -- 11. Environment in peril? -- 12. Corporations: predatory or beneficial? -- III. Other dimensions of globalization -- 13. The perils of Gung-Ho International Financial capitalism -- 14. International flows of humanity -- IV. Appropriate governance: making globalization work better -- 15. Appropriate governance: an overview -- 16. Coping with downsides -- 17. Accelerating the achievement of social agendas -- 18. Managing transitions: optimal, not maximal, speed -- V. In conclusion -- 19. And so, let us begin anew
    Pages: xi, 308 p.
    ISBN: 0-19-530391-1
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  • 3
    Unknown
    Oxford ; New York : Oxford University Press
    Series in affective science  
    Keywords: Affect (Psychology) ; Electronic books ; Emotions
    Pages: xvii, 1199 p.
    ISBN: 0-19-530205-2
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  • 4
    Unknown
    New York : Oxford University Press
    Religion in America series  
    Keywords: Edwards, Jonathan,, 1703-1758.
    Pages: xii, 194 p.
    ISBN: 0-585-30895-0
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  • 5
    Unknown
    New York : Oxford University Press
    Keywords: Truth.
    Pages: ix, 268 p.
    ISBN: 0-585-32455-7
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  • 6
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Occom, Samson,, 1723-1792. ; African Americans in literature. ; African Americans, Intellectual life. ; American literature, African American authors, History and criticism. ; American literature, Indian authors, History and criticism. ; American literature, 1783-1850, History and criticism. ; American literature, Colonial period, ca. 1600-1775, History and criticism. ; American literature, Revolution, 1775-1783, History and criticism. ; Christian literature, American, History and criticism. ; Christianity and literature, United States, History, 18th century. ; Hymns, English, United States, History and criticism. ; Indians in literature. ; Indians of North America, Intellectual life.
    Pages: vi, 255 p.
    ISBN: 0-19-518567-6
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  • 7
    Unknown
    New York : Oxford University Press
    Keywords: United States, Social policy. ; Public welfare, United States, History.
    Pages: 210 p.
    ISBN: 0-585-35667-X
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  • 8
    Unknown
    Oxford ; New York : Oxford University Press
    Series in affective science  
    Keywords: Autobiographical memory. ; Brain, physiology. ; Emotions. ; Emotions, physiology. ; Memory, physiology. ; Mental Disorders, psychology. ; Psychiatry. ; Psychophysiology.
    Notes: Memory for emotional events / Daniel Reisberg and Friderike Heuer -- The neuroanatomy of emotional memory in humans / Tony W. Buchanan and Ralph Adolphs -- The biopsychology of trauma and memory / Jessica D. Payne ... [et al.] -- Forgetting trauma? / Richard J. McNally, Susan A. Clancy, and Heidi M. Barrett -- Selective memory effects in anxiety disorders : an overview of research findings and their implications / Colin MacLeod and Andrew Mathews -- Memory for emotional and nonemotional events in depression : a question of habit? / Paula Hertel -- Emotion, memory, and conscious awareness in schizophrenia / Jean-Marie Danion ... [et al.] -- Children's memories of emotional events / Robyn Fivush and Jessica McDermott Sales -- Aging and emotional memory / Mara Mather -- Emotion and eyewitness memory / Robin S. Edelstein ... [et al.] -- Emotional memory in survivors of the Holocaust : a qualitative study of oral testimony / Robert N. Kraft
    Pages: xiv, 413 p.
    ISBN: 0-19-518650-8
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  • 9
    Unknown
    New York : Oxford University Press
    Oxford paperback reference  
    Keywords: Christian saints, Biography, Dictionaries. ; Christian saints, Great Britain, Biography, Dictionaries. ; Christian saints, Ireland, Biography, Dictionaries. ; Saints chrétiens, Biographies, Dictionnaires anglais. ; Saints chrétiens, Grande-Bretagne, Biographies, Dictionnaires anglais. ; Saints chrétiens, Irlande, Biographies, Dictionnaires anglais.
    Pages: xxv, 547 p.
    Edition: 4th ed
    ISBN: 0-585-11034-4
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  • 10
    Unknown
    New York : Oxford University Press
    Religion in America series  
    Keywords: Evangelicalism, History. ; Religion and science, History.
    Notes: The history of science and religion : some evangelical dimensions / John Hedley Brooke -- The Puritan thesis revisited / John Morgan -- Christianity and early modern science : the Foster thesis reconsidered / Edward B. Davis -- Science, theology, and society : from Cotton Mather to William Jennings Bryan / Mark A. Noll -- Science and evangelical theology in Britain from Wesley to Orr / David W. Bebbington -- Science, natural theology, and evangelicalism in early nineteenth-century Scotland : Thomas Chalmers and the Evidence controversy / Jonathan R. Topham -- Scriptural geology in America / Rodney L. Stiling -- Situating evangelical responses to evolution / David N. Livingstone -- Telling tales : evangelicals and the Darwin legend / James Moore -- Creating creationism : meanings and uses since the age of Agassiz / Ronald L. Numbers -- A sign for an unbelieving age : evangelicals and the search for Noah's ark / Larry Eskridge -- "The science of duty" : moral philosophy and the epistemology of science in nineteenth-century America / Allen C. Guelzo -- Toward a Christian social science in Canada, 1890-1930 / Michael Gauvreau and Nancy Christie -- Evangelicals, Biblical scholarship, and the politics of the modern American academy / D.G. Hart -- The meaning of science for Christians : a new dialogue on Olympus / George Marsden
    Pages: vi, 351 p.
    ISBN: 0-585-18275-2
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  • 11
    Keywords: Europe, Intellectual life, 18th century. ; Europe, Intellectual life, 19th century. ; Europe, Vie intellectuelle, 18e siècle. ; Europe, Vie intellectuelle, 19e siècle. ; Enlightenment. ; Information resources, Europe, History, 18th century. ; Information resources, Europe, History, 19th century. ; Learning and scholarship, Europe, History, 18th century. ; Learning and scholarship, Europe, History, 19th century. ; Savoir et érudition, Europe, Histoire, 18e siècle. ; Savoir et érudition, Europe, Histoire, 19e siècle. ; Siècle des lumières. ; Sources d'information, Europe, Histoire, 18e siècle. ; Sources d'information, Europe, Histoire, 19e siècle.
    Pages: viii, 246 p.
    ISBN: 0-19-518040-2
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  • 12
    Unknown
    Oxford [England] ; New York : Oxford University Press
    American classical studies  
    Keywords: Greece, History, To 146 B.C. ; Grèce, Histoire, Jusqu'à 146 av. J.-C. ; Rome, Histoire. ; Rome, History. ; Civilisation ancienne. ; Civilization, Classical.
    Pages: xi, 151 p.
    ISBN: 0-19-518490-4
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  • 13
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Police, Europe, Histoire. ; Police, Europe, History. ; Police, Europe, History, 19th century. ; Police, France, Histoire. ; Police, France, History.
    Pages: x, 288 p.
    ISBN: 0-585-48633-6
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  • 14
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Angleterre, Mœurs et coutumes, 17e siècle. ; Angleterre, Mœurs et coutumes, 18e siècle. ; Angleterre, Mœurs et coutumes, 19e siècle. ; England, Social life and customs, 17th century. ; England, Social life and customs, 17th century. ; England, Social life and customs, 18th century. ; England, Social life and customs, 19th century. ; Anglais dans la littérature. ; Anglais, Histoire. ; English literature, History and criticism. ; Littérature anglaise, Histoire et critique. ; National characteristics, English, in literature. ; National characteristics, English, History.
    Notes: Energy -- Candour -- Decency -- Taciturnity -- Reserve -- Eccentricity -- Manners and character
    Pages: x, 389 p.
    ISBN: 0-585-48625-5
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  • 15
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Central America, Politics and government. ; Political violence, Central America, History. ; State-sponsored terrorism, Central America, History.
    Notes: Part 1 : 1821-1939. Historical dimensions of public violence in Latin America -- Binding hatreds : public violence, state, and nation in Central American history -- Guatemala : organizing for war -- El Salvador : a democracy of violence -- Honduras : caudillos in search of an army -- Nicaragua : a new army finds its caudillo -- Costa Rica : caudillos in search of a state -- Part 2 : 1940-1960. Transformations -- Defining collaboration : the United States and Central America -- Guatemala : "Showcase of Latin America" -- El Salvador : distrustful collaborator -- Honduras : remaking an "armed rabble" -- Nicaragua : "Ready to receive orders from Uncle Sam" -- Costa Rica : an army renamed -- Conclusions -- Statistical appendix -- Notes
    Pages: x, 336 p.
    ISBN: 0-19-518573-0
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  • 16
    Unknown
    New York : Oxford University Press
    Philosophy of mind series  
    Keywords: Consciousness. ; Dualism. ; Mind and body. ; Philosophy of mind.
    Pages: xvii, 414 p.
    ISBN: 0-585-35313-1
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  • 17
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Electronic books ; Vision disorders ; Visual perception
    Pages: ix, 135 p.
    ISBN: 1-423-70567-X
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  • 18
    Unknown
    New York : Oxford University Press
    Keywords: United States, History, Civil War, 1861-1865, Causes. ; United States, Race relations. ; United States, Social conditions, To 1865. ; Antislavery movements, United States, History, 19th century. ; Riots, United States, History, 19th century. ; Slavery, Government policy, United States. ; Violence, United States, History, 19th century.
    Pages: xx, 372 p.
    ISBN: 0-19-530397-0
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  • 19
    Unknown
    New York, N.Y : Oxford University Press
    Keywords: Dissenters, Religious, England, History, 19th century. ; Dissenters, Religious, England, History, 20th century. ; Dissidents (Religion), Angleterre, Histoire, 19e siècle. ; Dissidents (Religion), Angleterre, Histoire, 20e siècle. ; Theology, Study and teaching, England, History, 19th century. ; Theology, Study and teaching, England, History, 20th century. ; Théologie, Étude et enseignement, Angleterre, Histoire, 19e siècle. ; Théologie, Étude et enseignement, Angleterre, Histoire, 20e siècle.
    Pages: 248 p.
    ISBN: 0-585-16245-X
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  • 20
    Keywords: Great Britain, Civilization, 19th century. ; United States, Civilization, British influences. ; United States, Civilization, 20th century. ; Dickens, Charles,, 1812-1870, Appreciation, United States. ; Criticism, United States, History, 20th century. ; English literature, Appreciation, United States. ; English literature, 19th century, History and criticism, Theory, etc. ; Literature and science, Great Britain. ; Literature and science, United States. ; Postmodernism (Literature), United States. ; Romanticism, Great Britain.
