Publikationsdatum:
1994-11-11
Beschreibung:
Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shores, E W -- Huang, K -- Tran, T -- Lee, E -- Grinberg, A -- Love, P E -- New York, N.Y. -- Science. 1994 Nov 11;266(5187):1047-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7526464" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amino Acid Sequence
;
Animals
;
Antigens, CD/analysis/genetics
;
Antigens, CD4/analysis
;
Antigens, CD5
;
Antigens, CD8/analysis
;
Antigens, Differentiation, T-Lymphocyte/analysis
;
*DNA-Binding Proteins
;
Down-Regulation
;
Gene Expression
;
*Homeodomain Proteins
;
Lectins, C-Type
;
Lymph Nodes/immunology
;
Membrane Proteins/genetics/*physiology
;
Mice
;
Mice, Transgenic
;
Molecular Sequence Data
;
Proteins/genetics
;
RNA, Messenger/genetics/metabolism
;
Receptors, Antigen, T-Cell/genetics/*physiology
;
Signal Transduction
;
T-Lymphocytes/cytology/*immunology
;
Thymus Gland/immunology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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