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  • Wiley  (77,683)
  • Nature Publishing Group
  • 2010-2014  (57,890)
  • 2005-2009  (24,568)
  • 2013  (34,864)
  • 2010  (23,026)
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  • 1
    Publication Date: 2019-03-08
    Description: Coccolithophores have influenced the global climate for over 200 million years1. These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems2. They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering themvisible fromspace3.Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean4. Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate thatE. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
    Repository Name: EPIC Alfred Wegener Institut
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  • 2
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    Wiley
    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 118(4), pp. 2546-2556, ISSN: 0148-0227
    Publication Date: 2016-11-15
    Description: The roughness of a glacier bed has high importance for the estimation of the sliding velocity and can also provide valuable insights into the dynamics and history of ice sheets, depending on scale. Measurement of basal properties in present-day ice sheets is restricted to ground-penetrating radar and seismics, with surveys retrieving relatively coarse data sets. Deglaciated areas, like the Barents Sea, can be surveyed by shipborne 2-D and 3-D seismics and multibeam sonar and provide the possibility of studying the basal roughness of former ice sheets and ice streams with high resolution. Here, for the first time, we quantify the subglacial roughness of the former Barents Sea ice sheet by estimating the spectral roughness of the basal topography. We also make deductions about the past flow directions by investigating how the roughness varies along a 2-D line as the orientation of the line changes. Lastly, we investigate how the estimated basal roughness is affected by the resolution of the basal topography data set by comparing the spectral roughness along a cross section using various sampling intervals. We find that the roughness typically varies on a similar scale as for other previously marine-inundated areas in West Antarctica, with subglacial troughs having very low roughness, consistent with fast ice flow and high rates of basal erosion. The resolution of the data set seems to be of minor importance when comparing roughness indices calculated with a fixed profile length. A strong dependence on track orientation is shown for all wavelengths, with profiles having higher roughness across former flow directions than along them.
    Repository Name: EPIC Alfred Wegener Institut
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  • 3
    Publication Date: 2017-01-30
    Repository Name: EPIC Alfred Wegener Institut
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  • 4
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    Wiley
    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 115, pp. F04032, ISSN: 0148-0227
    Publication Date: 2016-11-14
    Description: Recent advances in three‐dimensional (3D) imaging of snow and firn combined with numerical modeling of flow through complex geometries have greatly improved the ability to predict permeability values based on microstructure. In this work, we combined 3D reconstructions of polar firn microstructure obtained from microcomputed tomography (mCT) and a 3D lattice‐Boltzmann (LB) model of air flow. We compared the modeled results to measurements of permeability for polar firn with a wide range of grain and pore‐scale characteristics. The results show good agreement between permeability measurements and calculated permeability values from the LB model over a wide range of sample types. The LB model is better at predicting measured permeability values than traditional empirical equations for polar firn.
    Repository Name: EPIC Alfred Wegener Institut
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  • 5
    Publication Date: 2016-01-18
    Description: From a synthesis of recent oceanic observations and paleo-data it is evident that certain species of giant diatoms including Rhizosolenia spp. Thalassiothrix spp. and Ethmodiscus rex may become concentrated at oceanic frontal zones and subsequently form episodes of mass flux to the sediment. Within the nutrient bearing waters advecting towards frontal boundaries, these species are generally not dominant, but they appear selectively segregated at fronts, and thus may dominate the export flux. Ancient Thalassiothrix diatom mat deposits in the eastern equatorial Pacific and beneath the Polar Front in the Southern Ocean record the highest open ocean sedimentation rates ever documented and represent vast sinks of silica and carbon. Several of the species involved are adapted to a stratified water column and may thrive in Deep Chlorophyll Maxima. Thus in oceanic regions and/or at times prone to enhanced surface water stratification (e.g., during meltwater pulses) they provide a mechanism for generating substantial biomass at depth and its subsequent export with concomitant implications for Si export and C drawdown. This ecology has important implications for ocean biogeochemical models suggesting that more than one diatom “functional type” should be used. In spite of the importance of these giant diatoms for biogeochemical cycling, their large size coupled with the constraints of conventional oceanographic survey schemes and techniques means that they are undersampled. An improved insight into these key species will be an important prerequisite for enhancing our understanding of marine biogeochemical cycling and for assessing the impacts of climate change on ocean export production.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 6
    Publication Date: 2015-10-21
    Repository Name: EPIC Alfred Wegener Institut
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  • 7
    Publication Date: 2019-07-17
    Description: Enhancement of ocean alkalinity using calcium compounds, e.g., lime has been proposed to mitigate further increase of atmospheric CO2 and ocean acidification due to anthropogenic CO2 emissions. Using a global model, we show that such alkalinization has the potential to preserve pH and the saturation state of carbonate minerals at close to today’s values. Effects of alkalinization persist after termination: Atmospheric CO2 and pH do not return to unmitigated levels. Only scenarios in which large amounts of alkalinity (i.e., in a ratio of 2:1 with respect to emitted CO2) are added over large ocean areas can boost oceanic CO2 uptake sufficiently to avoid further ocean acidification on the global scale, thereby elevating some key biogeochemical parameters, e.g., pH significantly above preindustrial levels. Smaller-scale alkalinization could counteract ocean acidification on a subregional or even local scale, e.g., in upwelling systems. The decrease of atmospheric CO2 would then be a small side effect.
    Repository Name: EPIC Alfred Wegener Institut
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  • 8
    Publication Date: 2017-04-04
    Description: Stress can undergo rapid temporal changes in volcanic environments, and this is particularly true during eruptions. We use two independent methods, coda wave interferometry (CWI) and shear wave splitting (SWS) analysis to track stress related wave propagation effects during the waning phase of the 2002 NE fissure eruption at Mt Etna. CWI is used to estimate temporal changes in seismic wave velocity, while SWS is employed to monitor changes in elastic anisotropy. We analyse seismic doublets, detecting temporal changes both in wave velocities and anisotropy, consistent with observed eruptive activity. In particular, syn-eruptive wave propagation changes indicate a depressurization of the system, heralding the termination of the eruption, which occurs three days later.
    Description: Published
    Description: 1779-1788
    Description: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Description: JCR Journal
    Description: reserved
    Keywords: Interferometry ; Seismic anisotropy ; Volcano seismology ; Volcano monitoring ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 9
    Publication Date: 2017-04-04
    Description: Stromboli is a 3000 m high island volcano, rising to 900 m above sea-level. It is the most active volcano of the Aeolian Archipelago in the Tyrrhenian Sea (Italy). Major, large volume (1 km3) sector collapses, four occurring in the last 13 kyr, have played an important role in shaping the north-western flank (Sciara del Fuoco) of the volcano, potentially generating a high-risk tsunami hazard for the Aeolian Islands and the Italian coast. However, smaller volume, partial collapses of the Sciara del Fuoco have been shown to be more frequent tsunami-generating events. One such event occurred on 30 December 2002, when a partial collapse of the north-western flank of the island took place. The resulting landslide generated 10 m high tsunami waves that impacted the island. Multibeam bathymetry, side-scan sonar imaging and visual observations reveal that the landslide deposited 25 to 30 × 106 m3 of sediment on the submerged slope offshore from the Sciara del Fuoco. Two contiguous main deposit facies are recognized: (i) a chaotic, coarse-grained (metre-sized to centimetre-sized clasts) deposit; and (ii) a sand deposit containing a lower, cross-bedded sand layer and an upper structureless pebbly sand bed capped by sea floor ripple bedforms. The sand facies develops adjacent to and partially overlying the coarse deposits. Characteristics of the deposits suggest that they were derived from cohesionless, sandy matrix density flows. Flow rheology and dynamics led to the segregation of the density flow into sand-rich and clast-rich regions. A range of density flow transitions, both in space and in time, caused principally by particle concentration and grain-size partitioning within cohesionless parent flows was identified in the deposits of this relatively small-scale submarine landslide event.
