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  • 1
    Publication Date: 2022-05-25
    Description: The primary objective of this publication is to share with a wider audience the valuable information and extensive dialogue that took place amongst over 140 individuals who attended the second in a series of planned workshops on the science and management of coastal landforms in Massachusetts. This workshop took place at the Woods Hole Oceanographic Institution on January 24, 2001. The individuals who attended this workshop are actively engaged in planning, managing, regulating, engineering, educating, and studying coastal landforms and their beneficial functions. This workshop titled, Can Humans & Coastal Landforms Co-exist?’, was a natural follow-up to a previous workshop, Coastal Landform Management in Massachusetts, held at WHOI October 9-10, 1997 (proceedings published as WHOI Technical Report #WHOI-98-16). The workshop had a very practical, applied focus, providing state-of-the-art scientific understanding of coastal landform function, case history management and regulation of human activities proposed on coastal landforms, a multi-faceted mock conservation commission hearing presented by practicing technical consultants and attorneys that involved all attendees acting as regulators in breakout sessions, and, at the conclusion of the workshop, an open discussion on all issues related to the science and management of coastal landforms, including future research needs.
    Description: Funding for these proceedings was provided by WHOI Sea Grant and the NOAA National Sea Grant College Program Office, Department of Commerce, under NOAA Grant No. M10-2, Woods Hole Oceanographic Institution Sea Grant Project No. NA86R60075.
    Keywords: Coastal ; Landforms ; Humans
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
    Format: 1574993 bytes
    Format: application/pdf
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: Converging legal and scientific forces are pushing the traditional forensic identification sciences toward fundamental change. The assumption of discernible uniqueness that resides at the core of these fields is weakened by evidence of errors in proficiency testing and in actual cases. Changes in the law pertaining to the admissibility of expert evidence in court, together with the emergence of DNA typing as a model for a scientifically defensible approach to questions of shared identity, are driving the older forensic sciences toward a new scientific paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saks, Michael J -- Koehler, Jonathan J -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):892-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉College of Law, Arizona State University, Tempe, AZ 85287, USA. saks@asu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081727" target="_blank"〉PubMed〈/a〉
    Keywords: DNA/classification ; Expert Testimony ; Forecasting ; Forensic Sciences/legislation & jurisprudence/*trends ; Humans ; Models, Theoretical ; Reproducibility of Results
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohman, James C -- Lovejoy, C Owen -- White, Tim D -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):845; author reply 845.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15709231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Femoral Neck Fractures/pathology ; Femur/*anatomy & histology/radiography ; Femur Neck/anatomy & histology/radiography ; *Fossils ; Hominidae/*anatomy & histology/physiology ; Humans ; Locomotion ; Tomography, X-Ray Computed
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1550.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761133" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/anatomy & histology/*pathology ; Brain Diseases/*diagnosis ; *Diagnostic Imaging ; Humans ; *Incidental Findings ; *Research Subjects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1857.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790821" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Cell Line ; Cloning, Organism ; *Embryo Research/economics/legislation & jurisprudence ; Embryo, Mammalian/*cytology ; Humans ; *Research Support as Topic/legislation & jurisprudence ; *Stem Cells ; Tissue Donors/legislation & jurisprudence
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olson, Steve -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1548-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761132" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Brain/*anatomy & histology/*physiology ; Confidentiality ; Deception ; *Diagnostic Imaging ; Humans ; *Mental Processes ; *Personality ; *Privacy
    Print ISSN: 0036-8075
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: Dominance hierarchies occur in numerous social species, and rank within them can greatly influence the quality of life of an animal. In this review, I consider how rank can also influence physiology and health. I first consider whether it is high- or low-ranking animals that are most stressed in a dominance hierarchy; this turns out to vary as a function of the social organization in different species and populations. I then review how the stressful characteristics of social rank have adverse adrenocortical, cardiovascular, reproductive, immunological, and neurobiological consequences. Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sapolsky, Robert M -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):648-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305-5020, USA. sapolsky@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anxiety ; Behavior, Animal ; Cardiovascular Physiological Phenomena ; Catecholamines/metabolism ; Dominance-Subordination ; *Health Status ; Humans ; Hydrocortisone/metabolism ; Immune System/physiology ; Nervous System Physiological Phenomena ; *Primates/physiology/psychology ; Reproduction ; *Social Behavior ; Social Class ; *Social Dominance ; *Stress, Physiological/physiopathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2005-06-11
    Description: We show that inferences of competence based solely on facial appearance predicted the outcomes of U.S. congressional elections better than chance (e.g., 68.8% of the Senate races in 2004) and also were linearly related to the margin of victory. These inferences were specific to competence and occurred within a 1-second exposure to the faces of the candidates. The findings suggest that rapid, unreflective trait inferences can contribute to voting choices, which are widely assumed to be based primarily on rational and deliberative considerations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todorov, Alexander -- Mandisodza, Anesu N -- Goren, Amir -- Hall, Crystal C -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Princeton University, Princeton, NJ 08544, USA. atodorov@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15947187" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Character ; Decision Making ; *Face/anatomy & histology ; Federal Government ; Female ; Forecasting ; Humans ; Intelligence ; Judgment ; Leadership ; Male ; *Mental Competency ; *Politics ; *Social Perception ; Stereotyping ; Trust ; United States
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):43-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210515" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autophagy ; Brain-Derived Neurotrophic Factor/metabolism ; Cells, Cultured ; Clinical Trials as Topic ; Corpus Striatum/pathology ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Huntington Disease/*drug therapy/genetics/pathology/*physiopathology ; Mice ; Mitochondria/metabolism ; Mutation ; Nerve Tissue Proteins/chemistry/*genetics/metabolism/*physiology ; Neurons/*physiology ; Nuclear Proteins/chemistry/*genetics/metabolism/*physiology ; Peptides ; Transcription Factors/metabolism ; Trinucleotide Repeat Expansion
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2005-02-19
    Description: Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human cells the target of rapamycin (TOR) kinase and its associated protein rictor are necessary for Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector. The rictor-mTOR complex directly phosphorylated Akt/PKB on Ser473 in vitro and facilitated Thr308 phosphorylation by PDK1. Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sarbassov, D D -- Guertin, David A -- Ali, Siraj M -- Sabatini, David M -- R01 AI47389/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1098-101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718470" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Phosphoinositide-Dependent Protein Kinases ; Adaptor Proteins, Signal Transducing ; Animals ; Carrier Proteins/*metabolism ; Cell Line ; Cell Line, Tumor ; Drosophila Proteins/*metabolism ; Drosophila melanogaster ; Enzyme Activation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Immunoprecipitation ; Phosphatidylinositol 3-Kinases/*metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Protein-Serine-Threonine Kinases/*metabolism ; Proteins/metabolism ; Proto-Oncogene Proteins/*metabolism ; Proto-Oncogene Proteins c-akt ; RNA Interference ; Serine/metabolism ; TOR Serine-Threonine Kinases
