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  • Cells, Cultured  (47)
  • Cell Line  (32)
  • American Association for the Advancement of Science (AAAS)  (76)
  • American Chemical Society
  • American Geophysical Union (AGU)
  • American Physical Society
  • MDPI
  • Public Library of Science
  • 2015-2019
  • 1980-1984  (76)
  • 1945-1949
  • 1983  (76)
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  • American Association for the Advancement of Science (AAAS)  (76)
  • American Chemical Society
  • American Geophysical Union (AGU)
  • American Physical Society
  • MDPI
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  • 2015-2019
  • 1980-1984  (76)
  • 1945-1949
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  • 1
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    Homeostasis of the antibody response: immunoregulation by NK cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-11
    Beschreibung: When injected into mice, the synthetic double-stranded polynucleotide poly(inosinic) X poly(cytidylic) acid induces high natural killer (NK) cell activity within 4 to 12 hours. Induction of NK activity in mice immunized 2 or 3 days previously, or the addition of NK cells to cultures immunized in vitro 2 or 3 days previously, promotes early termination of the ongoing primary immunoglobulin M antibody response. A target for NK cells is a population of accessory cells that has interacted with antigen and is necessary for sustaining the antibody response. The inference is strong that NK cells induced normally by immunization also terminate the usual antibody response in vivo by elimination of antigen-exposed accessory cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abruzzo, L V -- Rowley, D A -- 5-T32-CA-09267/CA/NCI NIH HHS/ -- R01-10242/PHS HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):581-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6685343" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Antibody Formation ; Antibody-Producing Cells/immunology ; Cells, Cultured ; Homeostasis ; Killer Cells, Natural/*immunology/radiation effects ; Lymphocyte Cooperation ; Lymphocytes/*immunology ; Mice ; Poly I-C/immunology ; Spleen/immunology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Primary murine bone marrow cultures support continuous growth of infectious human trypanosomes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-22
    Beschreibung: The human parasite Trypanosoma brucei gambiense grew continuously at 37 degrees C in primary cultures of murine bone marrow. Cultured parasites remained virulent for mice. Rapid parasite growth coincided with the appearance of adherent adipocyte-epitheloid cell aggregates that also promoted hematopoiesis. This culture system should permit studies of host cell control of trypanosome proliferation, pathogenic effects of trypanosomes on blood cell development, and the relative trypanocidal and marrow suppressive activities of drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balber, A E -- CA 14049/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836284" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bone Marrow ; Cells, Cultured ; Culture Media ; Humans ; Mice ; Mice, Inbred BALB C ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei gambiense/*growth & development ; Trypanosomiasis, African/parasitology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Collagen formation by the hepatocyte in primary monolayer culture and in vivo (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-18
    Beschreibung: Immunohistochemical techniques were used to confirm biochemical evidence that parenchymal cells isolated from adult rat liver and maintained in nonreplicating monolayer culture for 2 days synthesized type IV basement membrane collagen. On continued incubation in serum-free medium, the hepatocytes also synthesized the interstitial collagens, types I and III. Consistent with these results in culture, type IV collagen was localized to the hepatocytes in slices of pathologic rat liver. Hence collagen formation is a previously unrecognized function of the hepatocyte that may be important in the pathogenesis of liver fibrosis or cirrhosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diegelmann, R F -- Guzelian, P S -- Gay, R -- Gay, S -- AM18976/AM/NIADDK NIH HHS/ -- DE02570/DE/NIDCR NIH HHS/ -- HL11310/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Mar 18;219(4590):1343-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828863" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Basement Membrane/metabolism ; Cells, Cultured ; Collagen/*biosynthesis/immunology ; Liver/cytology/*metabolism ; Molecular Weight ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Transformation of Bloom's syndrome fibroblasts by DNA transfection (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Nonmalignant diploid human fibroblast cells (GM3498B) derived from a skin biopsy of a patient with Bloom's syndrome have been transformed by transfection with DNA from a tumorigenic mouse cell line (Ha-8) carrying a single copy of the Harvey murine sarcoma virus (Ha-MuSV) genome. The transformed cell lines have an extended life-span, form colonies in agarose, and proliferate in nude mice--characteristics of neoplastic transformation. Like the parental cells, they also exhibit a high spontaneous level of sister chromatid exchanges. Finally, the transformed cells contain most, if not all, of the Ha-MuSV genome as well as the human rasH sequence. These experiments show that these diploid nonmalignant human cells can be used as recipients in transfection experiments for studying the genetic control of neoplastic transformation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniger, J -- Di Paolo, J A -- Popescu, N C -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1144-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6648529" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bloom Syndrome/*genetics ; Cell Adhesion ; *Cell Transformation, Neoplastic ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Humans ; Oncogenes ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    High efficiency DNA-mediated transformation of primate cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-05
    Beschreibung: Tissue culture cells from several mammalian species, including three primate lines, were transfected with recombinant vectors carrying Escherichia coli xanthine-guanine phosphoribosyltransferase or Tn5 aminoglycoside phosphotransferase dominant selectable markers. Human HeLa and SV40-transformed xeroderma pigmentosum cells exhibited stable transformation frequencies of at least 10(-3) (0.1 percent). CV-1, an African green monkey kidney cell line, could be stably transformed with the exceptionally high frequency of 6 X 10(-2) (6 percent).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorman, C -- Padmanabhan, R -- Howard, B H -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):551-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6306768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Avian Sarcoma Viruses/genetics ; Cell Line ; Cercopithecus aethiops ; Cricetinae ; Cricetulus ; DNA, Recombinant/*metabolism ; Genetic Vectors ; HeLa Cells/metabolism ; Humans ; Mice ; Plasmids ; *Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: Cultured bronchial epithelial and fibroblastic cells from humans were used to study DNA damage and toxicity caused by formaldehyde. Formaldehyde caused the formation of cross-links between DNA and proteins, caused single-strand breaks in DNA, and inhibited the resealing of single-strand breaks produced by ionizing radiation. Formaldehyde also inhibited the unscheduled DNA synthesis that occurs after exposure of cells to ultraviolet irradiation or to benzo[a]pyrene diolexpoxide but at doses substantially higher than those required to inhibit the resealing of x-ray-induced single-strand breaks. Therefore, formaldehyde could exert its mutagenic and carcinogenic effects by both damaging DNA and inhibiting DNA repair.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grafstrom, R C -- Fornace, A J Jr -- Autrup, H -- Lechner, J F -- Harris, C C -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):216-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828890" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bronchi/*cytology/drug effects ; Cells, Cultured ; *DNA/biosynthesis ; DNA Repair/*drug effects ; Epithelium/drug effects ; Fibroblasts/drug effects ; Formaldehyde/*pharmacology ; Humans
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Neuron-glia adhesion is inhibited by antibodies to neural determinants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-07
    Beschreibung: Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grumet, M -- Rutishauser, U -- Edelman, G M -- AI-11378/AI/NIAID NIH HHS/ -- HD-09635/HD/NICHD NIH HHS/ -- HD-16550/HD/NICHD NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Oct 7;222(4619):60-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194561" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal ; Antigen-Antibody Complex ; *Cell Adhesion ; Cell Membrane/immunology ; Cells, Cultured ; Chick Embryo ; Epitopes ; Immunoglobulin Fab Fragments ; Neuroglia/*physiology ; Neurons/immunology/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Tumor-derived growth factor increases bone resorption in a tumor associated with humoral hypercalcemia of malignancy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbing factor with the chemical characteristics of a tumor-derived transforming growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ibbotson, K J -- D'Souza, S M -- Ng, K W -- Osborne, C K -- Niall, M -- Martin, T J -- Mundy, G R -- AM-28149/AM/NIADDK NIH HHS/ -- CA-29537/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1292-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6577602" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Bone Resorption ; Calcium ; Cells, Cultured ; Culture Media ; Growth Substances/*physiology ; Hypercalcemia/*etiology ; Leydig Cell Tumor/complications/*physiopathology ; Male ; Neoplasm Proteins/*physiology ; Neoplasms, Experimental/complications/physiopathology ; Peptides/*physiology ; Rats ; Transforming Growth Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-01
    Beschreibung: The tissue culture condition that is required for the type of chromosome breakage seen at most fragile sites, namely, the absence of folic acid and thymidine in the medium, greatly enhanced micronucleus formation in proliferating lymphocyte cultures from normal individuals. This suggests that chromosome breakage at fragile sites and the apparently spontaneous damage that gives rise to micronuclei are controlled by the same mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jacky, P B -- Beek, B -- Sutherland, G R -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):69-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828880" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Cell Nucleus/drug effects/ultrastructure ; Cells, Cultured ; Child ; *Chromosome Aberrations ; Chromosome Fragile Sites ; *Chromosome Fragility ; Culture Media ; Dose-Response Relationship, Drug ; Female ; Folic Acid/pharmacology ; Humans ; Lymphocytes/ultrastructure ; Male ; Middle Aged ; Thymidine/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis. Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Magrath, I -- Erikson, J -- Whang-Peng, J -- Sieverts, H -- Armstrong, G -- Benjamin, D -- Triche, T -- Alabaster, O -- Croce, C M -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1094-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316501" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/complications ; Antigens, Viral/analysis ; Burkitt Lymphoma/complications/*genetics ; Cell Line ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Epstein-Barr Virus Nuclear Antigens ; Herpesvirus 4, Human/analysis ; Homosexuality ; Humans ; Immunoglobulin Light Chains/*biosynthesis ; Immunoglobulin kappa-Chains/*biosynthesis ; Male ; Oncogenes