    Description: Published
    Description: 1488-1504
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: reserved
    Keywords: Flow transitions ; island volcano ; subaqueous cohesionless density flows ; submarine landslide deposits ; 04. Solid Earth::04.04. Geology::04.04.04. Marine geology ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 10
    Publication Date: 2017-04-04
    Description: A series of computer microtomography experiments are reported which were performed by using a third-generation synchrotron radiation source on volcanic rocks from various active hazardous volcanoes in Italy and other volcanic areas in the world. The applied technique allowed the internal structure of the investigated material to be accurately imaged at the micrometer scale and three-dimensional views of the investigated samples to be produced as well as three-dimensional quantitative measurements of textural features. Thegeometryof thevesicle (gas-filledvoid) network in volcanic products of both basaltic and trachytic compositions were particularly focused on, as vesicle textures are directly linked to the dynamics of volcano degassing. This investigation provided novel insights into modes of gas exsolution, transport and loss in magmas that were not recognized in previous studies using solely conventional two- dimensional imaging techniques. The results of this study are important to understanding the behaviour of volcanoes and can be combined with other geosciences disciplines to forecast their future activity.
    Description: In press
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: JCR Journal
    Description: reserved
    Keywords: high-resolution three-dimensional imaging ; X-ray computed microtomography ; volcanic eruptions ; volcanic rock textures ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 11
    Publication Date: 2017-04-04
    Description: We present a duration-amplitude procedure for rapid determination of a moment magnitude, Mwpd, for large earthquakes using P-wave recordings at teleseismic distances. Mwpd can be obtained within 20 minutes or less after the event origin time as the required data is currently available in near-real time. The procedure determines apparent source durations, T0, from high-frequency, P-wave records, and estimates moments through integration of broadband displacement waveforms over the interval tP to tP+T0, where tP is the P arrival time. We apply the duration-amplitude methodology to 79 recent, large earthquakes (Global Centroid- Moment Tensor magnitude, MwCMT, 6.6 to 9.3) with diverse source types. The results show that a scaling of the moment estimates for interplate thrust and possibly tsunami earthquakes is necessary to best match MwCMT. With this scaling, Mwpd matches MwCMT typically within ±0.2 magnitude units, with a standard deviation of σ=0.11, equaling or outperforming other approaches to rapid magnitude determination. Furthermore, Mwpd does not exhibit saturation; that is, for the largest events, Mwpd does not systematically underestimate MwCMT. The obtained durations and duration-amplitude moments allow rapid estimation of an energy-to-moment parameter Θ* used for identification of tsunami earthquakes. Our results show that Θ* ≤ -5.7 is an appropriate cutoff for this identification, but also show that neither Θ* nor Mw is a good indicator for tsunamigenic events in general. For these events we find that a reliable indicator is simply that the duration T0 is greater than about 50 sec. The explicit use of the source duration for integration of displacement seismograms, the moment scaling, and other characteristics of the duration-amplitude methodology make it an extension of the widely used, Mwp, rapid-magnitude procedure. The need for a moment scaling for interplate thrust and possibly tsunami earthquakes may have important implications for the source physics of these events.
    Description: DPC-INGV (2007-2009) S3 Project
    Description: Published
    Description: 200-214
    Description: 3.1. Fisica dei terremoti
    Description: JCR Journal
    Description: open
    Keywords: earthquakes, Richter magnitude, seismic moment, seismograms, tsunami,  earthquake­source mechanism ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 12
    Publication Date: 2017-04-04
    Description: Rapid extension and active normal faulting in the western extremity of the Corinth Gulf are accompanied by fast coastal uplift.We investigate Pleistocene uplift west of Aigion, by attempting to date remains of marine terraces and sedimentary sequences by calcareous nannoplankton and U-series analyses. Net uplift initiated recently, due to abandonment of an older rift-bounding fault zone and increase in activity on the presently active, coastal fault zone. This change apparently coincides with an abrupt slow down (or, termination) of secondary fault block tilting within the broader hangingwall block of the older zone, indicated by an angular unconformity that dates in the early part ofMIS10 ( 390–350 ka BP, preferably, in the earlier part of this period). Net uplift driven by the coastal zone resulted in the formation of MIS9c (330 ka) and younger terraces. The formation of the unconformity and the initiation of net uplift coincide temporally with a 300–400 ka unconformity recognized by recent studies in a wide area offshore Aigion i.e. they could be part of an evolutionary event that affected the entirewestern part of the Corinth Rift or, a large area therein. Uplift rate estimates at four locations are discussed with reference to the morphotectonic context of differential uplift of secondary fault blocks, and the context of possible increase in uplift ratewith time. Themost reliable and most useful estimate for uplift rate at the longitude of the studied transect is 1.74–1.85mm/year (time-averaged estimate for the last 240 ka, based on calcareous nannoplankton and sequence-stratigraphic interpretation)
    Description: ‘3HAZ Corinth’ E.U. research project 004043 (GOCE)-3HAZ-Corinth
    Description: Published
    Description: 78 - 104
    Description: 3.2. Tettonica attiva
    Description: JCR Journal
    Description: partially_open
    Keywords: coastal uplift ; marine terraces ; marine sequences ; deformation rate ; Pleistocene ; Corinth Gulf Reef ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 13
    Publication Date: 2017-04-04
    Description: The 2011 Tohoku-oki (Mw 9.1) earthquake is so far the best-observed megathrust rupture, which allowed the collection of unprecedented offshore data. The joint inversion of tsunami waveforms (DART buoys, bottom pressure sensors, coastal wave gauges, and GPS-buoys) and static geodetic data (onshore GPS, seafloor displacements obtained by a GPS/acoustic combination technique), allows us to retrieve the slip distribution on a non-planar fault. We show that the inclusion of near-source data is necessary to image the details of slip pattern (maximum slip ,48 m, up to ,35 m close to the Japan trench), which generated the large and shallow seafloor coseismic deformations and the devastating inundation of the Japanese coast. We investigate the relation between the spatial distribution of previously inferred interseismic coupling and coseismic slip and we highlight the importance of seafloor geodetic measurements to constrain the interseismic coupling, which is one of the key-elements for long-term earthquake and tsunami hazard assessment.
    Description: Published
    Description: 385
    Description: 3.1. Fisica dei terremoti
    Description: N/A or not JCR
    Description: restricted
    Keywords: Tohoku ; Subduction ; Tsunami ; Inverse problem ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 14
    Publication Date: 2019-07-17
    Description: The mid-Piacenzian climate represents the most geologically recent interval of long-term average warmth relative to the last million years, and shares similarities with the climate projected for the end of the 21st century. As such, it represents a natural experiment from which we can gain insight into potential climate change impacts, enabling more informed policy decisions for mitigation and adaptation. Here, we present the first systematic comparison of Pliocene sea surface temperature (SST) between an ensemble of eight climate model simulations produced as part of PlioMIP (Pliocene Model Intercomparison Project) with the PRISM (Pliocene Research, Interpretation and Synoptic Mapping) Project mean annual SST field. Our results highlight key regional and dynamic situations where there is discord between the palaeoenvironmental reconstruction and the climate model simulations. These differences have led to improved strategies for both experimental design and temporal refinement of the palaeoenvironmental reconstruction.