    Print ISSN: 0036-8075
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1395.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933172" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bioterrorism/prevention & control ; Botulinum Toxins ; Food Supply ; Humans ; Milk ; *Periodicals as Topic ; Publishing ; *Retraction of Publication as Topic ; United States ; *United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
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  • 12
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1026.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718436" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; *Aging ; Bias (Epidemiology) ; Cohort Studies ; Confounding Factors (Epidemiology) ; Epidemiologic Methods ; Humans ; *Immunization Programs ; *Influenza Vaccines ; Influenza, Human/*mortality/*prevention & control ; United States/epidemiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: Funding bodies are coming to the aid of young scientists with a variety of programs aimed at helping them become independent investigators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Forde, Anne -- Pain, Elisabeth -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):427-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831761" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Mobility ; Education, Graduate ; *Faculty ; *Fellowships and Scholarships ; Great Britain ; Humans ; Ireland ; *Research Personnel ; *Research Support as Topic ; Universities
    Print ISSN: 0036-8075
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-08-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Aug 5;309(5736):864-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081709" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Alzheimer Disease/epidemiology/*prevention & control ; Animals ; Brain/physiology ; Education ; *Exercise ; Female ; Humans ; Life Style ; Male ; *Mental Processes
    Print ISSN: 0036-8075
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  • 15
    Publication Date: 2005-10-29
    Description: Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene expression. Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer. We identified recurrent gene fusions of the 5' untranslated region of TMPRSS2 to ERG or ETV1 in prostate cancer tissues with outlier expression. By using fluorescence in situ hybridization, we demonstrated that 23 of 29 prostate cancer samples harbor rearrangements in ERG or ETV1. Cell line experiments suggest that the androgen-responsive promoter elements of TMPRSS2 mediate the overexpression of ETS family members in prostate cancer. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomlins, Scott A -- Rhodes, Daniel R -- Perner, Sven -- Dhanasekaran, Saravana M -- Mehra, Rohit -- Sun, Xiao-Wei -- Varambally, Sooryanarayana -- Cao, Xuhong -- Tchinda, Joelle -- Kuefer, Rainer -- Lee, Charles -- Montie, James E -- Shah, Rajal B -- Pienta, Kenneth J -- Rubin, Mark A -- Chinnaiyan, Arul M -- 5P30 CA46592/CA/NCI NIH HHS/ -- P50CA69568/CA/NCI NIH HHS/ -- R01 CA97063/CA/NCI NIH HHS/ -- R01AG21404/AG/NIA NIH HHS/ -- UO1 CA111275-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):644-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109-0602, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254181" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/*genetics ; Gene Expression Regulation, Neoplastic ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Neoplasm Proteins/*genetics ; Oncogene Proteins, Fusion/*genetics ; Polymerase Chain Reaction ; Prostatic Neoplasms/*genetics ; Serine Endopeptidases/*genetics ; Trans-Activators/*genetics ; Transcription Factors/*genetics ; Translocation, Genetic
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  • 16
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kintisch, Eli -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1851.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790813" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Energy Metabolism ; Female ; Fraud ; History, 20th Century ; History, 21st Century ; Humans ; Menopause ; *National Institutes of Health (U.S.) ; *Publishing ; *Research Support as Topic ; Retraction of Publication as Topic ; *Scientific Misconduct ; United States
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawa, Akira -- Snyder, Solomon H -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1128-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. asawa1@jhmi.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293746" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/physiology ; Affective Disorders, Psychotic/enzymology/*genetics ; Carrier Proteins/physiology ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Humans ; Mutation ; Nerve Tissue Proteins/*genetics/physiology ; Protein Binding ; Schizophrenia/*genetics ; Signal Transduction ; Translocation, Genetic
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, Jon -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):23-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637239" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group/genetics ; Chemokines, CC/*genetics ; European Continental Ancestry Group/genetics ; *Gene Dosage ; Gene Duplication ; *Genetic Predisposition to Disease ; HIV Infections/*genetics ; Humans
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  • 19
    Publication Date: 2005-07-26
    Description: Land use has generally been considered a local environmental issue, but it is becoming a force of global importance. Worldwide changes to forests, farmlands, waterways, and air are being driven by the need to provide food, fiber, water, and shelter to more than six billion people. Global croplands, pastures, plantations, and urban areas have expanded in recent decades, accompanied by large increases in energy, water, and fertilizer consumption, along with considerable losses of biodiversity. Such changes in land use have enabled humans to appropriate an increasing share of the planet's resources, but they also potentially undermine the capacity of ecosystems to sustain food production, maintain freshwater and forest resources, regulate climate and air quality, and ameliorate infectious diseases. We face the challenge of managing trade-offs between immediate human needs and maintaining the capacity of the biosphere to provide goods and services in the long term.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foley, Jonathan A -- Defries, Ruth -- Asner, Gregory P -- Barford, Carol -- Bonan, Gordon -- Carpenter, Stephen R -- Chapin, F Stuart -- Coe, Michael T -- Daily, Gretchen C -- Gibbs, Holly K -- Helkowski, Joseph H -- Holloway, Tracey -- Howard, Erica A -- Kucharik, Christopher J -- Monfreda, Chad -- Patz, Jonathan A -- Prentice, I Colin -- Ramankutty, Navin -- Snyder, Peter K -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):570-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Sustainability and the Global Environment (SAGE), University of Wisconsin, 1710 University Avenue, Madison, WI 53726, USA. jfoley@wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040698" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Air Pollution ; Animals ; Animals, Wild ; Climate ; Communicable Diseases/epidemiology/transmission ; *Conservation of Natural Resources ; *Ecosystem ; *Environment ; Fresh Water ; Human Activities ; Humans ; Policy Making ; Trees
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, Jean -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):836-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705823" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Animals ; Cell Division ; Cell Nucleus/*metabolism ; Centromere/physiology ; Chromosome Segregation ; DNA Repair ; GTPase-Activating Proteins/metabolism ; Gene Expression Regulation ; Humans ; Molecular Chaperones ; Neurodegenerative Diseases/metabolism ; Nuclear Pore Complex Proteins/metabolism ; Proteins/*metabolism ; Small Ubiquitin-Related Modifier Proteins/chemistry/*physiology ; Spindle Apparatus/metabolism ; Transcription Factors/*metabolism ; Viral Proteins/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: Large numbers of noncoding RNA transcripts (ncRNAs) are being revealed by complementary DNA cloning and genome tiling array studies in animals. The big and as yet largely unanswered question is whether these transcripts are relevant. A paper by Willingham et al. shows the way forward by developing a strategy for large-scale functional screening of ncRNAs, involving small interfering RNA knockdowns in cell-based screens, which identified a previously unidentified ncRNA repressor of the transcription factor NFAT. It appears likely that ncRNAs constitute a critical hidden layer of gene regulation in complex organisms, the understanding of which requires new approaches in functional genomics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mattick, John S -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1527-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia. j.mattick@imb.uq.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141063" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Conserved Sequence ; DNA-Binding Proteins/antagonists & inhibitors ; *Genomics ; Humans ; Mice ; NFATC Transcription Factors ; Nuclear Proteins/antagonists & inhibitors ; *RNA Interference ; RNA, Untranslated/antagonists & inhibitors/genetics/*physiology ; Transcription Factors/antagonists & inhibitors ; beta Karyopherins/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1890-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373546" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Aspirin/therapeutic use ; Celecoxib ; Confounding Factors (Epidemiology) ; Cyclooxygenase 1 ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Cyclooxygenase Inhibitors/adverse effects/*therapeutic use ; Drug Interactions ; Heart Diseases/*drug therapy ; Humans ; Ibuprofen/therapeutic use ; Membrane Proteins/antagonists & inhibitors ; Naproxen/therapeutic use ; Pyrazoles/adverse effects/*therapeutic use ; Randomized Controlled Trials as Topic/ethics/methods/standards ; *Research Design ; Sulfonamides/adverse effects/*therapeutic use