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 11
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    Oxygen tension regulates the expression of angiogenesis factor by macrophages (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knighton, D R -- Hunt, T K -- Scheuenstuhl, H -- Halliday, B J -- Werb, Z -- Banda, M J -- GM27345/GM/NIGMS NIH HHS/ -- HL26323/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1283-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612342" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Angiogenesis Inducing Agents/*biosynthesis ; Animals ; Anoxia/physiopathology ; Cells, Cultured ; Cornea ; Growth Substances/*biosynthesis ; Macrophages/*physiology ; Models, Biological ; Oxygen/*physiology ; Rabbits ; *Wound Healing
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 12
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    Drug-induced alterations of cytokeratin organization in cultured epithelial cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-04
    Beschreibung: The distribution of keratin intermediate filaments, previously considered static in organization and imperturbable by conventional drugs used to alter the structure and organization of the cytoskeleton, can be altered significantly by treatment with colchicine and cytochalasin D. The loss of microfilaments and microtubules converts the keratin cytoskeleton from a branching, even distribution to a series of starlike structures whose filaments are maintained by multiple membrane attachment sites. These findings provide a means for manipulating cytokeratin organization to investigate the role of keratins in cytoskeletal structure and function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knapp, L W -- O'Guin, W M -- Sawyer, R H -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186022" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Colchicine/*pharmacology ; Cytochalasin D ; Cytochalasins/*pharmacology ; Cytoskeleton/*drug effects ; Epithelium ; *Keratins ; Mice ; Microtubules/drug effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 13
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    Human endothelial cells: use of heparin in cloning and long-term serial cultivation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-11
    Beschreibung: Endothelial cells from human blood vessels were cultured in vitro, with doubling times of 17 to 21 hours for 42 to 79 population doublings. Cloned human endothelial cell strains were established for the first time and had similar proliferative capacities. This vigorous cell growth was achieved by addition of heparin to culture medium containing reduced concentrations of endothelial cell growth factor. The routine cloning and long-term culture of human endothelial cells will facilitate studying the human endothelium in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, S C -- Mueller, S N -- Levine, E M -- AG-00839/AG/NIA NIH HHS/ -- T32-CA-09171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):623-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635659" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Division/drug effects ; Cells, Cultured ; Clone Cells/enzymology ; Endothelium/*cytology ; Growth Substances/pharmacology ; Heparin/*pharmacology ; Humans ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 14
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    Interaction with membrane remnants of target myotubes maintains transmitter sensitivity of cultured neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-27
    Beschreibung: Parasympathetic neurons, when cultured alone, lose sensitivity to acetylcholine, but if striated muscle is included in the culture, neuronal chemosensitivity is maintained. The membrane remnants of myotubes ruptured by osmotic shock also supported the responsiveness of the cultured neurons to transmitter, whereas muscle-conditioned medium or membrane remnants of nonmuscle embryonic skin cells did not support this responsiveness. The regulation of chemosensitivity by contact of neurons with the target cell membrane may be important in the formation and maintenance of neuronal circuitry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tuttle, J B -- NS-10338/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 27;220(4600):977-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6133352" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/physiology ; Animals ; Cell Membrane/physiology ; Cells, Cultured ; Chick Embryo ; Fibroblasts/physiology ; Muscles/*physiology ; Nervous System/growth & development ; Neurons/*physiology ; Neurotransmitter Agents/*physiology ; Synapses/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 15
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-03
    Beschreibung: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 16
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    High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-28
    Beschreibung: A protoplast fusion method was developed to stably transfect human cells with pSV2-derived plasmids at frequencies greater than 10(-3). This procedure made it possible to test the biological effect of a hepatitis B virus (HBV) gene independent of the viral structures required for infection. A pSV2gpt+ plasmid constructed to carry a subgenomic fragment of HBV that contained the core antigen gene (HBc gene) was transfected into human cells. A human epithelial cell line was stably transfected with the HBc+ gene by selecting recipient cells for expression of guanine phosphoribosyl transferase expression. With this gpt+/HBc+ cell line it was shown that growth in serum-free medium or treatment with 5'-azacytidine stimulates the production of the HBV core antigen. A hepatocellular carcinoma carrying the entire HBV genome was stimulated to produce the HBc gene product in response to the same factors that stimulated HBcAg production in the gpt+/HBc+ cell line constructed by transfection. The temporal relation between the cytopathologic response and HBc gene expression was similar for both cell types, indicating a primary role for HBc gene expression in the cytopathology of HBV-infected human liver.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yoakum, G H -- Korba, B E -- Lechner, J F -- Tokiwa, T -- Gazdar, A F -- Seeley, T -- Siegel, M -- Leeman, L -- Autrup, H -- Harris, C C -- New York, N.Y. -- Science. 1983 Oct 28;222(4622):385-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194563" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Azacitidine/pharmacology ; Cell Fusion ; *Cell Transformation, Viral ; Cells, Cultured ; Cytopathogenic Effect, Viral ; Gene Expression Regulation/drug effects ; Genes, Viral ; Hepatitis B Core Antigens/*genetics ; Humans ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 17
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    Insulin receptor: evidence that it is a protein kinase (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-21
    Beschreibung: Highly purified preparations of insulin receptor catalyzed the phosphorylation of the 95,000-dalton subunit of the insulin receptor. This subunit of the insulin receptor was also labeled with [alpha-32P]8-azidoadenosine 5'-triphosphate, a photoaffinity label for adenosine triphosphate binding sites. The identity of the 95,000-dalton band was confirmed in both cases by precipitation with a monoclonal antibody to the insulin receptor. These results suggest that the insulin receptor is itself a protein kinase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, R A -- Cassell, D J -- New York, N.Y. -- Science. 1983 Jan 21;219(4582):299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849137" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Cell Line ; Cells, Cultured ; Lymphocytes ; Molecular Weight ; Phosphoproteins/physiology ; Protein Kinases/*physiology ; Receptor, Insulin/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 18
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    Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-07-08
    Beschreibung: Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates with the 55-kilodalton glycoprotein D of herpes simplex virus type 1 and neutralizes the infectivity of herpes simplex viruses 1 and 2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seigneurin, J M -- Desgranges, C -- Seigneurin, D -- Paire, J -- Renversez, J C -- Jacquemont, B -- Micouin, C -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304881" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Antibodies, Monoclonal/*immunology ; B-Lymphocytes/immunology ; Bone Marrow/*immunology ; Bone Marrow Cells ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/immunology ; Simplexvirus/*immunology ; Viral Envelope Proteins ; Viral Proteins/*immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 19
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    Recombination during gene transfer into mouse cells can restore the function of deleted genes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-14
    Beschreibung: Two plasmids containing nonoverlapping deletions of the herpes simplex virus thymidine kinase gene were introduced into thymidine kinase-deficient mouse L cells by DNA-mediated gene transfer. Thymidine kinase-producing transformants were generated by a mixture of the two plasmids at a frequency significantly greater than that generated by either plasmid alone. Southern blot analyses demonstrated that functional thymidine kinase genes were generated by homologous recombination between the two deletion mutants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Small, J -- Scangos, G -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6294829" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cells, Cultured ; Chromosome Deletion ; *Genetic Engineering ; Mice ; Mutation ; *Plasmids ; *Recombination, Genetic ; Simplexvirus ; Thymidine Kinase/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 20