    Pages: x, 270 p.
    ISBN: 0-19-518078-X
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  • 21
    Unknown
    New York : Oxford University Press
    Keywords: Bible., N.T., John. ; Bible., N.T., John, Commentaries.
    Pages: xiii, 625 p.
    Edition: Pbk. rpt. ed., 1997
    ISBN: 0-585-27829-6
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  • 22
    Unknown
    New York, N.Y : Oxford University Press
    Philosophy of mind series  
    Keywords: Ethics, Book reviews. ; Mind and body, Book reviews. ; Philosophy of mind, Book reviews.
    Pages: viii, 264 p.
    ISBN: 0-585-16169-0
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  • 23
    Unknown
    New York : Oxford University Press
    Keywords: Apologetics. ; Christianity, Philosophy. ; Faith and reason, Christianity.
    Pages: xx, 508 p.
    ISBN: 0-585-35267-4
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  • 24
    Keywords: Information society. ; Société informatisée.
    Pages: xxiii, 516 p.
    ISBN: 0-585-35755-2
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  • 25
    Unknown
    Oxford [England] ; New York, N.Y. [USA] : Oxford University Press
    Rutgers series on self and social identity  
    Keywords: Conflict management. ; Ethnic relations. ; Gestion des conflits. ; Group identity. ; Identité collective. ; Relations interethniques.
    Notes: Introduction : social identity and intergroup conflict / Lee Jussim, Richard D. Ashmore, and David Wilder / Ingroup identification and intergroup conflict : when does ingroup love become outgroup hate? / Marilynn B. Brewer -- Ethnic identity, national identity, and intergroup conflict : the significance of personal experiences / Thomas Hylland Eriksen -- The meaning of american national identity : patterns of ethnic conflict and consensus / Jack Citrin, Cara Wong, and Brian Duff -- Communal and national identity in a multiethnic state : a comparison of three perspectives / Jim Sidanius and John R. Petrocik -- Social and role identities and political violence : identity as a window on violence in northern ireland / Robert W. White -- Individual and group identities in genocide and mass killing / Ervin Staub -- The role of national identity in conflict resolution : experiences from Israeli-Palestinian problem-solving workshops / Herbert C. Kelman -- Conclusion : toward a social identity framework for intergroup conflict / Richard D. Ashmore, Lee Jussim, David Wilder, and Jessica Heppen
    Pages: xii, 270 p.
    ISBN: 0-19-530241-9
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  • 26
    Unknown
    New York : Oxford University Press
    Keywords: Ethnopsychology. ; Personality and culture.
    Notes: Culture and psychology at a crossroad : historical perspective and theoretical analysis / John Adamopoulos and Walter J. Lonner -- Individualism and collectivism : past, present, and future / Harry C. Tirandis -- Culture, science, and indigenous psychologies : an integrated analysis / Uichol Kim -- The evolution of cross-cultural research methods / Fons van de Vijver -- Culture, context, and development / Harry W. Gardiner -- Cognition across cultures / R.C. Mishra -- Everyday cognition : where culture, psychology, and education come together / Analúcia D. Schliemann and David W. Carraher -- Culture and moral development / Joan G. Miller -- Culture and emotion / David Matsumoto -- Gender and culture / Deborah L. Best and John E. Williams -- Culture and control orientations / Susumu Yamaguchi -- Culture and human inference : perspectives from three traditions / Kaiping Peng, Daniel R. Ames, and Eric D. Knowles -- Abnormal psychology and culture / Junko Tanaka-Matsumi -- Clinical psychology and culture / Jayne Lee and Stanley Sue -- Polishing the jade : a modest proposal for improving the study of social psychology across cultures / Michael Harris Bond and James T. Tedeschi -- Culture and social cognition : toward a social psychology of cultural dynamics / Yoshihisa Kashima -- Cross-cultural studies of social influence / Peter B. Smith -- Social justice from a cultural perspective / Kwok Leung and Walter G. Stephan -- The A, B, Cs of acculturation / Colleen Ward
    Pages: xvi, 458 p.
    ISBN: 0-19-530227-3
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  • 27
    Unknown
    Oxford ; New York : Oxford University Press
    Series in affective science  
    Keywords: Emotions (Philosophy)
    Notes: Emotions, physiology, and intentionality.Primitive emotions /John Deigh --Emotion : biological fact or social construction /Jenefer Robinson --Embodied emotions /Jesse Prinz --Emotion, appraisal, and cognition.Emotions : what I know, what I'd like to think I know, and what I'd like to think /Ronald de Sousa --Emotions, thoughts, and feelings : emotions as engagements with the world /Robert C. Solomon --Emotions and feelings.Emotion, feeling, and knowledge of the world /Peter Goldie --Subjectivity and emotion /Cheshire Calhoun --Emotions and rationality.Emotions, rationality, and mind/body /Patricia Greenspan --Some considerations about intellectual desire and emotions /Michael Stocker --Emotions, action, and freedom.Emotion and action /Jon Elster --Emotions and freedom /Jerome Neu --Emotion and value.Emotions as judgments of value and importance /Martha Nussbaum --Feelings that matter /Annette Baier --Perturbations of desire : emotions disarming morality in the "Great song" of The Mahabharata /Purushottama Bilimoria --On theories of emotion.Is emotion a natural kind? /Paul E. Griffiths --Emotion as a subtle mental mode /Aaron Ben-Zeev --Enough already with "Theories of emotions" /Amelie Oksenberg Rorty.
    Pages: x, 297 p.
    ISBN: 0-19-530334-2
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  • 28
    Unknown
    Oxford ; New York : Oxford University Press
    Oxford series in cognitive development  
    Keywords: Cognition in infants. ; Cognition, physiology, Infant. ; Concepts in infants. ; Thinking, physiology, Infant.
    Notes: How to build a baby : prologue -- Piaget's sensorimotor infant -- Kinds of representation : seeing and thinking -- Perceptual meaning analysis and image-schemas : the infant as interpreter -- Some image-schemas and their functions -- Some differences between percepts and concepts : the case of the basic level -- Some preverbal concepts -- Conceptual categories as induction machines -- Continuity in the conceptual system : acquisition, breakdown, and reorganization -- Recall of the past -- Language acquisition -- Consciousness and conclusions
    Pages: xiii, 359 p.
    ISBN: 0-19-530396-2
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  • 29
    Unknown
    New York : Oxford University Press
    Keywords: Color (Philosophy)
    Pages: xv, 228 p.
    ISBN: 0-585-36474-5
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  • 30
    Keywords: Denver (Colo.), History, 20th century. ; Middlebury (Vt. : Town), History, 20th century. ; Smyrna (Rutherford County, Tenn.), History, 20th century. ; Cities and towns, United States, Growth, History, 20th century, Case studies. ; Interstate Highway System, History, 20th century. ; Roads, Government policy, United States, History, 20th century. ; Transportation, Automotive, United States, History, 20th century.
    Notes: Highway federalism -- Denver meets the automobile -- The decentralization of post-World War II Denver -- Automobiles and a small town -- Bridges, bypasses, and boulevards -- AutoCity : Smyrna, Tennessee
    Pages: xiv, 297 p.
    ISBN: 0-19-530264-8
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  • 31
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: United States, History, 1783-1815. ; United States, History, Colonial period, ca. 1600-1775. ; United States, History, Revolution, 1775-1783.
    Notes: Preface -- 1754-1763 : Join, or die -- 1763-1766 : Loss of respect and affection -- 1766-1770 : To crush the spirit of the colonies -- 1770-1774 : Cause of Boston now is the cause of America -- 1775-1776 : To die freemen rather than to live slaves -- 1776-1777 : Leap into the dark -- 1778-1782 : This wilderness of darkness and dangers -- 1783-1787 : Present paroxysm of our affairs -- 1787-1789 : So much unanimity and good will -- 1790-1793 : Prosperous at home, respectable abroad -- 1793-1796 : Colossus to the Antirepublican party -- 1797-1799 : Game where principles are the stake -- 1799-1801 : Gigg is up -- 1801 : Age of revolution and reformation
    Pages: xv, 558 p.
    ISBN: 0-19-518418-1
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  • 32
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Amish Country (Pa.) ; Lancaster County (Pa.), Rural conditions. ; Rural development, Pennsylvania, Lancaster County.
    Notes: Introduction: a fertile soil -- Cultivating the garden : the invention of Lancaster County -- Pride and progress : education, literacy, and the little red schoolhouse -- Dutch country : the Amish and tourism -- Domain of abundance : food and farming -- Landscape of progress : urbanization and planning -- Preserving the garden : development and farm preservation -- Epilogue: the harvest -- Appendix : Farms and population of Lancaster County, 1900-2000
    Pages: x, 258 p.
    ISBN: 0-19-518029-1
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  • 33
    Keywords: Consolidation and merger of corporations. ; Human capital. ; Organizational effectiveness.
    Pages: xi, 193 p.
    ISBN: 0-19-518406-8
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  • 34
    Unknown
    New York : Oxford University Press
    Keywords: Philosophy and science. ; Thought experiments.
    Pages: xii, 318 p.
    Edition: [Pbk. reprint 1998]
    ISBN: 0-585-16074-0
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  • 35
    Unknown
    Oxford ; New York : Oxford University Press
    Very short introductions  
    Keywords: Postmodernism.
    Pages: 142 p.
    ISBN: 0-585-48631-X
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  • 36
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Industrial relations. ; Organizational behavior. ; Organizational sociology.
    Pages: x, 294 p.
    ISBN: 0-585-36603-9
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  • 37
    Unknown
    New York : Oxford University Press
    Keywords: Holocaust, Jewish (1939-1945), Influence. ; Holocaust, Jewish (1939-1945), Psychological aspects. ; Holocaust, Jewish (1939-1945), Social aspects. ; Social sciences, Philosophy.