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254155" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; Genomics ; *Haplotypes ; Humans
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    Publication Date: 2005-12-17
    Description: Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols). These domains are required for binding of poleta and poliota to ubiquitin, their accumulation in replication factories, and their interaction with monoubiquitinated PCNA. Moreover, the UBZ domain of poleta is essential to efficiently restore a normal response to ultraviolet irradiation in xeroderma pigmentosum variant (XP-V) fibroblasts. Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bienko, Marzena -- Green, Catherine M -- Crosetto, Nicola -- Rudolf, Fabian -- Zapart, Grzegorz -- Coull, Barry -- Kannouche, Patricia -- Wider, Gerhard -- Peter, Matthias -- Lehmann, Alan R -- Hofmann, Kay -- Dikic, Ivan -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1821-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biochemistry II, Goethe University Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357261" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Cell Line ; Computational Biology ; DNA/*biosynthesis ; *DNA Damage ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/*chemistry/genetics/*metabolism ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nuclear Magnetic Resonance, Biomolecular ; Point Mutation ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/metabolism ; Transfection ; Ubiquitin/*metabolism ; Xeroderma Pigmentosum/genetics ; Zinc Fingers
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1665.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16150988" target="_blank"〉PubMed〈/a〉
    Keywords: Breast/*anatomy & histology ; Breast Neoplasms/etiology ; Female ; Humans ; *Mammography ; Risk Factors ; *Software
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):684-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051760" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Blood Specimen Collection ; *Dna ; *Databases, Genetic ; Genetic Privacy ; Humans ; *Medical Records Systems, Computerized ; New York ; United States ; *United States Department of Veterans Affairs ; *Universities ; *Veterans
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):83.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994529" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Caloric Restriction ; Forecasting ; Humans ; Insulin-Like Growth Factor I/metabolism ; *Life Expectancy/trends ; *Longevity ; Oxidative Stress
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kone-Cni, Vladimir J -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793900" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; *Prisoners ; *Psychology, Social ; *Torture ; United States ; Warfare
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):728.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anticholesteremic Agents/therapeutic use ; *Biomedical Research/economics ; *Chemistry, Pharmaceutical/economics ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry/economics ; Humans ; *Research Personnel/economics ; *Technology, Pharmaceutical/economics
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    Publication Date: 2005-10-29
    Description: Global change will alter the supply of ecosystem services that are vital for human well-being. To investigate ecosystem service supply during the 21st century, we used a range of ecosystem models and scenarios of climate and land-use change to conduct a Europe-wide assessment. Large changes in climate and land use typically resulted in large changes in ecosystem service supply. Some of these trends may be positive (for example, increases in forest area and productivity) or offer opportunities (for example, "surplus land" for agricultural extensification and bioenergy production). However, many changes increase vulnerability as a result of a decreasing supply of ecosystem services (for example, declining soil fertility, declining water availability, increasing risk of forest fires), especially in the Mediterranean and mountain regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schroter, Dagmar -- Cramer, Wolfgang -- Leemans, Rik -- Prentice, I Colin -- Araujo, Miguel B -- Arnell, Nigel W -- Bondeau, Alberte -- Bugmann, Harald -- Carter, Timothy R -- Gracia, Carlos A -- de la Vega-Leinert, Anne C -- Erhard, Markus -- Ewert, Frank -- Glendining, Margaret -- House, Joanna I -- Kankaanpaa, Susanna -- Klein, Richard J T -- Lavorel, Sandra -- Lindner, Marcus -- Metzger, Marc J -- Meyer, Jeannette -- Mitchell, Timothy D -- Reginster, Isabelle -- Rounsevell, Mark -- Sabate, Santi -- Sitch, Stephen -- Smith, Ben -- Smith, Jo -- Smith, Pete -- Sykes, Martin T -- Thonicke, Kirsten -- Thuiller, Wilfried -- Tuck, Gill -- Zaehle, Sonke -- Zierl, Barbel -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1333-7. Epub 2005 Oct 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany. dagmar.schroeter@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254151" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Biodiversity ; Carbon ; Climate ; Conservation of Natural Resources ; Crops, Agricultural ; *Ecosystem ; Environment ; Europe ; Greenhouse Effect ; Humans ; Models, Statistical ; Models, Theoretical ; Socioeconomic Factors ; Trees/growth & development ; Urban Population ; Water Supply ; Wood
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Payne, Anthony G -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):208-9; author reply 208-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662728" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Evolution ; Diet ; Edible Grain/chemistry ; Fatty Acids, Unsaturated/analysis ; Humans ; *Inflammation ; *Longevity ; Myocardial Infarction/etiology ; *Nutritional Physiological Phenomena ; Resorcinols/analysis ; Thromboxane A2/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krajick, Kevin -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1410-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322433" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; *Conservation of Natural Resources ; *Ecosystem ; Geography ; Humans ; *Pest Control
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):962-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284156" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; *Consciousness ; Great Britain ; History, 20th Century ; History, 21st Century ; Humans ; Neurosciences/*history ; Pain Threshold ; Politics ; Religion
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1183-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731414" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use ; Cardiovascular Diseases/chemically induced/epidemiology ; Celecoxib ; Cyclooxygenase Inhibitors/*adverse effects/*therapeutic use ; *Drug Labeling ; Drug and Narcotic Control ; Humans ; Isoxazoles/adverse effects/therapeutic use ; Lactones/adverse effects/therapeutic use ; Pyrazoles/adverse effects/therapeutic use ; Stroke/chemically induced/epidemiology ; Sulfonamides/adverse effects/therapeutic use ; Sulfones/adverse effects/therapeutic use ; United States ; *United States Food and Drug Administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Dec 23;310(5756):1883.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16373542" target="_blank"〉PubMed〈/a〉
    Keywords: *Disaster Planning/economics ; *Disasters ; Humans
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    Publication Date: 2005-10-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):219-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16223999" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Simulation ; Crowding ; Disaster Planning ; Escape Reaction ; *Facility Design and Construction ; Humans ; *Safety Management ; September 11 Terrorist Attacks