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    Bovine x mouse hybridomas that secrete bovine immunoglobulin G1 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. One of these lines has continued to secrete immunoglobulin G1 (5 to 10 micrograms per milliliter) for over 16 months. The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Srikumaran, S -- Guidry, A J -- Goldsby, R A -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):522-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6403985" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/biosynthesis ; Cattle ; Cell Line ; Hybridomas/*immunology ; Immunoglobulin G/*biosynthesis/immunology/isolation & purification ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Light Chains/immunology ; Immunoglobulin M/immunology ; Mice ; Radioimmunoassay
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 21
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    Serological visualization of interleukin 2 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: Interleukin 2, a lymphokine that acts as a second signal of cellular immune response by way of its action as a T-cell growth factor, was morphologically identified by immunoperoxidase staining. With the use of a monoclonal antibody to interleukin 2 and several complex-forming antisera, the lymphokine was readily distinguished in cytocentrifuge preparations of peripheral blood leukocytes stimulated with a T-cell mitogen. When preparations of cloned interleukin 2 producer and responder cells were stained by the same procedures, discrete patterns of both responder and producer cell phenotypes were revealed. Interleukin 2 producer T cells exhibited a characteristic intense, ringlike cytoplasmic staining, whereas the responder cells (as exemplified by interleukin 2-dependent cell lines) exhibited a less intensive, spotlike membrane staining. In addition, intense membrane localization of interleukin 2, reminiscent of potential capping phenomena, could be observed in stained preparations of cloned responder cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinmann, G -- Conlon, P -- Hefeneider, S -- Gillis, S -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6344215" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/immunology ; Cell Line ; Humans ; Immunoenzyme Techniques ; Interleukin-2/*physiology ; Leukocytes/physiology ; Mice ; T-Lymphocytes/physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 22
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    Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-26
    Beschreibung: Macrophages isolated from tumor-bearing patients as well as cultured human monocytes express Fc receptors that cross-react strongly with murine immunoglobulins of the G2a but only slightly or not at all with the G1, G2b, or G3 subclasses. Such macrophages in the presence of murine immunoglobulin G2a monoclonal antibodies to tumors mediated the killing of tumor cells in vitro. These data suggest that monoclonal antibodies of the G2a subclass may be useful in the immunotherapy of human cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steplewski, Z -- Lubeck, M D -- Koprowski, H -- CA-10815/CA/NCI NIH HHS/ -- CA-21124/CA/NCI NIH HHS/ -- CA-25874/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):865-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879183" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/*immunology ; Cells, Cultured ; Cytotoxicity, Immunologic ; Humans ; *Immunity, Cellular ; Immunoglobulin G/immunology ; Immunotherapy ; Macrophages/*immunology ; Mice ; Monocytes/immunology ; Neoplasms, Experimental/immunology/therapy ; Receptors, Fc/*immunology ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 23
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    Hepatitis B virus infection in cultured human lymphoblastoid cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-12
    Beschreibung: Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Romet-Lemonne, J L -- McLane, M F -- Elfassi, E -- Haseltine, W A -- Azocar, J -- Essex, M -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):667-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867736" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cells, Cultured ; Hepatitis B/*microbiology/pathology ; Hepatitis B Surface Antigens/immunology ; Hepatitis B virus/growth & development ; Humans ; Liver/pathology ; Lymphocytes/*microbiology/pathology ; Male ; Middle Aged
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 24
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    Synaptic activity mediates death of hypoxic neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: Cultured hippocampal neurons, when exposed to cyanide or an anoxic atmosphere in the early stages of differentiation, were not visibly affected. However, neurons in the mature cultures died when exposed to cyanide or anoxia. Cell death could be prevented by treatment with magnesium, which eliminates synaptic activity. These observations suggest that damage in hypoxic neurons is mediated by synaptic activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rothman, S M -- 5 K07 N500568-02/PHS HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):536-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836300" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials/drug effects ; Animals ; Anoxia/*metabolism/physiopathology ; Cells, Cultured ; Hippocampus/cytology ; Magnesium/pharmacology ; Magnesium Chloride ; Membrane Potentials/drug effects ; Neurons/metabolism/*physiology ; Rats ; Sodium Cyanide/pharmacology ; Synapses/drug effects/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 25
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    Infection of normal human epithelial cells by Epstein-Barr virus (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-11
    Beschreibung: Primary cultures of epithelial cells were grown from the tonsils and adenoids of patients with diseases not related to Epstein-Barr virus. The cells could not be infected by Epstein-Barr virus. Fluorescein-labeled Epstein-Barr virus and a cytofluorograph were then used to show that the epithelial cells do not have detectable receptors for the virus. However, implantation with Epstein-Barr virus receptors gave the cells the ability to bind the labeled virus. One to 5 percent of receptor-implanted cells exposed to the transforming B95-8 substrain of the virus expressed Epstein-Barr nuclear antigen. The early and viral capsid Epstein-Barr virus-determined antigens were not detected in the virus-infected cultures. The results show that normal human epithelial cells from the nasopharynx become susceptible to infection by Epstein-Barr virus when the membrane barrier resulting from the lack of viral receptors is overcome by receptor implantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, I M -- Volsky, D J -- 1R01 CA33386-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 11;219(4589):1225-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298935" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cells, Cultured ; Epithelium/*microbiology ; Herpesviridae Infections/*microbiology ; Herpesvirus 4, Human/growth & development ; Humans ; Receptors, Virus/metabolism ; Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 26
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    Bromine residue at hydrophilic region influences biological activity of aplysiatoxin, a tumor promoter (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    Axonal proteins of presynaptic neurons during synaptogenesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: Changes occur in the synthesis and axonal transport of neuronal proteins in dorsal-root ganglia axons as a result of contact with cells from the spinal cord during synapse formation. Dorsal-root ganglia cells were cultured in a compartmental cel culture system that allows separate access to neuronal cell bodies and their axons. When cells from the ventral spinal cord were cultured with the dorsal-root ganglia axons, synapses were established within a few days. Metabolic labeling and two-dimensional electrophoresis revealed that four of more than 300 axonal proteins had changed in their expression by the time synapses were established. The highly selective nature of these changes suggests that the proteins involved may be important in the processes of axon growth and synapse formation and their regulation by the regional environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonderegger, P -- Fishman, M C -- Bokoum, M -- Bauer, H C -- Nelson, P G -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1294-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612344" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Axons/*metabolism ; Cells, Cultured ; Chick Embryo ; Isoelectric Point ; Molecular Weight ; Nerve Tissue Proteins/*biosynthesis ; Synapses/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-04
    Beschreibung: Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spector, I -- Shochet, N R -- Kashman, Y -- Groweiss, A -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):493-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6681676" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Actins/metabolism ; Animals ; *Bicyclo Compounds, Heterocyclic ; Cells, Cultured ; Cytoskeleton/*drug effects ; Fibroblasts/ultrastructure ; Marine Toxins/*pharmacology ; Microscopy, Fluorescence ; Microtubules/drug effects ; Neuroblastoma/ultrastructure ; Thiazoles/*pharmacology ; Thiazolidines
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: The involvement of plasma fibronectin in phagocytosis of bacteria was investigated by testing the binding of fibronectin to several species of bacteria and by evaluating the ability of fibronectin to promote binding and endocytosis of two species of these bacteria by phagocytic cells. Fibronectin binds non-covalently to Gram-positive and Gram-negative bacteria and to yeast but did not appear to be necessary or sufficient for uptake of Staphylococcus aureus and Salmonella typhimurium by several different phagocytic cell types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van de Water, L -- Destree, A T -- Hynes, R O -- R01CA17007/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338594" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacteria/*metabolism ; Cell Line ; Cricetinae ; Endocytosis ; Fibronectins/*metabolism ; Humans ; Macrophages/physiology ; Mice ; Opsonin Proteins/physiology ; *Phagocytosis ; Rabbits ; Salmonella typhimurium/metabolism ; Sepsis/immunology ; Staphylococcus aureus/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 30
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    Glucose stimulation of the antilipolytic effect of insulin in humans (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-03
    Beschreibung: Dose-response studies of the inhibition of lipolysis by insulin in isolated human adipocytes were conducted with the use of a sensitive bioluminescent assay of glycerol release. The addition of glucose to the incubation medium was associated with an increase in insulin sensitivity and an increase in the maximum insulin effect. The results suggest that glucose plays an important role in regulating the antilipolytic action of insulin in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arner, P -- Bolinder, J -- Ostman, J -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1057-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6342138" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipose Tissue/cytology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Synergism ; Glucose/*pharmacology ; Humans ; Insulin/*pharmacology ; Isoproterenol/pharmacology ; Lipolysis/*drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 31