    Notes: The psychology of bystanders, perpetrators, and heroic helpers / Ervin Staub -- What is a "social-psychological" account of perpetrator behavior? The person versus the situation in Goldhagen's Hitler's willing executioners / Leonard S. Newman -- Authoritarianism and the Holocaust: some cognitive and affective implications / Peter Suedfeld and Mark Schaller -- Perpetrator behavior as destructive obedience: an evaluation of Stanley Milgram's perspective, the most influential social-psychological approach to the Holocaust / Thomas Blass -- Sacrificial lambs dressed in wolves' clothing: envious prejudice, ideology, and the scapegoating of Jews / Peter Glick -- Group processes and the Holocaust / R. Scott Tindale ... [et al.] -- Examining the implications of cultural frames on social movements and group action / Daphna Oyserman and Armand Lauffer -- Population and predators: preconditions for the Holocaust from a control-theoretical perspective / Dieter Frey and Helmut Rez -- The zoomorphism of human collective violence / R.B. Zajonc -- The Holocaust and the four roots of evil / Roy F. Baumeister -- Instigators of genocide: examining Hitler from a social-psychological perspective / David R. Mandel -- Perpetrators with a clear conscience: lying self-deception and belief change / Ralph Erber -- Explaining the Holocaust: does social psychology exonerate the perpetrators? / Arthur G. Miller, Amy M. Buddie, and Jeffrey Kretschmar -- Epilogue: Social psychologists confront the Holocaust / Leonard S. Newman and Ralph Erber
    Pages: xi, 360 p.
    ISBN: 0-19-518618-4
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  • 38
    Unknown
    Oxford [England] ; New York : Oxford University Press
    Keywords: United States, Civilization, Philosophy. ; United States, Politics and government, Philosophy. ; National characteristics, American. ; Social values, United States.
    Notes: Introduction: A dream country -- Dream of the good life (I) : the Puritan enterprise -- Dream charter : The declaration of independence -- Dream of the good life (II) : upward mobility -- King of America : the dream of equality -- Detached houses : the dream of home ownership -- Dream of the good life (III) : the coast -- Conclusion: Extending the dream
    Pages: x, 214 p.
    ISBN: 0-19-530398-9
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  • 39
    Unknown
    New York : Oxford University Press
    Oxford readings in feminism  
    Keywords: Feminist theory. ; Women, History.
    Notes: Does a sex have a history? /Denise Riley --The dialects of Black womanhood /Bonnie Thornton Dill --Theorizing woman:Funu, Guojia, Jiating (Chinese women, Chinese state, Chinese family) /Tani Barlow --'Women's history' in transition: the European case /Natalie Zemon Davis --The traffic in women: notes on the 'political economy' of sex /Gayle Rubin --Gender: a useful category of historical analysis /Joan Wallach Scott --African-American women's history and the metalanguge of race /Evelyn Brooks Higginbotham --Carnal knowledge.
    Pages: ix, 611 p.
    ISBN: 0-585-15703-0
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  • 40
    Unknown
    New York : Oxford University Press
    Keywords: United States, Church history, Congresses. ; Christianity, United States, Congresses.
    Pages: ix, 502 p.
    ISBN: 0-585-30487-4
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  • 41
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: United States, Foreign relations, Philosophy. ; United States, Foreign relations, 2001- ; Globalization, Political aspects. ; National characteristics, American.
    Pages: xiv, 288 p.
    Edition: [Pbk. ed.]
    ISBN: 0-19-518433-5
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  • 42
    Unknown
    Oxford : Oxford University Press
    Oxford readings in feminism  
    Keywords: Feminist theory. ; Science, Philosophy. ; Science, Social aspects. ; Women in science.
    Pages: vii, 289 p.
    ISBN: 0-585-12065-X
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  • 43
    Keywords: English literature, 18th century. ; Erotic literature, English. ; Libertinism, Literary collections.
    Notes: British libertine literature before Fanny Hill (1749) -- 1: The school of Venus (1680) -- 2: The pleasure of a single life (1701), The fifteen comforts of Cuckoldom (1706), and the fifteen plagues of a maiden-head (1707) -- 3: Gonosologium Novum (1709) -- 4: Venus in the cloister (1725) -- 5: A dialogue between a married lady and a maid (1740) -- 6: A new description of merryland (1741) -- 7: The female husband (1746)
    Pages: xxxiii, 332 p.
    ISBN: 0-19-518577-3
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  • 44
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Capital social (Sociologie) ; Civil society. ; Democracy. ; Démocratie. ; Social capital (Sociology) ; Société civile.
    Notes: Introduction /Robert D. Putnam and Kristin A. Goss --Great Britain: the role of government and the distribution of social capital /Peter A. Hall --United States: bridging the privileged and the marginalized? /Robert Wuthnow --United States: from membership to advocacy /Theda Skocpol --France: old and new civic and social ties in France /Jean-Pierre Worms --Decline of social capital?: the German case /Claus Offe and Susanne Fuchs --From civil war to civil society: social capital in Spain from the 1930s to the 1990s /Victor Pérez-Díaz --Sweden: social capital in the social democratic state /Bo Rothstein --Australia: making the lucky country /Eva Cox --Broadening the basis of social capital in Japan /Takashi Inoguchi --Conclusion /Robert D. Putnam.
    Pages: 516 p.
    ISBN: 0-19-518460-2
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  • 45
    Unknown
    Oxford : Oxford University Press
    Keywords: Philosophie, Encyclopédies. ; Philosophy, Encyclopedias.
    Pages: xviii, 1009 p.
    ISBN: 0-585-18263-9
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  • 46
    Unknown
    New York, N.Y : Oxford University Press
    Keywords: Arab-Israeli conflict, Religious aspects. ; Arab-Israeli conflict, 1993-, Peace. ; Religion and politics, Middle East.
    Pages: viii, 269 p.
    ISBN: 0-19-518512-9
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  • 47
    Keywords: France, Race relations, History, 18th century. ; Blacks, Legal status, laws, etc., France, History, 18th century. ; Political culture, France, History, 18th century. ; Racism, France, History, 18th century.
    Pages: x, 210 p.
    ISBN: 0-585-32788-2
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  • 48
    Unknown
    New York : Oxford University Press
    Keywords: Etiquette, United States, History.
    Notes: Part I -- Hierarchy: manners in a vertical social order, 1620-1740.Manners for gentlemenManners over minorsManners maketh menPart II --Revolution: an opening of possibilities, 1740-1820.Middle class risingYouth risingWomen risingPart III -- Resolution: manners for democrats, 1820-1860.Manners for the middle classManners for adultsLadies first?
    Pages: x, 310 p.
    ISBN: 0-19-530339-3
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  • 49
    Unknown
    New York : Oxford University Press
    Keywords: Judaism, Dictionaries.
    Pages: xviii, 764 p.
    ISBN: 0-585-38345-6
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  • 50
    Unknown
    Oxford ; New York : Oxford University Press
    Studies in the history of sexuality  
    Keywords: Venice (Italy), Social conditions, To 1797 ; Electronic books ; Marriage, History, Italy, Venice ; Renaissance, Italy, Venice
    Pages: xi, 221 p.
    ISBN: 0-19-518018-6
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  • 51
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Great Britain, Relations, Ireland. ; Ireland, In literature. ; Ireland, Relations, Great Britain. ; Joyce, James,, 1882-1941., Ulysses. ; Joyce, James,, 1882-1941, Aesthetics. ; Joyce, James,, 1882-1941, Political and social views. ; Literature and history, Ireland, History, 20th century. ; Politics and literature, Ireland, History, 20th century.
    Pages: xii, 306 p.
    ISBN: 0-585-48623-9
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  • 52
    Unknown
    New York : Oxford University Press
    Oxford paperback reference  
    Keywords: Philosophie, Dictionnaires anglais. ; Philosophy, Dictionaries.
    Pages: ix, 418 p.
    ISBN: 0-585-11072-7
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  • 53
    Unknown
    New York : Oxford University Press
    Keywords: Wesley, Susanna Annesley,, 1669-1742. ; Wesley, Susanna Annesley,, 1670-1742. ; Anglicans, England, Biography.
    Pages: xiv, 504 p.
    ISBN: 0-585-24572-X
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  • 54
    Unknown
    New York : Oxford University Press
    Keywords: Crime in literature. ; Criminal liability in literature. ; Criminals in literature. ; English fiction, 19th century, History and criticism. ; Law and literature, History, 19th century. ; Legal stories, English, History and criticism. ; Responsibility in literature.
    Notes: Organizing crime : conduct and character in Oliver Twist : prologue to George Eliot's crimes -- "To fix our minds on that consequence" : minding consequences in Adam Bede and Felix Holt -- Middlemarch, Daniel Deronda, and the crime in mind -- James Fitzjames Stephen and the responsibilities of narrative -- Modern responsibilities
    Pages: viii, 275 p.
    ISBN: 0-19-518524-2
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  • 55
    Unknown
    Oxford : Oxford University Press
    Keywords: Ireland, Defenses, History, 20th century. ; Ireland, Foreign relations, 1922- ; Ireland, Military policy, History, 20th century. ; Ireland, Politics and government, 1922- ; National security, Ireland, History, 20th century.
    Pages: 382 p.
    ISBN: 0-585-48615-8
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  • 56
    Unknown
    New York : Oxford University Press
    Keywords: United States, Ethnic relations, History, 19th century. ; United States, Race relations, History, 19th century. ; American fiction, 19th century, History and criticism. ; Caricatures and cartoons, United States, History, 19th century. ; Ethnicity in literature. ; Race in literature. ; Realism in literature. ; Stereotype (Psychology) in literature.
    Notes: Introduction: the age of caricature, the age of realism -- William Dean Howells and the touch of exaggeration which typifies -- "I want a real coon": Twain and ethnic caricature -- A Jamesian art to be cultivated -- Edith Wharton's flamboyant copy -- The "curious realism" of Charles Chesnutt
    Pages: viii, 196 p.
    ISBN: 0-19-518578-1
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  • 57
    Unknown
    New York : Oxford University Press
    Keywords: Eliot, T. S., (Thomas Stearns),, 1888-1965, Views on war. ; Pound, Ezra,, 1885-1972, Views on war. ; Woolf, Virginia,, 1882-1941, Views on war. ; American poetry, 20th century, History and criticism. ; Americans, Great Britain, History, 20th century. ; Modernism (Literature), Great Britain. ; Modernism (Literature), United States. ; World War, 1914-1918, Great Britain, Literature and the war.
    Pages: xiii, 395 p.
    ISBN: 0-19-518055-0
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  • 58
    Unknown
    Oxford : Oxford University Press
    Keywords: Consciousness. ; Neuropsychology.
    Pages: 272 p.
    ISBN: 0-585-24486-3
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  • 59
    Unknown
    Oxford ; New York : Oxford University Press
    Keywords: Mouvements sociaux. ; Social movements.