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jiang, Dianhua -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363028" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Sep 30;309(5744):2149.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16195437" target="_blank"〉PubMed〈/a〉
    Keywords: *Awards and Prizes ; *Biomedical Research ; Female ; Humans ; Male ; *National Institutes of Health (U.S.) ; *Research Personnel ; United States ; *Women
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    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibbons, Ann -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845823" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anthropology, Physical ; Climate ; Emigration and Immigration ; England ; History, Ancient ; *Hominidae ; Humans ; *Paleontology ; Population Dynamics ; Time
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kueppers, Lara M -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1278-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311318" target="_blank"〉PubMed〈/a〉
    Keywords: *Climate ; *Developing Countries ; Humans ; *Models, Theoretical
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  • 41
    Publication Date: 2005-07-16
    Description: Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect in cellular proliferation, but was correlated with the induction of apoptotic markers, particularly in tissues characterized by rapid cellular turnover. The levels of apoptotic markers were also found to increase during aging in normal mice. Thus, accumulation of mtDNA mutations that promote apoptosis may be a central mechanism driving mammalian aging.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kujoth, G C -- Hiona, A -- Pugh, T D -- Someya, S -- Panzer, K -- Wohlgemuth, S E -- Hofer, T -- Seo, A Y -- Sullivan, R -- Jobling, W A -- Morrow, J D -- Van Remmen, H -- Sedivy, J M -- Yamasoba, T -- Tanokura, M -- Weindruch, R -- Leeuwenburgh, C -- Prolla, T A -- AG021905/AG/NIA NIH HHS/ -- AG16694/AG/NIA NIH HHS/ -- AG17994/AG/NIA NIH HHS/ -- AG18922/AG/NIA NIH HHS/ -- AG21042/AG/NIA NIH HHS/ -- DK48831/DK/NIDDK NIH HHS/ -- RR00095/RR/NCRR NIH HHS/ -- T32 AG00213/AG/NIA NIH HHS/ -- T32 GM07601/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):481-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020738" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/*physiology ; Amino Acid Substitution ; Animals ; *Apoptosis ; Caspase 3 ; Caspases/metabolism ; Cloning, Molecular ; DNA Damage ; DNA Fragmentation ; DNA, Mitochondrial/*genetics ; DNA-Directed DNA Polymerase/genetics ; Gene Targeting ; Humans ; Hydrogen Peroxide/metabolism ; Lipid Peroxidation ; Liver/metabolism ; Mice ; Mitochondria, Heart/metabolism ; Mitochondria, Liver/metabolism ; Muscle, Skeletal/metabolism ; *Mutation ; Myocardium/metabolism ; *Oxidative Stress ; Phenotype ; Presbycusis/etiology ; Reactive Oxygen Species/metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1595.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339414" target="_blank"〉PubMed〈/a〉
    Keywords: Biomedical Research/standards ; *Cell Line ; *Cloning, Organism ; Embryo Research ; Embryo, Mammalian/*cytology ; Humans ; *Publishing ; *Stem Cells
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):334.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831722" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/administration & dosage/adverse effects/*therapeutic use ; *Clinical Trials as Topic/standards ; Female ; HIV Infections/drug therapy/*prevention & control/*transmission ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/*prevention & control ; Institute of Medicine (U.S.) ; National Institutes of Health (U.S.) ; Nevirapine/administration & dosage/adverse effects/*therapeutic use ; Pilot Projects ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Uganda ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jorde, Lynn B -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):60-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. lbj@genetics.utah.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802591" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Alleles ; Animals ; Chromosome Mapping ; Chromosomes, Human/genetics ; Chromosomes, Mammalian/genetics ; Evolution, Molecular ; *Genome ; *Genome, Human ; Haplotypes ; Humans ; Linkage Disequilibrium ; Pan troglodytes/*genetics ; *Recombination, Genetic ; Sample Size ; Sequence Homology, Nucleic Acid
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  • 45
    Publication Date: 2005-08-27
    Description: CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism linking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MyD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peng, Guangyong -- Guo, Zhong -- Kiniwa, Yukiko -- Voo, Kui Shin -- Peng, Weiyi -- Fu, Tihui -- Wang, Daniel Y -- Li, Yanchun -- Wang, Helen Y -- Wang, Rong-Fu -- P01CA94237/CA/NCI NIH HHS/ -- P50 CA093459/CA/NCI NIH HHS/ -- P50CA58204/CA/NCI NIH HHS/ -- R01CA101795/CA/NCI NIH HHS/ -- R01CA90327/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1380-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123302" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing ; Adoptive Transfer ; Animals ; Antigens, Differentiation/genetics/physiology ; CD4-Positive T-Lymphocytes/*immunology ; Cell Line ; Cell Line, Tumor ; Humans ; Immune Tolerance ; Interleukin-1 Receptor-Associated Kinases ; Killer Cells, Natural/immunology ; Ligands ; Lymphocyte Activation ; Membrane Glycoproteins/genetics/*physiology ; Mice ; Myeloid Differentiation Factor 88 ; Neoplasm Transplantation ; Neoplasms, Experimental/immunology/pathology ; Oligodeoxyribonucleotides/immunology ; Phosphotransferases (Alcohol Group Acceptor)/genetics/physiology ; Poly G/immunology ; RNA Interference ; Receptors, Cell Surface/genetics/*physiology ; Receptors, Immunologic/genetics/physiology ; *Signal Transduction ; T-Lymphocyte Subsets/*immunology ; Toll-Like Receptor 8 ; Toll-Like Receptors
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  • 46
    Publication Date: 2005-04-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):490-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845824" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; *Anthropology, Physical ; Asia ; Chromosomes, Human, X/*genetics ; *Genes ; Genetic Variation ; Genetics, Population ; Haplotypes ; Hominidae/*genetics ; Humans ; Hybridization, Genetic ; Sequence Analysis, DNA ; X Chromosome/*genetics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1401-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933177" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Computer Simulation ; Dna ; Evolution, Molecular ; *Genome ; Humans ; Mammals/genetics ; Species Specificity
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):551-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/physiology ; Circadian Rhythm ; Female ; Gonadotropin-Releasing Hormone/physiology/secretion ; Humans ; Hypogonadism/genetics ; Kisspeptins ; Leptin/genetics/physiology ; Male ; Mutation ; Neurons/physiology ; Proteins/genetics/*physiology ; Puberty/*physiology ; Receptors, Cell Surface/genetics/metabolism ; Receptors, G-Protein-Coupled ; Receptors, Leptin ; Receptors, Neuropeptide/genetics/*physiology ; Reproduction ; Signal Transduction ; Tumor Suppressor Proteins
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  • 49
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Service, Robert F -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1609.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339426" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Environment ; Financing, Government ; Great Britain ; Humans ; International Cooperation ; Nanostructures/*toxicity ; *Nanotechnology ; Occupational Exposure ; *Research ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Dec 9;310(5754):1607.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16339425" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antimalarials/*pharmacology ; Artemisinins/*pharmacology/therapeutic use ; Cambodia ; Cost-Benefit Analysis ; Drug Resistance ; Drug Therapy, Combination ; French Guiana ; Humans ; Malaria/drug therapy/parasitology ; Plasmodium/*drug effects ; Senegal
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Christopher N -- New York, N.Y. -- Science. 2005 Jul 8;309(5732):255-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia. christopher.johnson@jcu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16002607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthropology ; Australia ; *Birds ; Carbon Isotopes ; Climate ; *Diet ; Dromaiidae ; *Ecosystem ; *Environment ; *Food Chain ; Humans ; *Mammals ; Marsupialia ; *Plants ; Poaceae ; Population Dynamics
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):184-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821057" target="_blank"〉PubMed〈/a〉
    Keywords: Bioterrorism/*legislation & jurisprudence ; Capital Punishment ; Child ; Foreign Professional Personnel/*legislation & jurisprudence ; HIV Infections/*transmission ; Humans ; Libya ; Medical Staff/*legislation & jurisprudence ; Politics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, Ian T -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1839.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790809" target="_blank"〉PubMed〈/a〉