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    Selective reduction of forskolin-stimulated cyclic AMP accumulation by inhibitors of protein synthesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: Inhibiting protein synthesis by incubating C6-2B rat astrocytoma cells with cycloheximide or emetine for periods up to 24 hours caused a progressive decrease in the accumulation of adenosine 3',5'-monophosphate (cyclic AMP) when the cells were challenged for 30 minutes with 100 microM forskolin. In contrast, cholera toxin-stimulated (6 nM, 3 hours) cyclic AMP accumulation was not diminished in cycloheximide-treated cells, and cyclic AMP was only minimally diminished in response to a 30-minute challenge with 10 microM (-)-isoproterenol. These experiments suggest the presence of a previously unrecognized cyclase component, which is essential for forskolin-stimulated cyclic AMP accumulation and has a shorter half-life than the beta-adrenergic receptor, the guanine nucleotide regulatory proteins, or the cyclase catalytic component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooker, G -- Pedone, C -- Barovsky, K -- HL 06330/HL/NHLBI NIH HHS/ -- HL 28940/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1169-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6190226" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Astrocytoma/metabolism ; Cell Line ; Cholera Toxin/pharmacology ; Colforsin ; Cyclic AMP/*biosynthesis/physiology ; Cycloheximide/pharmacology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Diterpenes/*pharmacology ; Emetine/pharmacology ; Isoproterenol/pharmacology ; *Protein Biosynthesis ; RNA/biosynthesis ; Rats
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 32
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    Ethanol modulation of opiate receptors in cultured neural cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-16
    Beschreibung: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 33
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    Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-27
    Beschreibung: The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eva, A -- Aaronson, S A -- New York, N.Y. -- Science. 1983 May 27;220(4600):955-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6302839" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; DNA Restriction Enzymes ; DNA, Neoplasm/genetics ; Fibrosarcoma/chemically induced/*genetics ; Humans ; Methylcholanthrene/*pharmacology ; Mice ; Oncogenes/*drug effects ; Retroviridae/genetics ; Transfection
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 34
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    Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-21
    Beschreibung: Fluoride is one of the most potent but least well understood stimulators of bone formation in vivo. Bone formation was shown to arise from direct effects on bone cells. Treatment with sodium fluoride increased proliferation and alkaline phosphatase activity of bone cells in vitro and increased bone formation in embryonic calvaria at concentrations that stimulate bone formation in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farley, J R -- Wergedal, J E -- Baylink, D J -- AM31061/AM/NIADDK NIH HHS/ -- AM31062/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 21;222(4621):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623079" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkaline Phosphatase/*metabolism ; Animals ; Bone Development/*drug effects ; Bone and Bones/*cytology/embryology/enzymology ; Cell Division/drug effects ; Cells, Cultured ; Chick Embryo ; Dose-Response Relationship, Drug ; Fluorides/*pharmacology ; Parathyroid Hormone/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 35
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    Shark cartilage contains inhibitors of tumor angiogenesis (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: Shark cartilage contains a substance that strongly inhibits the growth of new blood vessels toward solid tumors, thereby restricting tumor growth. The abundance of this factor in shark cartilage, in contrast to cartilage from mammalian sources, may make sharks an ideal source of the inhibitor and may help to explain the rarity of neoplasms in these animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, A -- Langer, R -- EY04002/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1185-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6193581" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cartilage/*physiology ; Cell Line ; Cornea ; Neoplasms/*blood supply ; *Neovascularization, Pathologic ; Rabbits ; Sharks
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 36
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    Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kartner, N -- Riordan, J R -- Ling, V -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1285-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6137059" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cell Membrane Permeability ; *Drug Resistance ; Glycoproteins/immunology/*physiology ; Membrane Proteins/*physiology ; Molecular Weight ; P-Glycoprotein
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 37
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    Cell growth on liquid microcarriers (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-25
    Beschreibung: Anchorage-dependent cell growth is demonstrated on microcarriers of fluorocarbon fluid formed by emulsification and stabilized with polylysine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keese, C R -- Giaever, I -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1448-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828872" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Adhesion ; Cell Division ; *Cell Physiological Phenomena ; Cells, Cultured ; Culture Media ; Emulsions ; Fluorocarbons ; Kinetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 38
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    Substance P and somatostatin regulate sympathetic noradrenergic function (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-09
    Beschreibung: Peptidergic-noradrenergic interactions were examined in explants of rat sympathetic superior cervical ganglia and in cultures of dissociated cells. The putative peptide transmitters substance P and somatostatin each increased the activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase after 1 week of exposure in culture. Maximal increases occurred at 10(-7) molar for each peptide, and either increasing or decreasing the concentration reduced the effects. Similar increases in tyrosine hydroxylase were produced by a metabolically stable agonist of substance P, while a substance P antagonist prevented the effects of the agonist. The data suggest that the increased tyrosine hydroxylase activity was mediated by peptide interaction with specific substance P receptors and that peptides may modulate sympathetic catecholaminergic function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kessler, J A -- Adler, J E -- Black, I B -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1059-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6192502" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bacitracin/pharmacology ; Captopril/pharmacology ; Cells, Cultured ; Culture Techniques ; Dose-Response Relationship, Drug ; Ganglia, Sympathetic/*enzymology ; Rats ; Somatostatin/*pharmacology ; Substance P/*pharmacology ; Tyrosine 3-Monooxygenase/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
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    Action potentials in macrophages derived from human monocytes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-25
    Beschreibung: The electrical activity of macrophages derived from human blood monocytes was recorded in vitro with intracellular microelectrodes and was analyzed with computer-assisted data acquisition and analysis techniques. In cells impaled 6 to 8 days after the cultures were prepared, the resting potentials reached a maximum value of -72 millivolts. The cells were electrically excitable; spikes exhibited a slow upstroke, a fast downstroke, a discrete threshold, a large overshoot, and a brief undershoot. Repetitive firing was induced by a maintained depolarizing current. A positive relation was observed between transmembrane currents and resting potential. Voltage-current relations were nonrectifying for subthreshold current injections. Since these cells had not been treated with any specific activation factors, the electrical activity recorded is evidence for the presence of voltage-dependent inward and outward currents in the membranes of mature macrophages. The electrical signals generated by these cells may be useful for the assay of sensor and effector functions of macrophages, such as chemotaxis, receptor-ligand interactions, and phagocytosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCann, F V -- Cole, J J -- Guyre, P M -- Russell, J A -- AM0535/AM/NIADDK NIH HHS/ -- BRSG05392/RS/DRS NIH HHS/ -- CA17323/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Feb 25;219(4587):991-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6823563" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Cell Differentiation ; Cells, Cultured ; Humans ; Macrophages/*physiology ; Monocytes/cytology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 40
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    Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-04
    Beschreibung: The gene for glycoprotein D of herpes simplex virus type 1 (HSV-1) was expressed in stable mammalian cell lines. Glycoprotein D produced in these cells has a number of antigenic determinants in common with the native glycoprotein. Cell lines expressing glycoprotein D were used in an enzyme-linked immunosorbent assay to detect human antibodies to glycoprotein D. This strategy should prove useful in determining the extent to which the immune response to HSV-1 is directed toward glycoprotein D.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berman, P W -- Dowbenko, D -- Lasky, L A -- Simonsen, C C -- New York, N.Y. -- Science. 1983 Nov 4;222(4623):524-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6312563" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Viral/*analysis ; Base Sequence ; Cell Line ; Clone Cells ; DNA Restriction Enzymes ; DNA, Viral/genetics ; Enzyme-Linked Immunosorbent Assay ; *Genes ; *Genes, Viral ; Humans ; Plasmids ; Simplexvirus/genetics/*immunology ; Tetrahydrofolate Dehydrogenase/genetics ; *Viral Envelope Proteins ; Viral Proteins/*genetics/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
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    Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-14