    Notes: pt. I. Introduction. Opportunities and identities: bridge-building in the study of social movements / David S. Meyer -- pt. II. States and policies. State repression and democracy protest in three southeast Asian countries / Vincent Boudreau -- Mobilization on the South African gold mines / T. Dunbar Moodie -- Multiple meditations: the state and the women's movements in India / Manisha Desai -- The contradictions of gay ethnicity: forging identity in Vermont / Mary Bernstein -- Creating social change: lessons from the civil rights movement / Kenneth T. Andrews -- pt. III. Organization and strategies. The "meso" in social movement research / Suzanne Staggenborg -- Strategizing and the sense of context: reflections on the first two weeks of the Liverpool docks lockout, September-October 1995 / Colin Barker and Michael Lavalette -- Factions and the continuity of political challengers / Mildred A. Schwartz -- More than one feminism: organizational structure and the construction of collective identity / Jo Reger -- The development of individual identity and consciousness among movements of the left and right / Rebecca E. Klatch -- pt. IV. Collective identities, discourse, and culture. Toward a more dialogic analysis of social movement culture / Marc W. Steinberg -- Materialist feminist discourse analysis and social movement research: mapping the changing context for "community control" / Nancy A. Naples -- From the "beloved community" to "family values": religious language, symbolic repertoires, and democratic culture / Rhys H. Williams -- External political change, collective identities, and participation in social movement organizations / Belinda Robnett -- pt. V. Conclusion. Meaning and structure in social movements / Nancy Whittier
    Pages: xvi, 366 p.
    ISBN: 0-19-530277-X
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  • 60
    Publication Date: 2021-03-15
    Description: In a recent work we computed the relative frequencies with which strong shocks (4.0≤Mw〈5.0), widely felt by the population were followed in the same area by potentially destructive main shocks (Mw≥5.0) in Italy. Assuming the stationarity of the seismic release properties, such frequencies can be tentatively used to estimate the probabilities of potentially destructive shocks after the occurrence of future strong shocks. This allows us to set up an alarm-based forecasting hypothesis related to strong foreshocks occurrence. Such hypothesis is tested retrospectively on the data of a homogenized seismic catalogue of the Italian area against a purely random hypothesis that simply forecasts the target main shocks proportionally to the space-time fraction occupied by the alarms. We compute the latter fraction in two ways a) as the ratio between the average time covered by the alarms in each area and the total duration of the forecasting experiment (60 years) and b) as the same ratio but weighted by the past frequency of occurrence of earthquakes in each area. In both cases the overall retrospective performance of our forecasting algorithm is definitely better than the random case. Considering an alarm duration of three months, the algorithm retrospectively forecasts more than 70% of all shocks with Mw5.5 occurred in Italy from 1960 to 2019 with a total space-time fraction covered by the alarms of the order of 2%. Considering the same space-time coverage, the algorithm is also able to retrospectively forecasts more than 40% of the first main shocks with Mw5.5 of the seismic sequences occurred in the same time interval. Given the good reliability of our results, the forecasting algorithm is set and ready to be tested also prospectively, in parallel to other ongoing procedures operating on the Italian territory.
    Description: This paper benefitted from funding provided by the European Union within the ambit of the H2020 project RISE (No. 821115), which in particular fully financed the PhD grant of one of the authors (E.B.).
    Description: Published
    Description: 1192–1206
    Description: 6T. Studi di pericolosità sismica e da maremoto
    Description: JCR Journal
    Keywords: Earthquake interaction ; Statistical seismology ; forecasting, ; prediction ; 04.06. Seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 61
    Publication Date: 2020-10-16
    Description: This article has been accepted for publication in Geophysical Journal International ©: The Authors 2019. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved. Uploaded in accordance with the publisher's self-archiving policy.
    Description: The active tectonic processes in convergent margins confer a high degree of complexity to the crust. Determining the thermal structure is, therefore, key to better elucidate the nature of those processes. In order to reconstruct the thermal structure of the crust beneath the Italian peninsula, we combine the most recent and accurate shear-wave velocity model that is currently available with thermodynamic modelling, assuming a global average crustal composition with no lateral variations. Our model, presented in terms of Moho temperature and crustal thermal gradients, shows a very good agreement with the known thermal anomalies associated with the backarc spreading related to the Apennine subduction. Importantly, we envisage a new anomalous region of high Moho temperatures in NW Italy (T 〉 800 degrees C at 30 km), at the transition between the Alps and Apennine orogens. The lowest temperatures of our model, corresponding to geothermal gradients 〈 19 degrees C km(-1), are obtained in the still active but slow-convergent portion of the northern Apennine. Moho temperatures increase moving southwards along the Apennine chain, an observation that is coherent with the evidence of ceasing subduction and consequent rebalancing of the depressed isotherms along the slab. Our results suggest that a thermal structure in different tectonic settings can be inferred with acceptable uncertainties based on absolute seismic velocity models. In this sense, our approach can be extended to any other region.
    Description: Published
    Description: 239–247
    Description: 1T. Struttura della Terra
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 62
    Publication Date: 2020-12-15
    Description: This article has been accepted for publication in Geophysical Journal International ©: The Authors 2015. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved. Uploaded in accordance with the publisher's self-archiving policy.
    Description: ectonic earthquake swarms challenge our understanding of earthquake processes since it is difficult to link observations to the underlying physical mechanisms and to assess the hazard they pose. Transient forcing is thought to initiate and drive the spatio-temporal release of energy during swarms. The nature of the transient forcing may vary across sequences and range from aseismic creeping or transient slip to diffusion of pore pressure pulses to fluid redistribution and migration within the seismogenic crust. Distinguishing between such forcing mechanisms may be critical to reduce epistemic uncertainties in the assessment of hazard due to seismic swarms, because it can provide information on the frequency–magnitude distribution of the earthquakes (often deviating from the assumed Gutenberg–Richter relation) and on the expected source parameters influencing the ground motion (for example the stress drop). Here we study the ongoing Pollino range (Southern Italy) seismic swarm, a long-lasting seismic sequence with more than five thousand events recorded and located since October 2010. The two largest shocks (magnitude M w = 4.2 and M w = 5.1) are among the largest earthquakes ever recorded in an area which represents a seismic gap in the Italian historical earthquake catalogue. We investigate the geometrical, mechanical and statistical characteristics of the largest earthquakes and of the entire swarm. We calculate the focal mechanisms of the M l 〉 3 events in the sequence and the transfer of Coulomb stress on nearby known faults and analyse the statistics of the earthquake catalogue. We find that only 25 per cent of the earthquakes in the sequence can be explained as aftershocks, and the remaining 75 per cent may be attributed to a transient forcing. The b-values change in time throughout the sequence, with low b-values correlated with the period of highest rate of activity and with the occurrence of the largest shock. In the light of recent studies on the palaeoseismic and historical activity in the Pollino area, we identify two scenarios consistent with the observations and our analysis: This and past seismic swarms may have been ‘passive’ features, with small fault patches failing on largely locked faults, or may have been accompanied by an ‘active’, largely aseismic, release of a large portion of the accumulated tectonic strain. Those scenarios have very different implications for the seismic hazard of the area.
    Description: Published
    Description: 1553–1567
    Description: 4T. Sismicità dell'Italia
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 63
    Publication Date: 2021-01-18
    Description: The horizontal to vertical spectral ratio (HVSR) of seismic noise is often used to investigate site effects, and it is usually assumed to be a stable feature of the site considered. Here we show that such an assumption is not always justified, and may lead to incorrect conclusions. The HVSR analysis was performed on ambient seismic noise recordings lasting from weeks to months at many sites in Calabria, Italy. Results show a variety of site effects, from the resonance of a shallow sedimentary layer to the polarized amplification of horizontal ground motion associated with topographic effects. We describe the results of seven sites whose HVSR is characterized by dual content: one that is persistent, and another appearing only occasionally. Two sites very near the coast of the Tyrrhenian sea and five sites in the Calabrian Arc mountains show the most remarkable results. The shape of the HVSR changes significantly at these sites when the amplitude of background noise increases in a broad frequency band during periods of bad weather. The occasional contribution to the HVSR consists of one or more peaks, depending on the site, that appear only when the amplitude of ambient noise is higher than usual. The seven sites where we observe the HVSR variability are all located in complex geological environments, on mountains, ridges or foothills. A variation of the HVSR correlated with the day–night cycle is also observed at some of these sites.
    Description: Published
    Description: 2162–2171
    Description: 1T. Struttura della Terra
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 64
    Publication Date: 2021-02-10
    Description: The 2007 caldera-forming eruption of Piton de la Fournaise (PdF) erupted the largest volume of magma (210 Mm3)recorded at this volcano in at least three centuries. Major and trace element and Sr^Nd isotope data for bulk-rocks, groundmasses and olivine phenocrysts have been combined with melt inclusion data (major, trace and volatile elements) to track magma evolution over the whole eruptive sequence. We show that each eruptive phase had a distinctive geochemical and petrological signature and that caldera collapse on 5 April was preceded by a marked shift in bulk magma composition and crystal content and size. Aphyric basalt erupted at the beginning of the sequence (February 2007) had relatively high Sr isotope ratio (87Sr/86Sr ¼ 0·70420^0·704180) and low Nd isotopic ratio(143Nd/144Nd ¼ 0·51285^0·51286). Olivine-basalts extruded on2^5 April just before caldera collapse are less enriched in radiogenic Sr (87Sr/86Sr ¼ 0·70412^0·70416), but characterized by the same Nd isotopic composition. This magma is interpreted as a new deep input, which pressurized the shallow PdF plumbing system and triggered the 2007 activity. Post-collapse oceanite lavas represent the main volume of magma extruded in 2007. Their bulk-rocks and groundmasses have 87Sr/86Sr (0·70418) intermediate between those of February and 5 April, and similar to those of the March 2007 and 2001^2006 lavas.We show that the Steady State Basalts (SSB) commonly erupted at PdF are hybrid melts, which result from multistep mixing between ‘alkaline’and ‘transitional’end-members. Our results lead us to propose a new model of the PdF plumbing system to reconcile the petrological, geochemical and geophysical observations: (1) the shallow portion (above sea level) of the PdF plumbing system hosts several small sills, in which magma experiences variable degrees of degassing, cooling and crystallization; (2) oceanite lavas result from the withdrawal of shallow harrisitic mushes stored at low pressures (548 MPa; 51800^2400 m depth) below both the volcano summit and its eastern flank; (3) water degassing plays a major role in fast magma crystallization at shallow depths. Multistep ascent and periodic extrusion of the shallow magmas is promoted by injections of deeper and hotter basaltic magma, containing up to 1·3 wt % H2O and 1630 ppm S. In 2007, the new deep input was the ultimate source of the large excess in sulfur degassing detected by satellites. Lateral draining and intrusion of magma below the eastern flank of the volcano are the cause of major volcano deformation, flank sliding and summit caldera collapse.