    Repository Name: EPIC Alfred Wegener Institut
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  • 15
    Publication Date: 2019-07-17
    Description: Comparing simulations of key warm periods in Earth history with contemporaneous geological proxy data is a useful approach for evaluating the ability of climate models to simulate warm, high-CO2 climates that are unprecedented in the more recent past. Here we use a global data set of confidence-assessed, proxy-based temperature estimates and biome reconstructions to assess the ability of eight models to simulate warm terrestrial climates of the Pliocene epoch. The Late Pliocene, 3.6–2.6 million years ago, is an accessible geological interval to understand climate processes of a warmer world. We show that model-predicted surface air temperatures reveal a substantial cold bias in the Northern Hemisphere. Particularly strong data–model mismatches in mean annual temperatures (up to 18 °C) exist in northern Russia. Our model sensitivity tests identify insufficient temporal constraints hampering the accurate configuration of model boundary conditions as an important factor impacting on data–model discrepancies. We conclude that to allow a more robust evaluation of the ability of present climate models to predict warm climates, future Pliocene data–model comparison studies should focus on orbitally defined time slices.
    Repository Name: EPIC Alfred Wegener Institut
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  • 16
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    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 40(22), pp. 5882-5887, ISSN: 0094-8276
    Publication Date: 2019-07-17
    Description: Optical televiewer luminosity logs are compared with densities measured gravimetrically on 520 snow, firn and ice samples from two locations of similar annual temperature (~-14 °C) and contrasting accumulation rates (0.23 and 0.43 m w.e. per year) on the Roi Baudouin Ice Shelf, Antarctica. At the scale of ≥10-1 m, an inverse exponential relationship (R2 = 0.96) is recorded between density and luminosity, indicating (i) that OPTV luminosity provides an effective proxy for density at such ice shelves, and (ii) that densities may be reconstructed from boreholes drilled elsewhere by hot water without the need for core material. Our analysis also suggests that this relationship may hold for newly-formed ice as well as for snow and firn. At the scale of ≤10-1 m, both luminosity and density show similar patterns, but precise correlation is confounded by detailed differences between the two records.
    Repository Name: EPIC Alfred Wegener Institut
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  • 17
    Publication Date: 2014-04-02
    Description: Over the last decade, several hundred seals have been equipped with conductivity-temperature-depth sensors in the Southern Ocean for both biological and physical oceanographic studies. A calibrated collection of seal-derived hydrographic data is now available, consisting of more than 165,000 profiles. The value of these hydrographic data within the existing Southern Ocean observing system is demonstrated herein by conducting two state estimation experiments, differing only in the use or not of seal data to constrain the system. Including seal-derived data substantially modifies the estimated surface mixedlayer properties and circulation patterns within and south of the Antarctic Circumpolar Current. Agreement with independent satellite observations of sea ice concentration is improved, especially along the East Antarctic shelf. Instrumented animals efficiently reduce a critical observational gap, and their contribution to monitoring polar climate variability will continue to grow as data accuracy and spatial coverage increase.
    Repository Name: EPIC Alfred Wegener Institut
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  • 18
    Publication Date: 2017-10-18
    Description: Efforts to extract a Greenland ice core with a complete record of the Eemian interglacial (130,000 to 115,000 years ago) have until now been unsuccessful. The response of the Greenland ice sheet to the warmer-than-present climate of the Eemian has thus remained unclear. Here we present the new North Greenland Eemian Ice Drilling (‘NEEM’) ice core and show only a modest ice-sheet response to the strong warming in the early Eemian. We reconstructed the Eemian record from folded ice using globally homogeneous parameters known from dated Greenland and Antarctic ice-core records. On the basis of water stable isotopes, NEEM surface temperatures after the onset of the Eemian (126,000 years ago) peaked at 8 ± 4 degrees Celsius above the mean of the past millennium, followed by a gradual cooling that was probably driven by the decreasing summer insolation. Between 128,000 and 122,000 years ago, the thickness of the northwest Greenland ice sheet decreased by 400 ± 250 metres, reaching surface elevations 122,000 years ago of 130 ± 300 metres lower than the present. Extensive surface melt occurred at the NEEM site during the Eemian, a phenomenon witnessed when melt layers formed again at NEEM during the exceptional heat of July 2012. With additional warming, surface melt might become more common in the future.
    Repository Name: EPIC Alfred Wegener Institut
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  • 19
    Publication Date: 2014-12-16
    Description: [1] The Antarctic Intermediate Water (AAIW) is a key player in global-scale oceanic overturning processes and an important conduit for heat, fresh water, and carbon transport. The AAIW past variability is poorly understood mainly due to the lack of sedimentary archives at intermediate water depths. We present records of benthic stable isotopes from sediments retrieved with the seafloor drill rig MARUM-MeBo at 956 m water depth off northern Chile (GeoB15016, 27°29.48′S, 71°07.58′W) that extend back to 970 ka. The sediments at this site are presently deposited at the boundary between AAIW and Pacific Deep Water (PDW). For previous peak interglacials, our results reveal similar benthic δ13C values at site GeoB15016 and of a newly generated stack of benthic δ13C from various deep Pacific cores representing the “average PDW.” This suggests, unlike today, the absence of AAIW at the site and the presence of nearly pure PDW. In contrast, more positive δ13C values at site GeoB15016 compared to the stack imply a considerable AAIW contribution during cold phases of interglacials and especially during glacials. Besides, we used three short sediment cores to reconstruct benthic δ13C values from the AAIW core during the last glacial and found a δ13C signature similar to today's. Assuming that this was the case also for the past 970 kyr, we demonstrate that sea level changes and latitudinal migrations of the AAIW formation site can only account for about 50% of the full range of past δ13C increases at site GeoB15016 during cold periods. Other processes that could explain the remaining of the positive δ13C anomalies are increases in glacial AAIW production and/or deeper convection of the AAIW with respect to preceding interglacials.
    Repository Name: EPIC Alfred Wegener Institut
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  • 20
    Publication Date: 2014-06-25
    Description: wo commonly used proxies based on the distribution of glycerol dialkyl glycerol tetraethers (GDGTs) are the TEX86 (TetraEther indeX of 86 carbon atoms) paleothermometer for sea surface temperature reconstructions and the BIT (Branched Isoprenoid Tetraether) index for reconstructing soil organic matter input to the ocean. An initial round-robin study of two sediment extracts, in which 15 laboratories participated, showed relatively consistent TEX86 values (reproducibility ±3–4°C when translated to temperature) but a large spread in BIT measurements (reproducibility ±0.41 on a scale of 0–1). Here we report results of a second round-robin study with 35 laboratories in which three sediments, one sediment extract, and two mixtures of pure, isolated GDGTs were analyzed. The results for TEX86 and BIT index showed improvement compared to the previous round-robin study. The reproducibility, indicating interlaboratory variation, of TEX86 values ranged from 1.3 to 3.0°C when translated to temperature. These results are similar to those of other temperature proxies used in paleoceanography. Comparison of the results obtained from one of the three sediments showed that TEX86 and BIT indices are not significantly affected by interlaboratory differences in sediment extraction techniques. BIT values of the sediments and extracts were at the extremes of the index with values close to 0 or 1, and showed good reproducibility (ranging from 0.013 to 0.042). However, the measured BIT values for the two GDGT mixtures, with known molar ratios of crenarchaeol and branched GDGTs, had intermediate BIT values and showed poor reproducibility and a large overestimation of the “true” (i.e., molar-based) BIT index. The latter is likely due to, among other factors, the higher mass spectrometric response of branched GDGTs compared to crenarchaeol, which also varies among mass spectrometers. Correction for this different mass spectrometric response showed a considerable improvement in the reproducibility of BIT index measurements among laboratories, as well as a substantially improved estimation of molar-based BIT values. This suggests that standard mixtures should be used in order to obtain consistent, and molar-based, BIT values.