    Beschreibung: Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- McIsaac, R M -- Chen, L B -- CA22427/CA/NCI NIH HHS/ -- CA29793/CA/NCI NIH HHS/ -- CA33847/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):169-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623064" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinoma/*drug therapy ; Carcinoma, Ehrlich Tumor/*drug therapy ; Cell Line ; Deoxyglucose/therapeutic use ; Drug Synergism ; Drug Therapy, Combination ; Energy Metabolism/drug effects ; Mice ; Mitochondria/drug effects ; Rhodamine 123 ; Rhodamines/*therapeutic use ; Urinary Bladder Neoplasms/*drug therapy ; Xanthenes/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 42
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    Transcriptional regulation of globin gene expression in the human erythroid cell line K562 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-17
    Beschreibung: The effect of hemin on the rate of synthesis and the level of globin messenger RNA's in the human erythroid cell line K562 was examined by means of cloned hybridization probes specific for each of the human embryonic, fetal, and adult globin genes. Hemin increases both the rate of transcription and the level of accumulation of zeta-, epsilon-, gamma-, and alpha-globin messenger RNA's by a factor of 3 to 5. Thus, hemin induction of globin gene expression in K562 cells is at the level of transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charnay, P -- Maniatis, T -- HL278989/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 17;220(4603):1281-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574602" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Erythroblasts/*metabolism ; Erythrocytes/*metabolism ; *Gene Expression Regulation/drug effects ; Globins/*genetics ; Hemin/pharmacology ; Humans ; Leukemia, Myeloid/metabolism ; RNA, Messenger/biosynthesis/genetics ; *Transcription, Genetic/drug effects
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 43
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    Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Human T-cell leukemia virus (HTLV), American PL isolate, was transmitted by cocultivation and by cell-free filtrates to a nonlymphoid human osteogenic sarcoma (HOS) cell line, designated HOS/PL, but not to nine other lines bearing receptors for HTLV. HOS and HOS/PL cells are not dependent on interleukin-2 and do not express interleukin-2 receptors that are recognized by anti-Tac monoclonal antibody. HTLV released by the Japanese MT2 cell line was also transmitted to HOS cells. The infected HOS cells release substantial titers of progeny HTLV which is antigenically indistinguishable from parental virus and is able to transform T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clapham, P -- Nagy, K -- Cheingsong-Popov, R -- Exley, M -- Weiss, R A -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1125-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316502" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigens, Surface/analysis ; Antigens, Viral/analysis ; Cell Line ; Cell Transformation, Viral ; Cell-Free System ; Deltaretrovirus/*growth & development/immunology/ultrastructure ; Humans ; Interleukin-2/metabolism ; Microscopy, Electron ; T-Lymphocytes/immunology ; *Virus Replication
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 44
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    Cooperation between oncogenes. Investigators focus on cooperation between two or more oncogenes to help explain the multistep development of human cancers (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-11
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):602-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635658" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Cycle ; Cells, Cultured ; Mice ; *Oncogenes ; Platelet-Derived Growth Factor/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 45
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    Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-06
    Beschreibung: After transport in the blood and implantation in the microcirculation, metastatic tumor cells must invade the vascular endothelium and underlying basal lamina. Mouse B16 melanoma sublines were used to determine the relation between metastatic properties and the ability of the sublines to degrade enzymatically the sulfated glycosaminoglycans present in the extracellular matrix of cultured vascular endothelial cells. Highly invasive and metastatic B16 sublines degraded matrix glycosaminoglycans faster than did sublines of lower metastatic potential. The main products of this matrix degradation were heparan sulfate fragments. Intact B16 cells (or their cell-free homogenates) with a high potential for lung colonization degraded purified heparan sulfate from bovine lung at higher rates than did B16 cells with a poor potential for lung colonization. Analysis of the degradation fragments indicated that B16 cells have a heparan sulfate endoglycosidase. Thus the abilities of B16 melanoma cells to extravasate and successfully colonize the lung may be related to their capacities to degrade heparan sulfate in the walls of pulmonary blood vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakajima, M -- Irimura, T -- Di Ferrante, D -- Di Ferrante, N -- Nicolson, G L -- R01-AM-26482/AM/NIADDK NIH HHS/ -- R01-CA-28867/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):611-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6220468" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Glycosaminoglycans/*metabolism ; Glycoside Hydrolases/metabolism ; Heparitin Sulfate/*metabolism ; Melanoma/enzymology/*physiopathology ; Mice ; *Neoplasm Invasiveness ; *Neoplasm Metastasis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 46
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    RNA splice site selection: evidence for a 5' leads to 3' scanning model (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Human G gamma-globin genes containing tandem duplications of the donor (5') or acceptor (3') RNA splice sites of the second intervening sequence were constructed in order to ascertain the directionality of RNA splice site selection. These genes were introduced into cultured monkey cells, and their transcripts were analyzed. Transcripts of these duplication variants were spliced only at the proximal copy of the duplicated splice sites. These data are consistent with a 5' leads to 3' model of splice site selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lang, K M -- Spritz, R A -- AM28598/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1351-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304877" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Base Sequence ; Cells, Cultured ; Globins/genetics ; Haplorhini ; Humans ; Plasmids ; *RNA Splicing ; RNA, Messenger/genetics/physiology ; Simian virus 40/genetics ; Transcription, Genetic
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 47
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    Vasoactive intestinal peptide alters membrane potential and cyclic nucleotide levels in retinal horizontal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-09
    Beschreibung: Vasoactive intestinal peptide stimulated the synthesis of adenosine 3',5'-monophosphate in fractions of isolated carp horizontal cells. When applied extracellularly to isolated and cultured horizontal cells, the peptide also induced a slow depolarization (30 to 40 millivolts) accompanied by a decrease in membrane resistance. However, analogs of adenosine 3',5'-monophosphate applied extracellularly or intracellularly, and forscolin applied extracellularly, had no effect on the membrane potential of cultured horizontal cells, indicating that the induced depolarization was not related to the accumulation of adenosine 3',5'-monophosphate in these cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lasater, E M -- Watling, K J -- Dowling, J E -- EY-00811/EY/NEI NIH HHS/ -- EY-00824/EY/NEI NIH HHS/ -- EY-05476/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1070-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308770" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carps ; Cells, Cultured ; Cyclic AMP/*metabolism ; Dopamine/pharmacology ; Gastrointestinal Hormones/*pharmacology ; Kainic Acid/pharmacology ; Membrane Potentials/*drug effects ; Retina/*drug effects/physiology ; Vasoactive Intestinal Peptide/*pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 48
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    A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-29
    Beschreibung: The antigen defined by a rat monoclonal antibody directed to a Burkitt lymphoma cell line was identified as globotriaosylceramide [Gal alpha (1 leads to 4)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide]. The antibody demonstrated a strict steric specificity since it did not react with globoisotriaosylceramide [Gal alpha (1 leads to 3)-Gal beta (1 leads to 4)-Glc beta (1 leads to 1)-ceramide], the positional isomer of the antigen associated with the Burkitt lymphoma. Chemical analysis of various Burkitt lymphoma cell lines revealed that the Burkitt lymphoma cells contained more than 100 times as much of the glycolipid antigen as was found in other human lymphoma and leukemia cell lines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nudelman, E -- Kannagi, R -- Hakomori, S -- Parsons, M -- Lipinski, M -- Wiels, J -- Fellous, M -- Tursz, T -- CA 19224/CA/NCI NIH HHS/ -- CA 20026/CA/NCI NIH HHS/ -- GM 23100/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal/*immunology ; Antigens, Neoplasm/*immunology ; Burkitt Lymphoma/*immunology ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Erythrocytes/immunology ; Globosides/*immunology ; Glycosphingolipids/*immunology ; Humans ; Rabbits ; Rats ; *Trihexosylceramides
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 49
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    Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal lambda II protein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional lambda I protein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both lambda II- and lambda I-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent lambda isotypes may be coordinately regulated in immunoglobulin-secreting cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Milburn, G L -- Lynch, R G -- Granner, D K -- AM25295/AM/NIADDK NIH HHS/ -- CA28848/CA/NCI NIH HHS/ -- CA32275/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1389-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6222474" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; *Gene Expression Regulation ; Immunoglobulin Light Chains/genetics ; Immunoglobulin lambda-Chains/genetics ; Immunoglobulins/*genetics ; Mice ; Mice, Inbred BALB C ; Plasmacytoma/genetics/immunology ; RNA, Messenger/biosynthesis ; T-Lymphocytes, Regulatory/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 50
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    Evidence for the recessive nature of cellular immortality (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-02