    Description: Published
    Description: 1287-1315
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: 3V. Proprietà chimico-fisiche dei magmi e dei prodotti vulcanici
    Description: 4V. Processi pre-eruttivi
    Description: 6A. Geochimica per l'ambiente e geologia medica
    Description: JCR Journal
    Keywords: Piton de la Fournaise ; plumbing system ; magma reservoir ; caldera collapse ; melt inclusions ; volatile budget ; isotope geochemistry ; basalt
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 65
    Publication Date: 2021-02-23
    Description: The preparation, initiation, and occurrence dynamics of earthquakes in Italy are governed by several frequently unknown physical mechanisms and parameters. Understanding these mechanisms is crucial for developing new techniques and approaches for earthquake monitoring and hazard assessments. Here, we develop a first-order numerical model simulating quasi-static crustal interseismic loading, coseismic brittle episodic dislocations, and postseismic relaxation for extensional and compressional earthquakes in Italy based on a common framework of lithostatic and tectonic forces. Our model includes an upper crust, where the fault is locked, and a deep crust, where the fault experiences steady shear.
    Description: Published
    Description: 627–645
    Description: 2T. Deformazione crostale attiva
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 66
    Publication Date: 2021-03-24
    Description: The 2016–17 central Italy earthquake sequence began with the first mainshock near the town of Amatrice on August 24 (MW 6.0), and was followed by two subsequent large events near Visso on October 26 (MW 5.9) and Norcia on October 30 (MW 6.5), plus a cluster of 4 events with MW 〉 5.0 within few hours on January 18, 2017. The affected area had been monitored before the sequence started by the permanent Italian National Seismic Network (RSNC), and was enhanced during the sequence by temporary stations deployed by the National Institute of Geophysics and Volcanology and the British Geological Survey. By the middle of September, there was a dense network of 155 stations, with a mean separation in the epicentral area of 6–10 km, comparable to the most likely earthquake depth range in the region. This network configuration was kept stable for an entire year, producing 2.5 TB of continuous waveform recordings. Here we describe how this data was used to develop a large and comprehensive earthquake catalogue using the Complete Automatic Seismic Processor (CASP) procedure. This procedure detected more than 450,000 events in the year following the first mainshock, and determined their phase arrival times through an advanced picker engine (RSNI-Picker2), producing a set of about 7 million P- and 10 million S-wave arrival times. These were then used to locate the events using a non-linear location (NLL) algorithm, a 1D velocity model calibrated for the area, and station corrections and then to compute their local magnitudes (ML). The procedure was validated by comparison of the derived data for phase picks and earthquake parameters with a handpicked reference catalogue (hereinafter referred to as ‘RefCat’). The automated procedure takes less than 12 hours on an Intel Core-i7 workstation to analyse the primary waveform data and to detect and locate 3000 events on the most seismically active day of the sequence. This proves the concept that the CASP algorithm can provide effectively real-time data for input into daily operational earthquake forecasts, The results show that there have been significant improvements compared to RefCat obtained in the same period using manual phase picks. The number of detected and located events is higher (from 84,401 to 450,000), the magnitude of completeness is lower (from ML 1.4 to 0.6), and also the number of phase picks is greater with an average number of 72 picked arrival for a ML = 1.4 compared with 30 phases for RefCat using manual phase picking. These propagate into formal uncertainties of ± 0.9km in epicentral location and ± 1.5km in depth for the enhanced catalogue for the vast majority of the events. Together, these provide a significant improvement in the resolution of fine structures such as local planar structures and clusters, in particular the identification of shallow events occurring in parts of the crust previously thought to be inactive. The lower completeness magnitude provides a rich data set for development and testing of analysis techniques of seismic sequences evolution, including real-time, operational monitoring of b-value, time-dependent hazard evaluation and aftershock forecasting.
    Description: Published
    Description: 555–571
    Description: 3T. Fisica dei terremoti e Sorgente Sismica
    Description: JCR Journal
    Keywords: 04.06. Seismology
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  • 67
    Publication Date: 2021-05-12
    Description: erratum paper
    Description: Published
    Description: 1090-1092
    Description: 1T. Struttura della Terra
    Description: JCR Journal
    Keywords: Theoretical seismology ; Seismic attenuation ; Seismic noise ; Surface waves ; Free oscillations ; Seismic interferometry ; 04.06. Seismology ; 04.01. Earth Interior
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 68
    Publication Date: 2021-05-12
    Description: This article has been accepted for publication inGeophysical Journal International ©The Author(s) 2020. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.
    Description: Determining the crustal structure of ocean island volcanoes is important to understand the formation and tectonic evolution of the oceanic lithosphere and tectonic swells in marine settings, and to assess seismic hazard in the islands. The Azores Archipelago is located near a triple junction system and is possibly under the influence of a mantle plume, being at the locus of a wide range of geodynamic processes. However, its crustal structure is still poorly constrained and debated due to the limited seismic coverage of the region and the peculiar linear geometry of the islands. To address these limitations, in this study we invert teleseismic Rayleigh wave ellipticity measurements for 1-D shear wave speed (VS) crustal models of the Azores Archipelago. Moreover, we test the reliability of these new models by using them in independent moment tensor inversions of local seismic data and demonstrate that our models improve the waveform fit compared to previous models. We find that data from the westernmost seismic stations used in this study require a shallower Moho depth (∼10 km) than data from stations in the eastern part of the archipelago (∼13–16 km). This apparent increase in the Moho depth with increasing distance from the mid-Atlantic ridge (MAR) is expected. However, the rate at which Moho deepens away from the MAR is greater than that predicted from a half-space cooling model, suggesting that local tectonic perturbations have modified crustal structure. The 1-D VS models obtained beneath the westernmost seismic stations also show higher wave speeds than for the easternmost stations, which correlates well with the ages of the islands except Santa Maria Island. We interpret the relatively low VS profile found beneath Santa Maria Island as resulting from underplating, which agrees with previous geological studies of the island. Compared to a recent receiver function study of the region, the shallow structure (top ∼2 km) in our models shows lower shear wave speed, which may have important implications for future hazard studies of the region. More generally, the new seismic crustal models we present in this study will be useful to better understand the tectonics, seismicity, moment tensors and strong ground motions in the region.
    Description: Published
    Description: 1232–1247
    Description: 5T. Sismologia, geofisica e geologia per l'ingegneria sismica
    Description: JCR Journal
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  • 69
    Publication Date: 2021-05-12
    Description: The island of Pantelleria, located in the Sicily Channel Rift Zone (Italy), has been the site of violent peralkaline silicic magmatism alternating with minor effusive to low-intensity Strombolian erup- tions of basaltic composition. The basaltic rock suites exposed on the island were sampled to in- vestigate the plumbing system dynamics through the study of chemical stratigraphy and temporal records of olivine crystals. Our petrographic and geochemical observations, together with the com- positional variability of olivine, suggest different evolutionary histories for basaltic magmas erupted over two major periods divided by the 􏰃45 ka Green Tuff (GT) eruption. Core-to-rim com- positional traverses across olivine crystals document different types of zoning. We recognized oliv- ine zones affected by Fo oscillations at very fine scales in the inner cores, rims and/or in intermedi- ate portions of crystals and used them to reconstruct the residence and passage of crystals through different magmatic environments, with P–T–ƒO2 and compositional characteristics con- strained by thermodynamic modeling. The sequence of magmatic environments evidenced by oliv- ine zoning indicate that the pre-GT volcanic period was dominated by injection at shallow crustal levels (􏰃300–200 MPa) of primitive melts, initially moving from a deep storage zone at the crust- mantle boundary. Supply of this magma significantly decreased after the GT eruption, while the dy- namics of magma transfer within the upper portion of the plumbing system were greatly enhanced. The diffusive relaxation of olivine zoning provided the timing of storage and migration of a crystal through different environments. For magmas feeding the ancient (〉45 ka) basaltic activ- ity we retrieved transfer histories that are much longer (up to 􏰃3 years) if compared with those cal- culated for the post-GT basalts (1–9 months). The compositional and temporal dataset presented in this study supports the idea that the GT eruption and the subsequent collapse of the volcanic edi- fice could have caused major changes to the internal structural setting of Pantelleria, creating more favorable conditions for the migration of magmas in the upper portions of the plumbing system.
    Description: Published
    Description: egaa05
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: JCR Journal
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  • 70
    Publication Date: 2021-05-12
    Description: Ischia, a volcanic island located 18 miles SW of Naples (Southern Italy), is a densely populated active caldera that last erupted in AD 1302. Melt inclusions in phenocrysts of the Vateliero and Cava Nocelle shoshonite^latite eruptive products (6th to 4th centuries BC) constrain the structure and nature of the Ischia deep magmatic feeding system.Their geochemical characteristics make Ischia a natural borehole for probing the physico-chemical conditions of magma generation in mantle contaminated by slab-derived fluids or melts, largely dominated by CO2.Volatile concentrations in olivine-hosted melt inclusions require gas^melt equilibria at between 3 and 18 km depth. In agreement with what has already been demonstrated at the other neighboring Neapolitan volcanoes (Procida, Campi Flegrei caldera and Somma^Vesuvius volcanic complex), a major crystallization depth at 8^10 km has been identified.The analyzed melt inclusions provide clear evidence for CO2-dominated gas fluxing and consequent dehydration of magma batches stagnating at crustal discontinuities. Gas fluxing is further supported by selective enrichment in K owing to fluid-transfer during magma differentiation.This takes place under oxidized conditions (Fe3þ /Fe 0·3) that can be fixed by an equimolar proportion of divalent and trivalent iron in the melt if post-entrapment crystallization of the host olivine is discarded.The melt inclusion data, together with data from the literature for other Neapolitan volcanoes, show that magmatism and volcanism in the Neapolitan area, despite differences in composition and eruption dynamics, are closely linked to supercritical CO2-rich fluids. These fluids are produced by devolatilization of subducting terrigenous^pelagic metasediments and infiltrate the overlying mantle wedge, generate magmas and control their ascent up to eruption. Geochemical characteristics of Ischia and the other Neapolitan volcanoes reveal that the extent of fluid or melt contamination of the pre-subduction asthenospheric mantle wedge was similar among these volcanoes. However, differences in the isotopic compositions of the erupted magmas (more enriched in radiogenic Sr at Ischia, Campi Flegrei and Somma^Vesuvius with respect to Procida) and the amount of H2O in the plumbing system of these volcanoes (almost double at Ischia, Campi Flegrei and Somma^Vesuvius than at Procida) reflect the different flow-rates of deep slab-derived fluids or melts through the mantle wedge, which, in turn, control the amount of generated magma.The high bulk permeability of the lithosphere below Ischia, Campi Flegrei and Somma^Vesuvius, determined by the occurrence of intersecting NW^SE and NE^SW regional fault systems, favours fluid ascent and accumulation at crustal levels, with consequent larger magma production and storage than at Procida, located along the NE^SW system.