    Repository Name: EPIC Alfred Wegener Institut
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  • 21
    Publication Date: 2019-07-16
    Description: Estimates of the relative motion between the Hawaiian and Louisville hot spots have consequences for understanding the role and character of deep Pacific-mantle return flow. The relative motion between these primary hot spots can be inferred by comparing the age records for their seamount trails. We report 40Ar/39Ar ages for 18 lavas from 10 seamounts along the Hawaiian-Emperor Seamount Chain (HESC), showing that volcanism started in the sharp portion of the Hawaiian-Emperor Bend (HEB) at ≥47.5 Ma and continued for ≥5 Myr. The slope of the along-track distance from the currently active Hawaiian hot spot plotted versus age is constant (57 ± 2 km/Myr) between ∼57 and 25 Ma in the central ∼1900 km of the seamount chain, including the HEB. This model predicts an age for the oldest Emperor Seamounts that matches published ages, implying that a linear age-distance relationship might extend back to at least 82 Ma. In contrast, Hawaiian age progression was much faster since at least ∼15 Ma and possibly as early as ∼27 Ma. Linear age-distance relations for the Hawaii-Emperor and Louisville seamount chains predict ∼300 km overall hot spot relative motion between 80 and 47.5 Ma, in broad agreement with numerical models of plumes in a convecting mantle, and paleomagnetic data. We show that a change in hot spot relative motion may also have occurred between ∼55 Ma and ∼50 Ma. We interpret this change in hot spot motion as evidence that the HEB reflects a combination of hot spot and plate motion changes driven by the same plate/mantle reorganization.
    Repository Name: EPIC Alfred Wegener Institut
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  • 22
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    Wiley
    In:  EPIC3Geophysical Research Letters, Wiley, 40(21), pp. 5735-5739, ISSN: 0094-8276
    Publication Date: 2019-07-16
    Description: The western Ross Sea is one of the key sites for cross-shelf water exchange around Antarctica. The mech- anism through which tides affect the cross-shelf exchange in the northwestern Ross Sea is investigated using numeri- cal simulations. Tides are found to increase the high-salinity shelf water (HSSW) outflow through the impact on the warm water intrusion of open ocean origin. The residual tidal currents are onshore along the Modified Circumpolar Deep Water pathway and therefore enhance its intrusion. Lighter ambient water adjacent to the HSSW increases the cross-flow density gradient, thus strengthening the HSSW export. At the same time, the onshore residual current and increased dilution of the HSSW have the potential to reduce the export rate. Owing to the existence of opposite tidal effects, the strongest HSSW export happens at the inter- mediate tidal forcing strength. The amplification of tides on cross-shelf exchange indicates that the relevant dynam- ical processes should be simulated or parameterized in climate models in order to adequately predict the ocean.
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  • 23
    Publication Date: 2019-07-17
    Description: We present a climatology of the diurnal variation of short-lived atmospheric compounds, such as ClO, BrO, HO2, and HOCl, as well as longer-lived species: O3, the hydrogen chloride isotopes H35Cl and H37Cl, and HNO3. Measurements were taken by the Superconducting Submillimeter-wave Limb-Emission Sounder (SMILES). This spectrally resolving radiometer, with very low observation noise and altitude range from the lower stratosphere to the lower thermosphere (20–100km), was measuring vertical profiles of absorption spectra along a non-sun-synchronous orbit, thus observing at all local times. We used the retrieved volume mixing ratio profiles to compile climatologies that are a function of pressure, a horizontal coordinate (latitude or equivalent latitude), and a temporal coordinate (solar zenith angle or local solar time). The main product presented are climatologies with a high resolution of the temporal coordinate (diurnal variation climatologies). In addition, we provide climatologies with a high resolution of the horizontal coordinate (zonal climatologies).The diurnal variation climatologies are based on data periods of 2 months and the zonal climatologies on monthly data periods. Consideration of the SMILES time-space sampling patterns with respect to the averaging coordinates is a key issue for climatology creation, especially in case of diurnal variation climatologies. Biases induced by inhomogeneous sampling are minimized by carefully choosing the size of averaging bins. The sampling biases of the diurnal variation climatology of ClO and BrO are investigated in a comparison of homogeneously sampled model data versus SMILES-sampled model data from the stratospheric Lagrangian chemistry and transport model ATLAS. In most cases, the relative sampling error is in the range of 0–20%. The strongest impact of sampling biases is found where the species' temporal gradients are strongest (mostly at sunrise and sunset), with a relative error of 60–100%. The SMILES climatology data sets are available via the SMILES data distribution home page.
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  • 24
    Publication Date: 2014-11-28
    Description: We explore the impact of a latitudinal shift in the westerly wind belt over the Southern Ocean on the Atlantic meridional overturning circulation (AMOC) and on the carbon cycle for Last Glacial Maximum background conditions using a state-of-the-art ocean general circulation model. We find that a southward (northward) shift in the westerly winds leads to an intensification (weakening) of no more than 10% of the AMOC. This response of the ocean physics to shifting winds agrees with other studies starting from pre-industrial background climate, but the responsible processes are different. In our setup changes in AMOC seemed to be more pulled by upwelling in the south than pushed by down-welling in the north, opposite to what previous studies with different background climate are suggesting. The net effects of the changes in ocean circulation lead to a rise in atmospheric pCO2 of less than 10 μatm for both a northward and a southward shift in the winds. For northward shifted winds the zone of upwelling of carbon and nutrient rich waters in the Southern Ocean is expanded, leading to more CO2 out-gassing to the atmosphere but also to an enhanced biological pump in the subpolar region. For southward shifted winds the upwelling region contracts around Antarctica leading to less nutrient export northwards and thus a weakening of the biological pump. These model results do not support the idea that shifts in the westerly wind belt play a dominant role in coupling atmospheric CO2 rise and Antarctic temperature during deglaciation suggested by the ice core data.
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    Wiley
    In:  EPIC3Journal of Geophysical Research: Atmospheres, Wiley, 118(14), pp. 7698-7714, ISSN: 2169-8996
    Publication Date: 2014-06-06
    Description: The coupled regional climate model HIRHAM-NAOSIM is used to investigate feedbacks between September sea ice anomalies in the Arctic and atmospheric conditions in autumn and the subsequent winter. A six-member ensemble of simulations spanning the period 1949–2008 is analyzed. The results show that negative Arctic sea ice anomalies are associated with increased heat and moisture fluxes, decreased static stability, increased lower tropospheric moisture, and modified baroclinicity, synoptic activity, and atmospheric large-scale circulation. The circulation changes in the following winter display meridionalized flow but are not fully characteristic of a negative Arctic Oscillation pattern, though they do support cold winter temperatures in northern Eurasia. Internally generated climate variability causes significant uncertainty in the simulated circulation changes due to sea ice-atmosphere interactions. The simulated atmospheric feedback patterns depend strongly on the position and strength of the regional sea ice anomalies and on the analyzed time period. The strongest atmospheric feedbacks are related to sea ice anomalies in the Beaufort Sea. This work suggests that there are complex feedback mechanisms that support a statistical link between reduced September sea ice and Arctic winter circulation. However, the feedbacks depend on regional and decadal variations in the coupled atmosphere-ocean-sea ice system.