    Beschreibung: Fusion of immortal cell lines with normal human fibroblasts or certain other immortal cell lines yields hybrids having limited division potential. Cellular immortality was found to be a recessive phenotype in hybrids. It was also found that at least two separate events in the normal cell genome can result in immortality. In fusions involving certain immortal parent cells, these events can be complemented to result in hybrids with finite division capacity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pereira-Smith, O M -- Smith, J R -- AG 03262/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):964-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879195" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Cell Division ; Cell Line ; *Cell Survival ; Cells, Cultured ; Genes, Recessive ; Humans ; Hybrid Cells/*physiology ; Phenotype
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 51
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    Activation of 2-aminofluorene by cultured plant cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-03-25
    Beschreibung: Cultured tobacco plant cells activated 2-aminofluorene to an agent mutagenic to Salmonella typhimurium strain TA98. The plant activation of 2-aminofluorene is heat-inactivated and may not involve solely cytochrome P-450. The kinetics of activation demonstrated both time- and concentration-dependent responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plewa, M J -- Weaver, D L -- Blair, L C -- Gentile, J M -- ES02384/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 25;219(4591):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6338591" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biotransformation ; Cells, Cultured ; Fluorenes/*metabolism/pharmacology ; Kinetics ; Mutagenicity Tests ; Mutagens/*metabolism ; *Mutation ; *Plants, Toxic ; Salmonella typhimurium/drug effects ; Tobacco/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 52
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    Isolation and transmission of human retrovirus (human t-cell leukemia virus) (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-18
    Beschreibung: Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popovic, M -- Sarin, P S -- Robert-Gurroff, M -- Kalyanaraman, V S -- Mann, D -- Minowada, J -- Gallo, R C -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):856-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6600519" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Cells, Cultured ; Female ; Humans ; Leukemia/*microbiology ; Male ; Retroviridae/growth & development/*isolation & purification ; T-Lymphocytes/*microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 53
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    Correlation of glucocorticoid receptor binding sites on MMTV proviral DNA with hormone inducible transcription (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-23
    Beschreibung: Steroid hormones, when complexed to their receptors, recognize and bind specific DNA sequences and subsequently induce increased levels of transcription. The mechanisms of steroid hormone action were analyzed by constructing chimeric DNA molecules from portions of mouse mammary tumor virus envelope and long terminal repeat (LTR) regions ligated to the thymidine kinase (tk) gene of herpes simplex virus. This construction allowed the tk gene to be expressed in a hormone-responsive fashion upon transfection into Ltk- cells. Comparison of transcription data with in vitro binding data showed that hormone-responsive transcription can be directly correlated to the presence of steroid hormone receptor binding sites on the DNA. There are at least two such receptor binding sites in the LTR region, one between -202 and -137 and another between -137 and -50 base pairs from the RNA cap site, as well as a site near the 5' end of the envelope region. These results strengthen the hypothesis that steroid-receptor complexes regulate genes primarily by binding to DNA sites near the promoter region and thereby modulate transcription.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfahl, M -- McGinnis, D -- Hendricks, M -- Groner, B -- Hynes, N E -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1341-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318311" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Binding Sites ; Cell Line ; Chimera ; DNA, Viral/*metabolism ; Glucocorticoids/metabolism/*pharmacology ; Mammary Tumor Virus, Mouse/*analysis ; Mice ; Receptors, Glucocorticoid/*metabolism ; Receptors, Steroid/*metabolism ; Repetitive Sequences, Nucleic Acid ; Transcription, Genetic/*drug effects ; Transfection ; Triamcinolone Acetonide/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 54
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    Mobilization of cellular calcium-45 and lead-210: effect of physiological stimuli (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Isolated rat hepatocytes in primary culture were used as a model system to evaluate the effects of selected hormones and culture conditions on the efflux of calcium-45 and lead-210 from cells labeled with these isotopes. Alpha-adrenergic stimuli, angiotensin, vasopressin, dibutyryl adenosine 3',5'-monophosphate, and reduced phosphate concentrations in the medium increased the efflux of calcium-45 and lead-210. Glucagon and insulin had no effect, but increased phosphate concentrations decreased the efflux of both isotopes. Experiments with hepatocytes cultured in a medium free of calcium and lead demonstrated that the increased efflux of calcium-45 and lead-210 induced by hormones was the result of mobilization of the ions from intracellular stores. The data indicate that the physiological stimuli that mobilized calcium ions also mobilized lead ions, and that the mobilized lead would be available to interact with calcium-mediated cell functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pounds, J G -- Mittelstaedt, R A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):308-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301003" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Angiotensin II/pharmacology ; Animals ; Bucladesine/pharmacology ; Calcium Radioisotopes/*metabolism ; Cells, Cultured ; Epinephrine/pharmacology ; Insulin/pharmacology ; Lead/*metabolism ; Liver/cytology ; Phosphates/pharmacology ; Propranolol/pharmacology ; Radioisotopes ; Rats ; Vasopressins/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 55
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    1,25-dihydroxyvitamin D3 receptors in human leukocytes (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-16
    Beschreibung: A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Provvedini, D M -- Tsoukas, C D -- Deftos, L J -- Manolagas, S C -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6310748" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): B-Lymphocytes/analysis ; Cell Line ; Humans ; Leukemia/analysis ; Leukocytes/*analysis ; Lymphocyte Activation ; Monocytes/analysis ; Receptors, Calcitriol ; Receptors, Steroid/*analysis ; T-Lymphocytes/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 56
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    Irreversible ligands with high selectivity toward delta and mu opiate receptors (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 57
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    Modulation of the metastatic capability in B16 melanoma by cell shape (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-23
    Beschreibung: The lung colonization of B16-F1 cells grown in flat and spherical configurations was studied. Cells cultivated in vitro as spheroids on a nonadhesive substrate expressed in a reversible fashion a marked increase in their propensity to establish metastases. The altered metastatic capability was accompanied by a reversible reduction in the accessibility of cell surface proteins to external iodination and by a dramatic decrease in the synthesis of vimentin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raz, A -- Ben-Ze'ev, A -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1307-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612347" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Adhesion ; Cell Division ; Cells, Cultured ; Intermediate Filament Proteins/biosynthesis ; Lung Neoplasms/secondary ; Melanoma/*pathology ; Membrane Proteins/physiology ; Mice ; *Neoplasm Metastasis ; Neoplasm Proteins/physiology ; Neoplasms, Experimental/pathology ; Vimentin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 58
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    Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-20
    Beschreibung: A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barre-Sinoussi, F -- Chermann, J C -- Rey, F -- Nugeyre, M T -- Chamaret, S -- Gruest, J -- Dauguet, C -- Axler-Blin, C -- Vezinet-Brun, F -- Rouzioux, C -- Rozenbaum, W -- Montagnier, L -- New York, N.Y. -- Science. 1983 May 20;220(4599):868-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6189183" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acquired Immunodeficiency Syndrome/*microbiology ; Adult ; Animals ; Antibodies, Viral/immunology ; Cells, Cultured ; Humans ; Male ; Microscopy, Electron ; RNA-Directed DNA Polymerase/metabolism ; Retroviridae/*isolation & purification ; T-Lymphocytes/microbiology ; Tumor Virus Infections/*microbiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 59
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    Regulation of the macrophage content of neoplasms by chemoattractants (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-08
    Beschreibung: Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bottazzi, B -- Polentarutti, N -- Acero, R -- Balsari, A -- Boraschi, D -- Ghezzi, P -- Salmona, M -- Mantovani, A -- R01 CA 12764/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 8;220(4593):210-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828888" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Chemotactic Factors/*physiology ; Humans ; Leukemia/immunology ; Lymphoma/immunology ; Macrophages/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Neoplasms/*immunology/physiopathology ; Neoplasms, Experimental/immunology ; Sarcoma/immunology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 60
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    Myasthenic globulin enhances the loss of acetylcholine receptor clusters (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-01-14
    Beschreibung: Acetylcholine receptors are present in the sarcolemma of cultured skeletal muscle myotubes either as large clusters or in a diffuse distribution. Both the clustered and diffuse acetylcholine receptors are potentially removable from the membrane. Treatment of myotubes with globulin from patients with myasthenia gravis causes the loss of acetylcholine receptor clusters and the concomitant appearance of acetylcholine receptor microaggregates. The rate of acetylcholine receptor cluster loss is greater than the rate of acetylcholine receptor degradation, indicating that acetylcholine receptors are disrupted from clusters to form microaggregates before being removed from the plasma membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bursztajn, S -- McManaman, J L -- Elias, S B -- Appel, S H -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849132" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Autoantibodies ; Cells, Cultured ; Humans ; Immunologic Capping ; Macromolecular Substances ; Membrane Proteins/metabolism ; Myasthenia Gravis/*immunology ; Pinocytosis ; Receptors, Cholinergic/immunology/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 61