    Description: Published
    Description: 951-984
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: 3V. Proprietà chimico-fisiche dei magmi e dei prodotti vulcanici
    Description: 4V. Processi pre-eruttivi
    Description: 6A. Geochimica per l'ambiente e geologia medica
    Description: JCR Journal
    Keywords: CO2-fluxing ; melt inclusions ; redox state ; trachybasalts
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 71
    Publication Date: 2021-06-21
    Description: Sulphur behaviour and variations in redox conditions during magma differentiation and degassing in the Mt Etna (Italy) volcanic system have been explored by integrating the study of olivine-hosted melt inclusions (MIs) with an experimental survey of sulphur solubility in hydrous basaltic magmas. Sulphur solubility experiments were performed at conditions relevant to the Etnean plumbing system (1200 C, 200MPa and oxygen fugacity between NNOþ0 2 and NNOþ1 7, with NNO being the nickel–nickel oxide buffer), and their results confirm the important control of oxygen fugacity (fO2) on S abundance in mafic magmas and on S partitioning between fluid and melt phases (DSfluid/melt). The observed DSfluid/melt value increases from 5164 to 14666 when fO2 decreases from NNOþ1 760 5 to NNOþ0 3. Based on the calculated DSfluid/melt and a careful selection of previously published data, an empirical model is proposed for basaltic magmas to predict the variation of DSfluid/melt values with variations in P (25–300 MPa), T (1030–1200 C) and fO2 (between NNO– 0 8 and NNOþ2 4). Olivine-hosted melt inclusions (Fo89-91) from tephra of the prehistoric (4 ka BP) sub-plinian picritic eruption, named FS (‘Fall Stratified’), have been investigated for their major element compositions, volatile contents and iron speciation (expressed as Fe3þ/PFe ratio). These primitive MIs present S content from 235677 to 34456168 ppm, and oxygen fugacity values, estimated from Fe3þ/PFe ratios, range from NNOþ0 760 2 to NNOþ1 660 2. Iron speciation has also been investigated in more evolved and volatile-poorer Etnean MIs. The only primitive melt inclusion from the Mt Spagnolo eruption (4–15 ka BP) presents a S content of 1515649ppm and an estimated fO2 of NNOþ1 460 1. The more evolved MIs (from 2002–2003, 2006, 2008–2009 and 2013 eruptions) have S content lower than 500 ppm, and their Fe3þ/RFe ratios result in fO2 between NNO– 0 960 1 and NNOþ0 460 1. Redox conditions and S behaviour in Etnean magmas during degassing and fractional crystallization were modelled coupling MELTS code with our empirical DSfluid/melt model. Starting from an FS-type magma composition and upon decrease of T and P, fractional crystallization of olivine, clinopyroxene, spinel and plagioclase causes a significant fO2 decrease. The fO2 reduction, in turn, causes a decrease in sulphur solubility and an increase in DSfluid/melt, promoting S exsolution during magma ascent, which further enhances the reduction of fO2. For the evolved MIs of 2002–2013 eruptions, magma differentiation may therefore have played a crucial role in decreasing redox conditions and favouring efficient S degassing. Differently, during the unusual FS eruption, only limited melt evolution is observed and S exsolution seems to have been triggered by a major pressure decrease accompanied by H2O and CO2 exsolution during fast magmatic ascent.
    Description: Published
    Description: egaa095
    Description: 4V. Processi pre-eruttivi
    Description: JCR Journal
    Keywords: melt inclusions ; sulphur solubility experiments ; XANES ; Mt. Etna ; 04.08. Volcanology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 72
    Publication Date: 2020-10-16
    Description: The behaviour of tsunami waves at any location depends on the local morphology of the coasts, the encountered bathymetric features, and the characteristics of the source. However, the importance of accurately modelling the geometric properties of the causative fault for simulations of seismically induced tsunamis is rarely addressed. In this work, we analyse the effects of using two different geometric models of the subduction interface of the Calabrian Arc (southern Italy, Ionian Sea) onto the simulated tsunamis: a detailed 3-D subduction interface obtained from the interpretation of a dense network of seismic reflection profiles, and a planar interface that roughly approximates the 3-D one. These models can be thought of as representing two end-members of the level of knowledge of fault geometry. We define three hypothetical earthquake ruptures of different magnitudes (Mw 7.5, 8.0, 8.5) on each geometry. The resulting tsunami impact is evaluated at the 50-m isobath in front of coastlines of the central and eastern Mediterranean. Our results show that the source geometry imprint is evident on the tsunami waveforms, as recorded at various distances and positions relative to the source. The absolute differences in maximum and minimum wave amplitudes locally exceed one metre, and the relative differences remain systematically above 20 per cent with peaks over 40 per cent. We also observe that tsunami energy directivity and focusing due to bathymetric waveguides take different paths depending on which fault is used. Although the differences increase with increasing earthquake magnitude, there is no simple rule to anticipate the different effects produced by these end-member models of the earthquake source. Our findings suggest that oversimplified source models may hinder our fundamental understanding of the tsunami impact and great care should be adopted when making simplistic assumptions regarding the appropriateness of the planar fault approximation in tsunami studies. We also remark that the geological and geophysical 3-D fault characterization remains a crucial and unavoidable step in tsunami hazard analyses.
    Description: Published
    Description: 1805–1819
    Description: 3T. Sorgente sismica
    Description: 6T. Studi di pericolosità sismica e da maremoto
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 73
    Publication Date: 2021-04-14
    Description: The scaling of earthquake parameters with seismic moment and its interpretation in terms of self- similarity is still debated in the literature. We address this question by examining a worldwide compilation of corner frequency-based and elastic rebound theory (ERT)-based fault slip, area and stress drop values for earthquakes ranging in magnitude from -0.7 to 7.8. We find that corner frequency estimates of slip (and stress drop) scale differently than those inferred from the ERT approach, where the latter deviates from the generally accepted constant stress drop behavior of so- called self-similar scaling models. We also find that average slips from finite-source models are consistent with corner frequency scaling, whereas peak slip values are more consistent with the ERT scaling. The different scaling of corner frequency- and ERT-based estimates of slip and stress drop with earthquake size is interpreted in terms of heterogeneity of the rupture process. ERT-based estimates of stress drop decrease with seismic moment suggesting a self-affine behavior. Despite the inferred heterogeneity at all scales, we do not observe a clear effect on the Brune stress drop scaling with earthquake size.
    Description: Published
    Description: 1771–1781
    Description: 2T. Deformazione crostale attiva
    Description: JCR Journal
    Keywords: Earthquake dynamics ; Earthquake source observations ; Dynamics and mechanics of faulting ; 04.06. Seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 74
    Publication Date: 2020-11-11
    Description: This article has been accepted for publication in Geophysical Journal International ©: 2021 The Author(s) 2020. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.
    Description: In this short paper we show how to use the classical maximum likelihood estimation procedure for the b-value of the Gutenberg–Richter law for catalogues with different levels of completeness. With a simple correction, that is subtracting the relative completeness level to each magnitude, it becomes possible to use the classical approach. Moreover, this correction allows to adopt the testing procedures, initially made for catalogues with a single level of completeness, for catalogues with different levels of completeness too.
    Description: Published
    Description: 337–339
    Description: 6T. Studi di pericolosità sismica e da maremoto
    Description: JCR Journal
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  • 75
    Publication Date: 2020-12-21
    Description: This article has been accepted for publication in Geophysical Journal International. Published by Oxford University Press on behalf of the Royal Astronomical Society.
    Description: The classical procedure of the Probabilistic Seismic Hazard Analysis (PSHA) requires a Poissonian distribution of earthquakes. Seismic catalogs follow a Poisson distribution just after the application of a declustering algorithm that leaves only one earthquake for each seismic sequence (usually the stronger, i.e. the main shock). Removing earthquakes from the seismic catalogs leads to underestimation of the annual rates of the events and consequently associate with low seismic hazard as indicated by several studies. In this study, we aim investigating the performance of two declustering methods on the Italian instrumental catalog and the impact of declustering on estimation of the b-value and on the seismic hazard analysis. To this end, first the spatial variation in the seismicity rate was estimated from the declustered catalogs using the adaptive smoothed seismicity approach, considering small earthquakes (Mw≥3.0). We then corrected the seismicity rates using new approach that allows for counting all events in the complete seismic catalog by simply changing the magnitude frequency distribution. The impact of declustering on seismic hazard analysis is illustrated using PSHA maps in terms of peak ground acceleration (PGA) and spectral acceleration (SA) in 2 s, with 10% and 2% probability of exceedance in 50 years, for Italy. We observed that the hazard calculated from the declustered catalogs was always lower than the hazard computed using the complete catalog. These results are in agreement with previous results obtained in different parts of the world.
    Description: Published
    Description: 1174–1187
    Description: 6T. Studi di pericolosità sismica e da maremoto
    Description: JCR Journal
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  • 76
    Publication Date: 2021-05-12
    Description: We have constructed a 3-D shear wave velocity (Vs) model for the crust and uppermost mantle beneath the Middle East using Rayleigh wave records obtained from ambient-noise cross-correlations and regional earthquakes. We combined one decade of data collected from 852 permanent and temporary broad-band stations in the region to calculate group-velocity dispersion curves. A compilation of 〉54 000 ray paths provides reliable group-velocity measurements for periods between 2 and 150 s. Path-averaged group velocities calculated at different periods were inverted for 2-D group-velocity maps. To overcome the problem of heterogeneous ray coverage, we used an adaptive grid parametrization for the group-velocity tomographic inversion. We then sample the period-dependent group-velocity field at each cell of a predefined grid to generate 1-D group-velocity dispersion curves, which are subsequently inverted for 1-D Vs models beneath each cell and combined to approximate the 3-D Vs structure of the area. The Vs model shows low velocities at shallow depths (5–10 km) beneath the Mesopotamian foredeep, South Caspian Basin, eastern Mediterranean and the Black Sea, in coincidence with deep sedimentary basins. Shallow high-velocity anomalies are observed in regions such as the Arabian Shield, Anatolian Plateau and Central Iran, which are dominated by widespread magmatic exposures. In the 10–20 km depth range, we find evidence for a band of high velocities (〉4.0 km s–1) along the southern Red Sea and Arabian Shield, indicating the presence of upper mantle rocks. Our 3-D velocity model exhibits high velocities in the depth range of 30–50 km beneath western Arabia, eastern Mediterranean, Central Iranian Block, South Caspian Basin and the Black Sea, possibly indicating a relatively thin crust. In contrast, the Zagros mountain range, the Sanandaj-Sirjan metamorphic zone in western central Iran, the easternmost Anatolian plateau and Lesser Caucasus are characterized by low velocities at these depths. Some of these anomalies may be related to thick crustal roots that support the high topography of these regions. In the upper mantle depth range, high-velocity anomalies are obtained beneath the Arabian Platform, southern Zagros, Persian Gulf and the eastern Mediterranean, in contrast to low velocities beneath the Red Sea, Arabian Shield, Afar depression, eastern Turkey and Lut Block in eastern Iran. Our Vs model may be used as a new reference crustal model for the Middle East in a broad range of future studies.