    Keywords: Anticarcinogenic Agents/administration & dosage ; Developed Countries ; *Diet ; Gastrointestinal Neoplasms/*etiology/prevention & control ; Humans ; Inflammation ; Overnutrition
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2005 Apr 8;308(5719):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15821056" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes ; Acquired Immunodeficiency Syndrome/epidemiology ; Biomedical Research/economics/legislation & jurisprudence/trends ; Crime/*legislation & jurisprudence ; Emigration and Immigration/legislation & jurisprudence ; Government Agencies ; Humans ; Libya/epidemiology ; Medical Staff ; Research/economics/legislation & jurisprudence/*trends
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mervis, Jeffrey -- New York, N.Y. -- Science. 2005 Jul 29;309(5735):721.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16051780" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Pharmaceutical ; Clinical Trials as Topic ; Drug Design ; Drug Evaluation, Preclinical ; *Drug Industry ; Humans ; *Pharmaceutical Preparations ; Technology, Pharmaceutical
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuo, Arthur D -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1686-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Mechanical Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA. artkuo@umich.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151001" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioelectric Energy Sources ; Biomechanical Phenomena ; *Electricity ; *Energy Metabolism ; Humans ; *Walking ; Weight-Bearing
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):602.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254156" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Proliferation/*drug effects ; Ciliary Neurotrophic Factor/*pharmacology ; Humans ; Hypothalamus/cytology/*drug effects ; Mice ; Neurons/cytology/*drug effects ; Weight Loss/*drug effects
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  • 58
    Publication Date: 2005-05-21
    Description: Gene marking with replication-defective retroviral vectors has been used for more than 20 years to track the in vivo fate of cell clones. We demonstrate that retroviral integrations themselves may trigger nonmalignant clonal expansion in murine long-term hematopoiesis. All 29 insertions recovered from clones dominating in serially transplanted recipients affected loci with an established or potential role in the self-renewal or survival of hematopoietic stem cells. Transcriptional dysregulation occurred in all 12 insertion sites analyzed. These findings have major implications for diagnostic gene marking and the discovery of genes regulating stem cell turnover.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kustikova, Olga -- Fehse, Boris -- Modlich, Ute -- Yang, Min -- Dullmann, Jochen -- Kamino, Kenji -- von Neuhoff, Nils -- Schlegelberger, Brigitte -- Li, Zhixiong -- Baum, Christopher -- New York, N.Y. -- Science. 2005 May 20;308(5725):1171-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone Marrow Transplantation, University Hospital Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15905401" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD34/genetics ; Bone Marrow Transplantation ; DNA-Binding Proteins/genetics ; Down-Regulation ; *Genetic Vectors ; *Hematopoiesis ; *Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*physiology ; Humans ; Ligase Chain Reaction ; Mice ; Mice, Inbred C57BL ; *Mutagenesis, Insertional ; Polymerase Chain Reaction ; Proto-Oncogenes/genetics ; Retroviridae/*genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transgenes ; Up-Regulation ; *Virus Integration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):416-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239442" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastocyst/cytology ; *Cell Line ; Embryo Implantation ; Embryo Research/economics/*ethics ; Embryo, Mammalian/*cytology ; Female ; Financing, Government ; Humans ; Mice ; Nuclear Transfer Techniques ; *Pluripotent Stem Cells ; Research Support as Topic ; *Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bosch, Xavier -- New York, N.Y. -- Science. 2005 Sep 16;309(5742):1799.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16166486" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Child ; *Clinical Trials as Topic ; *Drug Approval ; *European Union ; Humans ; *Legislation, Drug ; *Pediatrics ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1468-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Evolution, Molecular ; *Genome ; *Genome, Human ; Genomics ; Humans ; Pan troglodytes/*genetics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Cooperative Behavior ; Game Theory ; Humans ; Memory ; Social Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994526" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Chromatin/physiology ; *Gene Expression Regulation ; *Genes ; *Genome, Human ; Humans ; RNA, Untranslated/genetics/physiology ; Regulatory Sequences, Nucleic Acid
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1753.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357233" target="_blank"〉PubMed〈/a〉
    Keywords: *Academic Medical Centers/economics/manpower ; Budgets ; *Disasters ; *Faculty ; Humans ; Louisiana ; *Personnel Downsizing ; *Schools, Medical/economics/manpower ; *Universities/economics/manpower
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 25;307(5713):1179.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15731410" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Size ; Bone and Bones/*chemistry ; DNA/*chemistry ; *Fossils ; History, Ancient ; *Hominidae/anatomy & histology/classification/genetics ; Humans ; Indonesia ; Microcephaly/history ; Ribs ; *Sequence Analysis, DNA ; Skeleton
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bradford, Barry -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994508" target="_blank"〉PubMed〈/a〉
    Keywords: Beginning of Human Life ; Christianity ; Embryo Research/*ethics ; Humans ; *Stem Cells ; United States
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jul 1;309(5731):85.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15994531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Differentiation ; Cell Division ; Cell Nucleus/physiology ; Cloning, Organism ; Cues ; Embryo, Mammalian/cytology ; Forecasting ; *Gene Expression Regulation ; Humans ; Nuclear Transfer Techniques ; Oocytes/cytology/*physiology ; Stem Cells/cytology/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culotta, Elizabeth -- New York, N.Y. -- Science. 2005 Feb 11;307(5711):841.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705826" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; DNA, Mitochondrial/analysis ; Female ; Fossils ; Hominidae/classification/*genetics ; Humans ; *Hybridization, Genetic ; Male ; *Sexual Behavior
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):755.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272086" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; *Anti-Infective Agents ; *Bioterrorism ; Communicable Diseases/drug therapy ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States ; United States Dept. of Health and Human Services/*legislation & ; jurisprudence/*organization & administration ; *Vaccines
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, Elizabeth -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15790840" target="_blank"〉PubMed〈/a〉
    Keywords: Antibiosis ; Archaea/genetics/*isolation & purification ; Bacteria/genetics/growth & development/*isolation & purification/metabolism ; Bacterial Infections/*microbiology ; Biofilms/growth & development ; Ecosystem ; Genes, Archaeal ; Genes, Bacterial ; Gingiva/microbiology ; Halitosis/microbiology ; Humans ; Mouth/*microbiology ; Mouth Diseases/*microbiology ; Mouthwashes ; Sequence Analysis, DNA ; Tongue/microbiology ; Tooth/microbiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brauer, Jurgen -- New York, N.Y. -- Science. 2005 May 6;308(5723):791-2; author reply 791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15879191" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; Conservation of Natural Resources ; *Economics ; Humans
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  • 72
    Publication Date: 2005-11-19
    Description: The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness. The PDEs inactivate adenosine 3',5'-monophosphate (cAMP), a second messenger implicated in learning, memory, and mood. We show that DISC1 interacts with the UCR2 domain of PDE4B and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and an increase in PDE4B activity. We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Millar, J Kirsty -- Pickard, Benjamin S -- Mackie, Shaun -- James, Rachel -- Christie, Sheila -- Buchanan, Sebastienne R -- Malloy, M Pat -- Chubb, Jennifer E -- Huston, Elaine -- Baillie, George S -- Thomson, Pippa A -- Hill, Elaine V -- Brandon, Nicholas J -- Rain, Jean-Christophe -- Camargo, L Miguel -- Whiting, Paul J -- Houslay, Miles D -- Blackwood, Douglas H R -- Muir, Walter J -- Porteous, David J -- G8604010/Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1187-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK. Kirsty.Millar@ed.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293762" target="_blank"〉PubMed〈/a〉