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    Sodium currents in segments of human heart cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-15
    Beschreibung: Isolated human heart cells were partially drawn into the lumen of a plastic tube and cleaved at the partitioning tube wall by intraluminal suction pulses. The extraluminal segment (10 to 20 percent of the cell length) was suitable for intracellular perfusion and voltage clamp. The time and voltage dependence of the sodium current, and the responses to changes in driving force and channel blockers, illustrate the potential of these preparations as models for the study of membrane channels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bustamante, J O -- McDonald, T F -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301004" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cells, Cultured ; Humans ; Ion Channels/drug effects ; Lidocaine/pharmacology ; Membrane Potentials/drug effects ; Myocardium/*cytology/metabolism ; Sodium/*metabolism/physiology ; Tetrodotoxin/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 62
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    Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas: novel suppressor mechanism (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-05-13
    Beschreibung: Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat production is substantially enhanced by the interaction of glioma cells with a macromolecular factor released by human peripheral blood mononuclear cells in culture. This interaction thus constitutes an unusual mechanism by which inflammatory cells may nonspecifically suppress the cellular immune response to at least one class of solid tumors in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dick, S J -- Macchi, B -- Papazoglou, S -- Oldfield, E H -- Kornblith, P L -- Smith, B H -- Gately, M K -- New York, N.Y. -- Science. 1983 May 13;220(4598):739-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6220469" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; Cytotoxicity, Immunologic ; Glioma/immunology/*metabolism ; Glycosaminoglycans/biosynthesis ; Humans ; Hyaluronoglucosaminidase/metabolism ; Immunity, Cellular ; Lymphocytes/immunology/*metabolism ; Mice ; Rabbits
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 63
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    Mutation affecting the 12th amino acid of the c-Ha-ras oncogene product occurs infrequently in human cancer (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-10
    Beschreibung: A point mutation alters the 12th amino acid of the c-Ha-ras oncogene product p21 in a human bladder cancer cell line. This is, at present, the only mutation known to result in a human transforming gene. This mutation may therefore represent a possible target for mutagenesis leading to carcinogenesis in humans. By means of restriction enzyme analysis, 29 human cancers, including 20 primary tumor tissues, derived from organs commonly exposed to environmental carcinogens, were tested for the presence of this mutation. None of ten primary bladder carcinomas exhibited the mutation; nor did nine colon carcinomas or ten carcinomas of the lung. Thus the point mutation affecting the 12th amino acid of the c-Ha-ras gene product, while a valuable model for carcinogenesis, does not appear to play a role in the development of most human epithelial cancers of the bladder, colon, or lung.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feinberg, A P -- Vogelstein, B -- Droller, M J -- Baylin, S B -- Nelkin, B D -- 09071/PHS HHS/ -- 24592/PHS HHS/ -- 31053/PHS HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6304875" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenocarcinoma/genetics ; Carcinoma, Small Cell/genetics ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Transitional Cell/genetics ; Cell Line ; Cell Transformation, Neoplastic/metabolism ; Colonic Neoplasms/genetics ; Humans ; Lung Neoplasms/genetics ; *Mutation ; Neoplasm Proteins/*genetics ; *Oncogenes ; Proto-Oncogene Proteins p21(ras) ; Urinary Bladder Neoplasms/genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 64
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    Human brain tumor--derived cell lines: growth rate reduced by human fibroblast interferon (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-18
    Beschreibung: The biological response modifier human beta-interferon had pronounced antigrowth effects on various histologic types of human brain tumor cells but no effects on a nontransformed cell line, MRC-5. The cultures of brain tumor cells showed severe alterations indicative of cell injury and death after exposure to beta-interferon for 2 to 6 days. Similar results were obtained with cells freshly explanted from human brain tumors. The results indicate that it may be possible to use fresh, explanted tumor tissue to identify patients who might benefit from therapy with beta-interferon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, A W -- Carter, W A -- Nidzgorski, F -- Akhtar, L -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):881-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6401866" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Brain Neoplasms/pathology/*therapy ; Cell Division ; Cells, Cultured ; Humans ; Interferon-gamma/pharmacology/*therapeutic use
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 65
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    Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-04
    Beschreibung: The human cellular homolog of the transforming DNA sequence isolated from the bladder carcinoma cell line EJ was localized on the short arm of human chromosome 11 by Southern blot analysis of human-rodent hybrid cell DNA. This locus contains human sequences homologous to the Harvey murine sarcoma virus v-Ha-ras oncogene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Martinville, B -- Giacalone, J -- Shih, C -- Weinberg, R A -- Francke, U -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297001" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Line ; Chromosome Mapping ; *Chromosomes, Human, 6-12 and X ; DNA Restriction Enzymes ; Humans ; Hybrid Cells ; Nucleic Acid Hybridization ; *Oncogenes ; Urinary Bladder Neoplasms/*genetics
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 66
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    Tumor promotion by phorbol esters in skin: evidence for a memory effect (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-01
    Beschreibung: By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furstenberger, G -- Sorg, B -- Marks, F -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828884" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carcinogens/*pharmacology ; Cell Line ; Epidermis/drug effects ; Female ; Hyperplasia/chemically induced ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/chemically induced ; Phorbol Esters/*adverse effects ; Phorbols/*adverse effects ; Precancerous Conditions/chemically induced ; Skin Neoplasms/*chemically induced ; Tetradecanoylphorbol Acetate/*adverse effects ; Time Factors
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 67
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    Cell-to-cell transfer of interferon-induced antiproliferative activity (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-02
    Beschreibung: Interferon-treated cells rapidly and efficiently transferred the antiproliferative activity of interferon to untreated cells. This phenomenon was not due to the carry-over of interferon by the interferon-treated cells. Thus, to evoke an antiproliferative state, interferon did not directly contact each cell in a population. The results suggest a novel mechanism by which interferon may indirectly regulate cell growth, and suggests that cells other than those of the immune system may play a role in controlling tumor growth in tissue where cell-to-cell contact occurs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lloyd, R E -- Blalock, J E -- Stanton, G J -- 03348/PHS HHS/ -- AM 30046/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 2;221(4614):953-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6192500" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Cell Communication ; Cell Division/*drug effects ; Cells, Cultured ; Humans ; Interferons/*pharmacology ; Leukemia L1210 ; Mice ; Species Specificity
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 68
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    Serum factor supporting long-term survival of rat central neurons in culture (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: Gel filtration of serum at pH 3.6 yielded a fraction that supported long-term (months) survival of dissociated rat central neurons in monolayer culture more reliably than the traditionally used unfractionated serum. The cultures remained neuron-rich, because this fraction did not support the proliferation of glia and fibroblasts that occurs in whole serum. With an apparent molecular weight of 55,000 and an isoelectric point of 5.6, the active factor (or factors) in this fraction is distinct from any well-defined growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaufman, L M -- Barrett, J N -- NS07044/NS/NINDS NIH HHS/ -- NS12207/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1394-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857258" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; *Cell Survival/drug effects ; Cells, Cultured ; Chromatography, Gel ; Horses ; Isoelectric Focusing ; Molecular Weight ; Nerve Growth Factors/isolation & purification/*pharmacology ; Neurons/drug effects/*physiology ; Rats ; Rats, Inbred Strains ; Spinal Cord/cytology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 69
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    Clerics urge ban on altering germline cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-06-24
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Norman, C -- New York, N.Y. -- Science. 1983 Jun 24;220(4604):1360-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6574603" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Advisory Committees ; Cell Line ; *Ethics, Medical ; Federal Government ; Genetic Diseases, Inborn/therapy ; *Genetic Engineering ; *Germ Cells ; *Government Regulation ; Human Characteristics ; Humans ; Risk Assessment ; United States ; cells has been signed by leaders of almost every major church group in the United ; States. Some of the religious leaders, while not certain that a total moratorium ; should be placed on altering germline cells, signed the statement in order to ; stimulate public debate on the issue. Legislation has recently been introduced in ; Congress to set up a committee to monitor genetic engineering and its human ; applications, but author Jeremy Rifkin, the impetus behind the church leaders' ; resolution, argues that such tampering threatens the gene pool and should be ; banned altogether.