    Description: Published
    Description: 1349-1365
    Description: 1T. Struttura della Terra
    Description: JCR Journal
    Keywords: 04.01. Earth Interior ; 04.06. Seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 77
    Publication Date: 2021-07-23
    Description: Marine aquaculture holds great promise for meeting increasing demand for healthy protein that is sustainably produced, but reaching necessary production levels will be challenging. The ecosystem approach to aquaculture is a framework for sustainable aquaculture development that prioritizes multiple-stakeholder participation and spatial planning. These types of approaches have been increasingly used to help guide sustainable, persistent, and equitable aquaculture planning, but most countries have difficulties in setting or meeting longer-term development goals. Scenario analysis (SA) for future planning uses similar approaches and can complement holistic methods, such as the ecosystem approach to aquaculture framework, by providing a temporal analogue to the spatially robust design. Here we define the SA approach to planning in aquaculture, outline how SA can benefit aquaculture planning, and review how this tool is already being used. We track the use of planning tools in the 20 International Council for the Exploration of the Sea member nations, with particular attention given to Norway’s development goals to 2050. We conclude that employing a combination of an ecosystem framework with scenario analyses may help identify the scale of development aquaculture goals over time, aid in evaluating the feasibility of the desired outcomes, and highlight potential social-ecological conflicts and trade-offs that may otherwise be overlooked.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 78
    Publication Date: 2020-06-17
    Description: Petrological and geochemical (major element, trace element, Sr–Nd isotope) data for recent (〈5 kyr old) basalts that sporadically erupt on the western flank of Piton de la Fournaise (PdF), one of the most active volcanoes on Earth, allow the tracking of magma transfer and evolution from mantle to crustal depths. In the western peripheral area of PdF we document the broadly synchronous eruptions of (1) primitive olivine and olivine–clinopyroxene transitional basalts with tholeiitic affinity 30 that are closely associated in space with (2) transitional olivine basalts with alkaline affinity, and (3) hybrid lavas, intermediate between the ‘alkaline’ and the ‘tholeiitic’ end-members. The composition of the latter overlaps with that of the lavas frequently erupted from the conduit system feeding the main summit cone. AlphaMELTS modelling, and fluid inclusion and clinopyroxene barometry, constrain the conditions of magma storage at 10–30 km, and the ascent of magma from the upper 35 mantle to the shallow crustal plumbing system. Variable degrees of mantle melting, together with minor source heterogeneity and contamination with cumulate-derived partial melts, contribute to the diversity of PdF magmas. However, all these processes do not represent the dominant factors that produce the large variability we found in major element composition. Indeed, the composition of basalts erupted from PdF peripheral centers is strongly controlled by polybaric olivine–clinopyr- 40 oxene fractionation at pressures higher than 3 kbar. Crystal textures and geochemical modelling suggest that fast magma ascent is critical to prevent clinopyroxene dissolution. Conversely, longlasting magma stagnation promotes pyroxene resorption and magma differentiation. ‘Central’ eruptions occurring close to the PdF summit cone emit variably more evolved melts, which result from olivine–clinopyroxene–plagioclase differentiation at intermediate–shallow pressure (〈3 kbar and in most cases 〈1 kbar). Deep and extensive magma mixing before injection into the crustal magma conduit system, located below the summit region, results in the apparent homogeneity of basalts erupted from the central area. As regards ‘peripheral’ eruptions, deep-seated stagnation of basaltic melts and differentiation at the mantle–crust transition zone (c. 4 kbar) produces a range of 5 magma compositions. We demonstrate that rapid magma ascent from deep-seated reservoirs can bypass the central plumbing system. The eruptions of these magmas both in the central area and on the densely populated flanks have major consequences in terms of volcanic hazard at PdF.
    Description: Published
    Description: 1717–1752
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: JCR Journal
    Keywords: transitional basalts ; clinopyroxene crystallization and resorption ; mantle–crust underplating
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 79
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    Unknown
    Oxford University Press
    In:  EPIC3The Natural History of the Crustacea, Vol. 6: Reproductive Biology, New York, U.S.A., Oxford University Press, 30 p., pp. 277-306, ISBN: 9780190688554
    Publication Date: 2021-02-24
    Description: Due to an exceptional variety of habitats, body plans, and lifestyles, crustaceans exhibit a wide array of mating systems. Some groups engage in simple, pure- search polygamous systems in which males usually search for receptive females. In other groups, males defend valuable resources to attract and/ or guard females to ensure paternity. Some species have developed highly complex systems of harem defense polygyny and monogamy, even cases of sub- and eusociality are reported. The expression of mating systems does not seem to be uniformly correlated to taxonomic affiliation, but is rather diverse within certain groups, suggesting that the evolution of mating systems is largely facilitated by the lifestyle of the species. Despite the broad range of mating systems in crustaceans, and although some groups have been studied comparably well, there remains a lack of knowledge about the behavioral and sexual biology of many species. In the light of the high diversity of lifestyles, mating systems, and habitats of certain groups, crustacean species would be ideal models to unravel the evolution of reproductive strategies and social behaviors.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Inbook , peerRev
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  • 80
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 27-47 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Owing to the rapid development of in vivo applications for non-viral gene delivery vectors, it is necessary to have a better understanding of how the structure-activity relationships of these lipid-DNA complexes are affected by their environment. Indeed, research in gene therapy first focused on in vitro cell culture studies to determine the mechanisms involved in the delivery of DNA into the cell. New biophysical techniques such as electron microscopy and X-ray diffraction have been developed to discern the structure of the lipid-DNA complex. However, further studies have revealed discrepancies between optimal lipid-DNA formulations for in vitro transfection and for in vivo administration of these vectors. Furthermore, some immune stimulatory effects have been associated with in vivo lipid-DNA administration. This review summarizes the current state of knowledge on in vitro and in vivo lipid-DNA complex transfections. New prospects of vectors for in vivo gene transfer are also discussed.
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  • 81
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 81-103 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Hundreds of acetyltransferases exist. All use a common acetyl donor-acetyl coenzyme A-and each exhibits remarkable specificity for acetyl acceptors, which include small molecules and proteins. Analysis of the primary sequences of these enzymes indicates that they can be sorted into several superfamilies. This review covers the three-dimensional structures of members of one of these superfamilies, now referred to in the literature as the GCN5-related N-acetyltransferases (GNAT), reflecting the importance of one functional category, the histone acetyltransferases. Despite the diversity of substrate specificities, members of the GNAT superfamily demonstrate remarkable similarity in protein topology and mode of acetyl coenzyme A binding, likely reflecting a conserved catalytic mechanism.
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  • 82
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 49-79 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Protein kinase C homology-1 and -2, FYVE, and pleckstrin homology domains are ubiquitous in eukaryotic signal transduction and membrane-trafficking proteins. These domains regulate subcellular localization and protein function by binding to lipid ligands embedded in cell membranes. Structural and biochemical analysis of these domains has shown that their molecular mechanisms of membrane binding depend on a combination of specific and nonspecific interactions with membrane lipids. In vivo studies of green fluorescent protein fusions have highlighted the key roles of these domains in regulating protein localization to plasma and internal membranes in cells.
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  • 83
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 1-26 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Although the force fields and interaction energies that control protein behavior can be inferred indirectly from equilibrium and kinetic measurements, recent developments have made it possible to quantify directly (a) the ranges, magnitudes, and time dependence of the interaction energies and forces between biological materials; (b) the mechanical properties of isolated proteins; and (c) the strength of single receptor-ligand bonds. This review describes recent results obtained by using the atomic force microscope, optical tweezers, the surface force apparatus, and micropipette aspiration to quantify short-range protein-ligand interactions and the long-range, nonspecific forces that together control protein behavior. The examples presented illustrate the power of force measurements to quantify directly the force fields and energies that control protein behavior.
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  • 84
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 183-212 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Cys2His2 zinc fingers are one of the most common DNA-binding motifs found in eukaryotic transcription factors. These proteins typically contain several fingers that make tandem contacts along the DNA. Each finger has a conserved betabetaalpha structure, and amino acids on the surface of the alpha-helix contact bases in the major groove. This simple, modular structure of zinc finger proteins, and the wide variety of DNA sequences they can recognize, make them an attractive framework for attempts to design novel DNA-binding proteins. Several studies have selected fingers with new specificities, and there clearly are recurring patterns in the observed side chain-base interactions. However, the structural details of recognition are intricate enough that there are no general rules (a "recognition code") that would allow the design of an optimal protein for any desired target site. Construction of multifinger proteins is also complicated by interactions between neighboring fingers and the effect of the intervening linker. This review analyzes DNA recognition by Cys2His2 zinc fingers and summarizes progress in generating proteins with novel specificities from fingers selected by phage display.
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  • 85
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 327-359 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract This review describes how kinetic experiments using techniques with dramatically improved time resolution have contributed to understanding mechanisms in protein folding. Optical triggering with nanosecond laser pulses has made it possible to study the fastest-folding proteins as well as fundamental processes in folding for the first time. These include formation of alpha-helices, beta-sheets, and contacts between residues distant in sequence, as well as overall collapse of the polypeptide chain. Improvements in the time resolution of mixing experiments and the use of dynamic nuclear magnetic resonance methods have also allowed kinetic studies of proteins that fold too fast (〉 103 s-1) to be observed by conventional methods. Simple statistical mechanical models have been extremely useful in interpreting the experimental results. One of the surprises is that models originally developed for explaining the fast kinetics of secondary structure formation in isolated peptides are also successful in calculating folding rates of single domain proteins from their native three-dimensional structure.