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  • 26
    Publication Date: 2017-06-27
    Description: Paleoceanographic archives derived from 17 marine sediment cores reconstruct the response of the Southwest Pacific Ocean to the peak interglacial, Marine Isotope Stage (MIS) 5e (ca. 125 ka). Paleo-Sea Surface Temperature (SST) estimates were obtained from the Random Forest model—an ensemble decision tree tool—applied to core-top planktonic foraminiferal faunas calibrated to modern SSTs. The reconstructed geographic pattern of the SST anomaly (maximum SST between 120 and 132 ka minus mean modern SST) seems to indicate how MIS 5e conditions were generally warmer in the Southwest Pacific, especially in the western Tasman Sea where a strengthened East Australian Current (EAC) likely extended subtropical influence to ca. 45°S off Tasmania. In contrast, the eastern Tasman Sea may have had a modest cooling except around 45°S. The observed pattern resembles that developing under the present warming trend in the region. An increase in wind stress curl over the modern South Pacific is hypothesized to have spun-up the South Pacific Subtropical Gyre, with concurrent increase in subtropical flow in the western boundary currents that include the EAC. However, warmer temperatures along the Subtropical Front and Campbell Plateau to the south suggest that the relative influence of the boundary inflows to eastern New Zealand may have differed in MIS 5e, and these currents may have followed different paths compared to today.
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    In:  EPIC3Journal of Geophysical Research-Earth Surface, Wiley, 118(2), pp. 693-705, ISSN: 0148-0227
    Publication Date: 2017-05-29
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    Publication Date: 2022-05-25
    Description: © Macmillan Publishers Limited, 2010. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. The definitive version was published in Nature Communications 1 (2010): 49, doi:10.1038/ncomms1045.
    Description: Motor innervation to the tetrapod forelimb and fish pectoral fin is assumed to share a conserved spinal cord origin, despite major structural and functional innovations of the appendage during the vertebrate water-to-land transition. In this paper, we present anatomical and embryological evidence showing that pectoral motoneurons also originate in the hindbrain among ray-finned fish. New and previous data for lobe-finned fish, a group that includes tetrapods, and more basal cartilaginous fish showed pectoral innervation that was consistent with a hindbrain-spinal origin of motoneurons. Together, these findings support a hindbrain–spinal phenotype as the ancestral vertebrate condition that originated as a postural adaptation for pectoral control of head orientation. A phylogenetic analysis indicated that Hox gene modules were shared in fish and tetrapod pectoral systems. We propose that evolutionary shifts in Hox gene expression along the body axis provided a transcriptional mechanism allowing eventual decoupling of pectoral motoneurons from the hindbrain much like their target appendage gained independence from the head.
    Description: Th is work was supported by the National Institutes of Health and National Science Foundation.
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 3 (2013): 2802, doi:10.1038/srep02802.
    Description: It is usually assumed that metabolic constraints restrict deep-sea corals to cold-water habitats, with ‘deep-sea’ and ‘cold-water’ corals often used as synonymous. Here we report on the first measurements of biological characters of deep-sea corals from the central Red Sea, where they occur at temperatures exceeding 20°C in highly oligotrophic and oxygen-limited waters. Low respiration rates, low calcification rates, and minimized tissue cover indicate that a reduced metabolism is one of the key adaptations to prevailing environmental conditions. We investigated four sites and encountered six species of which at least two appear to be undescribed. One species is previously reported from the Red Sea but occurs in deep cold waters outside the Red Sea raising interesting questions about presumed environmental constraints for other deep-sea corals. Our findings suggest that the present understanding of deep-sea coral persistence and resilience needs to be revisited.
    Keywords: Ecosystem ecology ; Biodiversity ; Genetics ; Metabolism
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 496 (2013): 311-316, doi:10.1038/nature12027.
    Description: The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution.
    Description: cquisition and storage of Latimeria chalumnae samples was supported by grants from the African Coelacanth Ecosystem Programme of the South African National Department of Science and Technology. Generation of the Latimeria chalumnae and Protopterus annectens sequences by the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University was supported by grants from the National Human Genome Research Institute (NHGRI). K.L.T. is the recipient of a EURYI award from the European Science Foundation.
    Keywords: Genome evolution ; Comparative genomics
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 499 (2013): 209–213, doi:10.1038/nature12221.
    Description: Coccolithophores have influenced the global climate for over 200 million years1. These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems2. They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space3. Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean4. Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
    Description: Joint Genome Institute (JGI) contributions were supported by the Office of Science of the US Department of Energy (DOE) under contract no. 7DE-AC02-05CH11231.
    Keywords: Genetic variation
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 499 (2013): 431–437, doi:10.1038/nature12352.
    Description: Genome sequencing enhances our understanding of the biological world by providing blueprints for the evolutionary and functional diversity that shapes the biosphere. However, microbial genomes that are currently available are of limited phylogenetic breadth, owing to our historical inability to cultivate most microorganisms in the laboratory. We apply single-cell genomics to target and sequence 201 uncultivated archaeal and bacterial cells from nine diverse habitats belonging to 29 major mostly uncharted branches of the tree of life, so-called ‘microbial dark matter’. With this additional genomic information, we are able to resolve many intra- and inter-phylum-level relationships and to propose two new superphyla. We uncover unexpected metabolic features that extend our understanding of biology and challenge established boundaries between the three domains of life. These include a novel amino acid use for the opal stop codon, an archaeal-type purine synthesis in Bacteria and complete sigma factors in Archaea similar to those in Bacteria. The single-cell genomes also served to phylogenetically anchor up to 20% of metagenomic reads in some habitats, facilitating organism-level interpretation of ecosystem function. This study greatly expands the genomic representation of the tree of life and provides a systematic step towards a better understanding of biological evolution on our planet.
    Description: The work conducted by the US Department of Energy Joint Genome Institute is supported by the Office of Science of the US Department of Energy under Contract No. DE-AC02-05CH11231. We also thank the CeBiTec Bioinformatics Resource Facility, which is supported byBMBF grant 031A190. B.P.H. and J.A.D. were supported by the NASA Exobiology grant EXO-NNX11AR78GandNSFOISE 096842and B.P.H. by a generous contribution from G. Fullmer through the UNLV Foundation. S.M.S was supported by NSF grants OCE-0452333 and OCE-1136727, and the WHOI’s Andrew W. Mellon Fund for Innovative Research; and S.J.H. by the Canadian Foundation for Innovation, the British Columbia Knowledge Development Fund, the National Sciences and Engineering Research Council (NSERC) of Canada and the TULA foundation funded Centre for Microbial Diversity and Evolution (CMDE), and the Canadian Institute for Advanced Research (CIFAR). R.S. was supported by NSF grants DEB-841933, EF-826924, OCE-1232982, OCE-821374 and OCE-1136488, and the Deep Life I grant by the Alfred P. Sloan Foundation. P.H.was supported by a Discovery Outstanding Researcher Award (DORA) from the Australian Research Council, grant DP120103498.
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    Publication Date: 2022-05-26
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature 500 (2013): 453–457, doi:10.1038/nature12326.
    Description: Loss of sexual reproduction is considered an evolutionary dead end for metazoans, but bdelloid rotifers challenge this view as they appear to have persisted asexually for millions of years1. Neither male sex organs nor meiosis have ever been observed in these microscopic animals: oocytes are formed through mitotic divisions, with no reduction of chromosome number and no indication of chromosome pairing2. However, current evidence does not exclude that they may engage in sex on rare, cryptic occasions. Here we report the genome of a bdelloid rotifer, Adineta vaga (Davis, 1873)3, and show that its structure is incompatible with conventional meiosis. At gene scale, the genome of A. vaga is tetraploid and comprises both anciently duplicated segments and less divergent allelic regions. However, in contrast to sexual species, the allelic regions are rearranged and sometimes even found on the same chromosome. Such structure does not allow meiotic pairing; instead, we find abundant evidence of gene conversion, which may limit the accumulation of deleterious mutations in the absence of meiosis. Gene families involved in resistance to oxidation, carbohydrate metabolism and defence against transposons are significantly expanded, which may explain why transposable elements cover only 3% of the assembled sequence. Furthermore, 8% of the genes are likely to be of non-metazoan origin and were probably acquired horizontally. This apparent convergence between bdelloids and prokaryotes sheds new light on the evolutionary significance of sex.