    Keywords: 3',5'-Cyclic-AMP Phosphodiesterases/*genetics/metabolism ; Adult ; Affective Disorders, Psychotic/genetics/metabolism ; Animals ; Cadherins/genetics ; Cell Line ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 16 ; Cyclic AMP/*metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Enzyme Activation ; Genetic Predisposition to Disease ; Humans ; Male ; Nerve Tissue Proteins/*genetics/metabolism ; Protein Binding ; Rats ; Schizophrenia/enzymology/*genetics/metabolism ; *Signal Transduction ; Translocation, Genetic
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  • 73
    Publication Date: 2005-12-17
    Description: Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes. Here we show that zebrafish golden mutants share these melanosomal changes and that golden encodes a putative cation exchanger slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its precursor. The human ortholog is highly similar in sequence and functional in zebrafish. The evolutionarily conserved ancestral allele of a human coding polymorphism predominates in African and East Asian populations. In contrast, the variant allele is nearly fixed in European populations, is associated with a substantial reduction in regional heterozygosity, and correlates with lighter skin pigmentation in admixed populations, suggesting a key role for the SLC24A5 gene in human pigmentation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamason, Rebecca L -- Mohideen, Manzoor-Ali P K -- Mest, Jason R -- Wong, Andrew C -- Norton, Heather L -- Aros, Michele C -- Jurynec, Michael J -- Mao, Xianyun -- Humphreville, Vanessa R -- Humbert, Jasper E -- Sinha, Soniya -- Moore, Jessica L -- Jagadeeswaran, Pudur -- Zhao, Wei -- Ning, Gang -- Makalowska, Izabela -- McKeigue, Paul M -- O'donnell, David -- Kittles, Rick -- Parra, Esteban J -- Mangini, Nancy J -- Grunwald, David J -- Shriver, Mark D -- Canfield, Victor A -- Cheng, Keith C -- CA73935/CA/NCI NIH HHS/ -- EY11308/EY/NEI NIH HHS/ -- HD37572/HD/NICHD NIH HHS/ -- HD40179/HD/NICHD NIH HHS/ -- HG002154/HG/NHGRI NIH HHS/ -- HL077910/HL/NHLBI NIH HHS/ -- RR017441/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1782-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16357253" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/genetics ; African Continental Ancestry Group/genetics ; Alanine/genetics ; Alleles ; Amino Acid Sequence ; Animals ; Antiporters/chemistry/*genetics/physiology ; Asian Continental Ancestry Group/genetics ; Biological Evolution ; Calcium/metabolism ; European Continental Ancestry Group/genetics ; Gene Frequency ; Genes ; Genetic Variation ; Haplotypes ; Heterozygote ; Humans ; Ion Transport ; Melanins/analysis ; Melanosomes/chemistry/ultrastructure ; Mice ; Molecular Sequence Data ; Multifactorial Inheritance ; Mutation ; Pigment Epithelium of Eye/chemistry/ultrastructure ; Polymorphism, Single Nucleotide ; Selection, Genetic ; Skin Pigmentation/*genetics ; Threonine/genetics ; Zebrafish/embryology/*genetics/metabolism ; Zebrafish Proteins/chemistry/*genetics/physiology
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-11-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):952-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284148" target="_blank"〉PubMed〈/a〉
    Keywords: Antiviral Agents/*supply & distribution ; Cell Line ; *Disease Outbreaks/prevention & control ; Financing, Government ; Humans ; Influenza A Virus, H5N1 Subtype/growth & development/immunology/pathogenicity ; Influenza A virus/growth & development/immunology ; Influenza Vaccines/*economics ; Influenza, Human/drug therapy/*epidemiology/prevention & control/*virology ; United States ; Virus Cultivation
    Print ISSN: 0036-8075
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Oct 7;310(5745):28-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16210501" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; Bioterrorism ; Chick Embryo/virology ; Containment of Biohazards ; Disease Outbreaks/history ; Editorial Policies ; *Genes, Viral ; Genome, Viral ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/*metabolism ; History, 20th Century ; Humans ; Influenza A virus/*genetics/*pathogenicity/physiology ; Influenza, Human/epidemiology/history/*virology ; Mice ; Neuraminidase/genetics/metabolism ; Publishing ; RNA Replicase/genetics/metabolism ; United States ; Virulence ; Virus Replication
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Russell -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2007-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of Auckland, Auckland 92019, New Zealand. rd.gray@auckland.ac.nz〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179464" target="_blank"〉PubMed〈/a〉
    Keywords: Asia ; *Cultural Evolution ; Databases, Factual ; History, Ancient ; Humans ; *Language ; *Linguistics ; Pacific Islands ; Papua New Guinea ; Software ; Time Factors
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogel, Gretchen -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):345.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661989" target="_blank"〉PubMed〈/a〉
    Keywords: *Communicable Disease Control ; Communicable Diseases/diagnosis ; *Disasters ; *Disease Notification ; Disease Outbreaks/*prevention & control ; Epidemiologic Methods ; Humans ; India ; Indian Ocean ; Indonesia ; *Population Surveillance ; Relief Work ; Sri Lanka ; World Health Organization
    Print ISSN: 0036-8075
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  • 78
    Publication Date: 2005-07-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greene, Mark -- Schill, Kathryn -- Takahashi, Shoji -- Bateman-House, Alison -- Beauchamp, Tom -- Bok, Hilary -- Cheney, Dorothy -- Coyle, Joseph -- Deacon, Terrence -- Dennett, Daniel -- Donovan, Peter -- Flanagan, Owen -- Goldman, Steven -- Greely, Henry -- Martin, Lee -- Miller, Earl -- Mueller, Dawn -- Siegel, Andrew -- Solter, Davor -- Gearhart, John -- McKhann, Guy -- Faden, Ruth -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):385-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Philosophy, University of Delaware, Newark, DE 19716, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020716" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animal Experimentation/*ethics ; Animals ; Brain/anatomy & histology/physiology ; Cell Line ; *Ethics, Research ; Humans ; Mental Processes ; Moral Obligations ; *Morals ; Neurons/cytology/physiology/*transplantation ; *Primates/psychology ; Stem Cell Transplantation/*ethics ; Transplantation Chimera ; Transplantation, Heterologous/*ethics
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  • 79
    Publication Date: 2005-06-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Jun 3;308(5727):1391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15933166" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen Antagonists/*toxicity ; Animals ; Endocrine Glands/*drug effects ; Environmental Pollutants/toxicity ; Epigenesis, Genetic/drug effects ; Female ; Fertility/*drug effects/genetics ; Humans ; Infertility, Male/chemically induced/genetics ; Inheritance Patterns ; Insecticides/*toxicity ; Male ; Methoxychlor/*toxicity ; Oxazoles/*toxicity ; Pregnancy
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  • 80
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Persaud, Raj -- New York, N.Y. -- Science. 2005 Mar 25;307(5717):1873-5; author reply 1873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15793899" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Iraq ; Military Personnel/*psychology ; Politics ; *Prisoners ; *Psychology, Social ; Torture/*psychology ; United States
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  • 81
    Publication Date: 2005-01-18
    Description: Amyloid fibrils commonly exhibit multiple distinct morphologies in electron microscope and atomic force microscope images, often within a single image field. By using electron microscopy and solid-state nuclear magnetic resonance measurements on fibrils formed by the 40-residue beta-amyloid peptide of Alzheimer's disease (Abeta(1-40)), we show that different fibril morphologies have different underlying molecular structures, that the predominant structure can be controlled by subtle variations in fibril growth conditions, and that both morphology and molecular structure are self-propagating when fibrils grow from preformed seeds. Different Abeta(1-40) fibril morphologies also have significantly different toxicities in neuronal cell cultures. These results have implications for the mechanism of amyloid formation, the phenomenon of strains in prion diseases, the role of amyloid fibrils in amyloid diseases, and the development of amyloid-based nano-materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petkova, Aneta T -- Leapman, Richard D -- Guo, Zhihong -- Yau, Wai-Ming -- Mattson, Mark P -- Tycko, Robert -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):262-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, MD 20892-0520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653506" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amyloid beta-Peptides/*chemistry/toxicity/*ultrastructure ; Animals ; Cells, Cultured ; Chemistry, Physical ; Hippocampus/cytology ; Humans ; Hydrogen Bonding ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; Molecular Structure ; Neurons/cytology/drug effects ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Fragments/*chemistry/toxicity/*ultrastructure ; Physicochemical Phenomena ; Protein Conformation ; Protein Structure, Secondary ; Rats