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  • 86
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 411-438 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract ClC-type chloride channels are ubiquitous throughout the biological world. Expressed in nearly every cell type, these proteins have a host of biological functions. With nine distinct homologues known in eukaryotes, the ClCs represent the only molecularly defined family of chloride channels. ClC channels exhibit features of molecular architecture and gating mechanisms unprecedented in other types of ion channels. They form two-pore homodimers, and their voltage-dependence arises not from charged residues in the protein, but rather via coupling of gating to the movement of chloride ions within the pore. Because the functional characteristics of only a few ClC channels have been studied in detail, we are still learning which properties are general to the whole family. New approaches, including structural analyses, will be crucial to an understanding of ClC architecture and function.
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  • 87
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    Annual Review of Biophysics and Biomolecular Structure 29 (2000), S. 439-461 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract In the past decade, a general design for sequence-specific minor groove ligands has evolved, based on the natural products distamycin and netropsin. By utilizing a basic set of design rules for connecting pyrrole, imidazole, and hydroxypyrrole modules, new ligands can be prepared to target almost any sequence of interest with both high affinity and specificity. In this review we present the design rules with a brief history of how they evolved. The structural basis for sequence-specific recognition is explained, together with developments that allow linking of recognition modules that enable targeting of long DNA sequences. Examples of the affinity and specificity that can be achieved with a number of variations on the basic design are given. Recently these molecules have been used to compete with proteins both in vitro and in vivo, and a brief description of the experimental results are given.
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  • 88
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    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 129-155 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract NMR spin relaxation spectroscopy is a powerful approach for characterizing intramolecular and overall rotational motions in proteins. This review describes experimental methods for measuring laboratory frame spin relaxation rate constants by high-resolution solution-state NMR spectroscopy, together with theoretical approaches for interpreting spin relaxation data in order to quantify protein conformational dynamics on picosecond-nanosecond time scales. Recent applications of these techniques to proteins are surveyed, and investigations of the contribution of conformational chain entropy to protein function are highlighted. Insights into the dynamical properties of proteins obtained from NMR spin relaxation spectroscopy are compared with results derived from other experimental and theoretical techniques.
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  • 89
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    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 157-171 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The fusion of vesicles with target membranes is controlled by a complex network of protein-protein and protein-lipid interactions. Structures of the SNARE complex, synaptotagmin III, nSec1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effectors provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models.
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  • 90
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 173-189 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Considerable recent progress has been made in the field of ab initio protein structure prediction, as witnessed by the third Critical Assessment of Structure Prediction (CASP3). In spite of this progress, much work remains, for the field has yet to produce consistently reliable ab initio structure prediction protocols. In this work, we review the features of current ab initio protocols in an attempt to highlight the foundations of recent progress in the field and suggest promising directions for future work.
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  • 91
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    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 191-209 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Species and tissue-specific isozymes of phosphorylase display differences in regulatory properties consistent with their distinct roles in particular organisms and tissues. In this review, we compare crystallographic structures of regulated and unregulated phosphorylases, including maltodextrin phosphorylase (MalP) from Escherichia coli, glycogen phosphorylase from yeast, and mammalian isozymes from muscle and liver tissues. Mutagenesis and functional studies supplement the structural work and provide insights into the structural basis for allosteric control mechanisms. MalP, a simple, unregulated enzyme, is contrasted with the more complicated yeast and mammalian phosphorylases that have evolved regulatory sites onto the basic catalytic architecture. The human liver and muscle isozymes show differences structurally in their means of invoking allosteric activation. Phosphorylation, though common to both the yeast and mammalian enzymes, occurs at different sites and activates the enzymes by surprisingly different mechanisms.
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  • 92
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Computer modeling has been developed and widely applied in studying molecules of biological interest. The force field is the cornerstone of computer simulations, and many force fields have been developed and successfully applied in these simulations. Two interesting areas are (a) studying enzyme catalytic mechanisms using a combination of quantum mechanics and molecular mechanics, and (b) studying macromolecular dynamics and interactions using molecular dynamics (MD) and free energy (FE) calculation methods. Enzyme catalysis involves forming and breaking of covalent bonds and requires the use of quantum mechanics. Noncovalent interactions appear ubiquitously in biology, but here we confine ourselves to review only noncovalent interactions between protein and protein, protein and ligand, and protein and nucleic acids.
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  • 93
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 245-269 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Molecular chaperones are required to assist folding of a subset of proteins in Escherichia coli. We describe a conceptual framework for understanding how the GroEL-GroES system assists misfolded proteins to reach their native states. The architecture of GroEL consists of double toroids stacked back-to-back. However, most of the fundamentals of the GroEL action can be described in terms of the single ring. A key idea in our framework is that, with coordinated ATP hydrolysis and GroES binding, GroEL participates actively by repeatedly unfolding the substrate protein (SP), provided that it is trapped in one of the misfolded states. We conjecture that the unfolding of SP becomes possible because a stretching force is transmitted to the SP when the GroEL particle undergoes allosteric transitions. Force-induced unfolding of the SP puts it on a higher free-energy point in the multidimensional energy landscape from which the SP can either reach the native conformation with some probability or be trapped in one of the competing basins of attraction (i.e., the SP undergoes kinetic partitioning). The model shows, in a natural way, that the time scales in the dynamics of the allosteric transitions are intimately coupled to folding rates of the SP. Several scenarios for chaperonin-assisted folding emerge depending on the interplay of the time scales governing the cycle. Further refinement of this framework may be necessary because single molecule experiments indicate that there is a great dispersion in the time scales governing the dynamics of the chaperonin cycle.
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  • 94
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 31 (2002), S. 1-44 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
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  • 95
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 421-455 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract The mammalian thioredoxins are a family of small (approximately 12 kDa) redox proteins that undergo NADPH-dependent reduction by thioredoxin reductase and in turn reduce oxidized cysteine groups on proteins. The two main thioredoxins are thioredoxin-1, a cytosolic and nuclear form, and thioredoxin-2, a mitochondrial form. Thioredoxin-1 has been studied more. It performs many biological actions including the supply of reducing equivalents to thioredoxin peroxidases and ribonucleotide reductase, the regulation of transcription factor activity, and the regulation of enzyme activity by heterodimer formation. Thioredoxin-1 stimulates cell growth and is an inhibitor of apoptosis. Thioredoxins may play a role in a variety of human diseases including cancer. An increased level of thioredoxin-1 is found in many human tumors, where it is associated with aggressive tumor growth. Drugs are being developed that inhibit thioredoxin and that have antitumor activity.
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  • 96
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 31 (2002), S. 177-206 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Early NMR structural studies of serum lipoproteins were based on 1H, 13C, 31P, and 2H studies of lipid components. From the early studies information on composition, lipid chain dynamics and order parameters, and monolayer organization resulted. More recently, selective or complete isotopic labeling techniques, combined with multidimensional NMR spectroscopy, have resulted in structural information of apoprotein fragments. Finally, use of heteronuclear three- and four-dimensional experiments have yielded solution structures and protein-lipid interactions of intact apolipoproteins C-I, C-II, and A-I.
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  • 97
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 31 (2002), S. 235-256 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract During the course of their biological function, proteins undergo different types of structural rearrangements ranging from local to large-scale conformational changes. These changes are usually triggered by their interactions with small-molecular-weight ligands or other macromolecules. Because binding interactions occur at specific sites and involve only a small number of residues, a chain of cooperative interactions is necessary for the propagation of binding signals to distal locations within the protein structure. This process requires an uneven structural distribution of protein stability and cooperativity as revealed by NMR-detected hydrogen/deuterium exchange experiments under native conditions. The distribution of stabilizing interactions does not only provide the architectural foundation to the three-dimensional structure of a protein, but it also provides the required framework for functional cooperativity. In this review, the statistical thermodynamic linkage between protein stability, functional cooperativity, and ligand binding is discussed.
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  • 98
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    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 271-306 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Proteins are designed to function in environments crowded by cosolutes, but most studies of protein equilibria are conducted in dilute solution. While there is no doubt that crowding changes protein equilibria, interpretations of the changes remain controversial. This review combines experimental observations on the effect of small uncharged cosolutes (mostly sugars) on protein stability with a discussion of the thermodynamics of cosolute-induced nonideality and critical assessments of the most commonly applied interpretations. Despite the controversy surrounding the most appropriate manner for interpreting these effects of thermodynamic nonideality arising from the presence of small cosolutes, experimental advantage may still be taken of the ability of the cosolute effect to promote not only protein stabilization but also protein self-association and complex formation between dissimilar reactants. This phenomenon clearly has potential ramifications in the cell, where the crowded environment could well induce the same effects.
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  • 99
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 329-359 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Nuclear receptors (NRs) form a superfamily of ligand-inducible transcription factors composed of several domains. Recent structural studies focused on domain E, which harbors the ligand-binding site and the ligand-dependent transcription activation function AF-2. Structures of single representatives in an increasing number of various complexes as well as new structures of further NRs addressed issues such as discrimination of ligands, superagonism, isotype specificity, and partial agonism. Until today, one unique transcriptionally active form of domain E was determined; however, divergent tertiary structures of apo-forms and transcriptionally inactive forms are known. Thus, recent results link the transformation of NRs upon ligand binding to principles of protein folding. Furthermore, the ensemble of NR structures, including those of DNA-binding domains, provides one of the foundations for the understanding of interactions with transcription intermediary factors up to the characterization of the link between NR complexes and the basal transcriptional machinery at the structural level.
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  • 100
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 30 (2001), S. 397-420 
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Microtubules are polymers that are essential for, among other functions, cell transport and cell division in all eukaryotes. The regulation of the microtubule system includes transcription of different tubulin isotypes, folding of alpha/beta-tubulin heterodimers, post-translation modification of tubulin, and nucleotide-based microtubule dynamics, as well as interaction with numerous microtubule-associated proteins that are themselves regulated. The result is the precise temporal and spatial pattern of microtubules that is observed throughout the cell cycle. The recent high-resolution analysis of the structure of tubulin and the microtubule has brought new insight to the study of microtubule function and regulation, as well as the mode of action of antimitotic drugs that disrupt normal microtubule behavior. The combination of structural, genetic, biochemical, and biophysical data should soon give us a fuller understanding of the exquisite details in the regulation of the microtubule cytoskeleton.
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