    Description: This work was supported by Genoscope-CES (where most of the sequencing was performed), by US National Science Foundation grants MCB-0821956 and MCB-1121334 to I.A., by German Research Foundation grant HA 5163/2-1 to O.H., by grant 11.G34.31.0008 fromthe Ministry of Education and Science of the Russian Federation to A.S.K., by grant NSF CAREER number 0644282 to M.K., by US National Science Foundation grant MCB-0923676 to D.B.M.W., by FRFC grant 2.4.655.09.F from the Belgian Fonds National de la Recherche Scientifique (FNRS) and a start-up grant from the University of Namur to K.V.D.; J.F.F. and K.V.D. thank also J.-P. Descy (University of Namur) for funding support.
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    Publication Date: 2022-05-26
    Description: © Macmillan Publishers, 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Oncogene 32 (2013): 1135–1143, doi:10.1038/onc.2012.135.
    Description: Neurofibromatosis type 2 patients develop schwannomas, meningiomas and ependymomas resulting from mutations in the tumor suppressor gene, NF2, encoding a membrane-cytoskeleton adapter protein called merlin. Merlin regulates contact inhibition of growth and controls the availability of growth factor receptors at the cell surface. We tested if microtubule-based vesicular trafficking might be a mechanism by which merlin acts. We found that schwannoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases, had decreased intracellular vesicular trafficking relative to normal human Schwann cells. In Nf2−/− mouse Schwann (SC4) cells, re-expression of merlin as well as inhibition of Rac or its effector kinases, MLK and p38SAPK, each increased the velocity of Rab6 positive exocytic vesicles. Conversely, an activated Rac mutant decreased Rab6 vesicle velocity. Vesicle motility assays in isolated squid axoplasm further demonstrated that both mutant merlin and active Rac specifically reduce anterograde microtubule-based transport of vesicles dependent upon the activity of p38SAPK kinase. Taken together, our data suggest loss of merlin results in the Rac-dependent decrease of anterograde trafficking of exocytic vesicles, representing a possible mechanism controlling the concentration of growth factor receptors at the cell surface.
    Description: This work was supported by NIH R01 CA118032 (to NR), and MBL research fellowships (to NR and GM), NIH R01 NS23868 (to STB).
    Keywords: Merlin ; NF2 ; Rac ; Trafficking ; Exocytosis
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    Nature biotechnology 24 (2006), S. 1048-1049 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 200% ethanol boost from Oz sugar University of Queensland (UQ), Australia, molecular geneticist Robert Birch got more than he bargained for when he introduced a bacterial gene into sugarcane to convert sucrose into its high-value isomer, isomaltulose. In fact, the gene encoding sucrose isomerase, ...
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    Nature biotechnology 24 (2006), S. 1484-1485 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Common bacteria, engineered to safely seek out and kill tumors, may well be the next generation of cancer therapeutics. In this issue, Bettegowda et al. report the genome sequence of one such bacterium, Clostridium novyi-NT, which has been engineered to be non-toxic by deleting the major systemic ...
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    Nature biotechnology 24 (2006), S. 1491-1493 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This June, Basel-based Novartis Pharmaceuticals made a first reconnoiter into antimicrobial antibodies in its quest to find new weapons to fight infections. It paid $569 million to acquire NeuTec Pharmaceuticals of Manchester, UK, and its two late-stage products, both antibody fragments ...
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    Nature biotechnology 24 (2006), S. 1504-1507 
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    Notes: [Auszug] The scarcity of disease in wild plants indicates that the success of plant defense mechanisms in combating pathogen infection rivals that of mammalian immune systems. Although there are some interesting parallels between plant and animal defense strategies—for instance, both groups sacrifice ...
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    Nature biotechnology 24 (2006), S. 1515-1519 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Food and Drug Administration (FDA) has recently rejected new antibiotics for common infections citing the requirement that the drugs intended to treat non-serious infections prove superior to placebo rather than active controls. With the introduction of more stringent statistical criteria, ...
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    Nature biotechnology 24 (2006), S. 1521-1528 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For developers of antibacterial products, this century began very much on the wrong foot. The number of pharmaceutical companies chasing antibiotics continued to drop, few genuinely new antibiotics reached the clinic and investors remained lukewarm toward startups in this sector. But, despite ...
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    Nature biotechnology 24 (2006), S. 1565-1567 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A support vector machine (SVM) is a computer algorithm that learns by example to assign labels to objects. For instance, an SVM can learn to recognize fraudulent credit card activity by examining hundreds or thousands of fraudulent and nonfraudulent credit card activity reports. Alternatively, an ...
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    ISSN: 1546-1696
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    Notes: [Auszug] Bacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb ...
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    Nature biotechnology 24 (2006), S. 1569-1571 
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    Notes: [Auszug] The utility of blue fluorescent protein (BFP) has been limited by its low quantum yield and rapid photobleaching. A library targeting residues neighboring the chromophore yielded a variant with enhanced quantum yield (0.55 versus 0.34), reduced pH sensitivity and a 40-fold increase in ...
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    Nature biotechnology 24 (2006), S. 1551-1557 
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    Notes: [Auszug] Short cationic amphiphilic peptides with antimicrobial and/or immunomodulatory activities are present in virtually every life form, as an important component of (innate) immune defenses. These host-defense peptides provide a template for two separate classes of antimicrobial drugs. Direct-acting ...
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    Nature biotechnology 24 (2006), S. 1300-1300 
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    Notes: [Auszug] Is it possible that ImClone didn't do its homework on Erbitux's ...
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    Nature biotechnology 24 (2006), S. 1303-1303 
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    Notes: [Auszug] On the average report card a test score of three out of five would usually draw the comment 'could do better'. The admonishment to try harder was also given by some observers to Darmstadt-based Merck KGaA's surprise €10.6- ($13.2)-billion acquisition of Serono on September 21. Although ...
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    Nature biotechnology 24 (2006), S. 1081-1081 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotech stocks can be white-knuckle volatile, but there is a way you can profit from, or insure against, such rapid and dramatic price changes. Through put and call options, you may not only make more profits, but also buy and sell 'protection' for your investments (with no need for 'knuckle' ...
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    Nature biotechnology 24 (2006), S. 1095-1095 
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    Notes: [Auszug] Recent patent applications in tissue engineering ...
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    Nature biotechnology 24 (2006), S. 1091-1094 
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    Notes: [Auszug] Gene patenting has attracted intense scrutiny for decades, raising a host of ethical, legal and economic concerns. Much of the policy debate has focused on seemingly quantifiable and practical concerns about the effect of patents on access to useful technologies in the contexts of both research and ...
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    Nature biotechnology 24 (2006), S. 1322-1323 
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    Notes: [Auszug] To the editor: One of the challenges for the future is how to integrate all the DNA microarray data that have been generated and deposited in public databases. We have studied data from two data repositories and identified that only 38% meet necessary quality and data format standards. Our results ...
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    Nature biotechnology 24 (2006), S. 1097-1098 
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    Notes: [Auszug] Of the many differentiated cell types that have been derived in vitro from mouse embryonic stem (ES) cells, among the most intriguing are cells resembling male and female gametes. Such ES cell–derived germ cells have been shown to undergo meiosis to form haploid gametes that can support early ...
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    Nature biotechnology 24 (2006), S. 1352-1354 
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    Notes: [Auszug] The increasingly commercial nature of biomedical research is, rightly or not, a reality of the contemporary research environment. The percentage of biomedical research supported by industry continues to grow, and many public funding agencies now encourage industry partnerships. Although links with ...