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  • 82
    Publication Date: 2005-01-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miller, Timothy M -- Cleveland, Don W -- R37 NS027036/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):361-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research and the Department of Medicine and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15661995" target="_blank"〉PubMed〈/a〉
    Keywords: Amyotrophic Lateral Sclerosis/*drug therapy ; Animals ; Anti-Bacterial Agents/pharmacology/*therapeutic use ; Brain/metabolism ; Ceftriaxone/pharmacology/*therapeutic use ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Excitatory Amino Acid Transporter 2/genetics/metabolism ; Glutamic Acid/metabolism ; Humans ; Mice ; Motor Neurons/physiology ; Neurodegenerative Diseases/*drug therapy ; Spinal Cord/metabolism ; Synapses/physiology ; Synaptic Transmission ; beta-Lactams/pharmacology/*therapeutic use
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  • 83
    Publication Date: 2005-12-03
    Description: Proper chromosome segregation requires the attachment of sister kinetochores to microtubules from opposite spindle poles to form bi-oriented chromosomes on the metaphase spindle. The chromosome passenger complex containing Survivin and the kinase Aurora B regulates this process from the centromeres. We report that a de-ubiquitinating enzyme, hFAM, regulates chromosome alignment and segregation by controlling both the dynamic association of Survivin with centromeres and the proper targeting of Survivin and Aurora B to centromeres. Survivin is ubiquitinated in mitosis through both Lys(48) and Lys(63) ubiquitin linkages. Lys(63) de-ubiquitination mediated by hFAM is required for the dissociation of Survivin from centromeres, whereas Lys(63) ubiquitination mediated by the ubiquitin binding protein Ufd1 is required for the association of Survivin with centromeres. Thus, ubiquitinaton regulates dynamic protein-protein interactions and chromosome segregation independently of protein degradation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vong, Queenie P -- Cao, Kan -- Li, Hoi Y -- Iglesias, Pablo A -- Zheng, Yixian -- GM56312/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Dec 2;310(5753):1499-504.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, 3520 San Martin Drive, Baltimore, MD 21218, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16322459" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Aurora Kinase B ; Aurora Kinases ; Centromere/*metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosome Segregation/*physiology ; Egg Proteins/metabolism ; Endopeptidases/metabolism ; HeLa Cells ; Humans ; Inhibitor of Apoptosis Proteins ; Lysine/metabolism ; Microtubule-Associated Proteins/metabolism ; Molecular Sequence Data ; Neoplasm Proteins/metabolism ; Protein Binding ; Protein-Serine-Threonine Kinases/metabolism ; Ubiquitin/*metabolism ; Ubiquitin Thiolesterase ; Xenopus ; Xenopus Proteins/*metabolism
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Apr 29;308(5722):610-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronauts ; *Biological Science Disciplines ; Humans ; *Research/economics ; Research Support as Topic ; *Space Flight ; *Spacecraft ; United States ; *United States National Aeronautics and Space ; Administration/economics/organization & administration
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, Linda J -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363030" target="_blank"〉PubMed〈/a〉
    Keywords: Asia/ethnology ; *Asian Americans ; *Career Mobility ; *Foreign Professional Personnel ; Humans ; Science/*manpower ; *Societies, Scientific/organization & administration ; United States
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  • 86
    Publication Date: 2005-08-06
    Description: MicroRNAs (miRNAs) are approximately 21-nucleotide-long RNA molecules regulating gene expression in multicellular eukaryotes. In metazoa, miRNAs act by imperfectly base-pairing with the 3' untranslated region of target messenger RNAs (mRNAs) and repressing protein accumulation by an unknown mechanism. We demonstrate that endogenous let-7 microribonucleoproteins (miRNPs) or the tethering of Argonaute (Ago) proteins to reporter mRNAs in human cells inhibit translation initiation. M(7)G-cap-independent translation is not subject to repression, suggesting that miRNPs interfere with recognition of the cap. Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pillai, Ramesh S -- Bhattacharyya, Suvendra N -- Artus, Caroline G -- Zoller, Tabea -- Cougot, Nicolas -- Basyuk, Eugenia -- Bertrand, Edouard -- Filipowicz, Witold -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1573-6. Epub 2005 Aug 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16081698" target="_blank"〉PubMed〈/a〉
    Keywords: Argonaute Proteins ; Eukaryotic Initiation Factor-2 ; HeLa Cells ; Humans ; MicroRNAs/analysis/*physiology ; *Peptide Chain Initiation, Translational ; Peptide Initiation Factors/analysis/physiology ; RNA Caps/metabolism ; RNA, Messenger/analysis ; Ribonucleoproteins/analysis/*physiology
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  • 87
    Publication Date: 2005-11-19
    Description: Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Xinquan -- Rickert, Mathias -- Garcia, K Christopher -- AI51321/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 18;310(5751):1159-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16293754" target="_blank"〉PubMed〈/a〉
    Keywords: Crystallography, X-Ray ; Humans ; Interleukin Receptor Common gamma Subunit ; Interleukin-2/*chemistry/metabolism/therapeutic use ; Interleukin-2 Receptor alpha Subunit ; Interleukin-2 Receptor beta Subunit ; Models, Molecular ; Mutation ; Protein Binding ; Protein Conformation ; Receptors, Interleukin/*chemistry/metabolism ; Receptors, Interleukin-2/*chemistry/genetics/metabolism ; Recombinant Proteins/therapeutic use ; Severe Combined Immunodeficiency/genetics
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  • 88
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gruters, Rob A -- Osterhaus, Albert D M E -- New York, N.Y. -- Science. 2005 May 27;308(5726):1258-9; author reply 1258-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15919975" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; HIV/*physiology ; HIV Infections/virology ; Humans ; Smallpox/*virology ; Vaccinia virus/*physiology ; Variola virus/*physiology
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  • 89
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-05-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aldridge, James W -- New York, N.Y. -- Science. 2005 May 13;308(5724):954.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15890862" target="_blank"〉PubMed〈/a〉
    Keywords: Basal Ganglia/*physiology/physiopathology ; *Behavior ; Brain/*physiology ; *Gambling ; Humans ; Magnetic Resonance Imaging
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  • 90
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-03-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, Jocelyn -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1544-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15761128" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Clinical Trials as Topic ; Genetic Diseases, X-Linked/*therapy ; *Genetic Therapy/adverse effects ; Genetic Vectors ; Haplorhini ; Humans ; Infant ; Leukemia, T-Cell/etiology ; Mice ; Oncogenes ; Retroviridae/genetics ; Severe Combined Immunodeficiency/*therapy ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, R McNeill -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):58-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biology, University of Leeds, Leeds LS2 9JT, UK. r.m.alexander@leeds.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802589" target="_blank"〉PubMed〈/a〉
    Keywords: Biomechanical Phenomena ; Energy Metabolism ; Gravitation ; Humans ; Models, Anatomic ; Oxygen Consumption ; *Robotics ; *Walking/physiology
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  • 92
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Byravan, Sujatha -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):557-8; author reply 557-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16044529" target="_blank"〉PubMed〈/a〉