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  • 70
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    Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-10-14
    Beschreibung: Oncogenes capable of transforming NIH/3T3 cells are often present in human tumors and tumor cell lines. Such oncogenes were not detected in normal fibroblast lines derived from patients with several clinical syndromes associated with greatly increased cancer risk. Thus, germ-line transmission of these oncogenes does not appear to be the predisposing factor responsible for these high cancer risk syndromes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Needleman, S W -- Yuasa, Y -- Srivastava, S -- Aaronson, S A -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):173-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623066" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Transformation, Neoplastic/*pathology ; Cells, Cultured ; DNA, Neoplasm/*genetics ; Gardner Syndrome/genetics ; Humans ; Mice ; *Oncogenes ; Precancerous Conditions/*genetics ; Risk ; Skin/pathology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 71
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    Modulation of synapse formation by cyclic adenosine monophosphate (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-11-18
    Beschreibung: Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nirenberg, M -- Wilson, S -- Higashida, H -- Rotter, A -- Krueger, K -- Busis, N -- Ray, R -- Kenimer, J G -- Adler, M -- New York, N.Y. -- Science. 1983 Nov 18;222(4625):794-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6314503" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Antibodies, Monoclonal ; Calcium/physiology ; Cell Adhesion ; Cells, Cultured ; Cyclic AMP/*physiology ; Gene Expression Regulation ; Humans ; Membrane Potentials ; Nerve Tissue Proteins/physiology ; Neuromuscular Junction/*physiology ; Neuronal Plasticity ; Receptors, Cell Surface/physiology ; Retina/*physiology ; Synapses/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 72
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    Scientists settle cell line dispute (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-04-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, M -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):393-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836281" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibodies, Monoclonal/immunology ; California ; Cell Line ; Female ; Humans ; *Hybridomas ; Internationality ; Japan ; Jurisprudence ; Neoplasms/therapy ; potential use in cancer therapy, has been signed between Ivor Royston, an ; oncologist at the University of California at San Diego, and Hideaki Hagiwara, a ; visiting Japanese researcher who took part of the cell line back to Japan without ; permission and later injected some of the cells into himself, his parents, and ; other volunteers. The question of ownership was complicated by the fact that ; cells from Hagiwara's mother, a cancer patient, had been used to produce the ; hybridoma.
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 73
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    Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-02-18
    Beschreibung: alpha-Difluoromethyl ornithine and mouse type 1 interferon, when administered simultaneously, were highly toxic to B16 melanoma cells in culture. Oral administration of alpha-difluoromethyl ornithine suppressed B16 melanoma development in mice 85 percent whereas interferon given subcutaneously inhibited tumor growth only 24 percent. Total or near total suppression of tumor growth was observed in mice receiving both treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sunkara, P S -- Prakash, N J -- Mayer, G D -- Sjoerdsma, A -- New York, N.Y. -- Science. 1983 Feb 18;219(4586):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6186025" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Eflornithine ; Interferons/*administration & dosage ; Melanoma/therapy ; Mice ; Neoplasms, Experimental/*therapy ; Ornithine/administration & dosage/*analogs & derivatives ; Ornithine Decarboxylase Inhibitors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 74
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    Immunocytochemically identified vasopressin neurons in culture show slow, calcium-dependent electrical responses (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-09-09
    Beschreibung: From morphological characterization and intracellular recordings, monolayer cultures derived from fetal mouse hypothalami were found to include functionally differentiated peptide neurons, a number of which appear to contain vasopressin. These cells exhibited particular patterns of slow, calcium-dependent membrane depolarizations, resembling in their periodicity and duration the phasic activity of vasopressin neurons recorded extracellularly in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theodosis, D T -- Legendre, P -- Vincent, J D -- Cooke, I -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1052-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6348947" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Animals ; Calcium/*pharmacology ; Cells, Cultured ; *Electrophysiology ; Histocytochemistry ; Hypothalamus/analysis/*cytology ; Immunologic Techniques ; Mice ; Neurons/analysis ; Vasopressins/*analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 75
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    alpha-Difluoromethylornithine-induced polyamine depletion of 9L tumor cells modifies drug-induced DNA cross-link formation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-12-09
    Beschreibung: Depletion of intracellular levels of polyamines, which are believed to have a role in the intranuclear stabilization of DNA, alters the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II in 9L rat brain tumor cells. Alkaline elution techniques were used to show that polyamine depletion alters the number of DNA cross-links formed by these cytotoxic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tofilon, P J -- Deen, D F -- Marton, L J -- CA-09215/CA/NCI NIH HHS/ -- CA-13525/CA/NCI NIH HHS/ -- CA-31867/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 9;222(4628):1132-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6417790" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carmustine/*pharmacology ; Cells, Cultured ; Cisplatin/*pharmacology ; Cross-Linking Reagents ; *DNA/radiation effects ; Eflornithine ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase Inhibitors ; Polyamines/antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 76
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    Measurement of suppressor transfer RNA activity (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1983-08-26
    Beschreibung: Transfer RNA (tRNA) suppression of nonsense mutations in prokaryotic systems has been widely used to study the structure and function of different prokaryotic genes. Through genetic engineering techniques, it is now possible to introduce suppressor (Su+) tRNA molecules into mammalian cells. A quantitative assay of the suppressor tRNA activity in these mammalian cells is described; it is based on the amount of tRNA-mediated readthrough of a terminating codon in the influenza virus NS1 gene after the cells are infected with virus. Suppressor activity in L cells continuously expressing Su+ (tRNAtyr) was 3.5 percent and that in CV-1 cells infected with an SV40- Su+ (tRNAtyr) recombinant was 22.5 percent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J F -- Capecchi, M -- Laski, F A -- RajBhandary, U L -- Sharp, P A -- Palese, P -- AI-11823/AI/NIAID NIH HHS/ -- AI-18998/AI/NIAID NIH HHS/ -- GM17151/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308765" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cells, Cultured ; Eukaryotic Cells/physiology ; Genes, Viral ; Mice ; Orthomyxoviridae/genetics ; Peptide Chain Termination, Translational ; Protein Biosynthesis ; RNA, Transfer/*genetics ; Simian virus 40/genetics ; *Suppression, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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