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    Nature biotechnology 24 (2006), S. 1359-1361 
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    Notes: [Auszug] Plant-derived 'essential oils' such as terpenoids are widely used in the fragrance and flavor industries. In this issue, Chappell and colleagues describe an approach for engineering plants that produce elevated levels of commercially relevant terpenoids. They co-express both an enzyme that supplies ...
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    Nature biotechnology 24 (2006), S. 1365-1366 
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    Notes: [Auszug] The rallying cry of early 21st century biomedical science is that new combinations of genomic, proteomic and bioinformatic research will provide deeper insights into disease mechanisms, novel markers for diagnostics and new molecular targets for therapeutic intervention. DNA and protein microarrays ...
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    Nature biotechnology 24 (2006), S. 1374-1376 
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    Notes: [Auszug] Trying to make some sense of it all, But I can see that it makes no sense at all, Is it cool to go to sleep on the floor, 'Cause I don't think that I can take anymore Clowns to the left of me, jokers to the right, Here I am, stuck in the middle with you. Joe Egan and Gerry Rafferty There are ...
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    Nature biotechnology 24 (2006), S. 1448-1448 
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    Notes: [Auszug] Nat. Biotechnol. 24, 397–400 (2006); published online 29 March 2006; corrected after print 8 November 2006. In the version of this article initially published, on page 399, column 2, paragraph 4, the authors wrongly credited the idea for using cells from nonviable human embryos as an ...
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    Notes: [Auszug] Transcription factors (TFs) interact with specific DNA regulatory sequences to control gene expression throughout myriad cellular processes. However, the DNA binding specificities of only a small fraction of TFs are sufficiently characterized to predict the sequences that they can and cannot bind. ...
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    Notes: [Auszug] Severe acute liver failure, even when transient, must be treated by transplantation and lifelong immune suppression. Treatment could be improved by bioartificial liver (BAL) support, but this approach is hindered by a shortage of human hepatocytes. To generate an alternative source of cells for BAL ...
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    Nature biotechnology 24 (2006), S. 1377-1383 
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    Notes: [Auszug] The recent influenza vaccine shortages have provided a timely reminder of the tenuous nature of the world's vaccine supply and the potential for manufacturing issues to severely disrupt vital access to important vaccines. The application of new technologies to the discovery, assessment, development ...
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    Nature biotechnology 24 (2006), S. 1039-1039 
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    Notes: [Auszug] No technology embodies the rise of 'omic' science more than the DNA microarray. First reduced to practice in the early 1990s, it has since undergone numerous iterations, adaptations and refinements to achieve its present status as the platform of choice for massively parallel gene expression ...
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    Nature biotechnology 24 (2006), S. 1184-1184 
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    Notes: [Auszug] One year on from the enforcement of Brazil's innovation law, the first national innovation law in Latin America, it has already earned praise from the country's scientific community, especially from that part dealing with applied research in industry and agriculture, with an emphasis on biotech. ...
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    Nature biotechnology 24 (2006), S. 1188-1188 
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    Notes: [Auszug] When Michael Fernandez took over as director of the Pew Initiative on Food and Biotechnology (PIFB) in September 2005, his former boss bequeathed to him a lava lamp for his desk. Oddly enough, the lamp had been the prize for a Halloween costume that parodied Fernandez' image as a dapper science ...
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    Nature biotechnology 24 (2006), S. 1199-1200 
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    Notes: [Auszug] To the editor: In their letter of correspondence “Eprex-associated pure red cell aplasia and leachates” in the June issue (Nat. Biotechnol. 24, 613–614, 2006), Schellekens & Jiskoot discuss what they consider to be flaws in Johnson & Johnson's (J&J; New Brunswick, NJ, ...
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    Nature biotechnology 24 (2006), S. 1207-1207 
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    Notes: [Auszug] When a biotech company succeeds, it can find more cash in the bank than needed for research and development. It may decide to buy back, or repurchase, its own shares. A buyback is neither good nor bad by definition, but may be smart, dumb or bordering on fraudulent. To make you a savvier, more ...
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    Nature biotechnology 24 (2006), S. 1474-1475 
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    Notes: [Auszug] To the editor: Determining the functions of genes and proteins is a central problem in biology, fundamental to understanding the molecular and biochemical processes that sustain health or cause disease, to identifying and validating new drug targets and to developing reliable diagnostics. Recent ...
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    Nature biotechnology 24 (2006), S. 1223-1224 
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    Notes: [Auszug] The emergence of systems biology has led to a demand for quantitative, comprehensive data on all aspects of biological phenomena. Some aspects, such as RNA expression and protein structure, have received much attention, while others, such as protein location, have lagged behind. In this issue, ...
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    Nature biotechnology 24 (2006), S. 1227-1229 
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    Notes: [Auszug] The shift toward sustainable production systems has focused attention on bioplastics, which can be produced by many microorganisms from renewable raw materials. Polyhydroxyalkanoates (PHAs) are natural polyesters synthesized in the form of discrete intracellular granules in abundances that can ...
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    Nature biotechnology 24 (2006), S. 1229-1230 
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    Notes: [Auszug] Wastewater treatment around the world relies largely on microbial ecosystems, yet little is known about the organisms involved. This 'black box' system mediates aerobic and anaerobic processes that diminish high phosphate loads in wastewaters, a process known as enhanced biological phosphate ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 24, 841–847 (2006); published online 25 June 2006; corrected after print 25 July 2006 In the print version of this article and the version initially published online, the last sentence of the URLs section in Methods, p.846, reads, “Sequence information regarding the ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 23, 995–1001 (2005), published online 17 July 2005; corrected after print 25 July 2006 In the Methods section, p. 1,000, col. 2, paragraph 2, the text beginning: “The whole plate was discarded if for any time point...” and ending, “The final data set ...
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    Nature biotechnology 24 (2006), S. 1033-1033 
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    Notes: [Auszug] Nat. Biotechnol. 24, 708–712 (2006); published online 21 May 2006; corrected after print 25 July 2006 In the Methods section, p.711, “Library construction and selection,” line 11 of the print version of this article and the version initially published online, the plates used for ...
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    Nature biotechnology 24 (2006), S. 51-53 
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    Notes: [Auszug] How does one model a simple cell-signaling pathway? Consider a simple example consisting of a stimulant, an extracellular signal, an inhibitor of the signal, a G protein–coupled receptor, a G protein and the cellular response. The stimulant induces production of the extracellular signal in ...
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    Nature biotechnology 24 (2006), S. 79-88 
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    Notes: [Auszug] Existing variants of green fluorescent protein (GFP) often misfold when expressed as fusions with other proteins. We have generated a robustly folded version of GFP, called 'superfolder' GFP, that folds well even when fused to poorly folded polypeptides. Compared to 'folding reporter' GFP, a ...
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    Nature biotechnology 24 (2006), S. 100-104 
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    Notes: [Auszug] Bacterial protein secretion is important in the life cycles of most bacteria, in which it contributes to the formation of pili and flagella and makes available extracellular enzymes to digest polymers for nutritional purposes and toxins to kill host cells in infections of humans, animals and ...
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    Nature biotechnology 24 (2006), S. 63-71 
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    Notes: [Auszug] The area devoted to growing transgenic plants expressing insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) is increasing worldwide. A major concern with the adoption of Bt crops is their potential impact on nontarget organisms including biological control organisms. Regulatory ...
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    Nature biotechnology 24 (2006), S. 874-874 
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    Notes: [Auszug] The return of the multiple sclerosis (MS) drug Tysabri (natalizumab) to the US market, sanctioned by the US Food and Drug Administration (FDA) on June 5, and its first-time approval in the EU, announced on June 29, was welcomed by investors. The move should also eventually lead to a clearer ...