    Keywords: Drug Costs ; Drug Industry/*legislation & jurisprudence ; *Drugs, Generic ; Humans ; India ; *Legislation, Drug ; Patents as Topic ; Poverty
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  • 93
    Publication Date: 2005-11-15
    Description: The ancestry of modern Europeans is a subject of debate among geneticists, archaeologists, and anthropologists. A crucial question is the extent to which Europeans are descended from the first European farmers in the Neolithic Age 7500 years ago or from Paleolithic hunter-gatherers who were present in Europe since 40,000 years ago. Here we present an analysis of ancient DNA from early European farmers. We successfully extracted and sequenced intact stretches of maternally inherited mitochondrial DNA (mtDNA) from 24 out of 57 Neolithic skeletons from various locations in Germany, Austria, and Hungary. We found that 25% of the Neolithic farmers had one characteristic mtDNA type and that this type formerly was widespread among Neolithic farmers in Central Europe. Europeans today have a 150-times lower frequency (0.2%) of this mtDNA type, revealing that these first Neolithic farmers did not have a strong genetic influence on modern European female lineages. Our finding lends weight to a proposed Paleolithic ancestry for modern Europeans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haak, Wolfgang -- Forster, Peter -- Bramanti, Barbara -- Matsumura, Shuichi -- Brandt, Guido -- Tanzer, Marc -- Villems, Richard -- Renfrew, Colin -- Gronenborn, Detlef -- Alt, Kurt Werner -- Burger, Joachim -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):1016-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Anthropologie, Johannes Gutenberg Universitat Mainz, Saarstrasse 21, D-55099 Mainz, Germany. haakw@uni-mainz.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284177" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*history ; Austria ; Base Sequence ; Computer Simulation ; Cultural Evolution ; DNA, Mitochondrial/chemistry/classification/*genetics/history ; Emigration and Immigration ; Europe ; European Continental Ancestry Group/*genetics/history ; Female ; Gene Frequency ; Genetic Drift ; Genetics, Population ; Germany ; Haplotypes ; History, Ancient ; Humans ; Hungary ; Male ; Molecular Sequence Data ; Population Dynamics
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  • 94
    Publication Date: 2005-07-23
    Description: Many large animal species have a high risk of extinction. This is usually thought to result simply from the way that species traits associated with vulnerability, such as low reproductive rates, scale with body size. In a broad-scale analysis of extinction risk in mammals, we find two additional patterns in the size selectivity of extinction risk. First, impacts of both intrinsic and environmental factors increase sharply above a threshold body mass around 3 kilograms. Second, whereas extinction risk in smaller species is driven by environmental factors, in larger species it is driven by a combination of environmental factors and intrinsic traits. Thus, the disadvantages of large size are greater than generally recognized, and future loss of large mammal biodiversity could be far more rapid than expected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cardillo, Marcel -- Mace, Georgina M -- Jones, Kate E -- Bielby, Jon -- Bininda-Emonds, Olaf R P -- Sechrest, Wes -- Orme, C David L -- Purvis, Andy -- New York, N.Y. -- Science. 2005 Aug 19;309(5738):1239-41. Epub 2005 Jul 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology, Imperial College London, Silwood Park, Ascot SL5 7PY, UK. m.cardillo@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16037416" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Biological Evolution ; *Body Size ; Body Weight ; Conservation of Natural Resources ; *Ecosystem ; *Environment ; Female ; Homing Behavior ; Humans ; *Mammals/physiology ; Models, Biological ; Models, Statistical ; Population Density ; Population Dynamics ; Pregnancy ; Pregnancy, Animal ; Regression Analysis ; Risk ; Weaning
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  • 95
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-02-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2005 Jan 28;307(5709):492-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681345" target="_blank"〉PubMed〈/a〉
    Keywords: *Career Choice ; Career Mobility ; *Engineering ; Female ; Genes ; Humans ; Male ; *Prejudice ; *Science ; *Sex Characteristics
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  • 96
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-01-22
    Description: The epidemic of obesity-associated diabetes is a major crisis in modern societies, in which food is plentiful and exercise is optional. The biological basis of this problem has been explored from evolutionary and mechanistic perspectives. Evolutionary theories, focusing on the potential survival advantages of "thrifty" genes that are now maladaptive, are of great interest but are inherently speculative and difficult to prove. Mechanistic studies have revealed numerous fat-derived molecules and a link to inflammation that, together, are hypothesized to underlie the obesity-diabetes connection and thereby represent prospective targets for therapeutic intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lazar, Mitchell A -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):373-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6149, USA. lazar@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15662001" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/metabolism ; Adipose Tissue/metabolism ; Animals ; Biological Evolution ; Cytokines/metabolism ; Diabetes Mellitus, Type 2/epidemiology/*etiology/physiopathology ; Epigenesis, Genetic ; Fetal Nutrition Disorders/physiopathology ; Glucose/metabolism ; Humans ; Immunity, Innate ; Inflammation/physiopathology ; Insulin/physiology ; Insulin Resistance ; Leptin/blood/genetics/physiology ; Lipid Metabolism ; Macrophages/immunology/metabolism ; Obesity/*complications/epidemiology/genetics/physiopathology ; Phenotype ; Proteins/metabolism
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  • 97
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dobson, Andrew P -- New York, N.Y. -- Science. 2005 Oct 28;310(5748):628-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544-1003, USA. dobber@princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16254175" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chiroptera/physiology/*virology ; Communicable Diseases, Emerging/*transmission/virology ; *Disease Reservoirs ; Humans ; *SARS Virus ; Severe Acute Respiratory Syndrome/*transmission/virology ; Viverridae/virology
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  • 98
    Publication Date: 2005-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altshuler, David -- Clark, Andrew G -- New York, N.Y. -- Science. 2005 Feb 18;307(5712):1052-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of Harvard and Massachusetts Institute of Technology, and Massachusetts General Hospital, Boston, MA 02114, USA. altshuler@molbio.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15718454" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans/*genetics ; Asian Continental Ancestry Group/*genetics ; Chromosome Mapping ; Databases, Genetic ; European Continental Ancestry Group/*genetics ; Evolution, Molecular ; Female ; Gene Frequency ; Genetic Markers ; *Genetic Predisposition to Disease ; Genetic Variation ; *Genome, Human ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Male ; *Multifactorial Inheritance ; Mutation ; *Polymorphism, Single Nucleotide ; Recombination, Genetic ; Risk Factors ; Selection, Genetic
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  • 99
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-09-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guzman, Maria G -- New York, N.Y. -- Science. 2005 Sep 2;309(5740):1495-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, Instituto de Medicina Tropical "Pedro Kouri" Autopista Novia del Mediodia, Km 1/2, Post Office Box Mariano 13, Habana, Cuba. lupe@ipk.sld.cu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16141052" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cuba/epidemiology ; Dengue/epidemiology/prevention & control/virology ; Dengue Virus/chemistry/immunology ; Humans ; Risk Factors ; Severe Dengue/*epidemiology ; Viral Vaccines
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  • 100
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2005-07-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caplan, Arthur L -- New York, N.Y. -- Science. 2005 Jul 22;309(5734):535.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16040671" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Embryo Research/*ethics ; Eugenics ; Euthanasia/ethics ; Euthanasia, Passive/*ethics ; Human Experimentation/ethics ; Humans ; *National Socialism
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