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    Nature biotechnology 24 (2006), S. 875-876 
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    Notes: [Auszug] Nuvelo is forging ahead with phase 3 trials on its blood-clot buster enzyme alfimeprase, with results expected early next year. The recombinant enzyme attracted the attention of Bayer Healthcare, which earlier this year signed a $385-million deal for alfimeprase's non-US rights—an ...
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    Nature biotechnology 24 (2006), S. 884-884 
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    Notes: [Auszug] Diagnostics companies have had record fundraising on the public markets over the past few years. Venture capital also expanded last year, raising more than double than in previous years, with $113 million the average quarterly amount raised over the past year compared with only $47 ...
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    Nature biotechnology 24 (2006), S. 885-887 
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    Notes: [Auszug] Even as the science supporting innovation in drug and device development moves forward, the US agency charged with evaluating the products of that science remains embroiled in battles over resources and even its proper mandate. Indeed, the Food and Drug Administration (FDA, Rockville, MD, USA), ...
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    Nature biotechnology 24 (2006), S. 888-890 
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    Notes: [Auszug] Once the province of clinical genetics units in hospitals and clinics, genetic tests have become a commodity. With the click of a mouse, you can order up tests to find out whether you are a carrier of the cystic fibrosis (CF) gene, prone to cardiovascular disease or a member of an ancient tribe. ...
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    Nature biotechnology 24 (2006), S. 1226-1227 
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    Notes: [Auszug] Mass spectrometry (MS) allows the localization of phosphorylated amino acid residues in proteins. Precise annotation of phosphorylation sites is not trivial, however, because of the inherent complexity of most phosphopeptide mass spectra. In this issue, Beausoleil et al. report computational ...
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    Nature biotechnology 24 (2006), S. 899-899 
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    Notes: [Auszug] To the editor: In their commentary in the December issue (Nat. Biotechnol. 23, 1479–1480, 2005) Jon Beckwith and Franklin Huang chastise T. H. Morgan for his failure to make a fuss about eugenics in 1915. That year, he gave the Vanuxem Lectures at Princeton University, which were published ...
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    Nature biotechnology 24 (2006), S. 899-900 
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    Notes: [Auszug] To the editor: An endorsement of ethical responsibility in science is difficult to oppose. The challenge, however, often is to ascertain what constitutes an ethical or wise course of action. In their commentary, Beckwith and Huang allude specifically to a “stirring of the scientific ...
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    Nature biotechnology 24 (2006), S. 900-901 
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    Notes: [Auszug] To the editor: The letter by Katariina Majander et al. in last year's April issue (Nat. Biotechnol. 23, 475–481, 2005) described the use of a modified flagellar type III secretion system (TTSS) to secrete heterologous polypeptides into the growth medium of Escherichia coli. N-terminal ...
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    Nature biotechnology 24 (2006), S. 901-902 
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    Notes: [Auszug] Katariina Majander et al. respond In contrast to the comments of Gál et al., the aim of our paper was not to address the nature of the secretion signal motif per se but to evaluate the biotechnological potential of the secretion system. We did, however, briefly discuss the three proposed ...
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    Nature biotechnology 24 (2006), S. 914-916 
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    Notes: [Auszug] Chromogenic stains have been a mainstay as readouts for immunodiagnostics. 'Brown' staining—also known as diaminobenzidine (DAB) chromogenic staining or immunoperoxidase staining—was adopted very early in anatomic pathology and rapidly became the standard for immunohistochemistry in ...
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    Nature biotechnology 24 (2006), S. 902-903 
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    Notes: [Auszug] To the editor: PubMed is the key retrieval engine for Medline abstracts, and its host, the US National Library of Medicine (NLM; Bethesda, Maryland), provides efficient query interfaces. The result of queries is a list of abstracts, in which the most recent documents appear at the top. If the list ...
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    Nature biotechnology 24 (2006), S. 905-908 
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    Notes: [Auszug] Biomarkers measured in a variety of patient samples, including blood, tissue, urine and cerebrospinal fluid, are used in a diverse array of clinical settings. Although many successful biomarkers have been developed to date, advances in genetics and proteomics promise to usher in a new era of ...
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    Nature biotechnology 24 (2006), S. 927-929 
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    Notes: [Auszug] In vitro diagnostics (IVDs) has been an area of considerable innovation over the past decade, transforming the practice of medicine in the process. In the area of cardiovascular care alone, new markers for early cardiac injury and for heart failure have fundamentally changed the way doctors manage ...
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    Nature biotechnology 24 (2006), S. 930-930 
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    Notes: [Auszug] Although you might have been led to believe there is a 'clear vision' for the molecular diagnostics revolution, in reality the investing picture is much murkier. Revenues haven't produced much profit or free cash flow (and are unlikely to do so anytime soon). And rather than stand-alone diagnostics ...
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    Nature biotechnology 24 (2006), S. 45-46 
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    Notes: [Auszug] Fish have been used as models in cancer research for almost a century because of the strikingly similar histopathological features of fish and human tumors. Despite this agreement, however, very little is known about the correspondence of the molecular mechanisms that drive tumorigenesis in these ...
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    Nature biotechnology 24 (2006), S. 971-983 
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    Notes: [Auszug] Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted therapy and monitor activity and therapeutic response across a wide spectrum of disease. Proteomics methods based on mass spectrometry hold special promise for the discovery of novel biomarkers that might form ...
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    Nature biotechnology 24 (2006), S. 725-725 
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    Notes: [Auszug] The last time biofuels figured prominently on the editorial pages of this journal was July 1996. Back then, we were struck by how many biofuel projects appeared to be “solutions in search of a problem.” Ten years later, a problem has been found. Biofuels, in particular ethanol, are ...
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    Nature biotechnology 24 (2006), S. 727-728 
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    Notes: [Auszug] A flurry of investment activity during the first months of 2006 is evidence that some investors are waking up to the untapped market potential of a range of widely occurring gastrointestinal (GI) conditions that are as yet not well served. Companies, however, face difficult challenges because of ...
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 726-726 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] While biotech researchers are stepping up to increase the efficiency and reduce the environmental impact of ethanol production, investors are also doing their bit to get biofuel off the launch pad. No less than Bill Gates, entrepreneur Richard Branson, venture capital guru Vinod Khosla and ...
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  • 96
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 729-729 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Exelixis just presented phase 1 clinical trial data for three new kinase inhibitors at the 2006 American Society of Clinical Oncology annual meeting held in Atlanta, Georgia June 2–3. The compounds are included in a licensing and development deal with GlaxoSmithKline (GSK) that gives the ...
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  • 97
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 730-730 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In May, Merck, one of the oldest and stodgiest pharmaceutical companies, entered the biotech arena by announcing its plans to purchase two protein manufacturing firms: GlycoFi for $400 million and Abmaxis for $80 million. Now that even the most traditional pharmaceutical companies are ...
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  • 98
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 735-735 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Anyone who has spent time with Elliot Entis, CEO and cofounder of Aqua Bounty Technologies (ABT), has heard him say that he subscribes to the “pinball theory of life.” That is, when the right people and the right ideas are bouncing around together, the combination eventually results in ...
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 749-751 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In their Perspective on commercialized Bacillus thuringiensis (Bt) toxin transgenic crops and biological control in the January issue (Nat. Biotechnol. 24, 63–71, 2006), Jörg Romeis et al. draws some conclusions that do not fully and accurately represent the published ...
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    [s.l.] : Nature Publishing Group
    Nature biotechnology 24 (2006), S. 751-753 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Jörg Romeis, Michael Meissle and Franz Bigler respond: Our Perspective compiled available peer-reviewed literature addressing the impact on biological control organisms of transgenic crops that express Cry proteins derived from Bacillus thuringiensis (Bt). The published results were discussed ...
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